"""trial"".""trial_id"""	"""trial"".""public_title"""	"""trial"".""recruitment_status"""	"""trial"".""study_type"""	"""trial"".""date_registration"""	"""trial"".""last_refreshed"""	"""trial"".""source_register"""	"""trial"".""id"""	"""trial"".""scientific_title"""	"""trial"".""scientific_title_native"""	"""trial"".""study_design"""	"""trial"".""study_phase"""	"""trial"".""allocation"""	"""trial"".""masking"""	"""trial"".""purpose"""	"""trial"".""date_enrolment"""	"""trial"".""primary_sponsor"""	"""trial"".""secondary_sponsors"""	"""trial"".""web_address"""	"""trial"".""target_size"""	"""trial"".""inclusion_criteria"""	"""trial"".""exclusion_criteria"""	"""trial"".""health_conditions"""	"""trial"".""interventions_summary"""	"""trial"".""contacts_summary"""	"""trial"".""results"""	"""trial"".""countries"""	"""trial"".""updated_on"""
RBR-88btzp	Evaluation of the Implantation of an Anticoagulation Clinic in the Assistance of Chagas and Non-Chagas Patients at the Hospital of Clinics of the Universidade Federal de Minas Gerais - UFMG	recruitment completed	Intervention	2011-05-10	<NULL>	<NULL>	1	A Randomized, Open-Label, Crossover Clinical Trial for Evaluation of Impact of the Implantation of an Anticoagulation Clinic in the Assistance of Chagas and Non-Chagas Disease Patients at the Hospital of Clinics of the Universidade Federal de Minas Gerais - UFMG	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Federal de Minas Gerais	Hospital das Clínicas da UFMG	https://ensaiosclinicos.gov.br/rg/RBR-88btzp	<NULL>	"Outpatients
Chagas and non-Chagas disease patients
Any indication for chronic treatment with warfarin
Anticoagulation for at least 30 days."	"Refusal to participate in the study
Use of phenprocoumon
Expectation of treatment lower than 1 year
Difficulties to attend medical visits
Participation in any other type of research involving anticoagulation during this study period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-36w269	"A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined with
Dasatinib to Docetaxel Combined with Placebo in Castration-Resistant Prostate Cancer"	recruitment completed	Intervention	2011-06-13	<NULL>	<NULL>	2	"A Randomized Double-Blind Phase 3 Trial Comparing Docetaxel Combined with
Dasatinib to Docetaxel Combined with Placebo in Castration-Resistant Prostate Cancer"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-01-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-36w269	<NULL>	"Subjects must have signed an informed consent document stating that they
understand the investigational nature of the proposed treatment.
History of histologically diagnosed prostate cancer.
Evidence of metastatic disease by any 1 of the following modalities: CT scan,
MRI, bone scan, or skeletal survey.
Evidence of progression, as defined by 1 of the following:
  Rising PSA values at least 1 week apart with the final value being &gt;= 2 ng/mL,or
  Progression of measurable nodal or visceral disease:
   Nodal lesions must be &gt;= 20 mm
   Visceral lesions must be measurable per RECIST criteria, or
   Two or more new lesions appearing on a bone scan compared with a prior
scan, or
   Local recurrence in the prostate or prostate bed.
Maintaining castrate status: Subjects who have not undergone surgical
orchiectomy should have received and continue on medical therapies [eg,
gonadotropin releasing hormone analogs (GnRH/LHRH analogs)] to maintain
castrate levels of serum testosterone &lt;= 50 ng/dL (1.7 nmol/L).
ECOG Performance Status 0 - 2.
At least 4 weeks since major surgery, radiotherapy, and an investigational agent.
At least 8 weeks since radioisotope therapy (eg, Strontium-89, Samarium-153 or
similar agents).
Recovery from local primary therapy of surgery or radiation.
 Required initial laboratory values:
 WBC &gt;= 3,000/mm3.
 ANC &gt;= 1,500/mm3.
 Platelet count &gt;= 100,000/mm3.
 Creatinine &lt;= 1.5 x upper limits of normal.
 Bilirubin &lt;= upper limit of normal (does not apply for subjects with Gilbert’s
Disease).
 SGOT (AST) &lt;= 2.5 x upper limits of normal.
 SGPT (ALT) &lt;= 2.5 x upper limits of normal.
Men only, at least 18 years old."	"Women.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Subjects with active brain metastases or leptomeningeal metastases are excluded
from this clinical trial.
Clinically significant cardiovascular disease, including myocardial infarction or
ventricular tachyarrhythmia within 6 months, prolonged QTc &gt; 450 msec, ejection
fraction (EF) &lt; 40% or major conduction abnormality, unless a cardiac pacemaker
is present.
Pleural or pericardial effusion of any CTC grade.
Peripheral neuropathy CTC Grade &gt;= 2.
Subjects with a “currently active” second malignancy other than non-melanoma
skin cancers are not to be enrolled into the study. Subjects are not considered to
have a “currently active” malignancy if they have completed therapy and are now
considered (by their physician) to be at less than 30% risk for relapse.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
HIV-positive subjects receiving combination anti-retroviral therapy.
History of allergic reactions attributed to compounds of similar chemical or
biologic composition to the investigational agents.
Subjects may not be receiving any other investigational agents for the treatment of
prostate cancer.
No prior cytotoxic chemotherapy in the metastatic setting, with the exception of
estramustine.
Subjects may continue on a daily multi-vitamin but all other herbal, alternative
and food supplements (eg, PC-Spes, Saw Palmetto, St John’s Wort) must be
discontinued before enrollment into the study.
Ketoconazole must be discontinued 4 weeks prior to starting study therapy.
Anti-androgens should be discontinued prior to starting study therapy. Subjects
with a history of response to an anti-androgen and subsequent progression while
on that anti-androgen should be assessed for anti-androgen withdrawal response
for 4 weeks. Observation for anti-androgen withdrawal response is not necessary
for subjects who have never responded to anti-androgens.
Bisphosphonates must not be initiated within 28 days prior to starting study
therapy.
QT prolonging agents strongly associated with torsade de pointes.
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-48pb9h	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	recruiting	Intervention	2011-06-13	<NULL>	<NULL>	3	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2010-07-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-48pb9h	<NULL>	"Subjects must sign an informed consent prior to any study-related procedures.
 Histologically or cytologically confirmed, stage IIIB (malignant pleural effusion), stage IV or recurrent Non Small Cell Lung Cancer;
 Measurable disease by Response Evaluation Criteria In Solid Tumors guidelines, with at least 1 target lesion outside any previous radiotherapy field;
 Eastern Cooperative Oncology Group performance status &lt; 1;
 Life expectancy of at least 3 months;
 Accessible for treatment and follow-up. Subjects enrolled in this trial must be treated at the participating center(s).
 Willing to give a whole blood sample for the study of proteins and genetic polymorphisms in genes related to the Vascular Endothelial Growth Factor signaling pathway.
 Men and women, ages &gt;18 years.
Women of childbearing potential must be using an adequate method of contraception to avoid pregnancy throughout the study [and for up to 6 weeks after the last dose of investigational product] in such a manner that the risk of pregnancy is minimized.
Women of childbearing potential include any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Postmenopause is defined as:
Amenorrhea &gt; 12 consecutive months without another cause or 
• For women with irregular menstrual periods and on hormone replacement therapy (HRT), a documented serum follicle stimulating hormone level &gt; 35 International Units/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 International Units/L or equivalent units of Human Chorionic Gonadotropin) within 72 hours prior to the start of investigational product."	"Women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period [and for up to 6 weeks after the last dose of investigational product]
Women who are pregnant or breastfeeding 
Women with a positive pregnancy test on enrollment or prior to investigational product administration
Sexually active fertile men not using effective birth control if their partners are Women of childbearing potential.
Evidence of predominantly squamous-cell histology (mixed cell type tumors only)
Known central nervous system metastasis
Less than 28 days elapsed following major surgery 
Excessive risk of bleeding such as history of clinically significant bleeding diathesis or coagulopathy including platelet function disorder (eg, known hemophilia or von Willebrand disease) or acquired bleeding disorder within 12 months (eg, acquired anti-factor VIII antibodies)
Gross hemoptysis (&gt;= 1/2 tablespoon of red blood)
Subjects receiving therapeutic anticoagulation
Thrombotic or embolic cerebrovascular accident including transient ischemic attacks within the past 12 months
Uncontrolled hypertension (defined as systolic blood pressure &gt;150 mmHg or diastolic &gt; 90 mmHg, measured repeatedly at &gt;=2 visits despite adequate treatment with &gt;= 2 antihypertensive drugs)
Clinically significant cardiovascular disease, including (but not limited to) the following:
 Myocardial infarction within the past 6 months
 Unstable angina
 New York Heart Association class II-IV congestive heart failure
 Serious cardiac arrhythmia (eg ventricular arrhythmia, high-grade atrioventricular block), not controlled by medication or requiring medication which might interfere with regularity of study treatment
 Left ventricular ejection fraction below institutional lower limit of normal as measured by 2-dimensional echocardiogram or cardiac MUGA scan.
 History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
 Serious non-healing wound, active peptic ulcer, non-healing bone fracture, or bleeding skin metastases
 Glomerulonephritis or other protein-wasting glomerulopathy
 Active clinically significant infection(&gt; Grade 2) requiring the use of antimicrobial agents, or that would otherwise, in the opinion of the investigator, interfere with the ability the subject to participate
 Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in-situ of the cervix
 Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
 Any serious uncontrolled medical disorder that, in the opinion of the investigator, would impair the ability of the subject to receive study therapy.
Hemoglobin &lt;9.0 g/dL, Absolute Neutrophil Count &lt;1500 cells/mm3, Platelets &lt;100,000 cells/mm3
Serum creatinine &gt;1.5 mg/dL
Calculated creatinine clearance &lt;50 mL/min (using Cockcroft and Gault formula)
Urine protein/creatinine ratio &gt; 1
Serum total bilirubin &gt;1.5 times the institutional upper limit of normal, unless due to Gilbert’s disease
Alanine transaminase or aspartate aminotransferase &gt;2.5 times the institutional upper limit of normal (&gt;5 times upper limit of normal for subjects with documented liver metastases)
Serum amylase and lipase &gt;1.5 times the upper limit of normal
Known hypersensitivity to any of the investigational products or excipients, including Cremophor EL®
Any prior antineoplastic systemic regimens for NSCLC. Subjects must not initiate any concurrent antineoplastic therapy while on study.
Prisoners or subjects who are involuntarily incarceratedSubjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness

Eligibility criteria for this study have been carefully considered to ensure the safety of the study subjects and to ensure that the results of the study can be used. It is imperative that subjects fully meet all eligibility criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-7spw98	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	recruiting	Intervention	2011-06-21	<NULL>	<NULL>	4	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7spw98	<NULL>	"All subjects must be informed of the investigational nature of this study and must
sign and give written informed consent in accordance with institutional and
federal guidelines.
Histologic or cytologic diagnosis of endometrial carcinoma.
Evidence that the cancer is locally advanced, recurrent or metastatic and not
curable by local measures (ie, surgery, radiation).
Karnofsky performance status (KPS) 70, 80, 90, or 100 (see Appendix 2).
Subjects must have measurable or non-measurable disease (see Section 6.4.3) that
has progressed since last treatment. A maximum of 140 subjects with
non-measurable disease will be randomized.
Notes:
 If the subject’s only disease is confined to a solitary lesion, its neoplastic
nature must be confirmed by histology or cytology.
 Disease in a previously irradiated field is acceptable as the only site of
measurable disease only if there has been clear progression since completion
of radiotherapy.
 All therapy directed at endometrial cancer must be discontinued 21 days prior to start of treatment, except for hormonal therapy which must be discontinued at
least 1 week prior to start of study treatment. Note: concurrent administration of hormone replacement therapy is allowed.
Subjects must have received one and only one prior chemotherapy (ie, cytotoxic)
regimen for locally advanced, recurrent or metastatic endometrial cancer. Subjects
with 1 additional prior chemotherapy regimen in the neoadjuvant or adjuvant
setting are allowed. Adjuvant/neoadjuvant therapy is defined as post or
preoperative therapy for Stage 1, 2, or 3 disease.
 Subjects may have received any number of prior non-cytotoxic regimens such as
monoclonal antibodies, cytokines, signal transduction inhibitors, or hormonal
therapy.
 Previous radiation therapy is allowed.
Women, ages 18 to older.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after the last dose of investigational product in such a manner that the risk of pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
  Amenorrhea ? 12 consecutive months without another cause or
  For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level &gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding.
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Carcinosarcoma (malignant mixed mullerian tumor)
Endometrial leiomyosarcoma and endometrial stromal sarcomas.
Subjects with no prior chemotherapy (ie, cytotoxic) for locally advanced,
recurrent or metastatic endometrial cancer or subjects that received 2 or more
prior chemotherapy (ie, cytotoxic) regimens for locally advanced, recurrent or
metastatic endometrial cancer.
Subjects with known brain metastases. Note: brain scans are not required.
Receipt of prior ixabepilone therapy.
Concurrent active infection requiring antibiotics or other therapy.
Concurrent unstable disease or other debilitating illness that could jeopardize
participation such as congestive heart failure, unstable angina, myocardial
infarction or other cardiac disease within last 6 months.
For subjects whose prior therapy did not include an anthracycline (eg,
doxorubicin) and therefore may be randomized to doxorubicin, LVEF of &lt; 50%
as measured by multi-gated radionuclide angiography (MUGA) or
echocardiography (ECHO).
History of prior malignancy within last 5 years except non-melanoma skin cancer,
carcinoma in situ of the cervix, or carcinoma in situ of the breast not treated with chemotherapy.
Known human immunodeficiency viral (HIV) infection.
Psychiatric disorders or other conditions rendering the subject incapable of
complying with the requirements of the protocol.
Absolute neutrophil count (ANC) &lt; 1500/mm3.
Platelets &lt; 100,000/ mm3.
Hemoglobin &lt; 9 g/dL.
Total bilirubin &gt; 1.5 times the institutional upper limit of normal (ULN), except for subjects with Gilbert’s disease.
AST or ALT &gt; 2.5 times the institutional upper limit of normal (ULN).
Serum creatinine &gt; 1.5 x institutional upper limit of normal (ULN).
Grade ? 2 neuropathy (sensory or motor).
Known allergy to any of the study drugs or their excipients such as, prior severe
HSR to agents containing Cremophor® EL.
No concurrent therapy directed at endometrial cancer (chemotherapy, hormonal,
or investigational during the study).
Subjects must not continue or institute treatment with the following strong
inhibitors of CYP3A4 from 72 hours prior to the initiation of study therapy until
end of treatment with ixabepilone or paclitaxel: Ketoconazole, itraconazole,
clarithromycin, atazanavir, nefazodone, saquinavir, telithromycin, ritonavir,
amprenavir, indinavir, nelfinavir, delavirdine, or voriconazole (See IB1).
Other concurrent anti-tumor, chemotherapy, hormonal therapy, immunotherapy
regimens or radiation therapy, standard or investigational therapy (see
Section 5.5).
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-84sdd6	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	5	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-05-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-84sdd6	<NULL>	"Voluntary signed and dated written informed consent form in accordance with
regulatory and institutional guidelines obtained before the performance of any
protocol-related procedures not part of normal patient care.
Histologic or cytologic confirmed diagnosis of HCC.
Advanced HCC
 disease not eligible for surgical and / or locoregional therapies
 progressive disease after surgical and / or locoregional therapies
Child-Pugh Class A 
ECOG performance status 0-1 
Life expectancy of at least 12 weeks
Accessible for treatment and follow-up
Locoregional therapy must be completed at least 3 weeks prior to the baseline
scan; previously treated lesions are not to be selected as target lesions.
At lease one measurable untreated lesion. All subjects must have at least one
previously un-treated, uni-dimensionally measurable lesion by CT or MRI scan &gt;=
20mm. Target lesions that are previously un-treated and are uni-dimensionally
measurable by spiral CT scan to be &gt;= 10mm will be permitted.
 The lesion can be accurately measured uni-dimensionally according to RECIST criteria
 The lesion has not been previously treated with surgery, radiotherapy, and /or
locoregional therapy (eg: radiofrequency ablation (RFA), percutaneous
ethanol or acetic acid injection (PEI / PAI), transcatheter arterial
chemoembolization (TACE) or cryoablation, etc.)
 Bone metastases are not considered measurable lesions.
Adequate hematologic function with absolute neutrophil counts &gt;= 1,500/mm3,
platelet count &gt;= 60 x 109/L, and hemoglobin &gt;= 8.5 g/dL
Adequate hepatic function with serum total bilirubin &lt;= 3 mg/dL, serum albumin
&gt;= 2.8 g/dL and ALT and AST &lt;= 5 times the institutional upper limits of normal
Amylase and lipase &lt;= 1.5 times the institutional upper limit of normal
Adequate renal function with serum creatinine &lt;= 2.0 mg/dL
International normalized ratio (INR) &lt;= 2.3 or Prothrombin time (PT) &lt;= 6 seconds
above control
Left ventricular ejection fraction (LVEF) &gt;= 50% as measured by 2-D Echocardiogram
All laboratory test finding should be stable within the range listed in 3a) - 3f)
without continuous supportive treatment, such as blood transfusion, coagulation
factors and / or platelet infusion, red / white blood cell growth factor
administration, albumin infusion, ursodeoxycholic acid, or drug treatment for
lowering liver enzyme / bilirubin, etc
Men and women, ages 18 or older
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 12 weeks
after the last dose of investigational product in such a manner that the risk of
pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
   Amenorrhea &gt;= 12 consecutive months without another cause or
   For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level
&gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal
products, skin patches, or implanted or injectable products), or mechanical
products such as an intrauterine device or barrier methods (diaphragm, condoms,
spermicides) to prevent pregnancy, or are practicing abstinence or where their
partner is sterile (eg, vasectomy) should be considered to be of childbearing
potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Brain metastasis or evidence of leptomeningeal disease
Known fibrolamellar HCC or mixed cholangiocarcinoma and HCC
History of encephalopathy
Ascites
Evidence of portal hypertension with bleeding esophageal or gastric varices
within the past 2 months
Main portal vein* or vena cava thrombosis or occlusion.
* Main portal vein is defined as the part of the portal vein between the inferior vena cava and the first bifurcation into the left and right vein. It is usually located in the porta hepatis.
Previous or concurrent cancer that is distinct in primary site or histology from
HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial
bladder tumors (Ta, Tis &amp; T1). Any cancer curatively treated &gt; 5 years prior to
entry is permitted.
History of active cardiac disease:
  Uncontrolled hypertension which defined as systolic blood pressure greater
than 150 mmHg or diastolic pressure greater than 90 mmHg despite optimal
medical management
  Congestive heart failure NYHA (New York Heart Association) class 3 and 4
  Active coronary artery disease, unstable or newly diagnosed angina or myocardial infarction less than 12 months prior to study entry
  Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta
blockers or digoxin
Valvular heart disease &gt;= CTCAE Grade 2
QTc (Fridericia) &gt; 450 msec on two consecutive ECGs. (baseline ECG should be
repeated if QTc is found to be &gt; 450 msec)
Thrombotic or embolic events within the past 6 months, such as a cerebrovascular
accident (including transient ischemic attacks), pulmonary embolism
Any other hemorrhage/bleeding event &gt;= CTCAE Grade 3 within 4 weeks except
for esophageal or gastric varices
Active infection, less than 7 days after completing systemic antibiotic therapy
Active, untreated hepatitis B
Psychiatric illness/social situations that would limit compliance with study
requirements
History of non-healing wounds or ulcers, or bone fractures within 3 months of
fracture
Major surgical procedure, open biopsy, or significant traumatic injury less than 3
weeks or those who receive minor surgical procedures (eg core biopsy or fine
needle aspiration) within 1 week
History of organ allograft or on an allograft waiting list
Portal-caval shunts
Inability to swallow tablets or untreated malabsorption syndrome
Pre-existing thyroid abnormality with thyroid function that cannot be maintained
in the normal range with medication
History of human immunodeficiency virus (HIV) infection
Substance abuse, medical, psychological or social conditions that may interfere
with the patient’s participation in the study or evaluation of the study results.
Any medical condition that is unstable or which could jeopardize the safety of the
patient and his/her compliance in the study.
Positive pregnancy test
Baseline serum sodium &lt; 130 mmol/L
Baseline serum potassium &lt; 3.5 mmol/L (potassium supplementation may be
given to restore the serum potassium above this level prior to study entry)
Known or suspected history of allergy to brivanib or sorafenib or any agents
given in association with this trial
Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular
targeted agents for HCC
Concomitant treatment with rifampin (and its analogues), or St John’s wort
Prior use of systemic investigational agents for HCC
Radiotherapy within 4 weeks prior to start of study drug
Required anticoagulation therapy with an agent such as coumadin, warfarin or
heparin
Required chronic anti-platelet therapy (aspirin at dose &gt;= 300 mg/day, clopidogrel
at dose &gt;= 75 mg/day)
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-5hzmjx	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	6	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-5hzmjx	<NULL>	"Written informed consent from subject, or from parents or legal guardians for
minor subjects, according to local law and regulation.
    Cohort #1: Subjects must have Ph+ CML in CP which is defined by the
presence of all the following criteria:
  &lt; 15% blasts in peripheral blood and bone marrow
  &lt; 20% basophils in peripheral blood
  &lt; 30% blasts + promyelocytes in peripheral blood and bone marrow
  &gt;= 100 X 109 platelets/L unless thrombocytopenia secondary to recent
treatment
  No extramedullary involvement other than liver or spleen
  Ph+ or variant must be demonstrated by bone marrow cytogenetics
   Cohort #2: Subjects must have Ph+ ALL or Ph+ AP- or BP-CML:
 Ph+ ALL have to be in first or subsequent relapse [ &gt;= 25% blasts in bone
marrow] or fail to achieve remission after imatinib
 AP-CML must meet at least one of the following criteria:
 &gt;= 15% but &lt; 30% blasts in peripheral blood or bone marrow
 &gt;= 30% blasts + promyelocytes in peripheral blood and in bone marrow
(but percent alone has to be &lt; 30%)
 &gt;= 20% basophils in peripheral blood or bone marrow
 &lt; 10 X 109/L platelets unrelated to therapy
  BP-CML has to meet all the following criteria:
 &gt;= 30% blasts in peripheral blood or bone marrow
 Presence of extramedullary blastic disease other than lymph nodes,
liver or spleen
 Subjects have to be proven resistant or intolerant to imatinib:
 For both cohorts, intolerance to imatinib is defined as the occurrence of any
toxicity grade &gt;= 3 considered at least possibly related to imatinib and that led
to discontinuation of previous imatinib therapy.
 For Cohort #1, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve, or loss of, CHR after &gt;= 3 months of imatinib at a
daily dose of 260 mg/m2 or greater;
 Failure to achieve MCyR after &gt;=6 months or CCyR after &gt;= 12 months of imatinib therapy at a daily dose of 260 mg/m2 or greater;
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib at a daily
dose of 260 mg/m2 or greater.
 For Cohort #2, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve CHR while on imatinib after a &gt;= 4-week treatment
or a &gt;= 50% increase in peripheral blood blasts over a 2-week period
 Subjects who achieved a CHR subsequently no longer meet the criteria
consistently over a consecutive 2-week period while receiving imatinib
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib.
 Lansky or Karnofsky scale &gt; 50 
 Life expectancy &gt;= 12 weeks
 Subjects must have recovered to baseline or Grade 1 (NCI CTCAE, version 3.0)
from the toxicities (except alopecia) resulting from recent therapies, including
chemotherapy, hormonal therapy, immunotherapy, biological therapy or
investigational product and radiation therapy.
 Serum Na, K, NaHC03, Mg, P and Ca levels within institutional normal limits
and AST, ALT, bilirubin, BUN or urea, creatinine ? Grade 2 (NCI CTCAE,
Version 3.0).
 Men and women, age &gt;= 1 to &lt; 21 years.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after
the last dose of investigational product in such a manner that the risk of pregnancy
is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,
or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined
as:
• Amenorrhea &gt;= 12 consecutive months without another cause or
• For women with irregular menstrual periods and on hormone replacement
therapy [HRT], a documented serum follicle stimulating hormone [FSH] level
&gt; 35 mIU/mL)
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Subjects for whom potentially-curative therapy is available, including
hematopoietic stem-cell transplantation (HSCT) at the time when subject is
assessed for enrollment
Subjects with isolated central nervous system disease are excluded from study.
This criterion relates to subjects with CNS-3 disease (? 5 leukemic blasts per
cubic millimeter in a sample with &lt; 10 erythrocytes per cubic millimeter).
Subjects with CNS-1 (no detectable blast cells in a sample of cerebrospinal fluid)
and CNS-2 (&lt; 5 leukemic blast cells in a sample with &lt; 10 erythrocytes per cubic
millimeter) are eligible for study. Subjects with a combined relapse which also
involves the CNS are eligible, provided this is asymptomatic (no convulsions or
other neurological symptoms).
Isolated extramedullary disease, with &lt; 5% blasts in bone marrow
Any serious uncontrolled medical disorder that would impair the ability of the subject to receive protocol therapy, including:
 Ongoing uncontrolled infection
 Clinically-significant disorder of platelet function (e.g. von Willebrand’s
disease) or ongoing gastrointestinal bleeding
 Clinically-significant cardiovascular disease, congenital long QT syndrome,
history of ventricular arrhythmias or heart block, or prolonged QTc interval &gt;
450 ms (Fridericia correction) on baseline electrocardiogram
 Subjects diagnosed with the T315I mutation (mutation testing should be
performed according to the investigator’s standard practice and is not
mandatory at sites without BCR-ABL testing available).
 Subjects who have experienced hypersensitivity to dasatinib or to any of the excipients. Inactive ingredients in dasatinib tablets include: lactose
monohydrate, microcrystalline cellulose, croscarmellose sodium,hydroxypropyl cellulose, and magnesium stearate. The tablet coating consists of hypromellose, titanium dioxide, and polyethylene glycol.
 Subjects with hereditary problems of galactose intolerance or Lapp lactase
deficiency or glucose-galactose malabsorption.
 Expected non-compliance to protocol schedule or unable to have regular followup
due to psychological, social, familial or geographic reasons
Prior therapy with dasatinib.
Any investigational agent or any other anti-cancer agent within 14 days prior to
treatment start. Imatinib mesylate may be continued up to 7 days before treatment
start, or, in the presence of rising peripheral blast cells, imatinib may be continued up to 2 days before treatment start. If required for control of peripheral blast cells,hydroxyurea, corticosteroids, 6-mercaptopurine or 6-thioguanine may be given up
to 2 days before treatment start.
Subjects requiring ongoing medications which may:
 Have a known risk of causing QTc prolongation ii) Irreversibly inhibit platelet function, or anticoagulants (Does not apply to low-dose heparin for prophylaxis or to heparin flushes for i.v. lines)
For Cohort #3: Prior chemotherapy, immunotherapy, or radiotherapy for CML
with the exception of hydroxyurea.
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-28gdtz	"A Randomized, Double-blind, Multi-center Phase III Study of Brivanib plus Best
Supportive Care (BSC) versus Placebo plus BSC in Subjects with Advanced
Hepatocellular Carcinoma (HCC) who have Failed or are Intolerant to Sorafenib"	recruitment completed	Intervention	2011-06-27	<NULL>	<NULL>	7	"A Randomized, Double-blind, Multi-center Phase III Study of Brivanib plus Best
Supportive Care (BSC) versus Placebo plus BSC in Subjects with Advanced
Hepatocellular Carcinoma (HCC) who have Failed or are Intolerant to Sorafenib"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-02-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-28gdtz	<NULL>	"Voluntary signed and dated written informed consent form in accordance with
regulatory and institutional guidelines obtained before the performance of any
protocol-related procedures not part of normal patient care.
Histologic or cytologic confirmed diagnosis of hepatocellular carcinoma.
Advanced disease defined as:
  Disease not eligible for surgical or loco-regional therapy or
 Disease progressive after surgical or loco-regional therapy
Patient has failed &gt;= 14 days of sorafenib treatment:
 Documented radiographic progression                       Documented symptomatic progression 
 Documented intolerance to sorafenib Cirrhotic status of Child-Pugh Class A or B with a score of 7).
Eastern Cooperative Oncology Group performance status 0, 1, 2 
Subjects who have a life expectancy of at least 8 weeks.
Accessible for treatment and follow-up.
Locoregional therapy must be completed at least 3 weeks prior to the baseline
scan; previously treated lesions are not selected as index lesions.
At lease one measurable untreated lesion. All subjects must have at least one
previously un-irradiated, bi-dimensionally measurable lesion by computerized tomography or magnetic resonance imaging scan &gt;= 20mm. Index lesions that are previously un-irradiated and are bi-dimensionally measurable by spiral CT scan to be &gt;= 10mm will be permitted.
 The lesion can be accurately measured bidimensionally according to WHO
criteria.
 The lesion has not been previously treated with surgery, radiation therapy,
radiofrequency ablation, percutaneous ethanol or acetic acid injection, or
cryoablation.
 Bone metastases are not considered measurable lesions.
Adequate hematologic function with absolute neutrophil counts &gt;= 1,500/mm3,
platelet count &gt;= 60 x 109/L, and hemoglobin &gt;= 8.5 g/dl.
Adequate hepatic function with serum total bilirubin &lt;= 3 mg/dl, serum albumin
&gt;= 2.8 g/dL and alanine aminotransferase and aspartate aminotransferase &lt;= 5 times the institutional upper limits of normal.
Amylase and lipase &lt; 1.5 times the institutional upper limit of normal.
Adequate renal function with serum creatinine &lt;= 2.0 mg/dl.
International normalized ratio (INR) &lt;= 2.3 or Prothrombin Time (PT) &lt;= 6
seconds above control.
Left ventricular ejection fraction (LVEF) &gt;= 50% as measured by 2-D
Echocardiogram.
Male or female subjects &gt;= 18 years of age.
Women of childbearing potential (WOCBP) must be using an adequate method
of contraception to avoid pregnancy throughout the study and up to 12 weeks
after the last dose of investigational product in such a manner that the risk of
pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
 Amenorrhea &gt;= 12 consecutive months without another cause or
 For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level
&gt;= 35 mIU/mL.
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine  pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding.
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Brain metastasis or evidence of leptomeningeal disease.
Known fibrolamellar HCC or mixed cholangiocarcinoma and HCC.
Any encephalopathy.
Any ascites.
Bleeding esophageal or gastric varices within 2 months prior to inclusion.
Previous or concurrent cancer that is distinct in primary site or histology from
HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial
bladder tumors (Ta, Tis &amp; T1). Any cancer curatively treated &gt; 5 years prior to
entry is permitted.
History of active cardiac disease:
 Uncontrolled hypertension which is defined as systolic blood pressure greater
than 150 mmHg or diastolic pressure greater than 90 mmHg despite optimal
medical management. Subjects with a history of persistent hypertension who
are receiving treatment with calcium channel blockers that are CYP3A4
substrates should be changed to an alternative antihypertensive medication.
 Congestive heart failure NYHA (New York Heart Association) class III and
IV 
 Active coronary artery disease, unstable or newly diagnosed angina or
myocardial infarction less than 12 months prior to study entry.
 Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta
blockers or digoxin.
 Valvular heart disease &gt;= Common Terminology Criteria for Adverse Events Grade 2.
QTc (Fridericia) &gt; 450 msec on two consecutive electrocardiograms. (baseline electrocardiogram should be
repeated if QTc is found to be &gt; 450 msec).
Thrombotic or embolic events within the past 6 months, such as a
cerebrovascular accident (including transient ischemic attacks), pulmonary
embolism.
Any other hemorrhage/bleeding event &gt; CTC AE Grade 3 within 4 weeks except
for esophageal or gastric varices 
Active infection, less than 7 days after completing systemic antibiotic therapy.
Psychiatric illness/social situations that would limit compliance with study
requirements.
History of non-healing wounds or ulcers, or bone fractures within 3 months of fracture.
Major surgical procedure, open biopsy, or significant traumatic injury less than 3
weeks or those who receive minor surgical procedures (eg core biopsy or fine
needle aspiration) within 1 week.
History of organ allograft or on an allograft waiting list.
Vena cava thrombosis or occlusion.
Portal-caval shunts.
Inability to swallow tablets or untreated malabsorption syndrome.
Pre-existing thyroid abnormality with thyroid function that cannot be maintained
in the normal range with medication.
History of human immunodeficiency virus (HIV) infection.
Substance abuse, medical, psychological or social conditions that may interfere
with the patient’s participation in the study or evaluation of the study results.
Any medical condition that is unstable or which could jeopardize the safety of
the patient and his/her compliance in the study.
Active, untreated hepatitis B.
Positive pregnancy test.
Hyponatremia with sodium &lt; 130 mmol/L.
Baseline serum potassium &lt; 3.5 mmol/L (potassium supplementation may be
given to restore the serum potassium above this level prior to study entry).
Known or suspected history of allergy to brivanib or any agents given in
association with this trial.
Prior use of any systemic anti-cancer chemotherapy or targeted agents for HCC
except for sorafenib (prior loco-regional treatment including TACE is allowed).
Prior immunotherapy for HCC.
Concomitant treatment with rifampin (and its analogues), and St John’s Wort.
Prior use of systemic investigational agents for HCC (except for sorafenib).
Radiotherapy within 4 weeks prior to start of study drug.
Required anticoagulation therapy with an agent such as warfarin or heparin.
Required chronic anti-platelet therapy (aspirin at dose &gt;= 300 mg/day, clopidogrel
at dose &gt;= 75 mg/day).
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-3d9kqb	Effect of peanut in appetite and diabetes risk	data analysis completed	Intervention	2011-06-29	<NULL>	<NULL>	8	Acute and second meal effects of peanuts on glycemic response and appetite in obese women a randomized crossover trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Federal de Viçosa	Peanut Collaborative Research Support Program	https://ensaiosclinicos.gov.br/rg/RBR-3d9kqb	<NULL>	Age 18 - 60 years, body mass index  between 30 - 35 kg/m2, not taking medications known to affect glycemia, fat metabolism, or appetite; regular breakfast consumer (?100 kilocalories ingested within 2 hours of waking on ?4d/wk); no body weight fluctuation (&lt;5kg in the past 3 months); willingness to eat all test foods; no self-reported allergy to the foods provided in the study; no self-reported sleep disorders; at least one of the following conditions: waist circumference ? 88 cm; reported family history of type 2 diabetes in first degree relatives; capillary glycemia between 5.5 – 7.0 mmol/L; and/or a 2-hour blood glucose of 7.8 – 11.1 mmol/L (impaired glucose tolerance).	Type 2 diabetes, dyslipidemia or high blood pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-4y59tq	Effect of the Informative Paper on patients and families in a Oncogenetic Ambulatory :evaluation of information and perception of coercion.	not yet recruiting	Intervention	2011-06-30	<NULL>	<NULL>	9	Randomized, double-blind study on the effect of the Informative Paper on patients and families in the Oncogenetic Ambulatory of universitary hospital: evaluation of information and perception of coercion.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4y59tq	<NULL>	Will be included all adult patients who receive a positive diagnosis at the Ambulatory of Oncogenetics/Medical Genetics Service of the hospital for six months and agree to participate in the research, documented by the Consent Term. Also included are all adult family members who seek care at the same ambulatory for a fixed period and accept to participate in the research, documenting the acceptance by Consent Term.	Will be excluded under 18 years old,those who do not accept and  those familiaries who attend the institution after the deadline.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-4hb6f6	Evaluation of electroacupuncture on the treatment of neck and sholder pain	data analysis completed	Intervention	2011-07-02	<NULL>	<NULL>	10	Evaluation of Electroacupuncture on the myofascial pain treatment of the upper trapezius muscle	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	<NULL>	Faculdade de Odontologia de Piracicaba/UNICAMP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4hb6f6	<NULL>	Female, age range from 18 to 40 years, at least one MTrPs in the upper trapezius muscle, local or referred persistent pain for at least six months, regular menstrual cycles controlled by the use of oral contraceptive, and right-handed.	Accentuated postural abnormalities, verified by the physiotherapist (MFMA), fibromyalgia syndrome, cervical radiculopathy, systemic disease or therapeutic interventions for physical myofascial pain within the past month before the study, pregnancy, chronic pacemaker or electronic implants, the last ones informed by the subject. The continuous use of medications to treat headache and muscular pain was also an exclusion criterion. Moreover, if evident cognitive impairment or communication difficulties were observed by the examiner (MFMA) at the first meeting, the subject was not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-5rt76n	Use of adhesive strip compared to physiotherapy in treating shoulder pain	recruiting	Intervention	2011-07-03	<NULL>	<NULL>	11	The Effects of Scapular Taping compared to physical therapy on Electromyographic Muscle Activity in subjects with subacromial impingement symptoms.	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-05-01	Universidade de Pernambuco	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5rt76n	<NULL>	"Inclusion criteria is described as: pain before 150° of active shoulder elevation in any plane, positive Jobe test indicating the possible supraspinatus involvement, positive
Hawkins–Kennedy and Neer test, subjective complaint of difficulty performing activities of daily living. 
All volunteers must be doing sports (handball, volleyball, swimming and judo / jujitsu) for at least two years, with six hours of weekly training."	Subjects will be excluded if they show signs or symptoms of any of the following: neural, cervical or thoracic pathological conditions; or previous surgery of upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6864tj	Treatment for pain reduction and the size of heel spur	recruitment completed	Intervention	2011-07-04	<NULL>	<NULL>	12	Evaluation of effects of iontophoresis and phonophoresis whit acetic acid in the treatment of plantar fasciitis calcifying	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	<NULL>	PUC Minas	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6864tj	<NULL>	Medical diagnosis of plantar fasciitis associated with the presence of limestone deposits in the plantar fascia and / or Achilles tendon, which was confirmed by radiological examination.	Exclusion criteria consisted of allergy to acetic acid; history of cancer, trauma, and recent surgery on his ankle, as well as open lesions and alteration of pain sensitivity in the same region, pregnant or lactating, using any kind of treatment for plantar fasciitis calcifying , Presence of rheumatoid arthritis and osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-3nm5bv	Effects of physical exercises in lung cancer individuals	recruiting	Intervention	2011-07-06	<NULL>	<NULL>	13	Impact of pulmonary rehabilitation in the incidence of postoperative respiratory complications in pulmonary resection for lung cancer	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2010-01-01	HOSPITAL DE MESSEJANA DR. CARLOS ALBERTO STUDART GOMES - SESA/CE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3nm5bv	<NULL>	"Staging of lung cancer among IA, IB, IIA, IIB and IIIA.
Medical Research Council (MRC)dyspnea scale at moderate to severe.
Candidate for pulmonary resection through thoracotomy.
Males and females aged greater than or equal to 38 years and less than or equal to 80 years."	"Severe cardiovascular or other diseases that contraindicate exercise;
Diseases with orthopedic impairments that preclude the exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2qdv84	Muscle Pain on the face,stress hormone and heart beat in patients with joint dysfunction of the mouth treated with laser	terminated	Intervention	2011-07-09	<NULL>	<NULL>	14	Evaluation myofascial chronic pain in pacients with Temporomandibular disorders and its relationship with serum cortisol and heart rate variability after  intervention physiotherapic by low level laser therapy	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	<NULL>	Faculdade São Lucas	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2qdv84	<NULL>	Female gender, non-smokers, normotensive, age group between 18 and 40 years, with diagnosis of temporomandibular disorder, presenting orofacial chronic pain (Gratt, Anbar 2005), which suggest that chronic pain is the pain that persists for more than four months, body mass index (BMI) normal and overweight (normality value of 18.5 to 27.5 Kg/m2) sent to physiotherapeutic treatment.	Volunteers with medical and/or dental emergencies, metabolic diseases (such as diabetes or hyperthyroidism), neurological disorders (e.g. , disquinesia and/or neuralgia of the trigeminus nerve etc. ), vascular disease (for example, hypertension), cancer, past history of psychiatric disorders, drug abuse, pregnant or breastfeeding women, history of recent accidents with powered vehicle, volunteers currently treated with medications for neurological disorders or psychological and making use of analgesics or nsaids, were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-7dq5xx	Study of the effect of negative expiratory pressure method generated in the mouth in bus drivers professionals subjects with suspect of obstructive sleep apnea.	recruiting	Observational	2011-07-11	<NULL>	<NULL>	15	Cross-sectional study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Nove de Julho - UNINOVE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7dq5xx	<NULL>	Male interstate professional bus drivers who agree to sign the Informed Consent Term.	"Subjects with ischemic and dilated heart disease;
Subjects with episodes of acute decompensation in the two months prior to the study protocol;
Subjects with primary heart valve disease;
or acute or chronic cardiopulmonary or neuromuscular diseases;
Subjects who have been submitted to recent surgical procedures in the region of the chest wall; or those with a history of stroke, drug users and those who abuse alcohol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-9k9hhv	Study of sleep, respiratory control during sleep and quality of life in morbidly obese subjects undergoing bariatric surgery.	recruiting	Intervention	2011-07-11	<NULL>	<NULL>	16	Sleep study, respiratory mechanics, chemosensitive response and quality of life in morbidly obese patients undergoing bariatric surgery: A prospective, randomized, controlled	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Nove de Julho - UNINOVE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9k9hhv	<NULL>	"Grade III morbid obesity (BMI between 40 and 55 kg/m²) or between 35 and 39 kg/m² with comorbidities;
Both gender patients aged 18 to 65 years;
Documented history of conventional weight loss attempts having proven unsuccessful over time;
Agreement to participate in the study through a signed term of informed consent."	"Any medical condition rendering surgery too risk;                                 
Clinically significant or unstable mental health concerns;
Pregnancy, lactation or planned pregnancy within two years of potential surgical treatment;
Smokers (at least 8 weeks prior to surgery), abusive alcohol use and/or drugs use."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-3ypm3f	Effects of mild versus moderate training in patients with heart failure.	not yet recruiting	Intervention	2011-07-18	<NULL>	<NULL>	17	Comparison of the effects of mild versus moderate aerobic training on the inflammatory markers, on oxidative stress and quality of life, in patients with chronic heart failure – a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG	Ambulatório de Insuficiência Cardíaca - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-3ypm3f	<NULL>	"Patients with diagnosis of heart failure for at least six months, clinically stable for at least two months before this study. 
Left ventricular ejection fraction &lt; 45%.
Aging between 25 and 59 years old.
Body mass index (BMI) &lt; 30 kg/m2.
Stage C of the guidelines from the American College of Cardiology and American Heart Association (2005).
Classes I to III from the New York Heart Association (NYHA).
Sedentary, as defined by American College of Sports Medicine (2007)."	"User of cardiac pacemaker.
Inflammatory diseases in acute phase;
Renal insufficiency.
Orthopedic or neurological impairments which limit the exercise performance.
History of respiratory disease, unstable angina, uncontrolled arrhythmias or peripheral obstructive arterial disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6pngwz	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients	other	Intervention	2011-07-20	<NULL>	<NULL>	18	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients not on dialysis	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	<NULL>	UNIVERSIDADE FEDERAL DE SAO PAULO	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6pngwz	<NULL>	All patients were older than 18 years and were followed by a nephrologist for at least 03 months.	Exclusion criteria were the presence of chronic inflammatory diseases, active malignancy, human immunodeficiency virus (HIV), viral hepatitis and chronic steroids intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5ypjzb	Bilateral arms function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	recruiting	Intervention	2011-07-31	<NULL>	<NULL>	19	Bilateral upper limbs function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	Nayara Correa Farias	https://ensaiosclinicos.gov.br/rg/RBR-5ypjzb	<NULL>	"Chronic Hemiparesis (at least six months after stroke);  Age over 21 years;
  Severe impairment in upper limb (Fugl-Meyer in the less 30/66);  Understanding simple order"	Patients with other associated neurological diagnosis;  Subjects with orthopedic injuries in the upper bounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-75ddtf	Rehabilitation in patients with carpal tunnel syndrome	recruiting	Intervention	2011-08-09	<NULL>	<NULL>	20	Conservative treatment in patients with carpal tunnel syndrome: randomized and controlled trial study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade de São Paulo	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75ddtf	<NULL>	Patients with clinical and electromyographic diagnosis of non surgical CTS.	Patients with no nerve damage associated with multiple complex lesions, bone or joint injury, the presence of central nervous system injury, or other chronic metabolic and degenerative rheumatic diseases, leprosy and diseases affecting the peripheral nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6c3bvm	Physical therapy protocol on normal birth puerperium	not yet recruiting	Intervention	2011-09-01	<NULL>	<NULL>	21	Physical therapy protocol on normal birth puerperium	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6c3bvm	<NULL>	Being resident in the city of Ribeirao Preto,  housewife for at least six months, being between 20 and 35 years old, weight between 60 and 70 pounds in the puerperium, height between 146 and 160 centimeters, having had an adequate weight gain during pregnancy (7 to 12 pounds), primigravida, vaginal delivery without episiotomy with laceration until 1 degree, having at least 6 hours after delivery and a maximum of 24 hours on the first visit, present abdominal diastasis larger than 2 centimeters (in caliper) and want to participate in the research	Perineal laceration greater than or equal to grade 2, forceps delivery, episiotomy, cesarean birth, abdominal diastasis under two centimeters or any pathology that would contraindicate a physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2c236v	Lower third molar removal with 2% articaine.	not yet recruiting	Intervention	2011-09-01	<NULL>	<NULL>	22	"Evaluation of the anesthetic efficacy and
hemodynamic effects in the use of 2% and
4% articaine associated with 1:200,000
epinephrine in lower third molar removals."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2c236v	<NULL>	"Precise indication of removal of the two
lower third molars in similar positions in the same volunteer, as observed on panoramic radiograph;
All patients will provide written informed
consent during the pretreatment screening period before any study procedures are performed. The patients will be randomly selected regarding gender. The minimum age for inclusion in the study will be 18 years old and the maximum 45 years old."	"Presence of systemic diseases;
Presence of local inflammation and/or
infection;
Any history of allergic reaction to local
anesthetics, gastrointestinal bleeding or
ulceration;
Cardiovascular and kidney diseases;
Asthma and allergy to aspirin, piroxicam or
any other non-steroidal antiinflammatory
drug;
Regular use of any non-steroidal
antiinflammatory drug, pregnancy or breast feeding."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5gvsgp	Outpatient Treatment of Patients with abnormal scars.	data analysis completed	Intervention	2011-09-07	<NULL>	<NULL>	23	Outpatient Treatment of Keloids in patients treated in Juiz de Fora - MG. 2010.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Presidente Antônio Carlos - Faculdade de Medicina de Juiz de Fora	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5gvsgp	<NULL>	We included all patients seen in primary routing path followed in an initial consultation and in their returns during treatment. We interviewed 62 patients with an interest in treating keloids as outpatients, but only 43 agreed to participate and signed an informed consent.	The patients who refused treatment, who denied signing the consent form during the initial consultation were eliminated from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6pq736	Oral Care and Pneumonia in Institutionalized Elderly	data analysis completed	Intervention	2011-09-07	<NULL>	<NULL>	24	Efficacy of Oral Hygiene Practices on Aspiration Pneumonia Oral Pathogens in Elderly Nursing Home Residents	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal do Espírito Santo	Maria Cecilia Azevedo de Aguiar	https://ensaiosclinicos.gov.br/rg/RBR-6pq736	<NULL>	Being elderly (older than 60 years old) and to live at the long-term care facility selected for the research	Diagnosis of neoplastic or infectious disease during the study stages; Inability to breathe or feed by natural means (dependence on mechanical ventilators or feeding tubes); Need for antimicrobial therapy or hospitalization in the three months prior to intervention; Dependence on immunosuppressive drugs; Diagnosis of Sjögren&apos;s syndrome; Persons who had received radiotherapy with irradiation field covering the head and neck.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-48x3xv	Comparative study of the influence of blood flow, oxygenation and hemodynamics generated during the use of extracorporeal circulation machine	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	25	Comparison of the influence of two blood flow patterns generated by cardiopulmonary bypass pump in oxy-hemodynamic markers  during cardiopulmonary bypass	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Instituto Nacional de Cardiologia	Maria aparecida Nogueira de Lima Marcondes Salgado	https://ensaiosclinicos.gov.br/rg/RBR-48x3xv	<NULL>	Patient admitted to the National Institute of Cardiology,  which have coronary heart disease and were referred for surgery for isolated primary CABG, patients with ejection fraction greater than or equal to 45%, both sexes; aged between 18 and 75 years, during cardiopulmonary bypass use of vacuum-assisted venous drainage and use of normothermia during cardiopulmonary bypass	Patient admitted to the National Institute of Cardiology, which appear as disease and / or diagnosis associated with surgery, recent myocardial infarction (less than 3 months), recent stroke (less than 3 months, unstable angina, urgent or emergency surgery, diabetes mellitus decompensated - disease of diabetic ketoacidosis, renal failure - creatinine clearance &lt;30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-32ym5t	Electrical stimulation in healthy individuals	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	26	Interferencial current produce peripheral vasodilation in healthy individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade de Brasília	Hospital das Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-32ym5t	<NULL>	Individuals of both sexes, with age group from 19 to 44 years, non-smokers, non-obese and free of any signs or symptoms of disease, as revealed by the medical history, physical examination and electrocardiogram at rest and during exercise	Pregnancy, breastfeeding, alcohol or drug abuse and any medication with potential effects on the circulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5j32mm	The exercises for the pelvic muscles improves female orgasm?	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	27	Effect of kinesiotherapy in the contractility of pelvic floor in women with orgasmic dysfunction: electromyographic evaluation.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Estadual de Campinas - UNICAMP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5j32mm	<NULL>	"Women aged between 18 and 40 years old;
With sexually active, regular partner at least one year;
Use oral contraceptives
No symptoms of urinary / fecal incontinence;
Domain orgasm FSFI with a score &lt;3.0 (which features the orgasmic dysfunction, according to the instrument);
Coefficient of orgasmic capacity - COC &lt;1 (low orgasmic capacity, according to the instrument);
Force of contraction of the pelvic floor compromised."	"Peripheral or central neurological disorders;
History of pelvic floor muscle training;
History of any treatment for sexual dysfunction;
Presence of symptoms of urinary / fecal incontinence;
Reporting of clinical diagnosis: vaginismus, type III and IV prolapse, diabetes, dislipedemias; menopause or menopause, hypertension, depression;
Reporting of primary anorgasmia (never had an orgasm);
Pregnant women;
More than three pregnancies and / or three births;
Have the orgasm domain scores &gt;3.0; high orgasmic capacity (CCO &gt; 1);
Without compromising the strength of contraction of the pelvic floor;
Patient has not achieved 75% of the proposed therapy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-8jgwpr	Effects of noninvasive ventilation after cardiovascular surgery: A Randomized Clinical Trial	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	28	Effects of noninvasive mechanical ventilation on the hemodynamic and ventilatory parameters in post-cardiac surgery patients who developed hypoxemia after tracheal extubation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Alessandra Preisig	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS)	https://ensaiosclinicos.gov.br/rg/RBR-8jgwpr	<NULL>	"Postoperative cardiovascular surgery (valve replacement, thoracoabdominal aortic surgery and/or coronary artery bypass graft (CABG);
Sternal incision and pulmonary artery catheter from surgical ward 
Both genders, aged between 18 and 80 years."	"Severe chronic obstructive pulmonary disease,
Previous neurological disease and inability to understand;
More than 24 hours on mechanical ventilation;
Surgical revision for bleeding after tracheal extubation;
Emergency surgery;
Swan-Ganz catheter nonfunctioning"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2qxmd9	Strengthening exercises for strength and ability to manipulate objects in people with rheumatoid arthritis in the hands.	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	29	Strengthening exercises for hand muscles to increase strength and improve functionality in individuals with rheumatoid arthritis hand deformities.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-07-01	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital de Clínicas da FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-2qxmd9	<NULL>	Women diagnosed with rheumatoid arthritis  and presenting deformity in at least one of the fingers of each hand participated voluntarily in the present study. Each hand should present at least one of the following deformities: swan neck, boutonniere finger and Z-shaped thumb. Deformities as bouchard&apos;s nodules and ulnar deviation should be obligatorily present in both hands.	Women presenting other rheumatoid arthritis -related diseases and/or who entered the exacerbation phase (symptoms of inflammation in the hand joints) during the experimental time were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2xxp48	Efeito de bebida rica em fibra na redução da glicemia de diabéticos	recruitment completed	Intervention	2011-09-26	<NULL>	<NULL>	30	Effect of juice diet enriched with soluble fiber in reducing blood glucose of patients with diabetes mellitus type 2	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-01	Universidade Federal de Goiás	Ana Clara Martins e Silva Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-2xxp48	<NULL>	Inclusion criteria are: to be with diabetes mellitus type 2, has a body mass index above 25 kg/m2 and waist circumference increased, being sedentary, belong to the age group between 30 and 59 years and sign the Informed Consent Informed Consent (IC).	The exclusion criteria are: patients who are taking insulin, with chronic complications of diabetes, gastrointestinal disorders and intolerance fibers, pregnant and lactating women, and those who do not complete the follow-up during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-26ydc3	Effect of a pharmacotherapeutic management protocol in patients hospitalized with cardiovascular diseases	recruiting	Intervention	2011-10-27	<NULL>	<NULL>	31	Improving Medication Adherence and Clinical Outcomes Following Hospitalization in Chronic Cardiovascular Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-07	Alfredo Dias de Oliveira Filho	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-26ydc3	<NULL>	"Aiming maximum inclusiveness we recruited all patients who had a discharge diagnosis
of CVD and who were on antihypertensive medication."	Patients were excluded if they reported already using any tool to improve their adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2dgbbz	Training and reaching in premature infants	recruiting	Intervention	2011-10-30	<NULL>	<NULL>	32	Evaluation of a training on the performance of reaching in late preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de São Carlos (UFSCar)	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2dgbbz	<NULL>	Infants born between 34 weeks and 36 weeks and 6 days of gestational age (late preterm infants), appropriate for gestational age, with first and fifth minute Apgar Scores greater than 7, with adequate motor performance according to the Alberta Infant Motor Scale (AIMS), without major pre- and perinatal complications, and at maternal care.	Infants who do not attend the evaluations/training in the scheduled period (until 5 days after the infant reaching acquisition) or do not perform reaching movements at the pre-training evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-9hhr2g	Exercises to strengthen the perineum after childbirth.	recruitment completed	Intervention	2011-11-06	<NULL>	<NULL>	33	Effects of a training program of pelvic floor muscles after childbirth.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-17	Programa de pós-graduação em Ciências da Saúde da Universidade Federal de Goiás	Waldemar Naves do Amaral	https://ensaiosclinicos.gov.br/rg/RBR-9hhr2g	<NULL>	Inclusion criteria were maternal age between 18 and 35 years, parous women (2-4 children) and late postpartum vaginal delivery of a single fetus at term (in current and previous births).	Postpartum women were excluded who required the use of forceps during vaginal delivery (current and past births), women who underwent vaginal delivery of babies over 4 kg and below 2.5 kg (current and past births) in women who have had surgery perineal region, women with urinary symptoms before, during or after pregnancy and who performed perineal exercises before or during pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-6qs4tb	Effects of treadmill training with partial body weight support and the one physical therapy method on gait of patients with stroke	data analysis completed	Intervention	2011-11-09	<NULL>	<NULL>	34	Analysis of the effectiveness of treadmill training with partial body weight support and the Proprioceptive Neuromuscular Facilitation method on the hemiparetic gait due to stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Ana Raquel Rodrigues Lindquist	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6qs4tb	<NULL>	The sample was composed of men and women, aged between 40 and 70 years, with chronic hemiparesis following unilateral and non-recurring stroke, with spasticity classified between levels 0 and 2 on the Modified Ashworth Scale of muscle spasticity for the lower limb affected; ambulatory capacity classified between levels 3 and 5 on the Functional Ambulatory Category; minimum sequel time of 6 months; absence of clinical signs of cardiac alterations (New York Heart Association, degree I); absence of other orthopedic or neurological impairment that caused gait alterations; ability to walk 10m without assistive devices; not using orthotics on the paretic lower limb; and capacity to obey simple verbal commands.	Exclusion criteria were individuals whose heart rate exceeded 75% of age-adjusted maximum heart rate and those who had fear of falling while walking on the treadmill.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3bms6f	Sitting posture and changes in respiratory function	data analysis completed	Observational	2011-11-13	<NULL>	<NULL>	35	Sitting position and respiratory function in two significantly different chair-table system	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-05	Universidade de São Paulo	Laboratório de Fisioterapia e Comportamento da FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-3bms6f	<NULL>	Female university students, aged between 18 and 25 years, regularly enrolled in a public University, healthy, Caucasian, right-handed, sedentary, with body mass index between 18.5 to 24.9 kg/m2	Diseases of the respiratory system or musculoskeletal system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-994xfs	Effects of specific therapies on the masticatory system and on sleep variables  in cerebral palsy patients.	recruiting	Intervention	2011-11-24	<NULL>	<NULL>	36	Randomized, five arm clinical trial to evaluate the effects of neuromuscular electrical stimulation, lasertherapy and ledtherapy on the masticatory system and the impact on sleep variables  in cerebral palsy patients.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	UNESP-Universidade EStadual Paulista Juluo de Mesquita Filho/ Faculdade de Odontologia de Sâo José dos Campos	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-994xfs	<NULL>	Subjects from both gender, between 7-15 years old with cerebral palsy; present cognitive system partly preserved; sign the consent term.	Have used botulim toxin before 6 month prior the study;have underwent ortodontic treatment prior the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-4bk94x	Effect of electrical stimulation on pain and masticatory muscle activity in women with temporomandibular joint dysfunction.	recruitment completed	Intervention	2011-12-06	<NULL>	<NULL>	37	Effect of high voltage electrical stimulation - negative pole - on pain and electromyographic activity of masticatory muscles in women with temporomandibular disorders.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-01	Delaine Rodrigues Bigaton	Delaine Rodrigues Bigaton	https://ensaiosclinicos.gov.br/rg/RBR-4bk94x	<NULL>	The study included women with TMD, diagnosed according to RDC / TMD axis I, with pain and / or fatigue in the muscles of mastication during functional activities for a minimum period of six months. The volunteers had body mass index (BMI) of up to 25 kg/m2.	The study excluded women with missing teeth, with dental prosthesis, with systemic diseases such as osteoarthritis, osteoarthritis and diabetes, history of trauma to the face and the temporomandibular joint, joint dislocation, facial paralysis and orthodontic treatment and medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-4mxksj	Study on the benefit of the use of protocols in the care of chest pain in emergency physicians of the Cardiology Institute of Santa Catarina	data analysis completed	Intervention	2011-12-14	<NULL>	<NULL>	38	Compliance assessment to the Recommendations of the Corporate Guidelines through a Protocol Approach to Acute Coronary Syndrome by residents in the Emergency Room of Cardiology Institute of Santa Catarina: a Cluster Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Instituto de Cardiologia de Santa Catarina	Instituto de Cardiologia de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4mxksj	<NULL>	All eight residents of Instituto de Cardiologia de Santa Catarina will be included in the study.	Residents who do not agree to sign the term of consent form (free and clear).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3p5s66	Physical therapy on quality of life in patients with Urinary Incontinence	recruiting	Intervention	2011-12-06	<NULL>	<NULL>	39	The influence of physiotherapy intervention on quality of life in patients with urinary incontinence	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-07-03	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3p5s66	<NULL>	Female subjects with a medical diagnosis of urinary incontinence will be included. They will be referred from the Urogynecology outpatient&apos;s clinic of the Hospital São Lucas from the Pontifícia Universidade Católica do Rio Grande do Sul. Previous to their inclusion on the study, all subjects will have signed the free informed consent form.	There will be excluded women that  during the study period perform any additional physical therapy, or initiate any kind of structured and planned physical activity in addition to those provided in the protocol, those with medical conditions that promote disability other than the urinary incontinence, such as severe lung disease, neurological diseases, malignancies, severe cardiac disease or those who have undergone surgery for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2xgjh3	Physical performance in older adults after exercise program	data analysis completed	Intervention	2011-12-05	<NULL>	<NULL>	40	A proposal for intervention through exercise for the elderly: implications for physical fitness and functional hability	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-06-08	Universidade de Fortaleza	Wilson Max Almeida Monteiro de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-2xgjh3	<NULL>	People who belong to the group of elderly Community Center Luiza Tavora, aged 60 years or over, physically independent, of both genders and voluntarily consent to participate	Failure to understand instructions, due to some cognitive problem, the dependence on a wheelchair, crutches or apparatus to walk or need help to remain standing; paralysis in one end of the arms or legs, uncontrolled high blood pressure (&gt; 160 / 100mmHg) before testing and reports of chest pain or dizziness, trouble bone / joint / muscle or some other condition that would preclude participating in previous motor tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-76mm75	Phytoestrogens for controlling climacteric symptoms	recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	41	The use of Phytoestrogens, low dose hormone therapy and placebo to treat psychological, somatic and urogenital  symptoms in climacteric women: randomized, controlled, double-blind, clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-01	UNICAMP	UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-76mm75	<NULL>	Inclusion criteria consisted of postmenopausal women between 40 and 60 years of age who had had their last menstrual period more than 12 months previously, had follicle-stimulating hormone (FSH) levels higher than 30mIU/mL and estradiol levels  lower than 20 pg/ml, who were having more than 8 hot flashes in 24 hours, had not been using any form of hormonal treatment during the previous six months and were not currently using any lipid-lowering drugs, antidiabetic drugs, soybean derived products or herbal supplements.	The exclusion criteria consisted of: previous hysterectomy, chronic gastrointestinal disorder, any contraindication to hormone therapy or patients participating in another clinical trial. Finally, women were excluded if they had a known allergy or hypersensitivity to soy or cow milk or were not willing to cease consumption of soy products for the 16 weeks of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-257zbc	Study of the effect of a new treatment with antibiotic in babies with brochiolitis.	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	42	Using azithromycin to reduce bronchiolitis length of hospital stay in infants.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2010-09-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-257zbc	<NULL>	Infants younger than 12 months, with diagnosis of acute bronchiolitis and hospitalization for at least 24 hours.	Chronic lung disease, cystic fibrosis, congenital heart diseases and previous use of macrolides.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-6ynv5y	Posture and mobility in adolescents federated in basketball.	data analysis completed	Observational	2012-01-04	<NULL>	<NULL>	43	Postural and mobility characterization of adolescent basketball athletes.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade de São Paulo	Fundação de Amparo para a pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ynv5y	<NULL>	The inclusion criteria was based on adolescents aging between 12 to 16, male adolescents. The athlete group was federated exclusively to basketball (at least 10 hours per week).	The exclusion criteria was based on orthopedic, respiratory, rheumatic and neuromuscular diseases. And the athletes shouldn’t be federated to another sport.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-6twwh2	Nursing consultation in the monitoring of adults with type 2 diabetes.	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	44	Effect of using the method of case management on glycemic control in people with type 2 diabetes.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-12	Universidade Federal do Paraná	Universidade Estadual do Norte do Paraná.	https://ensaiosclinicos.gov.br/rg/RBR-6twwh2	<NULL>	"Being patient with type 2 diabetes mellitus;
Both sexes;
Age between 18 and 60 years;
Accept the invitation to participate in the survey;
Being a resident of Bandeirantes city."	"People with type 2 diabetes who have psychiatric disorders, which affect the language;
People with type 1 diabetes;
Pregnant women;
Persons who plan to move to another neighborhood that has not attended for the UBS-ESF or PACS, or even moving to another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2wjrp4	Evaluation of four types of therapies for the treatment of urogenital atrophy in postmenopausal women	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	45	Randomized controlled clinical trial, with topical use of estrogen,testosterone, polyacryli cacid and placebo in the treatment of urogenital atrophy in postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM Unicamp	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-2wjrp4	<NULL>	"Physiological menopause with amenorrhea over three years

FSH&gt; 30 IU

Aged over 40 years and less than 75 years.

Women are not on medication for hormonal treatment of menopausal symptoms in the last 6 months

Women who have mammography and Pap smear in the last 12 months with appropriate result

Women with symptoms of urogenital atrophy."	"The patient&apos;s explicit refusal to participate

Patient with bilateral oophorectomy

Patients with a BMI less than 18.5 kg / m² or greater than 30 kg / m²

Women who present contraindication  to the use of topical estrogen, as follows: Absolute (recent myocardial infarction, severe hypertension, diabetes mellitus is difficult to control, history of thromboembolic disease, recent Liver failure, or severe, or activity, prior breast cancer , Cancer of the endometrium prior mammary dysplasia with atypical hyperplasia, genital bleeding of unknown origin) or relative (family history of breast cancer, endometrial hyperplasia prior Cholelithiasis)

Women who have ulcerative colitis, Crohn&apos;s disease or diarrhea due to intestinal disease

Women who have positive serology for HIV, Hepatitis B and C

Patients on medication for depression or other psychiatric disorders"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-97kdbr	Effect of walk back training on the treadmill in locomotion of elderly with osteoarthritis of knee	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	46	Effect of gait training back on the treadmill in locomotor function of older adults with osteoarthritis of knee	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-30	Universidade do Estado de Santa Catarina	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-97kdbr	<NULL>	Older adults diagnosed with osteoarthritis, male and female, older than 60 years, presence of pain and stiffness of the knee to at least six months for activities in the standing position, joint pain during passive motion, intermittent swelling, radiographic joint degeneration, and who possess a medical certificate allowing physical activity.	Will be excluded individuals who present systemic rheumatic disease, previous surgery of the lower limbs, making use of orthoses for walking, any other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2tthrr	Effect of the use of body image stimulation in the treatment of ankle sprains in athletes	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	47	Effectiveness of motor imagery in the treatment of ankle sprains in athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2tthrr	<NULL>	Athlete&apos;s soccer with acute ankle sprains, male and female, aged between 16 and 45 years and underwent a medical evaluation prior.	Sprains associated with lower limb bone fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-4t949d	Effect of elastic bandage on the jump and balance of athletes	recruitment completed	Intervention	2011-07-17	<NULL>	<NULL>	48	Analysis of the effectiveness of Kinesio Tape on the performance of jumping and dynamic balance in athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4t949d	<NULL>	Men and women, aged between 18 and 45 years, athletes of jump modalities that do not have previous neurological or vestibular disorders, musculoskeletal or any change that interferes with or contra-indicate the measurement procedures of this study	Athletes who are minors, they do not use methods that have jumps and vestibular disorders, neurological or musculoskeletal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-7gt9pb	Effects of electric stimulation cutaneous and vaginal in women with stress urinary lost	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	49	Comparison of the effects of intravaginal electrical stimulation and surface electrical stimulation in women with stress urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-7gt9pb	<NULL>	Women older than 50 years of age; Complaint of stress urinary incontinence; Never have undergone physical therapy for UI treatment.	Levels 3 or 4 pelvic prolapse; Urinary and vaginal infection; Cardiac pacemaker; Metallic implant in pelvis and femur;  Pelvic radiotherapy; Pregnancy; Surgery for urinary incontinence; Cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-5g7xqh	Effects of acupuncture on muscle strength of healthy subjects and stroke patients	data analysis completed	Intervention	2011-10-26	<NULL>	<NULL>	50	Immediate effects of manual acupuncture on the biceps brachii muscle function in healthy subjects and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-12	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-5g7xqh	<NULL>	"Control group: Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research.
Hemiplegic group: Clinical diagnosis of upper neuron lesion due to stroke for at least 6 months, confirmed by image exams, both ischemic of hemorragic; Partial motor impairment of the upper limb function (hemiparesis); Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research."	Incomplete realization of any electromyographic signal acquisition; Low quality of electromyographic signal (less than 2-out-of-3 visible contraction events).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2g27zn	Effect of the physical training in community-dwelling older women: randomized clinical assay	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	51	Effectiveness of the training with isolated load, training with load associated with the aerobic and isolated aerobic training on the functional and muscular performance, on the plasmáticas concentrations of inflammatory mediators and on the satisfaction with the life in community-dwelling older women	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Centro Universitário de Belo Horizonte - Uni-BH	Centro Universitário de Belo Horizonte - Uni-BH	https://ensaiosclinicos.gov.br/rg/RBR-2g27zn	<NULL>	Aging, community-dwelderly women, without distinction of race and/or social class, with equal age or above of 65 years old.	Previously submitted the orthopeadic surgeries of the inferiors members and/or with history of fracture it less has of one year; those that will not be capable to walking without aid; carrying of neurological illnesses; that to present some type of inflammatory illness in the acute phase that they can intervene with the tests; neoplasia in the five previous years; that to use drugs with ample action on the immunological system; that to present detectable cognitivas alterations by means of Mini-Examination of the Mental State; that to carry through physical activity of regular form for more than two times in the week;  to make use of some type of canal choke of calciun (Ca++), inhibitors of the Converting Converting Enzyme of Angiotensina II (ECA) and use of estatinas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-59f4yr	Effect of acupuncture on anxiety in infertility women	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	52	Effect of acupuncture on anxiety in women undergoing to in vitro fertilization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-59f4yr	<NULL>	Women newer than 45 years, without previous psychiatric disorders, without use of antidepressants and / or anxiolytics and without use of acupuncture before.	Women older than 45 years, previous psychiatric disorders, use of antidepressants and / or anxiolytics and use of acupuncture before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-95jnqp	Effect of carvedilol medication and vitamins E and C in patients with Chagas&apos; disease.	recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	53	Effect of carvedilol and antioxidant vitamins (E and C) in patients with chronic Chagas cardiopathy.	<NULL>	4, non-randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal do Rio de Janeiro	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95jnqp	<NULL>	We included only patients who had previously studied the oxidative stress in the year 2003 onwards, aged between 21 and 70 years active and regularly monitored in ambulatory Chagas Service of Cardiology HUCFF diagnosed with Chagas disease, and that maintained the same eating habits. We only included patients with Chagas disease without other chronic diseases, apart from an endemic area for over 20 years.	"Patients were excluded from the study if they had any of the following characteristics:
Patients who have not completed the initial protocol of admission;
Patients previously treated with carvedilol;
Patients who were treated specifically for Chagas&apos; disease;
Patients with clinical or laboratory findings suggestive of severe liver or kidney disease or thyroid dysfunction;
Patients with a history of chronic obstructive pulmonary disease (all
forms), chronic alcoholism or smoking;
Patients with anemia, obesity, hypertensive heart disease, diabetes mellitus or other systemic disease;
Patients with signs, symptoms or a history of ischemic heart disease
confirmed after investigation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3jg332	Quality of life in patients of high pressure	terminated	Intervention	2012-01-04	<NULL>	<NULL>	54	Quality of life in patients of hypertension arterial systemic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Centro Universitário de Rio Preto - UNIRP	JOAO SIMAO DE MELO NETO	https://ensaiosclinicos.gov.br/rg/RBR-3jg332	<NULL>	Having 18 years old or more, being provided with hypertension, making this drug treatment.	Have diseases that can greatly influence the quality of life of these patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-93ggrm	Effect of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	other	Intervention	2012-01-04	<NULL>	<NULL>	55	Randomized clinical trial, controled, duble blind, four arms, to evaluate the impact of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-30	UNINOVE -Universidade Nove de Julho- São Paulo - SP	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-93ggrm	<NULL>	Man and woman, at list with 20 years old, ody mass index lower than 30, with no co-morbidities, apnea/hipopnea index moderate to severe, opening of 40mm, mandibular protriusion 7mm, periodontal health.	Psychiatric deseases, use fo any drugs that interfer in sleep, severe temporomandibular dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-88vgp6	Effects of soy beans isoflavone in the vagina and the uterum in the post menopausal womens	recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	56	Effects of Glycine max (L.) Merr in the vaginal epitelium and the endometrium in post menopausal women	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-01-01	FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO	FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO	https://ensaiosclinicos.gov.br/rg/RBR-88vgp6	<NULL>	"Women with age 45-68 years old
Vaginal atrophy simptons
Menopause &gt;12 months
With out hot flushes
No contraindications for hormonal terapy"	"Hot flushes symptons
Breast neoplasy and endomtrium
With Hormonal teraphy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-2h3d6b	Effect of nebulized saline on mucociliary transport	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	57	Effect of Nebulisation on the Mucociliary Nasal Transport	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Faculdade de Medicina de Ribeirão Preto	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2h3d6b	<NULL>	Volunteers aged between 18 and 30 years old were selected amongst the Ribeirão Preto School of Medicine undergraduate and post-graduate students for study	Those with smoking habits, cystic fibrosis, sinusitis, rhinitis, ciliary dyskinesia, hypertrophy of lower turbinates, major septal deviation, upper and lower airways infections in the last four weeks prior to study, bronchiectasis, and individuals who underwent surgery in the upper airways were excluded from study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-9fwv27	Study of gait and balance of subjects suffering from diabetic foot complications.	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	58	Gait parameters, plantar pressures and body balance of diabetics with neuropathy and vasculopathy that use insoles	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-10	Faculdade de Ciência e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9fwv27	<NULL>	In the diabetic group, will need medical confirmation of diabetes mellitus, changes in the circulation and peripheral perfusion, detected respectively by the ankle/ brachial index and pulse oximetry, and diabetic neuropathy confirmed by insensitivity to the Semmes-Weinstein monofilament 10g and the scale for the diagnosis of diabetic distal polyneuropathy. For the control group, it is mandatory sensitivity to monofilament 2g, confirming the normality of somatosensory sensitivity of the feet.	Will be excluded from the study who were diagnosed with other neurological disease or neuropathic; to have visual impairment or vestibular important and uncorrected, inability to understand for testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-9v9cwf	Interaction between genes of inflammatory mediators and the effects of physical exercise in older women	recruiting	Intervention	2012-01-09	<NULL>	<NULL>	59	Interaction between single nucleotide polymorphisms of the genes of TNF-alpha, IL6, IL10 and brain-derived neurotrophic factor (BDNF) and the effects of physical exercise in older women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-03	Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9v9cwf	<NULL>	Women above the age of 65; community-dwelling	Elderly people with cognitive impairment detectable by the Mini Mental State Examination, acute phase inflammatory disease, tumor growth in the last five years,  current use of immunomodulating medications, amputation or lower limb fracture in the last 6 months, presence of any neurological disease and current participation in an alternative exercise programme.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-74rr6s	PREVER Study: Efficacy of the combination of Chlorthalidone and Amiloride versus placebo in the prevention of hypertension in patients with prehypertension PREVER 1 Study	recruiting	Intervention	2011-03-02	<NULL>	<NULL>	60	PREVER Study: Efficacy of the combination of Chlorthalidone and Amiloride versus placebo in the prevention of hypertension in patients with prehypertension PREVER 1 Study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital de Clínicas de Porto Alegre	FINEP	https://ensaiosclinicos.gov.br/rg/RBR-74rr6s	<NULL>	"I. individuals with 30 to 70 years of age 
II. Systolic Arterial Pressure 120-139 mmHg or Diastolic Arterial Pressure 80-89 mmHg;"	"I. Previous diagnosis of hypertension or use of antihypertensive drugs;
II. Allergies to Chlorthalidone Amiloride;
III. Known cardiovascular disease (previous Miocardial Infarction, previous stroke, heart failure or clinical manifestations, for example, current or previous angina, intermittent claudication ...);
IV. Chronic diseases that limit the participation or the prospect of life (such as cancer, rheumatic disease, disability, etc.);
V. Analgesics or anti-inflammatory use for 30 days or more;
VI. Inability to measure blood pressure;
VII. Difficulty in understanding that limits participation in the study;
VIII. IF WOMEN: Pregnant or planning to become pregnant in the next two years;
IX. Patients who have participated in other randomized trials (the last six months);"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4s7gh3	PREVER Study: Efficacy of Chlorthalidone associated with Amiloride versus  Losartan in reducing blood pressure of patients with hypertension Prever 2 Study	recruiting	Intervention	2011-03-02	<NULL>	<NULL>	61	PREVER Study: Efficacy of Chlorthalidone associated with Amiloride versus  Losartan in reducing blood pressure of patients with hypertension Prever 2 Study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4s7gh3	<NULL>	"I. Individuals with 40 to 70 years, of both sexes;
II. Diagnosis of Hypertension in stage I, ie, systolic (SBP)  between 140-159 mmHg or diastolic blood pressure (DBP) between 90-99 mmHg"	"I. Chronic diseases that reduce life expectancy or difficulty in understanding the guidelines, which limit the possibility of participation in the study;
II. Refusal to participate or sign an informed consent;
III. Pregnancy or women most likely to become pregnant during the study;
IV. Known allergy to any of the study drugs;
V. Prior diagnosis of secondary hypertension ;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-2m9mgq	Evaluation of masticatory function in adult patients with cerebral palsy	recruiting	Observational	2012-01-25	<NULL>	<NULL>	62	Clinical and electromyographic evaluation of masticatory dynamics in adult patients with cerebral palsy	<NULL>	1, n/a, n/a	1	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Odontologia \ UNESP	Faculdade de Odontologia \ UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2m9mgq	<NULL>	"Origin of the volunteers: Patients from ‘Associação Pró-Saúde para Pacientes com Necessidades Especiais’ - ASPE and Training Program in Dentistry for Persons with Disabilities from Dentistry School of São José dos Campos / UNESP.
Type of cerebral palsy: diparetic, quadriparesis or hemiparesis.
Age: from 18 to 50 years old.
Characteristics of participants: no cognitive deficits, collaborative behavior and without treatment of botulinum toxin at least six months before the study begins.
Concordance of the participants and the legal representative to join the study."	"Origin of the volunteers: originating from  other institutions than DentistrySchoolof  São José dos Campos / UNESP .
Type of cerebral palsy: Any paralysis different than quadriparesis, hemiparesis or diparetic.
Age: not adults.
Characteristics of participants: presentingcognitive deficits, not collaborative behaviorand / or under botulinum toxin treatmtentat least six months before the survey.
Lack of agreement of the participant in this study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-32sctf	Effect of elastic bandage on swelling after ankle sprain	not yet recruiting	Intervention	2012-01-26	<NULL>	<NULL>	63	Effect of Kinesio Taping on swelling after ankle sprain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-32sctf	<NULL>	People aged 15 to 45 years with acute ankle sprain.	People who have vestibular disorders or previous neurological or musculoskeletal any change that interferes with or contra-indicate the measurement procedures of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7jq63n	Effect of physical conditioning in patients with spinal cord injury to improve physical endurance.	data analysis completed	Intervention	2012-01-26	<NULL>	<NULL>	64	Effectiveness of aerobic physical training for prevention and treatment of chronic asymptomatic bacteriuria in subjects with spinal cord injury: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7jq63n	<NULL>	Subjects with spinal cord injury between C5 and L2 segments according to the classification of American Spinal Injury Association (ASIA).	individual practitioner of regular physical activity, community ambulators, unable to ride the cycle ergometer with the arms and those who refuse signing the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-6mbrrk	Evaluation of the effect of the treatment with airway positive pressure device on blood pressure levels of  hypertensive patients with sleep apnea syndrome.	recruiting	Intervention	2012-01-26	<NULL>	<NULL>	65	Efficacy of continuous positive airway pressure on blood pressure control of resistant hypertensive patients with obstructive sleep apnea syndrome.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Medicina - Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-6mbrrk	<NULL>	Patients with resistant hypertension and moderate-severe obstructive sleep apnea syndrome	Marked cognitive deficit, non-adherence to anti-hypertensive treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-95j5pm	Effects of supplementation with vitamin D  in patients with chronic kidney disease	recruitment completed	Intervention	2012-01-30	<NULL>	<NULL>	66	Effects of supplementation with vitamin D3 in the cardiovascular system in patients with chronic kidney disease in predialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-95j5pm	<NULL>	Patients in stages 3 and 4 CKD (creatinine clearance between 59 and 15 mL/min/1.73m ²); Both genders; Aged between 18 and 75 years; Patients in the conservative treatment of CKD for at least 3 months; With serum 25 (OH) D3 &lt;30 ng/mL: And who agree to participate.	"Patients with nephrotic syndrome, liver disease, neoplastic, autoimmune or infectious activity and were seropositive for HIV;
Patients who received any supplements or vitamin D analogues, corticosteroids and immunosuppressive drugs in the last 3 months;
Patients with hypercalcemia (ionized calcium&gt; 1.40 mmol/L) and/or serum parathormone (PTH) levels&gt; 500 pg/mL; Patients immobilized in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4hmrph	Assessment in humans of aesthetics and functions of common implants restored with crowns and porcelain metal crowns and porcelain only	recruitment completed	Intervention	2012-01-31	<NULL>	<NULL>	67	Comparative analysis of aesthetic and functional parameters of implant abutments using ceramic and metallic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4hmrph	<NULL>	"of both genders, 
without regard to race, 
aged 18 years and 
need for rehabilitation with crowns and bridges up to two elements of the implant in the anterior region, totaling sixty sites for implants ."	"smoking, 
with systemic diseases, 
need for bone grafting and 
parafunctional habits."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-389mzn	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	recruiting	Intervention	2012-01-31	<NULL>	<NULL>	68	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de São Paulo	Capes	https://ensaiosclinicos.gov.br/rg/RBR-389mzn	<NULL>	presence of vocal tremor to perceptual analysis and larynx; older than 18 years, both sexes	presence of laryngeal spasm during laryngoscopy or auditory perceptual, presence of lesions on laryngoscopy, patients with previous treatment, contraindication to propranolol or botulinum toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4xrgxs	Energy expenditure and cardiovascular response of gait in traumatic lower limb amputees	data analysis completed	Observational	2012-01-31	<NULL>	<NULL>	69	Analysis of energy expenditure and cardiovascular responses while gait in amputees	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-08	Faculdade de Educação Física da Universidade Federal de Juiz de Fora	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4xrgxs	<NULL>	We studied 30 male subjects, 20 with lower limb amputations (10 transfemoral amputees and 10 transtibial amputees) and 10 non-amputee subjects (control group). For the sample, amputees should have been aided more than two years, to walk without gait aids, prostheses using lined with dynamic Sach ® foot and transfemoral, knee own mechanic. All subjects evaluated should not have hypertension, cardiovascular disease, or any pathology that could alter the quality of gait.	All subjects evaluated should not have hypertension, cardiovascular disease, or any pathology that could alter the quality of gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-5fybg2	Investigation of the effect of the consumption of the soluble fiber on the serum cholesterol levels and fractions in children and adolescents.	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	70	Investigation of the effect of psyllium in the process of atherosclerosis juvenile	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Laboratório de Erros Inatos do Metabolismo-  Universidade Federal do Pará	Hospital universitário Pedro Ernesto/UERJ	https://ensaiosclinicos.gov.br/rg/RBR-5fybg2	<NULL>	Inclusion criteria: Children and adolescents (6-19 years) that had a fasting plasma total cholesterol over 170mg/dL (4,40 mmol/L) or LDL-cholesterol over 110mg/dL (2,84 mmol/dL) concentrations, same after were treated initially with similar diet the National Cholesterol Education Program step 1 diet (saturated low-fat diet (&lt;10% calories total) and cholesterol (&lt; 300 mg/dia), for at least eight weeks. The subjects were all outpatients of the Pediatric Nutrition Division and Adolescent Health Studies Nucleus of the Pedro Ernesto University Hospital in Rio de Janeiro, and only those subjects that signed an Informed Consent Form could participated the study.	"Patients with cardiovascular diseases or  or other chronic medical conditions were excluded from the study, as were those whose diabetes.
Children and adolescents with triacylglycerol concentrations of over 3.39 mmol/L or whose Body Mass Index (BMI) according age was higher than 30 kg/m² or female pregnant were also excluded. 
Participants were taking lipid-lowering agents, including hypolipemiant functional foods were also excluded the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-5tmjnd	Effect of physical conditioning in patients with spinal cord injury to increase physical resistance.	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	71	Effectiveness of aerobic physical training applied to patients with spinal cord injury to increase oxygen consumption.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5tmjnd	<NULL>	Individuals with SCI between segments C5 and L2 according to the classification of the American Spinal Injury Association	Individuals who do regular physical activity, community ambulators and individuals who were unable to pedal the cycle ergometer with their arms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7yhzym	Pilates versus conventional physical therapy for patients with chronic low back pain	recruiting	Intervention	2012-01-31	<NULL>	<NULL>	72	Comparison between Pilates and conventional physical therapy for treatment of patients with  nonspecific chronic low back pain: randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-30	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7yhzym	<NULL>	"Medical diagnosis of chronic low back pain
Aged 18 to 55 years"	"Protrusion of intervertebral disc Scoliosis
Spondylolisthesis 
Previous spine surgery
Radicular symptoms (leg pain, loss of sensation and reflexes)
Inflammatory diseases
Rheumatic diseases
Cancer
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-993wz5	High-voltage pulsed current (HVPS) promotes cicatrization of chronic cuaneos ulcers	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	73	Effect of Hight Voltage Pulsate Current on chronic cutaneous ulcers treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Faculdades Integradas Einstein de Limeira	Faculdades Integradas Einstein de Limeira	https://ensaiosclinicos.gov.br/rg/RBR-993wz5	<NULL>	Inclusion criteria was considered both genders, aged between 18 and 80 years and the presence of chronic cutaneos ulcers of any etiology and that no contamination	The presence of wound infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7m3d8w	Influence of an exercise session and a period of physical training on the cardiovascular system of patients with intermittent claudication	recruiting	Intervention	2012-02-01	<NULL>	<NULL>	74	Acute and Chronic Cardiovascular Responses to Exercise in Subjects with Intermittent Claudication	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Ambulatório de Claudicação Intermitente do Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m3d8w	<NULL>	"Men
Aged between 50 and 80 years
Ankle-brachial index lower than 0.9
Peripheral artery disease - level II
Able to walk on a treadmill for at least 2 min at 3.2 km/h
Absence of obesity
Systolic and diastolic blood pressures lower than 160 and 105 mmHg, respectively 
Absence of bypass surgery or angioplasty for at least one year
Not using beta-blockers, non-dihydropyridine calcium channel antagonists or peripheral vasodilators
Absence of leg amputation
Absence of orthopedic problems that contraindicates walking."	"Presence of complex arrhythmias and/or ischemia during exercise
Fasting glycemia greater than 250mg/dl
Presence of autonomic dysfunction"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-54mfjg	Manual Therapy in Head and Neck Pain	recruitment completed	Intervention	2012-02-01	<NULL>	<NULL>	75	Radiographic analysis of the cervical column before and after application of Manual Therapy techniques	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-05	aculdade de Medicina de São José do Rio Preto - FAMERP	aculdade de Medicina de São José do Rio Preto - FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-54mfjg	<NULL>	They presented themselves in possession of radiographs recent segment craniocervical and reported availability and / or appointment to perform evaluation and treatment by a physiotherapist specialist in manual therapy and osteopathy.	individuals who were doing physical therapy procedure in another place of service and / or drug use during treatment, and those that were described in radiography report malfunctions such as fractures, dislocations, severe spinal cord compression, cancer, ischemic processes in the vertebral artery, atheroma , aneurysms, brain and ptosis of rheumatoid arthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-68zp3c	Effects of a physical therapy technique on the feet on the balance of elderly	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	76	Immediate effects of mobilization of the talocrural joint on the static and dinamic balance of elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-04	Universidade Metodista de Piracicaba	Adriana Pertille	https://ensaiosclinicos.gov.br/rg/RBR-68zp3c	<NULL>	"Age between 65 and 80 years; 
Male or female;
Walking without assistive devices for walking;
Normal skin sensitivity in the ankles and feet;
Without cognitive impairment."	"Amputation or use of prosthetic;
Neurological sequelae; 
Fractures in the lower limbs or spine after age 65; 
Severe coronary artery disease;
Labyrinth disease;
Diagnosed neuropathy and foot deformity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-64wczh	Imipramine compared to conservative treatment of urinary incontinence in women urgency.	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	77	Imipramine versus conservative treatment in women with Overactive Bladder Syndrome.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-05-01	Hospital de Clínicas de Porto Alegrte - HCPA	Hospital de Clínicas de Porto Alegrte - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-64wczh	<NULL>	Women older than 18 years, complaining of urge incontinence or mixed (with a major component of emergency)	Pelvic surgery for correction of urinary incontinence less than two years, presence of vaginal or urinary infection, can not understand or sign the informed consent; not understand or are unable to perform the proposed treatment, pregnancy or the postpartum period including the period of six months after delivery; intolerance to the use of imipramine; Urinary Incontinence Mixed Incontinence pure or predominant component of the effort, heart disease, severe liver disease, severe kidney disease with loss of renal function, hyperthyroidism, acute angle glaucoma, epilepsy disease; Parkinson&apos;s disease, uncontrolled hypertension, patients with a history of alcohol or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8dfrpt	Influence of periodontal treatment in periodontitis and diabetes control	recruiting	Intervention	2012-02-01	<NULL>	<NULL>	78	Interaction between chronic periodontitis and type II diabetes:  A randomized clinical trial to study the impact of periodontal treatment on severity of both pathologies by clinical, metabolic, immunology and microbiology parameters	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-25	Universidade Federal de Pernambuco	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-8dfrpt	<NULL>	Diagnosis of type 2 diabetes mellitus; aged 35 years old or more; at least 15 teeth present; clinical and radiographic diagnosis of the presence of chronic periodontitis (AAP, 1999); agreing to participate the study.	Periodontal treatment over the past six months; using antibiotics in the last six months; pregnant women; woman breastfeeding; use of anti-inflammatory chronic form, presence of a systemic condition that might interfere in the course of periodontal disease (immune conditions) or systemic complications of Diabetes Mellitus, smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8nb7xf	A study that evaluates the influence of an exercise program guided and structured combined with sleep hygiene measures on the metabolic changes, sleep disturbances and quality of life in patients with type 2 diabetes.	recruiting	Observational	2012-02-01	<NULL>	<NULL>	79	A Randomized study on the effects of sleep hygiene in glycemic control in patients with type 2 diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	UFC- Universidade Federal do Ceará	UFC- Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8nb7xf	<NULL>	"Know diagnosed type 2 diabetes for at least 6 months.
Men and Woman.
Aged between 40 and 60 years.
Sign the consent term."	"Shift workers
Drug abuse
Hospitalization (past 30 days)
Severe comorbities (renal or hepatic impairment, advanced neoplasia, severe heart failure, severe neurological disorder)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5hkrss	Effect of high-voltage electrical stimulation after carpal tunnel syndrome surgery	recruitment completed	Intervention	2012-02-01	<NULL>	<NULL>	80	Effects of high voltage eletrical stimulation on pain and disfunction in workers with carpal tunnel syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-21	Faculdade de Ciências da Saúde - UNIMEP	Faculdade de Ciências da Saúde - UNIMEP	https://ensaiosclinicos.gov.br/rg/RBR-5hkrss	<NULL>	Female patients, aged between 20 and 60 years, after surgery for carpal tunnel decompression	"Be doing physical therapy at another location; 
miss two or more intervention sessions, without replacement of the lost session."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8zdzkk	Performance evaluation of individuals after stroke and its correlation with the ability to throw weight to the affected side	data analysis completed	Observational	2012-01-31	<NULL>	<NULL>	81	Analysis of functional performance and its correlation with the weight transfer in hemiparetic individuals	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-05-10	Universidade Estadual Paulista Júlio de Mesquita Filho	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8zdzkk	<NULL>	"We included individuals who had independent gait;
Ischemic or hemorrhagic stroke in any territory evidenced by computed tomography (CT);
Age above 30 and below 65 years;
Have hemiplegia or hemiparesis resulting from single and unilateral stroke."	"Cognitive impairment;
Neurological deficit in addition to hemiparesis from stroke;
Osteoarticular complications (fractures, deformities or ankylosis structured;
Time of injury in excess of twelve months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5qffrt	Treadmill walking in subjects with Parkinson&apos;s disease	data analysis completed	Intervention	2012-02-02	<NULL>	<NULL>	82	Effects of treadmill walking training with additional body load in subjects with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qffrt	<NULL>	"Idiopathic Parkinson&apos;s disease, diagnosed by a neurologist experienced in movement disorders, according to the criteria of brain bank in London;
Both sexes aged over 40 and less than 75 years;
In the moderate stage of disease (stages 2 and 3, according to the disability scale of Hoehn and Yahr modified) Use of antiparkinsonian medication;
Walk without any brace or assistive device to walk independently, a walkway of 8 meters (m);
Absence of other neurological disorders, musculoskeletal, cardiovascular and / or breathing that prevent treadmill gait training;
No visual changes and / or uncorrected hearing, that might interfere with the implementation of the Protocol;
Absence of severe cognitive impairment that prevented understanding of simple verbal instructions, as detected by the mini mental state examination;
Not having been subjected to surgery extereotáxica;
Signing the consent form (ICF)."	"Blood pressure (SBP) and systolic and diastolic values above, respectively, 200 mmHg and 110 mmHg before and / or after training;
Heart rate (HR) above the permitted submaximal values, calculated by formula [FCsub = 0.75 x (220 - age)];
Change in dose and / or the type of antiparkinsonian medication during the training period;
Presence of pain and / or severe muscle fatigue that prohibits continued the exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8q4zfh	Relationship between the muscles thigh characteristics and sensory and motor changes for subjects with early degrees of knee osteoarthritis	recruitment completed	Observational	2012-02-13	<NULL>	<NULL>	83	Correlation between vastus lateralis morphology and neuromuscular control for patients with knee osteoarthritis grade I and II	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Paula Regina Mendes da Silva Serrão	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8q4zfh	<NULL>	The following inclusion criteria were used: male, sedentary, aged between 40 and 65 years. All the subjects underwent a radiological examination of both knees to confirm  that they displayed signs of osteoarthritis (OA) (for osteoarthritis group) or not (for control group), such as the presence of osteophytes in at least one of the compartments of a knee joint (tibiofemoral or patellofemoral). In OA group the severity of OA was graded by a radiologist according the Kellgren &amp; Lawrence system. We included in the OAG only those subjects with Grade I or II OA of the knee. In the control group the subjects should not present history of pain, trauma, surgery or fractures of the lower limbs.	The exclusion criteria were: physical therapy (previous 12 months); knee or hip surgery; history of lower limb trauma; corticosteroid infiltration of the knee (previous 6 months); medical condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-4smr5g	Determinants values of fasting glucose and glycated hemoglobin for the dental complications occurrence in patients with type 2 diabetes mellitus	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	84	Determination of fasting glucose and glycated hemoglobin levels preditives to dental complications occurrence in patients with type 2 diabetes mellitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-05-05	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas - Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4smr5g	<NULL>	"Diabetes patients assisted at the Diabetes Clinic of the Division of Endocrinology, Hospital das Clinicas, Faculty of Medicine of Ribeirao Preto / USP (HC-FMRP/USP), and the DAPE Service (Demystifying Dental Care to Patients with Special Needs) School of Dentistry of Ribeirão Preto / USP (FORP-USP)will participate in this study and nondiabetic individuals assisted at the Faculty of Dentistry of Ribeirão Preto - USP (FORP / USP).
 Selected patients will be diagnosed with type 2 diabetes based on the recommendations of the World Health Organization, with progression of the disease at least 5 years, of both sexes, with no predilection for race, over 18 years. Patients must have indication for periodontal dental treatment and/or surgery."	"Type 2 diabetics patients presenting microvascular and macrovascular complications (diabetic retinopathy with vision loss, diabetic neuropathy, diabetic foot + resulting in amputations, coronary heart disease, peripheral arterial disease, cerebrovascular disease, nephropathy developed with the need for dialysis, except for periodontal disease ) patients with systemic or local infectious diseases beyond the mouth, showing malignancy or any other type of disease and drugs that result in immunosuppression, smoking, individuals who have made use of systemic antibiotics in the three months preceding the study.
 Are also excluded patients with diabetes have changes in dosage of medication taken within 3 months prior to dental care.
 The clinical examination will exclude individuals presenting PSR 1 or 2, presenting less than 6 mouth dental elements, individuals with lesions in the oral mucosa, and those who disagree on signing the informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-249vpp	Comparison between the analgesics ketoprofen and parecoxib for pain control after gallbladder surgical removal	data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	85	Postoperative analgesia: comparison between ketoprofen and parecoxib in patients submitted to conventional cholecystectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-10	Pontifícia Universidade Católica de Campinas - PUCCAMP	Pontifícia Universidade Católica de Campinas - PUCCAMP	https://ensaiosclinicos.gov.br/rg/RBR-249vpp	<NULL>	Physical status ASA 1 or 2 patients, undergoing conventional cholecystectomy, of both genders, aged 18 to 55 years old.	"ASA Physical Status 3, 4 or 5.
Patients using hormonal or nonhormonal anti-inflammatory drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-3x64sp	Pilates exercises and breathing in the elderly	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	86	Influence of exercise based on the principles of Pilates respiratory muscle performance in older	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-28	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3x64sp	<NULL>	For inclusion in the sample, the subject should be female and must be between 65 and 80 years; may not have neurological and/or musculoskeletal disorders that preclude the exercises; can not use any assistive mobility device and must present cognitive state compatible with the education evaluated by the Mini Mental State Examination (MMSE).	Will be excluded the elderly woman who refuses to participate in the research, have pain complaints, a hypertensive crisis or syncope during the course of training or miss two training sessions planned.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-6nz2cg	Attention effects on handicap person&apos;s movement	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	87	The effects of attention directed to movement parameters on motor behavior of handicap persons	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nz2cg	<NULL>	"Healthy adults:  history of no muscular injury or not healed on dominant upper limb; no geometrical alterations on dominant upper limb; no reduction on normal joint amplitude of dominant upper limb; do not be overweight or obese.

Handicap adults: to have a minimum of 1yr of medular injury; Level A or B of American Spinal Injury Association (ASIA); realese from physical therapy treatment for a maximum of 2yr; trunk balance sufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; do not have history of muscular injury or not healed on dominant upper limb; do not have geometrical alterations on dominant upper limb; do not have reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; do not be overweight or obese."	"Healthy adults:  to have history of muscular injury or not healed on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; overweight or obesity.

Handicap adults: to have more than 1yr of medular injury; Level C or higher of American Spinal Injury Association (ASIA); realese from physical therapy treatment for more than 2yr; trunk balance insufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; have history of muscular injury not healed or treated on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; overweight or obesity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-7yxnmv	Effects of a technique applied by the hands of the therapist in the thoracic spine in patients with temporomandibular joint and cervical disorders	not yet recruiting	Intervention	2012-02-13	<NULL>	<NULL>	88	Effects of high thoracic spine manipulation on temporomandibular and cervical disorders	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-26	Universidade Metodista de Piracicaba	Delaine Rodrigues Bigaton	https://ensaiosclinicos.gov.br/rg/RBR-7yxnmv	<NULL>	"All volunteers must have:
Diagnosis of temporomandibular disorders (TMD) according to the RDC / TMD (Ia, Ib, IIa, IIb, IIc and IIIa);
Pain and / or fatigue in the masticatory muscles during functional activities for a minimum period of 3 months;
Neck pain for at least 3 months;
Diagnosed with cervical dysfunction according to the neck Disability Index (NDI);
Body Mass Index (BMI) less than 25;
Scores of pain in the masticatory muscles and cervical greater than 3 cm according to the VAS."	"Missing teeth;
Open bite;
Cross bite;
Complete dentures;
Partial systemic neuromuscular diseases;
History of trauma to the face and / or TMJ;
Joint dislocation;
In orthodontic treatment and / or medication actually affecting the musculoskeletal system (pain relievers anti-inflammatories and muscle relaxants);
Red flag as a sign of malignant, infectious or inflammatory disease that contraindicate the use of manual therapy;
Occurrence of cervical whiplash;
Previous surgery of the cervical spine;
Diagnosis of fibromyalgia;
Previous experience with management over the past two months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-4q45r2	Peripheral nerve blocks in patients undergoing shoulder surgery	recruitment completed	Intervention	2012-02-13	<NULL>	<NULL>	89	A comparative study between interscalene brachial plexus block and selective suprascapular and axillary nerve block in arthroscopic shoulder surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-06-15	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4q45r2	<NULL>	Candidates for arthroscopic shoulder surgery; aged between 18 and 80 years old; of either gender; of ASA physical status I or II; with a body mass index below 35 kg/m2; capable of understanding the visual analogue pain scale; and with no medical allergies	Patients who do not accepted participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-42gkzt	Action of low power laser on pain and quality of life and sleep in patients with fibromyalgia	not yet recruiting	Intervention	2012-02-14	<NULL>	<NULL>	90	Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-42gkzt	<NULL>	"A clinical diagnosis of fibromyalgia based on American College of Rheumatology criteria;  
Cognitive level sufficient for understanding the procedures and following the instructions; 
Agreement to participate in the study and the signing of a statement of informed consent after receiving clarifications regarding the objectives of the study."	"Psychiatric disorders, history of drug abuse or other behaviors that require intervention psychiatric medication;
 Development of uncontrolled clinical situations that prevent participation in aerobic activities, for efforts or group activities;
 History of epilepsy, seizures, heart disease and arrhythmias;
 A pacemaker;
 Presence of undiagnosed pain;
 Pregnant women;
 Patients with malignant tumors."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8m444q	Evaluation of anesthesia in cardiac surgery patients	not yet recruiting	Intervention	2012-03-09	<NULL>	<NULL>	91	Evaluation of the analgesic efficacy of general  and spinal anesthesia with morphine associated ropivacaine in patients who underwent surgery type coronary artery bypass grafting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-15	Universidade Federal do Rio Grande do Norte	Promater Hospital Geral	https://ensaiosclinicos.gov.br/rg/RBR-8m444q	<NULL>	"Assessment of the physical status;
Anesthetic risk classification according to the American Society of Anesthesiologists (ASA) ASA II and III;
The indication of coronary artery bypass grafting;
Verbal skills and understanding appropriate to participate in the interview; - No pain preoperatively."	"Manifestation of the patient and / or guardian&apos;s desire not to continue in the study;
Present severe postoperative complications such as respiratory and heart failure, valvular heart disease associated procedures and emergencies, reoperation;
Other disorders pre-operative treatment with heparin, since it may affect patients&apos; responses to questions about pain."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6kcc3w	Eteitos training on ramps on the walking pattern of individuals who have suffered stroke	data analysis completed	Intervention	2012-03-30	<NULL>	<NULL>	92	Effects of gait training on sloping surfaces in the gait of individuals with chronic hemiparesis - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal do Rio Grande do Norte- UFRN	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6kcc3w	<NULL>	Time after stroke: more than six months, One-sided hemiparesis,No heart disease, No orthopedic impairment or other neurological impairment that may change the gait, Can mind simple verbal commands, Can wlak anlone or with canes and have being classified by functional ambulation category (FAC) at levels 3 to 5, Spasticity  dagreemild to moderate  in the affected lower limb with levels of classification between 0 and 2 in the Ashworth spasticity scale modified,  70 years Maximum age.	Heart frequency increase more than 75% of the maximum or have any other general instability  during training that may mean risk for the same practice, Lack of training sessions to more than two, when they are consecutive, or more than three, when they are changed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6d342s	Insoles for use of assistance for everyday tasks in children with cerebral palsy.	not yet recruiting	Intervention	2012-05-08	<NULL>	<NULL>	93	Insoles postural functionality of children with cerebral palsy randomized controlled trial.	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-05-15	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6d342s	<NULL>	To participate in the study, the children will be diagnosed with cerebral palsy, ranked among the levels of the GMFCS I and II and have to walk independently without the need for auxiliary resources (walker or crutches).	Children with CP who have undergone surgical procedures or the application of phenol in the last 12 months or neurolytic blocks in the last six months, children with cognitive and visual disabilities that may interfere with the performance of tasks, children with deformities of the ankle is not reducible to neutral and obese children.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-4njyw9	Effects of fish oil supplementation  on pre diabetes in patients with chronic hepatitis C.	recruiting	Intervention	2012-06-05	<NULL>	<NULL>	94	Effects of omega 3 fatty acids supplementation  on insulin resistance in patients with chronic hepatitis C.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-05	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4njyw9	<NULL>	Adults (age &gt; 18 years) diagnosed with chronic hepatitis C (genotype I); either non responders or naive patients; alcohol consumption &lt; 40g/dia; HOMA index &gt; 2.5; Signature of term consent	Diabetics or those using drugs to alleviate insulin resistance, co-infected (HIV or HBV), hepatitis with autoimmune or use of antiviral treatment (interferon and ribavirin), decompensated liver disease or patients with hepatocellular carcinoma; With other neoplasias; Patients with chronic renal failure or decompensated heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7bqxm2	Expenses and benefits  of a physical activity program in chronic obstructive pulmonary disease	data analysis completed	Intervention	2012-06-18	<NULL>	<NULL>	95	Assessment of costs and benefits of a physical activity program for Chronic Obstructive Pulmonary Disease: implementation and Primary Care Units in the SUS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-06	Universidade Federal  do Rio Grande do Norte - UFRN	Universidade Federal  do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7bqxm2	<NULL>	"In medical treatment by a pulmonologist;
 Age between 40 and 85 years;
 Do not make use of oxygen;
 No exacerbations in the last three months;
 Do not be practicing regular physical activity over the past six months."	"Musculoskeletal comorbidities that interfere in the running;
 Decrease the peripheral oxygen saturation (SpO2) &lt;90% during the submaximal exercise test;
 Difficulty in understanding intellectual who prevented them from carrying out the assessment activities;
 Abandoning the practice of physical activity proposed;
 Did not attend for reassessment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-445br3	Evaluation of Drug Treatment Adherence of Patients With Mental Disorders.	recruitment completed	Intervention	2012-04-23	<NULL>	<NULL>	96	Evaluation of Pharmacotherapy Adherence of Patients Attended to Pharmaceutical Service in a Psychosocial Care Center.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de Sergipe	Secretaria Municipal de Saúde de São Cristóvão	https://ensaiosclinicos.gov.br/rg/RBR-445br3	<NULL>	Individuals over 18 years. Diagnosed with schizophrenia, schizotypal and delusional disorders. Which are in treatment for at least six months. For which pharmacotherapy was prescribed; Those who accepted participate in the study by signing a Statement of Informed Consent.	Patients who are in crisis. Patients who have psychiatric symptom associated with a diagnosis inconclusive or not yet elucidated. Patients who have evidence or diagnosis of neurological or cognitive damage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-3x57fj	Analgesic and adjuvant anesthetic effect of tramadol after third molar surgery	data analysis completed	Intervention	2012-05-17	<NULL>	<NULL>	97	Postoperative analgesia and  anesthetic effect of local tramadol chloridrate injection after oral surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-02	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x57fj	<NULL>	Both gender, above 18 years of age, necessity of removal of inferior impacted third molars, symetric and bilateral	"In use of analgesic or anti-inflammatory drugs before 24 hours treatment, history of seizure, pregnancy, 
lactation, history of psychiatric illness, allergy to the drugs used in this study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7tmkv9	Italian Study on Sleep and Heart Failure	recruiting	Observational	2012-12-11	<NULL>	<NULL>	98	Italian Multicenter Project Sleep and Heart Failure	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7tmkv9	<NULL>	Patients with heart failure who agree to participate in the study; both gender; age between 19 and 90 years; cognitive level sufficient to understand the procedures and follow the instructions; stable clinical conditions for at least four weeks and optimized medical therapy; assigned consent form.&quot;	Individuals with HIV; renal failure with the calculation of filtered under 30ml/minutes; malignant neoplasm; abuse of alcohol and or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6gdyvz	Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women	recruiting	Intervention	2012-12-12	<NULL>	<NULL>	99	Effects of Different Models of Undulating Periodization of Resistance Training on Cardiovascular Risk Parameters, Body Composition, Muscle Strength and Lifespam in Premenopausal Women with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-10	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6gdyvz	<NULL>	To be pre-menopausal aged between 18-49 years and no regular practice of exercise in the previous 12 months	Use of drugs that could affect cardiovascular response to exercise and presence of any disease that would compromise their health during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-5qcvv9	Randomized, Double-Blind, Phase 3 Trial to Compare the Efficacy of Ipilimumab vs Placebo in Asymptomatic or Minimally Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer	recruitment completed	Intervention	2011-11-13	<NULL>	<NULL>	100	Randomized, Double-Blind, Phase 3 Trial to Compare the Efficacy of Ipilimumab vs Placebo in Asymptomatic or Minimally Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-07-28	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-5qcvv9	<NULL>	Metastatic prostate cancer. Asymptomatic or minimally symptomatic. Progression during hormonal therapy. ECOG Performance Status 0-1	Liver, lung or brain metastases. Prior immunotherapy or chemotherapy for metastatic prostate cancer. Autoimmune disease. HIV, Hepatitis B, or Hepatitis C infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9tcn2x	Electroacupuncture and Manual Acupuncture in Patients With Knee Osteoarthritis	recruiting	Intervention	2012-11-29	<NULL>	<NULL>	101	Electroacupuncture and Manual Acupuncture in Patients With Knee Osteoarthritis: Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Cidade de São Paulo	Ralph Plaster	https://ensaiosclinicos.gov.br/rg/RBR-9tcn2x	<NULL>	Pacients with knee pain, with minimal intensity 2 in visual analogic scale (0-10); Radiographic exam showing knee ostearthritis degree II, III or IV accordingly Kelgren and Lawrence classification	Patients with a history of cancer; dementia; neurological deficits (sensory or motor); cardiac pacemaker; decompensated type I diabetes; uncontrolled systemic arterial hypertension; morbid obesity; currently taking antidepressants; anti-inflammatory steroids in the last six months; tranquilizers; and that are currently under physiotherapy sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9bwgr9	Effect of adhesive usage in complete denture wearers	recruitment completed	Intervention	2012-11-30	<NULL>	<NULL>	102	Effect of using an adhesive in conventional complete denture wearers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-10	Universidade Estadual Paulista Júlio de Mesquita Filho	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bwgr9	<NULL>	Adults; mentally agile and responsive; with resilience and alveolar volume normal; absence of dysfunctions in the stomatognathic system and the absence of debilitating systemic changes	Debilitating neurological or systemic diseases and the need for pre-prosthetic surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-3s9m65	The Importance of Physical Exercise in Balance and Gait With or Without Another Task in The Elderly	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	103	The Influence of Physical Exercise on Postural Control and Gait pattern Associated or not to The Dual-task	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-12	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Hospital de Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3s9m65	<NULL>	Healthy older, between 60 and 80 years, living in the community	Presence of cardiovascular, neurological or vestibular diseases, presence of musculoskeletal problems that interferes with static or dynamic balance, peripheral neuropathies, use of medication for central nervous system, mini-mental State Examination (MMSE) score less than 23	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-8fs5ww	Comparison between two molding techniques in removable partial dentures	data analysis completed	Intervention	2012-11-09	<NULL>	<NULL>	104	A clinical study comparing the technique of forming functional model changed and direct functional impression technique for removable partial dentures free distal end	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-26	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8fs5ww	<NULL>	The Patients must have been rehabilitated in the clinic of the Department of Dentistry degree UFRN be carriers of Removable Prosthodontics Total Upper arch and Removable Partial Denture Lower arch with bilateral posterior free end (Kennedy Class I). The minimum age required to participate in the study will be 18 years and included patients of both genders.	Patients with weakened health care unable to attend; patients with normal classification according to bone height that have less than five or more than eight lower teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-8qkx34	Comparison between different methods of strength training on muscle adaptations and functional performance in older women	recruitment completed	Intervention	2012-11-13	<NULL>	<NULL>	105	Comparison of methods for determining the load and speed of executation of strength training on neuromuscular adaptations and performance of functional perfomance in older women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal do Rio Grande do Sul	Faculdade da Serra Gaúcha	https://ensaiosclinicos.gov.br/rg/RBR-8qkx34	<NULL>	Women aged between 60 and 75 years. Not strength training practitioner at least 12 months. Not practicing regular exercise with weekly frequency equal to or exceeding twice. Low to moderate levels of physical activity. Apparently healthy, without involving the neuromuscular system, cardiovascular and endocrine. Medical certificate agreeing with the practice of strength training. Lack of use of any medication with influence in the neuromuscular system.	Change in health condition established by medical certificate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7tyg5j	Effectiveness of the Pilates method performed in the equipament or in the mat	recruitment completed	Intervention	2012-02-13	<NULL>	<NULL>	106	Effectiveness of the Pilates method performed in the equipament or mat Pilates in the treatment of chronic non-specific low back pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-10	Universidade Cidade de São Paulo	CRISTINA MARIA NUNES CABRAL	https://ensaiosclinicos.gov.br/rg/RBR-7tyg5j	<NULL>	Patients with low back pain longer than three months, of both gender and aged between 18 and 60 years.	The following criteria will be considered as exclusion: participants involved with the Pilates method regularly, pregnancy, previous surgery of the spine and lower limbs, history of spinal fracture, inflammatory disorders, rheumatic and neurological disorders, systemic metabolic disease, herniated disk, tumor, infection, osteoporosis, structural deformity , serious nervous commitment, do not understand the writing and speaking of the Portuguese language and participants who underwent physical therapy for chronic low back pain in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-48tgdd	Using a low cost resistance exercise protocol in patients with chronic obstructive pulmonary disease	recruitment completed	Intervention	2012-05-30	<NULL>	<NULL>	107	Physical, functional and quality of life in patients with chronic obstructive pulmonary disease in a program of strength training with elastic tubing	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-16	Faculdade de Ciências e Tecnologia FCT/UNESP	Faculdade de Ciências e Tecnologia FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-48tgdd	<NULL>	"Diagnosis of Chronic obstructive pulmonary disease (COPD) confirmed by spirometry according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria; 
Age over 50 years; 
Absence of associated pulmonary diseases."	"Occurrences of clinical instability; 
Cardiac co-morbidities that would prevent musculoskeletal execution of the experimental protocol; 
Congestive heart failure; 
Diabetes; 
Rheumatoid arthritis and presence of other systemic inflammatory diseases; 
Irregular participation on the experimental protocol"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-49sk2j	Evaluation of progressive air trapping during exercise in pacients with lymphangioleiomyomatosis and response to bronchodilator	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	108	Evaluation of dynamic hyperinflation in patients with lymphangioleiomyomatosis (LAM) using cardiopulmonary exercise testing and study of response to bronchodilator	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2010-01-06	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-49sk2j	<NULL>	"All patients followed in the outpatient setting of pulmonary division of Hospital das Clinicas - University of Sao Paulo Medical School, with the following inclusion criteria:
1) Diagnosis of LAM (clinico-radiological or histological) 
2) Absence of instability (no exacerbation or hospitalization, for pneumothorax or chylothorax, for example, in the last 6 weeks)"	"Previous lung transplant
Muscular or bone disorder who prevents performing exercise
Serious or unstable cardiopathy (functional class IV)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-73vbv8	Physiotherapy in patients of abdominal surgery.	data analysis completed	Intervention	2012-12-20	<NULL>	<NULL>	109	Effects of preoperative physiotherapy in cardiorespiratory conditions and physical functioning of patients undergoing upper abdominal surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-10-27	Pontifícia Universidade Católica de Campinas	Silvia Maria de Toledo Piza Soares	https://ensaiosclinicos.gov.br/rg/RBR-73vbv8	<NULL>	"Patients with over 40 years of age.
Scheduling of upper abdominal surgery elective (including surgery of  esophagus, stomach or biliary tract surgery).
Patients in preoperative elective period, at least 15 days and up to 21 days in advance of surgery.
Physical and mental conditions that permit the evaluation of pulmonary function and walking test acceptable before surgery.
Patients who signed an informed consent forms."	"Patients with cerebrovascular or neuromuscular disease.
Patients on immunosuppressive therapy before surgery.
Prior pulmonary surgery history.
Patients that had previously undergone surgery of the esophagus, stomach or biliary tract.
Cardivascular instability.
Patients undergoing physiotherapy in the eight weeks before inclusion in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-24t799	Effect of cleaning teeth in the levels of c-reactive protein in the blood of patients with severe disease in teeth and bone of the maxilla and mandible	data analysis completed	Intervention	2012-09-28	<NULL>	<NULL>	110	Effect of nonsurgical periodontal therapy on levels of c-reactive protein in serum of subjects with severe periodontitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-12	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-24t799	<NULL>	Subjects with periodontitis; Periodontitis group: 19 women, nine men; with at least 18 teeth in upper or lower dental arch; be aged a minimum of 20 and maximum of 45 years; no radiographic evidence of bone loss.	History of smoking; pregnancy or lactation; periodontal therapy; antimicrobial therapy for systemic conditions or use of topical oral antibiotics in the last twelve months; diabetes; autoimmune disease; active acute infections; active severe allergies; active gastrointestinal diseases; active renal diseases; active cancer; morbid obesity (Body mass index -BMI-  &gt;40 kg/m2) or underweight (malnourished BMI &lt;18.5 kg/m2); use of medications in the last twelve months that alter the levels of inflammatory mediators.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6ck4gv	Effects of an exercise program in patients with sequelae of stroke	data analysis completed	Intervention	2012-07-09	<NULL>	<NULL>	111	Effects of Square Stepping Exercise in patients with sequelae of stroke	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp	Centro Universitário Hermínio Ometto - uniararas	https://ensaiosclinicos.gov.br/rg/RBR-6ck4gv	<NULL>	Age 50 to 80 years, unilateral cerebrovascular lesions, and only 12 months before the start of the intervention, supported by computed tomography or magnetic resonance imaging of the brain, ability to understand verbal instructions and ability to walk without assistance or with prosthetic or orthoses (canes, crutches)	Orthopedic and neurological disorders prior stroke and clinical instability associated with severe systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6sz5dj	Use of two physiotherapeutic techniques internade the patient in the intensive care unit	recruitment completed	Intervention	2012-07-09	<NULL>	<NULL>	112	Use of de game therapy to assess functionality and upper limb muscle strength in critical patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-31	Instituto de Neurologia de Curitiba	Faculdade Inspirar	https://ensaiosclinicos.gov.br/rg/RBR-6sz5dj	<NULL>	"ICU; 
With a minimum age of 16 years; 
Value of Glasgow Coma Scale equal to 15; Value of handgrip dynamometry below normal for their age and sex; 
Able to actively carry out the proposed activity; 
Absence of thrombosis in upper limbs, fractures, dislocations, muscle strains or ligament that required the use of immobilizers, or that would unable to mobilize to the upper limbs;
Thoracotomy absence of recent (less than 40 days); 
Absence of visual impairment (blindness); Do not be pregnant; 
Absence of upper-limb amputation; 
Absence of diagnosis of neuromuscular disease, trauma, spinal cord tumors or abscesses, hemiplegia / paresis, encephalopathy plexus injury or brain"	"Hemodynamically unstable patients with MAP &lt;60 mmHg or&gt; 130 mmHg; 
Refusal to do one or two daily sessions of the proposed activity; 
Decreased level of consciousness;
Use of other materials such as halter, bat and ball and it worsened by 30% in value after revaluation dynamometry every 7 days of intervention"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6ybpz5	Evaluation of Thermography in the Diagnosis of RSI in the wrist joint.	recruitment completed	Observational	2012-07-13	<NULL>	<NULL>	113	Evaluation of Thermography in the Diagnosis of RSI in the wrist joint.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-09-09	Pontificia Universidade Catolica do Parana- PUC- PR	Pontificia Universidade Catolica do Parana- PUC- PR	https://ensaiosclinicos.gov.br/rg/RBR-6ybpz5	<NULL>	"Individuals of both sexes
Adults aged at least 20 years 
Individuals who performed the activity of typing during your workday
Pain complaints in the wrist joint, carpal and metacarpal
Pain intensity from grade"	"Rheumatic diseases
In treating inflammatory diseases
In use of analgesic drugs and / or inflammatory
Age above 50 years"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-4g7q2c	Effects of a program of strengthening exercise in subjects with Parkinson&apos;s disease	recruitment completed	Intervention	2012-07-16	<NULL>	<NULL>	114	Strengthening exercise in individuals with parkinson´s disease: A randomised trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-15	Universidade Federal de Minas Gerais-UFMG	Universidade Federal de Minas Gerais-UFMG	https://ensaiosclinicos.gov.br/rg/RBR-4g7q2c	<NULL>	"Are older than 50 years of age;
Have a diagnosis of PD; 
In stages I to IV of the Disability Stages of Hoehn &amp; Yahr;
Be stable use of anti-parkinsonian;
Have good comprehension (assessed using the Mini Mental State Examination score);
Signing the informed consent"	"Adverse medical conditions that may prevent participation in the proposed protocols as decompensated hypertension, neurological diseases or other rheumatic diseases of any kind;
Individuals who are in physical therapy for at least 02 months before the randomisation procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7nqxy5	Evaluation of the ability of different methods and measures in critically ill patients to check the possibility of withdrawal of mechanical ventilation	data analysis completed	Intervention	2012-06-18	<NULL>	<NULL>	115	Serial measurements before and after extubation of the index of rapid shallow breathing as a predictor of extubation failure in patients on prolonged mechanical ventilation	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7nqxy5	<NULL>	"All patients admitted to the ICU during the period of the study;
Largest 18 years;
In use of the orotracheal tube over 72 h;
In process of weaning from mechanical ventilation;"	"Patients with a history of tracheal or laryngotracheal;
Patients tracheotomized;
Patients extubated accidentally;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-5yc53k	Influence of strength training performed alone or associated with functional training on the cardiovascular system of elderly patients with Parkinson Disease.	recruiting	Intervention	2012-06-19	<NULL>	<NULL>	116	Effect of resistance training performed alone or associated with functional training on cardiovascular function and autonomic modulation in elderly patients with Parkinson Disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-27	Escola de Educação Física e Esporte da Universidade de São Paulo	Centro de Estudos em Psicobiologia e Exercício da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5yc53k	<NULL>	"45 Individuals with Parkinson&apos;s disease in stages from I to III assessed by the Hoehn and Yahr scale
15 Elderly subjects without Parkinson
Both genders
Aged above 60 years
Sedentary
Normotensive (systolic and diastolic blood pressure less than 140 and 90 mmHg, respectively)
No cardiovascular diseases or muscle-skeletal disorders
Not using medications that alter cardiovascular parameters, except in medications for treatment of Parkinson&apos;s disease"	Presence of complex arrhythmias and/or ischemia during exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9vw39v	Treatment of female urinary incontinence with electrical stimulation of vaginal muscle and evaluation of vaginal pH	recruitment completed	Intervention	2012-06-28	<NULL>	<NULL>	117	Stress urinary incontinence: treatment with intravaginal electric stimulation and vaginal pH evaluation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Estadual de Campinas (UNICAMP)	PUC Minas	https://ensaiosclinicos.gov.br/rg/RBR-9vw39v	<NULL>	women with clinical symptoms of stress urinary incontinence and mixes urinary incontinence	Women with the presence of an intrauterine dispositive, heart pacemaker, use of hormonal therapy, use of antibiotics, use of an intravaginal drug, urinary tract infection for less than two weeks, vaginal infection, severe pelvic organ prolapse (grade III), pregnancy, postpartum, leucorrhea, itching, pelvic pain, vulvar irritation, and/or other vaginal symptoms that could interfere with the results,urethral obstructions, neurogenic detrusor overactivity and detrusor hypocontractility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7tf6tm	Treatment of the lower limb pain, which arise during the walks, for lack of circulation. Through temporary circulation interruption of upper limbs.	data analysis completed	Intervention	2012-06-28	<NULL>	<NULL>	118	Remote ischemic preconditioning in patients with intermittent claudication	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tf6tm	<NULL>	this study recruited patients complaining of typical intermitent claudication (IC) in one or both lower limbs, associated with absence or reduction of arterial pulses in the symptomatic member and/or ankle-brachial index &lt; 0.90. Physical examination of the upper limbs was normal in all study participants.	"Arterial occlusion of both upper
 Presence of critical ischemia of lower limbs, characterized by pain at rest or ischemic ulcerations existence of the same.
 Inability to perform the treadmill test for reasons other than the intermittent claudication, as changes rheumatologic, orthopedic, neurological, cardiac or respiratory
 Having used the following drugs in the last two hours before inclusion in the study: cilostazol, sildenafil, dipyridamole, glibenclamide, aminophylline, nicorandil, phenylephrine, angiotensin-converting enzyme inhibitors, angiotensin receptor blocker II, statins, alcohol, steroids, red wine.
 Having consumed a quantity of coffee that means a caffeine intake ? 4mg/kg (approximately 400 ml of coffee brewed in coffee maker) in the last two hours prior to study entry"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-3wwt53	Effect of neural mobilization on the vertical jump and balance in healthy subjects	not yet recruiting	Intervention	2012-06-05	<NULL>	<NULL>	119	Effect of neural mobilization in the lower limbs on the vertical jump and balance in healthy subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-20	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3wwt53	<NULL>	Men and women, aged between 18 and 45 years, that do not have previous neurological or vestibular disorders, musculoskeletal or any change that interferes with or contra-indicate the measurement procedures of this study	Underage individuals and individuals with vestibular disorders, neurological or musculoskeletal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-4bxdhb	Prevention of nausea and vomiting after surgery for stomach reduction in obese individuals.	data analysis completed	Intervention	2012-06-05	<NULL>	<NULL>	120	Prevention of nausea and vomiting in obese patients undergoing laparoscopic bariatric surgery: A comparison between three schemes.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4bxdhb	<NULL>	"Patients aged between 18 and 65 years;
 Obese patients with body mass index (BMI) greater than or equal 35 kg/m2;
 Classified as physical status I-III of the American Society of Anesthesiologists (ASA); 
 Candidates for bariatric surgery, like laparoscopic sleeve gastrectomy under balanced general anesthesia"	"Hypersensitivity or contraindication to study drugs;
Serious complications in the perioperative period; 
Psychiatric disorder and a history of migraine;
Used opóide, anti-inflammatory hormone and anti-emetic medication 24 hours prior to surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6j2vvr	Assessment of static balance in lower limb amputees	data analysis completed	Observational	2012-06-15	<NULL>	<NULL>	121	Static stability evaluation in subjects with unilateral transtibial amputation traumatic.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6j2vvr	<NULL>	"Amputees prostheses for more than one year and not amputated;
Ability to walk without assistive devices for walking;
Use prosthesis aligned with dynamic Sach ® foot."	Hypertension, cardiovascular disease, or any condition that alters the quality of gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7yhr4w	Study of lung function, and sleep, and daytime sleepiness, and the behavior of the autonomic nervous system, and anxiety, depression, and stress in  chronic renal failure patients.	not yet recruiting	Intervention	2012-06-15	<NULL>	<NULL>	122	Study of lung function, and maximal ventilatory pressures, and sleep, and daytime sleepiness, and nocturnal periodic legs moviments, and autonomic nervous system activity, and ansiety, and depression, and stress vulnerability, in chronic kidney disease patients.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-02	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7yhr4w	<NULL>	"Patients with chronic renal failure candidates to  renal transplant with an indication of hemodialysis, that agree to participate in the study; 
Both gender;
Aged between 18 and 70 years;
Cognitive level sufficient for understanding the prodedures and fllowing the instructions."	Abuse of alcohol and or drugs;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-35rp8x	Training and reaching in infants	recruiting	Intervention	2012-05-27	<NULL>	<NULL>	123	Influence of training on reaching ability in infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Federal University of São Carlos	Federal University of São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-35rp8x	<NULL>	To meet the eligibility criteria, infants had a birth weight between percentiles 10 and 90 on the growth curve, Apgar scores greater than or equal to seven in the first and fifth minutes, adequate motor performance according to the Alberta Infant Motor Scale (AIMS), were in maternal care and not in day care centers.	Infants who are born with gestational age less than 37 weeks, low birth weight (below 2500g), with Apgar score below seven in the first and fifth minutes of life and those who submit, congenital central nervous system, signs neurological, musculoskeletal changes, diagnosis of genetic syndromes or symptoms of withdrawal symptoms associated with maternal report of abuse of alcohol and drugs, congenital infections, sensory deficits, cardiopulmonary difficulties or whose mothers have submitted episode of eclampsia or preeclampsia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2bc4gk	Use of horses on improvement functional capacity of elderly	data analysis completed	Intervention	2012-05-28	<NULL>	<NULL>	124	Hippotherapy on functional capacity of elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Faculdade de Educação Física Universidade de Brasília-UnB	Instituto Cavalo Solidário	https://ensaiosclinicos.gov.br/rg/RBR-2bc4gk	<NULL>	"Ability to understand simple commands; Perform activities of daily living independently; 
Mount the horse independently (with help of the platform mount)
Submission of a medical certificate to practice the activity of riding a horse"	"Body weight greater than 90 kg, 
The animal Phobia"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-8v3tkq	Clinical trial to evaluate the effectiveness and safety of the laser to control the pain caused by orthodontic treatment	data analysis completed	Intervention	2012-05-28	<NULL>	<NULL>	125	Evaluation of low level laser terapy(LLLT) for the treatment of pain associated with positioning elastomeric orthodontic interdental separators	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-28	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-8v3tkq	<NULL>	"Chronological age greater than 12 years; 
Presence of erupted permanent first and second lower molars; Presence of erupted first and second premolars; 
Voluntary participation in the study confirmed by signing the informed consent form."	"Patients using antibiotics or analgesics; 
Pregnant or breastfeeding women; 
Patients with cardiac disease; 
Systemic diseases; 
Contraindications for NSAIDs use; 
Surgical procedure during the preceding two weeks; 
Gastrointestinal illness (gastritis, gastric ulcer, lactose intolerance, chronic diarrhea or intestinal inflammatory illness); 
Melanin pigmentation in the gingiva in the area to be irradiated;
Treated or untreated apical bone lesions; 
Diastema in the region of the molars and/or premolars."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-9vc722	The interference of the nail polish on oxygenation in patients with lung disease in exercise.	recruitment completed	Intervention	2012-05-30	<NULL>	<NULL>	126	Evaluation of interference of finger nail polish on peripheral oxygen saturation in patients with pulmonary disease at rest and during exercise.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9vc722	<NULL>	"Patients with stable chronic obstructive pulmonary disease (COPD);
Current non-smokers;
Both sexes;"	"Heart disease (heart failure, arrhythmia); Musculoskeletal disease; 
Scleroderma;
Onychomycosis;
Hemoglobin (Hb) less than 13.5 g / dl for men and 12,0g/dl for women, or greater than 17.5 g / dl for men and 16.5 g / dl for women; 
Hematocrit (Hct) less than 40.5% for men and 36.0% for women or greater than 52.0 % for men and 48% for women;
Bilirubin less than 0.4 mg / dl or greater than 1.2 mg / dl for both sexes; 
Sistemic arterial hypertension; 
Abnormal peripheral perfusion with Capillary refill &gt; 3s; 
Carbon monoxide levels (CO) equal to or greater than 10ppm."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7v2vvt	The use of carbon dioxide (CO2) as a contrast medium for performing endovascular procedures	recruiting	Intervention	2012-05-11	<NULL>	<NULL>	127	The use of carbon dioxide (CO2) as a contrast medium for performing endovascular procedures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Hospital Israelita Albert Einstein	Hospital Municipal M'boi Mirim - Dr. Moysés Deutsch	https://ensaiosclinicos.gov.br/rg/RBR-7v2vvt	<NULL>	Patients with critical lower limb ischemia resulting from arterial disease morphology TASC A or B  or abdominal aortic aneurysms with an indication for the correction ; Agreement and signing the informed consent.	Contraindications to any of the types of procedures either by the technique used, type of contrast or medical reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6w9nfq	Effects of the combination of visual or auditory cues to treadmill gait training of individuals who have suffered stroke	data analysis completed	Intervention	2012-05-11	<NULL>	<NULL>	128	Influence of biofeedback in gait training on a treadmill with partial body weight support in hemiparetic subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6w9nfq	<NULL>	"Chronic stage of stroke (time of injury over 6 months); 
Hemiparesis; unilateral brain lesion and non-recurring, mild to moderate spasticity, with level 1 or 2 of the modified Ashworth scale;
Ability to ambulate functionally, with some assistance or personal with the use of assistive devices for walking, levels 4 and 5 of the protocol Functional Ambulation Category - FAC; 
Idling (slower than 0.4 m / s) or moderate (speed from 0.4 to 0.8 m / s) according to the classification of gait based on speed;
Absence of cognitive impairment, from the score of the Mini Mental State Examination (MMSE);
Absence of other neurological or orthopedic pathologies that lead to functional sequelae than those brought by stroke or disability visual and/or hearing loss that adversely affects the training of biofeedback."	"Instability in the cardiovascular condition during training;
Lack of understanding of instructions for carrying out training"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-4tbd4p	Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.	recruiting	Intervention	2012-05-11	<NULL>	<NULL>	129	Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-4tbd4p	<NULL>	"In medical treatment-outpatient for at least six months;
Clinical picture stable for three months; Optimized drug therapy."	"Heart disease associated with pulmonary disease; 
Musculoskeletal pathology that may interfere with the conduct of reviews or exercises;
Pulmonary hypertension;
Difficulty to learn."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-9vpm9c	Cooling as an adjuntive therapy to angioplasty in patients with myocardial infarction.	not yet recruiting	Intervention	2012-05-21	<NULL>	<NULL>	130	Cooling as an adjuntive therapy to percutaneous intervention in patients with acute myocardial infarction - &quot;cool-mi incor&quot; - version 2.0, february 2011.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	ZOLL CIRCULATION INC	ZOLL CIRCULATION INC	https://ensaiosclinicos.gov.br/rg/RBR-9vpm9c	<NULL>	Patients aged&gt; 18 years; The patient must have symptoms consistent with acute myocardial infarction (chest pain, or arm pain, etc.) and no improvement with nitroglycerin with onset of symptoms more than 30 minutes but less than six hours before its entry in the emergency room; Anterior wall AMI or less with ST segment elevation&gt; 1 mm in two or more contiguous leads; The patient must be eligible for the PCI; The expected time until the patients undergoing PCI should allow at least 30 minutes of cooling before PCI; The patient or legal guardian of the patient agrees and is willing to sign the informed consent to participate in the clinical study.	The patient had a previous myocardial infarction within one month; The patient has cardiogenic shock (systolic blood pressure (SBP) &lt;80 mmHg and unresponsive to volume or SBP &lt;100 mmHg with vasopressors, or need for an intra-aortic balloon - BIA); The patient has known hypersensitivity to hypothermia, including a history of Raynaud&apos;s disease; The patient has known hypersensitivity or contraindication to aspirin, heparin, or hypersensitivity to contrast that can not be adequately premedicated; The patient has known history of blood diathesis, coagulopathy, cryoglobulinemia or sickle cell anemia, or refuse a blood transfusion; The patient has a height &lt;1.5 m (4 feet 11 inches); The patient is known to be pregnant or expect to become pregnant before 1 month of follow-up; The patient has known hypersensitivity to buspirone or meperidine hydrochloride and / or treated with a monoamine oxidase inhibitor in the last 14 days; The patient has known history of hepatic or renal impairment, untreated hypothyroidism, Addison&apos;s disease, benign prostatic hypertrophy or urethral stricture, which in the opinion of the physician, would be incompatible with the administration of meperidine; To prevent nephrotoxicity gadolinium, patients with renal failure known as a set Glomerular Filtration Rate of less than 30 cubic centimeters per minute; Patients with vena cava filter; The patient has a life expectancy of pre-MI &lt;1 year due to underlying medical conditions or pre-existing comorbidities; The patient has known history of drug or alcohol addiction, or is unable to understand or follow the instructions; The patient is currently enrolled in the study COOL-MI or other drug research or study device that has not completed the primary endpoint or that clinically interferes with the outcomes of the COOL-MI study INCOR.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-27rmv3	Effect of mirror therapy in upper limb of young individuals with cerebral palsy and cerebral vascular accident	data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	131	Effects of mirror therapy in upper limbs of young individuals with hemiparesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-25	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-27rmv3	<NULL>	"Dysfunctional diagnosis of hemiparesis with brachial predominance; 
Medical diagnosis of Cerebral Palsy or Cerebral Vascular Accident, of prenatal or perinatal etiology; 
Age between 15 and 25 years;
Normal cognitive function."	"Visual and/or hearing impairment;
Mental deficiency; 
Muscular contractions that unable the execution of the tests;
Muscle tone of affected upper limb equal to or greater than 3 in the Ashworth Scale; 
Botulinum toxin  injections and/or surgery during the previous 6 months;
Subjects who do not accomplished 25% or more of the intervention sessions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-58yq52	Acupuncture in Multiple Sclerosis	data analysis completed	Intervention	2012-04-16	<NULL>	<NULL>	132	Impact of electroacupuncture on quality of life for patients with Relapsing-Remitting Multiple Sclerosis under treatment with immunomodulators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Departamento de Clinica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP	Juan G. Quispe-Cabanillas	https://ensaiosclinicos.gov.br/rg/RBR-58yq52	<NULL>	Patients with a confirmed diagnosis of RRMS according to the revised 2005 McDonald criteria and under treatment with immunomodulatory drugs (interferon-beta and glatiramer acetate) were selected.	Those individuals who had previously received acupuncture treatment were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-5dmpkr	Effect of physical therapy in the diaphragm of the elderly on the function of the lungs	recruitment completed	Intervention	2012-05-10	<NULL>	<NULL>	133	Study of the transcutaneous electrical diaphragmatic muscle stimulation.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5dmpkr	<NULL>	"Male volunteers;
Aged between 67 and 79 years;
Not practicing physical exercises regularly."	"Elderly Smokers;
History of pulmonary disease, neuromuscular disorders and postural muscles that affect the respiratory or cardiovascular diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-63xvgf	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	data analysis completed	Intervention	2012-05-10	<NULL>	<NULL>	134	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade do Vale do Paraíba - UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-63xvgf	<NULL>	"Clinical diagnosis of fibromyalgia;
Age between 20 and 80 years;
Signing the consent form;"	Don´t have	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-268hqh	Effects of  pulmonary re-expansion maneuver on patients receiving mechanical ventilation	data analysis completed	Intervention	2012-05-01	<NULL>	<NULL>	135	Effects of Manual Chest Compression and Descompression Maneuver on Lung Volumes, Capnography and Pulse Oximetry in Patients Receiving Mechanical Ventilation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-21	Hospital e Maternidade Celso Pierro	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-268hqh	<NULL>	"Age greater than 18 years
Patients on mechanical ventilation
Ramsay sedation scale between 4 and 6 levels
Hemodynamic stability 
No osteoarticular lesions (rib fractures or unstable thorax)."	"Intracranial hypertension &gt; 30 mmHg
Pneumothorax 
Hemodynamic instability with use of high doses of vasoactive drugs, dopamine and dobutamine &gt; 5 µg/kg/min and noradrenalin &gt; 0.5 µg /kg/min"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-25tcrt	Effects of electrical stimulation and ventilatory muscle training in patients with kidney disease on hemodialysis	recruiting	Intervention	2012-05-01	<NULL>	<NULL>	136	Effects of functional electrical stimulation and inspiratory muscle training on quality of life and functional capacity of patients with end-stage renal disease on hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-10	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade da Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-25tcrt	<NULL>	Patients with ESRD undergoing hemodialysis more than 3 months; Urea clearance during hemodialysis (Kt / V) &gt; 1.2	Patients with recent stroke, disabling osteoarticular or musculoskeletal disease, uncontrolled hypertension (SBP &gt; 230mmHg and DBP &gt; 120 mmHg), heart failure class III or IV according to the NYHA or decompensated, uncontrolled diabetes (glicaemia &gt; 300 mg / dL), unstable angina, fever and / or infectious disease, acute respiratory failure; recent acute myocardial infarction (2 months), active smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-44xmsx	Effects of the ultrasound therapy on venous ulcer healing	not yet recruiting	Intervention	2012-05-07	<NULL>	<NULL>	137	Effects of ultrasonic waves application on morphometric parameters and metalloproteases gene expression in venous ulcers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-07	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-44xmsx	<NULL>	"Unhealed venous ulcer with at least eight weeks of duration
Ankle-brachial index equal or higher than 0,8
Without signs of venous ulcer infecction
Without previous diagnosis of connective tissue disease that may interfere in the healing process
Without contraindication for ultrasound use"	"Wound infecction
Exclusion by patient request"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6kvx74	Effect of drug therapy in the treatment of migraine	not yet recruiting	Observational	2012-04-26	<NULL>	<NULL>	138	Additional effect of physical therapy to drug treatment in reducing the intensity and frequency of migraine - a randomized controlled trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2011-11-01	Faculdade de Medicina de Ribeirão preto da Universidade de São Paulo	Departamento de Biomecânica Medicina e Reabilitação do Aparelho Locomotor.	https://ensaiosclinicos.gov.br/rg/RBR-6kvx74	<NULL>	Will be included 50 individuals with migraine, female, aged between 18 and 55. Will be considered only patients with at least two attacks and a maximum of 12 days of pain per month, with disease duration longer than one year, they are only in ambulatory treatment with amitriptyline up to 25 mg for at least 3 months.	Will be excluded women with diagnoses of other concurrent headache diagnosis of migraine, history of cervical trauma and face, with uncontrolled systemic diseases affecting the musculoskeletal system, peripheral nervous system diseases, which have physical therapy in the last one year specific to region or craniocervical posture and have some clinical contraindication to the use of amitriptyline as cardiac arrhythmias, glaucoma and epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-67zvt5	Homeopathic medicines as complementary treatment of cocaine dependence.	recruiting	Intervention	2012-05-01	<NULL>	<NULL>	139	Fifty-millesimal potencies of Opium and Erythroxylum coca as complementary treatment of cocaine dependence: pilot, randomized, placebo controlled, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-12	Universidade Federal de São Paulo	Centro de Referência de Álcool, Tabaco e Outras Drogas da Secretaria de Estado da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-67zvt5	<NULL>	"Patients between 18 and 65 years, who met DSM-IV TR criteria for cocaine dependence 
Capacity and willingness to give informed consent and to comply with study procedures
were also required."	Disabling clinical or psychiatric diseases that would hinder regular participation in the study; acupunture or homeopathic  treatment simultaneously to the study; simultaneous participation in another clinical trial; concomitant pregnancy; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-55t5v9	Treatment of severe stroke guided by parameters regarding brain protection and neurological recovery	not yet recruiting	Observational	2012-05-01	<NULL>	<NULL>	140	Multimodal monitoring, inflammation and neuroregeneration in subarchnoid hemorrhage	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55t5v9	<NULL>	Patients of 18 to 65 years of age; have been hospitalized at Clinical Hospital, University of São Paulo Medical School within the first 72 h after the first hemorrhage; presenting Hunt and Hess grade IV or V; presenting anterior circulation aneurysm.	Having undergone some neurosurgical procedure at another facility (e.g. placement of an external ventricular drain) before admission at Clinical Hospital, University of São Paulo Medical School; presenting severe systemic disease; presenting either a Glasgow coma scale score of 3 or pathological posture accompanied by bilateral mydriasis with fixed pupils; unavailable information regarding level of consciousness previously to sedation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-3jdm6d	Analysis of the cardiac frequency and oxygenation during sleep in patients with the Obstructive Sleep Apnea Syndrome	recruiting	Observational	2012-04-24	<NULL>	<NULL>	141	Study of autonomic cardiac behavior and oxygen saturation during sleep in patients with the Obstructive Sleep Apnea Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3jdm6d	<NULL>	"Individuals of both sexes;
Aged 18-80 years;
With suspicion diagnosis of obstructive sleep apnea;
Who underwent full polysomnography in sleep Institute of San Carlos;
Technical data could be analyzed;"	Patients who underwent polysomnography, but whose data are not technically acceptable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7mmp6k	Ocular surface evaluation in ocular hypertension or inicial glaucoma patients treated with drops.	data analysis completed	Intervention	2012-04-24	<NULL>	<NULL>	142	Ocular surface evaluation in patients treated with prostaglandin analogues or timolol maleate monotherapy compared to  patients treated with fixed combination of prostaglandin analogues and timolol maleate 0,5% monotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mmp6k	<NULL>	Glaucoma or ocular hypertension patients with no previous topical hypotensive treatment.	Previous ocular surgery, active ocular inflammation or clinically diagnosed dry eye.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7b5ycz	Evaluation of dressing for central venous catheter	recruiting	Intervention	2012-04-26	<NULL>	<NULL>	143	Evaluation of the effectiveness of the chlorhexidine antimicrobial dressing for central venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-17	Universidade Federal do Paraná	3M do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7b5ycz	<NULL>	"Over 18 years;
Hospitalization in the Intensive Care Unit (ICU) or Semi Intensive (CTSI) Adult;
In the first use of central venous catheter (CVC) for short stay less than 24 hours;
Signing the consent form;
No known sensitivity to materials of the dressings."	"Refusal by the patient or explained by the family to participate in the research;
By shaving blade at the site of catheter insertion prior to puncture;
Sweating or bleeding from the orifice of the catheter;
Temperature above 38 ° C during puncture of the catheter."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-9jjj2n	Impact of exercise in ovseweight nondialyis dependent chronic kidney disease patients.	recruiting	Intervention	2012-04-09	<NULL>	<NULL>	144	Home-based vs in center aerobic exercise: impact on functional capacity, nutritional status and cardiometabolic parameters in overweight nondialysis dependent chronic kidney disease patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal de São Paulo	Fundação Oswaldo Ramos	https://ensaiosclinicos.gov.br/rg/RBR-9jjj2n	<NULL>	"Sedentary individuals with chronic kidney disease stages 3 or 4 disease;
Both genders;
Age between 30 and 65 years;
Overweight (BMI&gt; 25 kg/m2;
With a negative stress test."	"Patients with chronic obstructive pulmonary disease, class IV heart failure, myocardial infarction within the last 6 months, decompensated hypertension (systolic blood pressure&gt; 180 mmHg or diastolic&gt; 110 mmHg in the last 6 months), uncontrolled cardiac arrhythmia, decompensated diabetes mellitus (glycated hemoglobin&gt; 8.0%), unstable angina, infectious processes in the last 3 weeks;
Use of erythropoietin or beta-blocker medication or with hemoglobin &lt;11g/L."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-4b45px	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	data analysis completed	Intervention	2012-04-10	<NULL>	<NULL>	145	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Centro de Pesquisa Fima Lifshitz	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4b45px	<NULL>	"Male children 2-30 months old
 Pre-classified with acute diarrhea and  dehydration."	"Only breastfeeding nutrition
 With severe malnutrition
 With clinical suspicious or documented signs and symptoms of chronic illness or systemic infection
 Not able to understand the nature of study and sign the inform consent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6z42q3	Evaluation of a type of therapy for the treatment of vaginal pain during intercourse.	recruiting	Intervention	2012-04-11	<NULL>	<NULL>	146	Electrical stimulation of the pelvic floor in the treatment of women with chronic vulvar pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-02	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6z42q3	<NULL>	"Women with vulvodynia symptons, for, at least 6 months
 Women with positive test for vulvodynia 
 Women willing to participate and to accept and sign voluntarily, the consent term"	"Women who use intrauterine device
 Pregnancy
 Women who use pacemakers
 Women who have some sort of metal implant in the region of the lumbar spine or hip
 Women who have neoplasic diseases
 Women with acute infectious process in the vulvar region
 Chronic Immunosuppression
 Deformity of the spine or pelvis
 Genital ulcer
 Women on medications that may cause mucositis (eg prolonged use of antibiotics, immunomodulators, chemotherapeutics)
 Women with systemic or acute allergic framework (localized)
 Women who are known to have chronic degenerative disease (eg Acquired immunodeficiency syndrome, renal transplant, lupus, tuberculosis)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6c2k3m	Evaluation of two types of implants installed in the jaw	recruiting	Intervention	2012-04-16	<NULL>	<NULL>	147	A comparative study of marginal bone variation around Titanium-13Zirconium and versus Titanium Grade IV.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c2k3m	<NULL>	"To sign voluntary informed consent for using his/her data;
At least 18 years-old; 
Posterior edentulous areas that needed at least 2 implants in the maxilla, or 2 implants in the mandible 
To have a posterior area to receive one narrow implant diameter at least 8 weeks to implant installation;
5 mm of ridge width and 8 mm of lengh; These implants had to receive one single-crown rehabilitation and to have a antagonist tooth
1 year of follow up."	"Presence of sistemic problems, ex. diabetes
Use of any drug that could affect bone metabolism (biphosphonates);
Tobacco abuse (&gt; 10 cigarettes/day);
Presence of immunocompromising conditions (HIV-positive, AIDS, or under therapy with immunosuppressive drugs);
Disability that interferes with the ability of a suitable cleaning;
History of radiotherapy of the head/neck region . 
Pregnancy or lactating;
Condition or circumstance that may lead patients to abandon the study;
Presence of untreated periodontitis;
Soft and/or hard tissues alterations;
Previous bone augmentation procedure in the same place to fixture installation; 
Presence of parafunctional habits;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6g8yz9	Treating lymphangioleiomyomatosis with doxycycline	data analysis completed	Intervention	2012-03-29	<NULL>	<NULL>	148	Effects of doxycycline on radiological and functional assessment and metalloproteinase blockage in patients with lymphangioleiomyomatosis	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2011-01-08	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6g8yz9	<NULL>	Patients with an established clinical-radiological or histopathological diagnosis of lymphangioleiomyomatosis	Patients submitted previously to lung transplant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7m3mnd	The melatonin analgesic effect in a human pain model	recruitment completed	Intervention	2012-03-31	<NULL>	<NULL>	149	The melatonin analgesic effect in a human nociceptive and inflammatory pain model.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2011-05-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7m3mnd	<NULL>	"Healthy volunteers;
Age between 18 and 45 years;"	"Current acute or chronic pain conditions;
Pregnancy;
Use of analgesics within 1 week;
Use of any psychoative medications;
Any chronic cardiac, rheumatologic, pulmonary, infectious or neurologic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-795k8m	Oral splint and counselling for the treatment of chronic facial pain	not yet recruiting	Intervention	2012-03-31	<NULL>	<NULL>	150	The efficacy of occlusal stabilization appliance associated to counselling in the management of myofascial pain chronic and in the improvement of the quality of life of patients with temporomandibular disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-05	Universidade Federal de Juiz de Fora	Patrícia Rocha Coelho	https://ensaiosclinicos.gov.br/rg/RBR-795k8m	<NULL>	"All subjects participated in this study volunteers by signing the consent form. Inclusion criteria are as follows:
female subjects;
aged 20 to 55 years;
irrespective of race, social status or religion;
presence of pain intensity of at least moderate (at least 4.0 on VAS), shown in the first clinical assessment;
diagnosis of myofascial pain persisting for a minimum period of six months."	"history of psychiatric disorders or treatment for neurological or psychological disorders;
volunteers with severe intellectual or physical disability that would hinder the collection of data;
history of systemic diseases that generate joint symptoms, muscle or rheumatologic, such as rheumatoid arthritis and fibromyalgia;
pain attributed to a well-defined local cause, such as pulpitis, trigeminal neuralgia and cancer pain;
attributable to migraine pain or infection;
report of any previous treatment for TMD;
treatment with drugs affecting the central nervous system (muscle relaxants, anticonvulsants, opioids, and antidepressants) and treatment with analgesics and anti-inflammatory drugs, with or without prescription, concomitant therapies to be instituted in this research;
report of facial trauma as a possible etiology of TMD;
subject denture wearers an upper or lower;
volunteers aged under 20 or over 55 years;
male individuals."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-5d877q	Cardiac responses during rehabilitation in patients undergoing cardiac surgery	data analysis completed	Intervention	2012-04-04	<NULL>	<NULL>	151	Study of cardiac autonomic modulation and pulmonary function in patients undergoing coronary artery bypass grafting and physiotherapy program: phase I of cardiac rehabilitation.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Universidade Federal de São Carlos	Irmandade Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-5d877q	<NULL>	"Coronary artery disease (CAD) 
Elective coronary artery bypass surgery (CABG) carried out with cardiopulmonary bypass (CPB)."	"Patients who had undergone coronary artery bypass surgery (CABG) without cardiopulmonar bypass (CPB) or concomitant surgery;
History of myocardial infarction &lt; 6 months before CABG, severely depressed LVF (left ventricular ejection fraction &lt;30%), acute significant arrhythmias, coexisting chronic obstructive pulmonary disease (COPD), autonomic neuropathy, severe non-cardiac disease; 
Inability or refuse to perform the proposed protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-9x5jfn	Effects of manipulation of foot muscles in people who have acquired brain injury	other	Intervention	2012-03-13	<NULL>	<NULL>	152	Manipulation of intrinsic muscles of the foot in people with acquired brain injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-09	Centro Universitário de Rio Preto - UNIRP	Centro Universitário de Rio Preto - UNIRP	https://ensaiosclinicos.gov.br/rg/RBR-9x5jfn	<NULL>	"Patients with acquired brain injury;
Ability to stay in standing position without assistance of the upper limbs."	"Do not assume standing position; 
Age below 18 years; 
Owning a pathology that prevents the collection of results."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-4qzm6s	Physical Exercises, neuropsychiatric disturbances and Activity Daily Living performance on women with Alzheimer´s Disease.	data analysis completed	Intervention	2012-03-04	<NULL>	<NULL>	153	A controlled clinical trial on the effects of physical exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer’s disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	São Paulo State University	Departamento de Educação Física - Instituto de Biociencias da UNESP/RC	https://ensaiosclinicos.gov.br/rg/RBR-4qzm6s	<NULL>	Women over 60 years with clinical diagnosis of probable Alzheimer&apos;s disease in mild to moderate stages of the disease, residents in the community with independent locomotion.	Elderly males, elderly without cognitive impairment, with other neurological conditions, limited mobility to preclude the exercise protocol and physical prior participation in other exercise programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-4z9wdg	Comparison among two drugs commonly used in the prevention and treatment of thrombosis, to prevent thromboembolism after total cavopulmonary operation.	recruitment completed	Intervention	2012-03-07	<NULL>	<NULL>	154	A comparative study of oral anticoagulants and antiplatelet prophylaxis of thrombosis and thromboembolic events in the Fontan operation using extracardiac conduit.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-31	Hospital do Coração da Associação do Sanatório Sirio	Hospital do Coração da Associação do Sanatório Sirio	https://ensaiosclinicos.gov.br/rg/RBR-4z9wdg	<NULL>	"Scheduling total cavopulmonary operation according to the clinical criteria for surgery.
 Parents or guardians agree to the inclusion in the study."	Patients with contraindications to receive any of the medications (sodium warfarin or aspirin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-969prp	Effect of a Pilates exercise program on flexibility, muscle performance and balance of elderly women.	recruiting	Intervention	2012-03-07	<NULL>	<NULL>	155	Effect of an exercise program based on the principles of the Pilates method in flexibility, muscle performance and balance of elderly women: a randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-31	Universidade Federal do Rio Grande do Norte (UFRN)	Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-969prp	<NULL>	Female; aged 65 to 80 years; absence of neurological and muscle - skeletal disease that preventing the holding of the exercises, as well as the use of a wheelchair for mobility; cognitive status compatible with schooling assessed by the Mini Mental State Examination (MMSE).	Refusal to participate in the survey; pain complaints during the course of training; unexcused absence and without replacement in 10% of training provided.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-2k3kbq	Comparison of the effectiveness of the use of pads in adult patients admitted to the Intensive Care Unit	not yet recruiting	Intervention	2012-03-07	<NULL>	<NULL>	156	Comparison of the effectiveness of the use of pads in adult patients with diagnoses of hyperthermia admitted to the Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Escola de Enfermagem Universidade Federal de Minas Gerais	Hospital Municipal Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-2k3kbq	<NULL>	"For inclusion of patients in this study will be established the following criteria: 
be over 18 years;
body temperature 38.3 ° C;
to consent to participate in the survey or have authorized their participation by signing the Statement of responsibility Consent"	"Exclusion criteria are: 
patient or guardian does not agree to sign the Instrument of Consent;
patients with severe heart disease, traumatic brain injury, malignant hyperthermia, pregnant women, which has a history of adverse reactions following the use of physical methods (hot or cold) in the reduction of body temperature and do not tolerate treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-83mmq5	Effect of mirror therapy associated with functional tasks in arm function after stroke	recruiting	Intervention	2011-07-07	<NULL>	<NULL>	157	Effect of mirror therapy associated with functional tasks in arm function after stroke: a randomised clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-83mmq5	<NULL>	This will include individuals who suffered Stroke proven by CT scan or MRI for at least 6 months (chronic phase). Those with motor recovery level &gt; 30 (mild or moderate impairment) in the upper extremity section of the Fugl-Meyer motor assessment, scores on the modified Ashworth scale 2 or less for muscle groups evaluated (horizontal shoulder adductors, elbow flexors and wrist and finger flexors) and those able accomplish a task of handling rough (reach and grab a cylindrical object).	Will be excluded individuals with other neurological diseases, orthopedic problems in the upper limbs that interfere with the function of these, significant visual impairment not correctable, aphasia or difficulty to understanding simple tasks (eg reach and grasp a bottle); visual hemineglect verified through the Bells Test; members of other research or therapy involving the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-7cb9yc	Effects of two physiotherapy approaches in patients with low back pain	recruiting	Intervention	2011-11-06	<NULL>	<NULL>	158	Immediate effects of specific or inespecific spinal manipulation in patients with chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-07	Universidade Cidade de São Paulo	Bandagens Plus	https://ensaiosclinicos.gov.br/rg/RBR-7cb9yc	<NULL>	We will include patients who will be seeking care for chronic low back pain as well as patients with chronic low back pain from the community with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for manual therapy will be excluded (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-34v9px	Analysis of the effect of vibration in patients with stroke	recruitment completed	Intervention	2012-02-16	<NULL>	<NULL>	159	Analysis of the effects of low frequency vibration in patients affected by stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-03	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-34v9px	<NULL>	"Hemiparesis due to stroke with more than 3 months of injury; 
Age over 30 years; 
Both sexes; 
without distinction of race; color and socioeconomic; 
Level with mental competence assessed by the mini-mental examination and reduction of motor function assessed by rating scale Fugl-Meyer."	"Younger than 30 years; 
Acute cerebral vascular accident; 
low level of mental competence; 
Using pacemaker; 
Uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-2z9xyb	Use of citrate content dialysate in patients on hemodialysis	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	160	Effects of the use of citrate content dialysate on the extracorporeal anticoagulation in maintenance hemodialysis	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2011-07-01	Divisão de Nefrologia da Faculdade de Medicina da Universidade Federal Fluminense	CDR- Clínica de Doenças Renais	https://ensaiosclinicos.gov.br/rg/RBR-2z9xyb	<NULL>	Patients older than 18 years of age, both genders, on maintenance hemodialysis, without major comorbidities.	"Prescription of hemodialysis shorter than 3h 30 min.
Use of oral anticoagulant.
Use of temporary double lumen catheter.
Awating for living donor kidney transplant.
Refuse to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-3hkqg9	Reduction in blood pressure after cycle ergometer exercise and its physiological regulators: influence of time and association with hormone variation.	not yet recruiting	Intervention	2012-02-13	<NULL>	<NULL>	161	Post-Aerobic Exercise Hypotension and its Hemodynamic and Neural Mechanisms in Pre-Hypertensives: influence of time and association with circadian endocrine regulation.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratóio de Rins e Hormônios da Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3hkqg9	<NULL>	"Men
Aged between 20 and 40 years 
Systolic blood pressure between 120-139 mmHg and/or diastolic 80-89 mmHg
No diabetes
Sedentary or insufficiently active (did not perform physical activity more than twice a week)
Non smokers
Do not take any medicine that affects the cardiovascular system"	"Body Mass Index of equal to or greater than 30kg/m2
Subjects with cardiac diseases (previous diganosis or elatered rest or exercise ECG)
Individuals that are experiencing poor quality sleep (score greater than 5 at Pitsburg Sleep Quality Index)
- Not having chronotype intermediary, or be morning or evening"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-7ynkx6	Study for comparative evaluation of efficacy and safety of nitrendipino (Caltren) versus nifedipino (Adalat retard) in the treatment of mild arteial hypertension.	other	Intervention	2012-02-13	<NULL>	<NULL>	162	Open label, prospective, parallel, multicenter and randomized study for comparative evaluation of efficacy and safety of nitrendipino (Caltren) versus nifedipino (Adalat retard) in the treatment of arteial hypertension stage 1.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2012-06-01	Libbs Farmaceutica Ltda	Libbs Farmaceutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7ynkx6	<NULL>	"Adult patients over 18 year-old from both genders;

ICF signed by the participant;

Patients diagnosed with hypertension stage 1, according to the definitions and orientations publicized in the VI Brazilian Arterial Hypertension Guidelines."	"fertile women, independently of the use of contraceptive methods;

known hypersensitivity to study medications;

non-adherence to the placebo treatment during the run-in period;

laboratory exams collected in the screening visit considered clinically significant by the investigator;

ECG performed during the screening visit showing ventricular arrhythmia, atrium-ventricular block of 2nd or 3rd degree, arrhythmia, tachycardia, bradycardia, or any other alteration considered clinically significant by the investigator;

Angina pectoris CCS class III or IV;

Decompensate angina pectoris NYHA class II or IV;

BMI over 35 kg/m2;

moderate or advanced hepatic insufficiency;

Severe or decompensate kidney insufficiency, characterized by creatinine clearance lower than 30 mL/min/1,73 m2 of corporal surface or dialyses required;

ongoing severe conditions, even if controlled by therapy: gastrointestinal, immunological, cardiovascular or cancer;

presence or history of significant edema of lower limbs (++/4+ or more);

myocardial infarction, myocardial revascularization or coronary angioplasty in the last 6 months or myocardial revascularization scheduled for the next 6 months;

significant or decompensate cardiac valvulopathy;

stroke or transient ischemic attack in the last 12 months or carotid revascularization scheduled for the next 6 months;

Uncontrolled diabetes (HbA1C over 9%);

history of angioneurotic edema;

any relevant disease that by investigator judgment may interfere in the study objectives or patients’ risks;

psychiatric disease that prevent the patient to participate in the study or cognitive disturbs (demential syndrome of any origin)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5f6qjg	Study of IMC-1121B (ramucirumab) with Best Supportive Care in patients with gastric cancer and adenocarcinoma	recruitment completed	Intervention	2013-01-02	<NULL>	<NULL>	163	A Phase 3, Randomized, Double-blinded Study of IMC-1121B and Best Supportive Care (BSC) Versus Placebo and BSC in the Treatment of Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Following Disease Progression on First-line Platinum- or Fluoropyrimidine-Containing Combination Therapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-24	ImClone Systems Incorporated	Quintiles Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5f6qjg	<NULL>	Histologically or cytologically confirmed gastric carcinoma, including gastric adenocarcinoma or Gastroesophageal Junction (GEJ) adenocarcinoma; metastatic disease or locally recurrent; unresectable disease with measurable lymph node metastases; measurable disease and/or evaluable disease. ; experienced disease progression during or within 4 months after the last dose of first-line therapy for metastatic disease, or during or within 6 months after the last dose of adjuvant therapy; disease not amenable to potentially curative resection; patient is over 18 years old; there is no maximum age for enrollment in the study; patient has a life expectancy of 12 or more weeks; patient resolution to Grade = 1 (or to Grade = 2 in the case of neuropathy) by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), Version 4.02, of all significant toxic effects of prior chemotherapy, surgery, radiotherapy, or hormonal therapy (with the exception of alopecia); Eastern Cooperative Oncology Group Performance Status score of 0-1; adequate hepatic function; adequate renal function; urinary protein is = 1+ on dipstick or routine urinalysis; adequate hematologic function; adequate coagulation function. ; if the patient has received prior anthracycline therapy as part of his or her first-line regimen, the patient is able to engage in ordinary physical activity without significant fatigue or dyspnea; patient, if sexually active, must be postmenopausal, surgically sterile, or using effective contraception (hormonal or barrier methods); female patients of childbearing potential must have a negative serum pregnancy test within 7 days prior to randomization; able to provide informed written consent and is amenable to compliance with protocol schedules and testing.	Brain or leptomeningeal metastases. Experienced any Grade 3-4 gastrointestinal bleeding within 3 months prior to randomization; experienced any arterial thromboembolic events within 6 months prior to randomization; ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, symptomatic or poorly controlled cardiac arrhythmia, uncontrolled thrombotic or hemorrhagic disorder, or any other serious uncontrolled medical disorders in the opinion of the investigator; ongoing or active psychiatric illness or social situation that would limit compliance with study requirements; uncontrolled or poorly-controlled hypertension; patient has a serious or nonhealing wound, ulcer, or bone fracture. Received chemotherapy, radiotherapy, immunotherapy, or targeted therapy for gastric cancer within 2 weeks prior to randomization; received any investigational therapy within 1 year prior to randomization; undergone major surgery within 28 days prior to randomization, or subcutaneous venous access device placement within 7 days prior to randomization; received prior therapy with an agent that directly inhibits VEGF or VEGFR-2 activity, or any antiangiogenic agent. Receiving chronic antiplatelet therapy; known allergy to any of the treatment components; pregnant or lactating; known to be positive for infection with the human immunodeficiency virus; known alcohol or drug dependency; concurrent active malignancy other than adequately-treated nonmelanomatous skin cancer, other noninvasive carcinoma, or in situ neoplasm; patient with previous history of malignancy is eligible, provided that he/she has been free of disease for &gt; 3 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-237wbg	Usefulness of Complete Blood Count and Ferritin Measurement in the Anemia Diagnosis in Pregnancy	recruiting	Intervention	2013-01-03	<NULL>	<NULL>	164	Accuracy of Erythrocyte Indices and Serum Ferritin on Diagnosis of Iron-Deficiency Anemia in Pregnant Women: A Phase III Validation Study of Diagnostic Tests	<NULL>	3, n/a, open	3	<NULL>	<NULL>	<NULL>	2011-08-10	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-237wbg	<NULL>	Hemoglobin concentration at least 0.7 and below 11.0 g/dL. Gestational age between 12 and 32 weeks of pregnancy. Low-risk pregnancy.	Hipersensibility or intolerability to ferros sulfate. Mental disease that precludes to understand the intervention. Unknowing the gestacional age. Another cause of anemia: sickel cell disease, talassemia, spherocytosis, autoimmune hemolytic anemia, leukemias,  anemia of crônic disease. Sistemic infeccious diseases: human immunedeficiency virus, siphilis, urinary infeccion, leucocytosis. Tobacco, alcohol or other drugs use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9wz5fc	Effect of Lifestyle Modification on the Risk Factors for Heart Disease	recruiting	Intervention	2013-01-04	<NULL>	<NULL>	165	Effect of Different Lifestyle Interventions on Metabolic Syndrome: Physical, Metabolic and Behavioral Aspects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-10	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9wz5fc	<NULL>	Men and women between 30 and 59 years of age with an abdominal circumference higher than 88 cm for women and higher than 102 cm for men and two (02) or more of the following findings:Blood pressure: systolic equal or higher than 130 mmHg and diastolic equal or higher than 85 mmHg; fasting glucose: equal or higher than  100 mg/dl; triglycerides:equal or higher than  150 mg/dl; HDL cholesterol less than 40 mg/dl for men and less than50 mg/dl for women.	Absolute contraindication to physical activity for musculoskeletal problems, neurological, vascular events (intermittent claudication), lung and heart; Presence of a diagnosis of severe psychiatric disorders and / or presence of significant cognitive impairment assessed by the team through the Mini-Mental State Examination; Difficult to contact and inability to return and follow-up, not available to participate in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-63gdgg	Mobilization of the mouth of the joint in subjects with and without changes in the joint of the mouth	recruitment completed	Intervention	2012-02-13	<NULL>	<NULL>	166	The influence of mobilization of TMJ on the center of pressure in individuals with and without TMD: A clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-04-04	Universidade Nove de Julho	Universidade Nove de  Julho	https://ensaiosclinicos.gov.br/rg/RBR-63gdgg	<NULL>	The volunteers should be aged between 20 and 40 years. Both genders and have full dentition. TMD Group: Display TMD - Mandibular deviation or deflection. Control Group: Not having TMD.	Present crossbite. Present overshot or undershot jaw. Use any type of dental prosthesis. Be in orthodontic treatment or physical therapy. Providing orthopedic and neurological disorders that interfere with the body balance, that information will be reported by the individual and if necessary the presentation of examinations. Use of arch supports. Had blood pressure (BP) high or low. Provide auditory, vestibular, which may interfere with the balance information to be reported by the individual and if necessary the presentation of examinations. Use of medication that may interfere with the balance. Be younger than 20 years and greater than 40 years. Being overweight analyzed with the BMI (Body Mass Index)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9x8ssz	Influence of two interventions for temporomandibular disorders on the eletric activity of the masticatory muscles and balance.	recruiting	Intervention	2012-03-07	<NULL>	<NULL>	167	Influence of the inespecifc mobilization and the massotherapy on the eletromiographic sign of masticatory muscles and the static balance in individuals with temporomandibular disorders. Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9x8ssz	<NULL>	Age: 18 to 50 years old. Diagnosed with temporomandibular joint disorder. Complete Dentition (except for the 3rd molars).	Dental protesis. Open and/or Crossbite. Mandibular prognatism or retrognatism. Neurological Disturbance. In Physioterapic or odontologic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8n4hg2	Effects of Interferential Therapy on the Mechanisms of Pain in Chronic Low Back Pain Without a Specific Cause	recruiting	Intervention	2013-01-05	<NULL>	<NULL>	168	Effects of Carrier Frequency of Interferential Current on Modulation of Pain and Central Hypersensitivity in Patients with Nonspecific Chronic Low Back Pain: Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Cidade de São Paulo	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n4hg2	<NULL>	Patients presenting nonspecific low back pain for at least 3 months and with at least 3 of pain intensity in verbal numerical pain scale reported according to how they felt in the last 7 days, aged between 18 and 80 years, both genders	Patients with serious spinal diseases, such as fractures, tumors and inflammatory diseases such as ankylosing spondylitis, spinal root conditions confirmed by neurological tests (spondylolisthesis and disc herniation with neurological, narrowing spinal canal and others). Severe cardiorespiratory disease. Neurologial diseases. Pregnancy. Infection in the site of the current application. Cancer. Cardiac pacemaker. Skin lesions at the site of the current application. Alterations in sensibility and allergy in the region of electrodes placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-6hp5h9	Effect of Balance Training in Older Adults	recruiting	Intervention	2013-01-15	<NULL>	<NULL>	169	Effect of a Perturbation-based Balance Training Program on the Reactive Neuromuscular Control in Older Adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-15	Universidade Estadual do Centro-Oeste	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6hp5h9	<NULL>	Healthy older, between 65 and 80 years, living in the community.	Presence of cardiovascular, neurological or vestibular diseases. Presence of musculoskeletal problems that interferes with static or dynamic balance. Peripheral neuropathies. Use of medication for central nervous system. Mini-mental State Examination (MMSE) score less than 19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-3q3q98	Weight Training, Apathy and Motor Function in Alzheimer&apos;s Disease	data analysis completed	Intervention	2013-02-22	<NULL>	<NULL>	170	Weight Training, Apathy Syndrome and Motor Function in Patients With Alzheimer&apos;s Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-15	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-3q3q98	<NULL>	Patients diagnosed with Alzheimer´s disease both genders aged 60 years and over. Elderly people with mild and moderate levels of  dementia. Patients and their caregivers that were consistent with the procedures of the  study and who signed the Instrument of Consent. Patients ambulating	Patients with other neuropsychiatric conditions or clinical comorbidities that interfere with the apathetic condition, provided in front or cognitive motor procedures to be developed. Patients who had contraindications to physical activity. Patients with bone-mioarticulares problems, serious heart disease or amputations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-7wm8mz	Response Oxygenation in Premature Newborns with use of Thoracic Elastic Band Positions in Two Body	data analysis completed	Intervention	2013-02-28	<NULL>	<NULL>	171	Effect of Posture Positioning Front Support from Gradil Costal Premature Newborn	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-04-04	Faculdade Medicina Ribeirão Preto - USP	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7wm8mz	<NULL>	Newborn premature birth with a minimum weight of 1200g and maximum of 2500g the gestational age of 36 weeks maximum, without ventilatory pressure and without supplemental oxygen, without infection and with good general	Newborns classified as extremely premature, history of apnea, heart disease, congenital malformations, severe anoxia, hydrocephalus, post-abdominal surgery, neonatal infection, term newborns, ranked small for gestational age, use of ventilation system positive pressure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9kdzdv	Insulin Secretion in Healthy, in Obese and in Obese Type 2 Diabetic Patients Undergoing Bariatric Surgery	recruitment completed	Intervention	2013-03-01	<NULL>	<NULL>	172	Insulin Secretory Capacity in Healthy, in Obese, and in Obese Type 2 Diabetic Patients Undergoing Bariatric Surgery Through the Hyperglycemic Clamp	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9kdzdv	<NULL>	Female, older than 20 years, being in premenopausal period, type 2 diabetic patient using only oral anti-diabetic medication or no medication for diabetes, weight variation less than 5% in the last 3 months; capacity to understand the procedures of the study and voluntarily agree to participate in the study by signing the consent form.	Patients taking insulin or drugs with effects on insulin secretion; BMI greater than or equal to 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; alteration of renal function, a recent history of cancer, use of oral corticosteroids or injected by more than 14 consecutive days in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-7x429s	Effects of Cardiac Rehabilitation and Respiratory Capacity and Physical Behavior of Oxygen Consumption in Cardiac Patients	recruiting	Intervention	2013-03-05	<NULL>	<NULL>	173	Effects of Cardiopulmonary Rehabilitation on Exercise Tolerance Time (Tlim) and Oxygen Uptake Kinetics in Ischemic Heart Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Hospital do Coração - HCor - Instituto de Ensino e Pesquisa (I.E.P.)	Comitê de Ética em Pesquisa da  Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7x429s	<NULL>	Patients with ischemic cardiomyopathy with an ejection fraction of the left ventricle than or equal to 35% of both sexes. The minimum age of 18 years and maximum 90 years.	Functional limitations not related to the cardiovascular system. Such as disabling lung diseases and tumors of advanced degree.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-3p7577	Comparison of Anti Pneumococcal Vaccinal Response in HIV-positive Adults	data analysis completed	Intervention	2013-03-13	<NULL>	<NULL>	174	Comparison of Response to Vaccination with Three Different Schemes Pneumococcal Vaccine in Adults Infected by Human Immunodeficiency Virus	<NULL>	1, single-arm-study, double-blind	1	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-3p7577	<NULL>	All individuals aged 18-60 years with HIV infection documented by enzyme-linked immunosorbent assay (ELISA) and Western-Blot testing, and with T-CD4 count above 200 cells/mm3 in two different occasions in the past six months were eligible. Were included in trial individuals who demonstrated understanding and signed consent form.	Exclusion criteria included: any acute febrile illness at the moment of vaccination, active AIDS-defining clinical condition, previous immunization with any of the pneumococcal vaccines, any systemic malignancy neoplasm, use of immunoglobulin within the last three months, current pregnancy, antecedent of allergy to any of the pneumococcal vaccine components.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-6xsb5h	The Effect of Laser Therapy After Surgery	recruiting	Intervention	2013-03-19	<NULL>	<NULL>	175	The Effect of Low Level Laser Therapy in the Modulation of the Inflammatory Process After Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6xsb5h	<NULL>	Patients who need to perform removal of impacted third molars and to accept part of the study as informed consent and informed.	Systemic diseases, chronic pain or neurological and psychiatric disorders. Being a smoker. Being using anti-inflammatories, analgesics or bisphosphonates in the past 15 days have provided the framework of pericoronitis in the last month. Being pregnant. Being  breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-4qpj2r	Effect of Human Ration on Weight Loss and Bone Health in Overweight Women	Data analysis completed	Intervention	2013-04-02	<NULL>	<NULL>	176	Effect of Human Ration in Weight Loss and in Bone Health in Overweight Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-4qpj2r	<NULL>	Female gender. IMC higher than 25 and less than 34.9 kg/m2 and age between 24 and 45 years.	Pregnant or breastfeeding women. Menopausal women or who underwent removal of the uterus. Which used anti-inflammatories. Who presented intolerance or allergy to any ingredient in the product. Which drink´s alcohol or smokes. Who were using the drug for inhibiting appetite. Antidepressants or whatever to interfere in bone mineral metabolism (bisphosphonates, anabolic steroids, calcitonin, fluoride, hormone replacement therapy, androgens, calcium, vitamin D, thiazide diuretics, and statins). Women with a history of conditions or diseases associated with changes in bone mass such as kidney disease (cholelithiasis, chronic renal failure), gastrointestinal disease (celiac disease, chronic liver disease, malabsorption syndrome, gastrectomy or colectomy). History of endocrine disease (hyperparathyroidism, hyperthyroidism or hypothyroidism). Fractures in the last six months. Which had shown restraint for more than two months and showed fluctuations in body weight greater than 5% in the two months before recruitment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8f57kr	Impact of a Program of Subaquatic Therapeutic Exercises in Elderly Women with Knee Osteoarthritis	Data analysis completed	Intervention	2013-04-15	<NULL>	<NULL>	177	Impact of a Structured Program of Subaquatic Therapeutic Exercises in Elderly Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-30	Universidade Federal  de Minas Gerais	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8f57kr	<NULL>	Elderly aged over 65 years. Diagnosis (clinical and radiological)of knee osteoarthritis. Not undergoing surgery. No history of recent trauma on the knee.  Accessory independent for locomotion. Not subjected to physical therapy in the last three months. With conditions to perform clinical and cognitive activity in the pool. Continents and without contagious dermatological diseases.	Absence of a clinical and radiological diagnosis of knee osteoarthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-5hsvfr	The Impact of the Substitution of Convencional Salt for a Salt With Less Sodium on the Blood Pressure of Patients With High Blood Pressure	Data analysis completed	Intervention	2013-04-16	<NULL>	<NULL>	178	The Impact of the Substitution of Convencional Salt for &quot;Light Salt&quot; on the Blood Pressure of Hypertensive Patients	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-14	Linea Sucralose	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5hsvfr	<NULL>	Patients which are regularly monitored by the League of Hypertension of the UFG&apos;s Hospital, residents of the metropolitan area of Goiânia, with stable dose of antihypertensive medication for at least 30 days and with uncontrolled hypertension (BP 140 x 90 at last visit).	Patients with acute or subacute (up to 3 months before the start of the project). Unstable chronic diseases (diabetes mellitus, heart failure, liver disease, chronic renal failure, lung disease or other that, according to the researchers, could compromise the follow-up protocol). Patients, one or more days a week, eat lunch and dinner at places where they can not perform the preparation of meals using only salt supplied by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9b5dh7	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy	Recruiting	Intervention	2013-04-18	<NULL>	<NULL>	179	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy: Clinical Trial Randomized Controlled, Double Blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Node de Julho	Centro de Neurocirurgia Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-9b5dh7	<NULL>	Children with cerebral palsy. Age between 4 and 12 years. Absence of cognitive or visual impairment that could compromise the performance of the tasks. Levels I, II and III of the Gross Motor Functional. Classification System (GMFCS). Functional ambulation for at least 12 months.	Orthopedic surgical procedures or neuromuscular block in the 12 months prior to the training sessions. Presence of orthopedic deformities with surgical indications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-3t3yck	The Effects of Elastic Bandagens in People With Knee Arthrosis	Recruitment completed	Intervention	2013-04-18	<NULL>	<NULL>	180	The Efefcts of Elastic Bandages on Gait Biomechancs, Muscular Performance, Pain, and Physical Function in Individuals with Knee Osteoartritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3t3yck	<NULL>	Women with mild and moderate clinical and radiographic diagnoses of bilateral knee osteoarthritis (OA), who are able to walk independently, have no cognivite deficits, have a mody mass index below 30kg/m2, and not be submitted to surgery in any joint of the lower limbs.	Absence of pain on the day of the experiment, in addition to those who have full movement of a joint (ADM) active, less than 90 degrees of flexion at the knee and/or hip, and skin fragility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-9k7s9j	Changes in Heart Rate and Benefits of an  Exercise Training Carried Out During Hemodialysis in Intensive Care Unit Patients (ICU)	Not yet recruiting	Intervention	2013-04-19	<NULL>	<NULL>	181	Hemodynamic Effects of Physical Activity in Critically Ill Patients During Hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k7s9j	<NULL>	Hemodynamical stability, hemoglobin &gt; 6 g/dl and lower limb problems that precluded exercise (for example leg bone tumor, deep vein thrombosis).	Catheter positioned in arterial femoral site.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-4rjwrx	Training and Manual Behavior in Premature Infants	Recruiting	Intervention	2013-04-25	<NULL>	<NULL>	182	Effects of Specific Training on the Ability of Reaching in Preterm Infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-20	Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-4rjwrx	<NULL>	Infants born below 37 weeks considered low risk for brain injury, with Apgar Scores of greater than 7, without major pre- and perinatal complications, and at maternal care.	Infants considered high risk, whose medical records report the occurrence of: anoxia, signs of neurological impairment (eg, hypoxic-ischemic encephalopathy grades I, II and III, intracranial hemorrhage, and neonatal seizures), congenital malformations (eg, anencephaly, spina bifida, acondroplasias, microencephaly), genetic syndromes (eg, Down syndrome and chromosomal deletion), sensory changes (visual and auditory), difficulties cardiorespiratory, orthopedic impairment and / or musculoskeletal,  hyperbilirubinemia. For the selection or non-inclusion of infants in the studies according to the risk factors described above, the medical records will be taken as a reference to obtain such information, as well as prompted the collaboration of neonatologists and pediatricians selection of sites for confirmations and questions to resolve.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-7sw5hf	Laser Acupuncture to Temporomandibular Disorder Treatment	Recruitment completed	Intervention	2011-02-02	<NULL>	<NULL>	183	Adjuvant Laser Acupuncture to Occlusal Splint Therapy: A Controlled Trial in Temporomandibular Disorders Patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-01	Luciano Ambrosio Ferreira	Marcos Vinicius Queiroz de Paula	https://ensaiosclinicos.gov.br/rg/RBR-7sw5hf	<NULL>	All subjects participated in this study volunteers by signing the consent. Female subjects. Aged between 20 and 40. Irrespective of race, creed or social level. Presence of a diagnosis of myofascial pain and arthralgia orofacial chronic, persisting for a minimum period of six months. Minimum intensity of muscle and joint pain of 4.0 points, measured in the Visual Analog Scale (VAS) during the first evaluation.	Subjects with evidence of muscle diseases, rheumatic and joint systemic origin, such as fibromyalgia and rheumatoid arthritis. Presence of fungal skin changes, hyperplastic, erythematous keloid or continuity in areas related to acupuncture points. Medical, pharmacological, psychological or physical therapy for temporomandibular disorder (TMD), concomitant therapies introduced in this study. Pregnants, the possible influence of intrauterine contraction and movement promoted by some acupuncture points such as LI4. Report or finding of facial trauma as a possible etiology of temporomandibular disorder. Individuals who have undergone prior treatment with neuromuscular relaxing plate, acupuncture or laser therapy for temporomandibular disorder. Subject denture wearers an upper or lower. Individuals with intellectual disability or impairment that would hinder the collection of data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-4z7cnh	Facial Edema Reduction by Manual Lymphatic Drainage at Postoperative Alveolar Bone Grafting	Recruitment completed	Intervention	2011-04-11	<NULL>	<NULL>	184	Randomized Open Controlled Parallel Trial on The Facial Edema Reduction Following Alveolar Bone Grafting by Manual Lymphatic Drainage	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2010-01-01	Hospital de Reabilitação de Anomalias Craniofaciais/ USP	Hospital de Reabilitação de Anomalias Craniofaciais/ USP	https://ensaiosclinicos.gov.br/rg/RBR-4z7cnh	<NULL>	Cleft lip and palate.	Hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-7nq8m7	Steroid Therapy for Autistic Children	Recruitment completed	Intervention	2011-04-12	<NULL>	<NULL>	185	Double-blind, Randomized, Placebo-Controlled Clinical Trial of Corticosteroids for the Autistic Spectrum Disorder	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-05-01	HUAP	HUAP	https://ensaiosclinicos.gov.br/rg/RBR-7nq8m7	<NULL>	Male gender. Age range, 3-7 years. Autistic spectrum disorder diagnosed according to the criteria at the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition-Text Revision (DSM-IV-TR). The subject&apos;s parents should read and sign the informed consent form, authorizing the researchers to recruit their child and to prescribe prednisolone.	Diagnosis of epilepsy. Diagnosis of a neurodegenerative disease. Diagnosis of cerebral malformations. Past history of meningitis or encephalitis. Diagnosis of a mass lesion in the central nervous system. Diagnosis of any other neurologic disorder. Gestational history suggestive of fetal or perinatal distress. Patient dos not fully meet the diagnostic criteria of autism. Patient&apos;s parents or caretakers did not sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-77q7t3	Evaluation of a New Product to Treatment of Malaria in Brazil	Recruitment completed	Intervention	2011-06-10	<NULL>	<NULL>	186	Study of Efficacy and Safety of a New Co-blister Packs of Chloroquine and Primaquine for Malaria Treatment of Uncomplicated Plasmodium Vivax in Brasil	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2011-07-01	Farmanguinhos-FIOCRUZ	OPAS	https://ensaiosclinicos.gov.br/rg/RBR-77q7t3	<NULL>	Age greather than or equal to 18 years and less than 65 years old or weight greather than 50 pounds a less than 80 pounds. Mono infection with P. Vivax confirmed by microscopy. Asexual parasite count greater than 250/ml. Axillary temperature greater than 37.5 ° C or history of fever 48 hours before the enrollment. Ability to swallow the drugs studied. Willing and able to meet the schedule of study assessments. Agree and sign an Informed Consent.	Presence of clinical conditions related to vivax malaria requiring hospitalization (coma, respiratory dysfunction, or severe anemia). Presence of febrile conditions because of another disease than malaria (for example: measles, acute respiratory tract infection, diarrhea with dehydration) or another chronic or severe comorbidities(for example: renal, cardiac or hepatic disease, and HIV/AIDS). Use of drugs that may affect the pharmacokinetics of antimalarial drugs in study, such as antacids may reduce the chloroquine absorption, cimetidine because the pharmacological effects of chloroquine may be increased, Quinacrine given increase in the toxicity of primaquine and drugs that change gastrointestinal motility, and in case of reported use of concomitant medications will be held on the database query Drug Interaction Checker (http://www.medscape.com/druginfo/druginterchecker?cid=med). Hypersensitivity to drugs in study. Presence of glucose-6-phosphate dehydrogenase, already known. Any disease or clinically significant findings during the medical evaluation or physical examination that, in the investigator&apos;s opinion, may interfere with the study. However any decision will be recorded in the records of recruitment to avoid selection bias. Pregnancy or lactation. Indigenous. Use of antimalarial treatment in a period less than 63 days before symptoms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-9zxb97	Use of Infrared Laser in Vaginal Delivery	Recruitment completed	Intervention	2011-06-21	<NULL>	<NULL>	187	Use of Infrared Laser in Vaginal Delivery with Episiotomy: Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Financiamento Próprio - Bolsa Mestrado do CAPES	Escola de Enfermagem da Universidade de São Paulo - EEUSP	https://ensaiosclinicos.gov.br/rg/RBR-9zxb97	<NULL>	Healthy women aged over 18 years. With term pregnancy (between 37 and 41 weeks and 6 days of gestation). Without previous vaginal birth. Having had spontaneous delivery with mediolateral episiotomy without perineal laceration. Episiorrhaphy performed with catgut simple. Single fetus in cephalic presentation and live. Not presenting an infectious disease, hemorrhoids, bruising or varicose veins in vulva-perineal region. Did not have any preparation of the perineal area during pregnancy. Do not use drugs photosensitising endogenous or exogenous. Not present clinical or obstetric complications.	Use any product in vulva-perineal region, other than soap and water.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-8ztcv9	Impact of Intervention Dietary Approaches to Stop Hypertension(dash) in Hypertension and Nutritional Status of Patients Monitored in Primary Health	Recruitment completed	Intervention	2011-06-27	<NULL>	<NULL>	188	Impact of Intervention Dietary Approaches to Stop Hypertension(dash) in Hypertension and Nutritional Status of Patients Monitored in Primary Health	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal do Maranhão	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8ztcv9	<NULL>	Hypertension enrolled in the program HIPERDIA Ministry of Health and regular monitoring in primary health care unit.	Pregnant, patients with chronic kidney disease and Renal Replacement Therapy and chronic illnesses comsuptiva.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-5dcz6y	Religiousness and the Quality of Life of Adventists: Clinical Trial	Recruitment completed	Intervention	2011-06-27	<NULL>	<NULL>	189	Parish Nursing and Quality of Life of Adventists: Clinical Trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-05-01	FACULDADE ADVENTISTA DA BAHIA	Gina Andrade Abdala	https://ensaiosclinicos.gov.br/rg/RBR-5dcz6y	<NULL>	Being a member of the Seventh Day Adventist Church, have 35 years or more. Membership in the church means to one who is christened and it regular member of the church records, which may or might not be frequenting weekly.	To refuse to participate in this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-58n26h	Effect of Education on Learning and the Diabetes Control in Patients Alloy Hypertension UFG	Data analysis completed	Intervention	2011-06-27	<NULL>	<NULL>	190	Effect of Educational Intervention on the Knowledge and Control of Diabetes in Patients of the Hypertension League of UFG	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-04-01	Dalma Alves Pereira	Dalma Alves Pereira	https://ensaiosclinicos.gov.br/rg/RBR-58n26h	<NULL>	Being patient with non-insulin dependent diabetes. Not be participating in another research project. Having physical and economic conditions for the displacement. Agree to participate and signing the consent form.	Being insulin dependent. Having obesity grade III. Miss the scheduled service. Does not agree to participate in research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-7zmz55	Light Therapy for Treatment of Lesions of the Nipple	Recruitment completed	Intervention	2011-07-03	<NULL>	<NULL>	191	Photobiomodulation as a New Approach for the Treatmment of Nipple Traumas: A Pilot Study	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2010-01-01	PUC Minas	PUC Minas	https://ensaiosclinicos.gov.br/rg/RBR-7zmz55	<NULL>	To participate in the study, women should have a medical diagnosis of nipple trauma were not infected and aged 18 to 35 years.	Exclusion criteria was considered: previous history of cancer, use of other therapeutic modalities that might interfere with the healing of the lesions, presence of infected wounds, history of photosensitivity to light, cognitive deficits that undermine the understanding and implementation of guidelines of care for breast.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-57pdy8	Association of Lipid Concentration in the Blood Cells with Clinical Status of Pediatric and Adolescent Patients with Cystic Fibrosis Supplemented with Fish Oil	Recruitment completed	Intervention	2013-05-06	<NULL>	<NULL>	192	Association of Fatty Acid in Erythrocytes with the Clinical Status of Pediatric and Adolescent Patients with Cystic Fibrosis Supplemented with Oil Rich in Omega-3	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-06	Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira	Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-57pdy8	<NULL>	Patients with cystic fibrosis, between 5 and 19 years of age, attended the National Institute of Women&apos;s Health Child and Teenagers Fernandes Figueira.	Patients with liver disease, steatorrhea, diarrhea and vomiting uncontrolled, exacerbation of the disease, indicating lung transplant, pregnant teens, and patients without adherence to medication and nutrition treatment, patients using supplements with omega-3 within 3 months before the study began.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-8mx5g6	Influence of Captopril use on Blood Pressure Response Measured After a Single Bout of Strength Exercise in Men with High Blood Pressure	Recruiting	Intervention	2011-07-03	<NULL>	<NULL>	193	Effect of Captopril use on Blood Pressure Response After a Single Bout of Resistance Exercise in Hypertensive Men	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2011-07-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-8mx5g6	<NULL>	Men. Aged between 30 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.	Subjects with obesity (body mass index equal or greater than 30 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Subjects who do not tolerate the study medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-43c2vv	Analysis of Two Physical Exercise Trainings in Elderly Over 80 Years	Recruitment completed	Intervention	2013-05-09	<NULL>	<NULL>	194	Analysis and Comparison of Two Physical Exercise Trainings and Their Detraining in Oldest Old	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-43c2vv	<NULL>	Inclusion criteria are age between 80 and 95 years old, live in community, sedentary lifestyle and ability to walk without help from another person with/without aid walking at least 500 meters.	Exclusion criteria are any cardiovascular or infectious comorbity described in the absolut contraindications list of Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aneurism of aorta, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardical infarction, acute myocarditis, pulmonary or acute systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias). Relative contraindications of cognitive, neurological and/or musculoskeletal comorbidities which make participation in protocols impossible. Score in mini-state examination mental below the cutoff score designated by education level.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-6hk9p6	Improve Immunity Through the Physical Exercise to Heart Patients	Data analysis completed	Intervention	2013-05-15	<NULL>	<NULL>	195	Improves the Immune System Through of Exercise for Patients with Chronic Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Núcleo de Cardiologia e Medicina do Exercício (NCME)	Universidade do Estado de Santa Catarina (UDESC)	https://ensaiosclinicos.gov.br/rg/RBR-6hk9p6	<NULL>	Patients diagnosed with Chronic Heart Failure functional class II and III of Ischemic or hypertensive. Ejection fraction less than 45%. Male. Minimum age 35 years and and maximum of 80 years old. Clinically Stable and being Released by medical assistant to join the program of cardiopulmonary and metabolic rehabilitation through exercise. Not having made or had complications hospitalization in the last month. Sedentary.	To have present as uneventful clinical decompensation with or without hospitalization. Stop taking medicine without doctor consent. Introduced in acute inflammatory diseases. Being patient with primary pulmonary hypertension, pulmonary infections or active pulmonary thromboembolism. Being with clinically decompensated systolic blood pressure above 180mm Hg. Being patient with renal failure, unstable angina, ventricular arrhythmia, have histories of cardiac events (acute coronary syndrome, cardiac surgery, myocardial infarction) within the last four months. Introduced orthopedic or neurological limitations that prevent them from doing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-5v3kg9	Treadmill Gait Training for Children with Cerebral Palsy	Recruitment completed	Intervention	2012-03-08	<NULL>	<NULL>	196	Treadmill Training Without Body Weight Support on Children with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Nove de Julho	Centro de Neurocirurgia Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-5v3kg9	<NULL>	Children with cerebral palsy. Age between three and 12 years. Absence of cognitive or visual impairment that could compromise the performance of the tasks. Levels I, II and III of the Gross Motor Functional Classification System (GMFCS). Functional ambulation for at least 12 months.	Orthopedic surgical procedures or neuromuscular block in the 12 months prior to the training sessions. Presence of orthopedic deformities with surgical indications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-5qzs8h	Static Balance in Children with Cerebral Palsy Submitted to Neuromuscular Block and Neuromuscular Electrical Stimulation	Recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	197	Static Balance and Function in Children with Cerebral Palsy Submitted to Neuromuscular Block and Neuromuscular Electrical Stimulation: Study Protocol for Prospective, Randomized, Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Node de Julho	Universidade Node de Julho	https://ensaiosclinicos.gov.br/rg/RBR-5qzs8h	<NULL>	Age between five and 12 years. Spastic, diplegic cerebral palsy. Motor function classified as Level I, II or III by the GMCFS. Independent ambulation with or without the need for a gait-assistance device (walker or crutches). Dynamic equinus with indication for neuromuscular block with BT-A in the triceps surae. Availability for physical therapy twice a week for four months. The following inclusion criteria will also apply to one group of children: 1) degree of cooperation compatible with the administration of NMES and 2) tolerance to NMES at a motor threshold level (visible muscle contraction).	Neurological or orthopedic conditions unrelated to cerebral palsy. Orthopedic surgery on the lower limbs in the 12 months prior to selection. Surgery scheduled during the period of the study. Equinus not reducible to neutral (ankle at 0 degrees) or incompatible with the use of orthoses following the application of BT-A in the triceps surae.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-9j26xd	Rehabilitation of the Mastication in Patients with Different Types of Dental Prostheses	Recruitment completed	Intervention	2013-06-10	<NULL>	<NULL>	198	Rehabilitation of the Masticatory Function in Patients with Different Types of Dental Prostheses	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Faculdade de Odontologia de Piracicaba UNICAMP	Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-9j26xd	<NULL>	The volunteers have to present good general health, without uncontrolled systemic diseases that prevent the surgical procedure of implants installation. Volunteers should have age between 40-80 years and present partially edentulism in the lower arch (Kennedy Class I) having only the canines and incisors (from 33 to 43) and total edentulism in the upper arch. The mandible alveolar ridge must have thickness bone volume that supports the installation of the implants (condition evaluated after X-ray and CT scan).	Presence of parafunctional habits, smokers, alcoholics, patients with xerostomia, patients with history of symptoms of temporomandibular joints and/or muscles of mastication pain, presence of uncontrolled systemic diseases, severe periodontal disease and/or tooth mobility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-2jtbyw	Evaluation of Preoperative Physiotherapy Influence on Postoperative Pulmonary Function of Megaesophagus Surgery	Recruiting	Intervention	2013-06-11	<NULL>	<NULL>	199	Evaluation of A Preoperative Physiotherapeutic Program Influence on Postoperative Pulmonary Function of Megaesophagus Correction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Federal do Triângulo Mineiro	Fundação Pio XII - Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2jtbyw	<NULL>	Patients diagnosed with achalasia grades III and IV. Patients with resectable esophageal cancer. Age greater than 18 and less than or equal to 75.	Patients who are operated in a period of less than two weeks after the initial assessment. Patients who do not understand the proposed treatment or who refuse to sign the Instrument of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-3vwfjs	The Use of Topiramate in the Crack Addiction	Recruiting	Intervention	2013-06-13	<NULL>	<NULL>	200	The Use of Topiramate in the Crack Addiction	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2013-02-20	Universidade Federal do Tocantins	Secretaria Municipal da Saúde de Palmas	https://ensaiosclinicos.gov.br/rg/RBR-3vwfjs	<NULL>	Exclusively dependence of crack cocaine. Male gender. Aged between 18-50 years.	Neurological diseases and serious mental disorder. Volunteers already under use of drug therapy for addictions to the crack cocaine. Of multiple drugs users, substance dependents addition to the crack cocaine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-6k7mrf	Effects of Muscle Energy Technique on Neck Range of Motion and Head Position	Recruitment completed	Intervention	2013-07-02	<NULL>	<NULL>	201	Effects of Muscle Energy Technique on Range of Motion and Cervical Spine Position Sense of Subjects with Chronic Neck Pain	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-12-18	Faculdade Estácio de Sá de Vitória	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6k7mrf	<NULL>	Subjects presenting neck pain for more than three months.	Trauma. Pregnancy. Peripheral neurological disease. Vestibular dysfunction. Systemic neurological disease. Congenital abnormalities. Pain during manipulative procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-38fknk	Different Techniques for Lung Ventilation During Cardiac Surgeries	Recruiting	Intervention	2013-07-03	<NULL>	<NULL>	202	Assessment Alveolar Recruiting During Heart Surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-38fknk	<NULL>	Age between 19 and 90 years. Ambos sexes. Cirurgia elective coronary artery bypass grafting with or without associated procedures. Surgery of exchange and valvuloplasty. Cirurgia of aneurysms of the ascending aorta and aortic arch. Pacientes who agreed to participate in the study by signing the consent form.	Age less than 19 years or greater than 91 years. Urgent surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-33bb7k	Evaluation of humidity and temperature of inspired gases in pediatric patients under general anesthesia	Recruitment completed	Intervention	2012-01-26	<NULL>	<NULL>	203	Evaluation of humidity and temperature of inspired gases in pediatric patients under general anesthesia with different fresh gas flows and use of a heat and moisture exchanger	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-18	Universidade Estadual Paulista	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-33bb7k	<NULL>	ASA physical satus 1 or 2, weight between 10 and 30kg, estimated surgical time of at least 80 minutes	Refusal to participate, head and neck surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-3mxvc3	Silicium Pastilles Application on Feet in Cases of Lombar Pain	Data analysis completed	Intervention	2013-07-04	<NULL>	<NULL>	204	Stiper Application on Feet Reflexology Points in Cases of Lombar Pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-05	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3mxvc3	<NULL>	Be aged between 18-65 years and have constant back pain for at least 2 days.	To present pathologies like cancer and malignant lesions on the feet, such as fissures, fistulae, dermatitis, among other which may had caused damage on skin. It was also presented as an exclusion criterion to achieve a number below 10 in Oswestry Disability Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-47232z	Maltodextrin alter glycemia on Diabetics	Recruitment completed	Intervention	2013-07-08	<NULL>	<NULL>	205	Dose-Dependent Effect of  Maltodextrin on Cardiovascular and Glucose Response in Type 2 Diabetes During Aerobic Exercise	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2011-04-09	Universidade Estadual do Centro - Oeste	Universidade Estadual do Centro - Oeste	https://ensaiosclinicos.gov.br/rg/RBR-47232z	<NULL>	Type 2 Diabetes Mellitus	Physical Disability, Limiting Pathology, Age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-2tsr7g	Muscle stretching exercise and emotional stress in pregnants	Data analysis completed	Intervention	2013-07-08	<NULL>	<NULL>	206	Effectiveness of muscle stretching in cortisol levels and in emotional stress of  third trimester pregnant women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Estadual do Centro - Oeste	Prefeitura Municipal de Itapiranga	https://ensaiosclinicos.gov.br/rg/RBR-2tsr7g	<NULL>	Women aged between 18 and 40 years old in the third trimester of pregnancy. They must had medical release for physical activity, prenatal tests up-to-date, junior high school completed and agree to sign the consent for the research.	Rheumatic, neurological, metabolic and/or cardiovascular diseases, smoking and/or alcohol use, body mass index greater than 35, recent treatment with corticosteroids and regular physical activity over the past three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-8jnxtm	Effects of music on cardiovascular system	Not yet recruiting	Intervention	2013-07-08	<NULL>	<NULL>	207	Effect of different hearing stimuli on cardiac autonomic regulation	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-30	Faculdade de Filosofia e Ciências, UNESP/Marília	Faculdade de Ciências e Tecnologia, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8jnxtm	<NULL>	Healthy subjects with no experience with classical dance and musical instrument lessons.	Disorders of auditory sensitivity, cardiorespiratory disorders, neurological and other impairments that prevent the subject known to perform procedures, treatment with drugs that influence cardiac autonomic regulation, practice-classical dance for at least one year, participation in classes of any musical instrument for at least one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-7ggfkv	Comparison of two ways of using tapings in patients with back pain.	Data analysis completed	Intervention	2012-01-17	<NULL>	<NULL>	208	Comparison of two techniques for using the Kinesio Taping in patients with chronic non-specific low back pain: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Universidade Cidade de São Paulo	Equipe Ricardo Takahashi	https://ensaiosclinicos.gov.br/rg/RBR-7ggfkv	<NULL>	Chronic low back pain in patients that were seeking care; patients with chronic low back pain from the community;  Patients with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for the interventions (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis, allergy or intolerance to the material).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-5nr9xq	Analysis of cervical posture and analyze the muscles of the shoulder and upper back for individuals who may use upper and lower dentures	Recruitment completed	Intervention	2013-07-08	<NULL>	<NULL>	209	Analysis of electromyography and craniocervical posture of patients with denture bimaxillary	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Federal Alfenas	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5nr9xq	<NULL>	Individuals referred for fitting total bimaxillary older than 40 years, who agree to sign an Informed Consent	Individuals under the age of 39 years, patients with cancer who do not agree to sign an informed consent. Dentofacial deformity, trauma in the head and neck. Individuals who take muscle relaxant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-23gvd4	Use of Equipment and Resources of Physiotherapy in Morbidly Obese Patients Undergoing Stomach Reduction Surgery	Recruitment completed	Intervention	2013-07-15	<NULL>	<NULL>	210	Use of Positive Pressure in Morbidly Obese Patients Undergoing Gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Metodista de Piracicaba - UNIMEP	Universidade Metodista de Piracicaba - UNIMEP	https://ensaiosclinicos.gov.br/rg/RBR-23gvd4	<NULL>	"BMI &gt; 40 kg/m2 and &lt; 55 kg/m2; surgical procedure type gastric bypass Roux-Y, by laparotomy; age between 25 and 56 years
pulmonary function tests and thoracic radiograph normal; nonsmoker; absence of respiratory diseases"	Hemodynamic instability; abnormalities in pulmonary function test; permanence greater than three days in the hospital; presence of postoperative complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-4fw87f	Effects of Patellar Taping in Subjects with Knee Pain	Recruiting	Intervention	2013-07-15	<NULL>	<NULL>	211	Influence of Patellar Taping on Baropodometric Characteristics of Subjects with Patellofemoral Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-18	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4fw87f	<NULL>	Women aged between 18 and 35 years, with pain in the anterior knee insidious onset, no history of trauma in the region. Duration of symptoms for longer than 12 weeks and triggered by  perform two of the following activities: up or down stairs, squatting, sitting for long stay; while practicing physical activity. On physical examination must present pain in two of four tests: isometric contraction of the quadriceps, squats, palpation of the medial or lateral patellar and step down. To compose the control group will be selected women without musculoskeletal symptoms in the lower limb.	Women who underwent physical therapy for the lumbar spine, pelvis and lower limbs in the last 6 months prior to collection. With a history of neurological diseases and surgery of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-4hn597	Effect of Concurrent Training on Risk Factors and Fatty Liver in Obese Adolescents	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	212	Study of the Effects of non Pharmacological Training on Components of the Metabolic Syndrome and Fatty Liver Disease in Children and Adolescents with Overweight and Obesityobese Adolescents	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4hn597	<NULL>	Classification of obesity according to the pediatric body mass index (BMI) for age and gender, waist circumference (WC) based on the criteria for age, age between 12 and 15 years on the day of assessment, absence of clinical conditions that made physical activities impossible, a free and informed consent for participation in the program signed by the parents or legal guardians.	Participants aged not compatible with the age proposed by the program, the participant has a disease of metabolic, physical or psychological origin that could prevent the emergence of physical exercise and not be classified as obese by BMI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-2wz5kq	Selenium Concentration in Blood and Inflammatory Activity in Critically Ill Children	Recruitment completed	Observational	2013-07-15	<NULL>	<NULL>	213	Plasma Selenium Concentrations and Erythrocyte Glutathione Peroxidase Activity: Relationship to Inflamatory Response and Nutritional Status in Critically Ill Children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-06	Universidade Federal de São Paulo - UNIFESP	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2wz5kq	<NULL>	Children admitted to the Pediatric Intensive Care Unit with a diagnosis of systemic inflammatory response syndrome, sepsis, septic shock or multiple organ systems.	Neonates, children with chronic renal or hepatic impairment, and suspected inborn error of metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-8854cd	Diabetic Foot Care	Data analysis completed	Intervention	2013-07-16	<NULL>	<NULL>	214	The Use of Exercises and Instructions for Self-care in Diabetic Patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-16	Universidade Federal de Alfenas- UNIFAL-MG	Prefeitura Municipal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8854cd	<NULL>	Volunteers of both sexes, with a clinical diagnosis of type 2 diabetes for more than 5 years, with a minimum age of 30 years and maximum 85 years in routine medical monitoring in a Basic Health Unit in the city of Alfenas	Volunteers with some neurological disorders that produce balance disorders, with a history of alcoholism, herniated disc, leprosy, injuries and amputations of lower limbs, subject to inability to participate in all testing and training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-5533p2	Impact of a Physical Activity Program on Plasma Concentrations of Adipocitokines in Overweight and Obese Schoolchildren from Public Schools at Ouro Preto and Barbacena Cities, Minas Gerais State	Data analysis completed	Intervention	2013-07-16	<NULL>	<NULL>	215	Impact of a Physical Activity Program on Plasma Concentrations of Adipocitokines in Overweight and Obese Schoolchildren from Public Schools at Ouro Preto and Barbacena Cities, Minas Gerais State	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal de Minas Gerais	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5533p2	<NULL>	"Children between six and nine years enrolled in public schools in the urban area of the city of Ouro Preto.
Children whose parents consented to their participation by signing the Consent.
Children between six and nine years considered overweight and obesity."	Children aged six to nine years, with chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-29gj42	Diabetes Management from Information Transmitted by Phone Calls	Not yet recruiting	Intervention	2013-07-17	<NULL>	<NULL>	216	Control of Type 2 Diabetes Mellitus: Analysis of an Intervention Program with Information about the Disease Via Phone Calls	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2013-09-09	Universidade Federal do Ceará - Departamento de Enfermagem	Universidade Federal do Ceará - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-29gj42	<NULL>	Having type 2 diabetes for at least one year;Having more than 18 years old;Owning telephone contact;Being able to come to the unit for blood collection;Being able to self-monitoring of blood glucose and self-administration of medicines;Being able to understand the goals, methods and treatment procedures.	Owning hemoglonina glycated less than 7%;Have complications from the disease: kidney failure, blindness and amputation of limbs;Submit severe cardiovascular disease, high blood pressure or mental illness;Be participating in research with similar goals, made by other researchers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-2cxrpp	Effect of Two Kinds of Therapy on Women with Patellofemoral Pain Syndrome	Recruiting	Intervention	2013-07-30	<NULL>	<NULL>	217	Effects of Lumbo-pelvic Stabilization Training on Women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2cxrpp	<NULL>	Women agend between 18 and 30 years old, anterior or retropatellar knee pain during at least two of the folling activities: ascending/descending stairs, squating, running, jumping and prolonged sitting, insidious onset of the symptoms being unrelated to a traumatic incident and persistent for at least 8 weeks, presence of pain on palpation of the patellar facets, usual pain in the last week of at least 3cm in the Visual Analogue Scale (VAS) of 10cm.	Signs or symptoms of meniscal disorders, cruciate or collateral ligament involvement, tenderness over the patellar tendon, iliotibial band, or pes anserinus tendons, sign of patellar apprehension, Osgood-Schlatter or Sinding-Larsen-Johansson syndromes, hip or lumbar referred pain, history of patellar dislocation, evidence of knee joint effusion, previous surgery on the knee joint.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6pvzyt	Aplicattion of Hipromelosis (Ophthalmic Gel) in Lacrimal Punctum Closure in Dry Eye Patients	Data analysis completed	Intervention	2013-07-31	<NULL>	<NULL>	218	Occlusion of Inferior Lacrimal Punctun with Hypromelosis in Dry Eye Patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital Universitário de Brasília - Universidade de Brasília	Hospital Universitário de Brasília - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6pvzyt	<NULL>	"Age over 18 years; Age under 70 years;
Ambulatorial patients of HUB-Hospital Universitário de Brasília ; Dry eye patients; Patients complaining about current treatment; no other ocular diseases previously or during the study."	Develop systemic or ocular disease during the study; Initiate use of new systemic or ophthalmologic medications in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6tc7mj	Evaluation of Knee Alignment	Recruiting	Intervention	2013-08-05	<NULL>	<NULL>	219	Biomechanics of Lower Limbs Valuation Pre and Post-treatment of Individuals with Anterior Knee Pain. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-12-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6tc7mj	<NULL>	Female, aged between 18 and 28 years. Knee pain for at least 6 months. Fitness for muscle strengthening exercises and stretches.	Individuals with a history of musculoskeletal injuries in lower limbs (fractures or ligament injuries in lower limbs).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-65n292	Prevention Program of Diabetes in São Paulo	Data analysis completed	Intervention	2013-08-06	<NULL>	<NULL>	220	Analysis of the Cardiometabolic Risk Profile of a Population Sample from São Paulo City  and Implementation of a Prevention Program for the Prevention fo Type 2 Dabetes Mellitus	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Faculdade de Saúde Pública, USP	Faculdade de Saúde Pública, USP	https://ensaiosclinicos.gov.br/rg/RBR-65n292	<NULL>	Individuals with prediabetes (impaired fasting glycemia: fasting glycemia between 100 and 125 mg/dL; impaired glucose tolerance: 2-hour glucose between 140 and 200 mg/dL) or fulfilling metabolic syndrome criteria according to the International Diabetes Federation for Latin-American populations.	Medical history of neurological or psychiatric disturbances, thyroid, liver, renal and infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-5m4dt7	Effects of Different Trainings to Strengthening Pelvic Floor Muscles	Recruitment completed	Intervention	2013-08-07	<NULL>	<NULL>	221	Effects of Different Training Protocolos in Function and Electrical Activity of the Pelvic Floor Muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5m4dt7	<NULL>	Age between 18-30 years. Active sex life, defined as reporting any sexual intercourse in the last three months. Active and non-athletes, physical activity for more than 150 minutes per week. Normal body mass index (BMI) (between 18.5 and 24.9 kg/m2.	Current pregnancy or prior. Reporting of urinary leakage last week. Presence of pelvic organ prolapse. Presence of constipation, defined as weekly evacuation less than three times. Presence of pelvic pain. History of pelvic surgery. Amenorrhea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-7j5xyf	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	Not yet recruiting	Intervention	2013-08-07	<NULL>	<NULL>	222	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7j5xyf	<NULL>	Women with symptoms consistent with urinary incontinence (stress, urge or mixed) and older than 18 years and less than 80 years old.	Exclusion criteria are: virginity, pregnancy, women with gynecological cancer or bladder cancer, women diagnosed with neurological diseases (stroke, multiple sclerosis, parkinsonism, epilepsy, tumor or spinal cord trauma), observed cognitive deficits  (minimental &lt;14), difficulties in performing activities of daily life, not agreeing to participate in the study by signing the consent of the ethics committee,those who can not contract adequately pelvic floor during pelvic floor muscle assessment and women who previously held treatment with  pelvic floor exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6xhgzb	What is the effect of iontophoresis in the treatment of patients with primary palmar hyperhidrosis?	Data analysis completed	Intervention	2013-08-07	<NULL>	<NULL>	223	Treatment of Palmar Hyperhidrosis with Iontophoresis: Case Reports	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-10	Universidade Católica do Salvador	Universidade Católica do Salvador	https://ensaiosclinicos.gov.br/rg/RBR-6xhgzb	<NULL>	Individuals of both sexes who had bilateral primary palmar hyperhidrosis	Individuals presenting metallic implants in the upper limbs, impaired sensation in the hands of, who used drugs that caused the malfunction, or perform some other type of treatment for hyperhidrosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-55jf6q	Efficacy and Safety Evaluation of HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions.	Recruiting	Intervention	2013-08-08	<NULL>	<NULL>	224	Efficacy and Safety Evaluation of  Silicone Stent in the Treatment of Central Airway Obstructions.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Ministério da Saúde	Hospital de Clinica de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-55jf6q	<NULL>	Consent to participate in the study by signing (by the patient or family / legal guardian when aplicable) of the Informed Consent Form; 18 years old or more;  clinically significant stenosis (symptomatic or about to become symptomatic) in the trachea, main bronchus or intermediate bronchus, which can be treated after a stente implant.	Clinical or absolute anesthesic contraindication of the rigid bronchoscopy under general anesthesia;constitutional or acquired anatomic limitations that prevent the rigid bronchoscopy;another indication of exclusive preferential treatment modality for stenosis (surgery, radiotherapy, chemotherapy, other).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-3vmkt2	A Prospective Single Arm, Open-label, International, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Atazanavir (ATV) Powder Boosted with Ritonavir (RTV) Liquid with an Optimized NRTI Background Therapy, in HIV Infected Pediatric Patients Greater Than or Equal to 3 Months to Less Than 6 Years. (Pediatric Atazanavir International Clinical Evaluation: the PRINCE I study)	Recruitment completed	Intervention	2011-06-13	<NULL>	<NULL>	225	A Prospective Single Arm, Open-label, International, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Atazanavir (ATV) Powder Boosted with Ritonavir (RTV) Liquid with an Optimized NRTI Background Therapy, in HIV Infected Pediatric Patients Greater Than or Equal to 3 Months to Less Than 6 Years. (Pediatric Atazanavir International Clinical Evaluation: the PRINCE I study)	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2010-11-01	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-3vmkt2	<NULL>	HIV 1 infection diagnosed by protocol criteria. &gt;= 3 months to &lt; 5 years and 6 months of age at time of first treatment, and weight &gt; 5 to &lt; 25kg with any screening baseline plasma viral load. Antiretroviral naive and experienced. Screening HIV RNA &gt;= 1000 copies/mL. Must have genotypic sensitivity at screening to ATV and at least 2 NRTIs. NRTIs must be approved for pediatric use at the local country. Subjects must have documented genotypic and phenotypic sensitivity at screening to ATV (Fold Change in susceptibility &lt; 2.2) and to at least 2 NRTIs that are approved in their country.	Experienced subjects who received ATV or ATV/RTV at any time prior to study enrollment or who have prior history of 2 or more PI failures. Antiretroviral-naïve or experienced HIV-1 infected patients with contraindication to study medications. Family history of QTc interval syndrome, Brugada syndrome or right ventricular dysplasia or with a corrected QTc interval at screening of &gt; 440 ms. One of the following cardiac rhythm abnormalities documented on the screening ECG: First degree atrioventricular (AV) block as defined by protocol. Type I second degree AV block while awake, type II second degree AV block at any time, complete AV block at any time, or age-adjusted heart rate &lt; 2nd percentile). Use of Tenofovir.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-78tbws	Effect of hydration on the mechanisms responsible for changes in blood pressure  after one session of aerobic exercise.	Recruiting	Intervention	2013-08-13	<NULL>	<NULL>	226	Effect of hydration on blood pressure response after exercise and its mechanisms.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78tbws	<NULL>	"Healthy men
Sedentary
Aged 18 to 35 years"	"Individuals trained
Hypertension (systolic and diastolic blood pressures greater than or iqual to 130/85 mmHg)
Obesity (body mass index greater than or equal to 30kg/m2)
Smokers
Diabetes (fasting glucose greater than or equal to 126 mg / dl)
Heart diseases (previous diagnosis or change in rest or exercise ECG)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-4x2957	Study of the therapies for dentin hypersensitivity.	Not yet recruiting	Intervention	2013-08-13	<NULL>	<NULL>	227	Comparative study of therapies for the treatment of non-carious cervical lesions with dentinal hypersensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-20	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4x2957	<NULL>	"The volunteers: they will be included with age 18 years or older,  enrolled in the clinics of dentistry UFPI having at least 20 dental elements.
Non-carious lesions: at least four lesions whose sensitivity is classified by the patient for moderate to severe after administration of a air, and tooth wear between 2 and 4. These teeth must have an antagonist tooth."	"The patient: will be excluded  people who have made periodontal treatment and/or hypersensitivity treatment in the last six months, patients with bruxism in the active phase.
Non-carious lesions: teeth with very deep lesions, when a ruber dam isolation is not possible and those that have been previously restored."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-7ddb5s	Evaluation of hormonal acne in adult women and its treatment with two different therapies.	Not yet recruiting	Intervention	2013-08-13	<NULL>	<NULL>	228	Contribution to the study of acne in adult women: analysis of the correlation between peripheral androgen conversion and its influence on the expression of toll-like receptors 2 and CD1d in areas with and without inflammatory acne lesions and its modulation by treatment with oral contraceptive or topical cream with anti-androgen activity.	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-03-01	UNIFESP-EPM	fleury laboratório	https://ensaiosclinicos.gov.br/rg/RBR-7ddb5s	<NULL>	"To all:

Signing the consent form before any study procedures;
women aged 26-44 years, not pregnant and in good health;
no topical treatment for acne in the last three months, except sanitizers;
Lack of use of oral antibiotics in the last 3 months;
Absence of the use of isotretinoin in the last two years;
Absence of oral contraceptive use in the last 3 months;
Absence of clinical evidence of immunosuppression and
accordance with the conditions of study, ability to understand and strictly follow the instructions received.

For the group treated with oral contraceptives:
Absence of contraindications to the use of hormonal contraceptives.

For the group treated with azelaic acid:
Absence of skin hypersensitivity to azelaic acid."	"Women who do not agree with the conditions of the study or without the ability to understand and strictly follow the advice they had received no willingness to attend the revaluations or refuse to sign the Informed Consent;
Pregnant or lactating women; 
Use the following oral medications: cortisone derivatives, lithium, anticonvulsants, isoniazid, oral contraceptives, androgens, danazol, iodides, bromides, disulfiram, cyclosporine, azathioprine, tiuréias, vitamins B2, B6 and B12;
Treatment of facial skin with topical retinoids (tretinoin and adapalene), azelaic acid, benzoyl peroxide, clindamycin, erythromycin, nicotinamina, singly or in combination, in the last 3 months;
Treatment with oral antibiotics in the last 3 months;
Use of cosmetics acnogênicos;
Presence of contraindications to oral contraceptive use (smoker over 35 years;
history of deep venous thrombosis, history of stroke, history of breast cancer, presence of jaundice, and severe active liver disease or biliary disease;
diabetes mellitus for more than 20 years or eye injury, neurological or renal arterial pressure greater than or equal to 160 to 100 for systolic and diastolic;
cardiovascular disease and the presence of severe headache associated with blurred vision often) for the group treated with oral contraceptive;
Presence of allergic symptoms and / or irritating to the use of azelaic acid for the group treated with azelaic acid;
History, clinical signs and / or laboratory hyperandrogenism prior to a control group;
Presence of inflammatory acne on the face for the control group 2."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6j944w	Evaluation of intensive treatment of cellulite aesthetics.	Recruitment completed	Intervention	2013-08-13	<NULL>	<NULL>	229	Evaluation of intensive treatment of cellulite aesthetics.	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-02	Vascular Laser Center-Clinica Godoy	FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-6j944w	<NULL>	Body weight compatible with the height.	Obesity, edema, other evidence clinical disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-2t37vy	Validation of Jebsen-Taylor Hand Function Test for Muscular Dystrophy	Recruiting	Intervention	2013-08-19	<NULL>	<NULL>	230	Validation of Portuguese Version of Jebsen-Taylor Hand Function Test for Patients with Muscular Dystrophy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t37vy	<NULL>	"Individuals with Duchenne Muscular Dystrophies types, Waistlines, Congenital, Fascioescapuloumeral and Myotonic with diagnosis confirmed
by immunohistochemical and / or muscle biopsy, which have seven years of age or older and who were monitored
Clinical Brazilian Association of Muscular Dystrophy, individuals who underwent surgical procedures in upper and / or spine, concordance in research participation by signing the consent form"	Difficulty understanding simple verbal commands, deficits-visual and / or auditory preventing the implementation of the research protocol, presence of associated neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-8zk8sz	The use of massage therapy as specific points for the feet of diabetic patients	Recruitment completed	Intervention	2013-08-19	<NULL>	<NULL>	231	The use of reflexology feet as treatment for patients with diabetes mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-12-17	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8zk8sz	<NULL>	With diabetes mellitus type II diagnosed for at least five years; Registered in HIPERDIA; Age above eighteen years; participate voluntarily in the study after signing the consent form.	Foot ulcers, amputations of the lower limbs, diagnosed hypertension, thrombosis, deficits in cognitive ability, previous treatment with reflexology, give up voluntarily participate in the research at any time of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-2h3wjn	Inflammatory and Gene Response to Diet	Recruitment completed	Intervention	2013-08-19	<NULL>	<NULL>	232	Inflammatory Response To Consumption Of Specific Dietary Compounds: A Nutrigenomic Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-05-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-2h3wjn	<NULL>	Women, age between 20-40 years-old, normal-weight (BMI: 18,5-24,9 kg/m2) or overweight/Obesity (BMI: 25,0-35,0 kg/m2), no smokers	"Pregnancy or lactiontion or menopause.
Infections or inflammation in the experiment days; Inflammatory, heart, liver, renal, gastrointestinal and respiratory diseases; Hormonal treatment or prescribed drug that affect glucose metabolism; Alcoholic or drug dependence; Smoking; Recent follow-up of diets designed to weight loss or unstable weight in the last three months (higher than 5% usual weight); To be athlete"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-3ss6zt	Comparation of Physiotherapu Approach Using Weights and Elastic Bands on Respiratory Function	Recruiting	Intervention	2013-08-21	<NULL>	<NULL>	233	Comparation of Proprioceptive Neuromuscular Facilitation with Resistive Exercise of Fixed Load and Elastic Load on Respiratory Function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3ss6zt	<NULL>	Normotensive, aged 18-25 years, not smoking, right-handed according to the Inventory of the Edinburgh Handedness, sedentary.	Underweight and obese according to body mass index, heart disease, lung disease, musculoskeletal disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-9zmfs9	Evaluation of Green Propolis as a oral Anti-inflammatory Drug	Recruiting	Intervention	2013-08-21	<NULL>	<NULL>	234	Evaluation of Clinical Safety and Efficacy of an Anti-inflammatory Abtained from Active Ingredient of the Brazilian Biodiversity	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2013-01-01	Faculdade de Medicina de Ribeirão Preto - FMRP	Apis Flora Ind. Com. Ltda	https://ensaiosclinicos.gov.br/rg/RBR-9zmfs9	<NULL>	Healthy volunteers of both genders, non-smokers, aged 18 to 60 years and weighing within 15% of the normal weight for men and women taking into account their height and physical structure will be included. Participation of female volunteers is conditioned to not be pregnant or breastfeeding.	Volunteers with a history of smoking, alcoholism or drugs abuse, diagnosed as having any cardiac, renal, gastrointestinal, hepatic and pulmonary disease, neurological, psychiatric, hematological or metabolic disorders will be excluded. Also individuals with any known hypersensitivity to drugs who are receiving medications one week before the study or during its implementation and not willing to participate in all stages of this study will not be accept.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8f6wr7	Knowledge about healthy habits and risk factors for cardiovascular diseases a group of students	Recruitment completed	Intervention	2013-08-22	<NULL>	<NULL>	235	Knowledge about Healthy Habits and Risk Factors for Cardiovascular Disease in a Group of Children 4 The 5th Series of Elementary School	<NULL>	4, randomized-controlled, n/a	4	<NULL>	<NULL>	<NULL>	2012-03-15	Instituto de Cardiologia	Instituto de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8f6wr7	<NULL>	"Children aged 7 to 11 years old.
Authorization from parents."	"Children under seven years.
children over 11 years.
cognitive problems."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8nxn75	Effects of Cervical Manipulation on Upper Limb Motor Control in Subjects with Neck Pain	Data analysis completed	Intervention	2013-08-26	<NULL>	<NULL>	236	The Effect of Motor Control Deficits and Physical Therapy Interventions on the Grip Force Control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8nxn75	<NULL>	History of three or more neck pain episodes in the past three months.	Previous history of rheumatic disease, cervical myelopathy, tumors, central or peripheral neurological disorders. History of major trauma, fracture or surgery in the neck, shoulder and/or upper limb. Signs of nerve root compression as important muscle weakness affecting the upper limbs, reduction or loss of biceps and triceps reflexes, decreased sensation in the dermatomes of the upper limb. Red flags contraindicating cervical manipulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-596tn3	Effectiveness of manual lymphatic drainage on lymphedema of the lower limbs compared with the massage technique with smooth movements in reducing lymphedema lower limb.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	237	Evaluation of lymphatic drainage and massage  to reduce lymphedema.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Vascular Laser Center Ltda-Clinica Godoy	Vascular Laser Center Ltda-Clinica Godoy	https://ensaiosclinicos.gov.br/rg/RBR-596tn3	<NULL>	Patients with lymphedema of lower limbs, clinical diagnostic or lymphoscintigraphy,  without active infection or skin lesion. Both sexs ranging in age from 21 years and maximum 75 years.	Absence of lymphedema, presence of active infection or clinical contraindication for lymphatic drainage such as renal or cardiac decompensation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-2jcys5	Blood pressure increase during strength exercise conducted with different loads in people with high blood pressure treated with amlodipine.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	238	Intra-arterial blood pressure responses during resistance exercise of different intensities in hypertensive patients treated with calcium channel antagonist.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-09-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-2jcys5	<NULL>	"Essential hypertension
Men and Women
30 to 60 years
Sedentary
No target organ damage or secondary causes of hypertension according to the diagnostic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, University of Sao Paulo."	"Individuals with obesity (body mass index greater than or equal to 35 kg/m2),
Individuals with diabetes (fasting glycemia greater than or equal to 126 mg / dl),
Individuals with heart disease (previous diagnosis or alteration at rest or exercise ECG),
Average blood pressure greater than or equal 160/105mmHg.
Subjects who do not tolerate the study medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-75scwh	Comparison of Two Types of Training in Physical and Organic Performance	Data analysis completed	Intervention	2013-07-08	<NULL>	<NULL>	239	Effects of Concentric vs Eccentric Resistance Training in Clinical, Functional, Cardiovascular and Biological Parameters	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-75scwh	<NULL>	Adults with age between 18 and 30 years old, be male, self declared healthy and no medical restriction for physical activity, classified as physically active by IPAQ (International Physical Activity Questionnaire)	Subjects with cardiovascular, respiratory and/or metabolic disorders, alcoholic, smokers, injury episode osteoarticular or muscle-tendon in the lower limbs and/or column in the last year and did participate in weight-training program for at least 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-3vg4fd	Translation and Adaptation for Assessment of Trunk Control	Recruiting	Observational	2013-09-01	<NULL>	<NULL>	240	Translation and Adaptation Assessment of Trunk Control (SATCo)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-09-09	UNIFESP	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-3vg4fd	<NULL>	Individuals of both sexes and showing any kind of muscular dystrophy, aged 7 to 30 years	Patients without at least control head, which have recently undergone surgery of the spine, and exhibiting severe deformities in the spine. Patients whose parents and  or guardian, or the individual himself does not sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-96jrm5	Comparison between conventional physical therapy and Pilates&apos; Method in the evolution of functionality, respiratory muscle strength and exercise capacity in hospitalized chronic renal patients	Recruiting	Intervention	2013-09-01	<NULL>	<NULL>	241	Effectiveness of conventional physical therapy and Pilates&apos; method in functionality, respiratory muscle strength and ability to exercise in hospitalized chronic renal patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-09	UNIVERSIDADE CIDADE DE SÃO PAULO	Hospital do Rim e Hipertensão	https://ensaiosclinicos.gov.br/rg/RBR-96jrm5	<NULL>	No acute neuropathy or lung disease, or also rheumatic and orthopedic diseases associated that prevent them from performing the proposed protocol; those who have cognitive ability to respond to the questionnaire and ability to ambulate.	Will be excluded immediate postoperative abdominal surgery, from the upper or lower abdomen; those who present, at the time of hospitalization, the need for use of noninvasive mechanical ventilation and intubation; those who present thrombocytopenic; those with diagnosis of deep vein thrombosis and who require intensive medical support	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-64mbnx	Yôga and Respiratory Techniques on HF Patients	Other	Intervention	2013-09-02	<NULL>	<NULL>	242	Yôga and Respiratory Techniques Training on the Management of Heart Failure Patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	HCPA- UFRGS	HCPA- UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-64mbnx	<NULL>	"Stable HF patients in an ambulatory care setting at ULBRA-Mãe de Deus University Hospital, with a diagnosis of HF with Preserved or Reduced Fraction.
Aged 45 to75 years old.
Functional Class II and III.
No exclusion criteria for physical activity, in accordance with clinical evaluation performed by a cardiologist in charge."	"Not signing the Informed Consent.
Not being able to do physical activity (angina, AMI with less than 6 months and / or stenting with persistent angina, severe valvular disease, chemotherapy, implanted defibrillator, NYHA functional class IV, medium and severe COPD).
Not completing intervention or evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5qrt8h	Effectiveness of denture adhesives in chewing of complete denture wearers	Data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	243	Effectiveness of denture adhesives on the kinesiographic records and satisfaction of complete denture wearers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-10	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5qrt8h	<NULL>	"Adults;
Mentally agile and responsive;
Resilience and alveolar volume normal; Absence of dysfunctions in the stomatognathic system;
Absence of debilitating systemic changes."	"Debilitating neurological or systemic diseases;
Cardiac pacemaker;
Need for pre-prosthetic surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5ktv6b	Home fortification of complementary feeding in Brazil: a multicenter pragmatic trial	Recruitment completed	Intervention	2013-09-11	<NULL>	<NULL>	244	Effectiveness of home fortification with vitamins and minerals for the prevention of iron deficiency and anemia in infants younger than 1 year of age: a multi-center study of Brazilian cities.	<NULL>	3, non-randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2012-06-13	Ministério da Saúde	CNPq	https://ensaiosclinicos.gov.br/rg/RBR-5ktv6b	<NULL>	"Intervention group: infants between 6 and 8 months at the enrollment(6 months before outcome measures) 
Control group: infants between 12 and 14 months at outcome measures"	Reported cases of malaria, positive for  HIV, tuberculosis, hemoglobinopathies, and in treatment for anemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4j9jpr	Use of insoles on the improvement in individuals after stroke.	Recruiting	Intervention	2013-09-16	<NULL>	<NULL>	245	Postural Insoles Influence  on  Functional Capacity of Individuals Post-Stroke: Study Randomized Controlled Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Universidade Nove de Julho - Uninove - SP	Universidade Nove de Julho - Uninove - SP	https://ensaiosclinicos.gov.br/rg/RBR-4j9jpr	<NULL>	Participants will be selected based on the eligibility criteria: have a diagnosis of both hemorrhagic stroke as ischemic, with spastic hemiplegia, spasticity classification by modified Ashworth scale levels 1, 1 + and 2 have walk independently without the use of any device auxiliary or ankle-foot orthosis (AFO), have degrees of understanding and collaboration consistent with the achievement of the proposed activities, agree to participate in the study by signing the consent form.	Individuals with stroke who have undergone surgical procedures or the application of phenol in the last 12 months or neurolytic blocks in the last 6 months, and ankle deformities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8gcx9m	Non-randomized clinical trial to assess the effect of a medication against cytomegalovirus in patients who are not infected originally cytomegalovirus but who have received renal transplantation from donors that are infected by cytomegalovirus.	Recruiting	Intervention	2012-11-06	<NULL>	<NULL>	246	A phase 2a single arm study to evaluate the effect of TCN -202 (human anti-cytomegalovirus monoclonal antibody) on CMV infection in CMV (cytomegalovirus) seronegative recipients of kidney allografts from CMV seropositive donors	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2013-08-27	Theraclone Sciences, Inc	Worldwide Clinical Research Monitoramento de Pesquisas Clínicas do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8gcx9m	<NULL>	Patients who are males or females aged 18 to 65 years, inclusive;Patients who are single-organ recipients (kidney only) and CMV seronegative and receiving a kidney transplant from a CMV seropositive (cadaver or living) donor;Females must not be pregnant or nursing and must either be of non-childbearing potential or must agree to use 2 acceptable methods of birth control and must agree to continue doing so for four months after the last dose of TCN-202;Females of childbearing potential and males with female partners with childbearing potential must agree to use effective contraception and must agree to continue doing so for four months after TCN-202 dosing;Adequate venous access and able to receive intravenous infusion;Patients must be able to understand the purpose and risks of the study and sign the informed consent form (ICF).	Patients who require anti-lymphocyte preparations for induction therapy (indication in the rejection of transplanted organs) or those who receive a kidney with a cold ischemia time higher than 30 hours;patients presenting any acute medical condition or significant past medical history or any condition that in the opinion of the Principal Investigator (PI) or the Sponsor would complicate or compromise the study, or the well-being of the patient;Patients with known positivity to Hepatitis B, Hepatitis C and HIV (1 and 2);Patients with history of cancer (except for non-melanoma skin cancer) within 2 years prior to transplantation;patients with history of drug or alcohol abuse within 6 months prior to transplantation;patients who have received an investigational product in any clinical trial within 12 months of transplantation;patients who have received prior treatment with a monoclonal antibody;Patients who require concomitant treatment with other investigational drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-237v4b	Effectiveness of an phythetapic in prevention and treatment of skin lesions caused by radiotherapy in patients with Head and Neck Cancer	Recruiting	Intervention	2013-09-16	<NULL>	<NULL>	247	Evaluating the efectiveness of calendula in the prevention and treatment of Head and Neck Radiodermatitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-03	Hospital Erasto Gaertner - HEG	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-237v4b	<NULL>	"Age above 18 years,diagnosis of cancer and head and neck radiotherapy, intact skin and continuous in the head and neck, first day of radiotherapy (if new), patients with no previous history of radiotherapy in the same field / local radiation,
Consent to participate in by signing the consent form (ICF)."	Previous reports of allergic reaction in the use of one of the research products (essential fatty acids or marigold).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-9j4thm	Effects of the use of non-invasive ventilation on breathing in children after cardiac surgery	Recruitment completed	Intervention	2013-09-16	<NULL>	<NULL>	248	Lung function in the postoperative period of cardiac surgery after use of continuous positive airway pressure (CPAP)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-24	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9j4thm	<NULL>	"Children of both sexes aged 7-16 years, stable, who are undergoing cardiac surgery with median sternotomy during the study period.
Informed consent approved and signed by the heads."	"Children who present:
Hemodynamic instability (represented by fever, decrease or increase of 20 mmHg of the reference value of blood pressure or heart rate 20 bpm and severe hypoxemia);
Presence of contraindication to NIV
Respiratory distress (represented by increased respiratory rate (RR) according to age, increased work of breathing with the presence of runs intercostal, subcostal, and  or paradoxical pattern);
Children unfit to perform the technique (under sedation, decreased level of consciousness or who refuse to participate in the study)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-6fftwy	Evaluation of walking in patients with Parkinson&apos;s disease who underwent surgery for brain stimulation before and after physical therapy program with exercises and treadmill training with or without body weight support.	Other	Intervention	2013-09-16	<NULL>	<NULL>	249	Three-dimensional analysis of gait in patients with Parkinson&apos;s disease and deep brain stimulation before and after regular cinesioterapia program with treadmill training with and without partial body weight support	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-02	Faculdade de Medicina da Universidade de São Paulo	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6fftwy	<NULL>	Indication of the implant deep brain stimulation; Over 18 years of age, clinical diagnosis of idiopathic Parkinson&apos;s disease according to international criteria, absence of adequate response to treatment with medication or with complications related to prolonged use of L-dopa; Expected to be anesthesia or local anesthesia or general do not incur greater risk than expected in the general population; Ability to understand and sign the consent form; Blood tests, coagulation and normal metabolic; Absence of anatomic abnormalities that preclude access to the implant the electrodes (cranial tumors, intra-cranial and brain cysts), absence of infection or other medical conditions pre-existing non-controlled (diabetes, hypertension, symptomatic pulmonary or cardiac diseases) no use of antiplatelet agents, not being performing concurrent treatment with other experimental drugs; Absence of pregnancy and breastfeeding; conditions psychological, familial, sociological or geographical impossible medical monitoring post-operative Fitness for Motor Training Program, Maintenance of good clinical conditions previously described; Maintenance of all clinics and drug restrictions described; Installation of deep brain stimulation (DBS) for two months at least; DBS working properly at the time of inclusion; Accept and sign the consent form to participate in the training program.	Inability to consent to participate in the study: With uncontrolled infection or other medical conditions pre-existing non-controlled (eg decompensated diabetes, hypertension, pneumonia or symptomatic heart disease), history of primary or secondary myocardial ischemia, congestive heart failure, cardiac arrhythmia, or bundle branch block refractory to treatment, concomitant treatment with other experimental drugs, pregnant or lactating; Conditions psychological, familial, sociological or geographical conditions that preclude medical monitoring post-operative history of orthopedic surgery of lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8ftzft	Electrical Stimulation for postoperative pain control after liposuction sugery.	Recruitment completed	Intervention	2013-09-18	<NULL>	<NULL>	250	Transcutaneous Electrical Nerve Stimulation for pain control after Liposuction	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-10-04	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8ftzft	<NULL>	The study included female patients, aged between 18 and 40 years old, healthy, with a body mass index less than 24.9, underwent liposuction of the abdomen, back and flanks.	We excluded in the study subjects who used alcohol, smoking and drugs, systemic diseases, even if controlled by medication, with the presence of low back pain for more than 6 months and prior use of transcutaneous electrical nerve stimulation (TENS).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-34khhv	Effect of Physical Exercise and Respiratory Therapy After Cardiac Surgery	Recruiting	Intervention	2013-09-19	<NULL>	<NULL>	251	Impact of Physical Exercise Associated to CPAP Application on Coronary Artery Bypass Grafting Surgery Postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-12	Universidade Federal de São Carlos	Irmandade da Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-34khhv	<NULL>	Volunteers with clinical diagnosis of coronary artery disease by coronary angiography and absence of acute or chronic lung disease, undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass, median sternotomy incision type and interposition of saphenous vein graft, or internal mammary artery or radial.	Not perform the surgical procedure according to the technique already specified, reoperations and / or associated procedures like approach valvular or carotid endarterectomy, present malignant ventricular arrhythmias, complexes ventricular premature beats, supraventricular tachycardia or sinus greater than 120 beats per minute, atrioventricular block of 2nd or 3rd degree, signs of low cardiac output or ventricular failure, hypotension, heart failure and recent myocardial infarction (less than 6 months), present chronic obstructive pulmonary disease, diabetes mellitus with documented diabetic neuropathy and/or presence of disease in the kidneys and liver, users of heart pacemaker, general impairment, weakness, fever, and associated neurological sequelae and difficulty understanding and/or adherence to study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-96h8bx	Walking training with body weight support system on mobile and fixed surfaces in children with cerebral palsy who have gait impaired.	Recruiting	Intervention	2013-09-19	<NULL>	<NULL>	252	Partial body weight support system in fixed and mobile surface for walking training in subjects with locomotor system impaired	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Cruzeiro do Sul	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-96h8bx	<NULL>	Children aged 4 to 10 years; Diagnosis of hemiplegic or diplegic cerebral palsy; No cognitive, visual and verbal impairment that can interfere with the performance of tasks;Be classified between levels II and IV of the Gross Motor Function Classification System (GMFCS) for Cerebral Palsy.	Have be submitted to surgical procedures in the last 12 months before the start of training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-7m2xdy	Study To Assess Whether Polypropylene Mesh In Surgery For Cystocele Is Safe And Has Favorable Outcome	Recruitment completed	Intervention	2013-09-19	<NULL>	<NULL>	253	Efficacy And Safety Study With Polipropilene Mesh (Nazca Tc) For The Treatment Of Anterior Vaginal Wall Prolapse	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Universidade Federal de São Carlos	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m2xdy	<NULL>	Not pregnant women; signs and symptoms of genital prolapse; no acute urinary or vaginal infection; no malignant disease; sign in the informed consent	previous surgery for pelvic organ prolapse with polipropylene mesh interposition; mentally disable; ot sign on the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-3ksb6x	Manual therapy and exercises applied to cervical spine in patients with temporomandibular disorders	Data analysis completed	Intervention	2013-09-22	<NULL>	<NULL>	254	Effect of a cervical rehabilitation protocol in clinical condition and mandibular function in patients with temporomandibular disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-10	Universidade Federal São Carlos - UFSCar	Universidade Federal São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-3ksb6x	<NULL>	Patients diagnosed with myogenic or mixed temporomandibular disorders	Patients diagnosed with arthrogenic or discogenic temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5668v4	Effect of Diet and Omega-3 Supplementation on Markers of Risk for Heart Disease in  Postmenopausal Women	Data analysis completed	Intervention	2013-10-04	<NULL>	<NULL>	255	Impact of Dietary Adequacy and Omega 3 Supplementation on the Metabolic and Inflammatory Markers of Cardiovascular Risk in Postmenopausal Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista  UNESP, Julio de Mesquita Filho	FAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5668v4	<NULL>	Women with: (1) date of last menstrual period for at least 12 months, (2) age between 45 and 65 years, (3) at least three criteria for the diagnosis of metabolic syndrome (waist circumference &gt; 88 cm; triglycerides &gt; 150 mg/dL; HDL cholesterol &lt; 50 mg/dL; blood pressure &gt; 130/85 mmHg or under therapy; fasting glucose &gt; 100 mg/dL or under therapy).	The exclusion criteria were: (1) presence of cardiovascular disease manifests current or previous, (2) use drugs that affect lipoprotein metabolism (hormone therapy, statins), (3) alcoholic or drogaditas; (4) story autoimmune diseases, (5) history of malignancy; (6) intolerance or food allergy to fish; (7) insulin-dependent diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4xdkq4	Changes in muscle strength in elderly women after Kabat based training	Data analysis completed	Intervention	2013-10-08	<NULL>	<NULL>	256	Analysis of change in muscle conditioning before and after Kabat Proprioceptive Neuromuscular Facilitation based training in a elderly population	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4xdkq4	<NULL>	Women, physically active, aged between 60 and 70 years, healthy, no history of surgery or chronic pathologies such as systemic arterial hypertension and diabetes.	Suffering from chronic diseases of any kind; history of surgery; sedentary, they do not agree with the terms of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-6jbpxc	Influence of education and home care in chronic muscle pain in the face	Not yet recruiting	Intervention	2013-10-16	<NULL>	<NULL>	257	Influence of education and self-care on pain and function related to chronic temporomandibular disorders: a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-10	UNESP - Universidade Estadual Paulista / Faculdade de Odontologia de Araraquara	UNESP - Universidade Estadual Paulista / Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-6jbpxc	<NULL>	"Female gender
Aged between 18 and 70 years old
Chronic pain related to temporomandibular disorder
Do not be in treatment for this painful condition
Do not be starting any treatment for any other painful condition fibromyalgia, back pain, neck pain or rheumatic changes. If a medication has been using for 3 months or more, may be included in the sample.
Be able to read and write.
Do not present  problems in cognitive abilities or communication."	"Presence of acute TMD.
If the individual is starting treatment for any painful condition as fibromyalgia, back pain, neck pain, or rheumatic diseases.
Presence of cognitive or communication difficulties."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3vjfr8	Prognostic indexes of reintubation	Data analysis completed	Observational	2013-10-16	<NULL>	<NULL>	258	Validation of combination of prognostic indexes for reintubation in adults and verification of its applicability in different clinical situations	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3vjfr8	<NULL>	"patients under mechanical ventilation
adults
intensive care unit 
considered able to be extubated"	"traqueotomized
without weaning criteria"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-7rjt4t	Brief Intervention for Alcohol Use and Domestic Violence Among Women	Recruitment completed	Intervention	2013-10-17	<NULL>	<NULL>	259	Patterns of Domestic Violence and Alcohol Use Among Women: Effectiveness of A Brief Intervention In A Household Setting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-16	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rjt4t	<NULL>	Women between 18 and 60 years old, enrolled previously in a household survey, who presented score equal to or higher than 8 in the AUDIT (high risk alcohol use)	Women with evident cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-5n4y2g	Cardiovascular Health Care Program – PROCARDIO-UFV	Recruiting	Intervention	2013-10-21	<NULL>	<NULL>	260	Use of Different Strategies in Nutritional Intervention in the Cardiovascular Health Care Program – PROCARDIO-UFV	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5n4y2g	<NULL>	Age higher 20 years old, diagnosed cardiovascular disease or occurence of risk factors: dyslipidemia, hypertension, diabetes or metabolic syndrome, to be a worker or dependents&apos;worker or students of Federal University of Viçosa	Do not want to participate of the study; To be not a worker or dependents&apos;worker or students of Federal University of Viçosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-42kz9z	Evaluation of acupuncture on the treatment of head,neck and shoulders pain.	Recruitment completed	Intervention	2013-10-24	<NULL>	<NULL>	261	Evaluation of acupuncture and electroacupuncture on the treatment of upper trapezius myofascial pain - a randomized double blinded placebo controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-18	Faculdade de Odontologia de Piracicaba/UNICAMP	FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-42kz9z	<NULL>	present at least one myofascial point at the upper trapezius muscle, local or referred pain at least for 6 months and body max index between 19 and 27 kg/m2	important body posture dysfunction, fibromialgy diagnose, cervical neurological dysfunction, systemic disease or that have received physical interventions for myofascial pain at the last month before the study, that present communication difficulties,constant use medication that can relief muscular pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-7ckpdd	Study of sleep quality, the strength of the lungs, the strength of the muscles of breathing, closing of the throat, nervous system and quality of life in patients with Myasthenia Gravis	Not yet recruiting	Observational	2013-10-30	<NULL>	<NULL>	262	Evaluation of sleep, lung function, respiratory muscle strength, respiratory mechanics, collapsibility of the upper airway, autonomic nervous activity, and quality of life in patients with Myasthenia Gravis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7ckpdd	<NULL>	Patients diagnosed with Myasthenia Gravis, clinically stable, of both genders, aged between 18 and 65 years, who agree to participate in this study by signing the Instrument of Consent.	Patients who making use of abusive alcohol and or drugs and which is not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-23kwzb	Effects of Therapeutic Currents in Health Subjects	Data analysis completed	Intervention	2013-10-30	<NULL>	<NULL>	263	Comparison of Sensorial Discomfort and Peak Torque During Neuromuscular Electric Stimulation With Medium and Low Frequency Currents	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-18	Univerdade Federal de São Carlos	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-23kwzb	<NULL>	Being female, healthy, physically active, aged between 18 and 30 years, body mass index (BMI) between 20 and 25 kg / m², with range of motion and knee function preserved, free from orthopedic diseases, pulmonary, cardiovascular, immune, and metabolic or chronic.	Age above 30 years. Male.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-4w2jc2	Evaluation of effect of probiotic in the treatment of cancer sores	Recruitment completed	Intervention	2013-10-30	<NULL>	<NULL>	264	Efficacy of the probiotic in the treatment of patients with recurrent aphthous stomatitis	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2011-01-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4w2jc2	<NULL>	Patients with a history of recurrent aphthous stomatitis (RAS) with age between 18 to 60 years, both genders; suffering from RAS for at least one year, with ulcers at least once a month; who had signed informed consent.	Patients with a history of EAR under age of 18 or over 60 years; chronic smokers or alcoholics ; pregnancy or it suspicion ; patients with current or previous malignancies ; undergoing chemotherapy or radiotherapy ; suspected or history of congenital or acquired immunodeficiency ; under suspected or history of Crohn&apos;s disease or other inflammatory bowel diseases ; suspected or history of periodic fever syndrome associated with aphthous stomatitis , pharyngitis and cervical adenitis ( PFAPA ) , Reiter&apos;s syndrome , or suspected Behcet&apos;s disease; suspected or history of any vitamin or nutritional deficiency , cyclic neutropenia , anemia  and autoimunes diseases , chronic use of drugs such as nonsteroidal anti esterioidais , immunosuppressants ( azathioprine , cyclosporine , corticosteroids , interferons ) , anxiolytics , antidepressants or nicorandil ; diseases such as renal failure , liver failure , hyperthyroidism or hypothyroidism , in the use of any type of food with probiotics and fiber supplements and antidiarrheal medications or laxatives regularly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-9gfmm5	Evaluation of the effect of two gingival treatments in the development of gingival disease in children with heart disease	Data analysis completed	Intervention	2013-10-30	<NULL>	<NULL>	265	Evaluation of the effect of two periodontal treatments in the development of periodontal periodontal disease in children with heart disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-29	Universidade Estadual do Oeste do Paraná - Unioeste	Universidade Estadual do Oeste do Paraná - Unioeste	https://ensaiosclinicos.gov.br/rg/RBR-9gfmm5	<NULL>	The children should have between 8-12 years of age with chronic periodontitis, with at least 2 sites with probing depth greater than 5 mm and clinical attachment level over 2 mm, bleeding on probing and gingival inflammation to clinical examination. The teeth should perform reasonably aligned, with a minimum of 20 teeth in the arch, with the clinical examination in the buccal, lingual / palatal, mesial and distal	Use of antibiotics and anti-inflammatories, steroids or no steroids in the month prior to the study; periodontal treatment in the previous 6 months, and those with any chronic inflammatory disease such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or Chron&apos;s disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-9kkv53	Sealing caries lesion as alternative for management in primary teeth	Terminated	Intervention	2013-12-09	<NULL>	<NULL>	266	Longitudinal evaluation of occlusal caries lesions sealed compared to conventional restorative treatment in primary teeth	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2010-01-15	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9kkv53	<NULL>	Healthy volunteers; between 4 and 9 years old; both genders; with one primary molar with occlusal carious lesion reaching dentine with an opening in enamel not wider than 3 mm diameter; radiographically the lesion should be in the outer half of dentine.	Patients who were not colaborators; restorations on the selected tooth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3xktv5	Auriculotherapy effectiveness in reducing smoking	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	267	Auriculotherapy effectiveness in reducing smoking	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade Federal de Alfenas	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3xktv5	<NULL>	"Possessing 18 years of age or older;
Being a smoker (daily make use of any quantity of cigarettes, including a);
Present level of carbon monoxide in exhaled air (COex) above 6 ppm (parts per million).
Having the desire to quit smoking;
Voluntarily participate in the study with available time to commit to sessions of auriculotherapy."	"Infection, inflammation or injury to the ear;
Make use of ear piercing (except earrings normal);
Make some treatment for tobacco, medicinal or not.
Pregnant."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-5xt9pw	Effect of physical training exercises performed at home with the help of videoaula in renal patients	Recruitment completed	Intervention	2013-12-09	<NULL>	<NULL>	268	Effect of physical training home associated with the use of technology in patients with end stage renal disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Universidade de Passo Fundo	Paulo Ricardo Moreira (Coord. da pesquisa no Hospital São Vicente de Paulo)	https://ensaiosclinicos.gov.br/rg/RBR-5xt9pw	<NULL>	Individuals aged 18 years or more; of both sexes; diagnosed with CRF and on kidney dialysis, who are not performing exercises frequently, having dvd player at home.	Patients unable to take exercise, without cognitive capacity, which prevents the understanding and implementation of the proposed exercises, which are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-6rzhnh	Defense mechanisms evaluation in abstinent smokers	Data analysis completed	Intervention	2013-12-18	<NULL>	<NULL>	269	Participation of Th1/Th2 cytokines and mucociliary clearance in current and abstinent smokers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	Departamento de Fisioterapia da Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6rzhnh	<NULL>	Smokers with at least 20 years of smoking; both sexes; apparently healthy; enrolled in the Smoking Cessation Programme from Faculty of Sciences and Technology of São Paulo State University	Diagnosis cystic fibrosis, bronchiectasis, immotile cilia syndrome, chronic obstructive pulmonary disease, smoking-related diseases, history of nasal surgery or trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8mf5x2	Clinical Trial comparative with and without use of Nimotuzumab for the treatment of Cervical Cancer with radiotherapy and Cisplatin	Not yet recruiting	Intervention	2014-01-15	<NULL>	<NULL>	270	A Phase III, Multicenter, Randomized, Two-arm Clinical Study: An Investigational Arm Containing Nimotuzumab in Combination with Radiation Therapy and Cisplatin, and A Control Arm with Radiation Therapy and Cisplatin for the Treatment of Stages IIb to IVa Uterine Cervical Carcinoma	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2014-01-02	Eurofarma Laboratórios S.A.	Eurofarma Laboratórios S.A.	https://ensaiosclinicos.gov.br/rg/RBR-8mf5x2	<NULL>	Be 18 years of age or older; have a histologically confirmed diagnosis of stage IIB to IVA squamous cell carcinoma, or adenocarcinoma, or cervical adenosquamous carcinoma, according to the IFGO system; life expectancy longer than 12 weeks; have measurable disease, according to the RECIST 1.1 criteria, or at least assessable by imaging and/or gynecological examination (imaging from up to six weeks prior to randomization will be accepted); indication for definitive treatment with chemotherapy and radiation therapy, according to the investigator’s opinion; performance status ? 2, according to the ECOG criteria; adequate bodily functions; have signed the informed consent form.	Involvement of para-aortic lymph nodes, by radiological and/or surgical staging, according to the investigator’s opinion; presence of severe co-morbidities, which –  according to the opinion of the investigator – will put the patient at a significantly higher risk or will impair compliance with the protocol; presence of neurological or psychiatric diseases or other significant conditions compromising compliance; known hypersensitivity or allergy to the study treatments; non-controlled hypercalcemia (&gt; 11.5 mg/dL, i.e., grade &gt; 1 according to CTCAE v4.02, of the American National Cancer Institute); known seropositivity to HIV; known and active hepatitis B or C; pregnant or lactating patients; patients – and their partners – refusing to use a proper contraceptive method during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-26qdtg	Effects of everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	Recruiting	Intervention	2014-01-16	<NULL>	<NULL>	271	Effects of Everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2012-05-09	Hospital das Clínicas da Faculdade de Medicina de Botucatu	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-26qdtg	<NULL>	The patient who agree to participate in the study, who have a consent form signed and meet the following criteria: age of 30 years or greater and being a recipient of de novo kidney transplant from a deceased donor or non-HLA identical living donor. At randomization time the patients needs to meet this criteria: creatinine clearance estimated by Cockroft-Gault formula of 40ml/min or greater and proteinuria of 800mg/day or less.	Patients will be excluded of the study if: with painel reactive antibody of 50% or higher, recipients of a second transplant with the first transplant loss for any immunological cause within the first year of transplantation, multi-organ recipient, ABO incompatible donor; non-beating heart donor; donor age of 5 yars or less and donor age of 65 years or higher. At the randomization  time, patients will be excluded if: they were on a rejection treatment, if they have history of Baff IIB or higher rejection insult, previous rejection resistant to corticosteroids, presence of subclinical rejection or severe inflammation on protocolar biopsy, presence of total blood cont leucocyte of 2500uL or less, neutrofiles of 1500uL or less, platelets of 75000uL or less, hemoglobin of 6,0g/L or less, liver disease or active infection, positive pregnancy test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8ttw64	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	272	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Instituto de Cardiologia Fundação Universitária de Cardiologia- IC/FUC	Número do Parecer: 400.879 - Comitê de Ética em Pesquisa do Instituto de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8ttw64	<NULL>	Children both genders aged 7-11 years whose parents or caregivers signed an informed consent form, reside in the state of Rio Grande do Sul and having overweight overweight or obese according to the criteria of the World Health Organization.	Children with neurological disorders that interfere with learning, cognitive deficits eg Disorder Attention Deficit Hyperactivity Disorder; contraindications for physical activity group and using drugs that interfere with the body weight or lipid profile, such as statins, ritonavir, furosemide hidrocloritiazida, propranolol, nadolol, prednisolone among others.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-9mndx8	Effect of the Pilates in elderly	Data analysis completed	Intervention	2014-02-03	<NULL>	<NULL>	273	Effect of the method pilates in flexibility, quality of life and level of pain in the elderly.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências- UNESP	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-9mndx8	<NULL>	Women over 60, who reported the presence of chronic musculoskeletal pain, continuous or essentially continuous with exacerbations for at least six months prior to the study.	Neurological symptoms, discrepancy between the lower limbs greater than two centimeters, ankylosing spondylitis, rheumatoid arthritis, herniated disk, tumor, infection, vertebral fracture, cauda equina syndrome, cognitive impairment and cardiovascular or dropouts during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-2t9t7q	Analysis of the effectiveness of acupuncture as a therapeutic procedure in older people with tinnitus.	Recruitment completed	Intervention	2014-02-03	<NULL>	<NULL>	274	Analysis of the effectiveness of acupuncture as a therapeutic procedure in older people with tinnitus: randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-23	Universidade Norte do Paraná	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2t9t7q	<NULL>	"Elderly individuals with complain of tinnitus of sensorineural origin;
Age of 60 years or more."	"Present active cardiovascular disease;
Possessing cardiac pacemaker;
Possessing metallic prostheses or implants;
Complain of tinnitus generated by the para-auditory system."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-222wkf	The role of vitamin D on the frequency of falls and postural balance in postmenopausal women	Recruitment completed	Intervention	2014-02-07	<NULL>	<NULL>	275	The role of vitamin D on the frequency of falls and postural balance in postmenopausal women	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2012-10-25	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-222wkf	<NULL>	Amenorrhea for at least 12 months; age between 50 and 75 years; history of falls in the past 12 months	"Neurological diseases with altered balance;disease musculoskeletal with deformity of the lower limbs; presence of cognitive impairment; visual impairment uncorrected; clinical symptoms of dizziness, tinnitus, hearing loss and plentitude ear; wasting syndrome; uncontrolled hypertension; postural hypotension; taking medications that alter the balance; alcoholic;morbid obesity; use of drugs that interfere with bone metabolism; use of pharmacological doses of Vitamin D; the presence of hypercalciuria or hyperparathyroidism;
renal failure or creatinine below 1.2 mg/dl; liver diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-8kqqxh	Evaluation Forms of Anestesia for Human Reproduction	Not yet recruiting	Intervention	2014-02-10	<NULL>	<NULL>	276	Comparative Study Between Two Anesthetic Techniques For Follicular Puncture Guided By Transvaginal Ultrasound	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Faculdade de Medicina do ABC	Centro de Reprodução Humana e Genética da Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8kqqxh	<NULL>	Women with the presence of at least one follicle bigger than 14 millimeters, to be punctured; Aged between 20 to 40 years old; with a diagnosis of infertility patients who attempted to spontaneous pregnancy for at least 12 months with regular sexual activity and without the use of contraceptives, however, failed to achieve pregnancy; Body Mass Index (BMI) between 20 and 30; Surgical risk by American Society of Anesthesiologists (ASA) 1 or 2.	Incomplete medical records; Carriers of chromosomal diseases; donor oocytes; Pathologies associeted with surgical risk ASA III, IV, V and VI; Presence of known allergy to anesthethic drugs used in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-2vsvs3	Evaluation of granular Brazil-nut in the treatment of hypertensive and dyslipidemic.	Recruiting	Intervention	2014-02-10	<NULL>	<NULL>	277	Effect of the supplementation with granular Brazil-nut in the microcirculation and biomarkers in hypertensive and dyslipidemics subjects.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital Universitário Clementino Fraga Filho	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-2vsvs3	<NULL>	Hypertensive and dyslipidemic patients between 20 and 100 years old.	Individuals with known food allergy or aversion to the Brazil nut;Pregnant women and nursing mothers,Be making use of dietary supplements containing antioxidant vitamins or minerals,Show untreated thyroid diseases and destabilized,Display chronic renal failure or liver disease, Being in substance use steroids,Show rheumatic heart disease or systemic collagen, Age up to 20 years and older than 100 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-6fmfr8	Ultrasound-guided ophthalmic anesthesia	Data analysis completed	Intervention	2014-02-26	<NULL>	<NULL>	278	Ultrasound-guided periconal blockade: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Faculdade de Medicina de Botucatu (FMB), UNESP	Instituto Benjamin Constant	https://ensaiosclinicos.gov.br/rg/RBR-6fmfr8	<NULL>	Cataract patients, both genders, aged between 18 and 95 years old, healthy or with mild or moderate systemic disease without functional limitation according to the American Society of Anesthesiologists I-II, respectively.	Patients with high myopia (axial length&gt; 26mm) and the presence of staphyloma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-4zdy9p	Effect of baru almond in coronary heart disease risk factors	Recruitment completed	Intervention	2014-03-19	<NULL>	<NULL>	279	Effec of baru almond in serum lipid and oxidative state in individuals with moderate hypercholesterolemia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-15	Faculdade de Nutrição - FANUT/UFG	Faculdade de Nutrição - FANUT/UFG	https://ensaiosclinicos.gov.br/rg/RBR-4zdy9p	<NULL>	Men and women alduts (19 - 60 years old); omnivores; BMI between 18.5 and 30 kilogram per meter squared; total cholesterol between 50-95 th percentile (NCEP - National Cholesterol Education Program): between 200 and 255 mg/dL for men and between 201 and 265 mg/dL for women,	Use of any nutritional intervention and/or drugs, such omega 3 or dietary fiber; vegetarians; presence of chronic diseases, such hypertension, diabetes, cardiovascular disease or cancer; chronic alcoholics (consumption more than 2 times a week); frequent consumption of nuts (more than 2 times a week); allergy of nuts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-6tx8y8	Primer orientation in the treatment of migraine.	Recruiting	Intervention	2014-03-21	<NULL>	<NULL>	280	Effect of additional guidance booklet to conventional therapy in reducing the frequency and intensity of migraine: a randomized controlled clinical study	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2013-08-01	Faculdade de Medicina de Ribeirão preto da Universidade de São Paulo	Maria Claudia Gonçalves	https://ensaiosclinicos.gov.br/rg/RBR-6tx8y8	<NULL>	200 subjects of both sexes, literate, aged between 18 and 65 years, with a diagnosis of migraine with or without aura, conducted by neurologists according to the criteria of the International Classification of Headache Disorders (2004) of the International Headache Society (IHS). Volunteers should have reported at least 2 attacks per month for at least one year, whether or not prophylactic drug treatment, regardless of the drug prescribed by the doctor and the existence or not of analgesic abuse	patients diagnosed with significant psychological disorders such as depressive disorders, bipolar disorder and schizophrenia, cognitive impairment, illiteracy or difficulty to understand or communicate in Portuguese, systemic diseases and chronic pain such as fibromyalgia and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-5h9b3c	Low-dose combined oral contraceptives use is associated to lower bone mass in adolescents over a one-year period	Recruitment completed	Intervention	2014-04-02	<NULL>	<NULL>	281	Bone mineral density in adolescents using combined oral contraceptives	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-10	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5h9b3c	<NULL>	healthy female volunteers; between 12 and 20 years old; who were post menarche and had regular menstrual cycles; attending the Adolescent Medicine Outpatient Clinic at Botucatu University Hospital from the São Paulo State University -UNESP; not using any type of hormonal contraceptive.	premature or low birth weight; prolonged steroid treatment; with diabetes mellitus, acute or chronic malnutrition, congenital or acquired bone diseases, gastrointestinal malabsorption, history of nephropathy, endocrinopathies; early or late puberty; chronic drug consumption; use of medication known to negatively affect bone metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-8tsrb7	Does the videogame training increases the power of the female pelvic floor muscles?	Recruitment completed	Intervention	2014-04-02	<NULL>	<NULL>	282	Does the Virtual Rehabilitation Training increases contractility of the female pelvic floor muscles?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-15	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8tsrb7	<NULL>	Women aged from 40 years.	Presence of urinary tract infection; having performed previously, pelvic floor muscles training supervised by a professional health; Carriers myopathies and diseases with known alteration of collagen; Carriers neurological abnormalities, cognitive disorders and physical limitations that preclude participation in the study; presence of dystopia of grade III or IV found by physical examination by Pelvic Organ Prolapse Quantification System - POP-Q.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-63s483	Effects of different types of hydration on the cardiovascular system	Recruitment completed	Intervention	2014-04-07	<NULL>	<NULL>	283	Hydration in endurance exercise: effects of different protocols on the variability of heart rate, cardiorespiratory parameters, heart rate recovery and reentry vagal	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-08	Universidade Federal de São Paulo (UNIFESP)	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-63s483	<NULL>	Healthy volunteers, male, aged between 18 and 30 years; practicing moderate physical activities according to the International Physical Activity Questionnaire - IPAQ	Smokers volunteers, use of medications that affect the autonomic activity of the heart such as beta-blockers and angiotensin-converting enzyme inhibitors; alcoholics; diagnosis of metabolic and/or endocrine known as a diabetes mellitus and dislipedemia example, that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-5ph2zw	Impact of exercise on the urinary control muscles in women with Multiple Sclerosis	Recruiting	Intervention	2014-04-08	<NULL>	<NULL>	284	Impact of a pelvic floor training program on the quality of life of women with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Mato Grosso do Sul	Gustavo Christofoletti	https://ensaiosclinicos.gov.br/rg/RBR-5ph2zw	<NULL>	Women diagnosed with Multiple Sclerosis;  age over 20 years; score on the Expanded Disability Status Scale (EDSS) lower or equal to 6.5; presence of symptoms of urinary dysfunction for at least six months.	Refusal to participate; exacerbation of symptoms  of Multiple Sclerosis during treatment; cognitive decline;  imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-9366qc	Evaluation of folinic acid supplementation, to prevent dysfunction of blood vessels in patients with HIV and HIV-HCV	Recruitment completed	Intervention	2014-04-25	<NULL>	<NULL>	285	Clinical Trial Randomized, Double Blind, Placebo Controlled, of folinic acid supplementation on Endothelial Function in Individuals Infected with HIV and HIV-HCV.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-20	Fabio Lopes Pedro	Fabio Lopes Pedro	https://ensaiosclinicos.gov.br/rg/RBR-9366qc	<NULL>	Monoinfected patients by with HIV; or HCV-HIV co-infected; using antiretroviral therapy; who signed an consent form.	history of diabetes mellitus; acute myocardial infarction; renal insufficiency (creatinine current&gt; 1.5); stroke; clinical signs and / or laboratory evidence of liver cirrhosis (ascites, hepatic encephalopathy present or recent upper gastrointestinal bleeding, esophageal varices present, liver ultrasound with signs suggestive of cirrhosis, biopsy Metavir F4); current pregnancy; recent use (last 30 days) of: statins, fibrates, hormone replacement therapy, sulfonamides (sulfamethoxazole, sulfadiazine), vitamin supplements, or similar of folinic acid and / or folic acid; Individuals with restriction or inability to understand and decide for their participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-4z5z3t	Effects of therapeutic ultrasound on the vascular response	Recruiting	Intervention	2014-04-28	<NULL>	<NULL>	286	Effects of therapeutic ultrasound of low intensity in endothelial function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-4z5z3t	<NULL>	Literate volunteers. Aged between 18 and 40 years old. Body mass index (BMI: kg/m2) less than 30. Have no symptoms of musculoskeletal disorders. Not making use of medication (except contraceptives), smoking and alcohol. Have no previous diagnosis of rheumatic diseases, cardiovascular, metabolic, neurological, oncological, haematological and immunological. Absence of psychiatric or cognitive problems.	Volunteers who performed high-intensity physical activity 72 hours before evaluations; presence of inflammatory response measured by the ultrasensitive PCR &gt;3mg/dL, fibrinogen &lt;200 or &gt;400mg/dL, leukocytosis &gt;11,000 x103/mm3, body temperature less than 38ºC, consumer beverages containing caffeine or alcohol, arterial diameter between &lt;2.5mm and &gt;5mm and endothelial dysfunction assessed by FMD (&lt;8%).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-36r3t5	Effect of elastic bandages on pain, swelling and strength in elderly subjects with knee osteoarthritis	Recruiting	Intervention	2014-04-29	<NULL>	<NULL>	287	Effect of kinesio taping on pain, swelling and strength in elderly subjects with knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-36r3t5	<NULL>	Volunteers of both gender, age over 60 years, presence of pain in knee (4/10 in visual analogue scale); joint stiffness of the knee at least six months for activities in the standing position; presence of joint pain during passive motion; intermittent swelling; radiographic joint degeneration.	Presence of systemic rheumatic disease; previous surgery of the lower limbs; some other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-4n2sxr	Quantity of injuries, heat stress and physiotherapy in triathlon athletes after competition of middle and long distance	Recruiting	Intervention	2014-04-29	<NULL>	<NULL>	288	Epidemiology of injuries, heat stress and physiotherapy in triathlon athletes after competition of middle and long distance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4n2sxr	<NULL>	Athletes aged between 18 and 55 years; of both gender; they must complete triathlon&apos;s competition of middle and long distance and they must go to the physiotherapy sector of the competition; with pain in the muscles of the quadriceps femoris.	Presence of excoriation in the thigh area; perform other intervention to change to the sensitivity as cryotherapy, analgesic or anesthetic on site assessment;  presence of neurological or musculoskeletal disease that interferes or contraindicate the procedures for intervention and/or measurement; metabolic and severe breathing disorders; cramps during the assessment procedures or intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-56brsc	Impact of specific physcail therapy treatment on the health of patients with Parkinson&apos;s disease	Recruiting	Intervention	2014-04-30	<NULL>	<NULL>	289	Effects of cognitive-motor rehabilitation on non-motor symptoms of patients with Parkinson&apos;s disease: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade Federal  de Mato Grosso do Sul	Universidade Federal  de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-56brsc	<NULL>	Volunteers of both gender, aged between 60 and 90 years, diagnosed with idiopathic Parkins&apos;s disease, with clinical profile indicating moderate impairment based on the Hoehn–Yarh scale and on the motor subscale of the Unified Parkinson&apos;s Disease Rating Scale	Patients with cognitive decline, those with movement disorders not compatible with a diagnosis of idiopathic Parkinson&apos;s disease (such as secondary Parkinsonism), subjects with congenital or acquired amaurosis and those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-7mhyzt	Implementation of an educational activity in pregnant women on healthy eating	Recruitment completed	Intervention	2014-05-05	<NULL>	<NULL>	290	Effect of an educational intervention in pregnancy to healthy eating with regional food	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-12-16	Centro de Ciências da Saúde da Universidade Federal de Pernambuco- CCS /UFPE	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7mhyzt	<NULL>	Pregnant volunteers ente 18- 42 years, be performing prenatal consultation at low risk in the Health Unit Family and owning landline or cell phone.	Gestation above 36 weeks of pregnancy, Gestational Diabetes Mellitus, Gestational Hypertension, pregnancy termination and the difficulty to understand the questions and the questionnaire or educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-23nf3s	Effect of group vaginal muscle training in  post-menopausal women	Data analysis completed	Intervention	2014-05-07	<NULL>	<NULL>	291	Effect of a group pelvic floor muscle training in climateric and post-menopausal  women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-14	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-23nf3s	<NULL>	Post-menopausal women  for at least 5 years; with complaints from urogynecological symptoms; participants of Physical Activity in Congonhal&apos;s City.	women with vaginal or urinary infections; pelvic cancer; uncontrolled metabolic disorders (hypertension and diabetes); cognitive, psychiatric or neurological disorder; chronic vaginal pain; inability to contract the pelvic floor muscles (PFM); pelvic organ prolapse stage IV according to the Pelvic Organ Prolapse Quantification System (POP-Q) and severe heart disease , who added up to four volunteers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-9yvx59	The effect of elastic bandage in patients with osteoarthritis of the knee	Recruiting	Intervention	2014-05-09	<NULL>	<NULL>	292	The effectiveness of taping in patients with osteoarthritis of the knee - randomized clinical trial: pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yvx59	<NULL>	adult patients referred AACD - Lar Escola São Francisco diagnosed with moderate knee osteoarthritis and agree to participate in the study according to the term informed consent	patients with rheumatic diseases associated orthopedic surgery of the lower limbs prior injections of steroids in the past six months, obesity (BMI&gt; 35), allergy to components of physiotherapy those who underwent banding in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-9g4yp2	Bioelectrical impendance analysis parameters evaluation as severity markers in patients admitted in intensive care unit.	Recruiting	Observational	2013-12-10	<NULL>	<NULL>	293	Bioelectrical impendance analysis parameters evaluation as severity biomarkers in the critically ill patient	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-15	Instituto Fernandes Figueira - Fundação Oswaldo Cruz	Vice-presidência de pesquisa e laboratórios de referência - Programa de desenvolvimento tecnológico em saúde pública (PDTSP)	https://ensaiosclinicos.gov.br/rg/RBR-9g4yp2	<NULL>	All patients aged 1 month to 6 years-old admitted to the pediatric intensive care unit that do not presented on admission with the outcomes studied (multiple organs dysfunction &gt; or equal 4 or septic shock).	Children weighing less than 3kg on admission in the pediatric intensive care unit; impossibility to perform bioimpedance measurement in the first 24h of hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-85693t	Association between the fall of the bladder or uterus and postural balance in elderly women	Recruiting	Observational	2014-05-13	<NULL>	<NULL>	294	Association between genital prolapse and postural balance in elderly women	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Raquel Henriques Jácomo	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-85693t	<NULL>	Women aged over 60 years old  and less than or equal to 80 years old.	Respiratory disorders, surgeries of the spine, abdomen, and pelvic floor central nervous system, brain tumors, neurological disorders, vestibular and limbic, central and peripheral degenerative diseases, trauma, clinical symptoms such as dizziness, tinnitus, hearing loss, ear fullness, postural hypotension, medicines that change the balance, uncontrolled diabetes mellitus, pelvic floor rehabilitation in the last year, visual impairment or patients with corrective lenses that did not follow the last 2 years, bone densitometry showing osteoporosis in past 3 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-8d67bt	Effect of Balance Training on Muscle Electrical Activity in Subjects with Functional Chronic Instability	Recruitment completed	Intervention	2013-09-26	<NULL>	<NULL>	295	Strategies postural reaction in healthy subjects and with a deficit in motor control underwent postural disturbances	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade do Estado de Santa Catarina	Josilene Souza Conceição (Laboratório de Controle Motor - Universidade do Estado de Santa Catarina)	https://ensaiosclinicos.gov.br/rg/RBR-8d67bt	<NULL>	aged 18 to 30 years of age; history of two or more ankle sprains, with at least a sprain in the last six months; sensation of ankle instability, ie, the feeling that the ankle &quot;out of place&quot; during functional activities (work, leisure and / or sport); and score below 28 on the validated Portuguese-Brazil version of Cumberland Ankle Instability Tool.	acute signs of inflammation (pain, heat, redness, swelling) at the ankle; and history of fractures, rheumatic problems, neurological, or any other disease in the lower limbs that could impair the performance of the tasks proposed by the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-39dz5v	The effect of electrical stimulation for the treatment of overactive bladder in elderly women	Recruiting	Intervention	2014-05-22	<NULL>	<NULL>	296	Motor and sensitive response after posterior tibial nerve stimulation in elderly women with overactive bladder syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-15	Faculdade de Ceilândia - FCE	Centro de Saúde 04 de Ceilândia - DF	https://ensaiosclinicos.gov.br/rg/RBR-39dz5v	<NULL>	Females aged 60 years, complaining of overactive bladder.	Women are excluded elderly who use pacemakers and metal implants in the region of the right ankle, being contraindications of electrotherapy, patients submit UTI by urine culture or have pain when urinating and/or suprapubic pain (interstitial cystitis), presenting with hematuria sterile urine (suspicion of carcinoma in situ of the bladder), women who use drugs to treat overactive bladder in the past six months and women with a neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7nynr7	Effect of skin-to-skin compared to the sweet solution for pain relief in newborns who require repeated blood collection.	Recruiting	Intervention	2014-05-28	<NULL>	<NULL>	297	"Effect of skin-to-skin compared to sucrose for pain relief in infants undergoing repeated painful procedures:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-06	Escola de Enfermagem de Ribeirão Preto-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nynr7	<NULL>	Inclusion criteria: infants with gestational age greater than or equal to 36 weeks, which present Apgar score&gt; 7 at 5 minutes and clinical stability with maintaining physiological parameters in the normal range, ie, heart rate between 120 to 160 beats per minute (bpm). Mothers whose children are randomly assigned as skin to skin contact should be in physical and emotional conditions to breastfeed.	Exclusion criteria: infants who had birth trauma (fractures, skin lesions, soft tissue injuries cortocontusos, adiponecrose, bleeding from the sternocleidomastoid, brachial palsy, facial paresis, trauma of the sternocleidomastoid, intracranial hemorrhage, visceral rupture, bilateral paralysis of vocal cords, brachial palsy, facial palsy, spinal trauma and spinal cord and diaphragm paralysis), congenital malformations, difficulty swallowing, use of opioids in preterm and/or the mother less than six hours, presence of severe intraventricular hemorrhage or subsequent periventricular and contraindications of breastfeeding .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-6tnw2b	Evaluation of G-CSF treatment of patients with chagasic cardiomyopathy.	Not yet recruiting	Intervention	2014-05-28	<NULL>	<NULL>	298	Phase II clinical trial, prospective, double-blind, randomized, placebo-controlled trial for the evaluation of G-CSF in patients with chronic Chagas cardiomyopathy	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-01-02	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6tnw2b	<NULL>	Diagnosis of Chagas&apos; disease confirmed by two serological tests with different methodologies; Diagnosis of Chagas&apos; cardiomyopathy in functional classes II, III and NYHA IV heart failure; Availability and willingness to participate, given the schedule of the study; Agreement and signing the consent form.	"-Acute systemic infections; Solid Malignancies, myelodysplasia, acute myeloid leukemia or chronic, confirmed by imaging studies or past medical history; Valvular with hemodynamic consequences; 
Autoimmune, pulmonary, or degenerative diseases, confirmed by imaging studies or past medical history; Renal dysfunction, severe liver or thyroid, confirmed by imaging studies or past medical history; 
Pregnancy (confirmed by examination of ? HCG) or lactation; Known hypersensitivity to G-CSF or to other components of the formula and / or hypersensitivity to proteins derived from E. coli."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-5tdnbr	Effects of a health education program for patients with fibromyalgia	Data analysis completed	Intervention	2014-05-29	<NULL>	<NULL>	299	The impact of a health education program on neuroimmune and behavioral aspects of fibromyalgia patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Universidade Federal de Minas Gerais - UFMG	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-5tdnbr	<NULL>	Female gender; aged between 18 and 60 years; fibromyalgia diagnosis confirmed by a medical specialist	Less than 18 years, over 60 years old; modification in the pharmacologic treatment in the last three months; chronic inflammatory condition associated; autoimmune disease associated; history or presence of psychiatric disorders, infectious diseases, use of anti-inflammatory, antiallergic or antibiotic drugs in the last three months, pregnant women, lactating, participation in lower 80% of the classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7fyc7g	Evaluation of Maternal Training and Auxiliary Methods for Improving Toothbrushing on Babies	Data analysis completed	Intervention	2014-05-29	<NULL>	<NULL>	300	Evaluation of Mothers Training and Auxiliary Methods on Babies Toothbrushing Effectiveness	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Centro Universitário de Maringá	Bitufo Montagem e Comércio de Escovas Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7fyc7g	<NULL>	Babies presenting at least four deciduous teeth in the mouth, with at least half of the crown exposed; Babies free from tooth decay	Infants presenting carious lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-8h8x88	Intervention program for physical activity and consumption of fruits and vegetables in college	Recruitment completed	Intervention	2014-06-02	<NULL>	<NULL>	301	Impact of an intervention to increase physical activity levels and frequency of dietary intake of fruits and vegetables in college students: a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-19	Universidade Federal Rural de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8h8x88	<NULL>	Student of UFRPE; 18 - 24 years; regularly enrolled at headquarters.	Be carrying some kind of physical or mental disability; being in pregnancy, have health problems that would prohibit the practice of physical activity; do not have e-mail, be in academic exchanges (Brazilian or foreign)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-38nkj6	Effect of strength training in older depressed	Data analysis completed	Intervention	2014-06-10	<NULL>	<NULL>	302	Effect of strength training in older depressed	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Instituto de Neurologia Deolindo Couto	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-38nkj6	<NULL>	Right-handed; sedentary for more than three months; performing more than one month pharmacological treatment; clinical diagnosis using the criteria of the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).	Score over 18 points on the Hamilton Depression Scale; Score under 24 points in the Mini - Mental State Examination; Psychiatric comorbidities; neurodegenerative disease; severe cardiovascular disease; illiteracy; poor mobility; balance disorders; visual and / or auditory sharp.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-63kf95	Effects of a program of exercises with increasing weight for individuals with coronary artery disease	Recruiting	Intervention	2014-06-10	<NULL>	<NULL>	303	Effects of a resistance physical exercise program based on determination of anaerobic threshold in increasing resistance testing in patients with coronary artery disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-63kf95	<NULL>	Mens with aged between 50 and 82 y,with a clinical diagnosis of coronary artery disease, with at least 12 months after the acute event or 12 months after surgical or percutaneous revascularization, nonsmoking, non-alcoholic, non-users of drugs that cause addiction, presence of clinical stability, absence of acute exacerbations of the disease, anaemias in general, electrolyte disturbances and / or uncompensated metabolic, absence of permanent pacemaker or defibrillator implants or valve, absence of respiratory disorders, signs of ischemia or ST segment depression, complex arrhythmias, left ventricular dysfunction, and absence of neurological, neuromuscular, musculoskeletal and osteoarticular disabling, controlled blood pressure and level of understanding that does not prevent the implementation the proposed protocol.	Smokers, women, people with impaired muscle and bone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-97bp3c	Quality of Life in Patients who underwent radiotherapy	Recruitment completed	Intervention	2014-06-10	<NULL>	<NULL>	304	Quality of Life in Patients undergoing Radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Hospital do Câncer de Muriaé	Rhayssa Espósito	https://ensaiosclinicos.gov.br/rg/RBR-97bp3c	<NULL>	Cancer patients undergoing radiation treatment, both genders, aged 30 to 80 years.	Patients with motor change that prevented them from practicing the activities planned; severe to moderate anemia, bone metastases, severe thrombocytopenia, diabetes, severe heart disease, severe lung disease, with active infections; oxygen saturation less than or equal to 80% in the walk test 6 minutes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-64cw3x	Comparative analysis of the strength of the muscles of the vagina in women who know and do not know about the genital region	Recruitment completed	Intervention	2014-06-24	<NULL>	<NULL>	305	Comparative analysis of the function of the pelvic floor muscles in women with and without knowledge about genital anatomy	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2010-09-01	Raquel Henriques Jácomo	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-64cw3x	<NULL>	Women amenorrheic for at least 12 months	Dyspareunia; latex allergy; narrow vaginal opening; history of neurological disorders, severe obesity, signs and symptoms of urinary tract infection or vaginal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-943kwq	Comparing different techniques that may help epilepsy patients take their medicines	Recruitment completed	Intervention	2014-06-26	<NULL>	<NULL>	306	Compliance to drug therapy of Epilepsy patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-02-01	Escola de Enfermagem da Universidade de São Paulo	Cristina Helena Costanti Settervall	https://ensaiosclinicos.gov.br/rg/RBR-943kwq	<NULL>	Patients, from both genders, aged between 18 and 100 years-old, diagnosed with epilepsy in ambulatory care for over one year, with at least four years of school, independent in daily life activities, without mental and psychic disabilities, presenting  medium, or low adherence by the Morisky test.	Patients with medical prescription  with weekly or daily increase or removal of  anti-epileptic drugs,  including Carbamazepine, phenytoin, phenobarbital and valproate sodium; those that already use the resources tested in this trial to enhance compliance and with other chronic diseases in continuous  drug treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-8d3sp7	The effect of meditation in reducing anxiety of individuals at the stage of weight loss maintenance	Recruiting	Intervention	2014-07-07	<NULL>	<NULL>	307	Efficacy of Healing Meditation in reducing anxiety of individuals at the stage of weight loss maintenance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-02	Escola Bahiana de Medicina e Saúde Pública - EBMSP	Escola Bahiana de Medicina e Saúde Pública - EBMSP	https://ensaiosclinicos.gov.br/rg/RBR-8d3sp7	<NULL>	Be over 18 years of age; take part in the slimming program of Centro Terapeutico Máximo Ravenna in the city of Salvador (Brazil); be at the stage of weight loss maintenance.	Individuals with diagnosis of psychosis; individuals who do not accept participation in the study; those who do not sign the Term of Free and Informed Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-3rndh6	Electrotherapy in the treatment of pain during intercourse and assessment of the outcomes on the quality of life and sexuality of women with deep endometriosis	Recruiting	Intervention	2014-07-07	<NULL>	<NULL>	308	Transcutaneous Electrical Nerve Stimulation (TENS) in the treatment of deep dyspareunia  and assessment of the impact on the quality of life and sexuality of women with deep endometriosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-25	Ticiana Aparecida Alves de Mira	Ticiana Aparecida Alves de Mira	https://ensaiosclinicos.gov.br/rg/RBR-3rndh6	<NULL>	Sexually active women. Women in menacme. Diagnosis of endometriosis estages III, IV and/or of the rectovaginal septum. Deep dyspareunia.	Decreased skin sensitivity preventing the perception of the electric stimulus. Pregnant women. Pacemaker users. Hypersensitivity (allergic reactions to the gel or electrode). Epilepsy. Heart disease (arrhythmia). Osteosynthesis at the application site. Open sores. Malignant tumors. Acute inflammatory disease. Other associated gynecological pathologies. Cognitive disabilities that prevente the understanding of the use of the tools and/or conventional electrotherapeutic treatment or do not understand instructions for the use of the self-applied TENS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-78bq5x	Preventive measures and therapies for back pains	Recruitment completed	Intervention	2014-07-08	<NULL>	<NULL>	309	Preventive measures and non-invasive therapies for back pains	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Maria das Graças Rodrigues de Araújo	Isabela Franco Cavalcanti	https://ensaiosclinicos.gov.br/rg/RBR-78bq5x	<NULL>	Volunteers, both genders, aged 18 to 35 years, with pain for more than six weeks of non-specific origin in the neck and/or low back	Patients under the influence of other postural treatment or had breaks between GPR sessions bigger than 120 hours; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7jd2mm	Assessment of measures to improve sleep and quality of life of patients with heart failure	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	310	Efficacy of sleep hygiene and phototherapy in sleep and quality of life measures of patients with heart failure - a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-7jd2mm	<NULL>	Heart failure functional class I, II or III; have an active telephone contact; Do no pharmacological / non-pharmacological treatment for sleep improvement.	Cognitive impairment; total score in the Pittsburg Sleep Quality Index (PSQI) &lt; or equal to 5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-3r4h5s	Effect of exercise orientations in the posture and plantar pressure distribution in children and adolescents with cystic fibrosis	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	311	Effect of exercise orientations in the posture and plantar pressure distribution in children and adolescents with cystic fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3r4h5s	<NULL>	Individuals with a diagnosis of cystic fibrosis, aged six to twenty years, clinically stable disease and regular follow-up at the cystic fibrosis outpatient clinic.	Children and adolescents with comprehension deficits and/or who present arms/legs problems that would make it impossible to perform the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-2nwk89	Restoration of teeth with different ways of insertion and protection of restorative material	Data analysis completed	Intervention	2014-07-09	<NULL>	<NULL>	312	Longevity of ART restorations in proximal cavities using different techniques of insertion and superficial protection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-20	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2nwk89	<NULL>	Healthy volunteers; both genders; between 6 and 7 years of age; clinically presenting proximal caries lesion; lesion accessible to manual instruments used in atraumatic restorative treatment	Non-cooperative patients; restorations on the selected tooth; presence of fistula or abscess near the tooth selected to the research; presence of pulp exposure or mobility in the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-386qsg	Influence of positive airway pressure in the range of reduced pressure after exercise in hypertensive Patients with Obstructive Sleep Apnea	Recruiting	Intervention	2014-07-09	<NULL>	<NULL>	313	Influence of positive airway pressure in the magnitude post-exercise hipotension in hypertensive patients with obstructive sleep apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-05	José Heriston de Morais LIma	José Heriston de Morais LIma	https://ensaiosclinicos.gov.br/rg/RBR-386qsg	<NULL>	Sleep Apnea diagnosis, both genders, is between stage 1 and stage 3 hypertension; Being classified as Insufficiently active by Physical Activity Questionnaire; present classification in moderate to severe polysomnography; owning between 20 and 80 years, no history of previous lung disease, not present muscle damage, joint or bone that may compromise the partial or complete execution of any proposed exercise	Be classified as active in international physical activity questionnaire; presence of chronic lung disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7ptrb5	Effect of different types of exercise on postural balance in elderly women	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	314	Effects of different exercise programs on physical activity variables and physical  functional and psychological fitness of elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7ptrb5	<NULL>	Physically independent; participate voluntarily in the study.	Diagnostics neurological pathologies, skeletal muscle or any mental disorder that interferes interventions and tests; surgery in the locomotor system;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-4qsf57	Study of cardiac and metabolic control in women with polycystic ovary syndrome	Data analysis completed	Intervention	2014-07-14	<NULL>	<NULL>	315	Correlation study of the adaptations into cardiac autonomic modulation and metabolic parameters in women with polycystic ovary syndrome submitted to aerobic training	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-05	Fundação de Amparo à Pesquisa do Estado de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qsf57	<NULL>	Women aged between 18 and 40 healthy years and diagnosed with polycystic ovarian syndrome belonging to the outpatient clinic of Gynecology and Obstetrics of the University were not engaged in regular physical activity (least 2 times per week)	Exclusion criteria: women in use of contraceptives or other drug treatment, smoker (regular consumption of cigarettes or tobacco-derived.); alcoholic (physical and psychological dependence on alcohol); who had mental disorders that hindered the understanding and execution of tests; disabling musculoskeletal disorders (osteoporosis, fractures unconsolidated, muscular dystrophy, low back pain) and cardiovascular disease (myocardial infarction, heart failure, arrhythmias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4w6v2c	Evaluation of the Impact of neuromodulators on urinary, intestinal and sexual functions and on spasticity in spinal cord injured individuals	Not yet recruiting	Intervention	2014-07-14	<NULL>	<NULL>	316	Impact of lumbosacral plexus stimulation by means of laparoscopically implanted eletrodes on urinary, intestinal and vasomotor functions and on lower limb and pelvic floor spasticity and sleep quality in spinal cord injured individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Hospital São Paulo - Hospital Universitário da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4w6v2c	<NULL>	Individuals aging 18 to 60 years, with partial or complete spinal cord injury ASIA (American Spinal Injury Association) score A or B, in clean intermitent self-catheterization and/or with urinary incontinence and neurologically stable for more than one year.	"Subjects with the following characteristics will be excluded:  urodynamic bladder atonia; suspicion of vesicoureteral reflux prior to the spinal cord injury;	Diabetes Mellitus, compensated or not;	congenital or acquired immunodeficiency; known or suspected malignancy; history of rectossigmoidectomy, colectomy, or other gastrointestinal surgeries that can cause changes in bowel habits, stool anal continence or function; history of surgical treatment of uterovaginal prolapse, urinary incontinence, bladder augmentation procedures or other procedures associated with dysfunctional voiding (urethrotomy etc.); history of prostatectomy, transurethral resection of the prostate or prostatic other invasive procedures except biopsy; history of central or peripheral procedures neuroablative as rizotomy, cordotomy etc.;	uterovaginal prolapse, rectal or urethral;	cystostomy; anal or urethral stenosis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-38p23s	Psychological treatment for obese adolescents and their effects on social interaction and body mass index	Data analysis completed	Intervention	2014-07-18	<NULL>	<NULL>	317	"Multifocal intervention in obese adolescents: social competence, 
behavior problems, academic performance and weight reduction"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-18	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-38p23s	<NULL>	Both mass index above than the 95th percentile for age featuring obese according to the curves of the Center for Disease Control and Prevention (CDC, 2000); between 10 and 19 years old; willingness to participate in all program activities.	Psychological disorders; use of medications that could interfere in the variables; physical difficulties that impeded the development of all activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-22y7p9	Effect Of Muscle Strengthening on The Upper Limb Motor Recovery After Stroke	Data analysis completed	Intervention	2013-03-07	<NULL>	<NULL>	318	Effects of Functional and Analytical Strength Training on Upper-Extremity Motor and Functional Recovery After Stroke: a Randomized, Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Hospital Mãe de Deus	https://ensaiosclinicos.gov.br/rg/RBR-22y7p9	<NULL>	six months to five years since the onset of a unilateral stroke; ability to comprehend simple instructions (Mini-Mental State Examination with a minimum score of 20); no pain, contractures, or severe weakness in shoulder flexion muscles (&lt; 3 in the Manual Muscular Testing); and no upper-limb rehabilitation during this research.	other neurological, neuromuscular, or orthopedic disease; severe comorbidity diseases; or severe increase of upper extremity muscular tone(&gt; 3 points according to the modified Ashworth scale).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8dmcnj	Evaluation of the effects of the meditation practices on attention and mood of adults with attention deficit hyperactivity disorder	Data analysis completed	Intervention	2014-07-29	<NULL>	<NULL>	319	Evaluation of the effects of the mindulness meditation practices on cognition of adults with attention deficit hyperactivity disorder	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-8dmcnj	<NULL>	Individuals of both sexes, aged between 18 and 40 years, which have Portuguese as their first language, with high school education, normal vision or corrected to normal and normal hearing. The patients with ADHD are diagnosed by their doctors, they should be taking stable doses of methylphenidate (for at least a month) for their disorder as prescribed by their doctors.	The volunteers with neurological and psychiatric disorders such as psychosis, obsessive-compulsive disorder or Tourette&apos;s syndrome, and volunteers with prior experience with meditation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8jjhds	Workplace physical exercise program for  painful symptoms control in nursing personnel.	Recruitment completed	Intervention	2012-01-09	<NULL>	<NULL>	320	Exercise program for musculoskeletal symptoms prevention in nursing personnel of Hospital Santa Casa de Misericórdia of São Carlos.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8jjhds	<NULL>	active workers of nursing staff regularly registered at hospital Santa Casa de Misericórdia de São Carlos, older than 18 years old of both gender.	pregancy, presence of cardiovascular disease or methabolic disease, previous cardiac surgery, heart failure, hipertension, diabetes, hyperthyroidism, progressiva root neurologic alterations, spine inflamatory diseases, previous spine surgery and other chronic diseases which could contribute for musculoskeletal pain symptoms as fibromyalgia, kidney or gynecological alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-85vmkx	Changes in functional exercise functional capacity, body composition and quality of life of menopausal women	Recruitment completed	Intervention	2014-07-30	<NULL>	<NULL>	321	Changes of a physical activity program based on the protocol of functional training on functional abilities, body composition and quality of life of menopausal women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-10	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-85vmkx	<NULL>	Female volunteers, aged between 45 and 65 years; present in the menopausal period without menstruation for 1 year or more; possess a medical certificate to perform the tests required and participate in the training program	Present physical limitations or any health problems that prevent the implementation of the evaluation or bodily practices, accumulate three consecutive unexcused absences or 4 unexcused absences during the month of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-55y665	Treatment program for changes in posture	Data analysis completed	Intervention	2014-08-04	<NULL>	<NULL>	322	Rehabilitation program of postural deviations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-24	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-55y665	<NULL>	Able participants performing physical activity, of both genders aged 11 to 28 years, medical referral and the presence of greater than 10, confirmed by measurement of the Cobb angle on colonography scoliosis, featuring structural curves or changes in kyphosis and lordosis and Statement of Consent signed by parents or guardians.	Use of prostheses and / or orthoses, surgeries of the spine, presence of scoliosis etiology of idiopathic not, pregnancy, difference in leg length greater than 1,5 cm thus determining a cause of scoliosis is not idiopathic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-57cr2r	Study of the Effects of Stretching and Muscle Strengthening on Pain, Function, Balance and Muscle Strength in Patients with Heel Pain	Recruitment completed	Intervention	2014-08-12	<NULL>	<NULL>	323	Study of Balance, Posture Control and Muscle Strength in Patients with Plantar Fasciitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-57cr2r	<NULL>	"Plantar fasciitis;
age between 18 and 60."	Report of previous surgery and trauma in the lower limbs; discrepancy greater than 1.25 centimeters (cm) between the lower limbs; having performed strengthening of the muscles of the ankle and hip, and physiotherapeutic intervention in the lower limbs within the last six months; diagnosis of fibromyalgia, neurological, musculoskeletal or systemic order disease that may predispose heel pain and decreased muscle strength.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-9mtnvr	Influence of gymnastics classes on the development of balance control in elderly	Not yet recruiting	Intervention	2014-08-13	<NULL>	<NULL>	324	Gymnastics for All in postural balance in noninstitutionalized elderly: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-18	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9mtnvr	<NULL>	60-year and older age for both men and women, noninstitucionalized. 10 m of free walking without any auxiliary device. Low cardiovascular risk. Medical permission for participation in the study	Diagnosed psychiatric disease. Gait and balance dysfuntioc (Parkinson, Multiple Sclerosis,  stroke sequel, etc.). Use of meclizine hydrochloride. Severe respiratory insufficiency. Severe coronar arterial disease. Severe renal insufficiency. Severe hepatic insufficiency. Severe osteoporosis. With articular prosthesis and osteosynthesis material. Arterial pressure imbalance.  Dyslipidemc patients. Visual deficiency.  Uncontrolled diabetes. Labyrinthitis.  Minimental  score smaller than 24 points. Regular participation in an exercise program in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8wt2fy	Comparison of Two Types of General Anesthesia, Venous versus Inhalatory, regarding the Risk of Renal Injury after Videolaparoscopic Obesity Surgery	Data analysis completed	Intervention	2014-08-13	<NULL>	<NULL>	325	Efficacy of Total Intravenous Anesthesia (TIVA) in blocking Perioperative Elevation of NGAL in Laparoscopic Bariatric Surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2010-10-01	Adriano Teixeira Fernandes	Norma Sueli Pinheiro Módolo	https://ensaiosclinicos.gov.br/rg/RBR-8wt2fy	<NULL>	morbidly obese patients, scheduled for video laparoscopic bariatric surgery; both gender; age between 18 and 65 year.	volunteers with lung disease; heart failure; renal failure; cancer of any etiology; patients on chronic corticosteroid use; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2xx2z4	Effect of an intervention program for nutrition education and physical activity in the prevention of obesity in schoolchildren	Terminated	Intervention	2014-08-14	<NULL>	<NULL>	326	Effect of an intervention program with nutrition education and physical activity in the prevention of obesity in school children: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-10	Hospital de Clínicas de Porto Alegre (HCPA) da Universidade Federal do Rio Grande do Sul	Programa de pós-graduação em saúde da criança e do adolescente da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2xx2z4	<NULL>	Students of both sexes, who are regularly enrolled and regulars from first to fourth year of elementary school in the afternoon of the schools in the city of Porto Alegre-RS.	Students with disabilities to perform the anthropometric measures and special needs . In addition to the students who did not agree to undergo anthropometric measures and participation in the intervention program .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4pc22n	Acute effects of smoker&apos;s lung defense mechanism	Data analysis completed	Intervention	2014-08-18	<NULL>	<NULL>	327	Acute response of smoker&apos;s mucociliary clearance exposed to moderate aerobic exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-21	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; - Faculdade de Ciências e Tecnologia	"Departamento de Fisioterapia da Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Faculdade de Ciências e Tecnologia"	https://ensaiosclinicos.gov.br/rg/RBR-4pc22n	<NULL>	Subjects between 30 and 50 years old, both genders, with normal lung function attested by spirometry and absence of illnesses that interfere with exercise performance or autonomic modulation (eg, cerebrovascular, cardiac, orthopedic, rheumatic or metabolic disease, diabetes, alcoholism).	Not comprehension or non-cooperation on the procedures and methods of research; non-attendance at one of the days of the experimental protocol; subjects with lung disease diagnosed, history of surgery or nasal trauma, nasal septal deviation or inflammation of the upper airways observed in clinical evaluation during the interview and experimental protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-7376mq	The Impact of supplementation with L-carnitine in patients with heart disease undergoing cardiac surgery	Recruitment completed	Intervention	2014-08-19	<NULL>	<NULL>	328	The impact of supplementation with L-carnitine on left ventricular remodeling in patients with ischemic heart failure undergoing coronary artery bypass grafting	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-7376mq	<NULL>	Adults; lucid, oriented, both genders; greater than or equal to 18 years, less than or equal to 80 years, diagnosed with heart failure of ischemic etiology, NYHA functional class II and III; require coronary artery bypass grafting.	Renal dysfunction, hepatic dysfunction; disabsortive Syndromes; tumors, use of intra-aortic balloon; stroke, dysphagia, dialysis, sepsis, hemodynamic shock.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-86vp8x	Effects of Pilates in patients with cystic fibrosis	Data analysis completed	Intervention	2014-08-22	<NULL>	<NULL>	329	Analysis of the effects of pilates method associated with respiratory physiotherapy in patients with cystic fibrosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-86vp8x	<NULL>	Patients between 7 and 20 months of age, both genders, diagnosed with Cystic Fibrosis; presenting forced expiratory volume in one minute (FEV1) above 30% of predicted; with availability to attend the sessions of care.	Patients enrolled in a program of physical activity; presenting Cor Pulmonale severe; presenting twenty-five percent or more absences in the attendance sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2vtsmv	Functional electrical stimulation on shoulder dislocation of individuals with stroke.	Recruitment completed	Intervention	2014-08-24	<NULL>	<NULL>	330	Functional electrical stimulation for shoulder subluxation after chronic stroke (AVE)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2vtsmv	<NULL>	Patient with a history of ischemic stroke or hemorrhagic for over a year; both genders; aged between 40 and 70 years; presence of shoulder subluxation confirmed by radiography; submit disproportionate hemiparesis with brachial predominance.	Pacemaker; presence of orthopedic disease and / or prior rheumatic shoulder; clinical instability (hypertension and diabetes mellitus uncontrolled); more than one episode of stroke; use of analgesic medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-87rdwv	Association between facial types, orofacial pain and mastication	Recruiting	Observational	2014-09-01	<NULL>	<NULL>	331	Association between craniofacial morphology, temporomandibular disorders, bite force, masticatory performance and chewing ability	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-87rdwv	<NULL>	Experimental group: volunteers with TMD, established through the application of the RDC / TMD; both genders; aged between 18 and 45 years; complete permanent dentition (optional presence of third molars) and no more than a missing premolar in the quadrant. For the control group the inclusion criteria are the same, except the presence of TMD.	Subjects presenting history of oral and maxillofacial surgery, facial trauma to the jaw, orthodontic treatment in less than two years, bone disease or neuromuscular facial malformations, severe malocclusion (anterior open bite, unilateral or bilateral posterior crossbite), parafunction habits, facial deformities, or pregnant patients were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-79s56s	Evaluation of three Treatments of vivax Malaria	Recruiting	Intervention	2014-09-10	<NULL>	<NULL>	332	Safety and Efficacy Evaluation of Artemisinin-based Combination Therapy for the Treatment of Uncomplicated Plasmodium vivax Malaria	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2012-08-09	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-79s56s	<NULL>	Age between 18 and 70, or weight between 50 kg and 80 kg; Mono-infection by P. Vivax confirmed by microscopy; Asexual parasite count &gt; 250/µl; Axillary temperature &gt; 37,5 °C or history of fever during the 48h prior to recruitment; Ability to swallow the medicaments under study; Availability and desire to observe the schedule of evaluations of the study; Agreement with and signing of the Term of Free and Informed Consent.	Presence of clinical conditions related to malaria vivax that require hospitalization (coma, respiratory dysfunction or severe anemia); Presence of febrile conditions  due to another disease besides malaria (for example, measles, acute infection of the respiratory tract, diarrhea with dehydration) or other chronic or severe comorbidities (for example, kidney, cardiac or chronic liver disease, and HIV/AIDS); Use of medicaments that can interfere in the pharmacokinetics of the antimalarial medicaments under study; Hypersensibility to the medicaments under study; History of the presence of deficiency of glucose-6-phosphate dehydrogenase; Any significant disease or clinical findings during the medical evaluation or physical examination that the investigator considers might interfere in the study; Pregnancy (confirmed by ? HCG) or breastfeeding; Use of antimalarial treatment less than 63 days prior to the symptoms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-88b5jr	Diagnostic study of Dengue in Emergency Care	Recruiting	Intervention	2014-09-11	<NULL>	<NULL>	333	Pragmatic Diagnostic Trial  of Cinical-Laboratory Algorithm for Dengue in Emergency Care Units in Rio de Janeiro	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-05	Conselho Nacional de Desenvolvimento Científico e Tecnológico (	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-88b5jr	<NULL>	Patients of both genders over 18 years assisted in Emergency Care Units in Rio de Janeiro, with fever for up to 3 days without other infectious etiology.	pediatric patients and those with other infectious etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-459y54	Use of TENS for reducing pain after cesarean	Not yet recruiting	Intervention	2014-09-15	<NULL>	<NULL>	334	Effect of TENS in pain after cesarean	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-459y54	<NULL>	Women undergoing cesarean delivery with incisional pain intensity greater than three on a numeric scale with 15 years or more. Mothers who are in the period between eight and 12 hours postpartum. Physical status I or II, according to the American Society Anesthesiology. Absence of hearing impairment or visual communication, or even have no cognitive disorder / psychiatric impairment. These women should be admitted to the maternity João Firpo Hospital Santa Isabel (Aracaju / Se).	Women with some post-cesarean complications. Mothers with their newborns in the intensive care unit neonatal. Women who had prior use of Transcutaneous Electrical Nerve Stimulation. Those with contraindications to the use of Transcutaneous Electrical Nerve Stimulation. Mothers with an inability to understand the instructions or consent for the study. Women with hepatic impairment, renal or cardiovascular. Neurological disorders or lung disease. Heart disease. Women taking antidepressants. Use of psychoactive drugs or glucocorticosteroids in the week prior to the study. Use of pacemakers. Postpartum women with morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-37jpt3	Comparison of the effect the lysine clonixinate (Dolamin ®) and ibuprofen (Advil ®) in reducing pain in patients with tendinopathy	Data analysis completed	Intervention	2014-09-16	<NULL>	<NULL>	335	A Randomized single-blinded, parallel group and unicentric Phase IV Clinical Study of non-inferiority, comparing the drug Lysine Clonixinate (Dolamin®) and Ibuprofen (Advil®) in reducing acute pain related to tendinopathy in patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-05-23	CREB-Centro de Reumatologia e Ortopedia Botafogo Sociedade Simples LTDA	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-37jpt3	<NULL>	"Volunteers be carrying from acute pain related to tendinopathy (tendinitis, tenosynovitis and bursitis of the shoulders, wrists / hands, knees and ankles / feet and require immobilization;
age between 18 and 65 (sixty five) years; Indicate, in max, grade 7 in the Visual Analogue Scale (VAS) of pain; Having signed and dated the &apos;Informed of Consent Form&apos; (ICF) specified for this study, prior to any participation in procedures related to it."	"None of the patients included in this study should be carrying from acute pain related to tendinopathy at the hip; having a history of asthma or bronchospasm, nasal polyps, allergic reactions and / or induced by acetylsalicylic acid (aspirin) or other anti-inflammatory drugs; history of gastrointestinal bleeding due to the use of NSAIDs; is receiving treatment with other anti-inflammatory drugs, corticosteroids or analgesics; Is receiving treatment with oral anticoagulants, ticlopidine, heparin and thrombolytics; be pregnant and / or lactating; be hypersensitive (allergic) to any of the components of the formula;
8. Be a regular user of alcohol and barbiturates; have hepatic or renal impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4wkr8y	Influence of the practice of Pilates in the strength of the pelvic floor muscles on the loss of urine and back pain in the last trimester of pregnancy	Not yet recruiting	Intervention	2014-09-18	<NULL>	<NULL>	336	Clinical trial: influence of the practice of Pilates on the incidence of urinary incontinence, perineal strength low back pain in the third trimester	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Mariana Mara Buen	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4wkr8y	<NULL>	First pregnancy. Greater than 18. There have reports of urinary incontinence pre pregnancy and low back pain. Gestational age of 20 to 25 weeks. Pregnancy single fetus.	Women with neurological antecedents that caused cognitive deficit or lower limb motor. Women with physical and / or mental limitations for running exercises. Restrictive lung diseases. Heart Disease. Having performed regular physical exercise or Pilates in the past six months. Pre pregnancy Body Mass Index (BMI) &gt; or equal to 30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8wx7qb	Evaluation of phone calls in promoting self-care in Diabetes	Data analysis completed	Intervention	2014-09-22	<NULL>	<NULL>	337	Evaluation of monitoring telephone in promoting self-care in Diabetes in primary health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-06	Universidade Federal de Minas Gerais	Heloisa de Carvalho Torres	https://ensaiosclinicos.gov.br/rg/RBR-8wx7qb	<NULL>	Members diagnosed with Type 2 Diabetes Mellitus; have between 30 and 80 years; own mobile phone or fixed line.	Members diagnosed with Type I Diabetes; not answer calls for more than five consecutive attempts made; users with psychiatric disorders or complications of the disease which adversely affects the ability to answer the questionnaire of self-care; users who have moved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-3gm6w5	Glucose 25% and sucking gloved finger for pain relief of premature newborns during capillary glucose by heel prick	Recruiting	Intervention	2014-10-02	<NULL>	<NULL>	338	Glucose 25% and nonnutritive sucking for pain relief in premature undergoing heel lance: a clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-30	Escola de Enfermagem Anna Nery da Universidade Federal do Rio de Janeiro	Maternidade Escola da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3gm6w5	<NULL>	Prematures with gestational age at birth between 29 and 36 weeks complete; age after birth more than 06 hours; apgar score at five minutes of 7 or more; clinical stability with physiologic parameters at heart rate between 120 to 160 and oxygen saturation more than 89%; antecipated clinical need for at least 3 routine heel stick to control blood glucose after six hours post birth	"Ventilatory assistance; intraventricular hemorrhage(grades III
and IV)or leukomalacia; cromossomal disorders or malformations affecting central nervous system; disorders affecting cardiovascular system, presence of necrotizing intestinal colitis or hyperglycemia; use of opioids, corticosteroids, or other drugs that interfere with the responses to pain, children of mothers who use illegal drugs, trauma from childbirth as skin lesions, fractures, intracranial hemorrhage, visceral ruptures"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2h5b53	Carbohydrate supplementation in athletes	Data analysis completed	Intervention	2014-10-02	<NULL>	<NULL>	339	Effects of carbohydrate supplementation on physical performance, and hormonal,  immunological and psychological responses during and after an intensive training program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-08	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2h5b53	<NULL>	Male athletes, aged between 20 and 40 years old, running above 50 km / week, and minimum of 4 years of intense physical training.	Presence of orthopedic, or cardiovascular or hormonal / metabolic diseases, or anemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-79nxr8	Effect of supplementation of chromium in glucose of diabetic patients	Recruitment completed	Intervention	2014-10-08	<NULL>	<NULL>	340	Effect of Supplementation of Chromium Picolinate on blood glucose with Type 2 Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-11	Universidade Feral do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-79nxr8	<NULL>	Volunteers diagnosed with type two diabetes mellitus according to the criteria of the American Diabetes Association two thousand and eleven; both genders; presenting glycated hemoglobin greater than or equal to seven percent; not in use of insulin; age between thirty and seventy years; not have taked mineral vitamin supplement in the last three months	Volunteers taking insulin and / or corticosteroids; showing endocrinopathy (cushin syndrome; acromegaly; hyper or uncontrolled hypothyroidism); kidney disease; cancer; infection and anemia; pregnant women; lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-4rprbd	Impact assessment of molecular tests for drug resistant tuberculosis diagnosis in Brazil	Recruiting	Intervention	2014-04-02	<NULL>	<NULL>	341	Policy Relevant Outcomes from Validating Evidence on Impact of Line Probe Assay and MTB/RIF on Presumptive Diagnosis of DR-TB in Brazil	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2011-10-14	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Centro de Referência Professor Hélio Fraga	https://ensaiosclinicos.gov.br/rg/RBR-4rprbd	<NULL>	Age over 18 years; individuals or their legal representatives who sign the Consent Free and Clear; TB resistant suspected cases defined by the presence of history of previous treatment for TB; patients hospitalized in referral centers for TB at least once in the past 2 years; staying in nursing homes / hostels; homeless population; drug / alcohol abusers; HIV seropositive individuals and contacts of tuberculosis resistant patients positive smear	Pregnant; refusal to participate in any phase of the study; patients with resistant tuberculosis confirmed by culture and with appropriate treatment in progress; patients with tuberculosis results from another laboratory that will used by the physician to initiate anti tuberculosis treatment; extra-pulmonary TB suspected patients  (without sputum sample) and permanent patients in police and prisons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-9829jk	The efficacy of speech therapy in post-intubated patients with swallowing disorder	Recruitment completed	Intervention	2014-10-15	<NULL>	<NULL>	342	The efficacy of speech therapy in post-intubated patients with oropharyngeal dysphagia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-15	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9829jk	<NULL>	Volunteers of both genders, aged between 18 and 100 years who received orotracheal intubation in more than 48 hours and extubation between two and seven days	Clinically very serious volunteers, who are making use of tracheostomy, which are not making use of a nasogastric tube; diagnosis of neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-25b7xh	Effect of the pH, consistency and quantity of fluoride of the toothpaste in the fluoride retention on enamel surface	Data analysis completed	Intervention	2014-10-21	<NULL>	<NULL>	343	Effect of the pH, consistency and fluoride concentration of liquid dentifrices in caries control of fluoridated and not fluoridated áreas: randomized clinical trials	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-08-02	Faculdade de Odontologia de Bauru	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-25b7xh	<NULL>	Healthy volunteers, aged between 20 and 35 years old, not using orthodontic appliances and that have not been involved in other studies 3 months before the present research.	Volunteers using orthodontic appliances; volunteers using other fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-6cgy23	Analysis of the factors that may be related to the emergence of postural deviations in school.	Recruitment completed	Observational	2014-10-24	<NULL>	<NULL>	344	Analysis of risk factors related to postural changes in children from the city of Santa Cruz / RN	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-03-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6cgy23	<NULL>	The study included children and adolescents aged between 07 and 17 years enrolled in primary or secondary schools, municipal or urban schools, in the morning or evening, in the city of Santa Cruz / RN, whose parents or guardians signed the informed consent (IC) approved by the Ethics in Research Involving Human UFRN.	Presence of physical and / or mental efficiency, orthopedic injury, trauma and / or rheumatologic that prevented the maintenance of orthostatic position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-42c6gz	Characterization of trigger points in the rectus abdominis muscle in women with chronic pelvic pain using electromyography.	Data analysis completed	Observational	2014-11-05	<NULL>	<NULL>	345	Characterization of local mechanisms (trigger points) of abdominal myofascial syndrome in women with chronic pelvic pain using surface and needle electromyography.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-09-19	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto	Departamento de Ginecologia e Obstetrícia - Comissão de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-42c6gz	<NULL>	Women with chronic pelvic pain; age over 18 years; presence of all clinical diagnostic criteria for abdominal myofascial pain syndrome.	Women with typical clinical symptoms of endometriosis or painful bladder syndrome or irritable bowel syndrome or other disease that justify or contribute to chronic pelvic pain; endometrioma or hernia evidenced by ultrasound of abdominal wall; obesity (BMI &gt; 30 kg/m²); use of anticoagulant; coagulation disturbance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5tzcnw	Influence of the depression treatment with escitalopram in mild to moderate arterial hypertension	Data analysis completed	Intervention	2014-11-05	<NULL>	<NULL>	346	Influence of the depression treatment with escitalopram in mild to moderate arterial hypertension	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-03-01	Marcello Finardi Peixoto	Marcello Finardi Peixoto	https://ensaiosclinicos.gov.br/rg/RBR-5tzcnw	<NULL>	18 to 65 years; arterial hypertension stage 1 or 2; major depressive disorder	Liver insuficiency; cardiac insuficiency, renal insuficiency; secundary arterial hypertension; use of psycotropics; psychotic disorder; alcohol or substances disorder; suicide risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-8k3cyk	Training Program for residents in breaking bad news in perinatology using standardized patients	Recruiting	Intervention	2014-11-05	<NULL>	<NULL>	347	Evaluation of a training program efficacy for residents in breaking bad news in perinatology using standardized patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-8k3cyk	<NULL>	First to fourth year residents in the gynecology and obstetrics program at FCM Unicamp; first and second year residents from pediatrics; third and fourth year residents from the Neonatal program.	Third and fourth year pediatric residents from areas other than Neonatology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-78m24n	Occupational exposure to waste anesthetic gases: evaluation of toxic effects in genetic material and antioxidant system in recently exposed professionals	Recruitment completed	Observational	2014-11-07	<NULL>	<NULL>	348	Determination of waste Anesthetic Gases and evaluation of genomic and oxidative stress in newly exposed professionals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-12	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-78m24n	<NULL>	Medical residents; young; 25 to 35 years of age; healthy; of both genders; with or without exposure to waste anesthetic gases.	Medical residents with neoclassic disease; inflammatory or infectious conditions; smokers; alcoholics; history of drug abuse; use of medication or antioxidant supplementation; recent exposure to radiation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5vsmm6	Evaluation of intestinal hormones in healthy patients and in obese patients with and without type 2 diabetes through isoglycemic clamp before and after stomach reduction surgery	Recruitment completed	Intervention	2014-11-11	<NULL>	<NULL>	349	Evaluation of the incretin effect in healthy patients and in obese patients with and without type 2 diabetes through Isoglycemic Clamp before and after surgery (Biliopancreatic Diversion) or drug (Inhibitor of Dipeptidyl Peptidase IV [DPP-IV])	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-25	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5vsmm6	<NULL>	Age between 30 and 60 years, type 2 diabetic patients without medication for diabetes or who are not making use for at least 3 months; weight variation of less than 5% in the last three months; ability to understand the study procedures and voluntarily agree to participate in the study and signed an informed consent form.	Age under 30 and over 60, patients with type 2 diabetes using insulin, type 2 diabetics with poorly controlled diabetes (glycated hemoglobin A1c greater than 8.5%), BMI less than 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; changing functions renal function (creatinine greater than 1.4 mg / dl in women and greater than 1.5 mg / dl in men) and hepatic ALT and / or AST 3 times above normal; recent history of malignancy (less than 5 years), use of injectable or oral steroids for more than 14 consecutive days in the past 3 months, or with some drug side effects on glucose metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-3h3x44	Treatment with Oral Breathing Exercises	Recruitment completed	Intervention	2014-11-17	<NULL>	<NULL>	350	Interdisciplinary approach of mouth breathers: use of Isostreching in treating respiratory and postural Techniques and Orofacials	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-05-07	Universidade Federal de Alfenas- UNIFAL-MG	Secretaria de Saúde da prefeitura Municipal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3h3x44	<NULL>	Young people with clinical diagnosis of dental and oral breathing; both genders; aged 6 to 20 years; with consent of parents or guardians for participation in this study	Young people with neurological problems; with heart problems, with agenesis of lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-45yn9v	Evaluation of mandibular movements and chewing in women with face pain	Recruiting	Intervention	2014-11-18	<NULL>	<NULL>	351	Influence of education and self-care modalities on pain and function related to Chronic Temporomandibular Disorder: clinical trial, randomized, double-blinded, controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-20	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-45yn9v	<NULL>	Females, aged between 18 and 70 years, presenting chronic pain related to chronic temporomandibular disorder; not being in treatment for this painful condition; not be starting any treatment for any other painful condition such as fibromyalgia; back pain; neck pain or rheumatic changes; natural teeth or fixed prosthesis with posterior contention; be capable to reading and writing	Using removable partial denture; using complete denture or implantssuported fixed; debilitating systemic diseases as Parkinson or Alzheimer; use of a cardiac pacemaker; absence of severe malocclusions as crossbite; anterior open bite; midline deviation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-86dcdx	Comparison of Bronchoalveolar Lavage and Tracheal Aspirate in the diagnosis and therapy of ICU patients with Ventilator-Associated Pneumonia	Recruitment completed	Intervention	2014-11-25	<NULL>	<NULL>	352	Comparative study of Bronchoalveolar Lavage and Tracheal Aspirate in the diagnosis and treatment of Ventilator-Associated Pneumonia	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-08-12	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-86dcdx	<NULL>	"The patients under mechanical ventilation for at least 48 h who presented with new or progressive pulmonary infiltrates on X-rays plus at least two criteria among fever &gt; 38°C, purulent tracheal secretions, and leukocytos greater than 10,000 cells/mm3 or leukopenia of 4,000 cells/mm3, were screened for enrollment.These patients were randomized to undergo BAL (BAL group - 1) or EA (EA group - 2).
Both BAL fluid (BALF) and EA samples were quantitaively cultured. The patients whose cultures were positive with more than 10.000 CFU/mL in BALF cultures and with more than 100.000 CFU/mL in quantitatively endotracheal aspirate cultures (QEACs)— were included in the
study."	"The exclusion criteria were a diagnosis of AIDS and inappropriate
respiratory samples (&gt; 10 squamous cells in the lower field magnification in EA
smears or &gt; 1% bronchial cells in BALF smears). cases with BAL fluid with more than 1% of bronchial cells."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-8333q9	Early skin to skin contact: effect on maternal stress and mother-child interaction	Recruitment completed	Intervention	2014-11-25	<NULL>	<NULL>	353	Early skin to skin contact: effect on maternal stress and mother-child interaction at 2 and 4 months corrected gestational age	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Pós-graduação em Ciências da Saúde - Saúde da Criança e do Adolescente / Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8333q9	<NULL>	Preterm newborns with birth weights between one thousand and eighteen hundred grams; preterm newborns stable in terms of respiratory and hemodynamic submitted or not in ventilatory support, between twenty four and seventy two hours of postnatal life; preterm newborns classified as appropriate for gestational age; mothers who did not show signs of psychological change	Preterm newborns with Apgar score less than seven at five minutes of life; newborns with congenital malformations; preterm newborns who had intraventricular hemorrhage and or hydrocephalus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5wkdk7	Effects of the pressure of the hands on the chest to remove secretions from the lung in patients on life support	Recruiting	Intervention	2014-11-26	<NULL>	<NULL>	354	Effects of chest compression in patients on mechanical ventilation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5wkdk7	<NULL>	Patients of both genres; aged between 18 and 80 years; in use of an endotracheal tube or tracheostomy; receiving ventilatory support; sedated; hemodynamically stable; no active participation in the fan; having diagnosed the presence of lung infection	History of pulmonary disease; hemodynamic instability; abnormalities of the chest or abdominal wall; obesity; severe scoliosis; pregnancy; cardiac pacemaker; pneumothorax; flail ches;, presence of vascular fragility; acute respiratory distress syndrome; thrombocytopenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-4m5yhw	The effect of video games and conventional physiotherapy in the physical fitness of elderly	Data analysis completed	Intervention	2014-12-02	<NULL>	<NULL>	355	Analysis of the intervention on physical fitness of elderly San Pedro neighborhood , Teresina, Piaui : a comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Faculdade Santo Agostinho	Faculdade Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-4m5yhw	<NULL>	Of age or over 60 years , a medical certificate with authorization for physical activity , participating constantly in the center of coexistence and accept volunteer study .	Motor or cognitive disabilities that prevented the activity .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-8v5s6s	"Study of the use of LASER and Led light and exercises in Herniated Lumbar Disc


Study of the Efficacy of Laser, Led and Exercises Herniated Lumbar Disc"	Recruiting	Intervention	2014-12-02	<NULL>	<NULL>	356	Effects of low power LASER and LED associated with exercises and positioning in Lumbar Disc Herniation: a randomized clinical  trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-16	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8v5s6s	<NULL>	Patients with HDL of L4,L5 and L5,S1 spaces with radiculopathy; patients referred by a neurosurgeon, neurologist, orthopedist and rheumatologist; compatibility between the MRI image and clinical symptoms.	Presence of low back pain without radicular manifestation; patients undergoing any surgery in the lumbar spine; pregnancy; fracture or tumor in the lumbar spine; history of collagen disorder; history of neoplasic disease;  patients with disc herniation in the spaces L2,L3 and L3,L4; individuals with pacemaker or with skin diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-9q7dy5	Oral treprostinil open label study  in subjects with pulmonary arterial hypertension	Recruiting	Intervention	2014-12-03	<NULL>	<NULL>	357	"An open-label extension study of UT-15C in subjects with pulmonary arterial hypertension - a long-term follow-up to
protocol TDE-PH-310"	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-09-01	Irmandade da Santa Casa de Misericórdia de Porto Alegre - ISCMPA	Pharmaceutical Research Associates Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9q7dy5	<NULL>	Patients who participated in the study TDE-PH-310 and met the definition of clinical worsening (as specified in the protocol TDE-PH-310), continued treatment with study drug, was compliant with assessments and study procedures during TDE-PH-310 or were enrolled in that study when it was discontinued by the sponsor. Women of childbearing potential must be on real abstinent or use two highly effective contraceptive methods throughout the study and for at least 30 days after discontinuation of study medication. Men participating in the study should use condoms throughout the study and for at least 48 hours after the last dose of study medication.	Pregnant or breastfeeding female patient. Patient receiving therapy with prostacyclin by infusion or inhalation. Patient who was early withdrawn from the study TDE-PH-310 due to reasons other than the event of clinical worsening. Patient developed a concomitant disease or condition during participation in the original study TDE-PH-310, which in the opinion of the study physician, would represent a risk to the general health if the patient were enrolled in this extension study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-7jwsf6	Methods of feeding the premature newborn	Recruitment completed	Intervention	2014-12-04	<NULL>	<NULL>	358	Methods transition of offer of diet to premature newborn	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-10	Faculdade São Lucas	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7jwsf6	<NULL>	"Will be included in newborns and preterm infants of both genders, with a gestational age of at least 32 weeks in the sample and 
maximum of 36 weeks, appropriate for gestational age, who have not received oral diet weight. The mothers of these infants 
will necessarily express the desire to breastfeed your child breastfed."	"Infants with gestational age less than 32 weeks or greater than 37 weeks, small or large for gestational age are excluded, 
who have received oral diet, as well as infants who show any neurological abnormalities (including bleeding 
peri-grades III and IV intraventricular and periventricular leukomalacia), chronic pulmonary distress, congenital heart defects, craniofacial malformation and 
positive serum with human immunodeficiency virus. The mothers who did not express an interest in breastfeeding will also be considered to 
child or are not watching their children due to hospitalization, death, come from another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-386svr	Assessment of breathing and exercise capacity of patients with kidney disease that perform breathing exercises	Recruitment completed	Intervention	2014-12-09	<NULL>	<NULL>	359	Functional, physiological assessment and nutritional status of individuals in hemodialysis undergoing respiratory kinesiotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-10	Universidade Federal de Goiás	Viviane Soares	https://ensaiosclinicos.gov.br/rg/RBR-386svr	<NULL>	Patients with renal failure performing hemodialysis for over 3 months; aged between 18 and 70 years; males; with medical clearance to be submitted to inspiratory muscle training; Following the training protocol three times per week	Patients with neurological deficit; chronic lung disease; severe heart disease (unstable angina, previous myocardial infarction, cardiac surgery); infectious disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5xnyjs	Exercise in the Prevention of Falls in Elderly Residents in Institutions for the Aged	Recruitment completed	Intervention	2014-12-09	<NULL>	<NULL>	360	Exercise in the Prevention of Falls in Elderly Institutionalized	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-31	Fundação Universidade de Passo Fundo	Camila Tomicki	https://ensaiosclinicos.gov.br/rg/RBR-5xnyjs	<NULL>	People aged 60 and over; both sexes; seniors who possessed a position to understand simple verbal order; elderly and / or guardians who agreed to participate	Seniors unable to take exercise; elderly without cognitive ability, that prevented the understanding and implementation of the proposed exercises; elderly victims of hospitalization during the period designated for intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-3d29s2	Benefits of aerobic exercise on the cardiovascular system in patients with coronary artery disease.	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	361	Influence of interval aerobic exercise training on cardiorespiratory and metabolic variables and inflammatory markers in patients with different level of coronary artery lesions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-14	Departamento de Fisioterapia da Universidade Federal de São Carlos	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3d29s2	<NULL>	Volunteers men, aged 35 and 65 years with coronary artery disease udergoing percutaneous coronary intervention (&gt; 3 months), and/or cardiovascular risk factor (obesity, smoking, drinking, sedentary lifestyle, hypertension, non-insulin-dependent diabetes and dyslipidemia).	Patients with frequent extrasystoles, chronic obstructive pulmonary disease, unstable angina, osteomuscular disorders, diabetes mellitus – users of insulin, renal failure, and sequelae of stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-674y4g	Health care college student: evaluation of Anxiety and orofacial pain	Recruitment completed	Intervention	2014-12-09	<NULL>	<NULL>	362	"Health care college student: assessment and treatment of Anxiety and and the presence of
TMD"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal de Alfenas- UNIFAL-MG	Universidade Federal de Alfenas- UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-674y4g	<NULL>	Students of the courses  pharmacy, physiotherapy and dentistry; Federal University of Alfenas of nursing, students identified with high levels of anxiety through Questionnaire STAI State and Trait; older than 18 years; of both genders	Students in other types of treatment for anxiety and temporomandibular dysfunction; pregnant; students who do not agree to participate; those who do not attend at least 10 sessions of auriculotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-9c8wng	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	363	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9c8wng	<NULL>	Aged 45 to 85 years; both genders; be on stage II of Peropheral Artery Disease in one or both limbs, according with Fontaine criteria; be able to walk on a treadmill at least two minutes at a speed of 3.2 km/h; and, be with systolic and diastolic blood pressure levels less than 160 and 105 mmHg, respectively	Individuals who are in use of beta-blockers, calcium channel blockers or vasodilators non-dihidropiridinico; presenting complex arrhythmias or ischemia that contraindicate physical activity; having diabetes with complications or autonomic dysfunction, who are obese and they have amputated limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-6qkjzv	Evaluation of chewing elderly patients with Rheumatoid Arthritis	Recruiting	Observational	2014-12-15	<NULL>	<NULL>	364	Evaluation of masticatory capacity, pattern of mandibular movement, maximum bite force and quality of life in elderly patients with Rheumatoid Arthritis.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-06-10	Faculdade de Odontologia de Piracicaba - UNICAMP	Fundação de amparo à pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-6qkjzv	<NULL>	Volunteer possessing equal to or above 60 years of age; both genders; partially or total edentulous	Individuals who present severe malocclusions; submit systemic disease that could also  affect the muscle activity;dementia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-3p7zcf	Effectiveness comparison of physiotherapy with balance and gait exercises and physical therapy with strengthening exercises in patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2014-12-17	<NULL>	<NULL>	365	Effectiveness comparison of the Bobath concept versus muscle strength training to improve motor and non-motor symptoms in patients with Parkinson&apos;s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3p7zcf	<NULL>	"Medical diagnosis of Parkinson&apos;s disease, according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria): First step: Bradykinesia associated with at least one of the following symptoms: resting tremor, muscle stiffness or alteration of postular reflexes; Second stage: diagnostic exclusion criteria; Lack of clinical signs of secondary forms of parkinsonism or parkinsonism; No change in eye movements, dementia in the first year of symptoms,  cerebellar ataxia, severe dysautonomia, falls and serious imbalance in the first year of symptoms, etc. Third stage: Criteria for diagnoses support; Home unilateral and asymmetrical course;
The first side is affected the most committed throughout evolution; Presence of resting tremor; Progression of symptoms;
Excellent response to levodopa; Response to levodopa lasting five or more years; Levodopa-induced dyskinesia; Clinical course of ten years or more. Individuals over 50 years. Do not  institutionalized. Mini Mental score at least that does not characterize cognitive impairment. Hohen Yahr 1.5 to 3.0. What part of the project accept and sign the consent according term to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (CNS)."	Individuals who perform other therapeutic treatment beyond drug that has change in medication during the study or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive deficits or understanding. Change in the stabilization of the antiparkinsonian doses throughout the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-6n87rs	Study of alterations in the CYP2C19 gene and platelet activity in patients submitted to coronary angioplasty	Recruitment completed	Observational	2015-01-05	<NULL>	<NULL>	366	Study of CYP2C19, ABCB1 and PON1 polymorphism in patients submitted to percutaneous coronary intervention and correlation to platelet aggregation in a brazilian population receiving simple and double anti-platelet therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6n87rs	<NULL>	"Consecutive patients submitted to percutaneous coronary intervention at the interventional cardiology unit at FMRP-USP.
Agreement with the consent form."	Patients submitted only to balloon angioplasty or with contraindication to clopidogrel use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-9hb8v8	Study of balance over 1 year in patients with acquired deafness after  cochlear implantation (CI)	Recruitment completed	Intervention	2015-01-08	<NULL>	<NULL>	367	Sequential study of vestibular function  post cochlear implantation (CI) in postlingually patients	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9hb8v8	<NULL>	Patients with post lingual deafness; bilateral sensorineural hearing loss severe to profound; no benefit with the use of hearing aids or those with indices below 50% in sentence recognition using the best possible bilateral fitting tests.	patients with obliteration of the tympanic cavity; patients with indication for middle fossa surgical approach; orthopedic, neurological or visual disorders that could interfere with the results of the computerized dynamic posturography	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-2sgtn2	Effectiveness of Pilates and ingestion of Green Tea in elderly patients who have Metabolic Syndrome	Not yet recruiting	Intervention	2015-01-12	<NULL>	<NULL>	368	Effectiveness of the Pilates method and the supplementation with Green Tea (Camelia Sinensis) in the biochemical, oxidative markers, antioxidant status levels and in gene expression in elderly patients with Metabolic Syndrome - clinical trial randomized double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-07	Pontifícia Universidade Católica do Rio Grande do Sul	Programa de Pós-Graduação em Gerontologia Biomédica do Instituto de Geriatria e Gerontologia da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-2sgtn2	<NULL>	Aged over 60 years; female; have metabolic syndrome.	Have cardiovascular disease; have liver disease; gastric disease; thyroid problems; memory problems; anxiety and sleep disorders;have physical problems that preclude training with pilates;have done in the past or is doing pilates or other form of physical exercise on a regular way; intake green tea by regular or habitual way.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-4dxw4p	Vestibular rehabilitation and antivertigo drugs use	Recruitment completed	Intervention	2015-01-12	<NULL>	<NULL>	369	Vestibular rehabilitation and pharmacoterapy	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-08	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-4dxw4p	<NULL>	Individuals of both genders over 18 years of age, with central or peripheral vestibular disorders, diagnosed clinically by a physician specialist in the area, with vestibular symptoms.	Individuals with visual impairment and / or severe hearing, orthopedic dysfunctions that limit the performance of the proposed activities, cognitive impairment that impedes the collection of study data, nervous system injuries that cause motor impairments and / or sensory additional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-37f338	Comparative trial to evaluate the efficacy and safety of antibody treatment in patients with early breast cancer	Recruiting	Intervention	2015-01-12	<NULL>	<NULL>	370	A randomized, double-blind, phase 3 study evaluating the efficacy and safety of ABP 980 compared with trastuzumab in subjects with HER2 positive early breast cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-05-01	Associação Hospital de Caridade Ijuí	Amgen Inc.	https://ensaiosclinicos.gov.br/rg/RBR-37f338	<NULL>	"Females equal or older than 18 years of age. Histologically confirmed invasive breast cancer. Planning for surgical resection of breast tumor and sentinel node (SN) or axillary lymph node resection. Planning neoadjuvant chemotherapy. HER2 positive disease defined as: 3+ overexpression by immunohistochemistry (IHC) or HER2 amplification by fluorescence in situ hybridization (FISH). 
Measurable disease (assessment method used in order of priority: ultrasound, mammography, MRI, or physical examination) in the breast after diagnostic biopsy, defined as longest diameter equal to or longer than 2.0 cm. Known ER and PR hormone receptor status at study entry. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Left ventricular ejection fraction (LVEF) of equal to or more than 55% by 2D echocardiogram. Normal bone marrow function as defined by: absolute neutrophil count (ANC) higher than 1.5 x 10^9 g/dL (1,500/microL); platelets higher than 100 x 10^9 g/dL (100,000/microL); hemoglobin higher than 10.0 g/dL. Normal hepatic function as defined by: total bilirubin within normal institutional limits; aspartate aminotransferase (AST) and alanine aminotransferase (ALT); lower than 2.5 × the upper limit of normal (ULN); subjects with an elevated unconjugated bilirubin (Gilbert&apos;s syndrome) will be eligible if hepatic enzymes and function are otherwise within normal limits (ie, AST, ALT, and Alkaline Phosphatase are within normal limits), and there is no evidence of hemolysis. Normal renal function as defined by creatinine lower than 1.5 × ULN or estimated creatinine clearance (CrCl) equal to or higher than 50 mL/min calculated by the Cockcroft- Gault method. 
Subjects must sign an IRB/EC-approved informed consent form before any study specific procedures."	Bilateral breast cancer. Presence of known metastases. Received prior treatment, including chemotherapy, biologic therapy, radiation or surgery with the exception of diagnostic biopsy for primary breast cancer. Other concomitant active malignancy or history of malignancy in the past 5 years except treated basal cell carcinoma of the skin or carcinoma in situ of the cervix. Pre-existing clinically significant (equal to or higher than grade 2) peripheral neuropathy. Any history of documented or current congestive heart failure, current high-risk uncontrolled arrhythmias, current angina pectoris requiring a medicinal product, current clinically significant valvular disease, current evidence of transmural infarction on electrocardiogram (ECG), or current poorly controlled hypertension. Severe dyspnea at rest requiring supplementary oxygen therapy. History of positivity for hepatitis B surface antigen, hepatitis C virus, or HIV. Recent infection requiring a course of systemic anti-infectives that were completed equal to or less than 14 days before enrollment (with the exception of uncomplicated urinary tract infection). Woman of childbearing potential who is pregnant or is breast feeding. Woman of childbearing potential who is not consenting to use highly effective methods of birth control (eg, abstinence, sterilization, birth control pills, Depo-Provera injections, or contraceptive implants) during treatment and for an additional 4 months after the last administration of the protocol specified treatment. Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study. Other investigational procedures while participating in this study are excluded. Subject has known sensitivity to any of the products to be administered during the study, including mammalian cell derived drug products, trastuzumab, murine proteins, or to any of the excipients. Subject previously has enrolled and/or has been randomized in this study. Subject likely to not be available to complete all protocol required study visits or procedures. History or evidence of any other clinically significant disorder, condition or disease (with the exception of those outlined above) that, in the opinion of the Investigator or Amgen physician, if consulted, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-746nfd	Ventilation by nasal apparatus in preterm infants	Data analysis completed	Intervention	2015-01-15	<NULL>	<NULL>	371	Application of noninvasive positive pressure ventilation after extubation in neonates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-12	Universidade Federal de Minas Gerais	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-746nfd	<NULL>	Preterm newborns admitted to the Neonatal Intensive Care Unit of the Hospital Sofia Feldman, diagnosed with Respiratory Distress Syndrome of the Newborn (characterized by progressive respiratory failure after birth), gestational age less than or equal to 34 weeks and weights of the 500 grams less than or equal to 1500 grams classified as appropriate for gestational age, requiring ventilatory support after extubation	Newborns with congenital anomalies that compromise the cardiorespiratory system, genetic disorders, neuromuscular disease, malformations of the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-4pmzpq	The use of isostreching and exercises with video games in the treatment of Fibromyalgia	Recruitment completed	Intervention	2015-01-15	<NULL>	<NULL>	372	The use of isostreching and aerobic exercises with virtual rehabilitation in the treatment of Fibromyalgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-03	Universidade Federal de Alfenas (UNIFAL)	Universidade Federal de Alfenas (UNIFAL)	https://ensaiosclinicos.gov.br/rg/RBR-4pmzpq	<NULL>	Females; aged 18 years; Fibromyalgia diagnosis according to the American College of Rheumatology (ACR); history of widespread pain persisting for more than three months, affecting both sides of the body; presence of at least 11 of 18 tender points.	Pregnancy; presence of cardiovascular, orthopedic, systemic dermatological and neurological disorders; cognitive level inadequate to meet the guidelines offered	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-7w7ddy	Impact of psychotherapy in choosing sexual partners of patients with sexual deviance receiving drug treatment	Data analysis completed	Intervention	2015-01-21	<NULL>	<NULL>	373	Impact of psychotherapy in choosing sexual partners of patients with paraphilias receiving drug treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-18	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Carmita Helena Najjar Abdo	https://ensaiosclinicos.gov.br/rg/RBR-7w7ddy	<NULL>	Male, any ethnicity, age 18 years or more, literate; pedophiles who have sexual fantasies involving minors (no sexual activity or use of child pornography current or previous); sign the document authorizing the participation	Suicide risk, psychosis not stabilized; use of physical violence; previous or current history of children sexual abuse, possession, production, custody, disclosure or access to pornographic material involving childrens; patients planning child sexual abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5ky3ks	Comparison of the effectiveness of therapy  bromopride,metoclopramide,e ondasetron  Intramuscular for treatment of vomiting	Recruitment completed	Intervention	2015-01-21	<NULL>	<NULL>	374	Randomized  clinical trial, comparing the effectiveness of therapy bromopride, metoclopramide and ondansetron intramuscular for treatment of vomiting	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2013-08-01	União Brasileira de Educação e Assistência	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5ky3ks	<NULL>	children who have experienced two or more episodes of vomiting in the last 24 hours, aged 1 year to 12 years, both genders; medical indication for receiving intramuscular antiemetic; when the country or guardians agree with the inclusion of a dependent in the study	bromopride known allergy to metoclopramide and ondansetron; vomiting due to sedation, anesthesia or chemotherapy; teenagers pregnant and / or breastfeeding; heart disease, advanced renal disease, urinary tract infection, epilepsy, intestinal obstruction, appendicitis, meningitis and diabetes mellitus, malnutrition, pneumonia, brain tumor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-2bz8rj	Effects of cold water immersion after exercise	Recruitment completed	Intervention	2015-01-23	<NULL>	<NULL>	375	Immediate and delayed effects of cold water immersion after eccentric exercise protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-20	Universidade Estadual Julio de Mesquita Filho	Universidade Estadual Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-2bz8rj	<NULL>	Male; apparently healthy; physically active	Be alcoholics; drug use; smoking or anti-inflammatory medications chronically; present anemia; inflammation; diabetes; cardiovascular disease; liver problems; injury episode musculotendinous osteoarticular or lower limbs and / or spine in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5dbpbv	Influence of deep foot manipulation in balance	Recruiting	Intervention	2015-01-26	<NULL>	<NULL>	376	Influence of support area plantar in balance and electromyographic activity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Estadual Paulista &quot;Júlio Mesquita Filho&quot; Campus Marília. Faculdade de Filosofia e Ciências	Centro de Estudos da Educação da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-5dbpbv	<NULL>	"Gender: females 
Healthy older; between 65 and 75 years; living in the community.
Healthy Young; between 18 and 28 years; living in the community."	The voluntary doesn&apos;t manages to remain in the postures of the test; that has orthopedic injury over the last 6 months or neurological damage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-53c3b8	Effects of preventive and therapeutic interventions on the posture of students in the city of Santa Cruz / RN	Recruitment completed	Intervention	2015-01-27	<NULL>	<NULL>	377	Effects of a therapeutic exercise program and education about posture scoliosis posture of schoolchildren in the city of Santa Cruz, RN from the review by photogrammetry and visual assessment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-53c3b8	<NULL>	Children and adolescents aged 7:17 years; both genders; enrolled in elementary or middle school of municipal, state or private schools, urban or rural area, the municipality of Santa Cruz / RN; presenting scoliosis posture after physical therapy evaluation.	Children and adolescents with physical disabilities and / or mental injury and orthopedic, trauma and / or rheumatic preventing the maintenance of orthostatic position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-3gbyhk	Treating asthmatic children to prevent asthma exacerbations	Recruitment completed	Intervention	2015-01-27	<NULL>	<NULL>	378	Treating asthmatic children to prevent asthma exacerbations (TREXA-Minas Gerais Research Protocol)	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2010-12-06	Secretaria Municipal de Saúde de Belo Horizonte	Universidade Federal de Minas Gerais/Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-3gbyhk	<NULL>	Patients of both sexes aged six to eighteen years old, able to perform spirometry, suffering from mild persistent asthma in the past two years according to the criteria of the GINA (Global Strategy for Asthma) and fall into at least one of the following criteria: never used inhaled corticosteroids , anti - leukotrienes , beta- agonists, long-acting and report occurrence of exacerbations in the last two years, but none in the last three months; be in use of inhaled corticosteroids in the past eight weeks, at a daily dose equal to or greater than 250 mcg / day of beclomethasone; be well controlled in the last eight weeks with the use of 250 mcg of beclomethasone and no smoking during the last year.	"Treatment with other formulations of corticosteroids for any condition within the range defined prior to recruitment, e.g., oral route two weeks prior to the period of run in or parenteral route within   two weeks of screening visits; previous or current use of medication known to interact with the bioavailability of beclomethasone within a period of two weeks from the first follow up visit , namely , carbamazepine , erythromycin or other macrolide , phenobarbital , phenytoin , rifampin and ketoconazole; Spirometry showing pre bronchodilator FEV1 (forced expiratory volume in one second) less than 60 % of predicted value at first follow visit; hospitalization for asthma in the last year ; presence of other chronic or active disease other than asthma , namely , thyroid disease , diabetes mellitus , Cushing&apos;s disease , Addison&apos;s disease , liver disease or current medical conditions requiring oral corticosteroid therapy , history of cataract, glaucoma or any other condition medical associated with possible adverse effect of systemic corticosteroids ; asthma exacerbation in the last three months or more than two in the last year ; history of an exacerbation that required intubation , mechanical ventilation or seizure resulting in hypoxia ; previous history of adverse reactions to inhaled corticosteroids ; use of oral or injectable vaccines for for three months or more ; inability to perform spirometry and exhaled nitric oxide ; subjective impression of the researchers that the family or  patient will not adhere to treatment or may be transferred from the influence area of a Secondary Reference Units, namely, Campos Sales , Saudade , and Padre Eustáquio outpatient clinic.
Individuals who do not qualify to enter the run in period for reasons that can be overcome with time and training may be admitted to study at a later time."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-4t57rs	Effects of elastic tape on fuctional activities on healthy young subjects	Recruiting	Intervention	2015-01-30	<NULL>	<NULL>	379	Effects of Kinesiotaping on functional performance on healthy young subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4t57rs	<NULL>	Healthy male subjects; aged 18 to 30 years; Physically active; Height between 1.65 m to 1.85 m; absence of pain and symptoms musculoskeletal	Presence of open wounds or scars in the region of application of KT; hypersensitivity and erythema; lower limb injury in the last 6 months prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-6jd8nq	Effect of the Pilates in elderly	Data analysis completed	Intervention	2015-02-03	<NULL>	<NULL>	380	Effect of the method Pilates in relation:  thoracic hyperkyphosis and balance postural in elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências (FFC)- Universidade Estadual Paulista &apos;Júlio de Mesquita Filho&apos; (UNESP)	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-6jd8nq	<NULL>	Volunteers of the feminine gender,  aged between 60 and 75 years, angle larger than 40º in the curvature of the thoracic spine in the sagittal plane.	They don&apos;t present neurological sequelae, motor and comprehension deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5d98rs	Use of the device Magic Touch for the Treatment of Coronary Lesions	Not yet recruiting	Intervention	2015-02-03	<NULL>	<NULL>	381	Magic Touch	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto Dante Pazzanese de Cardiologia	Hospital Bandeirantes	https://ensaiosclinicos.gov.br/rg/RBR-5d98rs	<NULL>	The patient must be more or equal 18 or less or equal 80 years of age; Symptomatic ischemic heart disease; Acceptable candidate for coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty ; The Patient is willing to comply with specified follow-up evaluations;  The Patient or legally authorized epresentative has been informed of the nature of the study, agrees to its provisions and has been provided written informed consent, approved by the appropriate Medical Ethics Committee (MEC), Institutional Review Board (IRB), or Human Research Ethics Committee (HREC);Patients with restenosis of native coronary artery previously stenting (BMS) (Cohort A) and patients with single de novo lesion not treated with stent in the target vessel (Cohort B); Patients with multivessel coronary artery disease may have been undergoing treatment successfully vessel with non-target devices approved up to and including the index procedure, but before the index treatment of the target vessel. Any vessel or target lesion not to be treated during the index procedure, can not be located in unprotected left main trunk, ostium, bifurcation or venous grafts or with chronic total occlusion (CTO), severe calcification or angiographic evidence of thrombus from somehow requires performing atherectomy or thrombectomy pretreatment techniques other than balloon angioplasty; Target lesion located in a native coronary artery; Target lesion 15mm in length by visual estimate (cohort A); The target lesion (maximum length of 20 mm by visual estimation) is covered by a single stent Cronus at most 23 mm long (Cohort B); The reference vessel diameter must be more or equal 3.0 or and less or equal 3.5 mm according to visual estimation. The vessel diameter should be measured after the procedure predilatation and after intracoronary administration of nitroglycerin on suspicion of spasm; Stenosis of the target lesion more or equal 50% and less than 100% according to visual estimation.	"Pregnant or lactating patients and are planning to become pregnant in the period of 1 year after the index procedure. Women of childbearing potential should have a negative result on a pregnancy test performed within 7 days before the 
index procedure; Patient with known diagnosis of acute myocardial infarction (AMI) within 72 hours prior to the index procedure (increased concentration of troponin or CKMB more or equal 2 times the upper limit of normal) or more than 72 hours prior to the index procedure and the absence of return of CK and CKMB to within normal limits at the time of the procedure; The patient has clinical symptoms consistent with new AMI, as prolonged chest pain not responsive to the administration of nitrate; Impaired renal function or patients on dialysis; Platelet count less than 100,000 cells/mm3 or more than 700,000 cells/mm3 or a WBC count less than 3,000 cells/mm3; 
Patient with a history of bleeding diathesis or coagulopathy or in which antiplatelet therapy and / or anticoagulant is contraindicated; Any patient undergoing organ transplant waiting list or to perform organ transplant; Patient with another disease or known substance abuse. History that can impair adherence to protocol, confound the interpretation of data or is associated with limited life expectancy; Patients with known hypersensitivity or contraindication aspirin, heparin / bivalirudin, clopidogrel / ticlopidine, prasugrel, cobalt and chromium, sirolimus and / or sensitivity to contrast that can not be adequately premedicated; Patient with cardiogenic shock; Patients with unstable cardiac arrhythmias causing hemodynamic instability; Patient with extensive peripheral vascular disease that prevents the insertion of 6 Fr sheath safely; Any significant disease that in the opinion of the investigator, may interfere with the patient&apos;s participation in the study; Current participation in another study of a drug or device or inclusion in another study of a drug or device during follow up; 

Angiographic exclusion criteria: 
Coronary artery disease in the left main trunk unprotected stenosis &gt; or =  50%; Ostial lesion; Total occlusion of the target vessel (TIMI flow 0); Lesion (s) calcified target (s) that can not (m) be submitted (s) to the pre-dilatation with success; Target lesion is inadequate to release excessive tortuosity and stenting; Angiographic evidence of thrombus in the target lesion; Target bifurcation lesion with lateral branch diameter &gt; or = 2.0 mm (either stenosis in the main vessel and the side branch greater or just the latter) that requires intervention on the affected side branch; Significant stenosis (&gt; 50%) proximal or distal to the target lesion can not be covered by the same stent; Diffuse disease distal to the target lesion with loss of flow; Ejection fraction of the left ventricle (LVEF) &lt; or = 30% (LVEF should be measured one month before the index procedure); Pretreatment with devices other than the balloon; Previous stent 10mm target lesion; Intervention (PCI or surgical) of another lesion performed within 6 months before or planned within 30 days after the index procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-35bkzc	Web-based intervention to Reduce Alcohol Abuse among nightclub patrons	Recruitment completed	Intervention	2015-02-05	<NULL>	<NULL>	382	Consumption patterns of alcohol and other drugs &quot;nightclubs&quot;: Epidemiology, Ethnography and Intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-01	Universidade Federal de São Paulo	Centro Brasileiro de Informações sobre Drogas Psicotrópicas - CEBRID	https://ensaiosclinicos.gov.br/rg/RBR-35bkzc	<NULL>	Both sexes; above 18 years; be in line for one of the nigthclub selected for the representative sample, by probability proportional to size, the night of the collection of survey data portal	Extreme intoxication at the exit of the nightclub; be less than 18 years; not give consent for participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-4mnv5g	Randomized Controlled Trial of the School Prevention Program for drug Unplugged (#Tamojunto) among Brazilian adolescents	Recruitment completed	Intervention	2015-02-06	<NULL>	<NULL>	383	Evaluation of the implementation of school prevention program s to drug use for children and adolescents (Randomized controlled trial)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-18	Universidade Federal de São Paulo - UNIFESP	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4mnv5g	<NULL>	Being a student enrolled in grade 8 (old 7th grade) of one of the public schools randomly selected from the list of INEP, in São Paulo, Florianopolis, Fortaleza, Tubarão, São Bernardo do Campo, Brasilia and consent to respond to the pre and post-test questionnaire	Questionnaires without adequate codes; Students with cognitive impairment; Refusal in completing the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-2tjrgb	Evaluation of the implementation of school prevention programs to drug use for children and adolescents	Data analysis completed	Intervention	2015-02-06	<NULL>	<NULL>	384	Evaluation of the implementation of school prevention programs to drug use for children and adolescents	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Federal de São Paulo - UNIFESP	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2tjrgb	<NULL>	Schools listed by the Secretary of Education of the state of São Paulo and Santa Catarina; schools that did not have any prominence in relation to drug use by students or explicit traffic around; schools without formal programs to prevent drug use in progress	Student who not consented to fill the pre and post test questionnaires about their drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5bxqm5	Evaluation of the use of a nasal spray containing a small amount of seawater, after nasal surgery and its impact on improving the quality of life of patients	Recruiting	Intervention	2015-02-10	<NULL>	<NULL>	385	Evaluation of the use of a nasal spray solution of sodium chloride 0.9% in the immediate postoperative septoplasty and turbinecotomy and its impact on quality of life of the patient	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2014-05-30	Hospital IPO - Hospital Paranaense de Otorrinolaringologia	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-5bxqm5	<NULL>	Both sexes; between 18-65 years; indication for surgery septoplasty and inferior bilateral turbinectomy with dislocation of the turbinate; agreement to abide by the procedures and requirements of the test and attend to the Office (s) day (s) and time (s) given (s) for the evaluations	"Use of other nasal decongestant; use of analgesics and corticosteroids not described in the protocol; hypersensitivity (allergy) to components of the formula; use of topical medication in the nasal region; pregnant and lactating women; drinking alcohol during treatment; another surgery associated; 
Use of Gelfoan; packing and splints; 
Patients who have had surgery under general anesthesia;  other medical conditions considered by the investigator as reasonable for the disqualification of the individual participate in the study; postoperative complications (septal hematoma, heavy bleeding or tamponade requiring return to the operating room or infection)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-9r25zm	Evaluation of postural balance in older adults with Mild Cognitive Impairment	Recruitment completed	Observational	2015-02-10	<NULL>	<NULL>	386	Evaluation of static and dynamic balance in elderly patients with Mild Cognitive Impairment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-02-02	Faculdade de Medicina de Ribeirão Preto - FMRP-USP	Faculdade de Medicina de Ribeirão Preto - FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-9r25zm	<NULL>	"Healthy volunteers and with mild cognitive impairment, both of genders; aged between 65 and 75 years; literate (minimum education of four years of formal education), present good understanding, able to identify colors; accomplish all test items Short Physical Performance Battery (SPPB).

 To define the diagnostic groups were included:
 Volunteers with a clinical diagnosis of mild cognitive impairment; predominantly mnemonic function (amnestic Mild Cognitive Impairment of type); without impairment of functional capacity; seen at the Hospital das Clinicas da USP.
 Cognitively healthy volunteers: no evidence of cognitive or functional second clinical and neuropsychological impairment."	Volunteers with metal devices in the body and pacemakers; history of dementia or depression; cognitive changes secondary to other degenerative diseases such as Parkinson&apos;s disease and stroke; presence of other neurological diseases liable to interfere in cognition or mobility (Parkinson&apos;s disease, Multiple Sclerosis, Huntington&apos;s Disease, epilepsy, head injury) and sensorimotor and / or vestibular sequelae; severe clinical disease and adequate control off as hypertension, diabetes mellitus, chronic obstructive pulmonary disease, heart failure, kidney failure, liver failure; visual and auditory impairment uncorrected; presence of any orthopedic condition or severe rheumatologic or without control of symptoms as reporting pain, discomfort or recent surgery of the lower limbs, and other difficulties that could hinder the accomplishment of assessments; complaints of dizziness, vertigo, or history of frequent falls; significant decrease in performance in daily activities; using devices for walking (such as a cane, crutch, walker or wheelchair); refusal to signing the informed consent form (ICF) or participate in the evaluations proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-29kgz5	Exercices for pelvic muscles before and after pelvic organs prolapse surgery	Recruiting	Intervention	2015-02-10	<NULL>	<NULL>	387	Training of Pelvic Floor Muscles before and after Pelvic Organs Prolapse (POP) surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-29kgz5	<NULL>	Age between 35 and 80 years old; clinical complaints consistent with genital prolapse; medical indication for vaginal surgery to repair the anterior, apical and posterior defects, POP stages II, III and IV evaluated by the Pelvic Organ Prolapse Quantification (POP-Q); absence of prior correction of pelvic organ prolapse pelvic surgery; absence of present vaginal and urinary infections; women literate; absence of uncompensated endocrine disorders that may interfere with sexual function (hypothyroidism)	"Use of hormone  therapy;immediate complications related to the surgical correction of POP not resolved within 40 days after surgery (pain and infection vaginal vault); late complications not directly related to the surgery (post-anesthesia headache); women who do not accept any of the reviews make proposals;
women who do not meet the previous schedule of ratings of physical therapy and evaluations"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7sqj78	Effects of noninvasive mechanical ventilation in pulmonary function and functional capacity after cardiac surgery:A Randomized Controlled trial	Recruitment completed	Intervention	2015-02-10	<NULL>	<NULL>	388	Effects of noninvasive ventilation with positive pressure in the pulmonary function, functional capacity and inflammatory response after coronary artery bypass grafting: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-04	Univerdidade Federal de São Paulo	Hospital Santa Rosa	https://ensaiosclinicos.gov.br/rg/RBR-7sqj78	<NULL>	Both gender, age between 35 and 75 years; proven coronary disease by coronary angiography; Surgery elective CABG with CPB and use of the LITA; ventricular ejection fraction greater than 50%; Absence of acute pulmonary disease or chronic, patients who, after surgery, keep in spontaneous ventilation on the first day after surgery.	Inability to perform spirometry; Presence of acute or chronic lung disease; Required urgent surgery;  Chronic inflammatory disease; Kidney or liver disease; Patients using corticosteroids, acetyl salicylic acid or other anti-inflammatory drugs; Clinical or laboratory evidence of infection; Morbid obesity; Hemodynamic instability at the time of spirometry; Change the surgical technique during surgery; Death during surgery or before the fifth day after surgery; Patients who remain in prolonged mechanical ventilation for more than twelve hours; Request of the patient or legal guardian at any time during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-6v4y3k	Transcranial current stimulation for childrens with cerebral palsy	Recruiting	Intervention	2015-02-11	<NULL>	<NULL>	389	Transcranial direct current stimulation associated with upper limb functional training for childrens with spastic hemiparetic cerebral palsy:a randomized controlled double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-10	Associação Educacional Nove de Julho	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6v4y3k	<NULL>	The criteria for inclusion will be children with  spastic hemiparetic cerebral palsy  come from school of physiotherapy clinics of UNINOVE which have, diagnosis of spastic hemiparetic cerebral palsy;functional classification of upper limbs as levels I, II or III for MACS; have age between 6 and 16 years old;have degrees of understanding and cooperation that are compatible with the achievement of the proposed activities;the legal guardians for the children, agree with your participation in the study through the signing of the informed consent already approved by the COEP UNINOVE	Will be excluded childrens who:have  performed surgery or neurolíticos locks procedures in the upper limb paretic, in the last 12 months before the beginning of the training sessions;have structured deformities with Orthopedic Surgical indications;have epilepsy;have metal implant in the brain or hearing aids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-24ydf6	Functional impact of Foot Orthoses in rheumatoid arthritis feet	Recruitment completed	Intervention	2015-02-12	<NULL>	<NULL>	390	Kinect and functional impact of foot orthoses in rheumatoid arthritis feet	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-05	Centro Universitário Estacio da Bahia - FIB	Cristiano Sena da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-24ydf6	<NULL>	Volunteers with Rheumatoid Arthritis; both genders; aged between 18 and 75 years; ability to walk with or without the use of assistive devices (cane, crutch or walker); agree to participate by signing the Informed Consent Form (ICF).	Volunteers with Rheumatoid Arthritis presenting neurological disease and disability to walk; cognitive impairment; lesions on the skin of the feet; surgery on lower limb; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-3q8j43	A study to evaluate both the efficacy and safety profile of CP 690,550 in patients with moderately to severely active ulcerative colitis	Recruiting	Intervention	2015-02-17	<NULL>	<NULL>	391	A multicentre, randomized, double-blind, placebo controlled, parallel group study of oral CP 690,550 as an induction therapy in subjects with moderate to severe ulcerative colitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-21	Hospital de Clínicas de Porto Alegre (Centro Coordenador)	Laboratórios Pfizer Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q8j43	<NULL>	"Subject must be at least 18 years of age; males and females with a documented diagnosis of ulcerative colitis (UC) at least 4 months prior to entry into the study; subjects with moderately to severely active UC based on Mayo score criteria; subjects must have failed or be intolerant of at least one of the following treatments for UC: corticosteroids (oral ou intravenous), azathioprine or 6 mercaptopurine (6MP), anti TNF alpha therapy (infliximab ou
adalimumab)."	"Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, or clinical findings
suggestive of Crohn&apos;s disease; subjects with disease limited to distal 15 cm; subjects without previous treatment for UC (ie, treatment naive); subjects displaying clinical signs of fulminant colitis or toxic megacolon."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7jkbyg	Vestibular Rehabilitation assessment in elderly with vertigo	Recruiting	Intervention	2015-02-18	<NULL>	<NULL>	392	Vestibular Rehabilitation assessment in elderly patients with Benign Paroxysmal Positional Vertigo (BPPV)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-05	UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE	UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE	https://ensaiosclinicos.gov.br/rg/RBR-7jkbyg	<NULL>	Patients from both gender, had to be 65 years or older with clinical diagnosis of chronic subjective or objective BPPV in the posterior canal (minimum 6 months). They should agree to participate in the study according with the consent term informed. The patients will be referred from the Otoneurology ambulatory of the Hospital Universitario Onofre Lopes, and other public or private services of medical specialties who treat patients with dizziness complaint in Natal/RN city.	Patients with BBPV involving anterior or horizontal canal ; Other vestibular disorders ; neurological dysfunction, severe somatosensory and orthopaedic problems (osteoarthritis of knee or lower extremity deformity) will be excluded to eliminate confounding factors affecting balance performance; Uncontrolled metabolic diseases; Unable to understand and answer a simple verbal command; Previously underwent both ORM or Vestibular Balance Therapy; individuals who took vertigo medication during the study, and patients with neck disturbances that prevent them from performing the maneuver will be also excluded; Performing some physical activities such as: muscle strengthening exercises, pilates, yoga or high intensity aerobic exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-82y4dz	Evaluation of the skin firmness and elasticity	Data analysis completed	Intervention	2015-02-18	<NULL>	<NULL>	393	Evaluation of the skin firmness and elasticity	<NULL>	4, single-arm-study, single-blind	4	<NULL>	<NULL>	<NULL>	2014-05-15	KOSMOSCIENCE CIENCIA E TECNOLOGIA COSM IMP EXP LTDA	Herbarium Laboratório Botânico Ltda	https://ensaiosclinicos.gov.br/rg/RBR-82y4dz	<NULL>	Female volunteers, aged between 18 and 60 years, with skin phototype I to IV and intact skin in the region of the test; signs of sagging in the area evaluated; good physical condition and mental health; agreement not to use any topical products on the arms between the 48 h period before the day of the beginning of the study until the end of this; signing the Informed Consent Form ICF.	"Skin marks in the experimental area that interfere with evaluation of possible skin reactions, pigmentation disorders , vascular malformations , scars , increased hairiness , freckles and warts aplenty, sunburn ; dermatoses active local or widespread , that may interfere with results of the study .
Pregnant or lactating ; a history of allergic reactions , irritation or discomfort to intense feelings of topical products : cosmetics or medicines ; history of atopy ; intense sun exposure or tanning session up to 15 days before the initial evaluation or during the study prediction of intense sun exposure during the study ; body dermatological aesthetic treatment or up to 03 weeks before selection, such as : mesotherapy , carboxiterapia and body peels.
Use of the following medications topical or systemic use : immunosuppressants , antihistamines , NSAIDs and corticosteroids to 2 weeks prior to or during the study period ; treatment with Vitamin A acid and / or its derivatives orally or topically for 1 month prior to study initiation .
Be participating in another study or have participated in another study with cosmetic until a week before the study inclusion ; ingestion of nutritional supplements that can influence the results of the study ; any condition which , in the opinion of the investigator , may compromise the evaluation of the study ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7d9dth	Comparison between ventilation with a pressure and with two positive pressure in the nostrils of premature newborns	Data analysis completed	Observational	2015-02-19	<NULL>	<NULL>	394	Comparison of nasal CPAP and nasal CPAP with a Cycling Time in preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-17	Universidade de Franca	Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7d9dth	<NULL>	Infants born at a gestational age of less than 37 weeks and weighing less than 2,500g, who received noninvasive ventilation.	Newborns with congenital malformations, abdominal post-surgery and neonatal infection as well as term newborns	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-8xj48n	Urinary incontinence, sexual function and pelvic floor muscle strength during pregnancy and postpartum period	Data analysis completed	Intervention	2015-02-19	<NULL>	<NULL>	395	Perineal care during pregnancy and postpartum period: prevention and morbidity related to pelvic floor muscle strength, sexual function and urinary continence	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-21	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xj48n	<NULL>	Having urinary incontinence during the current pregnancy, until the 24th week; Not having undergone surgery urogenital prior; Not having diseases that can interfere with pelvic floor muscle strength (prolapse of pelvic organ, neurological diseases, diabetes, pelvic injury or spinal); Be 18 years old or more; Having completed elementary school; Having difficulty in understanding Portuguese language or in communication.	Having multiple pregnancy; Having obstetric complications during pregnancy (haemorrhagic syndromes, isthmus-cervical insufficiency, premature labour, recurrent urinary tract infection); Offer resistance against the insertion of the perineometer in the vagina; Not adherence to complete physiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-69yzkb	Effect of periodontal treatment on blood vessels and inflammation in type 2 diabetics with gum disease	Recruiting	Intervention	2015-02-19	<NULL>	<NULL>	396	Effect of periodontal treatment on endothelial and microvascular functions and gingival fluid and blood levels of immunoinflammatory biomarkers in type 2 diabetics with severe periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-11	Hospital Universitário Pedro Ernesto	Faculdade de Odontologia da UERJ	https://ensaiosclinicos.gov.br/rg/RBR-69yzkb	<NULL>	Patients with severe periodontitis; both genders; more than 18 years old; at least 12 teeth; type 2 diabetes mellitus	HIV; immunological and chronic inflammatory diseases; prolonged usage of medications 6 months before the start of the study as antibiotics; cortisone; antihistamine; hormones; and others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-6rtcvb	Effect of neural mobilization and self-mobilization in the flexibility of the hamstrings in elderly women	Data analysis completed	Intervention	2015-02-20	<NULL>	<NULL>	397	Effect of neural mobilization and automobilization in hamstring flexibility in older	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Associação Teresinense de Ensino SC LTDA	Centro de Convivência da Terceira Idade	https://ensaiosclinicos.gov.br/rg/RBR-6rtcvb	<NULL>	The elderly From 60 years; attendance NAS activities developed in the Social Center of the Third Age ; Consent to Participate in Study.	Presence of severe joint deformities or traumatic orthopedic origin; acute inflammatory diseases ; Deep vein thrombosis ; neurological signs, lack of cooperation in the procedures that were performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-8rz4yq	Effects of two bodybuilding programs in health and physical performance	Recruitment completed	Intervention	2015-02-23	<NULL>	<NULL>	398	Effects of two periodized resisted training programs on markers of metabolic syndrome and functional fitness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Departamento de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8rz4yq	<NULL>	Age between 40 and 60 years; have metabolic syndrome; no regular physical activity or strength training in the last 6 months.	Use of drugs or medicines that are not related to the metabolic syndrome factors; amenorrhea; presence of inflammation or infection; musculotendinous or osteoarticular injuries in the upper limbs, lower limbs or column; respiratory diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-5pj5bb	Effects of mate tea consumption on muscle strength recovery and indicators of inflammation and damage caused by free radicals after exercise	Recruiting	Intervention	2015-02-23	<NULL>	<NULL>	399	Effects of mate tea (ilex paraguariensis) consumption on muscle strength and concentration of inflammatory and oxidative stress markers after eccentric exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-12	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5pj5bb	<NULL>	Healthy male, 19 to 30 years old; physically active.	Athletes; participation in formalized resistance or aerobic training programs in the previous three months preceding the study; smoking; having any disease, infection, or inflammatory processes; history of upper limb injury; and using any medication, ergogenic aids, herbal supplements, or vitamin/mineral supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-5q5nz4	Effects of running technique modification	Not yet recruiting	Intervention	2015-02-23	<NULL>	<NULL>	400	Effects of Running Technique Modification on lower limb kinematics and muscle activation in runners with and without Patellofemoral Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Federal de São Carlos/UFSCar	Universidade Federal de São Carlos/UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-5q5nz4	<NULL>	"Rearfoot strikers, familiar with treadmillrunning and run a minimum of 20 km/wk at least 3 months prior to study enrollment
All must have previous anterior or retropatellar pain in at least three of these activities: up/down stairs, squatting, running, kneeling, jumping and after seated for long periods; insidious onset of symptoms unrelated to traumatic incident and persistent for at least three months during the running activity; presence of pain after patellar compression and usual pain in the last week of at least 3 cm on the visual analog scale of 10 cm."	Signs or symptoms of: meniscal or intra-articular pathology; previous knee joint ligament injuries; ligamentous laxity; sign of patellar apprehension; Osgood-Schlatter or Sinding-Larsen-Johansson syndrome; lumbar spine,  hip or ankle pain; prior patellar dislocation; evidence of knee joint effusion; lower limb surgery; cardiovascular or neurological  diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-45rdh2	Effect of Therapeutic Touch for preventing injuries in the feet of people with diabetes	Recruitment completed	Intervention	2015-02-24	<NULL>	<NULL>	401	Effect of Therapeutic Touch for prevention of Diabetic Foot	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Alfenas	Conselho Nacional de Desenvolvimento Cientítfico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-45rdh2	<NULL>	Volunteer with Diabetes Mellitus Type 2 diagnosed for at least five years; of both sexes; registered in HIPERDIA; medical care in the unit; over the age of 18 years; have at least one risk factor for impaired skin integrity, according to established nursing diagnosis &quot;risk of impaired skin integrity&quot; (NANDA,2013).	Volunteers with cognitive disabilities; presence of foot ulcers; presence of amputations of the lower limbs; presence of thrombosis; uncontrolled hypertension; in other unconventional treatment modality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-2h9smt	nterventions to enhance infection by the tuberculosis agent identification and treatment prescription in persosn without active disease.	Recruiting	Intervention	2015-02-24	<NULL>	<NULL>	402	Public health actions to enhance latent TB infection treatment.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-02	Rio de Janeiro Secretaria Municipal de Saúde	Centro de Pesquisas Aggeu Magalhães (CPqAM)	https://ensaiosclinicos.gov.br/rg/RBR-2h9smt	<NULL>	"In the first phase (diagnosis of the bottlenecks)
Subjects with active pulmonary tuberculosis and  their household contacts aged 18 or over; health care workers who assist tuberculosis patients

In the second phase (intervention):
Household contacts of patients with active pulmonary tuberculosis; any age; health care workers who assist tuberculosis patients"	Only in the first phase: not agreement to participate or sign the informed consent. No associated co-morbidity prevents the participant to take part in the study (mainly concerning active tuberculosis screening).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-78rn72	Evaluation cost of light apparatus for early detection of oral cancer in Goiás	Recruiting	Observational	2015-02-25	<NULL>	<NULL>	403	Technology assessment in the implementation of a screening and matrix model of oral cancer in Goias state: study of cost-effectiveness of visual inspection and inspections with florescence	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-08-15	Faculdade de Odontologia da Universidade Federal de Goiás	Universidade de Malmö	https://ensaiosclinicos.gov.br/rg/RBR-78rn72	<NULL>	Individuals of both genders; smokers who use cigarretes since 1 month ago at least; consuming alcoholic drinks at least once per week; with sun exposure over 2 hours per day; history of sexually transmitted disease; over 40 years old	Individuals who do not accept signing the informed consent, or if they fail any of the conditions described in the inclusion criteria, or do not allow the assessment of the oral cavity under white light or under the violet light	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-2wpryx	Effect of almond consumption baru on the levels of cholesterol, free radicals and inflammation in overweight women	Recruitment completed	Intervention	2015-02-25	<NULL>	<NULL>	404	Effect of almond consumption baru on the lipid profile, oxidative stress and inflammatory women overweight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-31	Hospital das Clínicas - Universidade Federal de Goiás	Faculdade de Nutrição - Fanut/UFG	https://ensaiosclinicos.gov.br/rg/RBR-2wpryx	<NULL>	Female volunteers; diagnosis of overweight or obesity; aged between 20 and 60 years, who receive care in outpatient clinics of general nutrition and nutrition Endocrinology, Hospital das Clinicas, Federal University of Goiás	Volunteer smokers, pregnant or lactating; volunteers with prescription diets for weight reduction; with Body Mass Index below 25 kg/m2 or 40 kg/m2; diagnosis of autoimmune diseases, hepatic or renal diseases; history of drug abuse or alcohol; use of dietary supplements; volunteers who are receiving medications a week before the study or during the performance; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-39z9pb	study to the evaluate non-inferiority Compared two local anesthetic for orthopedic procedures on the lower limbs	Not yet recruiting	Intervention	2015-02-25	<NULL>	<NULL>	405	Phase III study to evaluate the noninferiority of levobupivacaine with excess 50% (levobupivacaine S75: R25) heavy compared to racemic bupivacaine (bupivacaine S50: R50) heavy in spinal anesthesia for lower limb orthopedic procedures	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-07-01	Faculdade de Medicina do ABC	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-39z9pb	<NULL>	Patients who agree to participate in the study and signed the consent form, both sexes, aged between 18 and 80 years inclusive, ASA I or ASA II with indication for spinal anesthesia for orthopedic surgery of the lower limbs	Absolute or relative contraindications to spinal anesthesia ; intolerance or hypersensitivity to local anesthetics or components of the formula , spinal cord injuries , peripheral neuropathy or other neurological disorders that lead to disturbances of sensation and / or motor function , dementia , mental retardation and other important cognitive changes ; obesity with body mass index ? 35 or difficulty in executing the puncture ; anatomical difficulty column in the Investigator&apos;s opinion , previous surgery of the spine ; polytrauma ; tattoo at the puncture site , alcoholism , substance abuse , history severe Stevens- Johnson anaphylactic reactions, changes in safety tests ( INR &gt; 1.4 , platelet count &lt; 100,000 mm3 , blood glucose &gt; 200mg/dl , bradyarrhythmias , heart block , frequent premature ventricular beats or saved evident on ECG ) ; participation in any clinical trial within the 12 months preceding their inclusion , pregnancy or lactation, any other condition that , in the Investigator&apos;s opinion , may lead to increased risk to the patient.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-9vmkcb	Duration of analgesia of the perineum with ice packs after childbirth	Recruitment completed	Intervention	2015-02-26	<NULL>	<NULL>	406	Duration of the analgesic effect of cryotherapy on perineal pain after childbirth: clinical trial	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-12-11	Universidade de São Paulo	Amparo Maternal	https://ensaiosclinicos.gov.br/rg/RBR-9vmkcb	<NULL>	"equal to or greater than 18 years old; 
at least one vaginal delivery prior to the current; 
Current normal delivery; 
term pregnancy (between 37 and 41 weeks and 6 days gestational age); 
single live fetus and cephalic presentation; 
not have received the analgesic prior to study entry three hours; 
be within 6 to 24 h post-partum; 
not have received spinal and / or epidural anesthesia; 
refer largest perineal pain or equal to 3 on a scale at the time of study enrollment; 
have had RN in good clinical condition; 
not show clinical or obstetric complications; 
not present difficulties of communication or understanding of the English language."	Receiving analgesic or anti-inflammatory until 120 min after the use of cryotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7vr7xs	Definition of a standard length of nasogastric feeding tube in adults: randomized clinical trial	Recruitment completed	Intervention	2015-02-26	<NULL>	<NULL>	407	Definition of a standard length of nasogastric tube in adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-06	Hospital das Clínicas da Unicamp	Faculdade de Enfermagem - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7vr7xs	<NULL>	Adult patients; with aged over 18 years; of both sexes; with medical prescription of nasogastric feeding tube.	Are excluded from the study patients with prescribed nasogastric tube for drainage, with mechanical obstruction of the Digestive System and morphological abnormalities of the gastrointestinal tract, with prior gastric surgery, morbidly obese, with diseases that may alter the external abdominal anthropometric measures. It will be considered an absolute contraindication for the introduction of nasogastric tube, patients who experience recent nasal surgery, coagulation disorders, esophageal varices, cauterization or recent ligation of esophageal varices, alkaline intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-8bvqz2	Effect of nursing interventions using the telephone	Recruiting	Intervention	2015-02-26	<NULL>	<NULL>	408	Effectiveness of nursing interventions using the telephone	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-24	Escola de Enfermagem da Universidade de São Paulo-EEUSP	Escola de Enfermagem da Universidade de São Paulo-EEUSP	https://ensaiosclinicos.gov.br/rg/RBR-8bvqz2	<NULL>	Being a family caregiver of a person with chronic illness; aged over 18 years; reading and writing,to have a longer than a month taking care of the family; to  have telephone service, to have a nursing diagnosis Caregiver Role Strain	Caregiver with cognitive impairment, assessed by the Mini Mental State Examination (MMSE) test;to have limitations for speech and hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-96kvrq	Efficacy and safety of corticosteroids use in severe pulmonary inflammation in children	Recruiting	Intervention	2015-03-02	<NULL>	<NULL>	409	Phase II, randomized, placebo-controlled, double-blind clinical trial to evaluate the effects and safety of infusion of low-doses of Methilprednisolone in early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in children	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto D&apos;Or de Pesquisa	Instituto de Puericultura e Pediatria Martagão Gesteira - Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-96kvrq	<NULL>	Pediatric patients in mechanical ventilation; diagnosis of ALI/ARDS within the first 72 hours based on the current literature criteria; informed consent properly signed; both genders; age range from 29 days to 18 years.	ALI/ARDS with more than 72 hours of diagnosis; failure to obtain written informed consent  to participate in the study; condition requiring &gt; 0.5mg/Kg/day of prednisone equivalent; primary or secondary neuromuscular dysfunction; patients using aminoglycosides combined with neuromuscular blockers; cardiopulmonary arrest within 7 days or anytime during present hospitalization prior to enrollment; irreversible cessation of all brain function; immunosuppression acquired or congenital, including HIV+ status; history of bone marrow or solid organ transplantation; current malignancy, neutropenia, receiving cytotoxic therapy for any reason, and acute burn injury; severe chronic liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-5tv5vt	Physical exercise for subtle memory problems	Recruitment completed	Intervention	2015-03-04	<NULL>	<NULL>	410	Predictor factors of the cognitive outcome in subjects with mild cognitive impairment submitted to aerobic physical exercise	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5tv5vt	<NULL>	Patients with mild cognitive impairment	Individuals with cognitive decline of sufficient intensity for the diagnosis of dementia will be excluded, as well as individuals with psychiatric disorders in activity (not in remission now). Other exclusion criteria include clinical illness or physical disability that prevents the achievement of aerobic exercise, auditory and visual impair cognitive assessment, scores on the questionnaire functionality Pfeffer greater than four and illiteracy. Here we characterize illiteracy to less than one year of formal education and inability to read the phrase &quot;Close your Eyes&quot; mini mental state examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7btt63	Evaluation of empowerment in education group for Diabetes	Data analysis completed	Intervention	2015-03-04	<NULL>	<NULL>	411	Evaluation of the process of empowerment group education in Diabetes in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7btt63	<NULL>	Patients of Health Basic Units diagnosed with type 2 diabetes confirmed by medical records, who participated in at least three education group meetings, as a minimum age of 30 and maximum of 80 years, of both sexes and who signed the Terms of Consent.	Patients from Basic Health Units with Type I Diabetes diagnosis; not attend at least three group education meetings; users with psychiatric disorders or complications of the disease that affect the ability to respond to self-care tools and empowerment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-6gphkr	"CQAB149BAR01 - 24-week study to assess which treatment is safer and bring more benefits to patients with COPD (Chronic Obstructive Pulmonary Disease)
combination budesonide / indacaterol vs fluticasone /
salmeterol"	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	412	"CQAB149BAR01 - 24-week study to evaluate efficacy and safety of the
combination budesonide / indacaterol vs fluticasone /
salmeterol in patients with COPD"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-02-28	Novartis Biociências S.A.	Novartis Biociências S.A.	https://ensaiosclinicos.gov.br/rg/RBR-6gphkr	<NULL>	Patients both genders, age greater than 40 years in outpatient treatment with a diagnosis of COPD in groups C and D, according to the GOLD with post-bronchodilator FEV1 &lt;60% guidelines and 30% predicted, FEV 1 / FVC post-bronchodilator &lt;0.7; smoking for at least 10 pack-years (defined as 20 cigarettes per day for 10 years or 10 cigarettes per day for 20 years and so on); smokers and ex-smokers are eligible; history of at least one exacerbation of COPD.	Patients requiring oxygen therapy for chronic hypoxemia (excluding acute exacerbation of COPD), typically with oxygen&gt; 15 h per day; COPD exacerbation within 6 weeks prior to visit 1 or between visits 1 and 2 or the presence of infection of the upper or lower respiratory tract infection during the screening period (Visit to 2) shall be permitted to a new screening after a minimum and 6 weeks after resolution of the episode; Pulmonary disease associated, for example, (except confirmed by chest radiography and no longer active) pulmonary tuberculosis or clinically significant bronchiectasis, sarcoidosis, interstitial lung disease or pulmonary hypertension; known diagnosis of deficiency of Alpha-1 Antitrypsin; Pulmonary lobectomy; lung volume reduction or lung transplantation; participation in the active phase of a program of supervised pulmonary rehabilitation; Asthma history marked by (but not limited to):.. onset of respiratory symptoms (coughing, wheezing, shortness of breath) suggestive of asthma before age 40 and history of a diagnosis of asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7n2d2f	Cranial electrical current associated with gait training on a treadmill in people who have had a stroke.	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	413	Transcranial direct-current stimulation combined with treamill training for Stroke:a randomized, controlled, duble-blind, clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Conselho Nascionla de Pesquisa (CNPq)	Conselho Nascionla de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-7n2d2f	<NULL>	Patients with a diagnosis of stroke. Both sexes. Age between 50 and 70 years. Able to walk independently.	Patients with stroke who have joint pain in the lower limbs that compromise the function. What have contractions in the joints of the lower limbs. With cardiovascular and cognitive changes that make it impossible to perform the tests. With metal implants in the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-6hmfk8	Study to evaluate the safety and efficacy of TAVR device.	Not yet recruiting	Intervention	2015-02-17	<NULL>	<NULL>	414	The TAVR feasibility Study_a pilot non-randomised single-arm clinical study to evaluate the feasibility and safety of the valve medical TAVR product in patients with severe symptomatic aortic stenosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto Dante Pazzanese	Instituto Dante Pazzanese	https://ensaiosclinicos.gov.br/rg/RBR-6hmfk8	<NULL>	"Age &gt; or = 18 years; Understand the implications of participating in the study and provide informed consent; Be suitable candidate for surgical aortic valve replacement; Comply with specified follow-up evaluation and be contacted by telephone; Present severe aortic stenosis: AVA &lt; or =  0.8 cm2 (or AVA index &lt; or = 0.5cm2/m2) AND PV &gt; 4 m/sec or mean
gradient &gt; 40 mmHg; Present cardiac symptoms: &gt; or =  NYHA Class II; Have co-morbidities associated with an increased surgical risk profile: (1) EuroSCORE &gt; or = 20% or STS &gt; or = 8% or (2) other high surgical risk factors as determined by the Heart Team (e.g. porcelain aorta, extreme frailty, liver disease, etc.); Have aortic annulus diameter &gt; or = 22 mm and &lt; 26 mm, assessed by both trans-thoracic echocardiography and by CTA; Have peripheral vessels (common femoral and iliac arteries) of acceptable size, tortuosity, and calcification to accommodate the 12Fr catheter system"	"Congenital unicuspid or bicuspid valve, or noncalcified aortic valve; Mixed aortic valve disease (aortic stenosis and aortic regurgitation with predominant aortic regurgitation &gt; or = 3+); Active or recent (within 6 months) endocarditis;  Other active infections; Recent MI (&lt; or = 1 month); Any therapeutic invasive cardiac procedure (except BAV) performed within 30 days of the index procedure; Prosthetic heart valve in any position;  Severe (&gt; 3+) mitral regurgitation; Blood dyscrasias as defined: leukopenia (WBC&lt;3000/mm3), acute anemia (Hb &lt;8mg%),
thrombocytopenia (platelet count &lt;50,000 cells/mm&apos;), history of bleeding diathesis or coagulopathy; Untreated clinically significant coronary artery disease requiring revascularization; Hemodynamic instability requiring inotropic support or mechanical support devices; Hypertrophic cardiomyopathy with or without obstruction (HCM); Severe ventricular dysfunction with left ventricular ejection fraction (LVEF) &lt;20%; Echocardiographic evidence of intracardiac mass, thrombus or vegetation; Active peptic ulcer or upper GI bleeding within the prior 3 months; Known hypersensitivity or contraindication to aspirin, heparin, or clopidogrel, or sensitivity to contrast media (which cannot be adequately premedicated); Recent (&lt;6 months) cerebrovascular accident (CVA) or transient ischemic attack (TIA); Renal insufficiency (creatinine &gt; 3.0) and/or end stage renal disease requiring chronic dialysis; Severe aortic disease, including abdominal aortic or thoracic aneurysm (lumen diameter &gt; 5cm), marked tortuosity, or severe aortic arch atheroma; Aortic annulus diameter &lt;22 mm and &gt; or = 26 mm, assessed by trans-thoracic echocardiography and CTA; Peripheral vessels (common femoral and iliac arteries) NOT of acceptable size, tortuosity, and calcification to accommodate the 12Fr catheter system (&gt; or = 4mm diameter); Life expectancy &lt; 12 months due to non-cardiac co-morbid conditions; Currently participating in an investigational drug or another device study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-84xprt	The effect of non-pharmacological measures for pain relief in labor	Recruitment completed	Intervention	2015-03-09	<NULL>	<NULL>	415	Review of non-pharmacological interventions for pain relief in labor	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2013-06-01	Real e Benemérita Associação Portuguesa de Beneficência /SP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-84xprt	<NULL>	Voluntary without any clinical or obstetric disease; active phase of labor with efficient two or three in ten minutes uterine contractions and cervical dilatation minimum 3 cm; gestational age between 37 completed weeks to complete 42 weeks calculated by last menstrual period or the result of early ultrasound until the twentieth week of pregnancy; minimum age of 18 years old and maximum age of 55 years; pregnancy with single live fetus in cephalic presentation bent; Note greatest pain 5 on the pain scale	Volunteers with indication of caesarean section at admission; use of anesthesia during labor; Tobacco use less than two hours; people with mental disorders that may affect their autonomy; have ingested caffeine in the last 10 hours; use psychoactive drugs; performed less than 06 prenatal visits; use of natural or synthetic corticosteroids; used analgesics least at least 6 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-58bry9	Comparison of Calcium Use in Patients with Lack of Parathyroid Hormone, Taken in Three Different Ways: Fasting, with Water or Orange Juice, and After Breakfast	Recruitment completed	Intervention	2015-03-09	<NULL>	<NULL>	416	Comparison of the Absorption of Calcium Carbonate in Patients with Definitive Hypoparathyroidism Ingested Three Different Ways: Fasting, with Water or Orange Juice, and After Breakfast	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Faculdade de Medicina de Botucatu - Unesp	"Faculdade de Medicina de Botucatu - Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Unesp"	https://ensaiosclinicos.gov.br/rg/RBR-58bry9	<NULL>	Female, regularly followed at the outpatient thyroid neoplasms; carriers after definitive surgical hypoparathyroidism, with persistent symptoms after at least 1 year after completion of total thyroidectomy due to CDT; between 18 and 50 years of age, who had no serious illnesses and who agreed and signed the Informed Consent.	Menopause; neuromotor disorder; sequela of stroke; malabsorptive syndrome; digestive complications of the gastrointestinal tract; decompensated diabetes; severe hypertension; chronic renal failure; liver disease; malnutrition; cancer; manifest hyperthyroidism; severe chronic obstructive pulmonary disease; patients with therapy antirreabsortiva bone, or use of corticosteroids, thiazides, omeprazole and prokinetics; hat are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-472p29	Comparison of physical exercise in elderly	Data analysis completed	Intervention	2015-03-09	<NULL>	<NULL>	417	Comparison of physical exercise in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-472p29	<NULL>	Women&apos;S; between 60 and 70 years; medical statement for physical exercise; sedentary for at least 6 months	Cognitive impairment according to the Mini Mental State Examination; functional limitations in walking; the use of support devices; affirmative response regarding comorbidities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-28mjwb	Effects lasertherapy on physical exercise in elderly women.	Recruitment completed	Intervention	2015-03-11	<NULL>	<NULL>	418	Effects of low-level laser therapy on isokinetic muscle performance in elderly women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-28mjwb	<NULL>	Females; age between 60 to 70 years old; full active range of motion and no pain in the hip, knee and ankle; body mass index between 18 to 27kg/cm ²,  taking into account height and weight; active or irregularly active, second International Physical Activity Questionnaire short version.	Pain in the spine or lower limbs;  history of trauma or previous surgery in the lower limbs or spine; history of muscle injury the femoral quadriceps, coxofemoral subluxation of the joint; osteoarthritis of the hip and or knee; rheumatic, degenerative or neurological diseases;  fibromyalgia; hypertension and uncontrolled diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-4253s4	LED therapy in muscle fatigue	Recruitment completed	Intervention	2015-03-13	<NULL>	<NULL>	419	LED therapy in muscle fatigue	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-10	Universidade Camilo Castelo Branco	Areolino Pena Matos	https://ensaiosclinicos.gov.br/rg/RBR-4253s4	<NULL>	Women between 60 and 70 years of age; non-athletes; with BMI between 18.5 and 29.99 Kg/m2 who agreed to take part in the approved study after signing the consent form.	Previous lower limb and cervical surgery; degenerative systemic diseases; regular use of muscle relaxants or use at least 3 days before the test; rhabdomyolysis; neuromuscular disease, myasthenia gravis; polymyositis; asymptomatic degenerative or inflammatory joint disease in the hands, wrists, and elbows; tendinitis or tenosynovitis of the wrist extensors or flexors and fingers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-4j428f	Effects of training in the pool in balance in elderly individuals	Recruitment completed	Intervention	2015-03-17	<NULL>	<NULL>	420	Hydrotherapy in balance in elderly individuals	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Universidade Federal da Paraíba	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-4j428f	<NULL>	Elderly individuals (between 60 and 90 years) from both sexes,  sedentary, independents in the gait and daily activities.	Show dysfunction in the neurological and cardiovascular systems, cognitive alterations, diagnosis of vertigo, hearing problems or urinary infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-3rqmgh	Effect of stimulation with electrical current in fibromyalgia:randomized clinical trial	Recruiting	Intervention	2015-03-17	<NULL>	<NULL>	421	Effect of TENS in fibromyalgia:randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-17	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3rqmgh	<NULL>	Will be included patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of the IC, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-3xgjf3	Promotion of self-care for people with Diabetes	Recruitment completed	Intervention	2015-03-17	<NULL>	<NULL>	422	Consultation of nursing as a strategy for the promotion of self-care for people with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Estadual de Maringá	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3xgjf3	<NULL>	Be registered in the Basic Health Unit as a person diagnosed with Diabetes Mellitus type 2; minimum age of 40 years; both genders; have availability to attend consultations.	Do not move to the Health Unit for consultations; Cognitive impairment and \ or hearing referred by the health team.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7g5zng	Clinical efficiency of two sequences of orthodontic wires to correct crowding of the lower anterior teeth	Terminated	Intervention	2015-03-17	<NULL>	<NULL>	423	Comparison of the clinical efficiency between two wires sequences for orthodontic alignment and leveling	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Centro Universitário do Maranhão	Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-7g5zng	<NULL>	Moderate mandibular anterior crowding (3-6 mm); all teeth present in the mandibular arch, up to second molars; no prescription for extractions in the mandibular arch; no need for treatment with intermaxillary elastics, interproximal stripping, open NiTi compression springs or active labial bow; no diseases that might affect tooth movement; and significant tooth size and shape abnormalities.	Patients with a history of trauma; resorption and that, for any reason, did not visit the clinic for more than a month; whose mandibular appliance broke; who had undergone previous orthodontic treatment .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-2ht76k	Comparison of methods for masticatory function evaluation	Not yet recruiting	Intervention	2015-03-18	<NULL>	<NULL>	424	Comparison of methodologies applied to masticatory function evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Odontologia de Piracicaba UNICAMP	Faculdade de Odontologia de Piracicaba UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-2ht76k	<NULL>	Health subjects; both gender; aged from 25 to 70 years; complete natural dentition or total edentulism wearing a conventional complete denture or a implant supported mandibular dentures.	Diagnostic of caries; periodontal disease; facial malformations; severe malocclusion; posterior crossbite; anterior open bite; parafunctional habits; temporomandibular disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-686gts	The effect of psychoeducation in reducing the burden of caregivers from mental disorders	Data analysis completed	Intervention	2015-03-19	<NULL>	<NULL>	425	Effectiveness of support in psychoeducation in reducing the burden for families of patients with psychological distress	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Católica de Pelotas	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-686gts	<NULL>	Caregivers of patients attending in mental health services in the city of Pelotas with emotional overload. Caregivers whith more than 18 years old. Caregivers who living in the urban area of the city. Caregivers of both genders	Caregivers of patients attending in mental health services in the city of Pelotas with severe psychological disorders. Caregivers who have difficulty in understanding. Caregivers  under 18 years old. Caregivers who can not participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-97bztb	Program for health promotion in schools of public elementary school in the state of Rio Grande do Sul	Recruiting	Intervention	2015-03-19	<NULL>	<NULL>	426	Intervention program for health promotion in schools of public elementary school in the state of Rio Grande do Sul: clinical randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-02	Instituto de Cardiologia de Porto Alegre/Fundação Universitária de Cardiologia	Instituto de Cardiologia de Porto Alegre/Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-97bztb	<NULL>	Healthy volunteers enrolled in participating schools; both genders; aged 2 to 18 years;	Health problems that do not allow anthropometric evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-338wd8	Nonablative radiofrequency and phototherapy in facial wrinkles	Not yet recruiting	Intervention	2015-03-23	<NULL>	<NULL>	427	Effects of nonablative radiofrequency and phototherapy in reduction of periorbital and nasolabial wrinkles in young adult women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-23	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-338wd8	<NULL>	Healthy volunteers; female; aged between 30 and 50 years old; white to light brown skin phototype according to Fitzpatrick	Volunteers with skin sensitivity; who have performed facial cosmetic procedures or surgeries recently (for example: rhytidectomy and / or blepharoplasty, and chemical or physical ablative peeling in the last 12 months and who have made the past 6 months botulinum toxin or fills with collagen implants)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-3pyzt5	Efficacy and tolerability of Meclin® (meclizine hydrochloride) in Acute vertigo (a type of dizziness) and other types of dizzy spells identified by Otorhinolaryngologist	Not yet recruiting	Intervention	2015-03-10	<NULL>	<NULL>	428	Eficacy and tolerability of Meclin®(Meclizine Chlorhydrate) in acute vertigo	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-23	Universidade Federal de São Paulo - UNIFESP/EPM	Apsen Farmacêutica S/A	https://ensaiosclinicos.gov.br/rg/RBR-3pyzt5	<NULL>	Men and Woman aged above 18 years with presence of dizziness / vertigo of vestibular origin symptons , due to peripheral vestibular disorders, with dizziness / vertigo of vestibular origin symptoms, show  moderate intensity on in  5-points Likert  scale of: absent, mild , moderate , severe and very severe, if woman, negative Beta hcg and who present normal or controlled blood pressure;	Used meclizine or dimenidrynate in 15 days; Used alcohol in 48 hours; Pregnancy or breastfeeding; Presence of vomiting which prevent the ingestion of tablets; Presence of clinical condition that determines contraindication to the active substances : convulsions , suspected intracranial compressive processes , closed-angle glaucoma , prostatic adenoma with urinary disorders , liver diseases , endocrine , renal, and / or uncontrolled cardiovascular , Parkinson&apos;s disease; Participants with bladder neck obstruction or symptomatic prostatic hyperplasia : anticholinergic effects of Meclizine may precipitate urinary retention; a known sensitivity to hydrochloride, meclizine or dimenhydrinate; Presence of malignant carcinomas or not remitted for more than 5 years;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-5dq3cn	Kangaroo and behavior of the preterm infant	Recruitment completed	Observational	2015-03-27	<NULL>	<NULL>	429	Effects of Kangaroo Methods in the neurobehavior of preterm infants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-03-13	UNIVERSIDADE FEDERAL DE SÃO PAULO	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-5dq3cn	<NULL>	Preterm infants; gestational age between 28 and 32 weeks.	Congenital malformations; genetic syndromes; inborn errors of metabolism, symptomatic congenital infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2przxf	Evaluation of maternal supplementation with vitamin E in its natural form or synthetic on the levels of alpha-tocopherol in breast milk	Recruitment completed	Intervention	2015-03-27	<NULL>	<NULL>	430	Evaluation of maternal supplementation with vitamin E in its natural form (Acetate RRR-alpha-tocopherol) or synthetic (Acetate All-Race-Alpha Tocopherol) on the levels of alpha-tocopherol in breast milk	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2przxf	<NULL>	Lactating women; normal delivery; term delivery; aged 18 to 40 years.	Women with any clinical sign of disease; infections; syphilis; HIV; gastrointestinal diseases; liver disease; heart disease; diabetes; hypertension; cancer; twin pregnancie; newborn with fetal malformations; history of abortion; use of supplements containing vitamin E during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-7mcr59	The effect of music on the anxiety of children before surgery: a nursing intervention	Recruiting	Intervention	2015-03-31	<NULL>	<NULL>	431	The music listening applied to children undergoing surgery: a nursing intervention to relieve anxiety	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-22	Distrito Federal Secretaria de Saude	Distrito Federal Secretaria de Saude	https://ensaiosclinicos.gov.br/rg/RBR-7mcr59	<NULL>	children; age 3 to 12; both genders; to be subjected to any elective surgery; who agree to participate in the study, from the signing of free and informed consent term; that has a charge which agrees the child to participate in the research, from the signing of informed consent and informed	Children under 3 years of age and over 12 years; that will undergo emergency surgery; who have received premedication before the intervention to be tested; who have hearing problems and mental disorders; children or guardians who do not consent to take part or that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-82qrd2	Effect of overload and relief of air excess in the lungs on exercise capacity in people with Pulmonary Chronic Obstructive Lung Disease	Recruiting	Intervention	2015-03-31	<NULL>	<NULL>	432	Effects of pulmonary hyperinflation on the kinetics of oxygen uptake  in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-03	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-82qrd2	<NULL>	We will test 21 patients to reach a final eligible 7 patients with Chronic Obstructive Pulmonary Disease stage severe or very-severe and aged 40 to 75 years ; free of exacerbation for at least 2 months; on regular use of prescription drugs; should be able to perform spirometry and exercise testing; both gender; without important comorbidities like other chronic obstructive lung disease or cardiopathy; free of chronic domiciliar oxygen therapy	Patient with  ischemic heart disease ; recent myocardial infarction;  pulmonary arterial hypertension;  uncontrolled systemic hypertension;  diabetes mellitus or  anemia ; furthermore can not participate in the study patients with severe aortic stenosis or  musculoskeletal or rheumatic diseases and  inability to use cycle ergometer for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-3pxj3m	Respiratory Muscle Training in Patients with Chronic Kidney Disease Undergoing Hemodialysis Therapy	Recruitment completed	Intervention	2015-04-01	<NULL>	<NULL>	433	Inspiratory muscle training in patients with chronic kidney disease on hemodialysis.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-02	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-3pxj3m	<NULL>	Patients of both sexes, who undertake hemodialysis three times a week, for a minimum period of three months, which are not physically active, showing reduction in inspiratory muscle strength (PImáx &lt;70% predicted), and have signed the term of free and informed consent (TCLE).	Hemodynamic instability, amputation, deep vein thrombosis, severe dyspnea, femoral fistula, chest pain, unstable angina, active liver disease, orthopedic impairments, musculoskeletal, neurological and / or cognitive changes that compromise the participation in the proposed protocol, or even those individuals who refusing to sign the consent form free and enlightened (TCLE).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-93qtv5	Effects of aquatic exercises in trunk control and their interference in gait of subjects with cerebral palsy	Recruitment completed	Intervention	2015-04-06	<NULL>	<NULL>	434	Effects of aquatic exercises in trunk control and their interference in gait of subjects with cerebral palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-20	Hospital e Centro de Reabilitação da AACD	Hospital e Centro de Reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-93qtv5	<NULL>	Clinical diagnosis of spastic diparesis type of Cerebral Palsy; level II or III to the Gross Motor Function Classification System (GMFCS); aged 6 years to 15 years and 11 months.	Uncooperative patients; unable to understand the proposed activities; undergoing orthopedic surgery less than 12 months ago; undergoing peripheral blocks less than six months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-35xrwf	Change in the chest and blood pressure after exercise the muscle of respiration of patients with lung problem	Data analysis completed	Intervention	2015-04-06	<NULL>	<NULL>	435	Biomechanical and hemodynamic changes in patients with COPD treated with transcutaneous electrical stimulation diaphragmatic	<NULL>	0, single-arm-study, open	0	<NULL>	<NULL>	<NULL>	2010-07-31	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-35xrwf	<NULL>	Drug stability;smoking cessation; Classification COPD grade III  and IV; maintenance lifestyle; men and women; aged 18 to 80 years.	Metallic prosthesis; pacemaker; dermal injury.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-6w25zv	The Effectiveness of Acupuncture for patients with Tinnitus	Not yet recruiting	Intervention	2015-04-06	<NULL>	<NULL>	436	The Effectiveness of Acupuncture for patients with Tinnitus in relation to vitamin D and the amount of protein of IL6 and TNF Alpha activity: randomized crossover trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-11	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-6w25zv	<NULL>	Elderly individuals complaining of tinnitus of sensorineural origin; Men and women; Age 60 years or more.	Subjects presenting active cardiovascular disease;Cardiac pacemaker; Metallic prostheses or implants; Complaint of origin buzz for auditory; Working in a noisy environment or have a history of noise-induced hearing loss; Submit THI Questionnaire total score in less than thirty-six (36); Submit scores on the visual analog scale (VAS) less than five (5).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8ndqzk	The importance of information on quality of life of women with Polycystic Ovary Syndrome	Recruiting	Intervention	2015-04-07	<NULL>	<NULL>	437	Evaluation of the impact of access to information on quality of life of women with Polycystic Ovary Syndrome, a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-03	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8ndqzk	<NULL>	Being in the premenopausal period; between 15 and 50 years old; having the diagnosis of Polycistic Ovaries Syndrome by the Rotterdam criteria (2003); give written, informed consent to participate.	Previous psychiatric disorder; associated comorbidities that may affect the quality of life, such as diabetes, heart failure, collagen diseases, difficult to control hypertension, chronic kidney disease and obesity grade II or more;level below the 4th year of elementary school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-82gqqk	Platelet Rich Plasma infiltration for Hip Bursitis	Data analysis completed	Intervention	2015-04-07	<NULL>	<NULL>	438	Comparison of Platelet Rich Plasma (PRP) infiltration with Corticosteroid + Local anesthetic in patients with Hip tendinobursitis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2011-07-31	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-82gqqk	<NULL>	Twenty hips; both genders; aged eighteen to seventy nine years; more than three months of lateral hip pain; pain over the greater trochanter; painful with forced hip abduction; pain at rest; magnetic resonance imaging with diagnosis of tendinobursitis.	Previous hip infiltrations; intra articular hip disorders; spinal disorders; sciatic; neurological diseases associated with motor abnormalities; fibromyalgia; polyarthralgia or any other rheumatological diagnoses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4hvfzj	Physiotherapy techniques in Parkinson&apos;s Disease	Recruiting	Intervention	2015-04-07	<NULL>	<NULL>	439	Physiotherapy approaches in Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Sociedade Unificada de Ensino Augusto Motta - UNISUAM	Instituto de Neurologia Deolindo Couto (INDC) - Universidade Federal do Rio de Janeiro (UFRJ)	https://ensaiosclinicos.gov.br/rg/RBR-4hvfzj	<NULL>	Signed the Free and Informed Consent Statement; age of 50 to 80 years; both sexes; diagnosis of idiopathic Parkinson&apos;s disease (PD) according to the UK Parkinson&apos;s Disease Brain Bank; stage 1-3 on the Hoehn and Yahr disability scale; ability to ambulate alone for 10 meters; be using regular medication for PD; target sample of 60 participants.	Cognitive impairment (Mini-Mental less than or equal to 18); other neurological disorders; hypertension or uncontrolled arrhythmia; severe visual impairment uncorrected; vertigo; presence of metal implant brand or pacemaker; constant headache and without diagnosis; history of convulsion; use of medication that alters cortical excitability; younger than 50 years; older than 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8fdmb8	Effects of exercise in postmenopausal women	Data analysis completed	Intervention	2015-04-07	<NULL>	<NULL>	440	Impact of exercise on risk factors in overweight and obese postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-30	Universidade Estadual Paulista Júlio de Mesquita Filho de Presidente Prudente - SP	Universidade de Marília	https://ensaiosclinicos.gov.br/rg/RBR-8fdmb8	<NULL>	We included 70 women aged 50-79 years; postmenopausal (no period for at least twelve months); obese (fat percentage&gt; 33%); previously sedentary (&lt;150 minutes per week of moderate or vigorous physical activity in the past six months); all users of the Family Health Unit (USF); and no medical restrictions for physical exercise.	Introduced during the intervention health problems that limit or prevent the implementation of the exercise program; anyone associated with inflammatory responses such as influenza; diseases; recent surgical procedures; and acute arthritis condition; less than 65% frequency in the proposed interventions; not accomplish all assessment procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2cnzk7	Assessment the Effect of Combined Treatment of diuretic 1.5mg/angiotensin receptor antagonists 50mg and diuretic 1.5mg/angiotensin receptor antagonists 100mg, Compared With 1.5 mg diuretic Monotherapy in the Treatment of Hypertension	Not yet recruiting	Intervention	2015-04-07	<NULL>	<NULL>	441	"Randomized, phase III, multicenter, double-blind, double-dummy trial to assess the effect of combined treatment of Indapamide 1.5mg / Losartan 50 mg and 
Indapamide 1.5mg / Losartan 100mg, compared to monotherapy Indapamide 
1.5 mg in the treatment of essential hypertension"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-20	Hospital do Coração/Associação do Sanatorio Sírio	Dr. Celso Amodeo	https://ensaiosclinicos.gov.br/rg/RBR-2cnzk7	<NULL>	"Patients of both sexes, aged &lt;18 years; Patients with systemic hypertension (defined by medical researcher) alone (not by thiazide diuretic) and have at least two blood pressure measurements &lt;140/90, in sitting position, with 5 minutes interval; Patients with laboratory test results, in a period of up to 6 months before, within normal values ??(chemistry, hematology and urinalysis) or that the researcher considers them not clinically significant;
Patient who is willing to continue treatment for hypertension with medications the study. In this case, the patient will be randomized to drug or the combined use of thiazide diuretic, which would be internationally recommended drug for treating essential hypertension. If the patient is using other drug class, to include it in the study and perform the exchange of medication thiazide diuretic, it will be getting the best treatment available and recommended by national and international guidelines for its pathology."	Patients with blood pressure , 180/100 mmHg;Presence of concomitant coronary artery disease, congestive heart failure, diabetes and renal failure (creatinine&gt; 1.5 mg / dL);Patients with hypo or hyperkalemia (serum potassium outside normal range); Patients with alanine aminotransferase greater than 2.5 the upper limit of normal or active liver disease; Pregnant women, or women in childbearing age who are not in use effective contraception or intending to become pregnant during the study period; Patients on drug or alcohol abuse in the last two years; Patients with secondary hypertension (renovascular disease, pheochromocytoma, Cushing&apos;s syndrome); Patients with allergic reactions or hypersensitivity to ACE inhibitors, diuretics or medications containing sulfa and / or any excipients of formulation; Refusal or inability to provide the Informed Consent Term.; Refusal to discontinue the anti-hypertensive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-6hp2gq	Use of games in the treatment of postural deviations of schoolchildren aged 10 to 15 years	Not yet recruiting	Intervention	2015-04-10	<NULL>	<NULL>	442	Game therapy in the treatment of postural deviations of schoolchildren aged 10 to 15 years	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-05	Universidade Estadual do Centro-Oestre	Universidade Estadual do Centro-Oestre	https://ensaiosclinicos.gov.br/rg/RBR-6hp2gq	<NULL>	Children and adolescents with postural desviations; aged 10 and 15. The sample size will be 24 participants.	People with physical or mental disabilities; orthopedic injury , trauma or rheumatic ; having undergone surgery on the spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8tpphf	Effects of two physical exercise programs on the behavior of physical function and heart and analysis of inflammatory markers and respiratory gases in healthy subjects	Data analysis completed	Intervention	2015-04-13	<NULL>	<NULL>	443	Effects of two physical exercise programs on issues related to the physical, cardiovascular, biological and metabolic functions in healthy subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-8tpphf	<NULL>	Female subjects; apparently healthy; classified as inactive by the Baecke questionnaire for assessing habitual physical activity; age between 18 and 30 years.	"Being a smoker; making consumption of alcohol, 
drugs or medication; do not use contraceptives; have some disease; 
inflammatory process; presenting amenorrhea; 
episode of muscle-tendon injury or joint injury in the upper, lower limbs and / or column."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8dy6c3	Evaluation of methods of removing a complete denture adhesive	Recruitment completed	Intervention	2015-04-13	<NULL>	<NULL>	444	Effect of different Cleaning Methods on denture adhesive removal and influence in oral microbiota of denture wearers in vivo study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-10	Faculdade de Odontologia de Araraquara - UNESP	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-8dy6c3	<NULL>	Individuals with bimaxillary edentulous adults aged 40 to 80 years, of both sexes; users or non-conventional dentures; requiring preparation or replacement of dentures; receptive and mentally agile; ridges with normal resilience and volume	"Debilitating systemic diseases and pathological changes in the oral tissues such as neoplasms or candidiasis; neuromuscular impairment; D
diabetes mellitus; xerostomia; use of antibiotics in the period, or in the 3 months preceding the study; using denture adhesives"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4f6sh5	A study for evaluation of efficacy and safety of medicine for adult obesity treatment	Not yet recruiting	Intervention	2015-04-14	<NULL>	<NULL>	445	Prospective study, parallel, double-blind, multicenter, for evaluation of efficacy and safety of Orlistat 60mg for adult obesity treatment compared to Orlistat 120mg	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-01-15	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4f6sh5	<NULL>	Signed Informed Consent; Adults Male and Female over 18 years old; Obesity (body mass index equal or greater 25kg/m2);	Pregnancy and Lactation or women without effective contraception;Patients with Relevant chronic degenerative diseases;Obesity associated to genetic syndrome or other diseases;Patients with a history of hospitalization for decompensated diabetes in the last 6 months;Psychiatric disorders;Alcoholism: consumption of more than 3 doses of distillate, or any alcoholic drink daily; History of alimentary disorders, for example: bulimia; Use of anorectics, herbal and / or any drug (s) with or without approved indication for weight loss in the last 30 days; Use of drugs or laxatives for constipation in the last 30 days; Any history of Inflammatory Bowel Disease; History of acute diarrhea (viral or bacterial) in the last 30 days or chronic diarrhea; Patients using cyclosporine, amiodarone, dicumarinic; Prior bariatric surgery; History of anemia; Hemoglobinopathies and coagulopathy; History of cancer in the past five years; Use of corticosteroids, oral or injectable, in the last 30 days; People Related to investigators, family, employees of the sponsor or linked to the study center; Have participated in another study in the last two months; Patients who have no ability to observe / record the occurrence of gastrointestinal events.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6y4ghx	Biological and psychological correlates of mental illnesses	Recruiting	Intervention	2015-04-14	<NULL>	<NULL>	446	Biological and neurocognitive markers in neuropsychiatry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-23	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6y4ghx	<NULL>	Fifty patients with a diagnosis of obsessive-compulsive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); aged between 18 and 50 years; with at least primary school; able to use computers; under regular pharmacological treatment for at least 3 months.	Any condition that hinders the smooth progress of the procedure as psychiatric comorbidities that impedes the assessment with the dotprobe task or with symptom severity scales; cardiac pacemakers and some brands of cerebral aneurysm clips; cochlear implants and neurostimulators; firearm projectiles and other metal fragments depending on the location in the body.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5m6748	Use of galectin-3 as a blood marker for patients with Chagas disease.	Recruitment completed	Observational	2015-04-14	<NULL>	<NULL>	447	Validation of the use of galectin-3 as a biomarker for determining prognosis of patients with Chagas disease.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Hospital São Rafael	CBTC	https://ensaiosclinicos.gov.br/rg/RBR-5m6748	<NULL>	Chagas disease confirmed by 2 different serological tests; optimized drug therapy; NYHA functional class II-III-IV or patients with the indeterminate form; patients of any gender and aged 18 to 70 years.	Valvulopathy with hemodynamic consequences; chronic use of immunosuppressive agents; renal failure on current treatment by dialysis; acute infections or systemic infections in accordance with the definition of sepsis ACCP/SCCM (American College of Chest Phisicians/Society of Critical Care Medicine); abuse alcohol or illicit drugs (Based on DSM IV), any comorbidity with impact on survival in two years; liver, pulmonary, hematologic, neoplastic, bone, inflammatory or infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2md5dr	Use of microRNAs in patients with Chagas disease	Recruitment completed	Observational	2015-04-14	<NULL>	<NULL>	448	Determination of the prognostic value of the expression profile of micro RNAs in patients with Chagas disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Hospital São Rafael	Centro de Biotecnologia e Terapia Celular	https://ensaiosclinicos.gov.br/rg/RBR-2md5dr	<NULL>	Chagas disease confirmed by 2 different serological tests; optimized drug therapy; NYHA functional class II-III-IV or patients with the indeterminate form; patients of any gender and aged 18 to 70 years.	Valvulopathy with hemodynamic consequences; chronic use of immunosuppressive agents; renal failure on current treatment by dialysis; acute infections or systemic infections in accordance with the definition of sepsis ACCP/SCCM (American College of Chest Phisicians/Society of Critical Care Medicine); abuse alcohol or illicit drugs (Based on DSM IV), any comorbidity with impact on survival in two years; liver, pulmonary, hematologic, neoplastic, bone, inflammatory or infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-7p23c3	Effects of  Strength Training on women with Polycystic Ovary Syndrome	Recruitment completed	Intervention	2014-11-10	<NULL>	<NULL>	449	Effect of resistance physical training periodization  on women with Hyperandrogenic Anovulation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7p23c3	<NULL>	"Age between 18 to 37 years; 
Body Mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II);do not practice regular physical activity."	Presence of systemic disease that indicate against the practice of physical activity; presence of disabling musculoskeletal disorders; use of drugs that interfere with the hypothalamic-pituitary ovarian axis and hormonal contraceptives; smoking; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-9t48g5	Analysis of fatigue and immune response in patients with and without cancer treated with video game	Recruiting	Intervention	2015-04-16	<NULL>	<NULL>	450	Analysis of fatigue and immune response cells in cancer patients treated with exergames Randomized and controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Fisioterapia da Universidade Federal de Alfenas	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9t48g5	<NULL>	"Control group: Healthy individuals; both sexes; aged between 18 and 80 years.
Experimental group: individuals with cancer;  both sexes; aged between 18 and 80 years; chemotherapy; radiotherapy; after surgery with medical clearance for physical activity."	Cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergames.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-4twfv7	Influence of Bacterial Growing Properties in Treatment of Acute Exacerbation Chronic  Sinusitis	Recruitment completed	Intervention	2015-04-17	<NULL>	<NULL>	451	Influence of Bacterial Biofilms in Clinical Treatment of Patients with Acute Exacerbation Chronic  Rhinossinusitis	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2013-03-17	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4twfv7	<NULL>	Subjects of both genders, adults (older than 18 years) routine followed by outpatient management with clinical signs and symptoms compatible with acute exacerbation of chronic rhinosinusitis. Voluntarily agree to participate in the study and signed an informed consent and informed.	Patients who have used oral or topical antibiotics in the last 30 days; systemic corticosteroids in the past 30 days, who are using systemic antihistamine, systemic or topical decongestants. Patients younger than 18 years, pregnant women, patients with allergy to any component of amoxicillin-clavulanate or carrying any serious disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5stwwm	Effects of Tranexamic Acid on surgical tretament for severe nasal bleeding	Recruiting	Intervention	2015-04-17	<NULL>	<NULL>	452	Effects of intravenous Tranexamic Acid on surgical arterial ligations for severe epistaxis	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2013-10-01	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-5stwwm	<NULL>	Patients with severe spontaneous epistaxis; indication of surgical treatment; both genders; 18-90 years-old.	Formal contraindications to the use of tranexamic acid; acute vaso-occlusive disease; active intravascular coagulation; hypersensitivity to the components of the formula; known coagulopathy; use of oral anticoagulants; altered coagulation tests; use of the drug on the 7 days before inclusion in the study; patient&apos;s refusal to participate in the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-363zk7	Manipulation in the pelvis on ankle&apos;s instability	Recruitment completed	Intervention	2015-04-17	<NULL>	<NULL>	453	Effects of global manipulation in the pelvis on ankle&apos;s instability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-10	Universidade Estadual de Campinas	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-363zk7	<NULL>	Volunteer with ankle instability.	Who underwent surgery in the lower limb; with signs of inflammation in tested lower limb; who was treated with spinal manipulation in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-3st9f3	Osteopathic effects in patientes with heart disease	Recruiting	Intervention	2015-04-17	<NULL>	<NULL>	454	Effects of osteopathic manipulative treatment ( OMT )in  functionality of patients with congestive heart failure: a randomized clinical trial .	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	FCE - Faculdade de Ceilândia	FCE - Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-3st9f3	<NULL>	"For the experimental group : Congestive heart failure , cardiovascular disease, Chagas disease
For the control group : not having cardiovascular disease and be over 18 years."	"For the experimental group : New York Heart Association class I, hemodynamically decompensated patient , signs or symptoms of cardiovascular worsening in the last 3 months.
For the control group : cardiovascular disease , hypertension, surgeries , fibromioalgia , dysautonomia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6gs2jh	Evaluation of the Use of Antiseptic Nose For Decolonization of Resistant Bacteria in Hospitals	Recruiting	Intervention	2015-04-24	<NULL>	<NULL>	455	Evaluation of the efficacy of nasal application of silver sulfadiazine for decolonization of patients with methicillin-resistant Staphylococcus aureus in hospitals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gs2jh	<NULL>	Patients admitted in the Hospital das Clinicas, Ribeirão Preto Medical School, University of Sao Paulo; age over 18 years; isolation of methicillin-resistant Staphylococcus aureus.	Volunteers carry cystic fibrosis; patients with chronic osteomyelitis; carry infection related to foreign body; topic pregnancy with a live fetus; negative nasal swab for methicillin-resistant Staphylococcus aureus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-9gycqb	Evaluation of maternal supplementation with vitamin E and its influence on breast milk	Recruitment completed	Intervention	2015-04-25	<NULL>	<NULL>	456	Evaluation of maternal supplementation with vitamin E in its natural form (ethyl RRR-alpha-tocopherol) or synthetic (ethyl all-rac-alpha-tocopherol) on the levels of alpha-tocopherol in different stages of breast milk	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	https://ensaiosclinicos.gov.br/rg/RBR-9gycqb	<NULL>	Healthy lactating preterm births; single conceptus without malformation; aged 18-40 years; no history of abortion; without the use of vitamin supplements during pregnancy	Women with term delivery, ie, greater than 37 weeks gestation; that are experiencing conditions such as diseases of the gastrointestinal tract and liver, heart disease, infectious syphilis, HIV positive and neoplasia; multiple conceptus; who used vitamin supplements during pregnancy containing vitamin E.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-62qfc8	Octreoscan - kits production of tumor diagnosis neuroendocrine	Not yet recruiting	Intervention	2015-04-25	<NULL>	<NULL>	457	Octreoscan - kits production of tumor diagnosis neuroendocrine	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UBEA - União Brasileira de Assistência e Saúde	Grupo Radiopharmacus - RPH	https://ensaiosclinicos.gov.br/rg/RBR-62qfc8	<NULL>	Patients with histologically proven TNE; Which have been referred for the exam with 111In for staging disease and / or response to treatment; Any stage of the disease; 18 years old; Both sexes; Without receiving medication with somatostatin analogues for at least one month prior to taking pictures.	"Pregnant women;
Patients with previous resection of primary tumor without metastatic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-7c7ndt	Arthrotomy versus arthroscopy in the treatment of septic arthritis in adults knee joint: a randomized clinical trial with a 24-month follow-up	Data analysis completed	Intervention	2015-04-29	<NULL>	<NULL>	458	Open approach versus Arthroscopy surgery in the treatment of articular infection of the knee in adults: a randomized clinical trial with a 24-month follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Casa de Saúde Santa Marcelina	Casa de Saúde Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-7c7ndt	<NULL>	Knee septic arthritis confirmed by clinical and laboratorial exams, and age (patients aged 16 years or more were included). The clinical exam was considered positive for infection when there was pain, hyperemia, local warmth, joint swelling, or limited movement in walking. Synovial fluid collection by puncturing at admittance allowed diagnosis confirmation.	Patients with chronic septic arthritis, i.e., for more than 15 days, fractures, chronic wounds or ulcers in the knee, septic diseases affecting more than one joint, morbidities affecting the ability to walk or to move the knee. Allergic patients or those who could not receive the standard antibiotic therapy for any reason were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6pt2n3	Use of medications in preventing sensitivity arising from tooth bleaching.	Data analysis completed	Intervention	2015-04-29	<NULL>	<NULL>	459	Use of medications in preventing sensitivity arising from tooth bleaching.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-6pt2n3	<NULL>	Patients older than 18 years are included, with good oral and general health, with free maxillary anterior teeth restorations and do not carious lesion present, that have the color of A1 or darker teeth according to the color scale Classical Vita (Vita Zahnfabrik, Bad Säckingen, Germany).	"Patients who already underwent tooth whitening, pregnant or lactating patients, who report tooth sensitivity, severe browning (staining tetracycline, fluorosis or endodontics), with parafunctional habits, patients with dental prostheses and appliances Orthodontic and any other oral pathology will be deleted. Still be excluded patients who have systemic symptoms such as problems 
stomach, heart, kidney and liver, diabetes, hypertension or who are making continuous use of any medication with analgesic action 
and anti-inflammatory"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5qyjfr	Passion fruit effect on the central nervous system	Data analysis completed	Intervention	2015-05-05	<NULL>	<NULL>	460	Passion Fruit effect on the central nervous system	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2014-04-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5qyjfr	<NULL>	90 Individuals of both sexes; aged between 18 and 59 years; healthy self-appointed; residence in João Pessoa-PB, signing the free and informed consent term.	Subjects with any somatic or mental disorder diagnosed; pregnant women; individuals with chronic use of drugs, including drugs / substances that interfere in the degree of anxiety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-538g6x	The Pilates method increases respiratory muscle strength and perfomance and abdominal muscles thickness	Data analysis completed	Intervention	2015-05-05	<NULL>	<NULL>	461	Analysis of the thickness of the transversus abdominis muscle and respiratory muscle strength after application of the Pilates method	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-23	Centro Universitario Metodista, do Ipa	Prana Academia	https://ensaiosclinicos.gov.br/rg/RBR-538g6x	<NULL>	Woman physically inactive for at least six months without any experience in the Pilates method with no history of back pain or other condition which may influence abdominal muscle activity and signed an informed consent form	Pregnant women, smokers, obese, suffering from abdominal wall hernia, glaucoma, respiratory disease diagnosed, individuals who possess some skeletal muscle dysfunction and or respiratory diagnosed influencing the proposal from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6p8bhk	Exercises to improve posture in 10 to 13 year-old females	Data analysis completed	Intervention	2015-05-07	<NULL>	<NULL>	462	Relation between holistic gymnastics and posture in 10 to 13 year-old females	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-02	Universidade Estadual de CampinasUNICAMP	Universidade Estadual de CampinasUNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-6p8bhk	<NULL>	Age between 10-13 years; female gender; to sign the Informed Consent Form (ICF).	Sequel of orthopedic, rheumatic or neurological disease; Use of prosthetic limbs; pain during practice of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2hb4p8	Dynamic equilibrium of the lumbar and pelvis for the treatment of stress urinary incontinence in women	Recruitment completed	Intervention	2015-05-08	<NULL>	<NULL>	463	Dynamic stabilization lumbopelvic for treatment of urinary incontinence in womem	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Faculdade de Medicina - UFJF	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2hb4p8	<NULL>	literate women aged greater than or equal to 18 years with reports of efforts to urinary losses and sexually active	Possessing dystopias grades III and IV or use of anticholinergic drugs, pregnant women, women in treatment for urinary incontinence, pelvic diaphragm dysfunction or changes the alignment of the spine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2skhs4	Evaluation of improvement of fatigue in the legs and feet	Data analysis completed	Intervention	2015-05-08	<NULL>	<NULL>	464	Evaluation of clinical efficacy and perceived improvement of fatigue in the legs and feet	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2013-01-21	Medcin Instituto da Pele	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-2skhs4	<NULL>	"Pregnancy  between 12th and 30th week with a history of Chronic Venous Insufficiency with complaints of episodes of edema, fatigue and heaviness in the legs and feet; agreement to abide by the procedures of the trial and attend the clinic in the days and schedules 
determined for the application and readings and Signing the consent form"	Use of the following medications topical or systemic use: immunosuppressants, antihistamines, NSAIDs and corticosteroids within 30 days before the selection or considering immunosuppressants, the interval should be 3 months before screening; atopic or allergic to cosmetics history; active skin conditions in the assessment area; skin marks in the experimental area that interfere with evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, nevus aplenty, sunburn; pathologies that cause immune suppression, such as diabetes, HIV, endocrine diseases such as thyroid, ovarian or adrenal gland disorders; volunteers with known congenital or acquired immunodeficiency, relevant medical history or current evidence of alcohol or other drugs; known historical or suspected intolerance to products of the same category; intense sun exposure until 15 days before evaluation; aesthetic or dermatologic treatment in the assessment area up to 04 weeks before screening; professionals directly involved in the study design; other conditions considered by the evaluator as reasonable for medical disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5kd6sn	The clinical effect of physical therapy and osteopathy in chronic low back pain patients	Not yet recruiting	Intervention	2015-05-08	<NULL>	<NULL>	465	The clinical effectiveness of conventional therapy versus osteopathic manipulative treatment in patients with chronic nonspecific low back pain: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-5kd6sn	<NULL>	Pacients in the physiotherapy sector at the Gaffrée and Guinle University Hospital (HUGG); which have low back pain for more than three months; which have not undergone physiotherapy treatment in the last three months.	Patients who have a history of abdominal and lumbar surgery; infection; vertebral fracture; ankylosing spondylitis; cauda equine syndrome; cancer; radiculopathy in lumbar levels; lumbar stenosis; rheumatic syndromes and patients who receive some benefit labor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5jbxsf	Effects of protein supplementation in patients with low energy diet for the treatment of weight regain in the late postoperative surgical reduction of the stomach	Not yet recruiting	Intervention	2015-05-11	<NULL>	<NULL>	466	Efects of Metabolic and nutritional protein supplement diet in patients with low energy diet for treatment of weight regain in the late postoperative bariatric surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5jbxsf	<NULL>	60 patients 18-55 years old, female, undergoing surgery for gastric bypass with surgery in Roux-Y for more than 24 months and who had regained weight of at least 5% of the lowest weight achieved during treatment.	Patients with decompensated diabetes on hormone treatment, with renal or hepatic disease or using any medication for loss weight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5h6rzs	Effect of inspiratory muscle training on respiratory muscle	Recruiting	Intervention	2015-05-11	<NULL>	<NULL>	467	Effect of inspiratory muscle training on adaptation structural and neural of respiratory muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade Federal do Rio Grande do Norte	Rafaela Pedrosa	https://ensaiosclinicos.gov.br/rg/RBR-5h6rzs	<NULL>	Male and female; aged between 18 and 29 years; absence of visible deformities in the spine; absence of respiratory or neurological disease; absence of other significant pathology that could interfere in the recording of the electrical signal; BMI between 19 and 25 kg/m2; not show lesions at sites of electrode placement; FEV1/FVC&gt; 80% and FEV1&gt; 80% predicted; not being a smoker; not practice regular physical activity.	Inability to perform the protocol established by the study; present any problems during data collection; be unable to understand and/or perform procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-2gmhns	Constipation in students and its relationship to diet	Recruitment completed	Intervention	2015-05-11	<NULL>	<NULL>	468	Constipation in academics and its relationship with food consumption: prevalence and nutritional intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2gmhns	<NULL>	Constipation diagnosed from the Rome III Criteria	Under 18. Age of 60.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-32rfmb	The statin can prevent heart disease in renal transplant	Recruitment completed	Intervention	2015-05-13	<NULL>	<NULL>	469	The effects of statins on the progression of cardiovascular disease in kidney transplant patients	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-09-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-32rfmb	<NULL>	Kidney Transplant for within two months	Age below 18 years or above 60 years, creatinine clearance lower than 30 ml/min, patients prioritized for kidney transplantation and patients who had experienced any cardiovascular events 3 months prior to transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6wmjys	Body awareness therapy in women after breast cancer surgery	Recruiting	Intervention	2015-05-13	<NULL>	<NULL>	470	Effects of body awareness therapy in cardiac autonomic modulation of women after surgery for breast cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-20	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6wmjys	<NULL>	Women undergoing removal surgery for breast cancer; regardless of the type of procedure; mastectomy or quadrantectomy; with up to 1 year after surgery. For the control group healthy women; who didn&apos;t have cancer.Both groups aged between 40 and 60 years.	For women who have had breast cancer include non-medical consent, diagnosed metastasis; be in period of treatment with chemotherapy or radiation.For women in the control group the exclusion will be present another diagnosed pathology or any other type of cancer.Exclusion for both groups include arrhythmias; cardiac pacemaker or transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-7z358j	Effects of different oils consumption associated with diet on weight loss	Not yet recruiting	Intervention	2015-05-13	<NULL>	<NULL>	471	Effect of different fat sources consumption associated with low-calorie diet in controlling excess body weight	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Viçosa - UFV	Faculdade de Ciências Aplicadas da UNICAMP - Limeira	https://ensaiosclinicos.gov.br/rg/RBR-7z358j	<NULL>	women; with 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day	presence of chronic diseases; weight and physical activity instability; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-2q2vt5	Effects of inspiratory muscle training in patients with asthma	Recruiting	Intervention	2015-05-14	<NULL>	<NULL>	472	Effects of inspiratory muscle training in patients with asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Departamento de Fisioterapia	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2q2vt5	<NULL>	Asthmatic adults: confirmed diagnosis of asthma, based on the criteria of the Global Initiative for Asthma, 2012; controlled asthma; aged between 18 and 60 years; absence of prior lung disease cystic fibrosis kind, bronchiectasis, tuberculosis and pneumonia. Healthy adults: Age between 18 and 60 years; absence of prior asthma-like lung disease, cystic fibrosis, bronchiectasis, tuberculosis and pneumonia; pulmonary function and respiratory muscle strength of normal.	Appearance of some lung during the training period; inability to perform the protocol established; solicitaçãoo to exit the study;  accession training protocol smaller than 80%; overweight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-893zqw	Evaluation of improvement of fatigue in the legs and feet	Data analysis completed	Intervention	2015-05-14	<NULL>	<NULL>	473	Evaluation of clinical efficacy and Perceived Improvement of fatigue in the legs and feet	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-03	Medcin Instituto da Pele	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-893zqw	<NULL>	"Volunteer female; aged 35-65 years with a history of Chronic Venous Insufficiency; with complaints of episodes of edema, fatigue and heaviness in the legs and feet, agreement to abide by the procedures of the trial and attend the clinic in the days and schedules 
determined for the application and readings and Signing the consent form"	"Pregnant; lactating or planning to become pregnant during the study period; use of the following drugs of topical or systemic use immunosuppressants, antihistamines, NSAIDs, and corticosteroids within 30 days before the selection or considering 
immunosuppressants, the interval should be 3 months before screening; atopic or allergic to cosmetics history; pathologies and / or active skin lesions in the area of review (local and or / disseminated); skin marks in the experimental area that interfere with evaluation of possible skin reactions 
(vascular malformations, scars, increasing hairiness, nevus aplenty, sunburn); diseases which cause immune suppression, such as diabetes, HIV; 
endocrine disorders such as thyroid, ovarian or adrenal gland disorders; volunteers with congenital or acquired immunodeficiency known; relevant medical history or current evidence of alcohol or other drugs; 
History known or suspected intolerance to products of the same category; intense sun exposure up to 15 days before evaluation; or dermatological aesthetic treatment in the assessment area up to 04 weeks before screening; 
professionals directly involved in the study design; other conditions considered by the medical examiner as reasonable for disqualification from participation in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4d6wyn	Elastic bandages for pregnancy back pain	Recruiting	Intervention	2015-04-06	<NULL>	<NULL>	474	Kinesio taping for pregnancy lumbar pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-18	Faculdade Anhanguera de Campinas - unidade 3	Faculdade Anhanguera de Campinas - unidade 3	https://ensaiosclinicos.gov.br/rg/RBR-4d6wyn	<NULL>	Pregnant women with low back pain; between 20 and 30 gestational weeks; singleton pregnancy.	Pathology of the spine; urinary tract infection; pathology that limits daily activities; cognitive impairment; dermatitis or infection in the banding application site; known allergy to the material of the bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4v7j2d	Effect of maternal vitamin A supplementation on vitamins A and E in breast milk.	Recruiting	Intervention	2015-05-18	<NULL>	<NULL>	475	Assessment of maternal vitamin A supplementation on the retinol levels and alpha-tocopherol in human milk.	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	https://ensaiosclinicos.gov.br/rg/RBR-4v7j2d	<NULL>	Healthy volunteers; term delivery; conception without defect; aged 18-45 years; without a history of miscarriage; without the use of vitamin supplements during pregnancy containing vitamin A or E.	Premature birth; diagnosis of gastrointestinal, infectious, liver, heart, syphilis, HIV positive or neoplasms; conceptus multiple; with use of vitamin supplements during pregnancy containing vitamin A or E.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4wh4sh	Evaluation of dental restorations quality using a new universal adhesive, with different protocols	Recruitment completed	Intervention	2015-05-18	<NULL>	<NULL>	476	Clinical evaluation of a universal adhesive system with different etching procedures	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-22	Faculdade de Odontologia da Universidade Federal Fluminense	Faculdade de Odontologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-4wh4sh	<NULL>	Volunteers with a good general state of health; both gender; age between 18 and 70 years old; have an acceptable oral hygiene; have at least 20 teeth in occlusion; have at least four non-carious cervical lesions, which must have depth greater than 1mm, involve dentin and enamel in vital teeth without mobility, with cavo-surface angle involving no more than 50% of the enamel.	Volunteers with periodontal disease; with gingival bleeding; use of anti-inflamatory drugs in the last 30 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-69wpmz	Virtual reality exposure therapy as a means of health promotion in university: a randomized clinical trial	Recruitment completed	Intervention	2015-05-18	<NULL>	<NULL>	477	Virtual reality as a means of promoting health in university UFPR Setor Litoral	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Federal do Paraná - Setor de Ciências da Saúde/ SCS	Universidade Federal do Paraná - Setor de Ciências da Saúde/ SCS	https://ensaiosclinicos.gov.br/rg/RBR-69wpmz	<NULL>	Healthy students of the Federal University of Parana Coastal Sector; of both sexes; aged between 18 and 30 years.	comorbidities that interfered with evaluation of the participants as chronic, cardiovascular, musculoskeletal or neurological disease; students undergoing surgery last year; students that they had no time availability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-752vkn	Correlation existence between lumbar curvature, flexibility, low back pain and physical activity in Paraná Coast surfers	Recruitment completed	Observational	2015-05-18	<NULL>	<NULL>	478	Correlation between lumbar curvature, lumbar flexibility, low back pain and physical activity level surfers in the municipality of Matinhos-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-752vkn	<NULL>	Healthy volunteer; surfers for at least 6 months in the coast of Paraná; both genders; aged between 18 and 42 years.	Volunteers with sequelae of peripheral neurologic and vascular diseases; volunteers with a history of surgery for less than one year, disc herniation and / or fractures in the spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-7pbcdw	Low back pain during pregnancy: relationship between lumbar curvature, pain and stretching.	Recruitment completed	Observational	2015-05-18	<NULL>	<NULL>	479	Gestational low back pain: Correlation between the lumbar curve, lumbar flexibility and low back pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Paraná	Hospital Municipal de Matinhos	https://ensaiosclinicos.gov.br/rg/RBR-7pbcdw	<NULL>	pregnant women enrolled in Happy Mother Program of the Department of Pontal do Paraná Health and the Municipal Prenatal Program for Health Matinhos; aged between 18-40 years; with gestational age greater than or equal to 20 weeks.	Pregnant women diagnosed with high-risk pregnancy; twin pregnancy; presence of cognitive / mental disabilities; urinary tract infection; previous herniated disc; previous surgery in the spine, pelvis, hip or knee; presence of musculoskeletal or neurological dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4gj3hm	Infant development of children whose mothers with HIV	Recruiting	Observational	2015-05-18	<NULL>	<NULL>	480	Evaluation of infant development of children born soropositive mothers	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de São Paulo	KAITIANA MARTINS DA SILVA	https://ensaiosclinicos.gov.br/rg/RBR-4gj3hm	<NULL>	Children at ages 4,8,12 and 18 months of age whose mothers have HIV-positive diagnosis, inserted in a program of monitoring of children born to HIV positive mothers in a reference service (SENIC), absence of associated diseases and signing the Informed Consent Form (ICF) by parents or guardians. For the control group (CG), are born at term, matched in age, gender and socioeconomic status to (EG).	Children born to seropositive mothers presenting malformation, genetic syndromes, congenital abnormalities, postural deformities or other changes that may bring harm to the socio-cognitive and psychomotor development of children, or that parents do not sign the consent form, or even by any reason not to complete the assessment protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-58jw26	The efficacy of Distraction Technique to relieve pain in hospitalized children	Data analysis completed	Intervention	2015-05-18	<NULL>	<NULL>	481	The Distraction Technique in relieving pain and reducing stress in hospitalized children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-27	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58jw26	<NULL>	Children aged between six and 12; who had language skills to communicate; in hospital context with different diagnoses; requiring prescribed venipuncture or arterial puncture by clinical demand; with time minimum of one day of hospitalization and time interval of no more than seven days between the puncture procedures.	Children with neurological impairments; children with communication problems; children under sedation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-7d3kdn	Influence of prone posture and hand asleep and vital signs of infants born preterm	Recruitment completed	Intervention	2015-05-19	<NULL>	<NULL>	482	Comparison of physiological and behavioral parameters between preterm infants placed in the prone and lateral (crossover design)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-04	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7d3kdn	<NULL>	Were included in the study, premature babies, with post-conceptional age greater than or equal to 32 weeks and &lt;37 weeks and postnatal age&gt; 24 hours, of both sexes, in the case of twins, only one was chosen by lot.	Were excluded from the study, infants who present neurological impairment (hydrocephalus, microcephaly, periventricular hemorrhage grades III and IV and brachial plexus injury); who are making use of vasoactive drugs, central nervous system depressant that would influence or sleep; with congenital malformation (myelomeningocele, encephalocele, and agenesis focomielias); suspected of having some form of genetic alteration (no syndrome); changes with sensory (visual and auditory); with orthopedic disorders; with viral, bacterial or congenital infections (sepsis and meningitis); with herpes or syphilis; with Apgar scores of 4 or less in the 5th minute suggestive of suffocation; whose mothers abused intoxicants; sedated; coma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-5nw65z	Heart rate recovery after the exercise: influence of neural mechanisms	Recruiting	Intervention	2015-05-21	<NULL>	<NULL>	483	Heart rate recovery after exercise: regulatory mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5nw65z	<NULL>	Men. Aged between 40 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.	Subjects with obesity level 2 or greater(body mass index equal or greater than 35 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Use of anti-hypertensive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-556dhr	Colchicine to reduce arrhythmia in the postoperative period of cardiac surgery	Recruitment completed	Intervention	2015-05-22	<NULL>	<NULL>	484	Colchicine for reduction of Atrial Fibrillation after coronary artery bypass - randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-05-01	Hospital Santa Casa de Misericórdia de Curitiba	Hospital Santa Casa de Misericórdia de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-556dhr	<NULL>	Patients were recruited willing and able to provide informed consent and in accordance with the study procedures. All aged greater than or equal to 18 years; indication for elective coronary artery bypass grafting; sinus rhythm on the day preceding surgery. The mean age was 60.3 ± 8.1 years in the control group and 61.5 ± 10.3 years in the colchicine group (p = 0.44), 45 participants were female and 95 male. The sample size was 140 patients	Exclusion criteria were: contraindication for use of study medication; atrial fibrillation or atrial flutter previously diagnosed; need for associated valve surgery; severe liver disease (transaminases above 1.5 times normal); renal failure (creatinine&gt; 2 mg / dl); gastrointestinal diseases known; current treatment with colchicine; cardiogenic shock; severe arrhythmias; neoplasms; patients not communicative; Simultaneous use of antiarrhythmic drugs, excluding digoxin, beta-blockers and calcium channel blockers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-9mhs8r	Use of acupressure with breathing technique and relaxation for pain relief in labor	Recruitment completed	Intervention	2015-05-22	<NULL>	<NULL>	485	Acupressure associated with breathing technique and relaxation for pain relief during labor: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-09	Faculdade de Enfermagem da Universidade Estadual de Campinas	"Hospital da Mulher ""Profº Drº José Aristodemo Pinotti"" - CAISM - Universidade Estadual de Campinas"	https://ensaiosclinicos.gov.br/rg/RBR-9mhs8r	<NULL>	156 women in labor; 37 weeks gestation or more; single and cephalic fetus; cervical dilation greater than or equal to 4 cm; two or more contractions in 10 minutes; skin integrates on acupressure point.	Pregnant women with severe hypertensive disease; pregnancy bleeding; early indication of cesarean section; dilated cervix equal to or greater at 8 cm; analgesic drug use for less than 6 hours of admission in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6673s5	Population survey on the prevalence of cardiovascular disease - multidisciplinary intervention in adults with  hypertension	Data analysis completed	Intervention	2015-05-25	<NULL>	<NULL>	486	Population survey on the prevalence of risk and protective factors for cardiovascular disease in the metropolitan region of Maringá	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-16	Universidade Estadual de Maringá	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-6673s5	<NULL>	Medical certificate of fitness to practice physical exercises; interest and willingness to regularly attend the activities of the intervention; accepting perform all physical and biochemical evaluations on two occasions (before and after the start of the activities of the GI)	Presenting disability to carry the exercise; do not accept accomplish all assessment proposals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-5jjzhy	Immersion in cold water effects in the physical reestablishment after exercise	Recruitment completed	Intervention	2015-05-25	<NULL>	<NULL>	487	Immediate and late effects of immersion in cold water in the post-exercise recovery on clinical, functional, metabolic, autonomic and cardiovascular parameters	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-5jjzhy	<NULL>	Healthy volunteers; male; aged 13 to 18 years; football players.	Smokers volunteers; use of medications that affect autonomic activity of the heart as, for example, beta blockers and angiotensin converting enzyme inhibitors; alcoholics; Use of chronically inflammatory drugs such as, for example, betamethasone; Diagnosis of metabolic disorders and / or endocrine known, for example, diabetes mellitus and dislipedemia; and are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-85gzsj	Effect of Music on Weight Gain of Premature Infants	Data analysis completed	Intervention	2015-05-26	<NULL>	<NULL>	488	The effect of Music on weight gain of Premature hospitalized infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-26	Universidade Federal de São Paulo	Maternidade Escola Santa Mônica	https://ensaiosclinicos.gov.br/rg/RBR-85gzsj	<NULL>	"Preterm infants with post-conceptional age greater than or equal to 32 weeks.
Normal hearing by evoked otoacoustic emissions bilaterally.
Normal vision by visual assessment and examination of the fundus bilaterally"	"Presence of severe hypoxia, intracranial hemorrhage, pulmonary,cardiac, and neurological problems, malformations and syndromes
Presence of clinical complications during the study period, as signs of respiratory distress, diarrhea or reflux"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-3p2vc2	Diet and risk of chronic diseases among college students	Recruitment completed	Intervention	2015-05-28	<NULL>	<NULL>	489	Food consumption as a risk factor for chronic diseases among university students: prevalence and nutritional intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3p2vc2	<NULL>	Inadequacies in food consumption	Not have completed a total of 3 units of food records before the start of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-7yx9hd	Evaluation of brief intervention for smoking: pilot study of a randomized clinical trial	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	490	Cost-effectiveness evaluation between two approaches to treatment of smoking in the SUS (Unified Health System): brief intervention and intensive approach to the smoker	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-24	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7yx9hd	<NULL>	Daily use of cigarettes for at least one year; Be at least 18 years old; Provide permanent address and phone for contact; Agree to be allocated to one of the groups and to participate in the three- and six-month follow-ups;sample size target 80 people.	Failure to understand the instruments used; Presenting Psychotic Syndrome, Mood disorder with psychotic features; Manic or hypomanic episode; suicide risk (moderate or severe), and dependence on alcohol or other drugs (besides nicotine).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4j35g5	Evaluation and treatment of changes due of pregnancy and postpartum	Recruiting	Intervention	2015-06-01	<NULL>	<NULL>	491	Evaluation and treatment of changes in gait, postural balance, strength of pelvic floor, sexual function, sleep and quality of life in cycle puerperal pregnancy:randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4j35g5	<NULL>	Does not provide obstetric and clinical  changes;  age between 18 and 37 years;  are in the second ( 16th to 20th weeks) or third (28th to 32th weeks) trimesters of pregnancy; confirmed by ultrasonography; were nulliparous;  single-fetus pregnancy;  no physical activity during the survey period; no history of depression or anxiety;  do not use drugs / substances that affect balance or sleep;  report changes in the quantity or quality of sleep;  no history of balance disorders and sleep before pregnancy;  has identified changes in postural balance through the Balance Master®;  absence of previous surgery in spine, pelvis, hip and knee;  no history of epilepsy and photosensitivity;  absence of musculoskeletal, cardiopulmonary and neurological disorders that prevent the completion of the evaluation and treatment protocols; no modifications of the pelvic floor muscles before pregnancy ;  no changes in sexual function before pregnancy; having a steady partner for at least six months	"to present clinical and obstetric change; be  under 18 and more than 37 years; be in the 1st trimester; be multiparous; twin pregnancy; physical activity during the study period; present history of depression or anxiety; make use of drugs / substances that affect balance or sleep; not report changes in the quantity or quality of sleep; report history of balance and sleep disorders before pregnancy; without alterations postural balance identified through the Balance Master®; report previous surgery on spine, pelvis, hip and knee; report history of epilepsy and photosensitivity, musculoskeletal, cardiorespiratory and neurological disorders that impede the completion of the evaluation and treatment protocols; report changes of the pelvic floor muscles before pregnancy; show changes in sexual function before pregnancy; not have a steady partner for at least six months
Criteria for removal of study: Miss three consecutive meetings or not the Preparatory Course for Pregnancy, Childbirth and Postpartum or the intervention sessions; complaining against any nuisance arising from stimuli demonstrably offered during the exercises; refused to complete the questionnaires and present obstetric complications during the period of the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8whr7r	Effects of diagnostic errors on variability of assessment and intervention with acupuncture	Recruitment completed	Observational	2015-06-01	<NULL>	<NULL>	492	Effects of diagnostic errors on Interrater Reliability for Pattern differentiation and Acupoints prescription	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-11-27	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8whr7r	<NULL>	Adults; either gender; bachelor degree in any health-related course recognized by the National Ministry of Education, including biomedicine, nursing, physical therapy, speech therapy, physician, nutrition, dentistry, psychology, and occupational therapy; postgraduate training in acupuncture; signature of the informed consent form after reading about the objectives, potential risks and benefits for participating in this research.	Professionals with postgraduate training not registered at the respective professional council; clinical practice less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6fpss8	The effect of teaching foot care for people with Diabetes Mellitus type II	Recruitment completed	Intervention	2015-06-01	<NULL>	<NULL>	493	The effect of teaching foot care to prevent risk of impaired skin integrity of the feet of people with Diabetes Mellitus type II	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-04	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6fpss8	<NULL>	"The target sample size is 72 people with Diabetes Mellitus type II diagnosed for at least five years;
registered in the System of Registration and Monitoring Hypertensive and diabetic-Hiperdia; with a minimum age of eighteen years and maximum age not stipulated and both genders."	Presence of foot ulcers; presence of amputations of the lower limbs; presence of thrombosis; deficit in cognitive ability, defined by the Mini Mental State Examination (MMSE)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-7drnzt	Diminution of fasting in cirurgia using carbohydrate.	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	494	Comparison of parameters of respiratory strength in postoperative elective cholecystectomy by laparotomy when respected conventional fasting and 2 hours fasting.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal do Mato Grosso - UFMT	CAPES- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7drnzt	<NULL>	Patients with an indication for cholecystectomy by laparotomy and rachianesthesia; aged 18 to 60 years; with body mass index (BMI) ranging from 18.5 to 29.5 kg/m²; ASA I and II and Subjective Global Assessment (SGA) A.	Requiring  cholecystectomy with bile duct exploration; patients who underwent surgery with operative time greater than 120 minutes or whose anesthesia had to be converted to general anesthesia; needing immediate surgical reintervention; patients with complications in the postoperative period; pregnant patients and those with diabetes; hypertension; lung disease; heart disease; arthritis and gastroesophageal reflux disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6sckn6	Simplified technique for dentures: the influence of denture quality, chewing ability and patient satisfaction	Recruiting	Intervention	2015-06-01	<NULL>	<NULL>	495	Simplified technique for complete dentures: influence on             quality prostheses, masticatory function and patient satisfaction.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Faculdade de Odontologia de Piracicaba Universidade de Campinas	Secretaria municipal de saúde de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-6sckn6	<NULL>	60 volunteers will be selected edentulous. Both genders. Aged between 40 and 90 years. The Volunteers should be in good general health.	Volunteers sign or symptom of dysfunction temporomandibular.Que lost teeth for less than a year. Who do not have cognitive ability. That are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8g9dbc	Association of the elastic bandage to Manual Therapy in the neck pain	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	496	Association of the Kinesio Taping to Manual Therapy in the neck pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Faculdade Integral Diferencial	Multifisio Clínica de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8g9dbc	<NULL>	Target sample of 10 volunteers of both genders who sought physiotherapy service complaining of neck pain and age between 21 and 30 years	Historic injury in cervical whiplash; diagnosis of pathologies associated like neoplasia and thrombosis; presence of open wounds; allergies to bandage; use of drugs a week before the study or during its accomplishment and that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4c3dzq	Respiratory Training effects in patients on hemodialysis	Recruitment completed	Intervention	2015-06-02	<NULL>	<NULL>	497	Effects of inspiratory muscle endurance training in patients undergoing hemodialysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-15	Universidade de Passo Fundo	Hospital São Vicente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c3dzq	<NULL>	Both sexes; above 18 years; conducting hemodialysis three times per week; minimum period of three months; not-exercising; showing reduction in inspiratory muscle strength MIP &lt;70% of predicted	Hemodynamic instability; deep vein thrombosis; Use of the catheter; severe dyspnea; chest pain; unstable angina; active liver disease; orthopedic, neurological, musculoskeletal, neurological and / or cognitive changes that compromise the interests in the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-5qhmb5	Interpersonal psychotherapy counseling for depressed children’s caregivers	Recruitment completed	Intervention	2015-06-02	<NULL>	<NULL>	498	Interpersonal psychotherapy counseling for Depressed children’s caregivers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-10	Universidade Federal de São Paulo	Columbia Univertisy	https://ensaiosclinicos.gov.br/rg/RBR-5qhmb5	<NULL>	Depressive episode due to the presence of TDM according to the criteria of the DSMIVR received after administration of KSADS; score lower than 20 on the HDRS; both sex; be under 12 years old; parents must consent to participation by signing the informed consent form previously approved by the Ethics Committee of UNIFESP; preferably one caregiver to the child&apos;s mother with depressive episode due to TDM according to the DSMIVR criteria received after the SCIDI administration consent to the participation in the clinical trial.	Caregiver who receive treatment are using antidepressant medications or psychotherapy is in process; have a risk of suicide assessed by an item of PHQ9 scale, or have a score lower than 3 on the HAMD3, or through the clinical judgment of the SCID applicator; presents diagnostic criteria after administration of the SCIDI for psychoactive substances in the past 6 months; presents diagnostic criteria for bipolar disorder, schizophrenia or related disorders by administering the SCIDI; assumes that do not have the opportunity to follow the TIP sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-7xc5kj	How to make women with fibromyalgia become interested in physical exercises daily?	Recruitment completed	Intervention	2015-06-02	<NULL>	<NULL>	499	How to motivate women with fibromyalgia to join the exercise continued?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-21	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7xc5kj	<NULL>	Women from 18 years diagnosed with fibromyalgia performed by rheumatologists; according to the American College of Rheumatology (ACR 1990). The estimated sample size was 30 volunteers.	Women who have comorbidities which is a contraindication to physical activity; recent change of medication (in the last two weeks); and / or already do moderate-intensity physical activities regularly (more than 30 minutes up to three times per week)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4psjwb	Self-care program  focusing on the assistive devices effects for individuals with hand osteoatrhritis	Recruiting	Intervention	2015-06-05	<NULL>	<NULL>	500	Self-care program focusing on the Assistive Technology effects for patients with the hand OA	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4psjwb	<NULL>	The sample consists of 40 volunteers with the following inclusion criteria: Hand OA diagnostics (ACR); Be registered at the Hospital das Clinicas, Federal University of Pernambuco; minimum age 18 and maximum age of 90 years.	Surgical treatment or infiltration in the hands in the last 6 months;Treatment of occupational therapy and / or physical therapy or use of any TA feature (assist device or split) in the last 6 months; Diagnosis of another rheumatologic disease or musculoskeletal disease that compromise the hands.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6ffm72	Effects of exercise on nerve action that controls the muscle fibers and blood vessels of patients with pre-dialysis chronic kidney disease	Data analysis completed	Intervention	2015-06-05	<NULL>	<NULL>	501	Effect of aerobic exercise on muscle sympathetic nerve activity in predialysis chronic renal	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ffm72	<NULL>	21 Men and women; between 30 and 60 years; Without participation in structured physical activity; not obese; nondiabetic. They were divided into 2 groups: Control (normotensive patients) and Chronic renal disease, stage III (creatinine clearance 30 to 60 mL / min / 1.73m2, hypertensive controlled in use of angiotensin converting enzyme inhibitors or  Angiotensin receptor antagonists).	Patients with anemia; in the chronic kidney disease group, we excluded patients who were taking beta-blockers and sympatholytic. And also with creatinine clearance &lt;30 and&gt; 60 mL / min / 1.73m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-2q52rs	Effects of health education in the prevention of cervical cancer	Recruitment completed	Intervention	2015-06-05	<NULL>	<NULL>	502	Impact on education intervention in the adherence to the cervical cancer prevention	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-09-22	Universidade Federal do Triângulo Mineiro (UFTM)	Universidade Federal do Triângulo Mineiro (UFTM)	https://ensaiosclinicos.gov.br/rg/RBR-2q52rs	<NULL>	180 women; aged between 25 and 64 years; public service users of municipal health to perform Pap	Women who are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-92j38t	The educational program evaluation in diabetes mellitus	Recruitment completed	Intervention	2015-06-05	<NULL>	<NULL>	503	The educational program on diabetes mellitus reviewed focus on empowerment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-16	Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-92j38t	<NULL>	Belonging to the health strategy of the urban family; aged between 30 and 80 years; diagnosis of type 2 diabetes; schooling for responding to the questionnaires; availability to attend the education program. Sample size target: 304 people.	Reading disability; have at least one chronic complication of diabetes mellitus and renal failure; retinopathy; amputation of limbs or diabetic foot.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-47hhbj	Effects of Auriculotheray in women during labor	Recruiting	Intervention	2015-06-07	<NULL>	<NULL>	504	Effects of Auriculotheray in women during labor: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM/UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-47hhbj	<NULL>	99 women in labor; 37 weeks gestation or more; single and cephalic fetus; cervical dilation greater than or equal to 4 cm; two or more contractions in 10 minutes; skin integrates the ear.	Pregnant women with severe hypertensive disease; pregnancy bleeding; previous cesarean section; dilated cervix equal to or greater at 7 cm; analgesic drug use for less than 6 hours of admission in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-3b3m2r	Effects of Physical Therapy on  Temporomandibular Disorder in Patients with Fibromyalgia	Recruitment completed	Intervention	2015-06-07	<NULL>	<NULL>	505	Effects of Physical Therapy on Myogenous Temporomandibular Disorder in Patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-13	Universidade Federal de São Paulo / Hospital São Paulo	Universidade Federal de São Paulo / Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3b3m2r	<NULL>	Fourteen women between 30 and 60 years old; diagnosed with fibromyalgia; presented pain in the jaw, temples, face, preauricular area and ears at rest or during function  and palpation of three or more of the 20 muscle sites (tendon and temporalis, masseter, submandibular region, the lateral pterygoid area) muscle;   limited mouth opening; visual analogue scale (VAS) between 3 and 7.	internal derangement of the temporomandibular joint, a predominantly mouth breathing pattern, systemic, pulmonary or cardiac musculoskeletal disease and history of trauma to the face or cervical spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6hjt5q	Effectiveness of using teleconsultation in discharge in referral hospital for patients with stable coronary disease	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	506	Evaluation of the effectiveness of the use of teleconsultation in qualifying the counter-referral between primary and tertiary care to patients with stable coronary artery disease: a randomized non-inferiority trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-08	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6hjt5q	<NULL>	Chronic stable coronary artery disease over a year; functional class I or II at the time of consultation; do not have hospitalization in the last year from cardiovascular disease	Unstable patients who require medication adjustments; Patients who are performing some diagnostic evaluation at query time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-9ygmdn	Effect of different kinds of physical training (aerobic, resistance and concurrent) on vascular function and blood pressure in hypertensive individuals	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	507	Physical Training Effect on Endothelial Function and Blood Pressure in Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-04	Instituto de Cardiologia - Fundação Universitária de Cardiologia/ ICFUC	Coordenação de Aperfeiçoamento de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9ygmdn	<NULL>	Patients aged between 18 and 75 years; diagnosed with hypertension; not participate in any kind of systematic physical activity; be ranked among insufficiently active, as IPAQ; signing the consent form; not present hyperreactivity during the test the physical tests (SBP&gt; 220 mmHg and / or increase of more than 15 mmHg for DBP); not febrile and / or infectious disease state, as well as diabetes mellitus; not class II obesity or more 35 kg / m2; not present heart failure class III or IV; recent cardiovascular event in the last three months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; not be active smoker and not present alcoholism; not have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises.	Patients outside the age range of 18 to 75 years; without diagnosis of hypertension; be participating in some kind of systematic physical activity; not sign the Instrument of Consent; hyperreactivity present during the test the physical tests, presenting fever and / or infectious disease as well as diabetes mellitus; class II obesity or having more than 35 kg / m2; present heart failure class III or IV; cardiovascular event in the last 3 months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; be active smoker and present alcoholism, have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises; will still be excluded from the sample individuals who have not obtained attendance to 85% of the number of training or miss more than two consecutive workouts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-34677v	Use of videogames as physical training for children and adolescents with cystic fibrosis during hospitalization	Not yet recruiting	Intervention	2015-06-09	<NULL>	<NULL>	508	Use of interactive games as aerobic training for children and adolescents with Cystic Fibrosis during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34677v	<NULL>	17 individuals diagnosed with cystic fibrosis; both sgenders; aged from six years; hospitalized at São Lucas Hospital (PUCRS).	Children and adolescents with arm/leg problems that could interfere in the exercise performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4phm6k	Eficacy and safety study of drug that contains Pycnogenol which is used to treat spot on the skin	Not yet recruiting	Intervention	2015-06-09	<NULL>	<NULL>	509	Randomized, double-blind clinical study in order to assess the tolerability and dermatological efficacy of a drug that contains Pycnogenol, which is used to treat Melasma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-10-01	Medcin Instituto da Pele	Farmoquimica	https://ensaiosclinicos.gov.br/rg/RBR-4phm6k	<NULL>	"100 participants; age range 25-65 years old; female; fitzpatrick skin types II and III;
patients with facial melasma; without any other cutaneous disease; without previous reaction to topical product; the patient should agree with the study-related procedures and the determinated days and time of  appointments; Reading; understanding; agreement and signature of patient on the written informed free consent form."	Pregnancy; lactation; hormonal therapy within the last 4 weeks; use of photosensitizing  drug; any melasma treatment in the same time;intensive solar exposure within the last 15 days and during the study; cutaneous marks on the experimental area that might  interfere with cutaneous reaction evaluation; use of corticoide until 30 days before the selection and during the study;endocrine dysfunction; use of cosmetic products that might cause any facial irritation , even if it is mild such as exfoliating and antiaging products; other conditions that may  be considered by doctors as a reason for disqualification of patient’s participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4cmwkm	Caries preventive effective in relation to different types of sealants	Recruitment completed	Intervention	2015-06-09	<NULL>	<NULL>	510	Effectiveness of two sealant materials in preventing carious lesions in newly erupted first permanent molars.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Universidade de Brasília	Renata Nunes Cabral	https://ensaiosclinicos.gov.br/rg/RBR-4cmwkm	<NULL>	5 to 7 years old children (n = 56) from a public school were orally examined and those that were classified as medium or high risk to dental caries and presenting newly erupted 1st molars without cavitated lesions were invited to participate	Parents that did not sign the informed consent and those children that did not allow the dental examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-4rnq3v	Effects of a workout program in patients with HIV and cocktail use for over than one  year and treated at a university hospital: a randomized clinical trial	Recruiting	Intervention	2015-06-09	<NULL>	<NULL>	511	Effects of a program of periodized resistance exercise in patients with HIV in HAART therapy more than one year and served in a university hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4rnq3v	<NULL>	"Be patient infected with HIV and use of antiretrovital therapy for over one year seen at the Infectious and Parasitic Diseases sector of a university hospital. Be older than 18 and less than 60. Having health conditions for the practice of the proposed exercise. Being sedentary. Having availability displacement three times per week for the training local.
Target sample: 34 patient."	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-26ssvc	Temperature and humidity of the gases in a workstation anesthesia machine	Recruitment completed	Intervention	2015-06-11	<NULL>	<NULL>	512	The temperature and humidity of the inhaled gas in an anesthesia workstation  using a low fresh gas flow  with or without thermal insulation or heat and moisture exchanger	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-30	Universidade Estadual Paulista	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-26ssvc	<NULL>	Female gender volunteers; American Society of Anesthesiologists physical status 1 or 2 (healthy or with a controlled disease); body mass index (relation between the weight and the height) between 20 and 30 kg/cm²; scheduled for elective open abdominal gynecologic surgery.	Volunteers with fever; decompensated endocrinologic disease; using drugs that interfere with arterial blood pressure or heart function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-65g6xz	Postoperative physiotherapy in kidney transplantation.	Recruitment completed	Intervention	2012-01-04	<NULL>	<NULL>	513	The impact of physiotherapy on exercise tolerance, muscle strength, pulmonary function and quality of life in kidney transplant patients six months after surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de São Paulo - UNIFESP	Universidade Cidade de São Paulo - UNICID	https://ensaiosclinicos.gov.br/rg/RBR-65g6xz	<NULL>	Patients undergoing living donor kidney transplant; Any sex; Age 18 to 60 years.	Age 18 to 60 years; Any sex; Time of invasive mechanical ventilation longer than 24 hours post-transplant; Stay in the intensive care unit, ICU, for a period longer than 48 hours; Cognitive interfering in the techniques to be instituted; Pulmonary and cardiovascular complications in 24 hours after renal transplantation, such as pneumonia, pneumothorax, myocardial infarction, unstable angina, deep vein thrombosis and / or pulmonary embolism; Patients who underwent surgical intervention; Patients who present contraindications for testing the six-minute walk: orthopedic impairments, unstable angina and acute myocardial infarction in the last month, heart rate (HR) greater than 120 bpm at rest, systolic blood pressure greater than 180 mmHg or diastolic greater than 100 mmHg; Intraoperative death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8jg3bk	Electric current therapy for patients with pain caused by circulatory problems in the legs and feet	Recruiting	Intervention	2015-06-11	<NULL>	<NULL>	514	Transcutaneous electrical nerve stimulation in patients with pain caused by chronic lower limb ischemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-26	Universidade Federal  de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-8jg3bk	<NULL>	72 hospitalized patients; diagnosed with critical ischemia of the lower limbs; of both genders; aged over 18; with ischemic rest pain in the lower limbs; who are waiting for vascular surgery.	Patients with contraindication for application of electrotherapy; patients who have already undergone therapy with transelectrical nerve stimulation prior to the trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-5yr2yx	Alterations in gastric mucosa of cirrhotic patients	Data analysis completed	Observational	2015-06-11	<NULL>	<NULL>	515	The effect of portal hypertension on elevated gastric antrum erosions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo - FCMSCSP	Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5yr2yx	<NULL>	The study included 69 volunteers of both sexes; from 18 to 80 years of age; presenting elevated antral erosions during endoscopy; with or without portal hypertension.	The volunteers who had prior treatment to eradicate Helicobacter pylori; who had recently used antibiotics or who have not agreed to participate in the study were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8fz3mj	Study of the profile and the effects of an exercises program in patients candidates for liver surgery and liver transplantation	Data analysis completed	Intervention	2015-06-12	<NULL>	<NULL>	516	Study of the profile and the effects of an intervention program in patients candidates for liver surgery and liver transplantation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-10	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8fz3mj	<NULL>	We included 37 patients who were on the waiting list for liver transplantation diagnosed with cirrhosis of any etiology; of both genders; over the age of 18; with or without the diagnosis of cardiorespiratory disorders associated with any value and MELD. These patients participated in the intervention group.	Patients who were unable to understand verbal commands due to the important encephalopathy were excluded; who failed to carry out evaluations; diagnosed with severe acute liver failure and those who were called to transplantation or patients participating in the intervention group who died.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-36scyk	Impact of monitoring in the breastfeeding by health professionals	Recruitment completed	Intervention	2015-06-15	<NULL>	<NULL>	517	Impact of monitoring by health professionals in the practice of breastfeeding. A randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-16	Faculdade de Odontologia de Araçatuba - UNESP	Faculdade de Odontologia de Araçatuba - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-36scyk	<NULL>	Pregnant women who are in the last two months of pregnancy, ie after 32 weeks; pregnant women aged 14 to 50 years and pregnant women who consent to participate.	Mothers or babies with some sort of disease that prevents the practice of breastfeeding (HIV, birth defects, etc.), non-pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-5ns6sg	Effects of Exercise and Diet on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality in Hemodialysis patients	Recruiting	Intervention	2015-06-21	<NULL>	<NULL>	518	Effects of Exercise and Nutritional Intervention on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality  in hemodialysis patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5ns6sg	<NULL>	155 patients of both sexes; aged 20 and 79; for at least three months in haemodialysis treatment; sedentary; kidney therapy performed through access fistula; and adequacy of treatment of haemodialysis (Kt/V&gt;1.2.	patients with disability and severe orthopedic impairments; acute myocardial infarction history in the last six months; recent hospitalization (&lt;3 months; decompensated diabetes; consuming vitamin supplement; which have thyroid dysfunction; and patients who have food intolerance baru.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-72kkgc	Use of surfactant with corticosteroids to prevent chronic lung disease in premature infants	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	519	Intratracheal instillation of budesonide, using surfactant as a vehicle, in the prophylaxis and rescue therapy of neonatal respiratory distress syndrome to prevent bronchopulmonary dysplasia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-13	Hospital das Clínicas da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-72kkgc	<NULL>	Every newborn with 0-2 hours of life; both sexes; who required prophylactic surfactant or early redemption replacement therapy. Sample size target: 90 research subjects.	"Loss of follow-up of the newborn before 28 days of chronological age (except in case of death);
Congenital malformations of heart and lung; except patent ductus arteriosus and pervious foramen ovale."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-2jgrkq	Use of Postoperative Intravenous Iron in Abdominoplasty After Bariatric Surgery	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	520	Use of Postoperative Intravenous Iron in Abdominoplasty After Bariatric Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jgrkq	<NULL>	Sample size: 56 patients, Women; 18 to 55 years old; previous bariatric surgery; BMI less than 32 kg/m2; Stability of weight loss for at least 6 months	smoking; cholelithiasis demonstrated on ultrasound; uncontrolled systemic diseases; bone marrow diseases; hematological disorders; presence of renal or hepatic insufficiency; acute infection; prior use in the last three months of intravenous iron; hemoglobin level less than 11.5 g/dL; ferritin level less than 11 ng/mL or greater than 100 ng/mL; transferrin saturation index below 20% or exceeding 50%; a level of less than 210 pg/mL vitamin B12; folic acid level of less than 3,3 ng/ml, albumin level less than 3 g/dL; C-reactive protein greater than 5mg/L; mean corpuscular volume less than 80 fL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6cf6rp	Effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	521	Prospective, double-blind, randomized, placebo-controlled, longitudinal study to evaluate the effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6cf6rp	<NULL>	Will be included in the study: patients clinical diagnosed with Alzheimer&apos;s disease by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM, fourth edition), National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and Alzheimer&apos;s Disease and Related Disorders Association; Patients who have a score 1 or 2 in the Clinical Dementia Rating (CDR), characterizing mild and moderate stages of AD, respectively; Patients who are using Alzheimer’s disease FDA-approved drug for at least six months, prescribed by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital; Patients who have 60 years old or older; Education: everybody could be included in this study, but the years of education must be considered to memory score tests; adjustments should be made in accordance with the scholarity;  Do not include prescription of drugs with central nervous system action in the first six months of treatment, unless strictly necessary conditions and it must be highlighted in the patient evolution; Agreement with and signing of the informed consent form; Having a caregiver (familiar member or formal caregiver) who is responsible for the patient&apos;s participation in the study.	Will be excluded in the study patients who don’t have a clinical diagnosis of Alzheimer&apos;s disease; patients who have a score 3 in clinical dementia rating, i.e. late stage dementia; patients who suffer from diseases that may have contraindications for the use of lithium carbonate, as: kidney failure; patients who have a lithium intolerance; patients who have used lithium for other conditions;  patients with lithium serum levels above the acceptable range, i.e. 1.2 mEq/ L in plasma; patients with renal failure; patients with hypothyroidism or goiter, if not controlled; violation of the protocol; loss of follow-up; discontinuing treatment; by request of patient or caregiver; death; patients who don’t agree to participate in the study. Notes: Frequent and prevalent comorbidities in the elderly are not considered exclusion criteria, such as hypertension, diabetes, vitamin B12 deficiency, among others. These patients will be enrolled in the study with appropriate notes and the possible differences observed in these patients will be compared with normal elderly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8f6qsw	self-care effect in patients with shoulder pain	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	522	Self-care effect in the medication and function of patients with shoulder pain indicated to physiotherapeutic treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8f6qsw	<NULL>	shoulder pain for more than three months; age above 18 years; patients on the waiting list for physical therapy treatment of shoulder painful conditions in the city of Ribeirão Preto.	systemic diseases; inflammatory diseases; uncontrolled hypertension, frozen shoulder; joint instability; malignancy; shoulder surgery in the last six months; people unable to perform self-care; people unable toanswer the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-46487k	The impact of educational videos to teaching of the Leprosy disease to medical students.	Data analysis completed	Intervention	2015-06-23	<NULL>	<NULL>	523	Educational virtual objects assessment inserted in learning based on team (team-based learning) in leprosy education on undergraduate medical setting	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-27	Universidade Federal do Mato Grosso do Sul (UFMS)	Universidade Federal do Mato Grosso do Sul (UFMS)	https://ensaiosclinicos.gov.br/rg/RBR-46487k	<NULL>	94 Healthy volunteers; both genders; age greater than 18 years.	Student who already had take part on dermatologic research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-57355w	Evaluation of a new protocol of neuromuscular electrical stimulation.	Data analysis completed	Intervention	2015-06-23	<NULL>	<NULL>	524	Evaluation of safety and feasibility of a neuromuscular electrical stimulation protocol in ICU: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-18	Associação Teresinense de Ensino SC LTDA	Paulo Eugênio Silva	https://ensaiosclinicos.gov.br/rg/RBR-57355w	<NULL>	"Patients older than 18 years undergoing  mechanical ventilation; APACHE II Score higher than 13. 

Target sample of 40 patients."	"Pregnancy; obesity (body mass index &gt;35 kg/m2); preexisting neuromuscular disease (e.g. myasthenia Gravis; Guillain-Barré disease); diseases with systemic vascular involvement such as systemic lupus erythematosus; bone fractures
or skin lesions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-2x8wqc	Evaluation of a therapy for the treatment of constipation in infants.	Recruiting	Intervention	2015-06-24	<NULL>	<NULL>	525	Randomized clinical trial double-blind efficacy of Prebiotics in Chronic Constipation Funcinal in infants	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-16	Universidade Federal de São Paulo	SKL Functional Nutrition	https://ensaiosclinicos.gov.br/rg/RBR-2x8wqc	<NULL>	"Infants attending for the first time in the Department of Ambulatory Pediatric Gastroenterology at UNIFESP - EPM;
Hypothesis diagnosis of chronic functional constipation;
Infants (children under two years old);
Infants of both genders; 6-24 months;
Infants artificial feeding
(over six months old)."	"Infants with clinical signs and symptoms suggestive of Hirschsprung&apos;s disease, including: delay in the elimination of meconium, growth retardation, abnormalities in skin pigmentation, presence of extra-intestinal symptoms and lack of response to conventional treatment (Aguirre et al, 2002 );
 infants who had an organic cause of constipation, secondary to other pathologies, such as deformities in the gastrointestinal tract, hypothyroidism, rickets, malnutrition, Chagas disease or neuromuscular diseases (Cury, 2005);
Infants who present False constipation;
Infants who have anemia or iron deficiency are iron therapy with ferrous sulfate;
Hypothesis diagnosis of chronic functional constipation discarded after the first week of observation in the study;
Regular use over the past thirty days, dietary fiber supplement;
Chronic use of medications that act on intestinal motility and cause constipation (prokinetics, antacids, anticonvulsants, diuretics, hematin, antispasmodics, anti-inflammatories), with the exception of ferrous sulfate;
Need other therapeutic interventions;
Infants who had poor nutritional status, malnutrition or obesity;
Children living in cities or neighborhoods whose distance to the clinic or family socioeconomic conditions that preclude their attendance at scheduled follow-up visits;
Infants who were exclusively breastfed or mixed;
Infants who make use of formulas containing prebiotics;
Parents or guardians illiterate, who can not help of another person literate in child care during follow-up project;
Not responsible for the child&apos;s consent to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-5zy6vw	Effect of varicocele correction surgery on the quality of sperm	Recruiting	Intervention	2015-06-24	<NULL>	<NULL>	526	"Varicocelectomy effect on the spermatic DNA fragmentation: clinical trial
with random assignment of participants"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-10	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5zy6vw	<NULL>	Men with varicocele in grades II and III; aged between 18 and 45; not having undergone previous varicocelectomy.	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-84b9cd	Effect of clonidine on the target dose of propofol: bispectral index evaluation	Data analysis completed	Intervention	2015-06-25	<NULL>	<NULL>	527	Effect of clonidine on the target dose of propofol: bispectral index evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-84b9cd	<NULL>	"Patients ASA I or II.
Scheduled for laparoscopic cholecystectomy or jaw fracture treatment in Cariri Regional Hospital. Signing the consent form.
Age between 15 and 65 years. Sample : 51 patients."	"Drug users who can interfere in the outcomes.
Drug Addicts.
Physical state above two.
Refusal to sign the Instrument of Consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8sbbvp	Efect of Resistance Exercise Volume on Body Composition, Physical Performance, Metabolic, Hormonal and Inflammatory Profile in Postmenopausal Pre Sarcopenic Women	Recruitment completed	Intervention	2015-06-25	<NULL>	<NULL>	528	Sarcopenia: prevalence, disability and intervention in Postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-01	Universidade Federal do Triângulo Mineiro	Departamento de Ciências do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-8sbbvp	<NULL>	34 postmenopausal healthy women with the last period of menstruation more than a year and age more than 50 years; no hormone replacement therapy; no resistance exercise practitioners or similars; no vegetarians or tabagist; no gynecologic disease; diabetes or cardiac; no regular use  medicine (aspirine or antibiotics) and no alcoholic.	Women period previous of menopause and age less than 50 years; hormone replacement therapy users; resistance exercise practitioners or similars; vegetarians or tabagist; with gynecologic disease; diabetes or cardiac disease; regular use  of medicine (aspirine or antibiotics) and alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6y5dcb	Homeopathy versus Sertraline for depression	Recruiting	Intervention	2015-06-25	<NULL>	<NULL>	529	Homeopathy versus Sertraline	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-05	Unidade de Saúde Escola da Universidade Federal de São Carlos	Unidade de Saúde Escola da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6y5dcb	<NULL>	Subjects should meet the criteria for a depressive episode (single or recurrent) following a Structured Clinical Interview,SCID; capacity and willingness to give informed consent and to comply with study procedures will also be required.	Dysthymia; psychotic, chronic or double depression; intolerance to sertraline or a negative previous experience with the drug; bipolar disorder; schizophrenia or other psychotic disorders;  substance dependence (except tobacco); bulimia or anorexia, clinical significant chronic disease that could hinder study visits or depression evaluation;  suicide attempt up to 12 months before screening; treatment with antidepressants or mood stabilizers 4 weeks prior to the screening; homeopathic treatment 8 weeks prior to study entry; psychotherapy, meditation or acupuncture during the study; participation in a previous clinical trial 3 months prior to screening; concomitant pregnancy or breastfeeding; epilepsy;  concomitant use of anticoagulants; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6dwy85	Comparison of physiological responses between different functional tests in obese	Data analysis completed	Observational	2015-06-25	<NULL>	<NULL>	530	Reproducibility of maximum and submaximal exercise tests in obese subjects using a gas analyzer by telemetry system	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-01	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-6dwy85	<NULL>	Individuals of both sexes, different degrees of obesity; I, II and III, aged between 18 and 60 years, sedentary or active, no deficit in the locomotor system and or changes in the reported balance or detected on physical examination and spirometric function preserved; FVC&gt; 80%	Exclusion was determined when the testing protocol is not finalized within the given deadline, difficulty in understanding and carrying out the tests or when and musculoskeletal limitations or pain prevented the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-7g5vph	Evaluation operative groups to promote healthy habits with elderly diabetics	Recruitment completed	Intervention	2015-06-26	<NULL>	<NULL>	531	Promoting healthy habits with elderly diabetics: evaluation of operating groups as a therapeutic intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-05	Universidade Federal de Pernambuco (UFPE)	Universidade Federal de Pernambuco (UFPE)	https://ensaiosclinicos.gov.br/rg/RBR-7g5vph	<NULL>	202 Persons aged 60 years; both sexes; diagnosis of diabetes mellitus explained in the records of the Family Health Units that make up the MR 4.2 of Recife / PE.	Institutionalized elderly; Handicap; commitment to communication and / or cognition recorded in records; chronic complications in advanced stages (hemodialysis; amaurosis; sequelae of stroke / heart failure; active ulcer or previous amputations of lower limbs); limited mobility that can restrict access to Family Health Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-3h7f9k	Investigation of the effect of phytosterol consumption (plant extract) on the levels of cholesterol and blood fractions in children and adolescents with abnormal lipid levels in the blood treated at a university hospital.	Recruiting	Intervention	2015-06-26	<NULL>	<NULL>	532	Investigation of the therapeutic effect of phytosterol on LDL-cholesterol concentrations in dyslipidemic children and adolescents in a university hospital, randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-28	Hospital Universitário Pedro Ernesto/Universidade do Estado do Rio de Janeiro (UERJ)	Hospital Universitário Pedro Ernesto/Universidade do Estado do Rio de Janeiro (UERJ)	https://ensaiosclinicos.gov.br/rg/RBR-3h7f9k	<NULL>	dyslipidemic children and adolescents; both genders; aged 6 to 19 years, patients arising from the Outpatient Nutrition in Pediatrics and the Center for Studies of the University Hospital Adolescent Health Pedro Ernesto; plasma lipid values equal to or greater than 170 mg / dL for total cholesterol after they followed the diet less than seven percent saturated fat and total energy intake less than 200 mg cholesterol per day for a minimum period of four months.	volunteers with preexisting cardiovascular disease; metabolic diseases associated with dyslipidemia; any endocrine disorders. Children and adolescents who present triglyceride levels above 300 mg; use of food or any medications that may cause changes in the lipid profile; pregnant adolescents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-5frcz9	Study of lower dentures retained by one or two implants	Recruitment completed	Intervention	2015-06-29	<NULL>	<NULL>	533	Mandibular overdentures retained by one or two implants: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-15	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5frcz9	<NULL>	"Adults; full Edentulism in mandible and maxila for at least one year; mentally agile and responsives; sufficient bone height (at least 15 mm)
and bone width (at least 6 mm) in the
interforaminal region."	History of radiation in head and neck; risk of bacteremia (immuno-suppressed, steroid use, prosthetic heart valves); diabetes type I and II; use of tobacco, drugs or alcohol; cardisc pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9jknqq	Assessment of preventive use of non steroidal antiinflammatory on increased pain sensibility  after third molar extraction	Data analysis completed	Intervention	2015-06-29	<NULL>	<NULL>	534	Assessment of preemptive use of non steroidal antiinflammatory on hyperalgesia after third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-13	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9jknqq	<NULL>	Patients older than 18 years who agree to participate in research, with good general health,  without any medicine intake in the last 15 days (except contraceptives),  patients who have indicated bilateral extraction of impacted lower third molar, in similar conditions on both sides.	Patients who do not want to participate in the study, patients who have used any drug in the last 15 days (except contraceptives), pregnancy, breastfeeding, and presence of pericoronitis related to lower third molar, patients who report history of allergies or adverse drug effects used in the study, actual or past history of ulcer disease or gastrointestinal bleeding, renal failure, advanced liver disease and coagulopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9f7f9p	Knowledge, attitudes and contraceptive practices	Recruitment completed	Intervention	2015-07-03	<NULL>	<NULL>	535	Knowledge, attitudes and contraceptive practices - a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Faculdade de Enfermagem - Universidade Estadual de Campinas	Faculdade de Enfermagem - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9f7f9p	<NULL>	Both sexes; age between 10 and 19 years old; students at day classes.	Do not signing the Informed Consent Form, by the parents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-5vr3vt	Pilates and therapeutic exercises are effective for the treatment of low back pain?	Data analysis completed	Intervention	2015-07-06	<NULL>	<NULL>	536	Effectiveness of mat Pilates and therapeutic exercise in the treatment of chronic nonspecific low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-29	Universidade Paulista UNIP	Clínica Luz Fisioterapia LTDA. ME.	https://ensaiosclinicos.gov.br/rg/RBR-5vr3vt	<NULL>	Patients with low back pain lasting symptoms from at least three months; aged between 18 and 60 years.	Practitioners of Pilates; pregnancy; history of fractures of the spine; inflammatory disorders; tumors; severe neurological impairment; inability to speak or write in Portuguese; pretreatment physical therapy for chronic non-specific pain in the last	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-27kdyf	Light therapy and electrical stimulation on functional performance in volleyball athletes	Recruiting	Intervention	2015-07-06	<NULL>	<NULL>	537	Low level laser therapy and neuromuscular electrical stimulation on knee extension strength and jump in volleyball athletes: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27kdyf	<NULL>	Healthy volunteers; volleyball players; gender male; non-smoking; aged between 17 and 18; weight within 15% variation limit of normal weight for male athletes, taking into account height and physique.	smoking volunteers; history of alcohol or substance abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9qjgsf	Pathogenicity of Candida species identified in denture  after the use of cleansers solutions	Recruiting	Intervention	2015-07-07	<NULL>	<NULL>	538	Expression of virulence genes and virulence factors of Candida species identified in dentures biofilm after using cleansers solutions.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-13	Faculdade de Odontologia de Ribeirão Preto FORP/USP	Faculdade de Odontologia de Ribeirão Preto FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-9qjgsf	<NULL>	Patients with stomatitis Prosthetics; use of conventional dentures; base and artificial teeth in acrylic resin; at least use time one year; appropriate conditions of prostheses; presence of biofilm on the inner surface of the prosthesis.	Prostheses with problems in adaptation; reline; repair or fractures; Use of antifungals; antibiotics or steroids in the past 3 months; anemia; immunosuppression or cancer therapy; other immunosuppressive diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4fxqw5	Analysis of memories about injuries in the football in adolescents	Data analysis completed	Observational	2015-07-09	<NULL>	<NULL>	539	Analysis of recall bias information about injuries in the football  in adolescents	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-07-30	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4fxqw5	<NULL>	Aged 12 and 18 years; male gender; they make effective portion of the sports season (this year).	Inability to practice sports physical activity in the past six months; refuse to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-6qbztf	Biomaterials for preventing sensibility after home bleaching	Not yet recruiting	Intervention	2015-07-09	<NULL>	<NULL>	540	"Randomized clinical trial of the nano-hydroxyapatite and arginine effect for the 
dentin sensibility prevention after bleaching home treatment"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6qbztf	<NULL>	"60 people aged between 18 and 26 years;
any genders; good health; non-moking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic 
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-5g79z8	Treatment of gingival diseases with laser and dye in Down Syndrome patients	Recruitment completed	Intervention	2015-07-11	<NULL>	<NULL>	541	Antimicrobial  photodynamic therapy for periodontal disease treatment in patients with Down Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-5g79z8	<NULL>	Have a diagnosis of Down syndrome; be between the ages of ten to sixty years;does not have moderate to severe hearing loss that would impair communication and therefore the dental care; do not present severe visual problems that could impair the performance of the proposed procedures;presence of at least 4 (four) teeth in the oral cavity, with at least one teeth per hemiarch (excluding third molars); patients diagnosed with infectious periodontal disease.	"Smokers;chronic use of alcohol (alcóolatras);
women undergoing menopause; pregnant or lactating women; edentulous patients; uncontrolled Diabetes mellitus; uncontrolled Hyperthyroidism; unstable Angina pectoris;
severe untreated or uncontrolled Hypertension  (PA&gt;200/115mmHg); illicit drug users."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-6vkcb7	Effects of an Educational Action on Knowledge and the Cardiovascular Health Behavior of Men Metallurgical	Data analysis completed	Intervention	2015-07-13	<NULL>	<NULL>	542	Evaluation of an educational program on injury prevention cardiovascular diseases on human health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-18	Universidade Estadual de Maringá	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-6vkcb7	<NULL>	135 metallurgical workers were evaluated and the inclusion criteria for the evaluation are: being male; be aged between 18 and 70 years; being actively working on a metallurgical company selected in Metropolitan area of maringá-PR	Being out of the company and/or vacation during the recruitment period;refuse to participate in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-6crdyx	Effects of metformin at high pressure and mild hypothyroidism	Recruitment completed	Intervention	2015-07-13	<NULL>	<NULL>	543	Non antihyperglycemic effects of metformin on blood pressure and subclinical hypothyroidism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-14	Hospital de Clínicas de Porto Alegre - UFRGS	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6crdyx	<NULL>	Volunteers of both sexes; aged between 18 and 65; with TSH greater than the upper limit of normal for the method in two steps, the first by any method and the second measured by chemiluminescence accompanied by free T4 levels within normal limits.	Previous diagnosis of type 2 diabetes; use of levothyroxine; contraindications to the use of metformin; known abnormal liver function; heart failure NYHA III-IV despite optimal drug therapy; serious mental illness; any terminally ill; malignancy not cured or in treatment; contrast studies in the last three months; use of medications known to interfere with thyroid function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9p5q67	Land and aquatic strength exercises for obese old women with muscle weakness.	Data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	544	Land-based versus aquatic resistance therapeutic exercises for old women with sarcopenic obesity: a randomized trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9p5q67	<NULL>	Female gender; age from 65 to 80 years; obesity (body mass index equal or more than 30 kg/m2); sarcopenia (hand-grip strength equal or lower than 21 kilograms)	Physical, sensory or cognitive disfunctions that do not allow participation in the exercise programs; cardiovascular, articular or metabolic disease in acute phase or not clinically controlled;urinary or fecal incontinence; contagious dermatologic diseases; open scars; physical therapy for lower limbs; fracture or surgery for lower limbs in the last 12 months; severe venous insufficience.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-69t579	Study of heart and breath during the prosthesis hip setting about raquianesthesia	Not yet recruiting	Observational	2015-07-14	<NULL>	<NULL>	545	Study of haemodynamic repercussion across the cardioimpedance during the use of methylmethacrylate in total Hip Arthroplasty about Raquianesthesia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-69t579	<NULL>	Volunteers with Hip ostheoarthrosis diagnosis; above 65 years old;both gender	Anemia; diagnosis of asthma or pulmonary disease, cardiac	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-88hf2c	Local control of bleeding in patients post-extraction measures that make use of oral anticoagulants	Recruitment completed	Intervention	2015-07-15	<NULL>	<NULL>	546	Local measures of hemostasis after tooth extractions in patients taking oral anticoagulants	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Departamento de Odontologia	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-88hf2c	<NULL>	Constant users of oral anticoagulants; Patients who require at least one extraction; Patients with INR on the procedure between 1.5 and 4.0.	Patients who use medications that affect liver function or have any effect, either directly or indirectly in hemostasis; Patients with previous severe episodes of thromboembolism; Patients with liver diseases known; Patients who are pregnant or breastfeeding; Patients with congenital haemostatic abnormalities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4tswsq	Strength training effects with elastic tubes on muscle strength, functional capacity, inflammation and quality of life of apparently healthy individuals	Recruiting	Intervention	2015-07-16	<NULL>	<NULL>	547	Strength training effects with elastic tubing in the functional, biological variables and quality of life of apparently healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Estadual Julio de Mesquita Filho - UNESP	Universidade Estadual Julio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-4tswsq	<NULL>	Adults between 45 and 80 years;both genders; insufficiently active.	Clinical instability; cardiac disorders, musculoskeletal, neurological, pulmonary dysfunction, irregularity in the frequency of the sessions, refusal to sign the consent form, dependence tobacco.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-22t943	Impact and cost effectiveness of a protocol for diagnosis and treatment of tuberculosis in HIV/AIDS patients	Recruiting	Intervention	2015-07-16	<NULL>	<NULL>	548	Impact on mortality and cost-effectiveness of a protocol for diagnosis and treatment of tuberculosis in People Living with HIV	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-21	Conselho Nacional d eDeswenvolvimento Cientifico e Tecnologico	Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-22t943	<NULL>	HIV positive patients who were diagnosed with HIV; aged 18 years or over; and attended in Correia Picanco Hospital before initiating ART.	Being treated for TB; We have been treated for tuberculosis in the last three months; be receiving antiretroviral therapy over a month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-3kzp25	Evaluation of two preventive schemes of dental extraction with amoxicillin in patients with rheumatoid arthritis treated with tumor necrosis factor-alpha inhibitors (anti-TNF-?) and methotrexate	Recruitment completed	Intervention	2015-07-17	<NULL>	<NULL>	549	Evaluation of the effectiveness of two preventive schemes with amoxicillin for tooth extractions in rheumatoid arthritis patients treated with tumor necrosis factor-alpha inhibitors(anti-TNF-?) and methotrexate	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-3kzp25	<NULL>	"Healthy volunteers and subjects with rheumatoid arthritis who make use of inhibitors of TNF-alpha and methotrexate.Participants with aged 18 to 75 years.
Patients that signed the IC (Informed Consent)and requiring simple extractions, exhibiting in blood tests (INR- international normalized ratio less than 2.5 platelet count above the 30.000; Count leukocytes above the 2.000 per mm³ and fasting glucose lower than 126 mg/dL). This study aims to enroll about 72 patients."	Patients that used antibiotics in the last 15 days. Patients allergic to Amoxicillin (experimental group).Patients with dental infection(periodontal abscess or periapical abscess).Patients with pre-existing infection. Patients that used additional immunosuppressive medication and patients who not attended the scheduled follow and/or do not follow the instructions of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-9zggxm	Effects of the decreased carbohydrate intake in short-stature, excess weight women	Recruitment completed	Intervention	2015-07-19	<NULL>	<NULL>	550	Low-carbohydrate diet effects on women with excess weight and short-stature	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Federal de São Paulo	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-9zggxm	<NULL>	Women; age between 20 and 45 years old; height less than 152,3 cm or higher than 158,7cm; body mass index higher than 25kg/m².	Individuals in Continuous use of drugs (immunosuppressors, insulin, thyroid hormones, anti-retrovirals); pregnant or lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-7jyccp	"Biomaterials for preventing sensibility after
home bleaching"	Not yet recruiting	Intervention	2015-07-19	<NULL>	<NULL>	551	Randomized clinical trial study of effect of potassium nitrate and strontium chloride  associated to the bleaching home treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7jyccp	<NULL>	"60 people aged between 18 and 26 years;
any genders? good health; no-snmoking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-6bqsw8	Effects of different physical activities programs on osteoporosis related-variables in older women	Recruitment completed	Intervention	2015-07-21	<NULL>	<NULL>	552	Low bone mineral density related-variables in postmenopausal women, practitioners of different physical activities programs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-08	Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	Universidade do Estado do Pará (UEPA)	https://ensaiosclinicos.gov.br/rg/RBR-6bqsw8	<NULL>	Female volunteers; aged over or equal 50 years; with low BMD (T – score &lt; -1DP); different ethnic population (descendants of Europeans, Blacks and Indians); patients being treated with sodium alendronate (70 mg) and/or vitamin D3; postmenopausal women (menopause of age self-declared); no previous history of fractures; no regular practice of physical activity for at least 1 year; with indication / medical clearance for physical exercises practices.	Who made some kind of surgical procedure in the last six months; who had early menopause by ovary removal; with uncontrolled hyperteho made some sort of surgery in the last snsion; that use additional bone active medications or hormone replacement therapy and volunteers who were being treated with drugs that induces low BMD, as glucocorticoids; volunteers with excessive use for alcohol and tobacco; that were not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-9f3sm9	Balance among patients with Parkinson&apos;s disease after physical therapy intervention using Nintendo wii®	Recruitment completed	Intervention	2015-07-21	<NULL>	<NULL>	553	Evaluation of static and dynamic balance of patients with Parkinson&apos;s Disease before and after physical therapy intervention using the Nintendo Wii® the rehabilitation process	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-9f3sm9	<NULL>	to present a confirmed diagnosis of Parkinson&apos;s Disease; degree of involvement of Parkinson&apos;s Disease between 2.5 to 3.0 on the Hoehn and Yahr scale ; Being currently in service in Brazil Parkinson Association (BPA); have availability to perform physiotherapy on BPA 2 times a week for 01 months, with duration of 1 hour; make use of medicament for Parkinson&apos;s Disease.	presence of moderate to severe musculoskeletal complaints, in which the pain or deformity impossible to maintain bipedalism for extended periods, vestibular complaints; autonomic dysfunction; symptoms suggestive of cognitive changes detectable by the test Mini Mental State Examination; weigh more than 150 kg (maximum weight supported by the gaming platform).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-76xp78	Mandibular moviments evaluation and satisfaction of complete denture wearers after the use of two adhesives.	Recruitment completed	Intervention	2015-07-22	<NULL>	<NULL>	554	Electrokinesiographic evaluation and satisfaction of complete denture wearers after the use of two adhesives.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-76xp78	<NULL>	Adults; mentally agile and responsive; resilience and alveolar volume normal; absence os disfunctions in the stomatognathic system; absence of debiliting systemic changes.	Debilitating neurological os systemic diseases;cardiac pacemaker; need for pre-prosthetic surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-3hf227	Assessment of the pain level  of Benzathine Benzylpenicillin administered in the region ventrogluteal (hip) vs. dorsogluteal	Recruitment completed	Intervention	2015-07-24	<NULL>	<NULL>	555	Assessment of acceptance of intramuscular injection of penicillin in the region ventral gluteal in emergency units in Goiânia - Goiás	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-25	Faculdade de Enfermgem da Universidade Federal de Goiás	Faculdade de Enfermgem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3hf227	<NULL>	Present the prescription of Benzylpenicillin; be over 18 years old; be served in the medication room of two  Centro de Atendimento Integrais a Saúde (CAIS) of the eastern region of Goiânia.	Have an injury on the skin or muscles of the buttock; present prescription of procaine penicillin associated with Benzylpenicillin; have psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-4bdwxs	Effect of green tea and metformin on excess of sugar on the blood of obese individuals with pre-diabetes	Recruitment completed	Intervention	2015-07-25	<NULL>	<NULL>	556	Effect of green tea extract and metformin on insulin resistance in obese individuals with pre-diabetes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-15	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Faculdade de Nutricao (FANUT/UFG)	https://ensaiosclinicos.gov.br/rg/RBR-4bdwxs	<NULL>	Obese individuals (fat&gt; 30%) with pre-diabetes, women, aged 20-60 years.	Volunteers with thyroid disorders; diabetes; renal and hepatic diseases; pregnant women; nursing; in hormone replacement; under treatment for weight control; those who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-7zp9n4	Evaluation of the effects of a programme promoting adequate and healthy eating on adolescent health condiction: an interventional study	Recruitment completed	Intervention	2015-07-26	<NULL>	<NULL>	557	Strategy to promote healthy living and healthy eating style: an intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-03	Escola de Nutrição da Universidade Federal da Bahia	Escola de Nutrição da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7zp9n4	<NULL>	Adolescents aged between 10 and 17 years old; and both genders;  enrolled in public  schools in Salvador, Bahia (BA) state, Brazil	Students who refused to participate in the study; pregnant women and people with physical trauma (mobilized at the time of anthropometric measurements); Adolescents who did not participate in one of the stages of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-55kzbn	Biomechanical analysis in individuals with anterior knee pain and its treatment	Not yet recruiting	Intervention	2015-07-27	<NULL>	<NULL>	558	Morphological, neurofunctional, kinetics and kinematics analysis in individuals with patellofemoral pain syndrome and its treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-55kzbn	<NULL>	It will be included 40 participants with unilateral or bilateral patellofemoral pain; aged between 18 and 35 years; report onset of symptoms insidiously not related to a traumatic event; should have pain (at least 3 of 10 points according visual analogue scale) in retropatellar or peripatellar region at least three of the following functional activities: up or down stairs; run; kneeling; squat; stand for long periods sitting; jumping; isometric contraction of the quadriceps and palpation of the lateral and / or medial side of the patella; and the presence of pain for at least two months. Also; it will be included 40 participants without pain; aged between 18 and 35 years and they should present any history of injury or pain in the knees.	Both groups should not have history of surgery on knees; history of injury or pain in the hip; patellar instability; pain on palpation of the patellar tendon; iliotibial band or tendons of goose foot; signs or symptoms of meniscal or ligament injuries of the knee; presence of Osgood-Schlatter disease or Sinding-Larsen-Johansson syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-95xwc7	Evaluation of effects of differents montages of non invasive brain eletrical stimulation in funcionality of children with cerebral palsy of type spastic hemiparesis	Not yet recruiting	Intervention	2015-07-27	<NULL>	<NULL>	559	Effects of differents montages of tDCS in functionality of children with Cerebral Palsy of type Spastic Hemiparesis: clinical trial randomized, placebo-controlled and double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-95xwc7	<NULL>	Inclusion criteria will be thirty children who: a) have the diagnosis of CP spastic hemiparesis; functionally classified as levels I and II by GMFCS (Palisano et al, 1997;. Hiratuka et al, 2010).; have independent walking at least 12 months; the age group of six and ten years of life; have degrees of understanding and consistent collaboration with the completion of the proposed activities; The parents agree with their participation in the study by signing the Informed Consent	Children who will be excluded have undergone surgical procedures or neurolytic blocks in the last 12 months before the start of the training sessions; presenting structured orthopedic deformities with surgical indications; have epilepsy; having metal implant in the brain or hearing aids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-9bnx9m	Effects of an Exercise  Physical Program in muscle strength, cardiorespiratory fitness, cardiovascular risk and quality of life of elderly.	Recruitment completed	Intervention	2015-07-27	<NULL>	<NULL>	560	Effects of a Concurrent Training program in muscle strength, cardiorespiratory fitness, cardiovascular risk and quality of life of elderly: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-23	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bnx9m	<NULL>	Should participate 64 elderly with hypertension and diabetes mellitus; aged between 60 and 79 years; of both genders.	Seniors in use of injectable medications and insulin estaminas; uncontrolled hypertension; smokers or former smokers with cessation of tobacco less than 20 years; neurological diseases; symptomatic musculoskeletal disorders, severe obesity; malnutrition; severe kidney disease; recent history of carcinoma; heart disease than high blood pressure; lung disease; changes in cognitive behavior; physically active high intensity;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-4kdm85	Elastic bandage for postural correction	Data analysis completed	Intervention	2015-07-27	<NULL>	<NULL>	561	Effects of therapeutic elastic bandage for postural correction	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Faculdade Integral Diferencial-FACID/DeVry	Faculdade Integral Diferencial-FACID/DeVry	https://ensaiosclinicos.gov.br/rg/RBR-4kdm85	<NULL>	Sample consisting of 10 students aged between 18 and 30 years old with protraction of shoulders; thoracic hyperkyphosis and musculoskeletal pain in the thoracic region	Acute pain; chest pain associated with diseases; vestibulopatias; allergic process to bandage and participants who were performing some other type of postural treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-453vyf	Effects of early aerobic exercise after cardiac surgery	Recruiting	Intervention	2015-07-27	<NULL>	<NULL>	562	Effects of early aerobic exercise after coronary artery bypassa grafting: a randomized controlled clinical trial during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-453vyf	<NULL>	Patients undergoing elective coronary artery bypass surgery in the proposed period.	Use of intra-aortic balloon or other invasive device inserted by femoral artery;Surgical reintervention immediate postoperative period; Perioperative death; Prolonged Hospitalization above 10 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-7s6ymc	Effect of low-level laser and exercise improving balance and functionality in people with knee osteoarthritis	Not yet recruiting	Intervention	2015-07-28	<NULL>	<NULL>	563	Effect of Low-level Laser Therapy associated or not to exercise in subjects with knee osteoarthritis: randomized study on the impact of physical therapy clinical trial on postural control and functionality	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s6ymc	<NULL>	Individuals of both genders, with ages between 40 and 70 years, with or without knee osteoarthritis.	Cardiovascular disease; neurological or musculoskeletal that disables the volunteer to perform exercises; evidence of secondary disease, inflammatory or metabolic; osteonecrosis and previous intra-articular injection; surgery in the previous three months to inclusion in the study or use of drug treatment that could potentially have an effect on the results of study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-5x4dc9	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	Data analysis completed	Intervention	2015-07-28	<NULL>	<NULL>	564	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-26	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5x4dc9	<NULL>	180 Volunteers with asthma poorly or partially controlled as defined by GINA (Global Initiative for Asthma); aged between 18 and 65; who had inhaled corticosteroid prescription for daily use by the attending physician.	Patients unable to use the inhaled drug due to motors or mental problems; with other lung diseases diagnosed or reported; who can not perform spirometry, unable to properly use the homemade or commercial spacers after watching educational film three times; patients who refuse to participate and sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-2n5mtq	Clinical and electromyographic follow-up of patients taking riluzole and lithium carbonate - A randomized controlled trial	Recruitment completed	Intervention	2015-07-28	<NULL>	<NULL>	565	Clinical diffusion, neurophysiological progression and prognosis of patients with Motor Neuron Disease undergoing Riluzole and Lithium Carbonate - A Randomized Controlled Trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2014-02-12	Secretaria de Estado de Saúde do Distrito Federal	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2n5mtq	<NULL>	"Age over 18 years; no upper limit;
Disease diagnosis Motor Neuron possible, probable or definite;
Exclusion of other diseases by MRI skull and marrow and electromyography;
Forced Vital Capacity over 50%.
Size of the target sample:100"	"FVC less than 50%
other diseases exclusion"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-96t463	Use of platelet eyedrops in diabetic patients with dry eye disease.	Recruitment completed	Intervention	2015-07-28	<NULL>	<NULL>	566	Use of platelet-rich plasma in diabetic patients with dry eye disease.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Hemocentro de Alagoas-HEMOAL	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-96t463	<NULL>	Diagnose of diabetes following ADA (American Diabetes Association)criteria;moderate or severe dry eye patients with unresponsiveness or a weak response to conventional treatment; having at least a frequent or constant symptom and either a Schirmer test at less than 15mm or a BUT(Break Up Time test) less than 10 seconds.	Individuals under 18; mentally disabled; pregnant women; indigenous people and those who are wards of the state. Patients that had keratopathies; use of glaucoma eyedrops; previous rheumatic disease diagnosis. Patients that had contraindicated conditions to be submitted to autologous donation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-99395b	Control of hormone concentrations produced by the stomach and intestine by the use of a supplement containing yerba mate, guarana and damiana in women with overweight	Recruitment completed	Intervention	2015-07-30	<NULL>	<NULL>	567	Modulation of gastrointestinal hormones by supplementation herbal extract containing yerba mate, guaraná and damiana in overweight women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Universidade Federal de Goiás	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-99395b	<NULL>	BMI 25 and 39,9 kg/m²;20 Sedentary women and healthy;Aged 20 to 50 years	Unavailability of one day/ week for the study day;participants with autoimmune liver kidney or hypothyroidism diseases; gastrointestinal symptoms requiring treatment; bariatric surgery;participants of a food restriction program or that practiced diet in the last 12 months to lose or control weight;without use current adherence to a specific food avoidance diet;taking medication or nutritional supplements known to affect appetite or weight;taking medication immunosuppressive or insulin; being pregnant or planning to become pregnant or breastfeeding; menopause;chronic alcoholics;history of anaphylaxis to food; food allergies, including caffeine or other compound present in the supplement and any of the study foods;intolerance or allergy to lactose	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-7m2756	Effect of an exercise program on cardiopulmonary function and quality of life in patients after gastric bypass surgery	Not yet recruiting	Intervention	2015-07-30	<NULL>	<NULL>	568	Impact of an exercise program on cardiopulmonary function, functional capacity and quality of life in patients undergoing Bariatric Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7m2756	<NULL>	Obese patients who are part of the Surgery of Obesity and Related Disorders (SCODE) of HUOL and UFRN; target sample of 24 subjects; having a BMI above 30 kg / m2; both genders; aged between 18 and 50 years; presented FVC and FEV1 values above 80% of the predicted age obtained in spirometry; signed an informed consent form.	Cognitive and / or neurological disorders; orthopedic impairments; diagnosis of chronic obstructive pulmonary disease (COPD) and / or severe cardiovascular disorders such as unstable angina, valvular heart disease, acute arrhythmias, acute myocardial infarction in the last month, high blood pressure and / or uncontrolled diabetes mellitus; presence of cardiac pacemakers; patients who present contraindications to perform the Cardiopulmonary Exercise Test III Guidelines established by the Brazilian Society of Cardiology About Exercise Stress Test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-57hj7n	Effects of supplementation with L-carnitine in the heart of patients who will do coronary artery bypass graft	Recruiting	Intervention	2015-07-30	<NULL>	<NULL>	569	Effects of supplementation with L-carnitine on ischemia and reperfusion and left ventricular function and remodeling in patients with heart failure after coronary artery bypass surgery	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Universidade Federal Fluminense	Instituto Nacional de Cardiologia/INC	https://ensaiosclinicos.gov.br/rg/RBR-57hj7n	<NULL>	Sixty adult patients; lucid; oriented; both genders; minimum age of 30 years and maximum age of 80 years; diagnostic systolic ischemic heart failure; requiring elective coronary artery bypass surgery; use of cardiopulmonary bypass (CPB); Ejection fraction of the left ventricle (LVEF) greater than or equal to 50% (Simpson method); left ventricular end-diastolic volume (LV Diastolic) greater than 150 mL / m²; end of the left ventricle systolic volume (LV Systolic) greater than 65 ml / m².	During treatment develop liver dysfunction; renal dysfunction; malabsorptive syndrome; stroke; sepsis; prolonged hemodynamic shock; Patients who discontinue supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-4z26f3	Assessment of bucket bath in newborn	Recruitment completed	Intervention	2015-07-30	<NULL>	<NULL>	570	Behavioral effects of the bucket bath in newborn	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Faculdade de Ciências da Saúde do Trairí	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4z26f3	<NULL>	100 Newborn term with 1-3 days of life; both genders; with clinical stability; With informed consent and informed consent signed by the person responsible.	Neonates requiring ventilatory support with infectious processes; open wounds or unhealed; temperature changes; neurological problems; heart failure and seizures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-5zmg23	Immediate effects of manual therapy on balance and movement of people with Parkinson´s disease	Recruitment completed	Intervention	2015-07-30	<NULL>	<NULL>	571	Immediate effects of an approach in high cervical and occipitomastoid on postural controle and mobility of individuals with Parkinson´s disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-02	Centro Universitário Franciscano	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-5zmg23	<NULL>	"Sample size - 3;
Individuals with idiopathic Parkinson´s disease; 
both gender;
aged between 50 and 80 years;
preserved cognitive function (Mini Mental Status Examination – MMSE);
stages among 2.5 and 4 points in Modified Hoehn and Yahr scale and;
capacity to stand and ambulate independently."	"Individuals with uncorrected visual deficit; other neurologic disease;
use of assistive devices;
musculoskeletal, cardiovascular or respiratory disease that could pose a risk and interfere in the accomplishment of the evaluation and intervention;
fracture on cervical spine or on base of the skull;
individuals with history of intracranial hemorrhage and brain aneurysm or;
did not agree to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-9gh4km	Impact of a program of global exercises on balance and memory of subjects with Mutiple Sclerosis	Recruiting	Intervention	2015-07-31	<NULL>	<NULL>	572	Effects of cognitive-motor rehabilitation in patients with Multiple Sclerosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9gh4km	<NULL>	Thrity volunteers of both gender; diagnosis of Multiple Sclerosis; age above 18 years.	Refusal to participate; exacerbation of symptoms of Multiple Sclerosis during treatment; cognitive decline; imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2xzcwz	Homeopathy in the cocaine-crack dependence.	Recruiting	Intervention	2015-08-02	<NULL>	<NULL>	573	Homeopathic potencies of Opium and Erythroxylum coca  in the integrative treatment of cocaine dependence: randomized, parallel group, placebo controlled, double-blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-25	Unidade de Saúde Escola (USE) da Universidade Federal de São Carlos/UFSCAR	Centro de Atenção Psicossocial Álcool e Drogas de São Carlos-SP	https://ensaiosclinicos.gov.br/rg/RBR-2xzcwz	<NULL>	104 patients who meet the criteria for cocaine dependence from the International Statistical Classification of Diseases and related health problems 10th revision - World Health Organization.  Fixed address; capacity and willingness to give informed consent and to comply with study procedures were also required.	Cocaine abstinence at inclusion interview; disabling clinical or psychiatric diseases that would hinder regular participation in the study. Acupunture or homeopathic treatment simultaneously to the study; simultaneous participation in another clinical trial; pregnancy; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures. Patients that after inclusion and first medical visit do not return for any visit will be excluded and their data will not be used for statistical analysis only for &quot;lost to follow-up&quot; total. Motivation for change will be briefly assessed and subjects in precontemplation or contemplation states regarding cocaine and/or crack dependence will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-88mkk2	Immersion cold water after the physical exercise reestablishment	Recruitment completed	Intervention	2015-08-03	<NULL>	<NULL>	574	Effects of systematic application of cold-water immersion in post-exercise recovery in high-performance athletes	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-27	Universidade Estadual Paulista (FCT/UNESP)	Universidade Estadual Paulista (FCT/UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-88mkk2	<NULL>	10 high performance athletes; male; athletes; aged between 18 and 30 years.	Smokers volunteers; use of medications that affect autonomic activity of the heart as for example beta blockers and angiotensin converting enzyme inhibitors; alcoholics; Use of chronically inflammatory drugs such as for example betamethasone; Diagnosis of metabolic disorders and/or endocrine known, for example, diabetes mellitus and dislipedemia; and are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-695twt	Treatment with electrotherapy on sleep quality in postmenopausal women with urinary urgency complaints and sleep interrupted by the urge to urinate	Recruiting	Intervention	2015-08-07	<NULL>	<NULL>	575	Effects of electrical stimulation of the posterior tibial nerve on sleep quality in postmenopausal women with symptoms of overactive bladder and nocturia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-02	Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-695twt	<NULL>	They will be included 40 postmenopausal women (over 12 months of amenorrhea); aged between 40 and 90 years; presenting urinary urgency and nocturia.	Women with postmenopausal time less than 12 months; presenting apnea; restless legs syndrome; mild to severe depression and mild to severe anxiety; heart disease uncontrolled; presence of prolapse of pelvic organs; presence of pelvic pain; history of pelvic surgery, except cesarean surgery; uterine bleeding; inflammation and / or urinary tract infection; diabetes mellitus; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-4bvwxq	Transcutaneous Electric Nerve Stimulation Effect in Parkinson&apos;s Disease	Recruiting	Intervention	2015-08-11	<NULL>	<NULL>	576	"TENS Effect in Parkinson&apos;s Disease:
Randomized Clinical Essay"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4bvwxq	<NULL>	Inclusion criteria comprehend:subjects of both sexes and aged between 50 and 80 years; presence of motor fluctuations; conventional antiparkinsonian therapy excluding amantadine , clozapine, deep brain stimulation or pallidotomy and previous thalamotomy; ability to remain standing for at least 10 minutes; ability to walk independently with or without assistive devices; complaint of pain in the spine, with the presence or absence of irradiation to limbs and characterized as neuropathic (continuous and diffuse spontaneous pain, sensory loss, allodynia and hyperalgesia). Targer sample 80 patients.	Subjects will be excluded if: the medical or physical examination scores below 24 on the Mini Mental State Examination; there are systemic conditions, such as heart disease, that would interfere with the participation in the study; there is musculoskeletal damage or excessive pain in any joint that may limit participation in an exercise program; there is psychiatric disorder, cognitive decline or dementia influencing the communication process; there is musculoskeletal, cardiopulmonary or neuromuscular disorder ,recent or unresolved, which may affect their ability to walk or mobility; they are under physiotherapeutic treatment during the period of training; there is presence of contraindications for use of TENS, such as ulcerations or allergy to the material; there was previous use of TENS; there is chronic use of opioids or antidepressants; there is use of a cardiac pacemaker; there is reduced sensitivity at sites where the electrodes will be placed; there was previous back surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9h7ckx	Consumption of fruits and vegetables in promoting health services	Recruitment completed	Intervention	2015-08-12	<NULL>	<NULL>	577	Consumption of fruits and vegetables in promoting health services in Belo Horizonte, Minas Gerais: associated factors and nutritional interventions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-10	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de São João del-Rei - UFSJ	https://ensaiosclinicos.gov.br/rg/RBR-9h7ckx	<NULL>	Members of the Academia da Saúde Program; both genders; aged between 20 and 90 years.	Pregnant; mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-22bpsb	Influence of a Pilates exercise program on bone mass in elderly sedentary	Recruitment completed	Intervention	2015-08-12	<NULL>	<NULL>	578	Influence of a Pilates exercise program on bone mass in elderly sedentary	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-22bpsb	<NULL>	"Age between 60 and 69 years old; female; be sedentary.
Size of the target sample: 24"	Being a smoker; have serious neurological and musculoskeletal disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-8hfcz8	An exercise program for diabetic elderly based on impairment of feet and its influence on the balance	Recruitment completed	Intervention	2015-08-13	<NULL>	<NULL>	579	An exercise program for diabetic elderly based on sensoriomotor changes of feet and their repercussions in the balance: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-03	Centro de Ciências da Saúde da Universidade Estadual de Maringá	Centro de Ciências da Saúde da Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8hfcz8	<NULL>	Elderly; above 60 years old; Diabetes Mellitus type II;  independent for activities of daily living.	Elderly with neurological consequences; vascular diseases; great alterations of balance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2fbqp5	Swallowing and its implications on nutritional status and inflammatory markers	Recruiting	Observational	2015-08-13	<NULL>	<NULL>	580	Swallowing and its implications on nutritional status and inflammatory markers	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-09	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2fbqp5	<NULL>	Experimental group with 100 patients with age equal or higher than 19 years; both sexes; without a diagnosis of cancer; without treatment with antibiotics and anti-inflammatory 30 days before collection. Control group healthy volunteers; eutrophic; matched for age and sex with the study group.	Experimental group excluded smokers; patients with fever; diagnosis of edema; cancer; individuals on antibiotics; nonsteroidal anti-inflammatory drugs; immunosuppressants; antihistamines; corticosteroids; chemotherapy; radiotherapy within 30 days before collection of datos.Grupo control excluded patients with pulmonary diseases; cardiovascular; degenerative; neurological; arthritis; cancer; diabetes; smokers; pregnant women and women in the menstrual period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-63xqkg	Evaluation of lower limb motor function and balance between 2 rehabilitation protocols using the technique of Used Forced Therapy  at post stroke	Data analysis completed	Intervention	2015-08-13	<NULL>	<NULL>	581	Functional and stabilometric correlates between two Forced Use Therapy protocols in lower limb rehabilitation of patients with Chronic Hemiparesis Post-Stroke	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro Integrado de Reabilitação do Hospital Estadual de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-63xqkg	<NULL>	"Subjects post stroke; 18 until 90years; good cognition; no joint locks; good range of motion in the arm with a minimum of 20 ° of active wrist extension and 10 ° at the metacarpophalangeal joint; ability to walk without assistance.
Sample Target: 36 subjects"	Subjects with: cardiac arrhythmias; uncontrolled hypertension;  severe cardiovascular problems;  severe breathing and inability to attend the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-92mmc7	Changes in vitamin D metabolism in HIV-infected patients.	Recruitment completed	Intervention	2015-08-14	<NULL>	<NULL>	582	Vitamin D, Immune Activation and Metabolic Changes in HIV-Infected Patients using Antiretroviral Therapy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-22	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-92mmc7	<NULL>	HIV-infected men and women aged 18 years or more; having HIV-1 RNA &lt; 50 copies / mL proven with their current antiretroviral regimen (within the 24 weeks prior to study entry); participants should receive HIV primary care in the Evandro Chagas Research Institute (IPEC) at the time to study entry; participants should have capacity and willingness to sign the written informed consent prior to the initiation of the study procedures.	Persons receiving vitamin D supplementation &gt; (not including standard multivitamin once a day);  HIV-infected persons not in use antiretroviral therapy; HIV-infected persons without viral suppression with their current antiretroviral regimen (HIV-1 RNA&gt; 50 copies/mL within the 6 months prior to screening).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-4hrrsr	Influence of knee pain on kinematics of knee,ankle and foot during stair descent and immediate effects of an intervention	Other	Intervention	2015-08-15	<NULL>	<NULL>	583	Influence of Patellofemoral Pain Syndrome on 3D kinematics of knee,ankle and foot during stair descent and immediate effects of an intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-20	Escola de Eduacação Física e Esporte da Universidade de São Paulo	Escola de Eduacação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4hrrsr	<NULL>	The inclusion criterias are pain in the patellofemoral joint region for at least two months during squatting, prolonged sitting, descending or ascending stairs.	Any previous knee surgery, history of patellar dislocation or any other limitations that would influence gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2cctcn	Study with use of gastrin releasing peptide in children with autism	Data analysis completed	Intervention	2015-08-17	<NULL>	<NULL>	584	Experimental Study of a Case Series of Gastrin-releasing Peptide use in Pediatric Patients with Autism	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-03	Fundo de Investimento a Pesquisa e a Eventos do Hospital de Clínicas de porto Alegre	Fundação Sul-Americana para o Desenvolvimento de Drogas Anti-Câncer	https://ensaiosclinicos.gov.br/rg/RBR-2cctcn	<NULL>	Diagnosis of infantile autism by the criteria of the Diagnostic and Statistical Manual of Mental Disorders, aged between 3 and 18; CT scan or MRI of normal brain; karyotype and normal research Fragile X;	"Conditions associated with an increased acid secretion in the gastrointestinal tract such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis; diabetes; heart disease;
 residence outside of Porto Alegre and the metropolitan area; secondary autism to genetic disorders or sensory deficits;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-7q6cqg	Fish oil consumption and its effect on inflammation in patients with leukaemia and lymphomas undergoing chemotherapy	Recruitment completed	Intervention	2015-08-17	<NULL>	<NULL>	585	Oral supplementation with fish oil and the effects on cytokine concentration and Proportion of T cell subsets in peripheral blood of patients with hematological neoplasms undergoing chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7q6cqg	<NULL>	Aged 16 years old or more; present hematologic malignancy diagnosis, be able to start chemotherapy; present adequate oral intake conditions; accept to participate of anthropometric and biochemical evaluations, indicating your acceptance by signing the Free and Clarified Consent Term. Additionally, individuals under the age of 18,will be included in the study only after signed parental consent.	Aged less than 16 years old, no legal parental consent if under 18 years old, to be in palliative care; receiving statins and/or some nonsteroidal anti-inflammatory drug; possess any infectious disease diagnosis, be allergic to fish and/or derivatives, have made use of fish oil and/or other supplements containing omega-3 six months before the beginning of the study or being pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9crpzc	Effects of active computer gaming  and aerobic exercise on memory, attention and physical performance in older adults	Recruitment completed	Intervention	2015-08-17	<NULL>	<NULL>	586	Cognitive performance in older adults: eletronic games, physical activity and nutrition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Santa Catarina	Centro de Deportos da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9crpzc	<NULL>	"Individuals of both sexes (target sample = 27 subjects); aged 55 years or older;  not participating in regular exercise programs in the last three months;
who provide a medical certificate that indicates the consent to participate in physical exercise; subjects without contact videogames of games and exergames; people without visual and hearing impairment, which may hinder the identification of colors, images and sounds."	Diagnosis of Alzheimer&apos;s disease; Parkinson&apos;s disease; disabling neurological diseases; psychiatric comorbidities; neurodegenerative diseases; severe cardiovascular disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2kpz5j	Analysis of microorganisms existing in denture wearers before and after the use of two adhesives	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	587	Oral microbiota analysis of conventional complete dentures wearers before and after the use of two adhesives	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista - UNESP	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2kpz5j	<NULL>	Adult individuals; receptive and mentally agile; good understanding of spoken Portuguese; with availability to attend evaluations during the experimental phase; alveolar ridges with normal resilience and volume	Systemic debilitations; use of antibiotics at the moment of inclusion in the study and for 3 months prior to the first assessment or sample collection; previous use of denture adhesives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9msy3t	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	588	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9msy3t	<NULL>	Sixty athletes that run during their training; the run training occurs at least three times a week; presence of the medial tibial stress syndrome induced by sports practice for at least six weeks and pain on palpation in the distal posteromedial border of the tibia.	Suspicion of tibial stress fracture or compartment syndrome; history of surgery in lower limbs or tibia fracture; paresthesia; other conditions that cause pain in the leg or presence concurrent pain; such as pain in the knee or ankle sprains.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-5x69x2	Action of Acupuncture on the ear to reduce pain in muscles and bones	Recruiting	Intervention	2015-08-17	<NULL>	<NULL>	589	Contribution of Auricular Acupuncture for reduction chronic musculoskeletal pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-15	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5x69x2	<NULL>	Size of Target Sample: 200. Age (18 years or more); orientation in time; place and person; report the presence of chronic pain (existing for six months or more); score more than four on the Numerical Pain Intensity Scale; have availability of time for submission to auricular acupuncture sessions.	Have infection; inflammation or injury to the ear; make use of piercing (except ordinary earring); people who have allergies to metal or micropore; those who use other energy therapies (massage; herbal medicine; reiki; flower therapy); physical therapy in period of auricular acupuncture; make continued use of medication for pain relief; do not answer three tries against to the researcher; refuse to receive the headset processing with needles and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8h32gy	Effect of intensity of electric current and evidence of blinding method	Data analysis completed	Intervention	2015-08-17	<NULL>	<NULL>	590	Effect of intensity of interferential current and validation of the placebo method	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-15	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8h32gy	<NULL>	Healthy subjects; 18 to 60 years of age.	Participants with peripheral nerve injury in the upper limbs; presence of pain in the upper limbs; pregnancy; chronic diseases; use of cardiac pacemaker; epilepsy; allergy to the material of the electrodes; current use of analgesic medication or in the last seven days; altered skin conditions or loss of sensation in the established areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-3j6rdg	Intravenous infusion of a single solution with with midazolam and fentanyl versus intravenous infusion of midazolam and fentanyl in separate solutions	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	591	Intravenous infusion of  a combined solution of midazolam and fentanyl solution vs separated midazolam and fentanyl	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-01-01	Hospital do Servidor Público Municipal	Hospital do Servidor Público Municipal	https://ensaiosclinicos.gov.br/rg/RBR-3j6rdg	<NULL>	A total of 40 consecutive patients will be included; aged between 1 month and 16 years and requiring mechanical ventilation; with an expected mechanical ventilation duration of at least 48 h and requiring sedative/analgesic drugs infusion.	Patients under 1 month old; patients over 16 years old; presenting severe neurological injury or central nervous system impairment that could affect the assessment of the sedation level. Also; patients will be excluded if they receive any neuromuscular blocking agent or another sedative drug (e.g.; ketamine; dexmedetomedine; clonidine; thiopental; thionembutal; chloral hydrate) during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6cf4xh	A preliminary study for testing a new drug to kidney stones treatment	Not yet recruiting	Intervention	2015-08-18	<NULL>	<NULL>	592	A Phase I/II clinical trial for evaluating safety and efficacy of an innovative medicine to nephrolithiasis treatment	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2016-01-04	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Apis Flora industrial e comercial limitada	https://ensaiosclinicos.gov.br/rg/RBR-6cf4xh	<NULL>	18 to 55 years old; male; any race, healthy volunteers; non-smoking; without drug addiction, use of alcohol or medicines.	Female; elderly (age&gt;55years); any clinically detectable disease, found on clinical history or physical examination; abnormal ECG (except unspecific ventricular repolarization changes, sinus brady/tachycardia); abnormal laboratory tests in blood cells count, kidney, reproductive, metabolic or hepatic function; participation in clinical trials in the last year; history of allergic reaction to medicines; use of any drug one week before the beginning or during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8jtkww	The effect of muscle strengthening in children with cerebral palsy	Recruiting	Intervention	2015-08-18	<NULL>	<NULL>	593	The effect of strengthening exercises on the functional aspects and patterns of muscle recruitment in children with cerebral palsy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-06	Universidade Federal de Uberlândia	Hospital e Centro de reabilitação da Associação de Assistência a Criança Deficiênte	https://ensaiosclinicos.gov.br/rg/RBR-8jtkww	<NULL>	Children with cerebral palsy, that are in treatment of rehabilitation at Association Assistance for Disable Child (AACD)in the city of Uberlândia-MG, who have between six to fifteen years old, whose parents or guardians have signed consent forms; that present motor level I, II, III do Gross Motor Function Classification System (GMFCS) and that present to perform cognitive tasks Gross Motor Function Measure (GMFM)and that did not undergo into medical procedures (botulinum toxin and surgery) for six months and have no deformities or pain	Children with clinical instability, such as seizures or who require frequent hospitalizations or those who have pain and deformity or those who have three absences in a month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-2hxj58	Effect of physical therapy in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2015-08-18	<NULL>	<NULL>	594	Effects of different physical therapy protocols on knee osteoarthritis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-12	UNESP - Faculdade de Medicina de Botucatu	FAI - Faculdades Adamantinenses Integradas	https://ensaiosclinicos.gov.br/rg/RBR-2hxj58	<NULL>	Aged 60 and over; both sexes; diagnosis of OA in one knee and the functional class I, II and III according to clinical and radiographic criteria of the American College of Rheumatology	Associated disease that primarily affects the lower limbs (ankylosing spondylitis; rheumatoid arthritis; neurological diseases); surgical history on his knees in the last year; physical therapy the past six weeks; contraindications to the aquatic and terrestrial service; osteoarthritis functional class IV according to clinical and radiographic criteria of the American College of Rheumatology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6s67w4	"Pediatric Arthritis Study of Certolizumab
Pegol (PASCAL)"	Recruitment completed	Intervention	2015-04-14	<NULL>	<NULL>	595	"A multicenter, open-label study to assess the pharmacokinetics, safety and efficacy of Certolizumab pegol in children and adolescents with moderately to severely active polyarticular-course Juvenile
Idiopathic Arthritis (JIA)"	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2012-03-08	UCB BIOSCIENCES GmbH	UCB BIOSCIENCES GmbH	https://ensaiosclinicos.gov.br/rg/RBR-6s67w4	<NULL>	Subjects must have had polyarticular juvenile idiopathic arthritis (JIA) for at least 6 months prior to baseline (polyarticular JIA is defined as more than or equal to 5 joints with active arthritis, including: polyarthritis rheumatoid factor positive, polyarthritis rheumatoid factor negative, extended oligoarthritis, psoriatic arthritis, juvenile arthritis and enthesitis-related arthritis (ERA)). The study population will consist of 2-17 year-old subjects in the inclusion with a minimum weight of 10 kg. Subjects must have had an inadequate response or intolerance to at least one disease modifying anti-rheumatic drug (DMARD). Methotrexate (MTX) and oral corticosteroids will be allowed at stable doses prior to Screening. If not using Methotrexate, subjects must have had an inadequate response or intolerance to Methotrexate (MTX).	Subjects with a history of systemic juvenile idiopathic arthritis (JIA), with or without systemic features. Subjects have active uveitis or a history of active uveitis within preceding 6 months to baseline. Known history of Tuberculosis (TB), or high risk of acquiring TB and latent TB infection; chronic, recurrent infection current sign or symptom which may indicate infection, or at high risk of infection. Viral Hepatitis or Human Immunodeficiency Virus (HIV) infection; live vaccination, including attenuated, within defined period prior to study entry or during the study (non-live vaccinations are permitted at any time prior to and during the study). The use of, or dose changes to, specific medications (eg, non-biologic DMARDs, biologic DMARDs, oral and intramuscular/intravenous/intra-articular Corticosteroids) will not be allowed for defined periods of time prior to study entry. Previous exposure to Certolizumab Pegol (CZP), to more than 2 biologic DMARDs and previous lack of response to more than 1 Tumor Necrosis Factor (TNFalpha)antagonist drug.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-2c3c52	Simplified dental restorations in patients undergoing  Blood Cancer treatment	Recruitment completed	Intervention	2015-08-19	<NULL>	<NULL>	596	Conservative treatment in patients with special needs	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-04	Faculdade de Ciências da Saúde - Universidade de Brasília	Faculdade de Ciências da Saúde - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2c3c52	<NULL>	Patients between 04 to 12 years-old; patients whose parent or legal guardian authorizing the investigation; patients who did not present severe systemic involvement, that prevented clinical examination and dental procedures; patients in onco-hematologic therapy in HGPP (Palmas General Public Hospital) hospitalized or who are at beds home.	Patients whose parents or guardians did not consent to this investigation; patients outside the specified age (02 to 13 years); patients whose systemic involvement would prevent the realization of conservative technique under study; patients in the multidisciplinary team don&apos;t aprove the manipulation of the oral cavity; patients who moved Palmas or which precluded evaluation of restorations; patients whose teeth showed clinically pulp exposure or abscess.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-55f97c	B12 Effect of supplementation and pulmonary rehabilitation in aerobic performance in patients with chronic obstructive pulmonary disease: a randomized study	Recruiting	Intervention	2015-07-14	<NULL>	<NULL>	597	Eight-week effect of physical training with vitamin B12 supplementation on functional capacity in patients with Chronic Obstructive Pulmonary Disease (COPD )	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-55f97c	<NULL>	Volunteers with chronic obstructive pulmonary disease stages III and IV of the GOLD second disease; both sexes ; aged between 40 and 80 years ; at least four weeks free of disease exacerbation ; former smokers ; Current diagnosis or without other cardiopulmonary conditions such as asthma , interstitial lung disease , pulmonary hypertension , cardiac insufficiency or arthropathy , which does not allow exercise tests .	"Volunteers with Chronic Obstructive Pulmonary Disease stages I and II of the disease according to GOLD criteria; participating in any program
cardiopulmonary rehabilitation ; which show no ability to perform pulmonary function tests, gradual or exhaustive effort load
constant; Volunteers with heart disease, dilated bronchi , rheumatic diseases , physical deformities that prevent the achievement of exercise or
that are not available to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6wvpjq	Effects of substances used after dental bleaching	Data analysis completed	Intervention	2015-08-07	<NULL>	<NULL>	598	In situ and in vivo study of bioactive agents effects on bleached enamel	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-04	Faculdade de odontologia da Universidade Federal do Pará	Faculdade de odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6wvpjq	<NULL>	60 people aged between 18 and 26 years; any genders; good health; non-smoking; pH and salivary flow within normal limits; healthy  teeth and initial color A2 or darker according to the Vita scale.	Having received previous dental bleaching ; restorations on the anterior teeth; pregnant or nursing women; having teeth darkened by tetracycline, fluorosis or endodontic treatment; patients with teeth grinding; having non-carious cervical lesion; and dentin hypersensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-32vkkr	Inspiratory muscle training in intensive care unit patients.	Recruiting	Intervention	2015-08-27	<NULL>	<NULL>	599	Ventilatory weaning in intensive care unit (ICU): evaluation of maximum inspiratory pressures and inspiratory muscle training with powerbreathe®.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-16	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-32vkkr	<NULL>	Adequate gas exchange as indicated by a PaO2 above 60 mmHg while breathing with an FIO2 of 0.50 or less; hemodynamically stable for 24 hours prior to participation or requiring only minimal intravenous pressor agents (dobutamine or dopamine less than 5mcg/kg/min, phenylephrine less than 1 mcg/kg/min); be able to follow simple verbal directions related to inspiratory muscle strength testing and training; receiving assist control or SIMV (synchronized intermittent mandatory ventilation) or pressure support ventilation via a tracheostomy, pressure support ventilation less than 15 cmH2O and PEEP (positive end expiratory pressure) less than 10 cmH2O. Unable to sustain unsupported breathing for at least 24 consecutive hours following resolution of factor(s) precipitating respiratory failure.	Inadequate gas exchange as indicated by a PaO2 under 60 mmHg while breathing with 0.50 or less percentage of oxigen; be medically instable and unready to be weaned from the ventilator as determined by the attending physician; hemodynamically instable for 24 hours requiring intravenous pressor agents (dobutamine or dopamine upper than 5mcg/kg/min, phenyleprine  upper than 1mcg/kg/min); receiving continuous sedation and mechanical ventilation; have any progressive neuromuscular disease such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis, or other neuromuscular disorder that would interfere with responding to inspiratory muscle training; have an anticipated life expectancy under 12 months; have a core temperature  above 38.5°C; have a spinal cord injury above T8 and any skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs; using any type of home mechanical ventilation support prior to hospitalization; body mass index upper than 40 kg/m2; require continuous sedative or analgesic agents that will depress respiratory drive or the ability to follow commands; excessive secretions (requiring suctioning more than once every hour).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-5q24zh	Effect of Aerobic Training on Blood Pressure Levels of Hypertensive Subjects	Recruiting	Intervention	2015-08-28	<NULL>	<NULL>	600	Effects of Aerobic High Intensity Training on Blood Pressure Levels of Resistant Hypertensive	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Laboratório de Estudos do Treinamento Físico Aplicado à Saúde	Programa Associado de Pós-Graduação em Educação Física UPE/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-5q24zh	<NULL>	Age between 40 and 60 years; men or women; body mass index under 30 kg / m²; able to participate in exercise; no regular physically active in the last 4 months	Smoking; with history of ischemic stroke or hemorrhagic; or CHD; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-46zqr8	Catheter use evaluation in peripheral vein	Recruitment completed	Intervention	2015-08-28	<NULL>	<NULL>	601	Effectiveness of peripheral venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-04	Universidade Federal do Paraná - UFPR	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-46zqr8	<NULL>	Age between 18 and 100 years; both sexes; admitted to clinics / and / or surgical units searched the hospital; obtain peripheral venous access in the upper limbs, in gauges 20 and / or 22 gauges; prior authorization or first degree relative to participate in the study prior to venipuncture, by signing the Informed Consent and Informed.	Present fragility of peripheral venous network that prevents the puncture peripheral catheter; allergic reaction known to the material of catheters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8wtq2b	Impact of macrolides antibiotics in mortality of patients infected by HIV with community-acquired pneumonia.	Recruitment completed	Intervention	2015-08-28	<NULL>	<NULL>	602	Impact of macrolides in mortality of patients infected by HIV with pneumonia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-13	Instituto de Infectologia Emílio Ribas	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8wtq2b	<NULL>	"Age over 18 years; HIV infection and community acquired pneumonia.
Calculated sample: 228."	Patients with hospitalization for two or more days in the 90 days prior to admission; coming from nursing homes or shelters; if they had health care in those sites; patients that had received intravenous antibiotics; chemotherapy or treatment of bedsores in the last 30 days; in dialysis; with another cause that justifies the lung symptoms on admission; such as pulmonary fibrosis; pneumocystosis; tuberculosis or other non-bacterial disease; pregnant or nursing women; patients allergic to the study medications (ceftriaxone and azithromycin) or patients that had already been randomized in this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-283zts	Haemodynamic effects of manual hyperinflation associated to PEEP in patients with septic shock	Data analysis completed	Intervention	2015-08-13	<NULL>	<NULL>	603	Haemodynamic effects of manual hyperinflation associated to PEEP in patients with septic shock	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Hospital São Lucas da Pontificia Universidade Catolica do Rio Grande Do Sul	Hospital São Lucas da Pontificia Universidade Catolica do Rio Grande Do Sul	https://ensaiosclinicos.gov.br/rg/RBR-283zts	<NULL>	32 adult patients were included with septic shock who require the deployment catheter pulmonary artery; which signed the informed consent form and do not present any exclusion criteria.	Patients under the age of 18 years or over 80 years; pregnancy; acute myocardial infarction 3 months before the study; septic shock secondary to pulmonary disease; severe heart disease; with fractions of less than 30% ejection; and expectancy of less than 24 hours life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-4k7rm6	Pulse oximetry during dental treatment in people with sickle cell disease	Recruiting	Intervention	2015-08-28	<NULL>	<NULL>	604	Pulse oximetry during dental treatment in people with Sickle Cell Disease	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-26	Universidade Federal do Rio de Janeiro -UFRJ	Universidade Federal do Rio de Janeiro -UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-4k7rm6	<NULL>	Sixty six teens (from 12 years old) or adults (to 50 years old) with diagnosis and genotype for sickle cell disease established by blood test and medical clearance for dental treatment. Teens or adults with SCD who agree and sign the free and informed consent.Teens or adults with SCD and cognitive ability to answer the questionnaires. Teens or adults with SCD and adequate cognitive comportment whose laboratory and biochemical parameters enable the dental treatment.	"Pregnancy, syndromes or any other condition that requires for care for people with special needs.Adolescents and adults with Sickle Cell Disease who received blood transfusions within 30 days;
Teens or adults with Sickle Cell Disease and heart or lung disease. Teens or adults with Sickle Cell Disease and adenoidal or tonsillar obstruction. Teens or adults with Sickle Cell Disease and serology HIV positive. Teens or adults with Sickle Cell Disease and positive serology for viral hepatitis.Teens or adults with Sickle Cell Disease and hypertension.Teens or adults with Sickle Cell Disease undergoing hormone therapy. Lack of follow-up consultations by adolescents or adults with Sickle Cell Disease during the stages research.Teens or adults with Sickle Cell Disease in whom we could not use the pulse oximeter or reading the oximeter was inconsistent. Teens or adults with Sickle Cell Disease who have not responded the questionnaire on fear / anxiety during dental treatment. Teens or adults with Sickle Cell Disease who decline the survey, retirarando their terms of appointment or consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8wn8ck	Intervention by phone with patients and families in radiotherapy	Recruitment completed	Intervention	2015-08-31	<NULL>	<NULL>	605	Intervention by phone: strategy for managent of anxiety and patientes family treatment in radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de Santa Maria/ Pró-Reitoria de Pós-Graduação	CNPq - Conselho Nacional de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-8wn8ck	<NULL>	patient: age less than 18 years, both sexes, have handset available with signal capture. Family: age less than 18 years; both sexes; be present with the patient in the first nursing consultation in the radiotherapy clinic. The population of study will be composed to 90 persons in the interventional group and 90 persons in the control group.	Patient: absence of medical conditions, cognitive and / or communication. Family: lack of health conditions, cognitive and/or communication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-39bjm4	The effect of atorvastatin plus aspirin compared with a non-therapeutic substance on the function of the blood vessels and inflammation in HIV patients under treatment presenting a low risk of cardiovascular disease.	Recruiting	Intervention	2015-09-01	<NULL>	<NULL>	606	The effect of atorvastatin plus aspirin versus placebo on the  endothelial function and inflammation in HIV patients under antiretroviral treatment presenting a low risk of cardiovascular risk. A randomized and double blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-27	Hospital das Clínicas da Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-39bjm4	<NULL>	HIV patients on antiretroviral use ; both genders , aged between 18 and 60; lower cardiovascular risk than 10 % probability of occurrence of cardiovascular events in 10 years , as measured by the Framingham risk score .	history of hospitalization and  opportunistic infections in the past 90 days; history of chronic liver dysfunction, thyroid dysfunction, autoimmune disease, history of hepatitis B or C; pregnancy or breastfeeding; previous use of statins, fibrates, ezetemibe, omega 3 , aspirin, NSAIDs, oral anticoagulants, interferon, interleukins, growth hormones, immunoglobulins, glucocorticoids or other immunosuppressants; alcohol abuse; previous intolerance to statins and  aspirin; hemophilia; AST and ALT greater or equal 120 IU / L; CPK grater ou equal 167 U / L; muscle trauma or recent surgery performed until four months earlier; history of cardiovascular disease, diabetes, cancer and renal dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8cq282	Use of Gastrin-Releasing Peptide in Children with Autism Diagnosis	Data analysis completed	Intervention	2015-09-08	<NULL>	<NULL>	607	"Use of Gastrin-Releasing Peptide in Pediatric Subjects with diagnosis of Autism.
Study of cross-over, randomized, placebo-controlled, proof of concept for the evaluation of safety, tolerability and efficacy"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Programa de Pós-Graduação em Saúde da Criança e Adolescente - Universidade Federal do Rio Grande do Sul	Rudimar dos Santos Riesgo	https://ensaiosclinicos.gov.br/rg/RBR-8cq282	<NULL>	Autism Diagnostic according to DSM-5 criteria, as confirmed by the investigator&apos;s judgment; Age between 3 and 9 years; Normal Neuroimaging (computed tomography or magnetic resonance imaging of the skull); Normal Genetic research (karyotype for girls; karyotyping and Fragile X research for boys); Subjects of use of psychopharmacological treatment considered appropriate by the investigator on a stable dose for at least 4 weeks before inclusion, without adjustment of the dose throughout the study;	History of diabetes mellitus; Secondary autism presence or diseases with features common to autism, as follows: diagnosis of fragile X syndrome, Rett syndrome, Angelman syndrome, Prader-Willi syndrome and Smith-Lemli-Opitz syndrome, Tuberous Sclerosis; Be carrier of any condition associated with increased acid secretion in the gastrointestinal system (gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis); History of heart disease; Any guy whose basic medication require dose adjustment or interruption; Any condition that, in the opinion of the investigator, would put the security of the individual at risk after exposure to the test substance; Reside outside the city of Porto Alegre and the metropolitan area; Parents or guardians refuse to sign the free and informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-85bbp4	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® pre puberty in children with failure to thrive due to deficiency of growth hormone.	Not yet recruiting	Intervention	2015-09-09	<NULL>	<NULL>	608	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® in prepubertal children with growth deficiency due to deficiency of growth hormone.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2015-10-01	ICF - Instituto de Ciências Farmaceuticas de Estudos e Pesquisas LTDA	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-85bbp4	<NULL>	Children aged 4 years and 13 years (for girls) and 14 years (for boys); Children prepubertal (Tanner stage 1); Bone age less than 11 years (for boys) and 9 years (for girls), documented by radiographs of the hand and wrist (will accept a radiograph performed within 6 months prior to enrollment in the study); Naïve children with growth hormone; Children diagnosed with disturbance in growth due to deficiency of growth hormone documented before initial treatment with r-hGH through: The height z score &lt;-2.0 SD for age and sex; A response to a test stimulus GH release with peak blood 7 ng / ml in the presence of abnormalities morphostructural hypothalamic-pituitary region shown by Nuclear Magnetic Resonance (NMR) or; response to stimulus two tests of GH release with peak  7 ng / ml in the presence of a normal NMR (stimulating agents are acceptable insulin, clonidine, glucagon, arginine and L-dopa). Historical values of GH in blood up to 12 months prior to enrollment in the study will be acceptable. An MRI performed up to 2 years before inclusion in the study is acceptable; History of growth velocity below the mean for the normal population for at least 6 months prior to inclusion in the study, according to the table of VC Tanner (must be historical height data with a minimum of 6 months and maximum of 18 months. Researcher must ensure that the measurements were performed in a standardized way in standard stadiometer (rigid deck and rigid ruler); Baseline IGF-I -0.5 SD for age and sex (results provided by the central laboratory).	"Children aged &lt;4 years; Children with clinical signs of puberty (breast / genitalia and pubic hair Tanner stage 2); Note: Children who enter puberty during treatment (breast development Tanner 2 / or testicles 4 ml or 2.5 cm in greatest diameter) shall be excluded; Other causes of disorder in children including growth in stature for gestational age (SGA), Turner syndrome, Prader-Willi syndrome, other causes; Children with closed epiphyses bone; Children with physical changes that prevent accurate measurement of height; Children with comorbidities that prevent normal growth. Patients with central hypothyroidism may be included, if well controlled with l-thyroxine, evidenced by normal free T4 dosages; dysmorphic syndrome; Presence of signs of skeletal dysplasia; Evidence of active malignancy or with less than two years of treatment considered curative; uncontrolled growth of benign intracranial tumors; Children with benign intracranial hypertension; Children with clinical evidence of malnutrition considered relevant to the discretion of the investigator; Children with Diabetes mellitus type 1 or 2; severe acute disease, including complications after heart surgery by thoracotomy, abdominal surgery, multiple accidental trauma or acute respiratory failure; concomitant chronic disease which may interfere with the analysis of the study (eg, hyperthyroidism / uncontrolled hypothyroidism, gastrointestinal diseases, cardio-respiratory diseases, liver failure, kidney failure, bone pathologies that can affect the growth, chronic inflammatory diseases and inborn errors of metabolism); Patients with hormone deficiency related diseases by panhypopituitarism may be included if properly controlled; MRI findings that may interfere with the study drug (examples: intracranial hypertension, tumors in the hypothalamic-pituitary region); Children with anti-GH antibodies;
Children undergoing treatment for the disorder or attention deficit hyperactivity disorder deficit hyperactivity disorder; Concomitant medication that could influence the secretion of growth (eg, estrogen, androgen, anabolic steroids, steroids, aromatase inhibitors) hormone. Physiological doses of corticosteroids for the treatment of pituitary deficiency are allowed as well as low-dose inhaled and / or nasal steroids for the treatment of asthma or chronic rhinitis (500mcg or less / day beclomethasone or equivalent); or known allergy to the study medications, or any of the excipients or thinner / solvent hypersensitivity; Participation in another clinical study within 3 months before study entry; Statement of legal limitation disability or parent / legal representative"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-4tkh6s	Translation of the S.W.I.M. scale	Recruitment completed	Intervention	2015-09-11	<NULL>	<NULL>	609	Translation, cultural adaptation and reliability of the s.w.i.m. scale	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4tkh6s	<NULL>	Professionals with degree in physical therapy specializing in aquatic therapy; professionals with a degree in physical education with experience in the swimming adapted area; both genders; aged 21 to 60 years. Healthy children; both genders; aged 3 to 11 years; children who underwent even months of swimming lesson.	Professionals who not have experience and formation in physiotherapy and physical education. Children under 3 years old and over 11 years; children with motor deficit or learning change; children over 6 months of swimming lessons; children with changes in health status; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-74s6yx	Evaluation of Oral Supplementation With Fish Oil Nutritional Status, Immunity and Inflammation of Patients With Stomach Cancer	Recruiting	Intervention	2015-09-14	<NULL>	<NULL>	610	Impact of Oral supplementation with omega-3 in the Nutritional Status, Immune and Inflammatory Profile of Patients with Gastric Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-20	Instituto Nacional de Câncer	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-74s6yx	<NULL>	"Target sample size is 106 patients.
Patients with gastric cancer. 
Patients in pre-treatment (chemo / radiation / surgery). 
Female or male patients aged between 20 and 65 years. 
Signing of the Informed Consent."	"Patients with Chronic Hepatic Insufficiency  (CHILD-PUGH C); With HIV Virus or Acquired Immune Deficiency Syndrome (AIDS); Congestive Heart Failure Record; Chronic Kidney Disease; Diabetes Mellitus.
Patients undergoing chemotherapy or radiotherapy already started.
Patients with other cancer diagnosis in up to five years ago.
Patients with focal infection or inflammatory disease.
Patients who refuse to sign the consent form for study participation.
Patients who did not tolerate the use of nutritional supplementation or do not use the supplement as prescribed amount i.e. adhesion to the lower supplementation to 80% prescribed amount."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-7rd86h	The effect of elastic and adhesive bandage on labor pain relief	Recruiting	Intervention	2015-05-07	<NULL>	<NULL>	611	Kinesio Taping® on labor pain relief: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-12	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7rd86h	<NULL>	Labouring women with single fetus in vertex position and with good vitality; gestational age from 37 and 42 weeks; spontaneous onset of labor; cervical dilation from 3 to 5 cm; present at least two contractions in 10 minutes interval.	Hospitalization for cesarean sections; preeclampsia; diabetes I, II or gestational; heart disease; hypertension; kidney disease; epilepsy; psychiatric disorders; drug users; previous uterine scar; fetal death; fetal malformation; dermatitis or any infection in the banding application site; known allergy to the material of the bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-5n3mtj	Effects of laser therapy on the masseter of children with spastic cerebral palsy	Recruiting	Intervention	2015-09-14	<NULL>	<NULL>	612	Effects of photobiomodulation on the masseter of children with spastic cerebral palsy	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Cruzeiro do Sul	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5n3mtj	<NULL>	"Cerebral palsy diagnosis of spastic type;
with or without complaints of pain mouth opening; 
difficulty in performing oral hygiene;
utensils locking used for food or for oral hygiene;
trauma story in oral tissues"	Patients diagnosed with cerebral palsy spastic type associated with syndromes or other disabling condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-93ykhs	Behavioral and educational intervention: effects on return visit rates to receive the results of the Pap smear	Data analysis completed	Intervention	2015-09-15	<NULL>	<NULL>	613	Behavioral and educational intervention: effects on adherence of women to return visit to receive the results of the Pap smear	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-01	Universidade Federal do Ceará	Centro de Saúde da Família Aída Santos e Silva	https://ensaiosclinicos.gov.br/rg/RBR-93ykhs	<NULL>	"The size of the target shows: 775 women.
The sample selection followed the following eligibility criteria: have initiated sexual activity and perform the Pap smear in the data collection period. Minimum age: 18 years and maximum: 80 years."	As defined exclusion criteria were: present cognitive limitations that prevent them from answering the questionnaire, to participate in educational or behavioral intervention; and we have not done for any reason, cytologic collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-6xsy5t	Effect of the chiropractic and multidisciplinary treatment in the quality of life, functionality and pain in patients with spinal cord injury	Recruitment completed	Intervention	2015-09-16	<NULL>	<NULL>	614	Effect of the chiropractic and multidisciplinary approach in the quality of life, functionality and pain in patients with spinal cord injury	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Eduardo Linden Junior	Universidade Feevale	https://ensaiosclinicos.gov.br/rg/RBR-6xsy5t	<NULL>	Subjects between 18 and 60 years, with vision and hearing preserved, diagnosed with spinal cord injury who accept participate in the study by completing the Statement of Consent.	Do not fulfill the indicated program and do not sign the Statement of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-4ymcyc	Effect of hydroxyapatite paste on human enamel	Recruitment completed	Intervention	2015-09-16	<NULL>	<NULL>	615	In vitro and in situ effects of nano hydroxyapatite in bleached enamel with hydrogen peroxide	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-03	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4ymcyc	<NULL>	3 persons aged between 20 and 22 years; Height of the clinical crown of the upper molars above 5 mm; absence of cavities; absence of periodontal disease; normal oral pH around 7.0; normal salivary flow.	Patients with dentin sensitivity; gastroesophageal disturbances; pregnant or nursing women; patients with fixed prostheses or removable orthodontic appliances; drug users or smokers; and practitioners of water sports.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-9py4kd	Use of misoprostol before hyteroscopy exam to evaluate intrauterine in postmenopausal women.	Not yet recruiting	Intervention	2015-09-17	<NULL>	<NULL>	616	Use of misoprostol prior to hysteroscopy in postmenopausal women: a randomised, placebo-controlled clinical trial.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-9py4kd	<NULL>	182 Menopausal women with minimum age of 50 and maximum of 80 referred for endometrial assessment by hysteroscopy.	"Women with lower genital tract infection.
Women who have had intrauterine diseases that were previously treated by endoscopy.
Women who have never had sexual relations; with uterine malformation; with mental disabilities or undergoing pelvic radiotherapy.Women who refused to participate in the study.Women who had metrorrhagia during the exam."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-3tykzt	Effects of continuous aerobic and interval exercise in patientes with heart failure	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	617	Effects of continuos aerobic and interval trainin in function cardiopulmonary in patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3tykzt	<NULL>	Cardiologist forward with diagnosis confirmed by clinical and complementary test (echocardiogram); Patient with Functional Class I, II and III HF according to the New York Heart Association (NYHA); 20 ejection fraction to 53% by echocardiography detects the last 6 months; Both genders; Clinical stability; Heart Failure compensated; Spirometry with FEV1 / FVC&gt; 80%; Cardiac pacemaker absence. In addition, patients may not perform training or physical activity elsewhere.	Decompensated heart failure development; CPET or arrhythmias during exercise identified by clinical and / or ECG changes; unstable angina; embolism; acute systemic infection; Lock 3rd degree AV (without pacemaker); pericarditis or acute myocarditis; uncontrolled arrhythmias; ST-segment depression&gt; 2 mm during the year; HF with normal systolic function (ejection fraction&gt; 53%); Class D (red) in the stratification of risk for adverse cardiac events while performing physical exercise; uncontrolled diabetes mellitus; Myocardial Revascularization need for surgical or other procedure; lack of understanding of the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-54mj4m	Brazilian music effect on heart rate variability in overweight and obese subjects	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	618	Influence of Brazilian music in the variability of the heart rate of overweight / obesity: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-31	Universidade Presbiteriana Mackenzie	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-54mj4m	<NULL>	"Inclusion criteria: healthy volunteers; male gender; aged between 18 and 35 years; body mass index (BMI) above 24.9 kg / m2. This sample was chosen by recognized experience an increased sympathetic activity.
Individuals will be recruited from advertisements carried in the Mackenzie University and Federal University of Sergipe ."	Exclusion criteria: female gender; volunteers in use of cardiac pacemaker fixed frequency; diagnosis of chronic arrhythmias. Discontinuity criteria: subjects presenting instability in record heartbeat; inability to stand still during the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-5y9yyc	Impact of upper limbs exercises protocol on gait of children with Cerebral Palsy	Data analysis completed	Intervention	2015-09-17	<NULL>	<NULL>	619	Impact of upper limbs exercises on gait of children with Cerebral Palsy: a pilot trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5y9yyc	<NULL>	Children with clinical follow-up at AACD; diagnosed with spastic diplegic cerebral palsy; age between 3 and 13 years old; using type of gait aid; classified  level III of GMFCS (Gross Motor Function Classification System); able to attend the institution twice times a week; with 5 subjects for each group (total of 15 subjects).	Patients with less than 6 months of orthopedic surgical procedure and less than 3 months of neuromuscular blocking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-98x6b5	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiovascular and metabolic benefits?	Data analysis completed	Intervention	2015-09-20	<NULL>	<NULL>	620	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiometabolic benefits?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-15	Faculdade de Saúde Pública, Universidade de São Paulo	Faculdade de Saúde Pública, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-98x6b5	<NULL>	"Both sexes, aged between 35 and 69 years
Body mass index  between 25 and 40 kg / m2 with at least one of the following criteria: triglycerides above 150 mg/dl; total cholesterol above 230 mg/dL or LDL-C above 100 mg/dl or plasma fasting glucose between 100 and 124 mg/dl."	live outside the city of São Paulo; pregnant women; patients with neurological problems or severe psychiatric diseases;  use of anti-obesity medication; individuals with cancer, communicable and rheumatic diseases, liver or kidney failure, thyroid dysfunction untreated; a change of more than 5% of body weight within the last six months;  performing some type of diet or modifications to the usual eating pattern.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-3dtzdb	Analysis of movement and muscle activity of the balance of strategies used by children with spastic cerebral palsy during the pediatric previous range test	Recruitment completed	Intervention	2015-09-21	<NULL>	<NULL>	621	Kinematic and electromyographic analysis of the equilibrium strategies used by children with spastic cerebral palsy in the pediatric reach test	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dtzdb	<NULL>	"The inclusion criteria for the CPG (Cerebral Palsy Group) will be the diagnosis of cerebral palsy; grade mild or moderate; diparesis type; grade I (without walking restrictions, limitations in the more advanced gross motor skills) and II (walk without assistive devices, with limitations in space open and community) according to the GMFCS (Gross Motor Function Classification System).
For CG (Control Group), the inclusion criteria established will be the absence of any motor; perceptual; sensory and cognitive commitment."	"Exclusion criteria for the CPG (Cerebral Palsy Group) will be considered the presence deformity in the lower limbs or spine that compromises stay in the upright posture and cognitive changes that undermine the understanding of the tasks performed during avaliação.
For the CG (Control Group), exclusion criteria will be the diagnose of any malformations; genetic syndromes; congenital defects; deformities
postural or other changes that may bring harm to the neuromotor; cognitive and emotional development of the child.
For both groups, be an exclusion criterion the presence of respiratory symptoms or respiratory disease with prior interval of one month of evaluation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-843tnq	Treatment of HIV/AIDS patients with Glutamine Dipeptide	Not yet recruiting	Intervention	2015-09-21	<NULL>	<NULL>	622	Impact of Glutamine Dipeptide Supplementation in HIV/AIDS patients treated with antiretroviral therapy.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	UEM-Universidade Estadual de Maringá	UEM-Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-843tnq	<NULL>	HIV positive; both genders; between 18 and 60 years; regular use of antiretroviral therapy; good adherence to therapy; HIV viral load stable in the last 6 months	pregnant women; psychiatric patients; more than 60 years old; chronic kidney disease;  swallowing difficulty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-8d26mf	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	Not yet recruiting	Intervention	2015-09-30	<NULL>	<NULL>	623	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Rio Grande do Sul	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8d26mf	<NULL>	Patients diagnosed with cystic fibrosis (n=40) confirmed by two tests dosage Na and Cl in the identification or sweat 2 mutations known to be related to illness and aged 6-18 years.	"Patients with advanced lung disease (FEV1 &lt; 40%); Patients using oral corticosteroids in the last two months and inability to
perform pulmonary function tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-964dgy	Effectiveness of physical activity counseling and referral schemes in the leisure time physical activity of an elderly cohort: a randomized controlled trial	Data analysis completed	Intervention	2015-09-30	<NULL>	<NULL>	624	Physical activity promotion programs for the elderly: from diagnosis to action - a proposal for the Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	https://ensaiosclinicos.gov.br/rg/RBR-964dgy	<NULL>	142 people aged over 60 who were part of EPIDOSO / UNIFESP Project were included; who answered the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009) and had no impediments to regular physical activity.	Have not performed the evaluation with the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009); have impediments to regular physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-6y2srf	Effects of physical exercise and recreational activities in the memory loss of Primary Health Care elderly users.	Recruiting	Intervention	2015-09-30	<NULL>	<NULL>	625	Effects of an aerobic, strength and cognitive training program on the mild cognitive decline of Public Primary Health Care elderly users in Porto Alegre	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-11	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-6y2srf	<NULL>	Both genders volunteers; aged 60 years and over; independent at activities of daily living; able to walk independently to the location of training and testing; mild cognitive impairment detected by the Addenbrooke Cognitive Examination (2007 revised version).	Severe psychiatric disorder or traumatic brain injury; use of acetylcholinesterase inhibitors; current substance abuse; important communication deficiencies; simultaneous participation in other research studies; regular practice of physical activity (at least once a week in the last three months); physical therapy treatment in the last three months; physical and functional limitations that might prevent the practice of physical activity; conditions that promote disabilities; visual deficits that prevent reading; recurrent vertigo; uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-2bm36r	Comparison of Cough Assist and Endotracheal Suctioning in airways hygiene of patients in mechanical ventilation	Data analysis completed	Intervention	2015-10-04	<NULL>	<NULL>	626	Comparison of Cough Asisst and Endotracheal Suctioning in bronchial hygiene of patients undergoing mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-17	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2bm36r	<NULL>	The sample consisted of 43 individuals. Inclusion criteria were patients of both sexes; 18 years; who were on mechanical ventilation for more than 48 hours; with no trauma face and hemodynamically stable.	Were defined as exclusion criteria: history of pulmonary emphysema; presence of barotrauma; thrombocytopenia and impossibility of applying some of the techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-97v6f5	Gingival assessment around the teeth in patients using partial dentures	Recruiting	Intervention	2015-10-08	<NULL>	<NULL>	627	Periodontal evaluation in removable partial dentures wearers	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-25	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-97v6f5	<NULL>	Minimum age 18 years. Both genders. Have been met and rehabilitated with maxillary denture and lower removable partial Kennedy Class I. Treated at the service of the Faculty of Dentistry of the Federal University of Rio Grande do Norte.	Over 80 years. Weakened state of health.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-45xmzj	Effect and tooth sensitivity caused by the use of hydrogen peroxide gel in at-home bleaching - clinical study.	Recruitment completed	Intervention	2015-10-09	<NULL>	<NULL>	628	Randomized clinical trial on the efficacy and tooth sensitivity of different concentrations of hydrogen peroxide.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-16	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-45xmzj	<NULL>	Patients older than 18 years; good oral and general health; free maxillary anterior teeth restorations and do not carious lesion present; have the color of A2 or darker teeth according to the color scale Classical Vita (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who already underwent tooth whitening; pregnant or lactating patients; who report tooth sensitivity; staining tetracycline; fluorosis or endodontics; with parafunctional habits, patients with dental prostheses; appliances orthodontic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4tdvt9	Early exercise in patients with artificial breathing	Data analysis completed	Intervention	2015-10-13	<NULL>	<NULL>	629	Early mobilization of critical patients in mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-12	Hospital de Clínicas de Porto Alegre - HCPA	Hospital de Clínicas de Porto Alegre - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-4tdvt9	<NULL>	Patients in invasive mechanical ventilation for 72 hours.	Neuromuscular disease; stroke; multiple sclerosis; amyotrophic lateral sclerosis; myasthenia gravis; Guillain Barré; extubated within 48 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-8spkx9	Pain reduction compared postoperative period with the use of morphine versus methadone during anesthesia in cardiac surgery.	Recruiting	Intervention	2015-10-13	<NULL>	<NULL>	630	Postoperative analgesia comparing the Methadone versus Morphine during anesthetic induction in cardiac surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sul de Santa Catarina	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-8spkx9	<NULL>	Volunteers undergoing cardiac surgery myocardial revascularization without cardiopulmonary bypass; Both genders; ASA (American Society of Anesthesiologist) III or IV;	Volunteers with a history of illicit drug use; allergy to morphine or methadone; post-operative intubation than 48 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-234nb5	Interdisciplinary intervention with motivational approach in adolescents with overweight and obese	Recruiting	Intervention	2015-06-10	<NULL>	<NULL>	631	Interdisciplinary intervention effectiveness on motivacional approach in lifestyle modification in teenager with overweight and obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-15	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-234nb5	<NULL>	Adolescents between 15 and 18 years with BMI at or above the 85th percentile.	Provide absolute contraindication for physical activity for musculoskeletal, neurological, vascular problems (intermittent claudication), lung and heart; presence of diagnosis of severe psychiatric disorders and / or presence of significant cognitive impairments;pregnant women; diagnosis of Diabetes mellitus type I.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-3dwp5r	Comparison of  lymphatic drainage and exercises for the arms on changes in lymphatic circulation after surgery for breast cancer	Recruitment completed	Intervention	2015-10-14	<NULL>	<NULL>	632	Comparison of Kinesiotherapy and manual lymphatic drainage in the lymphatic compensation postoperative breast cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-19	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3dwp5r	<NULL>	First surgery for invasive carcinoma of ipsilateral breast; Conducting radical mastectomy.	"Immediate breast reconstruction;  Bilateral surgery; Difference in circumference upper limb prior to surgery more than two centimeters; Motor impairment in the upper limb ipsilateral prior to surgery;  Infection prior ipsilateral upper limb prior to surgery; Realization of sentinel lymph node biopsy;  Radiotherapy prior to surgery;
 Inability to understand the exercises."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-3czhsf	Oral health and mastication in patients with Parkinson’s disease	Recruiting	Observational	2015-10-14	<NULL>	<NULL>	633	Oral health and chewing function in patients with Parkinson’s disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Estadual de Campinas - Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas - Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3czhsf	<NULL>	"Case group: volunteer with Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses.
Control group: volunteers without Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses."	"Case group: volunteers should not have neurodegenerative disease, except for Parkinson&apos;s disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition.
Control group: volunteers should not have Parkinson&apos;s disease or other neurodegenerative disease; they should not have neurological disorders in which parkinsonism comprises the clinical condition."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4j6xfx	Treatment of mouth articulation&apos;s dysfunction.	Recruitment completed	Intervention	2012-02-01	<NULL>	<NULL>	634	Effects of upper cervical spinal&apos;s manipulation on electromyographic activity os masticatory muscles, signs and symptons os temporomandibular disorders.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-06-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-4j6xfx	<NULL>	The subjects of both groups must have a diagnosis of TMD according to the DRC, axis I, accompanied by pain and / or fatigue in the muscles of mastication during functional activities for a minimum period of one year and maximum of five years, with body mass index (BMI) to 25 kg/m2.	Was excluded from the study women with any missing teeth (except third molars), open bite, crossbite, suffering from partial or complete dentures, orthodontic treatment and / or medication (analgesics, anti-inflammatories and muscle relaxants), those who received treatment with cervical spine manipulation in the past 6 months and those in physiotherapy. Also, was excluded women with systemic neuromuscular diseases, migraine, history of trauma to the face and / or ATM, joint dislocation and testing extension and rotation of the head, which assesses the flow of the vertebral artery and the Sharp-Purser , indicating upper cervical spinal instability positive.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-9jv27c	Effects of a treatment performed with elastic tubings on heart, capacity of exercise and  muscle strength in pulmonary disease	Recruiting	Intervention	2015-10-15	<NULL>	<NULL>	635	Effects of a Resistance Training performed with elastic tubings on cardiac autonomic modulation, cardiopulmonary functional capacity and peripheral muscle strength in Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-21	Universidade Federal de São Paulo	Universidade Estadual de São Paulo - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9jv27c	<NULL>	COPD diagnosis; absence of cardiovascular diseases; absence of neuromuscular or skeletal reported diseases; absence of contraindications or any impediment to completion of the experimental protocol	"Individuals who do not produce at least 95% of sinus beats in the time series of intervals between beats will be deleted 
consecutive heart used in the analysis of heart rate variability; individuals as you do not complete the protocol experimental and who present clinical instability during the treatent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-33gm3k	Study of the effect of inspiratory muscle training on endothelial function, autonomic control, exercise capacity of life in patients with pulmonary hypertension.	Recruiting	Intervention	2015-10-22	<NULL>	<NULL>	636	Study of the effect of inspiratory muscle training on endothelial function, autonomic control, exercise capacity of life in patients with pulmonary hypertension.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-03	Irmandade Santa Casa de Misericórdia de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-33gm3k	<NULL>	Target sample:32 patients. Patients with pulmonary hypertension confirmed by right heart catheterization; the patient must be over 18 years; patients belonging to group I of pulmonary hypertension; patient in  functional class II or III of world health organization; patients with specific drug treatment for pulmonary hypertension stable for at least three months; patients willing to complete the training; patients with inspiratory muscle strength less than 70% predicted.	Patients using oxygen; patients with significant musculoskeletal disorders, intermittent pain; cognitive or neurological deterioration; patients with psychiatric-psychological disorders that may interfere in the understanding of the protocol; patients with a history of moderate or severe chronic lung disease; patients with hemodynamic instability; unstable angina or uncontrolled cardiac arrhythmia; patients who were hospitalized in the last three months; patients who participated in supervised exercise programs in the past three months; patients with inspiratory muscle strength more than 70% predicted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-5zyh8n	Resistance exercise effects on function, balance and gait in children with cerebral palsy	Recruitment completed	Intervention	2015-10-22	<NULL>	<NULL>	637	Effect of a Protocol of Resistance Training in functional capacity, balance and gait in the children with Cerebral Palsy	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-22	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5zyh8n	<NULL>	Children with spastic cerebral palsy will be recruited from the registration NUTEP patients (N = 20). Inclusion criteria will be children with good cognition, GMFCS (Gross Motor Function Classification System) levels I to III, mean age 3-8 years.	Previous orthopedic surgery; botulinum toxin injection in the previous 6 months; cardiac, respiratory or psychological conditions that compromise the implementation of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4c2jy8	Identification of coping skills used by alcohol users who wish to stop using by telephone assistance	Data analysis completed	Intervention	2015-10-22	<NULL>	<NULL>	638	Identification of coping skills used by alcohol users in the withdrawal process in a telephone counseling service	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-01	Universidade Federal de Ciências da Saúde	Universidade Federal de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4c2jy8	<NULL>	"Alcohol users who used at least once in the past year with or without the licit or illicit drugs capable of understanding the reading of the survey instrument and who accept participate in the study after oral exposure of the free and informed consent (IC) .
Sample size target is 105 particpantes
Maximum age 90 years
Minimum age 18"	Individuals will be excluded who do not understand the questions; those who are high on drugs at the time of interview and those who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-9f3ctb	Clinical Study Toothpaste base Rosemary on Plaque and Saliva Bacterium	Recruitment completed	Intervention	2015-10-22	<NULL>	<NULL>	639	Clinical evaluation of the antimicrobial activity of the dentifrice the basis of Rosmarinus officinalis Linn extract. (rosemary) on the biofilm and saliva S. mutans	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2014-02-08	UFPE-Universidade Federal de Pernambuco	UFRPE-Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9f3ctb	<NULL>	"Healthy volunteers; both genders; aged 18 to 45 years; minimum of 20 healthy teeth in the mouth; without systemic diseases; without the use of drugs; healthy oral condition
Sample size : 110 patients"	Smoking volunteers; pregnant women; people with periodontal disease or decay; carriers of important systemic diseases; drug users; people with braces	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-54pbt6	Effects of taping in pain and function  of patients with knee arthrosis: a blind randomised clinical trial	Recruitment completed	Intervention	2015-10-22	<NULL>	<NULL>	640	Effectiveness of taping in pain and functional capacity of patients with knee osteoarthritis: a blind randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-13	Universidade Federal de São Paulo	AACD - Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-54pbt6	<NULL>	74 Adult patients (18 from 80 years) referred AACD - Lar Escola São Francisco diagnosed with moderate knee osteoarthritis and agree to participate in the study according to the term informed consent	Patients with rheumatic diseases associated; orthopedic surgery of the lower limbs; prior injections of steroids in the past six months; obesity (BMI&gt; 35);allergy to components of physiotherapy; those who underwent physiotherapy in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-54jrwd	Influence of taping in postural balance in elderly with history of falls	Recruitment completed	Intervention	2015-10-23	<NULL>	<NULL>	641	Influence of sensory information in postural balance in elderly with history of falls	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-15	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-54jrwd	<NULL>	"They will be assessed non-institutionalized elderly; Residents in the city of Marilia-SP; aged greater than or equal to 60 years and with a history of one or
more falls in the 12 months preceding the assessment. They will be included in elderly survey of independent walking ability and without the use
Marching aids; having cognitive ability assessed by the Mini-Mental State Examination (MMSE)"	"Seniors who presented sequelae of neuromusculoskeletal diseases; arthritis; uncorrected vision problems; postural hypotension and perform
continued use of sedative drugs; antidepressants and hypnotic are not included in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-2z28qv	Physiotherapy effects on quality of life of patients with swelling of the legs living in elephantiasis transmission area	Recruitment completed	Intervention	2015-10-27	<NULL>	<NULL>	642	"Effects of complex physical therapy and its influence on functional independence and
quality of life of lymphedema sufferers in lower members residing in
endemic area of lymphatic filariasis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-08	Centro de Pesquisas Aggeu Magalhães/ FIOCRUZ	Faculdade Estácio do Recife	https://ensaiosclinicos.gov.br/rg/RBR-2z28qv	<NULL>	Residents in an endemic area of filariasis; of both sexes; age from 18 to 75 years old; who had lymphedema located in the leg, below the knee, unilaterally or bilaterally, ranked from stage II to stage V, according to Dreyer.	Will be excluded from the study patients with lymphedema above the knee (thigh), patients who are doing another treatment to reduce lymphedema, except patients on use of topical antifungal drugs and prophylactic antibiotics for secondary infections; have performed physical therapy for lymphedema in the three months prior to inclusion in the study; introduce infectious processes active and untreated during the project; present thrombophlebitis; have contraindications for manual lymphatic drainage (active neoplasms at the site of drainage, cellulitis, deep vein thrombosis in the acute phase, cardiac insufficiencies, liver and kidney desconpensada and uncontrolled hypertension); have contraindications for compressive bandaging (significant artery diseases in the lower limbs and neoplastic degeneration of lymphedema); present conditions that may compromise the sensitivity and also the functioning of the muscular system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-39znmt	Evaluation hip conditions in childhood and adolescents	Recruitment completed	Observational	2015-10-31	<NULL>	<NULL>	643	Clinical and functional evaluation of children and adolescents with hip conditions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-09-16	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-39znmt	<NULL>	Patiens with slipped capital femoal epiphysis. Patient skeletal immature during the basis treatment and between 8 and 21 years during the final evaluation. Treatment performed in the same institutuion, with all documentation available regarding imaging and history	No acceptance in participating on research ou parents disagreement. Surgery performed after the ain surgical procedure that could alter the proposed evaluation. Incomplete documentation or loss of follow-up, making statistical analysis less reliable. Stiffness of the hip. Osteoarthritis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-5xqfds	Respiratory support during physical activity in Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2015-10-31	<NULL>	<NULL>	644	Effects of two ventilatory support modalities on exercise tolerance and dynamic hyperinflation in Chronic Obstructive Pulmonary Disease	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-05	Hospital Universitário Maria Aparecida Pedrossian - HUMAP / EBSERH	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-5xqfds	<NULL>	Patients of both sexes;age between 40 and 75 years; patients with COPD stages 2,3 and 4 according to the panel GOLD criteria, which are exacerbation-free for at least two months, in regular use of prescription drugs; sinus rhythm; the evaluated patients should be able to perform spirometry and cardiopulmonary exercise testing; fall of CI&gt; 150 mL from baseline at the end of incremental exercise testing.	Recent Myocardial Infarction (less than 6 months), unstable angina, complex ventricular arrhythmia with hemodynamic instability; continuous oxygen therapy need or SaO2 &lt;90% at rest; Atrial Fibrillation chronic; inability to ambulation by neuromuscular, orthopedic or psychological limitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-8nv7zn	Exercise&apos;s effects during hemodialysis in blood tests in patients with Chronic Kidney Disease	Recruitment completed	Intervention	2015-10-31	<NULL>	<NULL>	645	Acute Effects of Exercise during hemodialysis on oxidative stress markers in patients with Chronic Renal Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Centro Universitário Metodista - IPA	Hospital Ernesto Dornelles	https://ensaiosclinicos.gov.br/rg/RBR-8nv7zn	<NULL>	Patients with chronic kidney disease on hemodialysis three times a week, for more than six months; both genders, aged 45 to 70 years.	Severe heart diseases; amputation of the lower limbs; cognitive disorders; inability to understand the guidelines to carry out the tests proposed; musculoskeletal and osteo disabling; presence of femoral fistula.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-9wch5m	Evaluation of two alpha-tocopherol capsules effect on maternal and child vitamin E levels	Recruiting	Intervention	2015-10-31	<NULL>	<NULL>	646	Supplementation with alpha-tocopherol on the nutritional status in vitamin E	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9wch5m	<NULL>	Lactating women; normal delivery; term delivery; aged 18 to 40 years.	Women with any clinical sign of disease; infections; syphilis; HIV; gastrointestinal diseases; liver disease; heart disease; diabetes; hypertension; cancer; mental disorder; twin pregnancie; newborn with fetal malformations; history of abortion; use of antithrombotics; use of supplements containing vitamin E during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-5zm9pr	Effects of the Open Lung Concept following ARDSnet Ventilation in Patients with Early ARDS	Data analysis completed	Intervention	2015-11-04	<NULL>	<NULL>	647	Evaluation of a Sequential Ventilatory Strategy in Patients with Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-04	Universidade de São Paulo	Hospital Copa Dor	https://ensaiosclinicos.gov.br/rg/RBR-5zm9pr	<NULL>	Patients with the diagnosis of Distress Respiratory Syndrome presenting PaO2/FIO2 lower than 300 mmHg after 30 min of mechanical ventilation with a PEEP of 5 cmH2O and an FIO2 of 1.0 and a VT ranging from 8 to 10 mL/kg of ideal body weight along with hemodynamically stable parameters (mean arterial pressures higher than 65 mmHg and arterial lactates lower than 3 mg/dL) over the preceding 6 hours.	Patients with the diagnosis of Adult Distress Syndrome for more than 48 h. Diagnosis of pneumothorax. Diagnosis of pneumomediastinum. Bronchopleural fistula. Subpleural blebs. Increased intracranial pressure. Body weight greater than 140 kg. Pregnancy. Coexistent disease with an expected 6-month mortality risk exceeding 50%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-95239p	Multiprofessional Program for Obesity Treatment in adolescents	Recruitment completed	Intervention	2015-11-09	<NULL>	<NULL>	648	Multidisciplinary Treatment of Obesity and Metabolic Syndrome in Adolescents: intensive behavioral approach	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-22	Universidade Estadual de Maringá	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-95239p	<NULL>	Adolescents classified with overweight or obesity according to the criteria established by Cole et. al (2000); concordance of the adolescent and his/her parents/guardians in participating integrally in the interventions.	The exclusion criteria were: endocrine and metabolic diseases previously diagnosed and informed to the pediatrician; long-term alcohol consumption; use of glucocorticoids and psychotropics which could affect appetite regulation; less than 70 % compliance in all multidisciplinary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-5v5bvw	Chewing in Alzheimer&apos;s Disease	Recruiting	Observational	2015-11-09	<NULL>	<NULL>	649	Chewing function in Alzheimer&apos;s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-06	Faculdade de Odontologia de Piracicaba - UNICAMP	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-5v5bvw	<NULL>	"Experimental group: elderly patients with mild Alzheimer&apos;s Disease, totaly or partially edentulous, removable prosthesis wearers.
Control Group: elderly patients with the absence of any type of dementia, totaly or partially edentulous, removable prosthesis wearers."	"Experimental group: the presence of cognitive-behavioral disease different from Alzheimer&apos;s dementia, motor disturbances which make impossible appliying the tests, presence of signs and symptoms of bruxism.
Control group: presence of any kind of dementia or cognitive behavioral disease, movement disorders which make impossible appliying the tests, presence of signs and symptoms of bruxism."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-4gnm8n	Clinical study comparing palonosetron with ondansetron for prevention of nausea and vomiting after uterus surgery under spinal anesthesia with morphine	Recruitment completed	Intervention	2015-11-10	<NULL>	<NULL>	650	Randomized clinical trial comparing palonosetron with ondansetron for prophylaxis of nausea and vomiting after abdominal hysterectomy under spinal anesthesia with morphine	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-01-22	Hospital São Rafael	Hospital São Rafael	https://ensaiosclinicos.gov.br/rg/RBR-4gnm8n	<NULL>	One hundred and thirty patients classified as American Society of Anesthesiologists (ASA) physical status 1 or 2; aged between 18 and 65 years.	Patients who received corticosteroids and antiemetic drugs in the 24 hours before the procedure; ASA physical status III or IV; allergy to medications involved in protocol; situations that contraindicate to perform spinal anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-849jyv	Assessment of a home exercises program with HAM/TSP individuals	Recruitment completed	Intervention	2015-11-14	<NULL>	<NULL>	651	Assessment of a home exercises program with HAM/TSP individuals - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-05	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-849jyv	<NULL>	Individuals with diagnosis of HTLV-1 by ELISA and confirmed by Western Blot test. Have definitive diagnosis of HAM / TSP established according to the diagnostic criteria proposed by the World Health Organization. Having aged 2 to 59 years. Being able to stand. Subscribe to the free and informed consent.	Patients suffering from rheumatic diseases. Patients suffering from orthopedic diseases. Patients suffering from other neurological diseases. Patients with cognitive changes that compromise the understanding of the exercise program and evaluation tools used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-9dxp3k	Efficiency to electric stimulation combined with physical exercise in patients bearers of face pain.	Data analysis completed	Intervention	2015-11-16	<NULL>	<NULL>	652	Effectiveness of transcranial direct current stimulation combined with kinesiotherapy in patients with chronic temporomandibular disorders (TMJ): clinical, randomized, double-blind, placebo controlled.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-04	Irmandade Santa Casa de Misericórdia de São Paulo	Irmandade Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9dxp3k	<NULL>	Person aged between 18 and 60 years; diagnosis of chronic TMD for at least three months, according to the research diagnostic criteria for temporomandibular disorders (Research Diagnostic Criteria for Temporomandibular disorders RDC / TMD); signing the informed consent.	Patients who had: malformations or rheumatologic diseases TMJ; deterioration of articular (signs of arthritis, meniscus dislocation, fractures, tumors or infections), and other causes of pain in the mouth, face or neck (trauma involving area in the past six months, trigemial neuritis, migraine, or herpes zoster in the region); generating the cognitive impairment of communication skills.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-7m7vs2	Psycotherapy and cognitive decrease in elderers	Recruitment completed	Intervention	2015-11-30	<NULL>	<NULL>	653	Psycotherapy in elders with Mild Cognitive Impairment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Instituto de Geriatria e Gerontologia da PUCRS	Instituto de Geriatria e Gerontologia da PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-7m7vs2	<NULL>	Volunteers of both sexes; members of Centro do Idoso; to be 60 or more years old.	Volunteers with Dementia; neurological or degenerative diseases; severe psyquiatric disorders; don&apos;t be available to participate of all research steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-9y73dr	evaluation of 2% chlorexidine in root canal treatment in primary teeth	Not yet recruiting	Intervention	2015-12-02	<NULL>	<NULL>	654	Evaluation of chlorhexidine 2% in pulp therapy for primary teeth with pulp necrosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-19	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-9y73dr	<NULL>	Children 5 to 10 years who have at least one primary molar with pulp necrosis and indication pulpectomy.	indication for extraction during the endodontic procedure; impossibility of collecting the microbiological root canal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-8wk6z9	Survey of oral health conditions in a city of approximately 100,000 inhabitants	Data analysis completed	Observational	2015-12-02	<NULL>	<NULL>	655	Epidemiological survey in a city of approximately 100,000 inhabitants	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-30	Centro Universitário de Lavras	Prefeitura Municipal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-8wk6z9	<NULL>	Volunteers were included in both genders within the 0 age-index to 36 months, 5 years, 12 years, 15 to 19 years, 35-44 years and 65-74 years agreed to participate and signed the Informed Consent (Term Informed Consent)	They excluded those who, for some reason, did not sign the TLCE (Informed Consent and Informed) or did not wish to participate and those who did not have any age surveyed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-3sc9zc	Impact of training with video games in a population of children and adolescents with motor disabilities	Data analysis completed	Intervention	2015-12-07	<NULL>	<NULL>	656	Impact of virtual reality training in a population of children and adolescents with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Universidad de Talca	Telethon Maule, Chile	https://ensaiosclinicos.gov.br/rg/RBR-3sc9zc	<NULL>	Participants with cerebral palsy type spastic diplegia and hemiplegia (male and female); 7-14 years old; Gross Motor Function Classification System (GMFCS) level I and II y volunteers with informed consent and assent	Neurodegenerative diseases &amp; vestibular disorders; mdministration of high and/or moderate doses of anticonvulsants or similar drugs; moderate and severe cognitive impairment; associated impairment of the type visual and auditory uncorrected; osteotendon and muscle previous surgeries in the last 6 months and access Nintendo Wii at home	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5sj53s	Multicenter Study of the Accuracy and Feasibility of the Xpert Ultra Test	Not yet recruiting	Observational	2015-12-16	<NULL>	<NULL>	657	Multicenter Study of the Accuracy and Feasibility of the Xpert Ultra Test	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	National Institute of Allergy and Infectious Diseases (NIAID)	Núcleo de Doenças Infecciosas	https://ensaiosclinicos.gov.br/rg/RBR-5sj53s	<NULL>	"Inclusion Criteria for Case Detection Group
• Age 18 years or above;
• Provision of informed consent;
• Willingness to provide up to 4 sputum specimens at enrollment;
• Willingness to have a study follow-up visit 42 to 70 days after enrollment;
• Clinical suspicion of pulmonary TB (including cough ?2 weeks and at least 1 other symptom typical of TB.

Inclusion Criteria for Drug Resistant TB Group
• Age 18 years or above;
• Provision of informed consent;
• Willingness to provide 3 sputum specimens at enrollment;
• Clinical suspicion of pulmonary TB (including cough ?2 weeks and at least 1 other symptom typical of TB);
• Meets at least one of the following criteria: 
A) microbiologically-confirmed pulmonary TB with documented rifampin resistance who has received anti-tuberculosis therapy for 31 days or less; 
B) known pulmonary TB with suspected treatment failure;
C) history of drug-resistant TB AND off anti-TB therapy for ? 3 months"	"Exclusion Criteria for Case Detection Group
• Receipt of more than two doses (two days) of TB treatment within 6 months prior to enrollment;
• Participants for whom, at the time of enrollment, the follow-up visit is judged to be poorly feasible (e.g. individuals planning to relocate).

Exclusion Criteria for Drug Resistant TB Group
• No exclusion criteria"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5nskyh	The influence of the pilates method on bone health in older women	Data analysis completed	Intervention	2015-12-18	<NULL>	<NULL>	658	The influence of the method pilates on functional capacity and quality of life and bone turnover in elderly women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Faculdade de Medicina de Botucatu - Unesp	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5nskyh	<NULL>	Female participants; of the Open University of the Third Age; aged 60 or older who do not have serious illnesses and who agree and sign the informed consent form.	Decompensated diabetes, severe hypertension, chronic renal failure, liver disease, sequela of stroke, malnutrition, cancer, hyperparathyroidism, hyperthyroidism, severe chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-97trz9	Study to evaluate the safety, tolerability and efficacy parameters of the drug PRX-102 administered by intravenous infusion every 2 weeks for 12 weeks, to adult patients with Fabry disease	Withdrawn	Intervention	2015-12-21	<NULL>	<NULL>	659	A Phase 1/2, Open Label, Dose Ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Exploratory Efficacy Parameters of PRX-102 Administered by Intravenous Infusion Every 2 Weeks for 12 Weeks to Adult Fabry Patients	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2013-12-02	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-97trz9	<NULL>	Symptomatic adult Fabry patients (?18 yrs; Males: plasma and/or leucocyte alpha galactosidase activity (by activity assay) less than lower limit of normal (LLN in plasma=3.2 nmol/hr/ml, LLN in leucocytes=32 nmol/hr/mg/protein); Females: historical genetic test results consistent with Fabry mutations; Globotriaosylceramide (Gb3) concentration in urine &gt; 1.5 times upper normal limit; Patients who have never received enzyme replacement therapy (ERT) in the past, or patients who have not received ERT in the past 6 months and have a negative anti PRX-102 antibody test; Chronic kidney disease - stages 1 or 2 (CKD1 or 2) (Appendix 7) with proteinuria &gt; 200 mg/g protein-to-creatinine ratio or equivalent, measured in a Spot urine sample, demonstrated in at least one of 2 separate samples (1 sample at screening visit and the other from historical data); The patient signs informed consent; Female patients and male patients whose co-partners are of child-bearing potential agree to use a medically acceptable method of contraception, not including the rhythm method	"Participation in any trial of an investigational drug within 30  days prior to study screening; Chronic kidney disease stages 3-5 (CKD 3-5) (Appendix 7); History of dialysis or renal transplantation; 	Angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) therapy initiated or dose changed in the 4 weeks prior to screening ; Severe myocardial fibrosis by MRI (?2 late-enhancement [LE] positive left ventricular segments) (Weidemann et al. 2009); History of clinical stroke; Pregnant or nursing; Presence of HIV and/or HBsAg and/or Hepatitis C infections; Known allergies to ERT; Known allergy to Gadolinium based contrast agents;	Presence of any medical, emotional, behavioral or psychological condition that, in the judgment of the Investigator and/or Medical Director, would interfere with the patient’s compliance with the requirements of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-6wbpbq	Evaluation of analgesic effect of surgical wound Infiltration of Open Cholecystectomy with Bupivacaine 0.25% with adrenaline in patients of santa casa de misericórdia de Sobral	Other	Intervention	2015-12-23	<NULL>	<NULL>	660	Evaluation of analgesic effect of surgical wound Infiltration of Open Cholecystectomy with Bupivacaine 0.25% with adrenaline in patients of santa casa de misericórdia de Sobral	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-17	Santa Casa de Misericórdia de Sobral	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6wbpbq	<NULL>	They should be included in previously healthy patients; ASA (American Society of Anesthesiologist) 1 or 2; between 18 and 70 years; of both sexes; undergoing elective open cholecystectomy surgery.	People will be excluded who do not agree to answer the questionnaire or refuse to validate the consent form; have any allergies to any of the drugs included in the program &apos;s protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-8g2n7y	Pregnancy and intervention to avoid prematurity	Recruiting	Intervention	2015-12-29	<NULL>	<NULL>	661	Quarenta Semanas: Innovative Intervention in Prenatal Care for Reduction of Prematurity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-8g2n7y	<NULL>	They shall include all pregnant women who accept participate in the research performing prenatal clinics in four randomized clinics after signing the Consent Form . One copy of the consent form  will be provided for all participants.	Pregnant women under 18 and with twin pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-6zkm5k	Prevention of pancreatic inflammation after endoscopy of the pancreas and bile duct with anti-inflammatory	Data analysis completed	Intervention	2015-12-29	<NULL>	<NULL>	662	Acute pancreatitis prevention after endoscopic retrograde cholangiopancreatography (ERCP) with anti-inflammatory	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2014-03-30	Julio Carlos Pereira Lima	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6zkm5k	<NULL>	Eligible subjects were all adults who were scheduled to undergo ERCP at our institution.	Exclusion criteria were patients with known contraindication to ketoprofen use, active pancreatitis at the time of ERCP, previous ERCP and refusal to enter in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-28s4hz	Complementary Therapies to reduce stress  and anxiety and to improve quality of life	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	663	Applicability of Complementary Therapies to reduce pain, stress, anxiety and improving quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-28s4hz	<NULL>	"•	Inclusion Criteria: The patients who are treated by the ITIO Reiki Clinic between June and September of 2015 will be invited and 90 people will be randomized (80% power and 95% confidence interval), which have middle and  high level of stress score on the Stress Symptoms List (LSS)"	"•	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants or other energy therapies to manage stress and anxiety. Those who are receiving psychological therapy, however, won’t be excluded and will be oriented to continue such treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-74jtvm	Assessing the effect of a web-based psycotherapy for alcoholists	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	664	Web-based brief psychotherapies for users alcohol and other drugs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-74jtvm	<NULL>	male; alcohol dependent diagnosis; between 18 and 65 years; not be abstinent during 30 days prior to admission to treatment	abuse or dependent diagnosis of other drugs, exception of tobacco; have participated in specialized treatment for alcohol and other drugs problems in the last three months; meet criteria for severe mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-2b2hqh	The n-3 fatty acid supplementation in breast tumor patients	Recruitment completed	Intervention	2015-12-30	<NULL>	<NULL>	665	Effect of supplementation with n-3 fatty acid on nutritional status, quality of life, immune response and the enzyme fatty acid synthase activity in patients with breast tumors in chemotherapy treatment	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2012-02-07	Universidade de Brasília	Secretaria de Saúde do Distrito Federal - CEP/SES	https://ensaiosclinicos.gov.br/rg/RBR-2b2hqh	<NULL>	Treatment naïve breast cancer patients with 18 to 70 years of age, with mammographic image classification of BIRADS 4C or above and malignancy confirmed by biopsy results.	Metastasis or reincidiva, pacemaker user, hematologic disease or other blood disorders that affect the laboratory results, inability to communicate verbally and presence of edema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-3rx9fj	A Study with additional chart review to evaluate clinical and biochemical characteristics and disease progression in patients with mucopolysaccharidosis type IIIB	Recruitment completed	Observational	2015-07-06	<NULL>	<NULL>	666	A prospective cross-sectional and longitudinal study with additional restrospective chart review to evaluate clinical and biochemical characteristics and disease progression in patients with mucopolysaccharidosis type IIIB	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-15	Hospital de Clínicas de Porto Alegre	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3rx9fj	<NULL>	Definitive diagnosis of MPS IIIB; at least 1 years of age (biological age) at the time of written informed consent; understands the full nature and purpose of the study, including possible risks of study procedures; informed consent signature.	Visual or hearing impairments sufficient to preclude cooperation with neurodevelopmental testing; history of poorly-controlled seizure disorder; currently receiving medication which, in the Investigator’s opinion, would be likely to substantially confound interpretation of the results, or has been on the current dose of psychotropic medication for less than 3 months; receiving a newly increased dose of melatonin (e.g., less than 3 months on current dose); previously received an investigational therapy for the treatment of MPS IIIB or has had hematopoietic stem cell transplant (HSCT); in the opinion of the Investigator, the patient has any other prior or ongoing medical condition that may present a safety risk, interfere with study compliance, or confound data interpretation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-366mbj	Effect of extracted natural agent of grape seed on the longevity of adhesive restorations: clinical trial	Recruitment completed	Intervention	2016-01-04	<NULL>	<NULL>	667	Effect of the proanthocyanidin on the longevity of adhesive restoration: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-366mbj	<NULL>	"Patients older than 18 years, with good general health, acceptable oral hygiene,
with return periods of availability in the evaluation and who have at least 5 teeth with non carious cervical lesions - NCCLs; The teeth with lesions should have a normal occlusal relationship with the antagonist, not present prior restorative treatment; The wells should not be latched with minimum depth of 0.5 mm and mesiodistal width minimum of 1 mm."	Patients who have dental caries, periodontal problems, dry mouth, bruxism. Pregnant; breastfeeding; patients who are undergoing orthodontic treatment; teeth with sharp occlusal stress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-2rzt5c	Effect of the use of the anchoring system for patients with chronic peripheral vestibular	Recruiting	Intervention	2014-10-08	<NULL>	<NULL>	668	Effects of the use of the anchor system in the rehabilitation of balance in individuals with chronic peripheral vestibular disorder: randomized blind controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-2rzt5c	<NULL>	"Eligibility criteria fall within individuals of both sexes , aged 50 years, suffering from chronic peripheral vestibular disease with presence of dizziness and decreased body balance, and nonspecific lightheadedness or feeling dizzy, and peripheral etiology and daily occurrence , weekly, monthly for at least three months , in which the symptoms of vertigo , dizziness , postural instability of vestibular origin , are not responding positively to conventional RV , which includes the reorganization of the VOR .
Will be classified as patients who do not respond positively to RV , those who remain with otoneurology symptoms for more than six months after the start of the intervention , no clinical improvement observed .
The diagnosis of chronic peripheral vestibular disease will be confirmed at the Otolaryngology Department of Ophthalmology , Otorhinolaryngology and Head and Neck Surgery , Hospital das Clinicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo - FMRP - USP."	Exclusion criteria from the survey include: patients who are using drugs (benzodiazepines and anticonvulsants) acting on the balance, calcium channel blockers (cinnarizine and flunarizine), plus motor, visual or cognitive restrictions that prevent the realization of and reviews proposed intervention, as well as with systemic diseases without drug therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-39mpct	Assessment of health around implants in patients rehabilitated with Removable or Fixed  Prostheses on Implants	Recruiting	Intervention	2016-01-04	<NULL>	<NULL>	669	Peri Implant Health Assessment in patients rehabilitated with Overdentures and Full-arch Fixed Prosthesis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-26	Hospital Universitário Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39mpct	<NULL>	Bimaxillary edentulous; use of double dentures for at least one year; rehabilitation with conventional denture bimaxillary in UFRN; sufficient bone height for implant placement of at least 9,00mm in the mandibular arch.	Diabetes; smoking; osteoporosis; immune deficiency or anticoagulant therapy; patients with neurological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-8ngvnn	Pulpectomy in primary teeth: randomized controlled clinical trial evaluation	Recruiting	Intervention	2016-01-05	<NULL>	<NULL>	670	Pulpectomy in primary teeth: randomized controlled clinical trial evaluation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-25	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8ngvnn	<NULL>	Eligible patients will be select if they present:primary teeth with at least two years of permanence in mouth; teeth with radiographic changes suggesting  apical periodontitis either in root and/or furcation area; cavity that allows restoration with suitable sealing;  and teeth without any previous treatment pulp. Patients should have good systemic health, and the data on health history will be recorded.	Will be excluded from the study: teeth with less than two tears of permanence in the mouth; teeth showing root resorption equivalent to 2/3 or more; presenting radiographic disruption of pericoronal bag of the permanent teeth; primary teeth endodontically treated  in a previous session that not present remission of symptoms;teeth with non-appropriate restorative conditions. Patients with any changes to general, are not included in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-5smzhp	Low-level laser effect on the tooth root treatment	Recruiting	Intervention	2016-01-06	<NULL>	<NULL>	671	Effect of Photobioestimulation therapy on pain after Endodontic treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-14	Universidade Federal do Amazonas (UFAM)	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-5smzhp	<NULL>	Adult patients; with endodontic treatment indication in permanent lower molars; diagnosed with irreversible pulpitis; have contact number to be able to perform the postoperative evaluations	Pregnant patients; administering any medication when treatment; immunocompromised; with hypersensitivity to non-steroidal anti-inflammatory drugs; patients who have teeth with endodontic complications (calcifications, external or internal resorption, partial formation of apical summit with dental drilling, with longitudinal or vertical fractures and severe periodontal disease); patients who can not have endodontic treatment completed in the same session; Patients who for any reason can not be contacted by phone for the evaluation of pain after endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-38wgx6	Laser and LED on the healing of cardiac surgery incision	Recruitment completed	Intervention	2012-05-01	<NULL>	<NULL>	672	Photobiomodulation with the use of low-level laser and LED in the sternotomy and saphenous repair process of postoperative patients in coronary artery bypass grafting	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2011-10-25	Faculdade Novafapi	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-38wgx6	<NULL>	Were included individuals who perform elective coronary artery bypass grafting with saphenous vein graft, undergoing cardiopulmonary bypass, hemodynamically stable and who agree to participate in the study by signing the  Consent Term.	Diabetic, morbidly obese with a body mass index (BMI) greater than 40 kg/m2, history of previous thoracic surgery, urgent and emergency surgery, respiratory failure, renal failure, low cardiac output syndrome, need for circulatory assistance using of intra-aortic balloon, subjects who developed complications that resulted in changes to the protocol of analgesia, those showing the period of preoperative hospitalization over 48 hours, presence of coagulopathy, malignancy, renal failure, respiratory tract infections, urinary and endocarditis, as well as those who refused to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-4bfx9c	A phase III study for the evaluation of the immunogenicity and reactogenicity of GSK Biologicals&apos; Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 season Southern Hemisphere) in adults 18 years of age and above	Recruitment completed	Intervention	2016-01-06	<NULL>	<NULL>	673	201959 (FLU D-QIV-017) - A phase III study to assess immunogenicity and reactogenicity of GSK Biologicals&apos; Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 season southern hemisphere) in adults 18 years of age and above	<NULL>	3, non-randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-04-29	GlaxoSmithKline Biologicals	GlaxoSmithKline Biologicals	https://ensaiosclinicos.gov.br/rg/RBR-4bfx9c	<NULL>	Male and female subjects aged 18 years or above at the time of vaccination; healthy with well-controlled chronic diseases;  will comply with the requirements of the protocol and give written informed consent. Female subjects of non-childbearing potential. Female subjects of childbearing potential may be enrolled in the study, if the subject has practiced adequate contraception for 30 days prior to vaccination, and has a negative pregnancy test at screening and on the day of vaccination, and has agreed to continue adequate contraception during the entire treatment period and for two months after completion of the vaccination series	Use of any investigational or non-registered product, drug or vaccine, other than the study vaccine during the period starting 30 days before the dose of study vaccine or planned use during the study period; any medical condition that in the judgment of the investigator would make intramuscular injection unsafe; chronic administration, defined as more than 14 consecutive days, of immunosuppressants or other immune-modifying drugs within six months before study start or planned administration during the study; planned administration of a vaccine not foreseen by the study protocol in the period starting 30 days before the study vaccination and during the entire study period; administration of immunoglobulins and/or any blood products within the three months preceding the first dose of study vaccine or planned administration during the study period; administration of an influenza vaccine within the 6 months preceding the study start or planned use of such vaccines during the study period; concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product; clinically or virologically confirmed influenza infection within the six months preceding the study vaccination; any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination; acute disease and/or fever at the time of enrollment; acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory testing performed at the screening visit; chronic underlying disease not stabilised or clinically serious;history of chronic alcohol consumption and/or drug abuse; history of Guillain-Barré syndrome; history of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine, including latex; history of severe adverse reaction to a previous influenza vaccination; anaphylaxis following the administration of vaccine(s);  pregnant or breastfeeding female; subject planning to become pregnant or planning to discontinue contraceptive precautions during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-2w55vq	Study to evaluate the occurrence of Dengue in areas with higher concentrations of cases in Brazil	Recruiting	Observational	2016-01-06	<NULL>	<NULL>	674	An epidemiological surveillance study to evaluate the incidence of Dengue in brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-02-17	GlaxoSmithKline Biologicals	GlaxoSmithKline Biologicals	https://ensaiosclinicos.gov.br/rg/RBR-2w55vq	<NULL>	Written and signed informed consent; male or female at least 6 months of age at the time of enrollment; subject and/or subject’s parent(s) who the investigator believes can comply with the requirements of the protocol and Subject who plans, at the time of enrollment, to remain at same residence/study area during the one year study period	Child in care; participation (current or planned) in another epidemiological study or in a clinical trial that would conflict with the current study, based on investigator’s judgement and terminal illness or severe mental incapacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-46st4w	Ear cavity closure with frozen bone for otitis revision surgery	Recruitment completed	Intervention	2016-01-06	<NULL>	<NULL>	675	Mastoid cavity obliteration with particulated fresh frozen bone in revision surgery for patients with chronic otitis media with cholesteatoma	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-07-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Anna Carolina de Oliveira Fonseca	https://ensaiosclinicos.gov.br/rg/RBR-46st4w	<NULL>	Adults, with clinical indication of mastoidectomy revision surgery due to chronic otitis media.	diabetes, bone metabolism diseases, smokers, coagulation disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-3v7cmx	Functional training for elderly with Alzheimer&apos;s disease	Recruitment completed	Intervention	2016-01-07	<NULL>	<NULL>	676	Effects of functional training on cognition and functional capacity in elderly with Alzheimer&apos;s disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-30	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3v7cmx	<NULL>	Elderly patients with a clinical diagnosis of Alzheimer&apos;s disease; level of severity of mild to moderate; with ambulation preserved without visual, hearing loss, vertigo syndrome or other limitations that hinder the locomotion or the attainment of cognitive tests; do not exhibit other neuropsychiatric conditions.	Elderly people with Alzheimer&apos;s disease with heart disease or other neurological diseases; with reduced mobility; do not attend a minimum 80% attendance of the proposed training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-3w3vnc	Effects of telephone interventions on adherence to receive the results of examination of prevention of cervical cancer	Recruitment completed	Intervention	2016-01-07	<NULL>	<NULL>	677	Effects of educational and behavioral intervention by telephone on accession to receive the Pap smear report	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-30	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3w3vnc	<NULL>	Have initiated sexual activity; take the examination for the prevention of cervical cancer in the period of data collection and own mobile or landline.	A minor; present some pathology related to mental processes, speech articulation or hearing that it would not answer the questionnaire and to participate in educational or behavioral intervention; not have done for any reason, the Pap test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-6fv66n	The use of expiratory pause on the ventilator during the lung secretions aspiration procedure as the air cleaning technique	Recruitment completed	Intervention	2016-01-08	<NULL>	<NULL>	678	The use of expiratory pause during vacuuming in a closed system such as bronchial hygiene technique	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6fv66n	<NULL>	Be between 24 to 72 hours on mechanical ventilation; closed suction system; hemodynamically stable stability with mean arterial pressure and equal to or greater than 60 mmHg with noradrenaline doses less than 1?g / kg / minute.	Pneumothorax; undrained hemothorax; subcutaneous emphysema; tuberculosis; Influenza Influenza A; who refuse to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-6cvprm	Effects of two training programs: aerobic and resistance in muscle strength, physical fitness and muscle pain in participants with blood pressure, abdominal obesity, cholesterol and glucose levels impairments	Recruiting	Intervention	2016-01-12	<NULL>	<NULL>	679	Effects of two periodized training programs: aerobic interval and resistance training in isokinetic strength, physical fitness and clinical parameters on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6cvprm	<NULL>	Sedentary men; between 35 and 60 years; diagnosed with Metabolic Syndrome	use of drugs or medications, except those used to control the risk factors of Metabolic Syndrome; presenting amenorrhea; inflammation and or infection; episode of muscle tendon or osteo articular injury in the upper, lower limbs and or spine in the last three months; respiratory diseases; neurological disorders and cardiovascular disease at high risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-9gh46r	Effects of different modalities and different intensities of physical rehabilitation on the Elimination of protein in the urine in patients with chronic kidney disease not requiring dialysis hypertensive origin	Not yet recruiting	Intervention	2016-01-12	<NULL>	<NULL>	680	Action of different modalities and intensities of physical rehabilitation on albuminuria of patients with non-dialysis dependent hypertensive nephrosclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Faculdade de Medicina de Botucatu	Prefeitura Municipal de Itaí	https://ensaiosclinicos.gov.br/rg/RBR-9gh46r	<NULL>	Minimum age of 18 years; patients with chronic kidney disease in hypertensive origin; with elimination of the protein albumin in the urine with more than 30 milligrams per gram of creatinine, family history of hypertension, hypertension preceding the elimination of prteína; the presence of ventricular hypertrophy on electrocardiogram signals.	Patients who are on dialysis; Albuminuria greater than or equal to 2,000 milligrams per gram of creatinine; History or evidence of angina or myocardial infarction; Treadmill exercise test positive for coronary heart disease; Cardiac arrhythmias; Musculoskeletal restrictions that preclude participation; Hemodynamic instability; Diabetic patients; Exposure to nephrotoxins; Evidence glomerular diseases; Presence of systemic diseases that can affect the kidneys.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-2qfjpv	The effectiveness of HIV preventive methods in Brazilian health service	Not yet recruiting	Intervention	2016-01-13	<NULL>	<NULL>	681	Pre- and post-exposure prophylaxes and the combination HIV prevention methods: protocol for a pragmatic clinical trial at public healthcare clinics in Brazil	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-09-01	Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo	SAE Vila dos Comerciários - SMS de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2qfjpv	<NULL>	"Seek care in service for the use of PEPsexual or report sexual exposure to HIV in a consensual relationship in the last 30 days in accordance to the criteria defined by the Health Ministry for use of prophylaxis;
16 years of age or over; 
Negative anti-HIV test at the time when the clinic is sought, or positive anti-HIV serological test with negative/indeterminate western blot;
Having started PEPsexual at the clinic or having been referred for clinical follow-up soon after the initial attendance at an emergency service, provided that information on serological status, sexual exposure and prescribed therapy is available;
Having signed the free and informed consent statement."	Having sought PEPsexual for the purpose of assisted reproduction or due to occupational exposure or sexual violence;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-86dtnz	Effects of the restorative material in atraumatic restorations	Recruitment completed	Intervention	2016-01-14	<NULL>	<NULL>	682	A 24-month randomized clinical trial of ART restorations in Class II cavities with two glass ionomer cements	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-20	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-86dtnz	<NULL>	Students aged 4 to 12 years, of both genders and having deciduous and/or permanent teeth with caries lesions involving the proximal surface, visible during clinical examination and classified as score 05 ICDAS (International Caries Detection and Assessment System); the cavities should have an occlusal opening compatible with the sizes of the dentin excavators according to the ART technical protocol.	Students with deciduos and/or permanent teeth with pulp pathology characterized for facial edema and fistula, volunteers whose parents do not agree with the Informed Consent Form, non-collaborative children, volunteers with special needs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-3hrrmx	The effect of Srenght training in patients quality of life in hemodialysis	Recruitment completed	Intervention	2016-01-15	<NULL>	<NULL>	683	Strength Training and patient quality of life hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3hrrmx	<NULL>	Being in clinical treatment; Physical inactivity is at least six months; have release Midica for physical activity.	Be carrying a disease of the muscular system; articulate; bone and connective tissue diagnosed in the initial application in recruitment. have arthropathy; systemic connective tissue diseases; condropatias; heart disease; osteopathies; make use of beta-blocking drugs origin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-4m42nq	A study of eltrombopag in combination with azacitidine for subjects with low platelet counts due to intermediate 1, intermediate 2 or high risk Myelodysplastic Syndromes.	Recruiting	Intervention	2016-01-15	<NULL>	<NULL>	684	TRC112121 A phase III, randomized, double-blind, placebo-controlled, multi-center eltrombopague or placebo in combination with azacitidine in patients with Myelodysplastic Syndrome with IPSS intermediate-1 classification, intermediate-2 and high-risk.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-05-23	GlaxoSmithKline Brasil	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-4m42nq	<NULL>	Myelodysplastic Syndromes risk ranked at Intermediate 1, intermediate 2 or high according to IPSS;At least one platelet count lower than 75 Gi/L;Eastern Cooperative Oncology Group(ECOG) Status 0-2.;  Adequate baseline organ function	Previous treatment with hypomethylating agent or induction chemotherapy for MDS;History of treatment with eltrombopag, romiplostim or other TPO-R agonists;Previous allogeneic stem-cell transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-892mp4	Effect of perineal exercises to prevent recurrence of vulvar discharge and improve female sexuality	Terminated	Intervention	2016-01-18	<NULL>	<NULL>	685	"Effectiveness of therapeutic exercise applied to the pelvic floor muscles to prevent recurrence of Vulvovaginitis and improve female sexuality:
randomizad clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Estadual de Campinas - Unicamp	Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-892mp4	<NULL>	Women will be included among 18 and 45; sexually active; have recurrent candidiases (RVVC) or bacterial vaginoses (RBV); be willing to participate in therapy sessions urogynecological and accept; voluntarily sign the free and informed consent form (TCLE)	"Women will be excluded: menopausal; pregnant, in prophylactic treatment for RVVC or RVB; with
Symptoms of urinary and/or fecal incontinence; prolapse 2 and 3 have pelvic organ; vaginal stenosis and complaining of chronic pelvic pain have psychiatric disorders; restriction
musculoskeletal; neoplastic disease and/or chronic degenerative diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-6gtj9k	Effectiveness of the bleaching technique delivered in custom-made or prefilled disposable trays	Recruitment completed	Intervention	2016-01-18	<NULL>	<NULL>	686	Effectiveness and clinical parameters evaluation of bleaching technique with 10% hydrogen peroxide dispensed in individual or pre-loaded trays	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	Centro de Pesquisas Odontológicas São Leopodo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6gtj9k	<NULL>	being aged between 18 and 30 years; presence of at least 20 sound teeth; presence of central and lateral incisors or upper and lower canines with at most 1/6 of the buccal surface restored.	teeth with an initial color of B1 assessed using a shade scale (Vitapan Classical, Vita, Germany) or spectrophotometer (VITA Easyshade® Advance, Vita, Germany); people wearing dentures or fixed/removable orthodontic appliances; pregnant or breastfeeding women; smokers; history of dentin sensitivity; presence of active caries in enamel or dentin; periodontal disease or other oral diseases; tetracycline-pigmented teeth; patients who had their teeth bleached before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-326msc	Spinal blood supply characteristics: comparison between patients with and without aortopathy.	Data analysis completed	Observational	2016-01-19	<NULL>	<NULL>	687	Adamkiewicz artery characteristics: comparison between patients with and without aortopathy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-10-17	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-326msc	<NULL>	Both genders; age more than 18 years; aortic Angio-CT performed with the Aquillion One device at Hospital das Clínicas by predefined protocol; acceptance of terms and exams protocol	Exclusion criteria were previous surgery of the descending aorta, individuals with diseases liable to affect the results due to the presence of collateral circulation (Takayasu’s arteritis, coarctation of the aorta), individuals with paraplegia or tetraplegia, known allergy to the radiological contrast medium, concomitant inclusion in another study in which its protocol could interfere, aortic intramural hematoma and penetrating ulcer of the aorta, refusal to participate and flawed aorta opacification due to technical reasons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8w369s	The effect of medications to combat the generated sensitivity after the tooth whitening office	Not yet recruiting	Intervention	2016-01-19	<NULL>	<NULL>	688	Effectiveness of two drugs in controlling sensitivity generated by office tooth whitening: A clinical, randomized, blinded trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-09	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8w369s	<NULL>	Individuals must be at least 18 years old, doesn&apos;t have hipersenssibilidade to ibuprofen and codeine; be nonsmoking; have teeth with greater color A2; possess good oral and general health; have front teeth upper and lower vital; free of cavities or restorations without cervical lesions and without periodontal disease.	Pregnant women will be excluded or breastfeeding; people with discolored teeth caused by tetracycline; with fluorosis; hyperplasia; endodontic treatment or needing root canal treatment; and parafunctional habits. People who have any condition that may cause sensitivity such as recession or exposure of dentin are excluded from this study to minimize confusion of experimental variables or side effects of bleaching. Participants who report a health problem history in the stomach; heart; kidney; or liver or participants using any continuous drug with anti inflammatory action are also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-52pq3b	Bed bath with tub / basin and bath bag: micro-biological case-control and cost evaluation	Recruiting	Intervention	2016-01-22	<NULL>	<NULL>	689	Conventional Bath bed and Bath Bag: case-control microbiological, cost evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-52pq3b	<NULL>	dependence on the nursing team; impaired physical mobility; bedridden in the ward admission; up to 48 hours of hospitalization.	partial dependence on the nursing team; They are not bedridden; show on mechanical ventilation; infectious disease of skin and soft tissue (cellulitis; erysipelas; eczema); skin ulcers; pressure; venous; infectious or tumor; previous use of antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8t4bf3	Supplementation of different branched chain amino acids in the treatment of hepatic encephalopathy in cirrhotic patients: randomized, double-blind, controlled trial	Recruitment completed	Intervention	2016-01-22	<NULL>	<NULL>	690	Supplementation of different branched chain amino acids in the treatment of hepatic encephalopathy in cirrhotic patients: randomized, double-blind, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-03	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho	Ajinomoto - Divisão Aminoscience Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8t4bf3	<NULL>	Literate individuals aged over 18 years; Presence of cirrhosis (defined by liver biopsy or by a combination of clinical criteria: physical examination with signs of liver failure and / or portal hypertension, endoscopic examination with the presence of esophageal or gastric varices, and / or radiological imaging, ultrasound or computed tomography abdominal, with evidence of chronic liver disease and / or portal hypertension); Presence of Hepatic Encephalopathy (HE) type C ranging from Minimal Hepatic Encephalopathy (MHE) to grade III.	Fulminant hepatic failure (Hepatic Encephalopathy type A); Hepatic Encephalopathy (HE) secondary to porto-systemic shunts without intrinsic liver disease (HE type B); Severe neuropsychiatric disorders; Obstruction or inflammatory bowel disease; Severe renal impairment (serum creatinine greater than twice normal); Shock (septic, hemorrhagic, neurogenic, cardiac, anaphylactic or mixed); Misuse of alcohol or alcoholic hepatitis in the last six weeks; Use of food supplement with Branched Chain Amino Acids (BCAA);  HE grade IV; Recent use of lactulose, antibiotics or L-ornithine L-aspartate (If these medications are started less than a week of the initial intake of the suplementation, the patient will be temporarily excluded from the study, however, chronic use will not be considered an exclusion criterion); Patients in treatment of hepatitis C;  Neoplasia; Pregnancy, Lactation and Obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2xj368	Influence of resveratrol (grappe seed extract) on heart beats at rest and during exercise in adults with hypertension.	Recruiting	Intervention	2016-01-22	<NULL>	<NULL>	691	Effects of resveratrol supplementation on heart rate variability in adults with hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-03	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Fabianne Magalhães Girardin Pimentel Furtado	https://ensaiosclinicos.gov.br/rg/RBR-2xj368	<NULL>	Adults of both genders, aged between 35-70, with hypertension.	"No additional orthopedic deficiencies impairing ambulation
Uncontrolled high blood pressure 
Diabetes or cardiomyopathy
Regular wine or grape juice drinkers
People who exercise regularly 
People with intolerance to resveratrol"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-95xmrb	Relaxing effect on sleep quality, depression and stress in people with multiple sclerosis	Recruitment completed	Intervention	2016-01-25	<NULL>	<NULL>	692	Progressive muscle relaxation effect on sleep quality , depression and stress in people with multile sclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal do Espírito Santo	Hospital Cassiani Antônio de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-95xmrb	<NULL>	"Having diagnosis of MS for at least 6 months, having been diagnosed with relapsing-remitting MS; They are receiving treatment with an immunomodulator; have
Expanded Disability Status Scale (EDSS) less than or equal to 5.0; Aged between 18 and 65; have not had any outbreaks during the
3 month period prior to inclusion in the study; Media have at home (CD, MP3)."	"Being hospitalized at the time of data collection or outbreak at the time of data collection; have physical and / or mental changes that prevent the collection of data, such as motor or cognitive deficits; Continuous use of psychotropic medications (eg, antidepressants,
benzodiazepines, antipsychotics or other stimulants); make use of complementary health practices (eg, yoga, pilates, meditation, psychotherapy, reik, relaxation)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8pchqf	The results of pharmacist consultations for the patient&apos;s health and health care system economy.	Data analysis completed	Intervention	2016-01-25	<NULL>	<NULL>	693	Pharmaceutical Care in the hypertension: clinical, economic and social impact.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo	Thais Rodrigues Penaforte	https://ensaiosclinicos.gov.br/rg/RBR-8pchqf	<NULL>	Hypertension, over 18 years in treatment.	Previously be gone, cognitive impairment, pregnant and lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8bxdd3	Use of positive pressure face mask as a resource treatment in postoperative cardiac surgery	Recruiting	Intervention	2016-01-27	<NULL>	<NULL>	694	Analysis of the use of noninvasive ventilation in patients after cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-09	Universidade Federal de Sergipe	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-8bxdd3	<NULL>	Inclusion criteria include: patients admitted to the Hospital Charitable Foundation Surgery in preoperative procedure for cardiac surgery (valvuloplasty or valve replacement and / or CABG); both sexes aged 20 and 70 years; absence of psychiatric condition, cognitive decline or dementia influencing the communication process; absence of neuromuscular or musculoskeletal disorder or recent unresolved that may affect your ability to walk or mobility.	Patients will be excluded conditions : contraindications to the use of therapies with noninvasive positive pressure as decreased level of consciousness , ineffective cough , airway obstruction , abdominal distension , vomiting , upper gastrointestinal bleeding , hemodynamic instability , coronary syndrome acute , complex arrhythmias , facial trauma , surgery , esophageal barotrauma undrained ; patients requiring mechanical ventilation , invasive for over 24hrs , patients who refuse to sign the consent form or refuses to perform the treatment , patients in the control group at any time of the present study indicate ventilatory support both invasive and non -invasive clinically by dyspnea characterized by: increased respiratory rate &gt; 25 bpm , paradoxical pattern , use of accessory muscles , runs and fall of oxygen saturation ; surgical complications that impede patient participation in research .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-4pp8j6	Effect of exercise and dietary control on muscle strength, cardiorespiratory fitness, blood variables and body composition in postmenopausal women	Data analysis completed	Intervention	2016-01-28	<NULL>	<NULL>	695	Effects of physical training and dietary control on muscle strength, cardiorespiratory fitness, blood biochemical variables and body composition in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pp8j6	<NULL>	Women; postmenopausal; age between 50 and 79 years at the date of valuation; no physical limitations or any health problems that prevent the implementation of evaluations; possess a medical certificate to perform the cardiorespiratory fitness test, participate in the concurrent training and eating 1.5 ounces per day of taurine;  perform all evaluations; sign the consent form and formal clarification for study participation.	"Hormone replacement therapy; hypertension;
hysterectomy; accumulate three consecutive absences or four non-consecutive absences during the month"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2qpsxw	Comparative analysis of the single photon diagnostic  tecnology (Spect/CT), with radiopharmaceutical application of Ecdg-99mTc , and computed tomography (CT)- in patients with Lung Cancer.	Not yet recruiting	Intervention	2016-01-28	<NULL>	<NULL>	696	A phase III study comparing the accuracy of Ecdg 99mTc SPECT/CT against CT for the diagnosis and staging of subjects with clinical and radiological  evidence  consistent with a diagnosis of lung cancer	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-10-15	Esho Empresa de serviços hospitalares S.A. – Hospital Pasteur	CCTECH Tecnologia em Imagem Molecular Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2qpsxw	<NULL>	Male or female subject with at least 18 years of age.  Women may not be pregnant or breast-feeding, and, for those in post-menopausal, the minimum period shall be 12 months for natural process, or 6 months in surgical cases. Agree to adhere to one of the birth control methods (contraceptives) as proposed protocol. Have evidence of lung cancer or CT study results consistent with a diagnosis of lung cancer. Not be receiving cancer treatment (surgery, radiotherapy and / or chemotherapy) or if the person has had lung cancer in the past, all previous therapy should have completed at least 3 months prior to the inclusion in the study. Must have a score in the instrument Eastern Cooperative Oncology Group (ECOG) less than or equal to 2. Present satisfactory laboratory values (l alanine aminotransferase less than or equal to 2.5 x ULN,  aspartate aminotransferase less than or equal  to 2.5 x ULN; less than or equal  to 2.5 x ULN; bilirubin less than or equal to 2.0 x ULN)	If there are any clinically relevant safety concerns (laboratory, ECG, physical examination, other) which, in the opinion of the investigator, put the subject in unnecessary risk if the subject were to participate. If, in the last 3 months, the patient has been submitted to any treatment for Cancer (radiation therapy, surgery or chemotherapy). Diabetic patient with insulin dependency. Weight limit higher than recommended by SPECT / CT and CT table. Known hypersensitivity to ECDG or contrast, or other compound, including any of the inactive ingredients. Pregnancy or suspected pregnancy, lactation, or planned pregnancy (male and female partners). Clinically significant mental illness that compromises the conduct of the study (which should be determined by the investigator).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-4nwmk4	Evaluation of atraumatic restorative treatment (ART) in the family health strategy of Teresina, Piauí	Recruiting	Intervention	2016-01-28	<NULL>	<NULL>	697	Evaluation of atraumatic restorative treatment (ART) in the family health strategy of Teresina, Piauí	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	UNIVERSIDADE FEDERAL DO PIAUÍ	Profa Dra Marcoeli Silva de Moura	https://ensaiosclinicos.gov.br/rg/RBR-4nwmk4	<NULL>	good general health, present dentin caries lesion in vital primary teeth without pain symptoms or signs of pulp envelopment	Deep cavities, presence of fistula, pulp envelopment or mobility of the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-56p5mj	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	Recruiting	Intervention	2016-01-28	<NULL>	<NULL>	698	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-16	Centro Universitário da Faculdade de Saúde, Ciências Humanas e Tecnológicas do Piauí	Nabor Bezerra de Moura Júnior	https://ensaiosclinicos.gov.br/rg/RBR-56p5mj	<NULL>	"Patients with malignant pleural effusion requiring chest drainage
Agreement  with the research and signing of the Informed Consent Form."	"Patients less than 18 years-old
Empyema
Post-operative period of thoracic surgery
Patients using sedatives and / or mechanical ventilation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2wtwjz	Spiritual well-being resulting from passive listening of sacred music in bereaved relatives: randomized controlled trial	Data analysis completed	Intervention	2016-01-28	<NULL>	<NULL>	699	Spiritual well-being resulting from passive listening of sacred music in bereaved relatives: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-21	Programa de Pós-Graduação em Enfermagem na Saúde do Adulto da Escola de Enfermagem da Universidade de São Paulo	Vladimir Araujo da Silva	https://ensaiosclinicos.gov.br/rg/RBR-2wtwjz	<NULL>	To be mourning the death of a loved one (parent or spouse), registered in the Women&apos;s Network Against Cancer of Maringa-PR, whose death has occurred for cancer, there is at least one month and a maximum of 12 months; to have participated in the care process at the end of life of their loved one; to reside in the cities of Maringa-PR, Sarandi-PR or Paiçandu-PR; to be 18 years old or more; to have preserved auditory function; to have preserved language&apos;s function to respond to the Spiritual Well-Being Scale and a semi-structured form.	Family members who moved to another city during data collection; family members who presented hearing loss during the data collection; family members that present, in the course of data collection, cognitive difficulty expressing one&apos;s perceptions; family members who experience the loss of other family members during the data collection period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-78h48d	Aquatic physiotherapy in pain, daily activities and quality of life in older people with knee Osteoarthritis	Recruiting	Intervention	2016-01-29	<NULL>	<NULL>	700	Effectiveness of aquatic physiotherapy in the perception of pain, functional capacity and quality of life of older adults with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-23	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-78h48d	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age above 60 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-6ddpb3	Prevention program of obesity and eating disorders developed with adolescents from public schools of São Paulo	Recruitment completed	Intervention	2016-01-29	<NULL>	<NULL>	701	Integrated prevention program of obesity and eating disorders: a pilot study, randomized trial comparing the effects of the &quot;New Moves&quot; applied in public schools of São Paulo.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ddpb3	<NULL>	"In both groups is considered as an inclusion criterion:
being female; 
having between 12 and 14 full years; 
agree and sign the consent term of the study (students and their parents)"	"Have 15 years or more; 
practice more than one hour of exercise a day; vomit or use laxatives weekly"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-9yz2pb	Educative practice and maternal stress of premature infant: randomized clinical trial	Recruitment completed	Intervention	2016-01-29	<NULL>	<NULL>	702	Effects of prematurity: mother stress and metabolic programming after hospital discharge /Stress and maternal role after an educational intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	universidade estadual do oeste do parana - unioeste	Hospital Universitário do Oeste do Paraná - HUOP	https://ensaiosclinicos.gov.br/rg/RBR-9yz2pb	<NULL>	Preterm under 37 weeks of gestational age; preterm without malformation; teenager mother following with law responsable; literacy mother.	Preterm has left for adoption; mothers who have related psychiatric problems; mothers who autorelate that are in continuous use of controlled drugs (anxiety or depression); mothers with medical complications or who have gone to death during the study; illiterate mothers; teenagers mothers without law companion; mothers who did not attend the consultations on the follow-up clinic between the 3rd and 6th month after discharge from the Neonatal Intensive Care Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-3tv5mr	Postpartum depression and Emotion Recognition: clinical study of the acute effects of Oxytocin	Recruiting	Intervention	2016-01-29	<NULL>	<NULL>	703	Postpartum Depression and Facial Expression Recognition: clinical, randomized study involving the acute effects of Oxytocin	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2015-11-01	Faculda de Medicina de Ribeirão Preto	Mariana Fortunata Donadon	https://ensaiosclinicos.gov.br/rg/RBR-3tv5mr	<NULL>	Check shall be the initial inclusion criteria (age above 18 years, post-pregnancy postpartum (20-45 days after the baby&apos;s birth), number of previous pregnancies) and those that meet the criteria will be invited to participate in the study.	"mothers with absence of diagnosis of depression post partum;
age under 18
post-pregnancy than in the postpartum period (20-45 days after the baby&apos;s birth;
mothers with birth complications"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-2v3k6r	Speech changes produced by upper orthodontic retainers	Recruitment completed	Intervention	2016-01-29	<NULL>	<NULL>	704	Speech changes produced by upper orthodontic retainers: Prospective Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-20	Faculdade de Odontologia de Bauru - USP	Diego Coelho Lorenzoni	https://ensaiosclinicos.gov.br/rg/RBR-2v3k6r	<NULL>	Brazilians who speak the native Portuguese; acceptable sagittal occlusal relationship, with molars class I or variations of up to ¼ of II or III class.	Presence of cross bite, open bite, overbite greater than 50%, overjet greater than 4 mm, crowding greater than 2 mm and multiple anterior diastema; orthodontic treatment recently finalized (less than 1 year); recently used upper orthodontic retainer (less than 2 months); presence of ankyloglossia; presence of TMD; presence of previous change in speech.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-2x4gm7	Proposal for prenatal nutritional assistance in primary care in Manguinhos area.	Recruitment completed	Intervention	2016-01-29	<NULL>	<NULL>	705	Proposal for prenatal nutritional assistance in primary care in Manguinhos area.	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-02-06	Escola Nacional de Saúde Pública da Fundação Oswaldo Cruz	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2x4gm7	<NULL>	Pregnant women with a single fetus, without chronic diseases prior to pregnancy and who were followed by the prenatal clinic of the study.	Pregnant women street residents; who have had abortions and stillborn son during the pregnancy; those who moved to another area that was not covered by the family clinic of the study and who did not present data on postpartum.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8cchby	Breathing exercises before surgery abdominoplasty	Recruiting	Intervention	2016-02-01	<NULL>	<NULL>	706	Phyisical therapy preparation in respiratory complications in abdominoplasty Prevention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cchby	<NULL>	Feminine gender; Body Mass Index between 20 and 30 kg/m2; with abdominal deformity type III Nahas; and type B Nahas.	Obstructive or restrictive respiratory disease; with abnormal chest x-ray; smokers; those with systemic diseases; subject to previous abdominal surgery; with supra-umbilical scars and post bariatric surgery with great weight loss; not carrying out the pre-breathing exercise operative as directed; or not attending the physical therapy session for the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-48c29w	Effect of strength training in the vascular function of hypertensive elderly	Data analysis completed	Intervention	2016-02-01	<NULL>	<NULL>	707	Effect of strength training in the vasodilatory response of hypertensive elderly: related mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-48c29w	<NULL>	Aged between 65 and 75 years; have not committed any type of regular exercise (more than 2 days per week) over a period of 6 months prior to study entry; have mild essential hypertension (stage I).	Have history or evidence of hematologic disease; peripheral vascular disease; stroke; obesity; diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-95sxqv	Evaluation of related knowledge of pelvic floor, loss of urine and sexual dysfunction among women participating in a pelvic floor educational group	Data analysis completed	Intervention	2015-12-14	<NULL>	<NULL>	708	Evaluation of related knowledge of pelvic floor, urinary incontinence and sexual dysfunction among women participating in a pelvic floor educational group	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo FMRP-USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-95sxqv	<NULL>	Women who are interested in participating in an education group of the pelvic floor. Women capable of interacting in an interview. Women who agree to participate after the clarification of the researchers.	Women who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-4xzjny	Flour of tamarind as a tool for the health control of diabetic patients	Recruitment completed	Intervention	2016-02-03	<NULL>	<NULL>	709	Flour of tamarind as an adjuvant in metabolic control of diabetic patients.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-16	Universidade Estadual do Ceará - UECE	Embrapa Agroindústria Tropical	https://ensaiosclinicos.gov.br/rg/RBR-4xzjny	<NULL>	Male or female; presence of diabetes mellitus type 2 diagnosed at least two years; being regularly monitored by the institution; be adult or elderly; having a body mass index (BMI) of overweight; be in use of oral hypoglycemic agents; not be in use for insulin; have no known diseases except commonly associated with the presence of diabetes mellitus type 2; live in the city in order to facilitate monitoring. Search sample is 200 patients.	Any factor that limits anthropometric assessments of weight, height or circumference.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-44zfmv	Comparison between two physical therapy treatments for patients with limited movement of elbow joint and wrist	Data analysis completed	Intervention	2016-02-03	<NULL>	<NULL>	710	Comparative study of the effects of classical kinesiotherapeutic treatment and its effects coupled with Maitland technique in patients with limited movement of elbow and wrist	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-10	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-44zfmv	<NULL>	40 male or female volunteers; age between 18 and 70 years; limited range of motion of the wrist or elbow after upper limb fracture healing.	More than one year after the injury; neurological changes in muscle function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5kb5kz	Laboratory and clinical evaluation of resin composite placed in one increment in posterior teeth restorations	Recruitment completed	Intervention	2016-02-11	<NULL>	<NULL>	711	Laboratory and clinical research of a technical insertion of a composite resin in posterior teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-24	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-5kb5kz	<NULL>	Participants must be healthy; be at least sixteen posterior teeth in occlusion; minimum age of 18 years; have at least two caries or defective restorations in need of replacement in posterior teeth (cavities adjacent to the restoration, fractured restorative material or patient choice of aesthetics); the teeth to be restored should be in occlusion with the antagonist and respond positively to pulp vitality test performed with the application of cold (Roeko Endo-Frost, Coltène / Whaledent, Langenau, Germany, the cavities to be restored must have a minimum depth 3 mm (previously verified by bitewing radiography exam and millimeter probe)	We excluded participants with poor oral hygien; with periodontal disease; endodontic treatment; with extensive prostheses (fixed or removable) or orthodontic treatment; with known allergy to resin-based materials or any other material used in this study; patients with chronic use of anti-inflammatories, analgesics and psychotropic drugs; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-54zf73	Prenacel Pregnant: Development and evaluation of a communication strategy to improve quality of antenatal care	Recruitment completed	Intervention	2016-02-12	<NULL>	<NULL>	712	Prenacel Pregnant: Development and evaluation of a communication strategy to improve quality of antenatal care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	Faculdade de Medicina de Ribeirão Preto	Ana Carolina Arruda Franzon	https://ensaiosclinicos.gov.br/rg/RBR-54zf73	<NULL>	Pregnant women and their partners; volunteers; attending prenatal care at one of the 20 health facilities selected to perform the study; aged 18 years or older; with pregancy that presents last menstrual period between November 17th, 2014 and June 1st, 2015.	Not having access to a mobile phone capable of receiving short message service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5mfhkz	Comparison between two surgical techniques for treatment of the primary pterygium	Recruitment completed	Intervention	2016-02-12	<NULL>	<NULL>	713	Comparison between rotation of conjunctival flap and amnionic membrane transplant in pterygium surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Estadual de Campinas	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5mfhkz	<NULL>	Primary Pterygium. Level II Pterygium. Healthy volunteers. Both genders. Age range 18 to 60 years.	Recidivated pterygium. Level I pterygium. Level III pterygium. Current ocular infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5zpphs	Impact of hidrotherapy and dry land exercises in daily activities and quality of life of older people with knee osteoarthritis	Recruiting	Intervention	2016-02-16	<NULL>	<NULL>	714	Impact of physiotherapy aquatic and dry land exercise in functional capacity and quality of life of older adults with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5zpphs	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age above 60 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-49zkm6	Comparison between two methods of caries prevention using two resin-based materials: sealant or infiltrant	Data analysis completed	Intervention	2016-02-17	<NULL>	<NULL>	715	Progression of non-cavitated caries lesions treated with a Resin-Based Selant or a Resin-Based Infiltrant	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-26	Universidade Anhanguera de São Paulo - UNIAN-SP	Universidade Anhanguera de São Paulo - UNIAN-SP	https://ensaiosclinicos.gov.br/rg/RBR-49zkm6	<NULL>	Health volunteers; both genders; aging between 8 and 24 years; molars with intact deep and retentive occlusal fissures to visual inspection; teeth in contact with the antagonist tooth; teeth presenting visual non-cavitated caries lesions located between the enamel and dentin junction and middle one-third of dentin.	Restorations and white spot lesions or cavitations on other tooth surfaces; teeth reported as sensitive to any type of stimulus; physically and mentally challenged volunteers; volunteers with systemic diseases under medication; children with poor oral habits affecting occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-45ywtg	Multiprofessional Program for Obesity Treatment in adolescents	Recruiting	Intervention	2016-02-19	<NULL>	<NULL>	716	Multidisciplinary Program for Obesity Treatment in Adolescents: efficacy trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Estadual de Maringá	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-45ywtg	<NULL>	Adolescents classified as overweight or obese according to the criteria established by Cole et. al (2000); concordance of the adolescent and his/her parents/guardians in participating integrally in the interventions.	The exclusion criteria will be: endocrine and metabolic diseases previously diagnosed and informed to the pediatrician; long-term alcohol consumption; use of glucocorticoids and psychotropics which could affect appetite regulation; less than 70 % compliance in all multidisciplinary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-9hcw2k	Pharmaceutical care in the basic health unit	Recruitment completed	Intervention	2016-02-22	<NULL>	<NULL>	717	Pharmaceutical care in primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9hcw2k	<NULL>	patients with metabolic syndrome; both genders; age above 18 years	pregnant women; people with cognitive difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-27kqv5	Comparison of a training videogame with conventional physiotherapy on postural control and quality of life of patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-25	<NULL>	<NULL>	718	Effects of physical therapy assisted by Kinect system in postural control, cognition and quality of life of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-14	Faculdade de Medicina da Universidade de São Paulo.	Faculdade de Medicina da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-27kqv5	<NULL>	Thirty-two participants will be selected between 50 and 80 years; diagnosed with idiopathic Parkinson&apos;s disease performed by specialized neurologists in extrapyramidal diseases according to the criterion of the Brains Bank of the UK Parkinson&apos;s Society; stages I to III of the Hoehn and Yahr scale; treated with levodopa and/or their synergists; do not present other neurological or orthopedic diseases diagnosed; do not present signs of dementia assessed using the Mini Mental State Examination with cutoff score according to educational level; with visual acuity and auditory normal or corrected; no prior experience with the Kinect system; have not participated in a rehabilitation program in the last two months and sign the Term of Consent of the study.	Patients will be excluded that during the period of the study present any clinical change that makes it impossible to perform physical exercises in standing position as cardiorespiratory; orthopedic or neurological disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-6bgqk4	Effects of two treatment techniques over the length and width step people with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-02-25	<NULL>	<NULL>	719	Effect of two differents intervention programs on kinematic parameters of gait in patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6bgqk4	<NULL>	will be included Male and female; with a diagnosis of idiopathic Parkinson&apos;s disease; classified in stages I to III of Hoehn Yahr; with the realization of independent walking without the use of assistive devices; which do not stage pharmacological adaptation; and can perform assessments and interventions &quot;on&quot; phase of medications for Parkinson&apos;s Disease.	Will be excluded those who experience pain; fracture; or serious injury to soft tissue in the six months previous history to the study and history of cardiovascular or respiratory changes uncontrolled and cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8qj4p5	Evaluation of blood pressure, blood flow fetal and neonatal outcome with the use of a phosphodiesterase type 5 inhibitor in the treatment of women with preeclampsia	Recruiting	Intervention	2016-02-26	<NULL>	<NULL>	720	Hemodynamics and perinatal assessment of phosphodiesterase type 5 inhibitors in pregnant women with preeclampsia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-8qj4p5	<NULL>	Pregnant women between 24-33 weeks. Diagnosis of pregnancy induced hypertension, defined as diastolic blood pressure equal to or greater than 90 mmHg and proteinuria above 0.3 g in 24 hours. Admitted at least 24 hours. Signing an informed consent form	Twin pregnancy. Diabetes. Provided hypertension and other chronic diseases. Serious fetal malformations. Fetal vitality of changes indicating the termination of pregnancy (reverse diastole umbilical artery, abnormal ductus venosus, severe oligoâminio, GMP below 6. Maternal changes indicating the termination of pregnancy (Eclampsia, HEELP syndrome, severe renal impairment). Patient use of magnesium sulfate, erythromycin, ketoconazole, itraconazole, or other antiretroviral drugs that have interaction with sildenafil. Refusal to sign the post informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5rh6cg	Benefits aquatic physical therapy in the trunk control in children with cerebral palsy	Recruitment completed	Intervention	2016-02-26	<NULL>	<NULL>	721	Aquatic physical therapy in the trunk control in children with cerebral palsy: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5rh6cg	<NULL>	Clinical diagnosis of spastic diparesis type of Cerebral Palsy; level IV to the Gross Motor Function Classification System (GMFCS); aged 4 years to 10 years and 11 months.	Uncooperative patients; unable to understand the proposed activities; undergoing orthopedic surgery or peripheral blocks less than 6 months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7d67hw	Restorations evaluation in primary teeth	Data analysis completed	Intervention	2016-02-26	<NULL>	<NULL>	722	Adhesive restorations in primary molars - a longitudinal clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-7d67hw	<NULL>	Patients aged 6 to 11 years; both genres; bearing teeth with active caries lesions limited to deep dentin / occluded proximal-occlusal surface of primary molars; absence of clinical diagnosis of pulp exposure, fistula, edema of the periodontal tissues and tooth mobility incompatible with stage of root resorption; absence of clinical symptoms of irreversible pulpitis; such as spontaneous pain or pressure sensitivity; the extent of the carious lesion should be such that complete / incomplete removal of decayed tissue not run the risk of pulp exposure as determined by clinical and radiographic evaluation; absence of radiolucencies in the inter-radicular regions (bifurcation) or periapical or thickening of the periodontal spaces which indicate the presence of irreversible pulp pathologies or necrosis; absence of internal or external root resorption.	Pulp exposure during cavity preparation procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-43sjz7	Benefits of physical therapy and cognitive training in the non-motor symptoms (sleep and cognition) in patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-26	<NULL>	<NULL>	723	Effectiveness of physical therapy associated to cognitive training in the improvement of non-motor symptoms in patients with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-43sjz7	<NULL>	"Medical diagnosis of Parkinson&apos;s disease, according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria)
Individuals over 50 years. Not  institutionalized. Mini Mental score that does not characterize cognitive impairment. Hohen Yahr between 1.5 and 3.0. Which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (CNS)."	Individuals who perform another therapeutic treatment beyond medication, that has change in medication during the study or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-6wvb5c	Effects of electrical stimulation of the quadriceps muscle strength and walking capacities in patients with chronic kidney disease on hemodialysis	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	724	Peripheral effects of electrical stimulation on peripheral muscle strength and exercise capacity in patients with chronic kidney disease on hemodialysis	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2015-08-11	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6wvb5c	<NULL>	Patients with CKD diagnostic who are on dialysis regularly for at least 6 months,  stable and under medical supervision; patients without: uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; patients without diseases that limit the electrical stimulation protocol (respiratory, orthopedic and / or neurological); patients who do not do any form of physical training or who have been held for more than six months.	Inability to perform any of the study assessments (lack of understanding or collaboration); recent decompensation of the clinical picture with or without hospitalization; presence of chronic obstructive pulmonary disease (COPD or emphysema), musculoskeletal diseases that impede the realization of assessments and training protocol, uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; abnormal sensitivity in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7q2n33	Effect of calcium intake on body weight and body fat in overweight individuals	Data analysis completed	Intervention	2016-03-01	<NULL>	<NULL>	725	Effect of calcium on weight and body composition in overweight individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Viçosa - UFV	Fundação do Amparo à Pesquisa do Estado de Minas Gerais - FAPEMIG	https://ensaiosclinicos.gov.br/rg/RBR-7q2n33	<NULL>	Healthy overweight or obese women; calcium intake less than 800 mg/day; physical activity level of mild to moderate; aged between 19 and 40 years; non smokers; restriction and disinhibition level less than 14.	Use of calcium or vitamin D supplements or any medication that affects the metabolism of calcium; medications or herbs for weight reduction; adoption of diets for weight reduction; use of drugs for estrogen replacement; weight gain or loss more tran 3kg in the last three months; recent changes in physical activity level; aversion or intolerance to foods used in the study; consumption of alcohol higher than 2 servings a day; presence of eating disorders, endocrine pathology, renal disfunction, hepatic disease or malabsorption syndrome; caffeine intake more than 350mg/day; pregnance; lactance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2zv39y	Contributions of Pray on the High Pressure, Heart Rate, Respiratory Rate and Anxiety of People With Kidney Disease in Dialysis Treatment	Recruitment completed	Intervention	2016-03-01	<NULL>	<NULL>	726	Contributions of Pray on Hypertension, Heart Rate, Respiratory and Anxiety of people with CRF undergoing Dialysis Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-20	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2zv39y	<NULL>	Having arterial hypertension 140 / 90 mmHg; high anxiety scores equal to or above 50; as the STAI instrument; take part in the study; to be clinically stable; oriented in time space and person; wish to receive the pray	Presence of deafness; presence limitations that compromise talks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5zpnnt	Effects of weight training program versus aerobic training on blood values, oxLDL and body weight individuals with metabolic abnormalities	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	727	Effects of a resistance training program periodized versus aerobic interval in functional parameters, lipid and oxLDL of individuals with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Ciências e Tecnologia	Faculdade de Ciências e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-5zpnnt	<NULL>	Having metabolic syndrome; not having practiced regular physical activity or have performed strength training in the last six months.	Make use of drugs or medicines; present amenorrhea; presence of inflammation and / or infection process; episode muscle tendon or osteoarticular lesions in the upper and lower limbs and / or spine; respiratory diseases, neurological and cardiovascular risk or high.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-39247h	Validation for the portuguese fatigue assessment questionnaire in patients with cancer: Cancer Fatigue Scale (CFS)	Not yet recruiting	Observational	2016-03-01	<NULL>	<NULL>	728	Brazilian version of the Cancer Fatigue Scale (CFS): study of the validity and reproducibility	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Paraná	Liga Paranaense de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-39247h	<NULL>	Physical therapy patients 18-65 years of age; in outpatient treatment for primary breast cancer; individuals with communication skills and understanding preserved.	Pregnant women will be excluded; patients with psychiatric disorders and / or neurological; patients with decompensated heart disease; patients with chronic lung disease; individuals unable to answer the evaluation questionnaires (such as illiterate and speech/writing disorders).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2jyhqp	Evaluating an intervention program to help parents raise their children	Recruitment completed	Intervention	2016-03-01	<NULL>	<NULL>	729	Evaluating the efficacy of a preventive intervention in parenting practices	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-30	Faculdade de Medicina de Ribeirão Preto - USP	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jyhqp	<NULL>	Mothers of children at 3 to 8 years of age, belonging to families living in Ribeirão Preto (SP), Brazil. The inclusion criteria are the following: biological mothers, adoptive mothers or caregivers with custody of the child carrying the maternal function (e.g., grandparents with custody of the child); residents in Ribeirão Preto.	mothers of children with mental illness or disabling physical illness; mothers with apparent cognitive impairment, leading to the loss in understanding instructions; and mothers who are participating in some other kind of guidance on parenting practices.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5cmtnk	Comparison between two techniques of pulmonary re-expansion in patients undergoing laparoscopic bariatric surgery.	Recruitment completed	Intervention	2016-03-01	<NULL>	<NULL>	730	Comparison between application of recruitment maneuver and manual chest compression and decompression in patients undergoing laparoscopic bariatric surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Universidade Estadual de Campinas	Fabiana Della Via	https://ensaiosclinicos.gov.br/rg/RBR-5cmtnk	<NULL>	Patients undergoing gastroplasty by laparoscopic; normal pulmonary function or mild disorders; no osteoarticular lesions (rib fractures or unstable thorax); those who agree to sign the Informed Consent Form.	Hemodynamic instability (Mean arterial pressure &lt;60 mmHg) at the time filed to perform alveolar recruitment maneuver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5sb8sb	Randomized clinical trial of three materials after partial caries removal in primary teeth	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	731	Randomized clinical trial of three pulp capping materials after partial caries removal in primary teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Odontologia de Bauru	Thais Marchini de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-5sb8sb	<NULL>	The sample inclusion criteria comprise children between 5-9 years old of both genders, that do not present systemic diseases; no allergic reaction history to the latex rubber dam and / or local anesthetic; with at least one or two primary molars (upper / lower) committed by deep decay that reaches two thirds of the dentin; occlusal and / or occlusal-proximal caries; with lack of sensitivity and / or spontaneous pain; absence of pulp exposure; absence of excessive mobility; absence of fistula or abscess; Radiographic absence of internal and external resorption; Radiographic absence of root resorption greater than 1/3 of the root; Radiographic absence of radiolucent image in the periapical region and furca that might indicate the presence of irreversible pulpitis or pulp necrosis; gum apparently healthy place; and tooth restorative possibility (BRESSANI et al, 2013;. Petrou et al, 2013;. SCHWENDICKE et al, 2015.).	Exclusion criteria comprise presence of systemic diseases; history of allergic reaction to the latex rubber dam and / or local anesthetic (BRESSANI et al, 2013;. SCHWENDICKE et al, 2015.).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-624vfv	Study of genetic alterations in patients with Keratoconus using DNA sequencing technique dna	Recruitment completed	Observational	2016-03-01	<NULL>	<NULL>	732	"Study of genetic mutations in patients with
Keratoconus in western central Brazil using reaction polymerase chain in real time"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Federal de Goias	Fundação Banco de Olhos	https://ensaiosclinicos.gov.br/rg/RBR-624vfv	<NULL>	Volunteers between 18-40 years of age with keratoconus; without keratoconus; no surgery or previous eye diseases; absence of systemic diseases; who accept sign the consent form and clarification	volunteers under the age of 18 years and above 40 years; who did not accept to sign the consent form and enlightenment; with diseases or previous eye surgery; systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-9p3hdp	Resin restorations assessment made ??by applying differently the adhesive system	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	733	Adhesion of composite resin direct restorations with different protocols of adhesive system application – a clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-16	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9p3hdp	<NULL>	Age between 18 and 60 years; both genders; need for Class I and II restorations in premolars and/or molars, presence of at least three dental elements to be restored whose antagonist teeth are present; presence of at least 20 teeth in occlusion.	Holders or removable orthodontic appliances; holders of bruxism; pregnant or breast-feeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-8xg8g8	Evaluation of Mastication and Bite force in complete denture wearers	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	734	Influence of Occlusion guidance and Mandibular ridge resorption on Masticatory performance and Ability, and Maximum occlusal force in complete denture wearers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-05	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-8xg8g8	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years, of both genders; users or non-conventional complete dentures; requiring preparation or replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-27sdv5	Anti-human globulin Rh D drug from effectiveness from review after vaccination in women with postpartum negative factor blood and with complications risk in newborns	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	735	Evaluation of clinical efficacy of Kamrho-D® drug (anti-human globulin Rh D - Panamerican) in postpartum women Rh negative immunization, coombs indirect negative and sensitization risk	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-02-01	Hospital São Lucas da PUC/RS (Centro Coordenador)	LAL Clinica Pesquisa e Desenvolvimento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-27sdv5	<NULL>	"Postpartum women who agreed to participate and sign and date back to the Informed Consent (IC);
Postpartum women over the age of 18;
negative Rh postpartum women, Coombs negative indirect analyzed by gel agglutination method, whose newborn is Rh +."	"Simultaneously be participating or have participated in another clinical study within the last 12 months;
postpartum women allergy sufferers to any of the components of the formula;
postpartum women with IgA deficiency history or story to IgA antibody;
postpartum women with a history of autoimmune hemolytic anemia with pre-existing risk with hemolysis or hemolysis;
postpartum women who have positive Indirect Coombs test at the beginning of treatment;
postpartum women who have given birth to negative Rh fetuses;
postpartum women with abnormalities of the coagulation system;
Patients who used elaborate vaccines with live pathogens in the last 03 months or will do during the study;
Patients with pre-natal clinical diagnosis of liver disease and / or severe nephropathy.
At the discretion of the Principal Investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5bb65v	Rating of ventilation with two pressure levels when the patient exhales in patients with severe inflammatory disease in the lung.	Recruiting	Intervention	2016-03-03	<NULL>	<NULL>	736	Short-term effects of mechanical ventilation with two levels of PEEP (BiPEEP) in patients with Acute Respiratory Distress Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Centro Universitário Metodista - IPA	Complexo Hospitalar Santa Casa de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5bb65v	<NULL>	Mechanically ventilated patients for more than 24 hours; presenting hemodynamically stable (mean arterial pressure between 70 and 120 mm Hg); PaO 2 / FiO 2 100-300; diffuse infiltrates on chest radiograph.	Patients with a history of pulmonary emphysema; presence of barotrauma; chest tube; undrained pneumothorax.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-6n3dzz	Exercise and ventilatory support in patients with Chronic Obstructive Pulmonary Disease after inspiratory muscle training	Recruiting	Intervention	2016-03-04	<NULL>	<NULL>	737	Endurance associated with noninvasive ventilation in patients with chronic obstructive pulmonary disease after inspiratory muscle training	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-13	Fundação Universidade Federal de Mato Grosso do Sul	Hospital Universitario Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6n3dzz	<NULL>	Patients of both sexes; aged between 40 and 80 years diagnosed with Chronic Obstructive Pulmonary Disease Class III and IV (severe to very severe) according to the Global Initiative for Obstructive Lung Disease criteria (GOLD). Exacerbation free in the 4 weeks prior to testing; absence of cardiovascular disease; arthritis; asthma; pulmonary hypertension; diabetes or musculoskeletal disorders that prevent the achievement of exercise tests.	Patients younger than 40 and older than 80 years who present cardiovascular changes during the exercise test. Those who do not attend at least 80% of the stages of inspiratory muscle training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-8ngpq9	Effect of coconut and olive oil in energy expenditure in overweight women	Recruitment completed	Intervention	2016-03-04	<NULL>	<NULL>	738	Acute effect of coconut and olive oil on postmeal thermogenesis and oxidation rate of substrates in overweight women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-20	Universidade Federal de Viçosa - UFV	Universidade Federal de Viçosa - UFV	https://ensaiosclinicos.gov.br/rg/RBR-8ngpq9	<NULL>	Fifteen women will be select to participate in the study; 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day.	chronic diseases; weight and physical activity maintenance; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-78qtwy	Effects of treadmill physical exercise in women with polycystic ovaries	Recruiting	Intervention	2016-03-07	<NULL>	<NULL>	739	Effects of continuos and interval aerobic physical training  in women with polycystic ovary syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-11	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-78qtwy	<NULL>	Volunteers with PCOS between 18 to 39 years old; body mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II); Do not practice regular physical activity.	Presence of systemic disease that contraindicate to physical activity; presence of disabling musculo-skeletal disorders; use of drugs that interfere with the hypothalamic-pituitary-ovarian-axis and hormonal contraceptives; smoking, pregnant and volunteers who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7cfctd	Acupuncture in pain and quality of life of women with irregular menstruation	Recruitment completed	Intervention	2016-03-07	<NULL>	<NULL>	740	Acupuncture in clinical manifestations of Endometriosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	UDESC- Universidade do Estado de Santa Catarina	HU- SC Hospital Universitário Professor Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-7cfctd	<NULL>	"The sample provides 42 women aged between 18 and 45 years; with endometriosis; who have signs and symptoms such as pelvic pain; dyspareunia; and deficits in quality of life for at least 1 year.
As are 21 women in the experimental group and 21 in the control group the total sample will include 42 women."	Fear of needles; use of anti-inflammatory or analgesic; physical therapy for pelvic floor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2j7hbf	Effects of a shoulder joint strengthening program on muscular balance and throwing	Data analysis completed	Intervention	2016-03-08	<NULL>	<NULL>	741	Effect of shoulder external rotator eccentric strengthening program on strength balance and on throwing speed and accuracy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2j7hbf	<NULL>	Female handball atlhetes volunteers; attended at least one full competitive season; without upper limb injury for at least six months	Volunteers feeling pain; swelling; inability to perform physical exercises; symptomatic or asymptomatic orthopedic injuries associated with upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7qnsh6	Pilates training effects on physical aspects and quality of life in overweight or obese people	Data analysis completed	Intervention	2016-03-08	<NULL>	<NULL>	742	Pilates training effects on physiological responses, health parameters and quality of life in overweight or obese people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qnsh6	<NULL>	BMI higher than 25 kg/m2; total body mass maximal of 120kg; at least six months without practicing any kind of physical activity.	History of neurological; cognitive; orthopedic; respiratory; or endocrine disease (except obesity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-7gb4wm	Evaluation of the educational activities in Diabetes in Primary Health Care	Data analysis completed	Intervention	2016-03-09	<NULL>	<NULL>	743	Evaluation of the model of educational activities in Diabetes Mellitus Type 2 in Primary Health Care Units	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7gb4wm	<NULL>	Patients who are diagnosed with Diabetes mellitus type 2; both sexes; age between 30 and 80 years; with access to fixed or mobile phone line.	Patients who are diagnosed  with chronic complications such as diabetic retinopathy; diabetic neuropathy; diabetic nephropathy and amputation. Patients who do not attend  the call for more than five consecutive attempts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4hm9bf	A clinical trial investigating the anti-virus effects, kinetics and safety of GS-5806 in adults with RSV (respiratory syncytial virus) infection	Not yet recruiting	Intervention	2016-03-10	<NULL>	<NULL>	744	A phase 2b, randomized, double-blind, placebo controlled multi-center study evaluating antiviral effects, pharmacokinetics, safety, and tolerability of GS-5806 in hematopoietic cell transplant (HCT) recipients with respiratory syncytial virus (RSV) infection of the upper respiratory tract	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-07-01	Fundação Doutor Amaral Carvalho	Pharmaceutical Research Associates Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4hm9bf	<NULL>	Received an autologous or allogeneic hematopoietic cell transplantation (HCT) using any conditioning regimen; Documented to be RSV-positive (respiratory syncytial virus) as determined by local testing for example, PCR (polymerase chain reaction), DFA (direct fluorescent antibody), RVP (respiratory virus pannel) assay, or culture using an upper respiratory tract sample collected 6 days or less prior to Day 1; New onset of at least 1 of the following respiratory symptoms for 7 days or less prior to Day 1: nasal congestion, runny nose, cough, or sore throat, or worsening of one of these chronic respiratory symptoms 7 days or less prior to Day 1; No evidence of new abnormalities consistent with LRTI on a chest X-ray relative to the most recent chest X-ray, as determined by the local radiologist. If a chest X-ray is not available or was not obtained during standard care 48 hours or less prior to Screening, a chest X-ray must be obtained for Screening; O2 saturation equal or higher than 92% on room air; An informed consent document signed and dated by the subject or a legal guardian of the subject and the investigator or his or her designee; A negative urine or serum pregnancy test is required for female subjects, unless surgically sterile or greater than two years post-menopausal; Male and female subjects of childbearing potential must agree to contraceptive requirements as described in Appendix 5; Willingness to complete necessary study procedures and have available a working telephone or email.	Related to concomitant or previous medication use: Use of non-marketed according to region investigational agents within 30 days, OR use of any monoclonal anti-RSV antibodies within 4 months or 5 half-lives of Screening, whicheveris longer, OR use of any investigational RSV vaccines after HCT; Use of a strong cytochrome P450 enzyme inducer including but not limited to rifampin, St. John’s Wort, carbamazepine, and phenytoin, within 2 weeks prior to the first dose of IMP; Related to medical history: Admitted to the hospital primarily for a lower respiratory tract disease of any cause as determined by the investigator; Pregnant, reastfeeding, or lactating females; Unable to tolerate nasal sampling required for this study, as determined by the investigator; Known history of HIV and or AIDS with a CD4 count &lt;200 cells/microL within the last month; History of drug and/or alcohol abuse that, in the opinion of the investigator, may prevent adherence to study activities; Related to medical condition at Screening: A relapse, including molecular relapse, of the underlying disease for which they received a transplant at Screening; Documented to be positive for other respiratory viruses limited to influenza, parainfluenza, human rhinovirus, adenovirus, or human metapneumovirus within 7 days prior to the Screening visit, as determined by local testing; Clinically significant bacteremia or fungemia within 7 days prior to Screening that has not been adequately treated, as determined by the investigator; Clinically significant bacterial, fungal, or viral pneumonia within 2 weeks prior to Screening that has not been adequately treated, as determined by the investigator; Excessive nausea/vomiting at Screening, as determined by the investigator, or an inability to swallow pills that precludes oral administration of the IMP; Any condition which, in the opinion of the investigator, would prevent full participation in this trial or would interfere with the evaluation of the trial endpoints; Related to allergies: Known hypersensitivity or allergy to the IMP, its metabolites, or formulation excipients like microcrystalline cellulose, mannitol, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol and talc; Allergy to sulfa drugs; Related to laboratory results: Creatinine clearance lesser than 30 mL/min, calculated using the Cockcroft-Gault method; AST/ALT higher than 3x ULN; Total bilirubin higher than 3x ULN.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-2xcd99	Gastrointestinal and lung cancer, effects of the fish oil intake on nutritional status, quality of life and imunnometabolic outcomes	Recruiting	Intervention	2016-03-10	<NULL>	<NULL>	745	Gastrointestinal and lung cancer, effects of the fish oil intake on nutritional status, quality of life and imunnometabolic outcomes	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-02	Universidade Federal de Santa Catarina - UFSC	Centro de Pesquisas Oncológicas de Florianópolis - CEPON/SC	https://ensaiosclinicos.gov.br/rg/RBR-2xcd99	<NULL>	Individuals with 19 years or older, histopathologic diagnosis of gastric cancer, or colorectal or anal canal or non-small cell lung cancer, ability to start chemotherapy in co-participant institution (CEPON).	"Prior chemotherapy, inability to
oral intake, diagnosis of infectious or inflammatory disease, be allergic to fish and / or derivatives, be pregnant, treatment with statins, ??use of fish oil and/or another supplement containing omega-3 or other polyunsaturated fatty acid in the six months
prior to the study period, continued use of supplements containing antioxidants."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-6pmfz8	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	746	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent GBTLI ALL-2009	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-01-01	Sociedade Brasileira de Oncologia Pediátrica (SOBOPE)	Centro Infantil Boldrini (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-6pmfz8	<NULL>	"Will be eligible for this study all patients aged &lt; 18 years (up to 17.99 years ) diagnosed with previously untreated ALL, with emphasis on no steroid use.
The requisites for proper leukemia diagnostic profile are: cytomorphological analysis, cytochemistry, immunephenotyping spinal fluid profile, cytogenetics and molecular biology
All patients and their legal representatives should be informed about the investigative nature of this study and must sign and provide free and informed consent in accordance with institutional and federal recommendations."	"Without Informed Consent Term.
ALL patient aged &gt; 18 years.
Prior use of corticosteroids.
Not confirmed the ALL diagnosis, after Central review."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-7dp6hs	Effects of three different strength training on mass and muscle strength.	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	747	Effects of isometric, isotonic or isokinetic training on mass and muscle strength.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dp6hs	<NULL>	Age between 18 and 30; male; no history of knee or thigh injury in the past five years; had not undertaken any leg strength training during the previous six months.	Pain; swelling; inability to do exercises; asymptomatic orthopedic injuries or other pathology that  limits the realization of maximum torque with the lower limbs; female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-93gkd4	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as single therapy for patients with newly diagnosed partial-onset seizures - ESL extension study	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	748	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as monotherapy for patients with newly diagnosed partial-onset seizures: a double-blind, randomized, active-controlled, parallel-group, multicenter clinical trial - open-label ESL extension	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2016-01-04	Instituto de Neurologia de Curitiba	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-93gkd4	<NULL>	Participation in the preceding double-blind study and still ongoing at the time of unblinding; informed consent signature; cooperation and willingness to complete all aspects of the study.	Exclusion from the double-blind study; clinical evaluation of suicidal risk; occurrence of an adverse event; events of alcohol, drug, or medication abuse; relevant clinical laboratory abnormalities; pregnancy or lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-9tphvs	Role of neuromotor training nn gait pattern and mobility of ankles in elderly	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	749	Role of neuromotor training nn gait pattern and mobility of ankles in elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-03	Universidade do Contestado	Universidade do Contestado	https://ensaiosclinicos.gov.br/rg/RBR-9tphvs	<NULL>	gender female,65 to 75 years old,practicing of regular physical activity,sedentary	physical disability;auxiliary device of march;neurological disorders with sequels;severe visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-9n97k2	Green tea &apos;s effect on renal function in patients with kidney disease due to diabetes	Recruitment completed	Intervention	2016-03-14	<NULL>	<NULL>	750	Effect of green tea extract on biomarkers of renal function in patients with Diabetic Nephropathy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-20	Faculdade de Nutrição da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9n97k2	<NULL>	"Diabetes mellitus diagnosis for at least five years; be aged between 20 and 59anos ;
present albuminuria values between 30 - 300 mg or proteinuria between 150 - 500mg."	Urinary tract infection; cardiac decompensation; hyperthyroidism ; fever for at least three days; liver disease ; menopausal women and hormone treatment ; pregnant and lactating women .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-6srs33	Use a flipchart to promote the mother&apos;s confidence in breastfeeding her child	Data analysis completed	Intervention	2016-03-14	<NULL>	<NULL>	751	Using a flip chart for the promotion of maternal self-efficacy in nursing	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Universidade Federal do Ceará	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6srs33	<NULL>	Women in the immediate postpartum period and after six hours of birth; with 12 or more years of age; mothers admitted to the rooming together with the newborn with good vitality, effective suction capacity and thermal control.	Women who showed clinical complications at the time of data collection; obstetric complications in the postpartum period; mothers with some difficulty understanding and verbal expression that prevented her from participating in the educational intervention or respond to the instruments; maternal infectious condition which prevented or contraindicated breastfeeding; mothers admitted to the rooming with children in the Neonatal Intensive Care Unit; and newborns of mothers who showed abnormalities that precluded or made it difficult breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-27g66s	Use of diabetes medication to prevent diabetes during pregnancy	Recruiting	Intervention	2016-03-15	<NULL>	<NULL>	752	Prophylactic use of Metformin in Gestational Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-31	Universidade da Região de Joinville - Univille	Hospital Regional Hans Dieter Schmidt Secretaria do Estado de Saúde de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-27g66s	<NULL>	Pregnant women will be diagnosed with GDM selected according to the criteria of the World Health Organization; aged over 18 years; singleton pregnancy; with screening for gestational diabetes mellitus (GDM) in early positive pregnancy; gestational age between 11 and 33 weeks; no pathology that interferes with glucose metabolism; no hypersensitivity to metformin hydrochloride or important drug allergy; history or presence of liver disease; renal or gastrointestinal or other conditions that interfere with absorption; distribution; excretion or metabolism of the drug.	They will be excluded from follow-up losses; intolerance to drugs; desire of the mother and presence of risk to the fetus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-44kg5x	Intralesional treatment for cutaneous leishmanisis	Recruiting	Intervention	2016-03-16	<NULL>	<NULL>	753	Efficacy and safety of intralesional use of meglumine antimoniate in the treatment of localized cutaneous leishmaniasis	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2015-08-03	Hospital Eduardo de Menezes	Centro de Pesquisa Rene Rachou, Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-44kg5x	<NULL>	volunteers with localized cutaneous form of leishmaniasis; both sexes; with up to maximum of three lesions and area of lesions of not more than 900mm2	"Pretreatment with antileishmanial drugs for less than 6 months;
History of allergy to meglumine antimoniate; Presence of congestive heart failure or cardiac arrhythmia; Medication with potential to cause cardiac arrhythmia; Pregnancy or lactation; Creatinine above 2 mg%"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-5qkck4	Transcutaneous electrical nerve stimulation and diathermy microwave effects in the menstrual cramps	Not yet recruiting	Intervention	2016-03-16	<NULL>	<NULL>	754	Transcutaneous electrical nerve stimulation and diathermy microwave effects in the primary dysmenorrhea: placebo-controlled clinical trail	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Cidade de São Paulo	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5qkck4	<NULL>	Health women; 18 to 44 years; no previous pregnancy; no physical activity; body mass index &lt;29.9 kg/m²; and had regular menstrual cycles, mild to moderate or severe menstrual cramps.	"hormonal contraceptives use; anti-inflammatory and/or analgesics for the treatment of menstrual cramps or any dysfunction;
diabetes; rheumatic arthritis; gynecological diseases; presence of malignant or benign tumor; metal implants; cardiac diseases; pacemaker use; decreased or absence of sensitivity in the abdominal region; and epilepsy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-8kvgy3	Effects of balance training associated with cardiorespiratory training in the water about the falls risk and funcionality in women	Data analysis completed	Intervention	2016-03-16	<NULL>	<NULL>	755	Therapeutic approach in the quality of life and elderly functionality	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Pontificia Universidade Católica de Goiás	Adriana Marcia Monteiro Fantinati	https://ensaiosclinicos.gov.br/rg/RBR-8kvgy3	<NULL>	Women over 45 years old, participants of UNATI (Universidade Aberta à Terceira Idade) PUC - GO (Pontificia Universidade Católica - Goiás), capable according with the Mini Mental State Examination (MMSE) with score minimum of 17, considering illiterate , 75% presence in cardiorespiratory training in the water and in balance training in solo for a period of three months , who participated in all assessments proposed in the study and signed the Informed Consent and Informed.	Women who did not pass in the screening UNATI (Universidade Aberta a Terceira Idade) PUC - GO (Pontifícia Universidade Católica - Goiás) prior to attending the program, did not participate in Six Minutes Walk Test (6MWT) due the following contraindications: recent electrocardiographic changes; recent myocardial infarction acute ; high resting blood pressure (systolic bigger then 180 mmHg; diastolic bigger then 100 mmHg); unstable angina during the last month; heart rate greater than 120 beats per minute.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-9x3d52	Acute effect on the strength of exercise with different loads and muscle mass recruited in cardiovascular variables: blood pressure, heart rate, rate-pressure product and post-exercise hypotension in healthy women and active	Recruitment completed	Intervention	2016-03-16	<NULL>	<NULL>	756	Acute effect of resistance exercise of different intensities and recruited muscle mass in hemodynamic variables: blood pressure, heart rate, rate-pressure product and post-exercise hypotension in active normotensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto de Educação Física e Esportes - Universidade Federal do Ceará	Instituto de Educação Física e Esportes - Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9x3d52	<NULL>	Healthy normotensive women; aged between 18 and 30 years; with minimum experience of 8 months in resistance training; has no personal history of cardiovascular disease; in continuous training in ER of at least four months.	Known cardiovascular disease; arterial hypertension; smoking; diagnosed osteoporosis; musculoskeletal problems that prevent or restrict the realization of the leg-press exercise 45; make use of any medication or drugs that stimulate the cardiovascular system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-396q4g	The use of a strategy to teach the bed bath	Recruitment completed	Intervention	2016-03-18	<NULL>	<NULL>	757	The simulations of use in bath education in bed	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-396q4g	<NULL>	Be enrolled and studying the semiotics of discipline of the 5th graduation period in Nursing	Be technical or auxiliary nursing; have previously performed the bathing care in bed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4d6n9r	Analysis of genetic information from men with and without varicocele	Not yet recruiting	Observational	2016-03-18	<NULL>	<NULL>	758	Sperm transcriptome profile in men with and without varicocele	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Medicina de Ribeirão Preto	Centro Regional de Hemoterapia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4d6n9r	<NULL>	"Study group: men that have varicocele in grades II and III; aged between 18 and 45 years; not having done previous surgery correction of the disease.
Control groups: men aged between 18 and 45 years; fertility proven by having at least two children; and selected men from couples with infertility for male factor or unexplained infertility."	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4rcsc6	Strength evaluation after  open surgery for bladder in patients undergoing conventional fasting and fasting with limited time	Data analysis completed	Intervention	2016-03-18	<NULL>	<NULL>	759	Functional assessment after open cholecystectomy in patients undergoing conventional and abbreviated fasting	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-12-05	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4rcsc6	<NULL>	adult female patients, aged 18 to 60 years old undergoing open cholecystectomy	Younger than 18 years and greater than 60 years, male, other diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-48z8pv	Evaluation of performance motor in infants at risk	Recruitment completed	Intervention	2016-02-26	<NULL>	<NULL>	760	Evaluation of performance motor in infants at risk	<NULL>	0, single-arm-study, open	0	<NULL>	<NULL>	<NULL>	2015-02-05	Universidade Federal do Ceará	Kátia Virginia Viana Cardoso	https://ensaiosclinicos.gov.br/rg/RBR-48z8pv	<NULL>	Submit medical records at the clinic of the MEAC, is not participating in intervention programs.	Joint and muscle conditions and infections with fever.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-42c8wp	Complementary Therapies for stress and anxiety reduction and improving quality of life	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	761	"Applicability of Complementary Therapies for pain, stress, anxiety reduction
and improving quality of life: Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-42c8wp	<NULL>	Inclusion Criteria: The patients with  medium and high level of stress score on the Stress Symptoms List (LSS)	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressant or other energy therapies to manage stress and anxiety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-55mp5z	Comparison of two drugs to prevent nausea and vomiting after surgery for reducing the stomach	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	762	Palonosetron versus ondansetron for postoperative nausea and vomiting prophylaxis in laparoscopic gastroplasty in morbid obese patients - a randomized controlled noninferiority trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-11-15	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-55mp5z	<NULL>	Adult patients undergoing elective laparoscopic gastroplasty; both sexes; 20 to 65 years old; physical state I and II according to American Society of Anesthesiology (ASA); body mass index equal or higher than 35 kg/m2	Use of antiemetics for 48 hs before surgery; those with hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4982b5	Hydrotherapy in low back pain	Data analysis completed	Intervention	2016-03-18	<NULL>	<NULL>	763	Effects of an abdominal progression protocol hydrotherapy in women with low back pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Fisioterapia da Universidade Católica de Pelotas	Faculdade de Fisioterapia da Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4982b5	<NULL>	Female patients; patients who experience pain in the lower back for at least three months; between the ages of 35 and 55 years.	Patients who have received physical therapy for low back pain in the last two months; patients in pregnancy ; hypertensive patients not controlled ; infectious diseases; genetic disorders ; oncological diseases , neurological diseases ; cognitive changes that do not understand verbal commands ; Phobia water; urinary or fecal incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-7tm6h5	Teaching critical thinking for undergraduate nursing students: an educational intervention	Recruitment completed	Intervention	2016-03-23	<NULL>	<NULL>	764	Teaching Critical Thinking  for nursing students: a randomized controlled pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Escola de Enfermagem da Universidade de São Paulo	Fábio da Costa Carbogim	https://ensaiosclinicos.gov.br/rg/RBR-7tm6h5	<NULL>	"The selection of students for participation in the course will be subject to prior disclosure with 30 days in advance, through posters and communication in classrooms by the researcher, with guidelines for the application process.
May participate students from first to seventh period of the course (did not have first aid content).
 For selection and availability of vacancies, disclosure was made for a total of 260 students. 104 subscribers will be informed and enlightened about the research and participate after signing the Informed Consent and Informed (IC).
The allocation of classes, control and experiment, occur randomly by randomization. We will use statistical software R (version 3.0.2) to give away 52 individuals from the total of 104 study participants to compose the experimental group, keeping the ratio of men and women and among individuals with less or more than 22 years in the experimental groups and control. Using the sample function and the pseudo random algorithm Marsenne-twister, the subjects were assigned to one group or the other."	"Students who are not enrolled in the course; Students of the eighth, ninth and tenth period of graduation; 
Students who do not appear on the dates specified for the course (100% attendance)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-74jbmn	Effect of an oral health promotion intervention in primary health care	Recruiting	Intervention	2016-03-28	<NULL>	<NULL>	765	Implementation and evaluation of an oral health promotion intervention for children aged zero to five years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-74jbmn	<NULL>	It will be included Primary Health Care Centers belonging to the urban area, that have family oral health team working for at least one year, at least 200 children from zero to five years old enrolled, offering postpartum care and childcare. All children enrolled in Primary Health Care Centers aged between 0 and 3 years old will be eligible to participate.	Primary Health Care Centers that are holding other interventions in oral or nutritional health, which have different work process will be excluded. It will be excluded children whose families wish to move in within six months of the baseline study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3q2sdt	A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis	Recruiting	Intervention	2016-03-29	<NULL>	<NULL>	766	CNTO1275AKS3002 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Subjects With Active Radiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-18	LMK Serviços Médicos SS	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q2sdt	<NULL>	Inclusion Criteria: Participants must have a diagnosis of definite ankylosing spondylitis (AS), as defined by the modified 1984 New York criteria. The radiographic criterion must be confirmed by a central xray reader and at least 1 clinical criterion must be met; Participants must have symptoms of active disease at screening and at baseline, as evidenced by both a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of greater than or equal to (&gt;=4) and a visual analog scale (VAS) score for total back pain of &gt;=4, each on a scale of 0 to 10; Participants with elevated high sensitivity C-reactive protein (hsCRP) level of &gt;=0.300 milligram per deciliter (mg/dL) at screening - Refractory by either lack of benefit or documented intolerance to 1 and no more than 1 anti-TNF(alpha) agent; Inadequate response to at least 2 nonsteroidal anti-inflammatory drugs (NSAIDs) over a 4-week period in total with maximal doses of NSAID(s), or is unable to receive a full 4 weeks of maximal NSAID therapy because of intolerance, toxicity, or contraindications to NSAIDs.; Participants with complete ankylosis of the spine are permitted to be included in the study, but will be limited to approximately 10 percent (%) of the study population	Exclusion Criteria: Participants who have other inflammatory diseases that might confound the evaluations of benefit from the ustekinumab therapy, including but not limited to, rheumatoid arthritis, systemic lupus erythematosus, or Lyme disease - Participants who have received infliximab or infliximab biosimilar, within 12 weeks of the first study agent administration; have received adalimumab, adalimumab biosimilar, or certolizumab pegol within 6 weeks of the first study agent administration; have received etanercept or etanercept biosimilar within 6 weeks of the first study agent administration;  Participants who have ever received golimumab ; Participants who are pregnant, nursing, or planning a pregnancy or fathering a child while enrolled in the study or within 5 months after receiving the last administration of study agent; Participants who have received any systemic immunosuppressives or disease-modifying antirheumatic drugs (DMARDs) other than methotrexate (MTX), sulfasalazine (SSZ), or hydroxychloroquine (HCQ) within 4 weeks prior to first administration of study agent. Medications in these categories include, but are not limited to leflunomide, chloroquine, azathioprine, cyclosporine, mycophenolate mofetil, gold, and penicillamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3h6n6c	Acidity effect of whitening gel on the effectiveness and sensitivity of teeth after in office bleaching	Recruitment completed	Intervention	2016-03-30	<NULL>	<NULL>	767	Effect of pH of the bleaching gel in the effectiveness and tooth sensitivity after in office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Centro de Ensino Superior dos Campos Gerais - CESCAGE	Centro de Ensino Superior dos Campos Gerais - CESCAGE	https://ensaiosclinicos.gov.br/rg/RBR-3h6n6c	<NULL>	Patients will be included in this clinical trial were men and women; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade A2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4m94g4	Neurosensory analysis of tooth sensitivity during at-home dental bleaching	Data analysis completed	Intervention	2016-03-30	<NULL>	<NULL>	768	Influence of the cold sensation threshold on the occurrence of dental sensitivity before dental bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Faculdade de Odontologia de Araçatuba - Unesp	Faculdade de Odontologia de Araçatuba - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-4m94g4	<NULL>	Volunteers with healthy and vital maxillary teeth; no decayed teeth; no visible enamel defects; no orthodontic brackets; overall good systemic health; healthy oral soft tissue; non-smoking; pacients who have never undergone bleaching treatment.	Direct and indirect restorations in the maxillary anterior region; adverse reaction to peroxide; use of opioids or medications influencing neurosensory response; use of pacemaker; presence of severe dental staining (tetracycline, trauma, fluorosis, and unknown etiology); neurological diseases; chronic or acute diseases; dentine exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3dccf6	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Avoiding in Adult Participants With Treatment-resistant
Depression"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	769	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant
Depression"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-07-09	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3dccf6	<NULL>	Inclusion Criteria: At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current  episode of depression - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment For Transferred-Entry Participants - The participant must have completed the double-blind induction phase in ESKETINTRD3001 or ESKETINTRD3002 and must have demonstrated response at the end of that phase (&gt;=50% reduction in the MADRS total score from baseline [Day 1 pre-randomization] at the end of the 4-week double-blind induction phase)	Exclusion Criteria: - Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT – Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (CSSRS) - Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-5vkxts	A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	770	An Open-label, Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-07-23	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5vkxts	<NULL>	Research participants with direct Entry: The study population will include men and women with 18 years of age who meet the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for recurrent MDD or MDD single episode ( a single episode, the episode duration should be 2 years) without psychotic features, based on clinical evaluation and confirmed by Mini International Neuropsychiatric Interview (MINI). In screening, the research participant must have a MADRS total score 22, which corresponds to at least moderate depression .Research participants with direct entry will be eligible for screening regardless of whether they are taking or not currently oral antidepressant medications. In screening, the research participants with direct entry must habe no response to two different oral antidepressant treatments administered in proper dosage and proper duration (including oral antidepressant currently taken, if applicable), as measured in MGH-ATRQ and documented by history medical and / or pharmacy records / prescription for the current episode .Research participants  with transfer entry. All survey participants with transfer entry (elderly research participants with 65 years of age) who completed the double-phase induction blind ESKETINTRD3005 study will be eligible for this study: nonresponders research participants will join the study at the beginning of the open induction phase; responders research participants will join the study from the beginning of the optimization/maintenance phase.	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode or all of the oral antidepressant treatment available in their country in the open induction phase (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) in the current major depressive episode (based on MGH-ATRQ). Research participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, intellectual disability (DSM-5 diagnostic codes 317 , 318.0, 318.1, 318.2, 315.8 and 319), autistic spectrum disorder, borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / homicidal or suicidal ideation intent with any intention to act within 6 months before the screening phase according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia ( CSSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5. Furthermore, study participants with 65 ages will be excluded if they have neurodegenerative disorders (eg., Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI) or a score of the Mini Mental State Examination ( MMSE) 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3xk32h	A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants with Treatment-resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	771	A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy,  Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly  Subjects with Treatment-resistant Depression	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-24	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3xk32h	<NULL>	Study population will include older men and women, 65 years of age (inclusive) and above, meeting the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for single episode of MDD (if MDD single episode, the duration shall be 2 years) or MDD recurrent without psychotic features, based on clinical assessment and confirmed by the International Mini Neuropsychiatric Interview (MINI). In addition, the research participant must have a total score of Inventory Symptomatology Depressiva Evaluated by Medical 30 items (IDS-C30) of 34, which corresponds to moderate depression severa.No early screening / prospective observational phase, research participants should be submitted no response to 2, but 5, oral antidepressant treatments administered at an appropriate dose and a suitable duration, as assessed using the response Questionnaire Treatment antidepressant - Massachusetts General Hospital (MGH-ATRQ) and documented by medical history and pharmacy records / prescription for the current episode of depression. At the start of screening / prospective observational phase, the research participant must be one of those currently taking antidepressant treatments with non-major depressive episode documentada.O response current research participant and the treatment response to antidepressant treatments used in the present depressive episode ( assessed retrospectively) should be considered valid for participation in a clinical trial based on a Qualification Assessment Centre Independent. The Qualification Assessment Centre Independent is a tool to facilitate the selection of research participants for clinical studies of MDD, with a goal to ensure the inclusion of research participants that reflect the current state of disease, and that these symptoms can be measured reliably with appropriate measuring tools	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode, all four options oral antidepressant treatment available for the phase double-blind induction (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) a larger current depressive episode (based on MGHATRQ), or an appropriate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT. Research participants who currently have an implant to vagal nerve stimulation (VNS) or who received deep brain stimulation (DBS) in this major depressive episode will be deleted. Survey participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, neurodegenerative disorder (eg., Disease Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI), a score of the Mini-Mental State Examination (MMSE) &lt;25, STOP-Bang questionnaire score of 5, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / intent homicidal or suicidal ideation with any intention to act within 6 months before the start of the phase of screening / prospective observational according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia (C-SSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2pk58p	"An Efficacy and Safety Study of Ustekinumab in Participants With Active Nonradiographic Axial
Spondyloarthritis"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	772	CNTO1275AKS3003 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Subjects With Active Nonradiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-06-30	CPCLIN - CENTRO DE PESQUISAS CLINICAS LTDA	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-2pk58p	<NULL>	Research participants should be between 18 and 50 years of age.Rresearch participants should be classified as having NR AxSpA, based on the ASAS criteria 2009.Must present diagnostic nr-AxSpA, according to the criteria of 2009 ASAS, for 5 years.Must be 45 years old at onset of nr-AxSpA .In selection or within 3 months of selection, research participants are to present active inflammation on MRI highly suggestive of sacroiliitis associated with spondyloarthritis and should not present radiographic sacroiliitis that meets the 1984 (New York criteria modified as confirmed by an X-ray rated by central readers ) .Must present symptoms of active disease at screening and at baseline, as evidenced by both BASDAI score 4 as by a score of VAS 4 of total back pain, each on a scale of 0 to 10.Must present an inadequate response to at least two NSAIDs over a period of 4 weeks, in total, with the maximum doses recommended NSAID (s) or be unable to receive a full period of 4 weeks of treatment with most NSAIDs because of intolerance, toxicity or contraindications for NSAIDs.Research participants previously treated with an anti-TNF biologic agent must be: primary or secondary responders to at most one anti-TNF agent or intolerance present documented maximum one anti-TNF treatment or have discontinued at most 1 anti-TNF agent due to lack of efficacy / safety .IF are using other NSAIDs or analgesics for nr-AxSpA, research participants should be receiving a stable dose for at least 2 weeks prior to first administration of study drug. If are not currently using NSAIDs or other analgesics for nr-AxSpA, research participants must not have received NSAIDs or other analgesics for nr-AxSpA for at least 2 weeks prior to first administration of the drug estudo.If are using corticosteroids oral, research participants should be receiving a stable dose equivalent to 10 mg of prednisone / day for at least 2 weeks prior to first administration of the study drug .If currently are not using corticosteroids, the research participants must not have received oral corticosteroids for at least 2 weeks prior to first administration of the study drug .If are using methotrexate, sulfasalazine or hydroxychloroquine, research participants should have started treatment at least 3 months prior to the first dose of study drug and should not present no serious toxic side effects attributable to these DMARDs.	Present radiographic sacroiliitis that meets the 1984 New York modified criteria. Present other inflammatory diseases that may confound the ratings of the benefit of treatment with ustekinumab, including, among others: rheumatoid arthritis, systemic lupus erythematosus or Lyme. Women that is pregnant, breastfeeding or planning a pregnancy or man that bear a child in a woman during inclusion in the study or within 5 months after receiving the last dose of the study drug .Have received any systemic immunosuppressant or DMARD other than MTX, SSZ or HCQ within 4 weeks before the first administration of the study drug .Have received leflunomide within 3 months before first dose of study medication or receiving leflunomide within 12 months prior to first administration of study drug and not having undergone a drug elimination procedure.Have received corticosteroids epidural, intra-articular, IM or IV, including adrenocorticotropic hormone during 4 weeks prior to the first administration of the study drug .Have ustekinumab or any other agent whose target is IL-23.Have prior received more than one anti-TNF agent .Have received infliximab or biosimilar infliximab within 12 weeks before the first administration of the study drug.Have received adalimumab, golimumab, certolizumab pegol. etanercept within 6 weeks prior to the first administration of the study drug .Have received prior biological treatment other than anti-TNF before the first dose of the study drug .Have ever received tofacitinibe or any other inhibitor of Janus quinases.Present any known hypersensitivity to human protein immunoglobulin .Have used citotoxics drugs .Present a history of active granulomatous disease before selection.Have received vaccination with Bacillus Calmette-Guérin within the 12 months prior to selection .Present a chest radiograph within the previous 3 months the first dose of study drug to show a suggestive abnormality of malignancy or current active infection, including  TB. Have presented a mycobacterial nontuberculous infection or oportunist infection.Have received, or is expected to receive any vaccination with alive virus or alive bacteria in the 3 months prior to the first administration of study medication during the study or within 3 months after the last administration of the study drug .Present one history of joint prosthesis infected or have received antibiotics for a suspected prosthetic joint infection. have presented a serious infection or have been hospitalized because of an infection or have been treated with IV antibiotics for an infection within the two months prior to the first administration of study drug. Presenting a history of infectious disease or current infectious disease, chronic or recurrent. Research participant present a history of positivity for antibodies to HIV or tested positive for HIV in selection. Present infection for Hepatitis B.Research Participantes who are positive for antibodies to hepatitis C.Present signs or current symptoms of kidney disease, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurological, brain or severe psychiatric, progressive or not controled. Present a known history of lymphoproliferative disease. The research participant presents a history of malignancy within 5 years prior to selection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-76cwjd	An Efficacy and Safety Study of JNJ- 56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy	Not yet recruiting	Intervention	2016-03-30	<NULL>	<NULL>	773	56021927PCR3003 - A Randomized, Double-blind, Placebocontrolled Phase 3 Study of JNJ- 56021927 in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment with Primary Radiation Therapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-15	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-76cwjd	<NULL>	Inclusion Criteria:Age &gt;= 18 years; Indicated and planned to receive primary radiation therapy for prostate cancer; Histologically confirmed adenocarcinoma of an intact prostate, and 1 of the following at diagnosis: 1) Gleason score &gt;=8 and &gt;=cT2c, 2) Gleason score &gt;=7, PSA &gt;=20 nanogram per mililiters (ng/mL), and &gt;=cT2c; Charlson comorbidity index (CCI) &lt;=3 - An Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) grade of 0 or 1; Adequate liver function: aspartate aminotransferase (AST), alanine aminotransferase (ALT), &lt;2 * upper limit of normal (ULN) and total bilirubin &lt;1.5 * ULN - Participants who are sexually active (even men with vasectomies) and willing to use a condom and agree not to donate sperm during the trial ; Signed, written, informed consent; Be able to swallow whole study drug tablets	"Exclusion Criteria:Presence of distant metastasis, including pelvic nodal disease below the iliac bifurcation &gt;2 cm in the short axis - Prior treatment with GnRH analogue or anti-androgen or both for &gt;3 months prior to randomization - Bilateral orchiectomy 
; History of pelvic radiation; Prior systemic (eg, chemotherapy) or procedural (eg, prostatectomy, cryotherapy) treatment for prostate cancer; History of seizure or condition that may predispose to seizure (including, but not limited to prior stroke, transient ischemic attack or loss of consciousness &lt;= 1 year prior to randomization; brain arteriovenous malformation; or intracranial masses such as schwannomas and meningiomas that are causing edema or mass effect); Prior treatment with enzalutamide, abiraterone acetate, orteronel, galeterone, ketoconazole, aminoglutethimide, estrogens, megestrol acetate, and progestational agents for prostate cancer; Prior treatment with radiopharmaceutical agents (eg, strontium-89) or immunotherapy (eg, sipuleucel-T) for prostate cancer; Prior treatment with systemic glucocorticoids ?4 weeks prior to randomization or is expected to require long-term use of corticosteroids during the study; Use of 5-alpha reductase inhibitors (eg, dutasteride, finasteride) &lt;=4 weeks prior to randomization; Use of any investigational agent &lt;=4 weeks prior to randomization; Current chronic use of opioid analgesics for &gt;=3 weeks for oral or &gt;7 days for non-oral formulations; Major surgery &lt;=4 weeks prior to randomization; Current or prior treatment with antiepileptic medications for the treatment of seizures;  Gastrointestinal conditions affecting absorption; Known or suspected contraindications or hypersensitivity to JNJ-56021927, bicalutamide or GnRH agonists or any of the components of the formulations - Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9jqhyc	Study to Evaluate Imetelstat (JNJ- 63935937) in Subjects with International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	774	A Study to Evaluate Imetelstat (JNJ- 63935937) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-02-01	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9jqhyc	<NULL>	Inclusion Criteria: Man woman greater than or equal to (&gt;=) 18 years of age; Diagnosis of myelodysplastic syndrome (MDS) according to World Health Organization (WHO) criteria or French- American-British (FAB) classification confirmed by bone marrow aspirate and biopsy within 12 weeks prior to Study Entry. A local laboratory report from this diagnostic bone marrow aspirate and biopsy must be reviewed and approved by the sponsor; International Prognostic Scoring System (IPSS) low Risk or intermediate-1 risk MDS; Red blood cell (RBC) transfusion dependent, defined as requiring 4 units RBC over 8 weeks during the 12 weeks prior to Study Entry; pretransfusion hemoglobin (Hb) should be less than equal to 9.0 gram per deciliter (g/dL) to count towards the 4 units total; Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2	Exclusion Criteria: Participant has known allergies, hypersensitivity, or intolerance to imetelstat or its excipients; Participant has received an investigational drug or used an invasive investigational medical device within 30 days prior to Study Entry or is currently enrolled in an investigational study; Prior treatment with imetelstat; Have received any chemotherapy, immunomodulatory or immunosuppressive therapy, corticosteroids greater than 30 milligram per day prednisone or equivalent, or growth factor treatment within 28 days prior to study entry; Have received other treatments for MDS within 4 weeks prior to Study Entry	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-774vv2	"A multicenter, randomized, double-blind study,
to verify whether the treatment with dextrocetamina association with clonidine in the form of cream for application to the skin is superior to placebo (cream without any drug) in the treatment of neuropathic pain."	Not yet recruiting	Intervention	2016-03-31	<NULL>	<NULL>	775	A multicenter randomized, double blind, placebo controlled study to determine the efficacy and safety of dextro-ketamine 1% in combination with clonidine 0.03% topical gel cream in the treatment of neuropathic pain syndromes.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-01-16	Faculdade de Medicina do ABC	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-774vv2	<NULL>	Signed and dated informed consent form. Male or female patients of any ethnic origin aged 18 years or over. Outpatient status. Patients with diagnosis of neuropathic pain associated with diabetic peripheral neuropathy (DPN), post herpetic neuralgia (PHN), post traumatic or post operative peripheral neuropathy and leprosy; DPN defined as peripheral, somatic or autonomic nerve damage attributable solely to diabetes mellitus; PHN defined as pain lasting longer than three months beyond the crusting of the skin lesions after an acute attack of Herpes zoster.Patients with moderate to severe pain all or most of the time, that has persisted for three months or longer (for patients with post herpetic neuralgia pain present for more than three months after healing of Herpes zoster skin rash. Patients with DN4 score 4. Patients with pharmacological therapies for neuropathic pain [anticonvulsants, selective and non- selective serotonin reuptake inhibitors, antidepressants, gabapentoids, nonsteroidal anti-inflammatory drugs (NSAIDS), salicylates, or acetaminophen] should be dose stabilized for at least 14 days before randomization and be willing to maintain therapy constant, avoid changes, or initiate new therapies throughout the study. Patients with normal cognitive and communicative ability as judged by clinical assessment and ability to complete self-report questionnaires. Women of childbearing potential must have a negative urine pregnancy test before randomization and must be using and willing to continue using adequate contraception (hormonal, double barrier or intrauterine device, according to medical indication) or be sexually abstinent during the study, and must not be lactating. Post-menopausal women for less than two years are considered of childbearing potential.	"Patients with severe pain associated with conditions other than diabetic peripheral neuropathy, post herpetic neuralgia, leprosy and post traumatic or post operative peripheral neuropathy [e.g., significant vasculitis, collagen vascular disorder, familial neuropathy, alcoholism, pernicious anemia, hepatitis, malignancy, syphilis, chronic inflammatory demyelinating polyradiculopathy, human immunodeficiency virus (HIV), medication-induced neuropathy, vitamin B12 deficiency, and others]. Patients with other sustained pain with intensity at, or greater than neuropathic pain. Patients with major depression requiring treatment. Patients with known allergy to clonidine or ketamine. Patients with ongoing use of a monoamine oxidase inhibitor. Patients with current use of antiarrhythmic drugs of class one (sodium channel blockers). Patients with uncontrolled diabetes mellitus (fasting blood glucose ? 130 mg/dL) or uncontrolled hypertension (systolic blood pression ? 180mmHg or diastolic ? 110mmHg). Patients using implanted medical device (e.g., spinal cord stimulator, intrathecal pump, or peripheral nerve stimulator) for pain treatment. Patients clinically hypotensive with a resting diastolic blood pressure &lt;60 mm Hg or a systolic blood pressure &lt;90 mm Hg.
Patients with diagnosis of any significant or unstable medical or psychiatric condition that would interfere with their ability to participate in the study. Patients with history of substance abuse disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) within the previous year. Patients with symptomatic or severe coronary insufficiency, clinically significant, cardiac conduction disturbances, myocardial infarction (within last 12 months), moderate to severe cerebrovascular disease, or severe chronic obstructive pulmonary disease (COPD) requiring oxygen therapy. Patients with serum creatinine value &gt;2 times the upper limit of normal or values for alanine transaminase (ALT) or aspartate transaminase (AST) &gt;2.5 times the upper limit of normal at screening. Patients treated with ketamine or clonidine oral, transdermal patch, or topical gel over the last four weeks prior to the screening visit.
Patients that used any topically applied pain medication within a period of 7 days before the screening. Patients with evidence of clinically significant peripheral vascular disease as evidenced by history of intermittent claudication or evidence of vascular ulcers, including venous stasis ulcers. Patients receiving any medications that could affect neuropathic pain not at stable dose for at least 14 days prior to the screening visit (other than medications containing NSAIDs and aspirin which must be stable for seven days prior to the screening visit). Patients receiving complementary therapies (acupuncture, TENS, central blockage)and/or &quot;alternative medicines&quot; (naturopathy, homeopathy, etc.) for pain treatment of 7 days prior to the screening visit. Patients with history of malignancy within the previous five years. Patients that have been hospitalized within 30 days of the screening visit, or planning to have a surgery during the study period. Patients with any dermatologic condition that could affect study drug absorption. Patients carrying pacemaker, impantable cardiac defibrillator, or cardiac resynchronizer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-55g4q3	Effects of a stretching program of the posterior muscles in patients with temporomandibular dysfunction	Other	Intervention	2016-04-01	<NULL>	<NULL>	776	Assessment of pain and mouth opening range of motion in patients with temporomandibular disorders subjected to stretching of the posterior chain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Sagrado Coração	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-55g4q3	<NULL>	Study participants; females; in the age group 20-50 years. diagnosed with temporomandibular dysfunction; who do not use drugs and are not performing any other intervention.	They will be excluded from the study that individuals are making use of analgesic drugs and aantiinflamatório ; also some other type of physical therapy intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6txnfv	"A Study of JNJ-56021927 Plus Androgen
Deprivation Therapy (ADT) Versus ADT in
Participants with Low-Volume mHSPC"	Not yet recruiting	Intervention	2016-04-01	<NULL>	<NULL>	777	56021927PCR3002 - A Phase 3 Randomized, Placebocontrolled, Double-blind Study of JNJ-56021927 Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects with Low-volume Metastatic Hormonesensitive Prostate Cancer (mHSPC)	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-11-20	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-6txnfv	<NULL>	Adenocarcinoma of prostate; if diagnosed greater than or equal to (&gt;=) 5 years from randomization; Metastatic disease documented by &gt;= 2 bone lesions on 99mTc bone scan; Eastern Cooperative Oncology Group Performance Status (ECOG PS) grade of 0, 1, or 2; Allowed prior treatment for prostate cancer: a) Maximum of 1 course of radiation or surgical intervention; b) Up to 6 cycles of docetaxel for low-volume disease with the last dose within 2 months of randomization; c) Must not have experienced disease progression between the last dose of docetaxel and Screening; Participants who did not receive prior docetaxel may have received less than or equal to (&lt;=) 3 months of ADT in the metastatic disease setting prior to randomization. Participants who received prior docetaxel may have received &lt;= 6 months ADT in the metastatic setting prior to randomization; May also have received up to 6 months of GnRHa in the adjuvant or neo-adjuvant setting as long as it was completed greater than (&gt;)1 year prior to randomization; May have received radiation therapy or prostatectomy as definitive therapy	Pathological finding consistent with small cell, ductal or neuroendocrine carcinoma of the prostate - Known brain metastases - Lymph nodes as only site of metastasis – Visceral metastasis observed on computed tomography (CT)/magnetic resonance imaging (MRI) or &gt;= 4 bone lesions on 99mTc bone scan with at least 1 lesion beyond the pelvis or vertebral column - Any prior malignancy within 5 years prior to randomization with the exception of squamous or basal cell skin carcinoma or non-invasive superficial bladder cancer - Prior treatment with other second generation anti-androgens or other CYP17 inhibitors, immunotherapy or radiopharmaceutical agents for prostate cancer - History of seizures or  medications known to lower seizure threshold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9pgk4f	A study of Intranasal Rapid Action Esketamine for Major Depression Treatment Resistant	Recruiting	Intervention	2016-04-01	<NULL>	<NULL>	778	A study of Intranasal Rapid Action Esketamine for Major Depressive Disorder Treatment Resistant	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-10	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9pgk4f	<NULL>	At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital - Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current episode of depression: Subject must be taking an oral antidepressant treatment with nonresponse at the start of the screening/prospective observational phase - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment	Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT - Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (C-SSRS) – Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6jr5nq	Cardiovascular risk factors assessment and the effect of physical activity and nutritional counseling for children and adolescents.	Data analysis completed	Intervention	2016-04-01	<NULL>	<NULL>	779	Cardiometabolic risk factors assessment and the effect of physical activity for children and adolescents: a continued study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-09	Universidade Federal de Santa Catarina	Edson Luiz da Silva	https://ensaiosclinicos.gov.br/rg/RBR-6jr5nq	<NULL>	Be enrolled in a public school of the city of Guabiruba-SC, both genders, have abdominal obesity and/or dyslipidemia.	Present preexisting conditions that preclude the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-3s39jp	Electrical stimulation effect to diminish pain on arm in women undergoing surgery for breast cancer	Recruitment completed	Intervention	2013-10-03	<NULL>	<NULL>	780	Electrical Analgesia Effect On Dysestesia In Women Undergoing To Axillary Linfadenectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-20	CNPq- Conselho Nacional de Desenvolvimento Científico e Tecnológico	Núcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3s39jp	<NULL>	Axillary lymphadenectomy for breast cancer, the presence of changes in skin sensitivity intercostal nerve pathway, ASA I or II; absence of cognitive disorders, hearing and visual	Attendance: skin lesions, active infectious processes; erysipelas; girth greater than 4 cm, breast reconstruction, bilateral mastectomy, neurological diseases, use of certain drugs such as anlagesic and antiinflammatory, use of a cardiac pacemaker; morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-35442h	Effects of aquatic exercise in functional activities in Parkinson&apos;s Disease	Recruitment completed	Intervention	2016-04-04	<NULL>	<NULL>	781	"Analysis of the effects of a aquatic exercise program in functionalactivities
 and posture of subjects with Parkinson&apos;s disease"	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-35442h	<NULL>	Both genres. Clinical diagnosis of idiopathic Parkinson Disease. Stages 1-4 in the Hoehn and Yahr scale. Clinical Certificate for aquatic physical activity and to attend heated pool.	Not having independent gait related or unrelated to Parkinsons Disease. Another disease that could interfere with the physical assessments such as changes in the balance of vestibular. Visual or auditory sensory deficit that prevented follow verbal and visual instructions. Contraindications to attend heated pool, such as fever, incontinence, severe change in blood pressure, open wound. Change in the parameters of drug intake based on L-dopa during the study period. Do not agree with the TCLE. Present change in drug prescription during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-386vfr	Stimulation of reaching behavior using sticky mittens in preterm infants	Recruiting	Intervention	2016-04-04	<NULL>	<NULL>	782	Practice of reaching using sticky mittens in preterm infants: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-15	Universidade Federal de Mato Grosso do Sul (UFMS)	Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (Fundect)	https://ensaiosclinicos.gov.br/rg/RBR-386vfr	<NULL>	Infants born with less than 37 weeks of gestational age; with first and fifth minute Apgar Scores greater than 7;  without major pre- and perinatal complications; at maternal care.	High-risk infants; with clinical signs/diagnosis of neurological impairment, congenital malformations, genetic syndromes, visual and auditory alterations, cardiorespiratory difficulties or musculoskeletal impairment; who do not collaborate during pre-training and post-training measures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-7gy99f	Relationship of female sexuality with physical activity, depression, quality of life and muscle force	Recruiting	Observational	2016-04-04	<NULL>	<NULL>	783	Female sexual function: relationship with physical activity, depression, quality of life and functionality of the pelvic floor and abdominal muscles	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7gy99f	<NULL>	Undergraduate; students of Biological Sciences Sector courses of the Federal University of Parana; female; over the age of eighteen; who have active sex life; that has not pregnant; without distinction of race; without distinction of sexual orientation; without distinction of class social.	Women in pregnancy; sexual abstinence in the past six months; suffering from neuromuscular diseases; which do not show integrity to the pelvic floor sensitivity test or had a surgical procedure in abdominal/pelvic or musculoskeletal surgery region in the lower limbs at least six months; women who are making use of psychiatric drugs for example antidepressants and anxiolytics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-247s9q	Study of Intranasal Rapid Action Esketamine for treatment of Major Depressive Disorder Treatment Resistant	Recruiting	Intervention	2016-04-04	<NULL>	<NULL>	784	"A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed
Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects with Treatment-resistant Depression - ESKETINTRD3001"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-06-29	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-247s9q	<NULL>	man or woman 18 years old (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age; meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD without psychotic features based upon clinical assessment and confirmed by the Mini-International Neuropsychiatric Interview (MINI); At the start of the screening/prospective observational phase; participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration as assessed using the Massachusetts General Hospital Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records for the current episode of depression. Participant must be taking an oral antidepressant treatment with nonresponse at the start of the screening/prospective observational phase; At the start of the screening/prospective observational phase participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34; The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment	Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode. to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (i.e. duloxetine. escitalopram. sertraline. and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ) or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode defined as at least 7 treatments with unilateral ECT; Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression; Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis. bipolar or related disorders (confirmed by the MINI). comorbid obsessive compulsive disorder. intellectual disability (only DSM-5 diagnostic code 319). borderline personality disorder. antisocial personality disorder. histrionic personality disorder. or narcissistic personality disorder; Participant has homicidal ideation/intent per the investigator’s clinical judgment or has suicidal ideation with some intent to act within 6 months prior to the start of the screening prospective observational phase per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (C-SSRS); Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-4hqbmf	Effects of two types of weight training: traditional and blood flow restriction on the strength, power, muscle mass and performance in daily activities in the elderly	Data analysis completed	Intervention	2016-04-04	<NULL>	<NULL>	785	Effects of two types of weight training: conventional and partial restriction of blood flow on the muscle strength and power, muscle quality and functional performance in elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-30	Universidade Federal da Paraíba	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4hqbmf	<NULL>	"Ages from 55 years; show complete functional independence; be physically active; not perform strength training in the last six months; not have the disease:
arthritis, arthritis, neuropathy, chronic obstructive pulmonary disease; not present cardiac arrhythmias; deep vein thrombosis; not having suffered myocardial infarction within 6 months prior to the intervention period; not reporting muscle or joint injury in the lower limbs; do not use heart pacemaker; submit ankle brachial index situated between 0.90 and 1.40; speed normal pulse wave; Normal central systolic pressure."	Do not get minimum frequency of 75% to the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8q3p8n	Pilates and Global Postural Reeducation to school children.	Recruiting	Intervention	2016-04-05	<NULL>	<NULL>	786	Comparative study of Mat Pilates and Global Postural Reeducation protocol on postural alignment and functional capacity of school children.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8q3p8n	<NULL>	Children with good cognition; with aged 4-8 years.	Children with previous orthopedic surgery; cardiac, respiratory or psychological conditions that compromise the implementation of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-89xvwj	Demographic mapping and characterization of physical therapy care profile offered in neonatal intensive care units in the city of Rio de Janeiro	Data analysis completed	Observational	2016-04-05	<NULL>	<NULL>	787	Characterization of physical therapy profile offered in neonatal intensive care units in Rio de Janeiro City	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-89xvwj	<NULL>	Hospitals offering neonatal intensive care in Rio de Janeiro during the study period.	They were excluded from the study hospitals whose leaders delivered the questionnaires incompletely and hospitals whose ICUs were mixed, that is, also provided assistance to pediatric public.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-4jsgbc	Use of drugs to prevent sensitivity of post tooth bleaching	Recruitment completed	Intervention	2016-04-07	<NULL>	<NULL>	788	Use of analgesics in preventing sensitivity arising from tooth bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-03	Universidade Estadual de Ponta Grossa- UEPG	Universidade Estadual de Ponta Grossa- UEPG	https://ensaiosclinicos.gov.br/rg/RBR-4jsgbc	<NULL>	Patients older than 18 years are included; with good oral and general health; with free maxillary anterior teeth restorations; do not carious lesion present; that have the color of A2 or darker teeth according to the color scale Classical Vita (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who already underwent tooth whitening, pregnant or lactating patients; who report tooth sensitivity; severe browning (staining tetracycline, fluorosis or endodontics); with parafunctional habits, patients with dental prostheses and appliances Orthodontic and any other oral pathology will be deleted; patients who have systemic symptoms such as problems stomach, heart, kidney and liver, diabetes, hypertension or who are making continuous use of any medication with analgesic action and anti-inflammatory	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-25372s	Clinical Effects of Diet on Dental Bleaching	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	789	Clinical Effects of Diet Change Directive During In-office Bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-25372s	<NULL>	For the presente study, it will be selected 60 patients with the following inclusion criteria: Above 18 years-of-age; Front teeth free of caries and periodontal disease; At least one upper central incisor of A2 or darker color.	Patients who have already undergone whitening treatment; Patients with prosthesis or restorations on the labial surface of the front upper teeth; Patients with severe internal alterations of color (fluorosis and stains by tetracycline); Pregnant or lactating women; Smokers; Patients using fixed orthodontic appliances;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-836wwd	Effect of prior application of 10% potassium nitrate in reducing tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	790	Preoperative application effect of 10% potassium nitrate reduction in tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-26	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-836wwd	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology . Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems, diabetes, hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-3h33wy	Ciprofloxacin effectiveness of the assessment to prevent bacterial infection of patients victims of accidents with snake in the Brazilian Amazon	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	791	Early empirical antibiotic therapy: a randomized clinical trial for superiority of a ciprofloxacin versus placebo in for preventing secondary bacterial infection among snakebite victims in the Brazilian Amazon	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-07-10	Universidade do Estado do Amazonas	Fundação de Amparo à Pesquisa do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3h33wy	<NULL>	To have less than 24 hours of the accident; did not to use any antibiotics before answering the institution; to have not done the antivenom for the current snakebite ; to have no abscess or infection clearly established at the time of admission ; not to be allergic to the antibiotic of choice in this study ; not to be pregnant and not accept participate.	have mental inability to understand the objectives of the study and participate in the survey; have acute or chronic unstable; unavailability of stay in hospital for seven days to follow.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-9b969b	"An Electronic Program to help people to take
decision to quit smoking"	Recruiting	Intervention	2016-04-10	<NULL>	<NULL>	792	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-9b969b	<NULL>	Smokers assets; age above 18 years; of both sexes; in the treatment at the Centro Hiperdia Minas -Juiz de Fora and e Serviço de controle de Hipertensão; Diabetes e Obesidade da Prefeitura Municipal de Juiz de Fora who signed the free and informed consent.	Active smokers under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8txsrk	Physiotherapy approach to cellulite and preoperative and postoperative abdomen surgery	Data analysis completed	Intervention	2016-04-10	<NULL>	<NULL>	793	Evaluation and Physical therapy in women with fibro geloid edema and preoperative and postoperative abdominoplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8txsrk	<NULL>	Group cellulite: Healthy volunteers; gender female; aged between 18 and 40 years; with asymmetry of cellulite in the gluteus; with pelvic tilting. Group abdominoplasty: Healthy volunteers; gender female; aged between 18 and 40 years; undergoing abdominoplasty.	Group cellulite: pregnant women; those with maintenance impossibility of bipedalism for prolonged periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-275ybt	Effects of Exercise Program on Work Environment	Data analysis completed	Intervention	2016-04-10	<NULL>	<NULL>	794	Effects of Workplace Exercise Program: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-275ybt	<NULL>	Volunteers of both sexes aged between 25 and 50 years; which they were in accordance with the methods and signed the informed consent form ; who worked in the factory production area.	Disability or depressive autorelato .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-49mqhs	Evaluation of partial  caries removal in primary and permanent molars over time	Recruiting	Intervention	2016-04-10	<NULL>	<NULL>	795	"Partial caries removal in primary and permanent molars:
Longitudinal clinical trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-26	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-49mqhs	<NULL>	Eighty Children aged 8 to 15 years; both genders; carrying at least one deep active occlusal caries lesion (inner half dentin diagnosed radiographically) in previously unrestored primary and permanent molar and complying the score 3 index Nyvad without pulpal involvement (cavity in enamel and dentin; visible to the naked eye; cavity surface softened or leathery to soft probe).	Children who have debilitating systemic diseases that might interfere with some of caries risk factors; children with salivary changes (xerostomy) and / or are making use of medicines in the last 3 months like the use of antibiotics. Teeth with clinical signs or symptoms and radiographic findings that may assume irreversible pulp inflammation or pulp necrosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-9ns5db	Abiraterone acetate in Patients With Metastatic Castration-Resistant Prostate Cancer	Recruitment completed	Intervention	2016-04-11	<NULL>	<NULL>	796	Abiraterone acetate in Patients With Metastatic Castration-Resistant Prostate Cancer, Chemo-naive, Who Received a Prior Diethylstiboestrol Therapy- 212082PCR2036	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-10-21	Faculdade de Medicina do ABC	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9ns5db	<NULL>	Histologically or cytologically confirmed adenocarcinoma of the prostate without neuroendocrine differentiation or small cell histology; Prior therapy with diethylstilbestrol (DES) for castration resistant prostate cancer; Participants should demonstrate evidence of progression on DES or evidence of grades 3/4 toxicities on DES; Metastatic disease documented by positive bone scan or metastatic lesions on computerized tomography (CT) or magnetic resonance imaging (MRI); May have received prior androgen blockage (bicalutamide or flutamide) but must have been discontinued for least 28 days;  Ongoing androgen deprivation therapy (ADT) (luteinizing hormone-releasing hormone [LHRH] agonist or orchiectomy), with serum testosterone level of less than 50 nanogram per deciliter (1.7 nanomole per liter); Eligible participants must maintain ADT	Active infection or other medical condition that would make prednisone use contraindicated; Any chronic medical condition requiring a higher systemic dose of corticosteroid than 5 milligram (mg) prednisone per day; Pathological finding consistent with small cell carcinoma of the prostate; Known brain metastasis; Has had prior cytotoxic chemotherapy or biologic therapy for the treatment of metastatic castration-resistant prostate cancer (mCRPC)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-3j6xjy	Effects of medical telephone discussion on the endocrinology referral list	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	797	Evaluation of the effectivity of teleconsultations for improving the quality of the referrals from primary care to specialized care of patients nonresidents in Porto Alegre with endocrine health conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Programa de Pesquisa e Pós-Graduação em Epidemiologia / Universidade Federal do Rio Grande do Sul	Secretaria Estadual da Saúde do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3j6xjy	<NULL>	Referrals from patients from counties with at least 5 endocrinology referrals waiting appointment for endocrinology specialty. Referrals from adult patients (more than 18 years old). Referrals from the primary care. Referrals which the reason for referral is included in one of the referring protocols (Diabetes Mellitus; Hypothyroidism; Hyperthyroidism; Goiter; Thyroid nodule; Obesity).	Referrals from patients from counties with more than one hundred endocrinology referrals waiting appointment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-244gpz	Influence of exercises performed by physiotherapists in newborns prematuos to improve breathing	Data analysis completed	Intervention	2016-04-12	<NULL>	<NULL>	798	Influence of sensorimotor stimulation of the respiratory system of preterm infants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-13	Universidade Federal do Mato Grosso do Sul	Hospital Regional de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-244gpz	<NULL>	Gestational age 28semanas up to 36 weeks and 6 days; hemodynamically stable ; over 72 hours of life ; breathing spontaneously and may or may not be with O2 catheter use; no congenital malformations ; minimum weight of 1,100 grams.	Patients with congenital malformations ; hemodynamically unstable ; intraventricular hemorrhage Peri grade III and / or IV ; weight loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-6rytw2	Physical Exercise and Health of Institutionalized Older Adults	Recruitment completed	Intervention	2016-04-13	<NULL>	<NULL>	799	Physical Exercise, Mental and Physical Health of Institutionalized Older Adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-05	Programa de Pós-graduação em Neurologia - Neurociências da Universidade Federal Fluminense	Centro de Tratamento para a Doença de Alzheimer, Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6rytw2	<NULL>	Living at long term care institution for elderly; Aged 60 years or more.	No medical release to perform physical effort; acute musculoskeletal injury; advanced neurodegenerative disease; incapacity of communication; incapacity to understand simple commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-83nfhp	The effect of pilates exercise on vagina strength	Data analysis completed	Intervention	2016-04-14	<NULL>	<NULL>	800	"The influence of the pilates method in the contractility of the pelvic floor muscles of
student at open university to elderly people, unapi/ufms"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-83nfhp	<NULL>	social volunteers; eutrophic, female; non smokers; age of 50 years; Sedentary and signed an informed consent form.	Women alcoholics; with clinical diagnosis of pelvic floor dysfunction; with a history of urinary tract infection; with history of previous gynecological surgery; with neurological or endocrine-metabolic disorders. Women who are allergic to latex.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-25ck6t	Assessment of balance and muscle function in elderly women with osteoporosis after exercises with vibratory rod	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	801	Analysis of functional balance and electromyographic activity of elderly women with osteoporosis submited of balance training with vibratory rod	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Estadual Paulista- Faculdade de Filosofia e Ciências	Marcelo Tavella Navega	https://ensaiosclinicos.gov.br/rg/RBR-25ck6t	<NULL>	Older; aged 60-80 years; with osteoporosis diagnosed by bone densitometry examination considering T-Score:equal or less than -2.5 SD; physically active acording to IPAQ which considered moderate and vigorous activities daily and weekly according to 8 answer questions; no pain; no fracture; no severe soft tissue injury in the six months preceding the study; no neurological changes; no cardiovascular changes; no respiratory changes; score upper to 18 points in Mini-Mental State test which considers that guidance notions, immediate memory, attention and calculation, recall and language.	pain, fractures or severe soft tissue injury in the 6 months preceding the study, and neurological, cardiovascular or respiratory diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-2x86dc	"Observational study to assess data from the past related to the rate of hospitalization in
Patients with Schizophrenia treated one year before with oral drugs for Schizophrenia and
one year after with injectable drugs for Schizophrenia"	Recruiting	Observational	2016-04-15	<NULL>	<NULL>	802	"A retrospective, observational study to assess the rate of hospitalization in
patients with Schizophrenia treated one year before with oral Antipsychotics and
one year after with long acting injectable Atypical Atipsychotics"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-04	Universidade Federal de São Paulo - UNIFESP/EPM	Janssen-Cilag Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2x86dc	<NULL>	"Out-Patients with the main diagnosis of schizophrenia; only clinical records with complete information during the 2 years period
selected for data analysis will be included; patients treated with oral antipsychotics then switched to long acting injectable atypical due to poor adherence, lack of efficacy (no significant symptom reduction, judged by physician, at maximum recommended dose of an antipsychotic for 6 weeks), patients’ choice, when the switch has not been clearly justified or the switch has not been done during hospitalization; being regularly treated with long acting injectable atypical antipsychotics for at least 1 year after the initial use of long acting injectable atypical antipsychotics."	Patients that started long acting injectable atypical antipsychotics treatment as in-patients and patients that switched to long acting injectable atypical antipsychotics during hospitalization; patients with schizophrenia resistant to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-6q5rd5	The impact of dogs therapy for children with cancer	Not yet recruiting	Intervention	2016-04-18	<NULL>	<NULL>	803	The impact of the Animal Assisted Therapy (AAT) in oncological pediatric patients on physiological and psychosocial variables	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Fundação Pio XII	Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-6q5rd5	<NULL>	Children of both sexes; 6 to 12 years old; diagnosis of a solid tumor; current diagnosis or relapse less than six months; with good clinical condition; signature of the Terms of Consent and Assent.	"Exclusion Criteria (study): children did not identify with the TAA; with serius mental problems what can cause an accident with the animal; no conclusion of the TAA program; incomplete answers to questionnaires applied; to allergic animals.

Exclusion criteria for the sessions: isolation precaution; presence of wound surgical; use of invasive device; presence of ostomy; neutropenia; fever; diarrhea; vomiting; respiratory symptoms; being hospitalized."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5pc43m	Auriculotherapy to reduce pain, anxiety and improving the quality of life	Recruiting	Intervention	2016-04-19	<NULL>	<NULL>	804	Effectiveness of auriculotherapy to reduce pain and anxiety and improving the quality of life of nursing professionals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-26	Escola de Enfermagem da Universidade de São Paulo	Leonice Fumiko Sato Kurebayashi	https://ensaiosclinicos.gov.br/rg/RBR-5pc43m	<NULL>	The subjects of the nursing staff (auxiliaries, technicians and nurses) that present a score above 33 points according to the State-Trait Anxiety Inventory (middle and high level of anxiety) and those who have availability of time for submission to the sessions.	Pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants during the period of research; those who have metal and adesive tape allergy and who initiate other complementary therapies (acupuncture, massage, herbal medicine, Reiki, Flower therapy etc.) for anxiety control during the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3f8rzs	Effects of low level laser therapy in the electromyographic fatigue of bíceps brachi muscle before and after a resistive program training in young males	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	805	Effects of low level laser therapy in the electromyographic fatigue, in the blood lactate, and in the inflamatory markers after induced biceps  biceps brachi muscle fatigue before and after a resisitive  program training in young males	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3f8rzs	<NULL>	"Full active range of motion and no pain in the shoulder, elbow and wrist; 
Absence of fracture or previous surgery on spine and upper extremities; 
Considered insufficiently active for IPAQ; 
Not be in training for at least six months."	"Restriction in range of motion of shoulder, elbow and wrist; 
History of trauma or previous surgery in trunk; upper extremities; 
History biceps muscle injury; 
Subluxation of the glenohumeral joint; 
Rheumatic, neurological or degenerative disease;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-6zc4cb	Comparitive study between Carnoy and GEWF solutions for identifying lymph nodes in patients with cancer of the large bowel	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	806	Randomized clinical trial comparing Carnoy&apos;s and GEWF solutions for Lymph Node Clearing Technique in Colorectal Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Hospital Moinhos de Vento	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6zc4cb	<NULL>	Patients with histologically proven adenocarcinoma of the colon or rectum; both sexes; over 18 years of age; underwent surgical treatment performed by colorectal surgeons; agreement of the attending physician and the patient to participate in the study ;	Inaccuracy or unavailability of patient´s data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5dm7g2	Study to evaluate the efficacy and safety of the implant of Cerebral Hypothermia Exclusive by Nasopharyngeal (posterior region of the nose) Catheter use to Treatment of severe Head trauma	Not yet recruiting	Intervention	2016-04-25	<NULL>	<NULL>	807	Efficacy and Safety of Hypothermia Cerebral Exclusive deployment through the use of catheter Nasopharyngeal in Human Beings for the treatment of seriuos (ou (severe) brain trauma Phase I Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dm7g2	<NULL>	Patients both male and female aged 18 to 70 years; Confirmed diagnosis of TBI; Glasgow Coma Scale 8; Use of definitive airway devices (tracheal tube, tracheostomy or cricotireoideostomia); Ssaturation of oxygen (O2) blood above 92%; Monitoring Indication of PIC by the neurosurgery team responsible for the case; patients, or their legal representatives who signed the informed consent.	Patients with early brain temperature &lt;35.5 ° C; Pregnancy known or obvious; Obstructive lesions of the upper airways; Confirmed diagnosis of skull base fracture or cerebrospinal fluid leaks evident nasally; Diagnosis cervical spine fracture confirmed with contraindications to cervical mobilization, even with the use of cervical collar; Blood Pressure 6-average &lt;65 mmHg in the last two hours; Use of antibiotics in the last two hours or signs of current infection or sepsis; Known use of anticoagulants in therapeutic dose; Bleeding not controlled; Signs of brain death or borderline flow by transcranial Doppler (TCD); Glasgow Coma Scale 3 associated with pupils without photoreaction; Current participation in another clinical study in progress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-25zmjm	Nutritional status and inflammatory profile of patients with cancer of the oral cavity in pre-antineoplastic treatment (Chemotherapy/Radiotherapy/Surgery) before and after nutritional supplementation.	Recruitment completed	Intervention	2016-04-25	<NULL>	<NULL>	808	Nutritional status and inflammatory profile of patients with cancer of the oral cavity in pre-antineoplastic treatment (Chemotherapy/Radiotherapy/Surgery) before and after nutritional supplementation.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-23	Instituto Nacional de Câncer	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-25zmjm	<NULL>	The inclusion criteria were patients who were referred to the Outpatient Clinic of nutrition in pre-antineoplastic treatment (chemotherapy/radiotherapy/surgery) with cancer of the oral cavity enrolled at the National Institute of Cancer, age between 40 to 75 years, malnutrition or nutritional risk, and agreed to participate in the study by signing the Free and Informed Consent Term after being informed about the reasons for the study and collaboration that is expected of them.	Exclusion criteria were diabetes mellitus, liver disease, renal disease, treatment with radiotherapy or chemotherapy already started or has already performed at another time.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-29grfm	Study to evaluate the response to treatment with the medication pasireotide LAR and the expression of the substances AIP and miR-34a in patients with acromegaly	Not yet recruiting	Intervention	2016-04-25	<NULL>	<NULL>	809	Prospective, non-randomized, phase II study to assess the AIP and miR-34a expressions and the response to pasireotide LAR treatment in acromegaly patients	<NULL>	2, single-arm-study, n/a	2	<NULL>	<NULL>	<NULL>	2016-06-01	Faculdade de Medicina - Universidade Federal do Rio de Janeiro (UFRJ)	Faculdade de Medicina - Universidade Federal do Rio de Janeiro (UFRJ)	https://ensaiosclinicos.gov.br/rg/RBR-29grfm	<NULL>	Age between 18 and 80 years; clinical indication of surgery as part of the treatment; laboratory and clinical confirmation of acromegaly; Signature of written informed consent.	"Contraindications to surgery due to high surgical risk; Previous radiotherapy for pituitary adenoma treatment; Presence of AIP mutation; Medical treatment with somatostatin analogues, dopamine agonists or GH antagonist before surgery; Patients with compression of the optic chiasm causing any visual field defect that requires surgical intervention; Diabetic patients with poor glycaemic control as evidenced by HbA1c &gt;8%; Patients with symptomatic cholelithiasis and acute or chronic pancreatitis; Patients with risk factors for torsade de pointes, i.e. patients with a baseline QTcF &gt;450 ms in males, and &gt;460 ms in females; Hypokalaemia, hypomagnesaemia, uncontrolled hypothyroidism, family history of long QT syndrome or concomitant medications with known risk of Torsades de pointes (TdP); Patients who have congestive heart failure (NYHA Class III or IV), unstable angina, sustained ventricular tachycardia, clinically significant bradycardia, advanced heart block, history of acute myocardial infarct less than one year prior to study entry or clinically significant impairment in cardiovascular function; Concomitant disease(s) that could prolong the QT interval such as autonomic neuropathy (caused by diabetes or Parkinson’s disease), HIV, cirrhosis, uncontrolled hypothyroidism or cardiac failure; Patients with liver disease such as cirrhosis, chronic active hepatitis, or chronic persistent hepatitis, or patients with ALT/AST &gt; 2.0 X ULN, serum bilirubin &gt;2.0 X ULN; Presence of Hepatitis B surface antigen (HbsAg) or Hepatitis C antibody test (anti-HCV); Patients with serum creatinine &gt;2.0 X ULN; Patients with white blood cells &lt;3 X 109/L; Hb 90% &lt; LLN; Platelets &lt;100 X 109/L; Patients with active malignant disease in the last five years (with the exception of basocelular carcinoma or in situ cervix carcinoma); Patients with the presence of active or suspected acute or chronic uncontrolled infection; Patients who have undergone major surgery/surgical therapy for any cause within 4 weeks prior screening; Patients with abnormal coagulation (PT and/or APTT elevated by 30% above normal limits) or patients receiving anticoagulants that affect PT (prothrombin time) or APTT (activated partial thromboplastin time); History of syncope or family history of idiopathic sudden death; History of immunocompromise, including a positive HIV test result (ELISA and Western blot); known hypersensibility to somatostatin analogs or any other component of pasireotide; Sexually active males unless they use a condom during intercourse while taking drug and for 3 months following last dose of pasireotide and should not father a child in this period. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid; Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test; Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and 3 months following last dose of pasireotide. Highly effective contraception methods include: abstinence (when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception; Female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy) or tubal ligation at least six weeks before taking study treatment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment; Sterilization (at least 6 months prior to screening). For female subjects on the study the vasectomized male partner should be the sole partner for that subject; Combination of any two of the following: Use of oral, injected or implanted hormonal methods of contraception or other
forms of hormonal contraception that have comparable efficacy (failure rate &lt;1%), for example hormone vaginal ring or transdermal hormone contraception; Placement of an intrauterine device (IUD) or intrauterine system (IUS); Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository; In case of use of oral contraception women should have been stable on the same pill for a minimum of 3 months before taking study treatment; Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of child bearing potential."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-9nq7qd	Study to evaluate and compare anti retroviral tablet formulations for oral fixed dose and solutions in children	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	810	Open, randomized study to evaluate the safety and pharmacokinetic parameters comparing antiretroviral formulations fixed-dose tablet and oral solution in pediatric population	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2015-10-28	Universidade Federal de Minas Gerais	Instituto de Tecnologia em Fármacos - Farmanguinhos	https://ensaiosclinicos.gov.br/rg/RBR-9nq7qd	<NULL>	"Weight between 6.5 and 24.9kg;Confirmed HIV infection; documented by positive results from two samples collected at different times prior to entering the study:Sample # 1 can be tested using:Two rapid tests from two different manufacturers antibodies or based on principles and different antigenic determinants (for larger participants 18 months);An essay EIA OR Western blot OR immunofluorescence assay OR chemiluminescence assay (for larger participants 18 months);A PCR HIV DNA;A quantitative PCR HIV DNA (&gt; 5,000 copies / mL);A qualitative PCR HIV DNA;
A complete test detection of nucleic acids for the HIV virus;2. Sample # 2 can be tested using:An EIA confirmed OR Western blot OR immunofluorescence assay OR chemiluminescence assay (for larger participants 18 months);
A PCR HIV DNA;A quantitative PCR HIV DNA (&gt; 5,000 copies / mL);A qualitative PCR HIV DNA;
A complete test detection of nucleic acids for the HIV virus;In use of highly active antiretroviral therapy (HAART); with stable laboratory tests (viral load and CD4 +) or treatment-naïve;Demonstrate availability and willingness to ingest the drugs studied;
5. Willingness to stay in the hospital for 12 hours for pharmacokinetic study;Parents or legal guardians must be able; agree and are willing to sign the Instrument of Consent;
Female participants; after menarche; must agree to use two forms of contraception from the menarche;Note: female participants with reproductive potential (after menarche) with sexual activity that can result in pregnancy; they must agree to avoid pregnancy in a consistent and appropriate manner with at least two of the following contraceptive methods: condoms; diaphragm or cervical cap with spermicide; IUD; hormonal contraceptives."	Values outside normal laboratory tests in step 4; according to the DAIDS toxicity table (Annex IV); up to 2 weeks before study entry;Vomiting and diarrhea (greater than grade 2) at least 30 days prior to study entry;Treatment of bacterial; viral or acute severe opportunistic;History of drug toxicity requiring discontinuation of any study drug;Hypersensitivity to drugs under study;medical or surgical problems affecting motility or gastrointestinal absorption (eg: ileus; ulcerative colitis) or liver function;Treatment with experimental drugs within 30 days prior to study entry;Any acute hepatitis;Chemotherapy for cancer;Any disease or clinically significant findings during the medical assessment or physical examination that; in the opinion of the investigator; may interfere with the study;Pregnancy;Failure immune defined as:Incomplete immune response: defined as a failure in subjects with severe immunodeficiency (baseline CD4 percentage &lt;15%) to achieve at least five percentage points increment or children 5 years of age; to increase the absolute value of CD4 . at least 50 cells / mm3 during the first year of treatment;Immune Worsening: defined as the sustained drop of five points in the percentage of CD4 at any age; or fall to values below the absolute number of pretreatment CD4 in children 5 years of age (Brazil; 2009).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-8qtdw4	Functionality, muscle strenght and balance in elderly woman after physical exercise and vitamin D supplementation	Data analysis completed	Intervention	2016-04-25	<NULL>	<NULL>	811	Functional capacity, muscle strenght and balance in elderly woman after physical conditioning, water aerobic and vitamin D supplementation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-06-01	Universidade Federal de São Paulo	Maysa Seabra Cendoroglo	https://ensaiosclinicos.gov.br/rg/RBR-8qtdw4	<NULL>	"eldely woman; 60 years of age and older; 
practicing exercise at SESC ;
and sedentary elderly women"	Acute disease; physical dependency; dementia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-8b33r8	Early bedside sedestation after heart surgery: clinical and psychological repercussions.	Recruitment completed	Intervention	2016-04-25	<NULL>	<NULL>	812	early bedside sedestation in the postoperative cardiac surgery: clinical and psychological repercussions .	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-11	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8b33r8	<NULL>	patients older than 18 years undergoing cardiac surgery; sign the Informed Consent and Informed .	reoperation after surgery; those who come to peri -operative death; present need for invasive mechanical ventilation for longer than 24 hours; hospital stay above 10 days after surgery; are doing use of tranquilizers and antidepressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-69zxf4	Pain and child anxiety perceived during atraumatic and conventional restorative treatments by 5-to 8-yr-old school children	Data analysis completed	Intervention	2016-04-26	<NULL>	<NULL>	813	Perception of pain and anxiety related to atraumatic restorative treatment (ART) and conventional treatment by 5-to 8-yr-old school children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Odontologia e Centro de pesquisas São Leopoldo Mandic	REGINA N M TAVARES	https://ensaiosclinicos.gov.br/rg/RBR-69zxf4	<NULL>	6- to 8-yr-old children with good systemic conditions, have at least two bilateral decayed primary molars with Black&apos;s class-II dentinal caries cavity, without pain,pulp involvement and periapical lesion, signed individual informed consent forms by parents and children, to accept the restorative treatment without local anaesthesia in the dentist appointment day	children under 5 years or over 8 years, have less than two bilateral decayed primary molars in the mouth, teeth with pain, apical lesions, and pulp involvement, use of anesthesia during the procedure on the day of the dentist appointment day, individual informed consent form not signed by the parents or the child	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-6p9fjg	Motivational interviewing in patients with heart failure	Recruitment completed	Intervention	2016-04-27	<NULL>	<NULL>	814	The effect of motivational interviewing through the home visit and telemonitoring in patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6p9fjg	<NULL>	Patients older than 18 years; with a diagnosis of Heart Failure , regardless of etiology; have face care with a multidisciplinary clinical team specializing in IC, because telephone consultation work strengthening classroom guidelines; preserved or reduced ejection fraction; functional class NYHA I- III; have signed the free and informed consent form.	patients with cognitive neurological disease; patients with no direct telephone contact.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-28z7r7	The electrical stimulation&apos;s influence of medium and low frequency on the functional performance of soccer players	Recruiting	Intervention	2016-04-27	<NULL>	<NULL>	815	The influence of medium and low frequency currents on the functional performance of soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-28z7r7	<NULL>	"Male (n=30).
Age between 18-30 years.
Being college player of field football.
To be at least three months without practice strength training."	"Presenting some kind of dysfunction in skeletal muscle that may interfere.
Presenting intolerance in neuromuscular electrical stimulation.
Injury history or surgeries in lower limb que affect the application of electrical stimulation.
Continuous use of analgesics; tranquilizers; antidepressants or other central agent.
Vascular or cardiovascular problems; chronic diseases; muscle or neurological disorders that can not permit a complete executions of activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-2dwhkm	Effects of a technique using apparatus and one using manual technique both for removal of bronchial secretions in hospitalized children.	Not yet recruiting	Intervention	2016-04-27	<NULL>	<NULL>	816	Effects of a new vibrotherapy instrument &quot;Pulsar&quot; and vibro in children in the hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2dwhkm	<NULL>	Both genders; aged between 29 days to 3 years old; who require respiratory therapy in the first 48 hours of hospitalization.	Clinical situations that respiratory physiotherapy this contraindicated as bleeding with hemodynamic instability, intracranial pressure higher than 20 mmHg; chest tube; pneumothorax; open wounds and chest skin infections; osteomyelitis of the ribs; osteoporosis and rib fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-9s8t88	Cardiovascular effects of the perineal muscles contractions in pregnant women	Recruiting	Intervention	2016-04-27	<NULL>	<NULL>	817	Cardiovascular responses to pelvic floor muscle contractions in pregnant women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9s8t88	<NULL>	18 weeks of pregnancy;age group of 18 to 40; body mass index (BMI) for gestational age according to Atalah Table (Atalah SE et al, 1997).; first or second pregnancy.	High-risk pregnancy; drugs use; prolapse of pelvic organs; history of pelvic surgery; taking drugs that influence BP and HR (beta blockers; calcium channel inhibitors; anti anxiety drugs); vaginal palpation Intolerance (examination);inability to perform muscle contraction (P &lt;2 according to PERFECT method Laycock&amp; Jerwood (2001)); changes in the cardiovascular and respiratory systems; cardiovascular and diabetes diseases diagnosed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-7r9f2m	Self-care and adherence: the impact of an educational program for patients with heart failure	Recruitment completed	Intervention	2016-04-28	<NULL>	<NULL>	818	Self-care and adherence: the impact of an educational program for patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-31	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-7r9f2m	<NULL>	Medical diagnosis of Heart failure independent of etiology, with normal ejection fraction or diminished, age higher or equal 18 years and functional classes I-III NYHA (New York Heart Association)	Event acute myocardial infarction three months before insertion in the research; revascularization surgery in the previous month or the same need; patients with neurological sequelae cognitive, not reside in the cities of Niterói, São Gonçalo or Rio de Janeiro and has no phone contact direct.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-82bcmz	Effects of low level laser therapy in muscle fatigue of elderly women pre and post a quadríceps femoris exercise program	Recruiting	Intervention	2016-04-28	<NULL>	<NULL>	819	Effects of low level laser therapy in peripherical muscle fatigue in elderly women submitted to a program of muscular strength	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-31	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-82bcmz	<NULL>	"No pain or dysfunction in trunk and lower extremities 
Full active range of motion of hip, knee and ankle
Absence of fracture or previous surgery in the spine and lower extremities
Considered insufficiently active for IPAQ"	"Pain in the lower extremities or trunk; 
Restriction in range of motion of hip, knee and ankle; 
History of trauma or previous surgery in  lower extremities or spine; 
History of quadriceps femoris muscle injury; 
Subluxation of  hip joint; 
Osteoarthritis in  hip and knee; 
Rheumatic e, degenerative or neurological diseas; 
Diabetes mellitus and fibromyalgia; 
Subjects with uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3yrqfq	Association of malaria during pregnancy with problems in the development of the fetus in the Brazilian Amazon	Recruitment completed	Observational	2016-04-28	<NULL>	<NULL>	820	Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-12-05	Instituto de Ciências Biomédicas - USP	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-3yrqfq	<NULL>	Pregnant women; minimum age of 13 years; all parity; any gestational age; who present or not infections by Plasmodium sp. in their gestation period.	Pregnant women smokers; hypertension; diabetes; who had preeclampsia or eclampsia; show hemorrhage due to other diseases; multiple pregnancy; HIV infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-8ccym2	Evaluation of the amounts of metal released in saliva of patients undergoing orthodontic treatment with metal or esthetic appliances	Data analysis completed	Observational	2016-04-29	<NULL>	<NULL>	821	Comparative study of the nickel presence in saliva of patients em treatment with metalic or esthetic orthodontic brackets	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade e Centro de Pesquisas São Leopoldo Mandic	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8ccym2	<NULL>	Control groups consisted of patients who had never undergone movable or fixed orthodontic treatment; more than 15 years-old; both genders. Metal group consiste of patients undergoing between one month up to one year of orthodontic treatment; with a fixed appliance composed of stainless steel brackets; with metallic archwire; four metal bands on the permanent molars; more than 15 years-old; a minimum of 20 teeth with orthodontic accessories; without the use of any type of palatine or lingual devices welded to the bands; or auxiliary extra-oral orthodontic appliances; both genders. Esthetic group consisted of patients undergoing between one month up to one year of orthodontic treatment with a fixed orthodontic appliance composed of self-ligating polycarbonate brackets; with metallic archwire coated with esthetic cover; more than 15 years-old; a minimum of 20 teeth with orthodontic acessories; without the use of any type of palatine or lingual devices welded to the bands; or auxiliary extra-oral orthodontic appliances; both genders.	Smokers; patients with metal prosthetic parts; amalgam restorations; or with periodontal disease; those using any type of medication in the 24 hours preceding saliva sample collection; or those with a  history of orthodontic treatment prior to the present treatment; more than 40 years-old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5r8syp	Effect of nursing care on prevention of dry eye in adult patients admitted to the Intensive Care Unit	Not yet recruiting	Intervention	2016-04-29	<NULL>	<NULL>	822	Randomized clinical trial: effect of nursing interventions on prevention of dry eye in critically ill patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Santa Casa Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5r8syp	<NULL>	"Be over 18 years;
did not present dry eye at the time of admission;
stay in the ICU for at least 24 hours;
be in mechanical ventilation therapy;
glance less than 5 per minute;
comatose, sedated or Glasgow less than or equal to 7; 
consent to participate in research or have."	"Have not the responsabille authorization;
Patients with severe eye disease or with history of adverse effects after use of any of the interventions proposed and not tolerate the treatment: artificial tear gel, artificial tear liquid and saline 0.9%."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-7gkwdj	Laser therapy in patients with knee artrosis	Recruitment completed	Intervention	2014-07-09	<NULL>	<NULL>	823	Laser therapy in patients with knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gkwdj	<NULL>	Age over 50 year, knee osteoartritis unilateral or bilateral within 2 years with pain in following tasks: up and down stairs, kneeling, seat and down up, running and standing up for 2 minutes, Kellgren-Laurence grade II or III and BMI&lt;35	Diabetes mellitus, untreated hipertension blood pressure, previous knee replacement, neurologics deficits, neuropathics disorders, physically active (more than 2 times a week), alcoholic and cancer diagnosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-47v3fh	Effect of overhead respiratory muscle on performance in the six-minute walk test in patients with systolic heart failure	Data analysis completed	Intervention	2016-04-29	<NULL>	<NULL>	824	Effect of respiratory muscle fatigue on performance in the six-minute walk test in outpatients with systolic heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-20	Universidade Federal Fluminense Faculdade de Medicina Hospital Universitário Antônio Pedro	Clínica de Insuficiência Cardíaca Coração Valente Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-47v3fh	<NULL>	Patients over 40 years, diagnosed with heart failure with reduced ejection fraction confirmed (Boston criteria), and that part of clinical treatment of heart failure program of the University Hospital Pedro Antonio	Patients with heart rate greater than 120 bpm rest, systolic blood pressure greater than 180 mmHg, diastolic blood pressure greater than 100 mmHg; Malnutrition, as evidenced by a body mass index less than 20 kg / m2; Cold and / or flu in the previous 4 weeks and use of psychotropic drugs, muscle relaxants and immunosuppressants; Inability to walk due to musculoskeletal problems; chest pain previous 4 weeks; cognitive changes that prevent the realization of the Protocol; chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4f9tcc	Efficacy and safety study of Fluticasone Furoate/Vilanterol on the dose of 100/25 microgram (mcg) inhalation powder, Fluticasone Propionate/Salmeterol on the dose of 250/50 mcg inhalation powder and Fluticasone Propionate on the dose of 250 mcg inhalation powder in adults and adolescents with persistent asthma	Recruiting	Intervention	2016-04-29	<NULL>	<NULL>	825	A randomized, double blind, double dummy, parallel group, multicenter study of once daily Fluticasone Furoate/Vilanterol 100/25 mcg inhalation powder, twice daily Fluticasone Propionate/Salmeterol 250/50 mcg inhalation powder, and twice daily Fluticasone Propionate 250 mcg inhalation powder in the treatment of Persistent Asthma in adults and adolescents already adequately controlled on twice daily inhaled Corticosteroid and long acting beta2 Agonist	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-09	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4f9tcc	<NULL>	"Subjects must give their signed and dated written informed consent to participate prior to start any study activities;
Subjects must be outpatients equal or more than 12 years of age at visit 1 and diagnosed with asthma, as defined by the National Institutes of Health, for at least 12 weeks prior to visit 1;
Male and female (if eligible). An eligible female is defined as having non-childbearing potential or having childbearing potential and a negative urine pregnancy test at screening and agrees to use an acceptable method of birth control consistently and correctly;
Subjects must have a FEV of equal or more than 80% of the predicted normal value;
If they have received mid dose of inhaled corticosteroids(ICS) plus Beta-2 agonist prolonged action (LABA), equivalent to Fluticasone Propionate/Salmeterol 250/50 micrograms(mcg) twice daily or an equivalent combination via separate inhalers for at least the 12 weeks immediately preceding visit 1;
Subjects must be able to replace their current SABA treatment with albuterol/salbutamol aerosol inhaler at visit 1 for use, as needed, for the duration of the study. Subjects must be able to with hold albuterol/salbutamol for at least 6 hours prior to study visits;
If in the opinion of the investigator the subject&apos;s asthma is well controlled"	"History of life-threatening asthma, defined for this protocol as an asthma episode that required intubation and/or associated with hypercapnea, respiratory arrest or hypoxic seizures within the last 5 years;
Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of visit 1 and led to a change in asthma management or in the opinion of the investigator, expected to affect the subject&apos;s asthma status or the subject&apos;s ability to participate in the study;
Any asthma exacerbation requiring oral corticosteroids within 12 weeks of visit 1 or resulting in an overnight hospitalization requiring additional treatment for asthma within 6 months prior to visit 1;
A subject must not have current evidence of atlectasis, bronchopulmonary dysplasia, chronic bronchitis, chronic obstructive pulmonary disease, pneumonia, pneumothorax, interstitial lung disease, or any evidence of concurrent respiratory disease other than asthma;
A subject must not have any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the results if the condition/disease exacerbated during the study;
A subject must not have used any investigational drug within 30 days prior to Visit 1 or within five half-lives (t½) of the prior investigational study, whichever is longer of the two;
Any adverse reaction including immediate or delayed hypersensitivity to any beta2-agonist, sympathomimetic drug, or any intranasal, inhaled, or systemic corticosteroid therapy. Known or suspected sensitivity to the constituents of the study molecules;
History of severe milk protein allergy;
Administration of prescription or non-prescription medication that would significantly affect the course of asthma, or interact with study drug;
A subject must not be using or require the use of immunosuppressive medications during the study;
A subject will not be eligible if he/she or his/her parent or legal guardian has any infirmity, disability, disease, or geographical location which seems likely (in the opinion of the Investigator) to impair compliance with any aspect of this study protocol, including visit schedule and completion of the daily diaries;
Current tobacco smoker or has a smoking history of 10 pack-years (20 cigarettes/day for 10 years). A subject may not have used inhaled tobacco products or inhaled marijuana within the past 3 months (e.g., cigarettes, cigars, electronic cigarettes, or pipe tobacco);
A subject will not be eligible for this study if he/she is an immediate family member of the participating investigator, sub-investigator, study coordinator, or employee of the participating investigator"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-35t7jy	Is it possible to quantify defecation at defecography?	Recruitment completed	Intervention	2016-05-02	<NULL>	<NULL>	826	Correlation between the percentage of weight reduction in the amount of evacuated contrast medium and the variation in the percentage of area reduction of the rectal ampulla after cinedefecography.	<NULL>	1, n/a, n/a	1	<NULL>	<NULL>	<NULL>	2016-03-01	Hospital de Base de Brasília	Hospital de Base de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-35t7jy	<NULL>	female sex; aged 18 to 80 years; constipated.	fecal incontinence and/or who refused to sign the consent form; patients without clinical indication for cinedefecography; pregnant women or those with suspected pregnancy;  patients who could not undergo radiological tests; and patients who underwent previous surgery of the rectum.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4vwqck	Identification of risk of accidents in healthy elderly and with Parkinson&apos;s Disease during street crossing simulation: A study based on gait characteristics	Recruiting	Observational	2016-05-03	<NULL>	<NULL>	827	Identification of risk of accidents in healthy elderly and with Parkinson&apos;s Disease during street crossing simulation: A study based on kinematic parameters	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-12-08	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-4vwqck	<NULL>	No pain, fracture, or serious injury to soft tissues in the 6 months previous to the study; no history of cognitive, respiratory or cardiovascular disorders not controlled; elderly with Parkinson&apos;s disease be classified in stages I to III of Hoehn Yahr scale; elderly with Parkinson&apos;s disease not be in pharmacological adaptation phase.	Individuals who present uncontrolled cardiovascular changes; to present score lower than 24 on the Mini Mental State Examination that will be applied before the collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-7699xz	Analysis of walking training with partial weight support for post stroke patients.	Data analysis completed	Intervention	2016-05-04	<NULL>	<NULL>	828	Multidisciplinary analysis of a motor rehabilitation protocol with partial weight support for post stroke patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Pontifícia Universidade Católica do Paraná	Centro Hospitalar de Reabilitação Ana Carolina Moura Xavier	https://ensaiosclinicos.gov.br/rg/RBR-7699xz	<NULL>	"The intended sample of 50 volunteers must satisy the following criteria:
Confirmed stroke; lower limb residual hemiparesis; score 1 to 5 at Functional Ambulation Cathegory; age above 18 years old."	Present sequelae in both sides of the body or bilateral stroke; Diagnosed cardiac condition instable; present another neurological conditions (i.e. Alzheimer, Parkison, dementia, cerebelar disease, severe cerebelar disorders, etc); severe muscoloskeletal lower limb disorders not related to stroke and might interefere in gait; trunk circumference shorter than 36 cm or larger than 142 cm, body mass larger than 138 kg, height larger than 210 cm, due to the limitations of tue body weight support equipment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-2bz6v8	Vocabulary of children with Down syndrome	Data analysis completed	Observational	2016-05-04	<NULL>	<NULL>	829	Receptive and expressive vocabulary of children with Down Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2bz6v8	<NULL>	"Experimental Group (EG): to have a diagnosis of Down Syndrome (Trisomy 21); have been born at term; have not been born with very low weight; have results indicative of normality in the neonatal auditory, visual and metabolism screenings (mainly for congenital hypothyroidism); do not have characteristics of the Autism Spectrum Disorder; have visual skills to carry out the activities proposed; attend rehabilitation procedures since the first trimester of life; be attending regular school (public) and be in the age group between 36 the 62 months of chronological age. 

Comparative group 1 (GC1) and Comparative Group 2 (GC2): to have typical neuropsychomotor development; have been born at term; have not been born with low weight; have results indicative of normality in the neonatal auditory, visual and metabolism screenings; do not have characteristics of the Autism Spectrum Disorder; have visual abilities to carry out the activities proposed; be paired according to gender, mental age (CG1), chronological age (CG2), school and socioeconomic status with the EG."	Presented: congenital hypothyroidism; born with very low weight; born preterm; signals of the Autism Spectrum Disorder; not initiated the rehabilitation procedures early and not attending school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9rpqdn	Use of medication for preventing diabetes in obese pregnant women	Recruiting	Intervention	2016-05-04	<NULL>	<NULL>	830	Use of metformin for the prevention of gestational diabetes mellitus in obese pregnant women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-31	Universidade da Região de Joinville Univille	Universidade da Região de Joinville Univille	https://ensaiosclinicos.gov.br/rg/RBR-9rpqdn	<NULL>	With obesity diagnosis of pregnant women will be selected according to the criteria of the World Health Organization with BMI or greater than 30 kg / m2; aged over 18 years; singleton pregnancy; with screening for gestational diabetes mellitus (GDM) at the beginning of the negative pregnancy; gestational age less than 20 weeks; no pathology that interferes with glucose metabolism; no hypersensitivity to metformin hydrochloride or important drug allergy; history or presence of liver disease; renal or gastrointestinal or other conditions that interfere with the absorption, distribution, excretion or metabolism of the drug.	Losses following are deleted; intolerance drugs; desire of the pregnant woman; presence of risk to the fetus; allergy to metformin, mother&apos;s death and fetus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-83c6y8	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	Data analysis completed	Intervention	2016-05-05	<NULL>	<NULL>	831	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-05	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-83c6y8	<NULL>	Any patient presenting complex ventricular arrhythmia in the stress phase of the exercise test.	Patients with cardiac implantable devices; incapacity to keep walking after exercise phase; atrial fibrillation or flutter; technical artifacts in the electrocardiogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9ztf3b	The use of intranasal ketamine before puncturing a vein in children	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	832	Ketamine intranasal used as sedative for punch venosa in pediatric patients	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2015-11-16	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9ztf3b	<NULL>	Children hospitalized in the Pediatric Inpatient Units, with the presence of legal guardian; aged 3 months to 12 years; requiring venipuncture independent research.	Severe neurological sequelae; Patients who need immediate venipuncture at risk; Presence of active nosebleeds; Patients using antipsicotrópicos; Children who have experienced clinical change with ketamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-63wb6k	Prevalence of risk factors for heart diseases in children and adolescents in Botuverá -SC: a continued study	Data analysis completed	Observational	2016-05-05	<NULL>	<NULL>	833	Prevalence of cardiometabolic risk factors in children and adolescents of Botuverá-SC: a continued study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Catarina	Edson Luiz da Silva	https://ensaiosclinicos.gov.br/rg/RBR-63wb6k	<NULL>	Be enrolled in a public school of the city of Botuverá-SC, both genders.	Not included exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3ysnwj	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	834	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Fundação de Amparo à Pesquisa do Estado de São Paulo	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3ysnwj	<NULL>	preterm infants with gestational age less than or equal to 32 weeks ; Hospitalized Neonatal Intermediate Care Unit; in spontaneous breathing ; without central or peripheral venous access ; babies without congenital malformations or chromosomal syndromes or infections in treatment ( change of blood count and blood culture positive ) or neurological disorders ( intracranial hemorrhage grade III or IV, and brain malformations ) ; without skin lesions or other contraindications to body immersion in hot water	adverse reactions to the study protocol (cyanosis , crying or lethargy, facies pain , generalized hyperemia , among others); Epidermal changes ; worsening of symptoms ; intolerance to food or behavioral disorders; events that prevent the study protocol ( need for ventilatory support or intravenous and surgical procedures ) ; parents and / or guardians who request to withdrawn from the infant study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-2jvj92	Assessment of Cardiovascular Risk  and Inflammatory Markers in Patients with Rheumatoid Arthritis	Recruitment completed	Observational	2016-05-05	<NULL>	<NULL>	835	Assessment of Oxidative Stress, Cardiovascular Risk Factors and Metabolic Syndrome Frequency in Rheumatoid Arthritis Patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Estadual de Londrina	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-2jvj92	<NULL>	Patients with rheumatoid arthritis who meet the criteria of the American College of Rheumatology 2010.	Patients with other autoimmune diseases, kidney, heart, liver, diabetes, acute or chronic infectious diseases; use of metformnas and statins, supplements with antioxidant activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3bfyzc	Management of Split-thickness skin graft donor sites: a clinical trial with three diferent dressings	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	836	Management of Split-thickness skin graft donor sites: a randomized clinical trial comparative with three diferent dressings	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-10-13	Centro Universitário Cesmac	Aldenir Feitosa dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-3bfyzc	<NULL>	Pacients submitted to Split-thickness akin graft surgery; age between 18 and 60 years; both sexes; donor site dimension around 10x20cm	Volunteers that carriers Diabetes; liver failure; Chronicle obstructive pulmonar disease and chronicle renal insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-5497s9	Clinical study to assess the safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	Not yet recruiting	Intervention	2016-05-05	<NULL>	<NULL>	837	53718678RSV1005 - A Phase 1b, randomized, partially doubleblind, placebo-controlled study to assess the pharmacokinetics, safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2015-11-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP-USP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5497s9	<NULL>	Inclusion Criteria: Participant has presented at the hospital for suspected Respiratory Syncytial Virus (RSV) infection within 72 hours prior to Screening completion; Participant has been hospitalized for this suspected RSV infection; Participant has been diagnosed with RSV infection using a polymerase chain reaction (PCR)-based assay, preferably commercially available locally; Participant was born after a normal term pregnancy (greater than or equal to 37 weeks and 0 days); A legally acceptable representative of the participant must sign an Informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the study, are willing for their child to participate in the study, are willing for their child to remain in the hospital for the first 3 days of dosing (even if not clinically indicated), and are willing/able to adhere to the prohibitions and restrictions specified in the protocol and study procedures	Exclusion Criteria: Participant who had major surgery within the 28 days prior to randomization or planned major surgery through the course of the study; Participant has major congenital anomalies or known cytogenetic disorders; Participant has known or suspected immunodeficiency, such as known human immunodeficiency virus (HIV) infection; Participant has known or suspected hepatitis B or C infection; Participant is upon current admission initially hospitalized in the Intensive care unit (ICU) and/or in need of invasive endotracheal mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-43v3tk	Orthoses for thumb osteoarthritis: a functional and kinematic analysis	Not yet recruiting	Observational	2016-05-06	<NULL>	<NULL>	838	The Use of Orthotics for Thumb Osteoarthritis: Kinematic and Functional Analysis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade de Brasília - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-43v3tk	<NULL>	Subjects diagnosed with osteoarthritis of the thumb joint carpometacarpia, via radiographic and clinical indicative suggested by the American College of Rheumatology. Will be included subject  with osteoarthritis severity between rates 1 and 3 in the Radiographic Kellgren-Lawrence, corresponding to mild to moderate disease status. Inclusion criteria also will consider patients over 18 years, with no age  limit and subjects who present no cognitive limitations that prevent them from answering the Health Assessment Questionnaire, a self administered instrument that assesses the degree of difficulty in performing activities of daily living.	Subjects withupper limb pain or functional limitations. Subjects with thumb OA in stage 4 of Kellgren-Lawrence Radiographic Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-6npfkm	Evaluation of post-operative pain following use of reciprocating instrumentation technique in root canal treatment.	Data analysis completed	Intervention	2016-05-06	<NULL>	<NULL>	839	Evaluation of post-operative pain following use of reciprocating instrumentation technique in endodontic.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-13	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6npfkm	<NULL>	78 volunteers; male; aged between 18 and 64 years; that already had endodontic treatment indication in permanent molars teeth; diagnosed with necrotic pulp with or without asymptomatic apical periodontitis.	Volunteers at the time of intervention were administering antibiotics or corticosteroids during the treatment; with immunocompromised; which would complicate the systemic disease; these factors could change the perception of pain or interfere with the score analysis of postoperative pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-352v3g	The simulated nursing education and the clinical competency development	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	840	The simulated nursing education and the clinical competency development	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Departamento de Enfermagem daUniversidade Federal do Paraná	Departamento de Enfermagem daUniversidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-352v3g	<NULL>	To be a undergraduation nursing student; registered on fourth period of the course during  2015 and 2016.	To have a previous course on healh sciences; or competence as a medical personal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3vn24z	Releasing adhesive use on premature with  transparent dressingfor fixing central catheter: randomazed clinical trail	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	841	Releasing adhesive use on premature with semipermeable transparent film por PICC (Peripheral Inserted Central catheter) fixation: randomazed clinical trail	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-14	Universidade Federal do Paraná	Barbara Franco Mittag	https://ensaiosclinicos.gov.br/rg/RBR-3vn24z	<NULL>	"Premature infants less than 36 weeks gestational age at birth;
RNs in use of semipermeable film transparent for fixing of peripheraly inserted central cateter (PICC) inserted in the first two weeks of life;
The consent form signed by those responsible."	"Presence of the skin lesion near of the catheter, prior to insertion;
Fixing the peripheraly inserted central cateter (PICC) with different material than transparent semipermeable film;
Withdrawal of informed consent by those responsible;
Parents under the age of 18 years."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-8m6dt4	Effects of physiotherapy followed by the motor imagery on the mobility of patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2016-05-10	<NULL>	<NULL>	842	Repercussions of motor training followed of mental practice in functional mobility of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-08	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8m6dt4	<NULL>	Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease; aged between 45 and 75 years; of both sexes; in stage 1-3 of the Hoehn and Yahr scale (HY); they are research volunteers.	Patients with other neurological diseases; patients reporting uncompensated systemic diseases (untreated), such as hypertension; with compromised cognitive level assessed by the Mini-Mental State Examination (MMSE); unsatisfactory motor imagination assessed by questionnaire Visual Imagery and Kinesthetic (KVIQ-20); in physical therapy service for 3 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4mt6yr	Effects of speech therapy on chewing of individuals who underwent surgery to correct an imbalance in facial pattern	Recruitment completed	Intervention	2016-05-10	<NULL>	<NULL>	843	Effects of  miofunctional therapy on masticatory function of patients undergoing orthognathic surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-20	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-4mt6yr	<NULL>	Experimental group: age between 18 and 45 years; regardless of gender and present Class II malocclusion or Class III malocclusion. Control group: young adults; good health both general and oral; relationship between dental arches with horizontal and vertical overlap between 1 and 3 mm; natural dental elements at least until the second molar; nasal breathing.	Neurological psychiatric and intellectual deficits; partial or total edentulous patients; presence of cleft lip and palate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-2bxdxd	Restorations of primary teeth in multiple cavities	Recruitment completed	Intervention	2016-05-10	<NULL>	<NULL>	844	Clinical performance of ocluso-proximal ART restorations in primary teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-30	Universidade Camilo Castelo Branco	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2bxdxd	<NULL>	&quot;healthy volunteers; both genders; between 4 and 5 years of age; clinically presenting proximal caries lesion in primary teeth; lesion accessible to manual instruments used in atraumatic restorative treatment&quot;.	&quot;non-cooperative children; presence of fistula or abscess near the tooth selected to the research; presence of pulp exposure or mobility in the selected tooth&quot;.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-37fdyk	Treatment of VI nerve lesion by superior rectus muscle shifting to lateral rectus muscle	Recruitment completed	Intervention	2016-05-10	<NULL>	<NULL>	845	Treatment of VI nerve palsy by superior rectus muscle transposition to lateral rectus muscle	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-30	Universidade federal do Maranhao	Universidade federal do Maranhao	https://ensaiosclinicos.gov.br/rg/RBR-37fdyk	<NULL>	Subjects ranging from 01 to 100 years old diagnosed with VI nerve palsy	"If patient denies to engage the research
If he/she presents other ophthalmic pathologies but the one evaluated"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-287q65	Impact of exercise on the urinary control muscles in women with Multiple Sclerosis	Recruiting	Intervention	2016-05-16	<NULL>	<NULL>	846	Impact of pelvic floor training in the treatment of symptoms of lower urinary tract in women with multiple sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-287q65	<NULL>	Women diagnosed with Multiple Sclerosis;  age over 20 years; score on the Expanded Disability Status Scale (EDSS) lower or equal to 6.5; presence of symptoms of urinary dysfunction for at least six months.	Refusal to participate; exacerbation of symptoms  of Multiple Sclerosis during treatment; cognitive decline;  imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-4kgb26	A new method of exercise prescription creation for  cardiac rehabilitation to heart disease	Recruitment completed	Intervention	2016-05-16	<NULL>	<NULL>	847	A new method of exercise prescription creation for  cardiac rehabilitation program phase II to heart failure patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Hospital cardiológico costantini	Pontificia Universidade Catolica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4kgb26	<NULL>	"Patients with heart failure aged more than 50 years; Patients Functional class III or II and according to the New York Heart Association (NYHA ) ;
40 volunteers"	"- Patients under the age of 50 years;
patients With left ventricular ejection fraction&gt; or = 50 %;patients  with associated lung disease ;patients with orthopedic contraindication to practice exercises"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-468wm2	Effect of interventions on the quality of sleep and stress in people with Diabetes	Not yet recruiting	Intervention	2015-12-09	<NULL>	<NULL>	848	"Effect of non-pharmacological interventions on the quality of sleep and stress
emotional in people with Type 2 Diabetes Mellitus"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-468wm2	<NULL>	People with Type 2 Diabetes Mellitus in clinical follow-up in that service; aged greater than 18 years; both sexes; who have active telephone contact; not forming any pharmacological / non-pharmacological treatment for improving sleep quality or that interferes it.	People that are experiencing cognitive impairment , according to an evaluation of the Mini -Mental State Examination ( MMSE), according to the educational tracks; People who submit total score on the Pittsburgh Sleep Quality Index (PSQI less than or equal to 5, defining them as &quot;good sleepers&quot;); Night Workers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-9k7dmc	The use of the R1T1 robot as aid in the preoperative process in the Transplant of the Liver	Recruitment completed	Observational	2016-05-17	<NULL>	<NULL>	849	The use of the R1T1 robot as aid in the preoperative process in the Transplant of the Liver Organ	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade estadual de Campinas	Project Company	https://ensaiosclinicos.gov.br/rg/RBR-9k7dmc	<NULL>	Healthy volunteers; both genders; age between 18 and 60 years; trained personnel who participate directly in the activities carried out with the robot R1T1.	There are no exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-8xgqzr	Physiotherapy for childbirth preparation	Data analysis completed	Intervention	2016-05-17	<NULL>	<NULL>	850	Role of physical therapy during pregnancy fopr childbirth preparation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-21	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8xgqzr	<NULL>	Women; between 20 and 35 years; primigravidae; belonging to UBS the municipality of Assisi; normoglycemic and normotensive; gestational period of 18 to 36 weeks.	Women; under 18 or over 36 years; multiparous; hypertensive or diabetic; with risk pregnancy indication; women who left to attend the service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-4hsfyg	Comparison of effect of bath performed before hip prosthesis surgery with three different solutions	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	851	Comparison of preoperative bathing effectiveness with three solutions in patients undergoing hip arthroplasty: a clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-18	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-4hsfyg	<NULL>	Patient with an elective procedure of total hip arthroplasty; age of 18 years or more; no report of infection at the surgical site; with access to landline or mobile; know autodiagnosticar informing the clinical signs of the infection or have a responsible with this ability; don&apos;t be Staphylococcus aureus nasal carrier prior to surgery.	Patient treatment of surgical site infection; undergoing hip replacement surgery in urgency situations; emergency; orthopedic trauma; with a history of allergic reactions to the products used in the bath; underwent partial hip arthroplasty surgery; nasal Staphylococcus aureus carriers before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-49pk78	Comparison of Cicatrization Using Topic Light Emitted Diode in Patients Underwent to Abdominoplasty	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	852	Comparison Between the Application and No Application of Led (light emitted diode) in Cicatrization of Patient Underwent to Abdominoplasty	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	INSERM U1051 Institut des Neurosciences de Montpellier	https://ensaiosclinicos.gov.br/rg/RBR-49pk78	<NULL>	Patients with informed consent signed; caucasian; patients underwent abdominoplasty; patients in whose immediate postoperative period does not show signs of distress or mechanical trauma of the sutured tissue; BMI between 20-30 kg/m2	Patient with indication of multifunctional abdominoplasty or previously undergone to bariatric surgery; patients previously undergoing abdominal surgery that could compromise the vitality of the abdominal flap (cholecystectomy laparotomy for weapon or firearm trauma); patients with autoimmune disorders of collagen metabolism; smoking; diabetes mellitus; chronic hypertension; alcoholism; bleeding disorder; protein malnutrition; immunodeficiency; patients suffering acute or chronic dermatitis or using pharmacological treatment with corticosteroids or chemotherapy; patients undergoing radiation therapy for any reason in the abdominal-pelvic region; patients with known healing disorders (hypertrophic scars or keloids); patients with intestinal bad absorption; patients who have been conducting strict diet prior to surgery; patients who are using another type of product or drug for preventing or improving healing; patient presenting tattoo in the abdominal region and difficult the postoperative evaluation of the scar; patients with medical conditions that interfere with normal wound healing (vitamin C deficiency; iron deficiency; anemia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5tt55v	Flower Essences in relieving anxiety during labor.	Not yet recruiting	Intervention	2016-05-19	<NULL>	<NULL>	853	Flower essences : effects on anxiety during  labor pain.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Escola Paulista de Enfermagem-Universidade Federal de São Paulo	Secretária Municipal de Saúde de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-5tt55v	<NULL>	Do not have obstetric pathologies; Being in the active phase of labor, diagnosed on admission by the treatment team minimum 3 cm cervical dilatation and maximum of 8 cm; term gestational age between 37 and 42 completed weeks calculated by last menstrual period and  or the result of early ultrasound, that is held up to 20 weeks; Minimum age of 18 years; pregnancy with a single fetus alive.	Smokers who has smoked less than two hours after nicotine influence on catecholamine secretion; Bearers of mental disorders, documented in the medical record, which would influence his decision and autonomy; They reported having ingested caffeine in the last 10 hours, thus altering the secretion of catecholamines; Users of psychoactive drugs, which influence his decision and autonomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-796g9q	Effects of weightlifting and aerobic training on bofy fat and laboratory blood tests in adolescents with overweight and obesity	Data analysis completed	Intervention	2016-05-20	<NULL>	<NULL>	854	Effect of resistance and aerobic training program on body composition, lipid profile and high sensitive c-reactive protein of overweight and obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade do Estado do Rio Grande do Norte	Centro Municipal de Controle à Obesidade Jansen Jefferson Diógenes e Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-796g9q	<NULL>	Adolescents of both sexes; aged between 12 and 15 years old; being overweight and obesity according to the cutoff points proposed by the World Health Organization; no history of previous experience with resistance exercises or systematic program of aerobic exercises	Attest use of tobacco, alcohol or other drugs; present some limitation that prevents the execution of any exercise; pregnancy; present endocrineisease; be making chronic drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-25gnjc	Simulation in the nursing student&apos;s self-confidence	Recruitment completed	Intervention	2016-05-21	<NULL>	<NULL>	855	Effect of simulation in the nursing student&apos;s self-confidence to emergency operations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-15	Universidade Federal do Rio de Janeiro	Fundação Educacional de Macaé	https://ensaiosclinicos.gov.br/rg/RBR-25gnjc	<NULL>	Second or third year degree in Nursing. To have 18 years old or more. Have not had prior contact with courses or first aid and emergency training.	Technical training in nursing. Professional role as technician or nursing assistant. First aid training. Participate in research projects or extension that deal with the subject will be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-7zxk77	Aquatic exercises and health education for the treatment of fibromyalgia	Data analysis completed	Intervention	2016-05-21	<NULL>	<NULL>	856	Hydrotherapy and health education for the treatment of fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Centro Universitário de Formiga - MG (UNIFOR-MG)	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-7zxk77	<NULL>	women who have a confirmed diagnosis of fibromyalgia by a physician and according to the new diagnostic criteria proposed by the American College of Rheumatology in 2011. Regardless of race; aged between 25 and 60 years; BMI below 30; who read and sign the Consent and Informed (IC) not using drugs for more than three months or with stable pharmacological treatment for more than three months.	women who did not sign the consent form; which violate the data collection protocol; which change the drugs during the study period; using steroidal anti-inflammatory drugs or nonsteroidal; pregnant women; nursing mothers; patients with a history or presence of cancer or diseases autoimmune; psychiatric; infectious and inflammatory or in the period of data collection or in the three months prior to data collection will also excluded patients who do not participate in at least 80% of the activities proposed by the researchers (EIF and Hydrotherapy).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2z5rgg	A study to validate A Glucose-6-Phosphate Dehydrogenase enzyme assay	Data analysis completed	Intervention	2016-05-22	<NULL>	<NULL>	857	A follow-up of validation test protocol enzyme glucose 6-phosphate dehydrogenase ( G6PD ) to study TAF112582	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Fundação de Medicina Tropical do Amazonas	Medicines for Malaria Venture	https://ensaiosclinicos.gov.br/rg/RBR-2z5rgg	<NULL>	"The subject is between 18 and 45 years of age,  male; 
Hgb concentration greater or equal than 12g/dL; 
Reticulocyte count less or equal than 2.5%; 
A signed and dated informed consent from the subject or the subject’s legal representative prior to screening"	"History of haemoglobinopathy; 
Past or current history of methaemoglobinaemia or methaemoglobin percentage above 3%; 
Past medical history of G6PD deficiency; Any other co-morbidity or treatment that, in the opinion of the investigator might
influence haematopoiesis; 
Any person that may have donated blood in the last 56 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-8fgft5	Clinical evaluation of ceramic veneers manufactured by computed technology	Recruiting	Intervention	2016-05-22	<NULL>	<NULL>	858	Clinical evaluation of lithium disilicate veneers manufactured by cad/cam technology	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade de São Paulo, Faculdade de Odontologia de Bauru	Fundação de Amparo à Pesquisa do estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-8fgft5	<NULL>	"Patients over 18 years;
Accordance with the TCLE;
Patients who have an indication for veneers: discoloration, tooth wear, fracture or anterior teeth with malformation;
Patients who have good general health during clinical evaluation period, good value mandibular and maxillary occlusal stability;
Patients who have need of treatment by at least two teeth and at most six teeth(region between canines)."	"History of allergy to any of the materials to be used in research
Drugs that could interfere with the oral environment;
Systemic or malignant diseases at the beginning of the study;
Inability to be subjected to specific techniques for performing the experiment not enough space for proper preparation of veneers;
Patients with parafunctional habits;
Patients with periodontitis severe gum inflammation;
Inadequate oral hygiene or high caries rates."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2w7phk	Postoperative vision assessment after changing one of the steps of laser surgery degree correction	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	859	Influence of the change in the shape of the corneal epithelium removal in postoperative visual acuity in photorefractive keratectomy (PRK)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-2w7phk	<NULL>	Volunteers of both gender ; aged between 18 and 50 years; formal indication for bilateral PRK with preoperative visual acuity of 1.0 in both eyes and the difference between the spherical equivalent refractive error of the eye of each less than 1 diopter .	Patients with known or suspected keratoconus ; with cataracts ; people with corneal diseases ; ametropies greater than 8 negative diopters or greater than 4 positive diopters or greater than 4 cylindrical diopters ; people with amblyopia ; people with strabismus, prior eye surgery history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-6s72rf	Analysis of intrastromal corneal ring implants in irregular corneas at a reference center in Brazil	Data analysis completed	Observational	2016-05-23	<NULL>	<NULL>	860	Analysis of intrastromal corneal ring implants in ectatic corneas or presenting secondary irregular astigmatism in a reference center in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo - Departamento de Oftalmologia	Taíse Tognon	https://ensaiosclinicos.gov.br/rg/RBR-6s72rf	<NULL>	"All patients who underwent intrastromal corneal ring implantation between November 2009 and December 2012 in Sorocaba Ophthalmological Hospital.
Surgical technique exclusively manual or using fentosecond LASER assistance.
Patients whose implants used were Kerarings of 5mm diameter."	"Incomplete medical records.
Incomplete ophthalmic preoperative evaluation or incomplete preoperative complementary exames (for example previous corneal topography or tomography and pachymetry)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-524z9n	Contributions to Prenatal Care	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	861	Contributions Theoretical and Practical for Prenatal Care for Diabetic Pregnant	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-02	Universidade Federal do Rio de Janeiro - UFRJ	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-524z9n	<NULL>	adult women ( aged 20 to 49 years), diagnosed with diabetes mellitus prior to pregnancy or during pregnancy with gestational age below 28 weeks and, of singleton pregnancy.	diabetic pregnant women with chronic diseases or diabetes mellitus complications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5jh9sf	Effect of psychological preparation in the preoperative anxiety in children undergoing ambulatory surgery	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	862	Effect of psychological intervention in the preoperative anxiety of preschool children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-06	Faculdade de Medicina de Jundiaí	Faculdade de Medicina de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-5jh9sf	<NULL>	Children of both gender, aged 2-8 years classified as ASA I according to the American Association of anesthesiology, which were attended in the pre-anesthetic assessment clinic of the University Hospital of Jundiaí Medical School and undergoing surgery outpatient at the same hospital.	children with previous surgeries, the ones with confirmed behavioral and cognitive changes, users of psychoactive drugs, patients with history of convulsion, mental illness and chronic pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5t6j5p	Analysis of the effects of vocal training through breath exercises with sound in tube and straw in choir singers	Recruiting	Intervention	2016-05-27	<NULL>	<NULL>	863	Analysis of the effects of vocal conditioning through semi-occluded vocal tract exercises in choir singers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5t6j5p	<NULL>	Age between 18 and 60; score in Voice Sympton Scale (VoiSS) equal to or less than 16; signing of the Informed Consent (IC).	Voice disorders diagnosed by otolaryngologist physician; smokers; presence below 75% in the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2vfhfv	Influence of suplementation of different types of fats on heart health.	Data analysis completed	Intervention	2016-05-27	<NULL>	<NULL>	864	LDL and HDL physical and chemical properties, oxidative and cardiometabolic biomarkers may be modulated by consumption of omega-3, omega-6 and omega-9 in individuals with intermediate cardiovascular risk?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-15	Faculdade de Saúde Pública da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vfhfv	<NULL>	Both sexes, between 30 to 74 years old, medium and high cardiovascular risk.	Malnutrition, prengnancy, previous cardiovascular event, included in other clinical trial, using ilegal drugs, psychiatric alterations, allergic to any compound of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2mmfhx	Effects of the biometenergy of practitioners of meditation on chronic spine pain	Data analysis completed	Intervention	2016-05-27	<NULL>	<NULL>	865	Effects of the biometenergy of practitioners of pranic meditation on the evolution of chronic diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-02	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2mmfhx	<NULL>	Volunteers, both genders, with back pain longer than 3 months, recent medical report, older than 18 years old, no previous participation of pranic meditation courses and no have any knowledge about the techniques of pranic meditation, and the written informed consent	Smokers; alcohol users; pracitioners of pranic meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-8ytcr4	Treatment of Anal and Perianal Condyloma Using Argon Plasma and Electrofulguration in HIV Positive and Negative Patients.	Recruitment completed	Intervention	2016-05-28	<NULL>	<NULL>	866	Treatment of Anal and Perianal Condyloma Using Argon Plasma and Electrofulguration in HIV Positive and Negative Patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Federal de São Paulo-Escola Paulista de Medicina	Eduardo Angelo Braga	https://ensaiosclinicos.gov.br/rg/RBR-8ytcr4	<NULL>	Patients older than 18 years were included ; presence of anal HPV , perianal or both , regardless of whether or not they would have been subjected to prior treatment .	We did not include patients with unilateral condylomatous injury or too large for treatment on an outpatient basis and those who did not agree to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-3jtgfh	Prophylactic antibiotic therapy indicated in reduction mammoplasty: clarifying its role in the prevention of surgical wound infection	Recruiting	Intervention	2016-05-28	<NULL>	<NULL>	867	Effectiveness of antibiotic prophylaxis in a single dose in the infection prevention on reduction mammoplasty surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-10	Hospital Agamenon Magalhaes	Hospital Agamenon Magalhaes	https://ensaiosclinicos.gov.br/rg/RBR-3jtgfh	<NULL>	woman, age from 18 to 70 years old, approved by the hospital medical joint comission; body mass index between 25 to 30	Using steroids ; have used antibiotics in the last 7 days prior to the surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7b7cmn	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	Recruiting	Intervention	2016-05-28	<NULL>	<NULL>	868	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7b7cmn	<NULL>	Candidates must have all the teeth of the upper and lower canine; canine without manifestations of caries and/or restorations; exposed dentin and spontaneous tooth sensitivity; able to sign a consent form; over 18 years; Commit to attend for regular examinations; having good conditions of oral and general health; central incisors to A2 or darker color.	Pacientes who have previously done some bleaching procedure; pregnant or lactating; smokers, patients with tetracycline stains, fluorosis or endodontic treatment; patients with severe periodontitis and bruxists; use of any medication with anti-inflammatory or antioxidant action.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2vmk27	Stability Evaluation and Clinical-Laboratory Study to Verify and Compare Efficay and Safety of Retinoic Acid Cream 0.05% and 5% in Superficial Peels	Recruitment completed	Intervention	2016-01-04	<NULL>	<NULL>	869	Stability Evaluation and Clinical-Laboratory Study to Verify and Compare Efficay and Safety of Retinoic Acid Cream 0.05% and 5% in Superficial Peels	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-21	Universidade Federal de São Paulo	Unidade de Cosmiatria, Cirurgia e Oncologia do Departamento de Dermatologia da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vmk27	<NULL>	Healthy women that past menopause and were not hormone replacement of any kind, over the age of 60; phototypes II and III according to Fitzpatrick&apos;s classification (1988) (Appendix 2); presence of superficial actinic keratoses and multiple through proposed score on the scale of Guimarães (2015) (Appendix 3); agreement to avoid sun exposure throughout the study; agreement with the conditions of study, ability to understand and strictly follow the guidelines received, willingness to attend the regular review and signature of IC (Appendix 1).	Local treatment, except sunscreens, with tretinoin for at least 6 months, other retinoids, alpha-hydroxy acids, polyhydroxy acids, beta-hydroxy acids and ascorbic acid for at least 3 months; previous treatment with oral retinoid in the last 6 months; previous treatment with superficial chemical peels, microdermabrasion and laser non-ablative, for a period not exceeding three months; presence of infectious or inflammatory dermatoses in the upper limbs; chemotherapy in the last three months; clinical evidence of immunosuppression.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-8frjvy	Topical anesthetic&apos;s effectiveness in reducing pain in the puncture needle during anesthesia in the oral cavity: a randomized clinical trial	Recruitment completed	Intervention	2016-05-30	<NULL>	<NULL>	870	The topical anesthetic benzocaine effectiveness evaluation in reducing pain to needle puncture during local anesthesia: study randomized- mouth split	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Centro Universitário Franciscano	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-8frjvy	<NULL>	"Patients over 18 years of age, healthy, with dental history
allergic sensitivity to anesthetic free or their components. The maximum
blood pressure to consider normotensive patients was 139/89 mmHg."	Patients with local and / or systemic change; smokers and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-47hfqm	Hammock position and nesting in premature babies: a comparative study	Data analysis completed	Intervention	2016-05-30	<NULL>	<NULL>	871	Hammock position and nest in premature infants: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-14	Hospital Materno Infantil de Brasília - HMIB	Kassandra Silva Falcão Costa	https://ensaiosclinicos.gov.br/rg/RBR-47hfqm	<NULL>	"Premature babies with post gestational age between 32-37 weeks design;
Spontaneous breathing in room air;
In heated incubator;
Weight between 1300g and 2000g;
Over 72 hours of life;
Hospitalization in the Neonatal Intensive Care Unit more than 24 hours;
Diuresis present and spontaneous;"	"No injury or bone fracture; 
No apnea history less than 72h;
Baby less than 1 hour of applying the study underwent painful invasive procedures such as punctures and polls;
No involvements diagnostics CNS as cerebral hemorrhages, syndromes with neurological impairment, seizure history and hypertension;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-3s3ff7	Effect of pelvic floor muscles training on sexual function of postmenopausal women - Randomized controlled trial	Recruitment completed	Intervention	2016-05-30	<NULL>	<NULL>	872	Effect of pelvic floor muscles training on sexual function of postmenopausal women - Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-24	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-3s3ff7	<NULL>	Women Postmenopausal with a maximum of five years of menopause; Women should have the ability to contract the MAP; having sex, which was defined when there is penetration of the penis into the vagina in the past four weeks; women may not submit diabetes; may not submit thyroid diseases; may not present hyperprolactinemia, may not present genital prolapse (above grade 1)	Women who are intolerant (pain, allergy gel or latex condom or other discomfort) the examination of the MAP function; that denying answer the questionnaires in phases that will be applied.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2q8bzk	The effect of combining breastfeeding plus skin-to-skin contact on the BCG vaccination induced pain in term infants: a randomized clinical trial	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	873	Breastfeeding in skin-to-skin contact in the management of pain during BCG immunization in infants at term : a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-14	Escola de Enfermagem da USP	Hospital Universitário da USP	https://ensaiosclinicos.gov.br/rg/RBR-2q8bzk	<NULL>	The infants who meet the following criteria will be included in the study : Internees in rooming unit; Exclusive breastfeeding without medical records of difficulty to handle and sucking the mother&apos;s womb ; With gestational age between 37 and 41 weeks and 6 days of birth ; Last feed occurring for at least 1 hour before vaccination; BCG vaccination indication; No analgesic use history or sedative; Absence of fractures and tocotraumas ; and absence of nausea or vomiting within the last 2 hours preceding the administration of the BCG vaccine.	Will be excluded from the study newborns who present : Congenital disease diagnosis of the nervous system malformations or neurological damage established after receiving the BCG vaccination; Fracture diagnosis or established tocotraumatism after receiving the BCG vaccine; and application of the vaccine dose or in non-compliance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-5x67ry	Comparison of kinematic variables of gait on a treadmill and on the ground of individuals with Parkinson&apos;s Disease	Recruitment completed	Observational	2016-05-31	<NULL>	<NULL>	874	Comparison of kinematic variables of gait on a treadmill and on the ground of individuals with Parkinson&apos;s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-23	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-5x67ry	<NULL>	Independent walking; not be in pharmacological adaptation phase; no pain, fracture, or serious injury to soft tissues in the 6 months previous to the study; no history of cognitive, respiratory or cardiovascular disorders not controlled; be classified in stages I to III of Hoehn Yahr scale.	Present other neurological diseases than Parkinson&apos;s disease;to present score lower than 24 on the Mini Mental State Examination that will be applied before the collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7dscrq	Volumetric evaluation of the face using three-dimensional technology: study on cadaver	Other	Intervention	2016-05-31	<NULL>	<NULL>	875	Volumetric face reviewed: validation of three-dimensional facial image capture system for structured light technology: study on cadaver	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dscrq	<NULL>	Body to be subjected to autopsy in the Serviço de Óbitos da Capital de São Paulo	Bearded presence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7tnhd8	Characterization of grisp strenth and manul skills of children with 5 to 10 years with Down syndrome.	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	876	Characterization of grisp strenth and manual dexterity of children with 5 to 10 years with Down syndrome.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7tnhd8	<NULL>	"The child must be between 5-10 years and 11 months old; parents have signed a consent form freely Clarified and child Consent Term freely Clarified, the child has a diagnosis of Down syndrome.

The child must be between 5 to 10 years and 11 months old; parents have signed a consent form freely Clarified the child take part in the research by signing the Instrument of Consent Informed freely; the child is typically developing, presenting school grades above average (5.0) in two consecutive marking periods in the subjects of English Language, Mathematics and Physical Education; considered good students for the newsletter description given by school teachers / the classroom, be enrolled and attending regular network of public or private education."	"The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; have different diagnoses of Down syndrome, present co-occurrences of diseases that are not characteristic of Down syndrome according to the guidelines of care for people with Down syndrome (MINISTRY OF HEALTH, 2013).


The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; children have any involvement in its development or have a diagnosis that harms their performance in this study, such as learning disorders, syndromes, cerebral palsy, as well as having a history of prematurity and orthopedic surgeries in the upper limbs and are taking medicine which might jeopardize the manual skill of the child, such as psychotropic drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-5hn7gn	use of minas fresh cheese with probiotics  to control the prevalence of oral candidiasis	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	877	use of probiotics added to minas fresh cheese to control the prevalence of oral candidiasis– double-blind randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-07	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5hn7gn	<NULL>	The inclusion criteria was voluntary patients users of prostheses, with subclinical findings for Candida in the oral cavity; with no evidence or symptoms of candidosis, but who had a positive result of the presence of the fungus after laboratory culture testing. Therefore, the individuals who do not present evidence or symptoms of oral candidiasis but present Candida was included in the research. Age was not be an exclusion factor for individual over 60 years old, even considering the elderly a vulnerable population, since the health conditions required for this group or any other participant was good general health, i.e. none of the subjects of the research can suffer from decompensated diseases, otherwise they were excluded from the research.	The criteria of exclusion was the presence of dementia; hypertensive patients; patients with heart diseases; transplant patients; patients with kidney diseases or those who used any type of medication to treat oral infections or had used antibiotics during the previous month; patients with intestinal complications, such as lactose or dairy products intolerance; patients presenting evidence and symptoms of oral candidosis, who were treated separately with the traditional antifungals nistatina or miconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7x2f4w	Efficacy of an ice popsicle on thirst management in the immediate postoperative period: a randomized clinical trial	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	878	Ice as strategy to the management of thirst in the immediate postoperative period: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-08	Universidade Estadual de Londrina	Hospital Universitário de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7x2f4w	<NULL>	Aged between 18 and 65 years; undergoing more than eight-hour fasting; expressing thirst spontaneously or stimulated with intensity greater than or equal to three;receiving opioids or anticholinergics in the transoperative period; duration of anesthesia exceeding one hour; having been approved in the assessment of the Safety Protocol for Thirst Management	Patients who had intake or swallowing restrictions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-96cjsh	Computer games on elderly socialization	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	879	Virtual Reality games on elderly socialization	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-96cjsh	<NULL>	All the elderly over 60 years, of both sexes, spontaneously enrolled in the informatics beginner class for seniors of the Reference certer of elderly in Ribeirão Pires.	Those who have less than 75% of frequency in the classes between the assessments and/or do not complete the three moments of assessment. Individuals with some motor impairment of the upper limbs, which prevents them to practice the games, will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-4qxt3z	Effect of different forms of electrical stimulation for pain relief in patients with low back pain: a randomized clinical trial	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	880	Effect of different forms of electrical stimulation in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-19	Hospital Universitário (HU) da Universidade Federal de Sergipe (UFS)	CNPq- Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-4qxt3z	<NULL>	Volunteers of both genders; aged between 20 and 55; to have nonspecific low back pain for at least 3 months ago; paid work for at least 8 hours per week	patients performing physical therapy or any other method of treatment, pregnant women or mothers who gave birth in the last 3 months; important deformities and / or amputations of lower limbs (LL); low back pain due to infections; tumors; osteoporosis; rheumatoid arthritis; vertebral fracture; radiculopathy or inflammatory processes; skin lesions in the affected region; and infections assets; other nervous or dermal tissue disease affecting the lower back; surgery or invasive examinations of the spine in the last 3 months; inability to understand the instructions or consent for the study; psychiatric diseases; neurological disorders (eg. stroke; Parkinson&apos;s; Alzheimer&apos;s; brain tumor; dementia; multiple sclerosis; substance abuse) or lung such as chronic obstruction oxygen dependent; which could seriously affect the test results; heart disease such as cardiac arrhythmia; angina pectoris; congestive aca card failure; decompensated hypertension; severe comorbidity; contraindication for the use of electroacupuncture, such wounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-4kkcd7	Evaluation of gingival inflammation after bleaching with hydrogen peroxide in diferente strengths: clinical study randomized	Recruitment completed	Intervention	2016-06-02	<NULL>	<NULL>	881	Evaluation of fluid gingival after bleaching with hydrogen peroxide in diferente strengths: clinical study randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-4kkcd7	<NULL>	Healthy volunteers; aged between 18 and 40; with teeth free of carious lesions; free of periodontal disease; at least an upper anterior tooth color A2 or higher value.	Volunteers with poor oral hygiene; pregnant women; breastfeeding; patients who have already done tooth whitening; smoking; with restorations in anterior teeth; endodontic treatment; dental prosthesis on anterior teeth; presence of dental cracks, gingival recessions; carious cervical lesions; fractures; spontaneous tooth sensitivity; severe internal discoloration; bruxism habits; patients who use drugs with analgesic or anti-inflammatory effect; patients with fixed orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-5n7k99	Effects of a flichart on breastfeeding and exclusive breastfeeding	Recruitment completed	Intervention	2016-06-03	<NULL>	<NULL>	882	Effects of an Educational Technology in self-Efficacy to Breastfeed and Practice of exclusive breastfeeding	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-07	Universidade Federal de Pernambuco	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5n7k99	<NULL>	Pregnant during third trimester; breastfeeding plans; literate; have telephone or cellphone	women with multiple gestations; clinical limitation to breastfeed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7sbzxw	Acupuncture as a complementary treatment for high blood pressure	Recruitment completed	Intervention	2016-06-03	<NULL>	<NULL>	883	Acupuncture as applied technology to nursing Care adult hypertensive: an Experimental Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde Vitória / ES	https://ensaiosclinicos.gov.br/rg/RBR-7sbzxw	<NULL>	Be suffering from essential hypertension exclusively; be properly prescribed medication and have difficulty controlling blood pressure keeping regular measurement above was over 140x90mmHg.	Being pregnant; be in possession of any kind of active neoplasia; being a smoker; be alcoholic; not dieting for weight loss; practice regular physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-283x55	Treatment efficacy for anxiety in obstetric elective procedures	Recruiting	Intervention	2016-06-08	<NULL>	<NULL>	884	Clinical and laboratorial treatment efficacy for general and preoperative anxiety in obstetric elective procedures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-21	Maternidade Escola da Universidade Federal do Rio de Janeiro	Instituto de Psicologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-283x55	<NULL>	pregnant women in 35th gestational week with single normal fetus; with indication for elective obstetric interruption; without  clinical and laboratory complications; normal cardiotocography; obstetric ultrasound without  abnormalities.	use of anxiolytic, sedative or psychoactive drugs;psychiatry disease;previous operative complications;multiple birth;fetal macrossomia;corticotherapy;infection;auricular lesion;high blood pressure symptomatic;gestational diabetes mellitus without control;acuteasthma;active labor;that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-94bvrc	Oral cleaning in intensive care unit patients with photodynamic therapy	Not yet recruiting	Intervention	2016-06-08	<NULL>	<NULL>	885	Oral hygiene in intensive care unit patients  using photodynamic therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-94bvrc	<NULL>	Intensive care unit patient with 0 to 24h oro-tracheal intubation; patients whose family agree with the participation on this study and sign the agreement term; both genders, above 18 years old	Reintubation; readmission in Intensive Care Unit (ICU); smokers and ex-smokers for less than 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-842vr3	Evaluating the effectiveness of bariatric surgeries: Scopinaro modified and classic Scopinaro in treating obesity	Recruitment completed	Intervention	2016-06-14	<NULL>	<NULL>	886	Evaluation of Safety and Effectiveness Scopinaro technique modified the surgical treatment of obesity compared to classical technique Scopinaro	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-07-05	Instituto Paulo Reis de Clínica Cirúrgica e Obesidade Mórbida S/S	Instituto Paulo Reis de Clínica Cirúrgica e Obesidade Mórbida S/S	https://ensaiosclinicos.gov.br/rg/RBR-842vr3	<NULL>	28 participants.Individuals of both sexes. Age between 18 and 65 years. Body Mass Index (BMI)more than 35. Body Mass Index greater than or equal to 40. Be indicated for bariatric surgery after other attempts at treatment. If BMI more than 35 and less than 40 must submit AT LEAST one comorbidity (Type II diabetes or dyslipidemia or hypertension or joint arthropathy in average or great or sleep apnea or hypothyroidism).	Pregnant or breastfeeding.Undergone bariatric surgery révia.Apresentar limiting psychiatric disorders according to the evaluation of especialista.Be user of illegal drugs or alcohol abuse. Be severe disease carrier according to an evaluation specialist. Be severe lung disease carrier according to the evaluation of especialista.Ser of liver cirrhosis carrier. Being active virus carrier(HIV). Has any condition that prevents surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2fvdg2	The Brief Intervention to alcohol related disorders on university servers	Not yet recruiting	Intervention	2016-06-14	<NULL>	<NULL>	887	Effects of Brief Intervention (BI) to alcohol related disorders on university servers: a quantitative and qualitative analysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	(FAPEMIG) - Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Laisa Marcorela Andreoli Sartes	https://ensaiosclinicos.gov.br/rg/RBR-2fvdg2	<NULL>	IT will be included in the study individuals who are over 18, university servers, who accept taking part of it and signing the Agreement and Informed Consentment.	It will defined as non-inclusion criteria for this study people who use other drugs besides than alcohol and tobacco, university professors, outsourced employees who have no permanent position in the institution and individuals unable to answer the questionnaire at the time of reserch application. These individuals will be invited to participate in the survey but they will excluded for data analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7ndc6c	Results of cranial Mobilization in functional Strabismus and craniocervical pain intensity in patients with neck Pain	Recruitment completed	Intervention	2016-06-14	<NULL>	<NULL>	888	Results of Mobilization towards laterolateral direction in the sphenobasilar synchondrosis in the Horizontal Heteroporias and pressure Pain threshould in craniocervical region in patients with Neck Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-06	Hospital Universitário Gaffree e Guinle/HUGG/UNIRIO	Hospital Universitário Gaffree e Guinle/HUGG/UNIRIO	https://ensaiosclinicos.gov.br/rg/RBR-7ndc6c	<NULL>	Volunteers with neck pain; horizontal heterophoria; aged between 18 and 80 years; both sex	volunteers with severe refractive error; strabismus; ocular surgery; Benign paroxysmal positional vertigo; central nervous system diseases; deafness; hearing aids; vascular risk factors; postoperative cervical spine; neoplastic, infectious or inflammatory diseases of the spine; no physiotherapy treatment within the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-7ms62x	Sugammadex in different weights for motor block antagonism of bariatric surgery - clinical trial	Data analysis completed	Intervention	2016-06-14	<NULL>	<NULL>	889	Sugammadex in ideal weight versus weight for reversal of neuromuscular blockade in surgery for treatment of morbid obesity - double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-01-25	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7ms62x	<NULL>	Both genders, age between 18 and 65. BMI greater than or equal to 40 kg m -2, only included after signing the written informed consent	known neuromuscular diseases (eg Miastenis Gravis ) Use of drugs that interfere with the transmission neuromuscularAlergia to some of the drugs used in the study renal failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-2bghmh	Clinical, blood, mobility and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in vibratory platform	Recruiting	Intervention	2016-06-14	<NULL>	<NULL>	890	Clinical, metabolic, functional and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in oscillating / vibratory platform	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Programa de Pós Graduação em Fisiopatologia Clínica e Experimental	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2bghmh	<NULL>	Outpatients both genders; aging over 40 years; of the &quot;Hospital Universitário Pedro Ernesto&quot; (HUPE); with diagnosis of Metabolic Syndrome according the International Diabetes Federation.	Blood pressure higher than 180 x 110 mmHg; Cardiovascular disease in the last 6 months due to heart attack or stroke; Neurological, muscular or rheumatological disease that limit the movements on the oscillating/vibratory platform; Severe or incapacitant clinical disease; Patients that refuse to sign the Agreement Term to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-9qdbh4	Exercises for functionality and balance in elderly	Data analysis completed	Intervention	2016-06-14	<NULL>	<NULL>	891	Multisensory and closed kinetic chain exercises on the functional capacity and balance in elderly women: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9qdbh4	<NULL>	women over the age of 60; understand verbal commands ; without orthopedic surgery of the lower limbs and / or history of fracture ; without walking disability ; without the presence of neurological diseases ; without acute inflammation of the musculoskeletal system ; no cancer	Elderly previously undergone orthopedic surgery of the lower limbs ; with walking disability ; in the presence of neurological diseases ; acute inflammation of the musculoskeletal system ; with cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-7r7t52	Effect of creatine supplementation associated with a program of weight training on muscle mass, strength and physical performance in elderly with reduced muscle mass	Data analysis completed	Intervention	2015-03-02	<NULL>	<NULL>	892	Effect of creatine supplementation associated with resistance training on muscle mass, strength and physical performance in Sarcopenic elderly	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-07-04	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7r7t52	<NULL>	Have between 60 and 80 years of age; Be diagnosed with sarcopenia.	Be vegetarian; Take any ergogenic aid in the last 6 months prior to study initiation; Ingest any medication that can affect muscle growth or the ability to train intensely during the study (statins, muscle relaxants, anti-inflammatory); Be involved in restricting food programs; Be involved in physical training programs; Received contrast or performed radioactive procedure last year; Have any kidney disease, liver disease and heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-8y3sj9	Effectiveness and safety of colchicin crema 0,5% versus photodynamic therapy  in treating areas with precancerous lesions	Recruiting	Intervention	2016-06-16	<NULL>	<NULL>	893	Effectiveness and safety colchicine cream 0,5% versus photodynamic therapy wuith mehtyl aminolevulinate in treatment of skin field cancerization: a randomized clinical trialE	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Faculdade de Medicina - Unesp Botucatu	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8y3sj9	<NULL>	Sign the Statement of Consent. Age above 18 years of both sexes. Provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm.	"Lesions in fewer than three or greater than ten in each forearm.
Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms . 
Current and previous clinical diagnosis or evidence of other diseases .
Display hypersensitivity or allergy to any of subustâncias study . 
Patients using any topical or systemic immunosuppressive substance .
Use of other skin treatment.
Immunocompromised individuals .
Coagulation disorders .
Pregnancy suspected or confirmed.
Women of childbearing potential not using contraception.
Women breast-feeding ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3hzdgv	Monitoring Overweight women by Nursing Telephone Assistance	Not yet recruiting	Intervention	2016-06-16	<NULL>	<NULL>	894	Monitoring of Overweight women by Nursing Remote Assistance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Escola de Enfermagem da Universidade Federal da Bahia	Catia Suely Palmeira	https://ensaiosclinicos.gov.br/rg/RBR-3hzdgv	<NULL>	Women with a body mass index greater than or equal to 25 kg / m2; who have made at least one visit in the last twelve months; and who have home or mobile phone.	Women without physical conditions like amputations for weight and height measurements; with mental confusion; in cognitive conditions that prevent them from responding questionnaires and reading text messages; diagnosed with severe psychiatric disorders; using drugs for weight loss and undergoing bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-2gjxb8	Effects of Cognitive Therapy of motor learning for children with cerebral palsy	Recruitment completed	Intervention	2016-06-16	<NULL>	<NULL>	895	Effects of Cognitive Orientation to daily occupational performance (CO-OP) for children with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-15	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	Ministério da Ciência, Tecnologia e Inovação - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-2gjxb8	<NULL>	Children with cerebral palsy; aged 7 and 14; classified by the Classification System of the Gross Motor Function (GMFCS) levels I or II; sorted by System Manual Function Classification (MACS) in levels I, II and III have cognitive skills to understand commands and verbal communication and attending occupational therapy visits with weekly frequency.	Children who have some visual impairment and / or hearing; children who have been subjected to the use of botulinum toxin and / or orthopedic surgery in the six months preceding the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-5byjd7	Muscle exercises for weak elderly.	Recruiting	Intervention	2016-06-20	<NULL>	<NULL>	896	Resistance training in elderly women with sarcopenia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Ceilândia/ Universidade de Brasília	Faculdade de Ceilândia/ Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5byjd7	<NULL>	Old people, aged oven than 70 years old;  living in the community; retired, who do not perform regular physical activity (use of the IPAQ short version; with availability to participate in all stages of research.	presence of disabling orthopedic disease; current orthopedic disease in the past six months; decompensated blood pressure; sequel of neurological diseases, diabetic; obese (through corporal- mass index BMI); cognitive impairment moderate to severe evaluated by the mini- mental State Examination (MMSE); with moderate to severe depression evidence verified by the Geriatric depression Abbreviated Scale (GDS); in use of nutritional supplements to gain muscle mass or hormone replacement. Also the elderly who miss two consecutive days will be deleted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-7vxcxm	Circular dance effects on quality of life in individuals whom have undergone surgery for intestinal stoma: Randomized Controlled Trial	Recruitment completed	Intervention	2016-05-16	<NULL>	<NULL>	897	Circular dance effects on quality of life in intestinal stomized patients: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-23	Universidade de Brasília - UNB	Hospital Regional de Sobradinho	https://ensaiosclinicos.gov.br/rg/RBR-7vxcxm	<NULL>	Men and women over the age of eighteen (18) years, intestinal ostomy, without participation in any dance form, showing understanding and conditions for continuing the intervention in CERPIS (Reference Center for Integrative Practices in Health), and who agree to participate in the study by signing the Informed Consent.	Children, adolescents, pregnant women, nursing mothers, bedridden, disabled and other patients deficit. Patients undergoing other alternative techniques for management of quality of life, such as meditaion, Yoga, self massage and other practices defined under the National Programme for Integrative and Complementary practices (PNPIC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3rp6tz	Hyperbaric Chamber and Cardiorespiratory Changes	Recruiting	Intervention	2016-06-21	<NULL>	<NULL>	898	Hyperbaric Oxygen Therapy and Cardiorespiratory Changes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3rp6tz	<NULL>	Adults (regardless gender); respiratory and cardiac stability; medical indication to the application of hyperbaric oxygen therapy.	difficulty in understanding and performing the activities; physical and emotional malaise during the pressurization; chest tube; pregnant; hyperthermia; history of seizures not treated; postoperative of head/neck and thoracic surgeries; spherocytosis carriers; claustrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-4k9m6g	Effects of mobilization and muscle strengthening of neck in neck pain	Not yet recruiting	Intervention	2016-06-24	<NULL>	<NULL>	899	Effects of association between Mobilization and Segmental Stabilization Cervical in function, range of motion, and strenght of patients with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4k9m6g	<NULL>	chronic neck pain and cervical radiculopathy; aged 30 to 50 years; and patients signed a free and clarified	patients with cervical spine surgery; concomitant treatment for neck pain; neuromuscular disorders; neurological diseases; pregnant patients; smokers and patients with cognitive problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3w2p32	Comparison of the fake effect among non-penetrating acupuncture devices and real acupuncture	Recruitment completed	Intervention	2016-01-28	<NULL>	<NULL>	900	Comparison of the placebo effect among non-penetrating acupuncture devices and real acupuncture in healthy subjects: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Núcleo de Pós-Graduação em Medicina da Universidade Federal de Sergipe	Hospital Universitário (HU) da Universidade Federal de Sergipe (UFS)	https://ensaiosclinicos.gov.br/rg/RBR-3w2p32	<NULL>	Healthy individuals; both sexes; that and understand Portuguese; no previous experience with acupuncture; without sensitivity to change; which has not undergone surgery in the last 6 months.	Pregnant and postpartum women who gave birth in the last 3 months; prick skin lesions in the region; infectious process assets; nervous or dermal tissue disease affecting the region of the puncture; inability to understand the instructions or consent to the study; psychiatric diseases; presence of hearing impairment, visual or communication; or even have cognitive impairment / moderate or severe psychiatric.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3zv2py	The answer gymnastics in the water	Data analysis completed	Observational	2016-06-28	<NULL>	<NULL>	901	Effects of physical exercises with weights and acquatic on parameters hemodynamic, vascular, metabolic, strength isometric, body image and quality of life during pregnancy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Escola de Educação Fisica e desportos da UFRJ	Escola de Educação Fisica e desportos da UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-3zv2py	<NULL>	Being over 18 years-old;third  trimester gestational; primiparae;answer negatively to all sentences of the Physical Activity Readiness Questionnaire ;normal blood pressure (140 por 90 mmHg) and  permission by the obstetrician to take part in the study.	Women with body mass index (BMI) over 40 kgm-2; those with some sort of musculoskeletal lesion in the past six months; smokers and those using some kind of supplement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-9cph2q	Anxiety in musicians and recognition of the face&apos;s emotions: study about the possible effects of oxytocin.	Not yet recruiting	Intervention	2016-06-29	<NULL>	<NULL>	902	Musical performance anxiety and recognition of facial expressions: clinical randomized study involving the general population and acute effects of oxytocin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Ribeirão Preto - USP	Flávia de Lima Osório	https://ensaiosclinicos.gov.br/rg/RBR-9cph2q	<NULL>	Age above 18 years; Male sex; Professional activities or amadora as a musician, with frequent public presentations at significant audiences.	Neurological and / or psychiatric disorders, excluding anxiety disorders; Renal, pulmonary, hepatic and / or cardiovascular diseases; Current use of tobacco, psychoactive substances and any kind of medication; Harmful alcohol use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-38v67k	Does the protocol  exercises specific can change the movements of the shoulder?	Recruitment completed	Intervention	2016-06-29	<NULL>	<NULL>	903	Does the training of motor control and muscle strengthening could change the scapulotoracic joint kinematic?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-38v67k	<NULL>	Diagnosis of impingement syndrome; scapular dyskinesis present type I or II; aged between 18 and 40 years; history of shoulder pain lasting more than a week; active range of motion the arm 120 degrees.	History of trauma; shoulder surgery; deformity in the thoracic spine; instability; complete rupture of the tendons of the shoulder; pulmonary and heart diseases; neurological diseases; index greater than 28kg / m 2 body weight; reproduction of shoulder pain with radiating pain, numbness or tingling in the arm; systemic disease; perform physical therapy later	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-38mzzg	Effect of treadmill training associated with auditory stimulation on gait and the ability to move of individuals with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-07-01	<NULL>	<NULL>	904	Acute effect of treadmill training associated with auditory stimulation on gait kinematic parameters and functional mobility of individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-38mzzg	<NULL>	Volunteers with Parkinson&apos;s disease; both genders; aged 60 to 85 years; independent walking.	Present other neurological diseases than Parkinson&apos;s disease; be in pharmacological adaptation phase; present pain; present fracture; present serious injury to soft tissues in the six months previous to the study; present history of cognitive, cardiovascular or respiratory changes untreated; not be able to understand verbal instructions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-7ssrwz	Comparison of gait with dual task of healthy elderly and with Parkinson&apos;s disease	Recruitment completed	Observational	2016-07-01	<NULL>	<NULL>	905	Comparison of gait biomechanical variables with dual task of healthy elderly and individuals with Parkinson&apos;s disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-16	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-7ssrwz	<NULL>	Having Parkinson&apos;s disease diagnosis; independent walking; no pain; no fracture; no serious injury to soft tissues in the six months previous to the study; no history of cognitive, cardiovascular or respiratory changes untreated; be able to understand verbal instructions.	Present other neurological diseases than Parkinson&apos;s disease; have less than 60 or older than 85 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-8vkw87	Muscular Electrical Stimulation after Cardiac Surgery	Recruiting	Intervention	2016-07-05	<NULL>	<NULL>	906	Neuromuscular Electrostimulation in the Postoperative of Cardiac Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-21	Universidade Federal de Sergipe	Fundação de Beneficência Hospital de Cirurgia	https://ensaiosclinicos.gov.br/rg/RBR-8vkw87	<NULL>	Will be included in the study cardiac patients of both sexes; aged between 18 and 75 years old who are hospitalized for surgical treatment of Myocardial Revascularization and Valve exchange; being allocated to different groups.	Patients with some type of psychiatric condition; cognitive decline or dementia that could influence the communication process; the presence of musculoskeletal disorder or neuromuscular recent or unresolved that limits or precludes the ability to walk; mobility or functional capacity; hemodynamic instability (Mean Arterial Pressure &lt;60 mmHg or &gt; 120 mm Hg); dyspnea with oxygen saturation less than 90%; tachycardia or bradycardia; cardiac pacemaker carriers; individuals with dermatitis; damaged skin and sensitivity changes that preclude the application of NMES will be deleted from study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-8vvwj8	A clinical study to evaluate the efficacy and safety of Ambrisentan on Pulmonary Arterial Hypertension in patients aged 8 years up to 18 years	Suspended	Intervention	2016-07-05	<NULL>	<NULL>	907	AMB112529 - A randomized, open label study comparing safety and efficacy parameters for a high and a low dose of Ambrisentan (adjusted for body weight) for the treatment of Pulmonary Arterial Hypertension in paediatric patients aged 8 years up to 18 years	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2011-01-04	GlaxoSmithKline	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-8vvwj8	<NULL>	66 Volunteers with diagnosis of Persistent  Pulmonary Arterial Hypertension;  Male or female; at least 8 years of age and not yet 18 years of age	Volunteers currently taking an endothelin receptor antagonist or cyclosporine A and whose body weight is less than 20 Kg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-5cmkth	Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Dacarbazine in Subjects With Soft Tissue Sarcoma	Recruitment completed	Intervention	2016-07-05	<NULL>	<NULL>	908	A Randomized, Open-label, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Dacarbazine in Subjects With Soft Tissue Sarcoma	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2011-03-01	Eisai Inc.	Eisai Inc.	https://ensaiosclinicos.gov.br/rg/RBR-5cmkth	<NULL>	"1.	Histologically confirmed diagnosis of soft tissue sarcoma of high or intermediate grade with one of the following histological subtypes: adipocytic sarcoma; including dedifferentiated, myxoid, round cell and pleomorphic leiomyosarcoma.
2.	Documented evidence of advanced (locally recurrent, locally advanced and/or metastatic) adipocytic (restricted to subtypes listed in Inclusion 1) or leiomyosarcoma, incurable by surgery and/or radiotherapy.
3.	Participants should have received at least two standard systematic regimens for advanced soft tissue sarcoma one of which must have included an anthracycline (unless contraindicated).
4.	Radiographic evidence of disease progression by Response Evaluation Criteria In Solid Tumors (RECIST) criteria on or after the last anti-cancer therapy within the 6 months prior to randomization.
5.	Presence of measurable disease meeting the following criteria:
a.	At least one lesion of greater than or equal to 1.0 centimeter (cm) in long-axis diameter for non-lymph nodes or greater than or equal to 1.5 cm in short-axis diameter for lymph nodes which is serially measurable according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 using either computerized tomography or magnetic resonance imaging or panoramic and close-up color photography. 
b.	Lesions that have had radiotherapy must show evidence of progressive disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 to be deemed a target lesion.
6.	Eastern Cooperative Oncology Group, performance status of 0, 1 or 2.
7.	Adequate renal function defined as calculated creatinine clearance greater than 50 milliliter per minute (mL/min) as per the Cockroft and Gault formula.
8.	Adequate bone marrow function, defined as:
a.	Absolute neutrophil count (ANC) greater than or equal to 1,500/cubic millimeter (mm3) or greater than or equal to 1.5 x 10^9/Liter (L).
b.	Platelet count greater than or equal to 100,000/mm3 or greater than or equal to 100 x 10^9/L.
c.	Hemoglobin (Hb) greater than or equal to 10 grams per deciliter (g/dL) at baseline (blood transfusions, hematopoietic growth factors and hematinics are allowed during the Prerandomization Phase to correct Hb values less than 10g/dL).
9.	Adequate liver function, defined as:
a.	Bilirubin less than or equal to 1.5 times the upper limit of normal (ULN) except for unconjugated hyperbilirubinemia of Gilbert’s syndrome.
b.	Alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) less than or equal to 3 times ULN. For total ALP greater than 3 times ULN, the ALP liver isoenzyme must be less than or equal to 3 times ULN.
10.	All female participants will be considered to be of child-bearing potential unless they are postmenopausal (at least 12 months consecutive amenorrhea, in the appropriate age group and without other known or suspected cause), or have been sterilized surgically (i.e., bilateral tubal ligation greater than or equal to 1 menstrual cycle prior to randomization, or have undergone a hysterectomy and/or bilateral oophorectomy). Female participants of child-bearing potential must agree to use two forms of highly effective contraception from the last menstrual period prior to randomization (or use a double barrier method as described below until they are on two forms of highly effective contraception for at least one menstrual cycle), during the study treatment, and for 3 months after the final dose of study treatment. Female participants exempt from this requirement are participants who practice total abstinence. If currently abstinent, the participant must agree to use a double barrier method of contraception, i.e. condom and occlusive cap (diaphragm or cervical/vault caps) with spermicide or until they are on two forms of highly effective contraception for at least one menstrual cycle if they become sexually active during the study treatment and for 3 months after the final dose of study treatment. Highly effective contraception includes:
a.	Placement of intrauterine device or system.
b.	Barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault cap) with spermicide.
c.	Established hormonal contraceptive methods: oral, injectable or implant. Female participants who are using hormonal contraceptives must have been on a stable dose of the same hormonal contraceptive product from the last menstrual period prior to randomization, and must continue to use the same hormonal contraceptive product during study treatment, and for 3 months after the first dose of study treatment.
d.	Vasectomized partner with confirmed azoospermia.
11.	Male participants and their female partner who are of child-bearing potential (as defined in Inclusion 10), and are not practicing total abstinence, must agree to use two forms of highly effective contraception from the last menstrual period of their female partner prior to randomization (or use a double barrier method as described above until they are on two forms of highly effective contraception for at least one menstrual cycle), during study treatment, and for 3 months (or 6 months if they received dacarbazine) after the final dose of study treatment. If currently abstinent, must agree to use a double barrier method of contraception if they become sexually active, or until they are on two forms of highly effective contraception as described above.
12.	Voluntary agreement to provide written informed consent and the willingness and ability to comply with all aspects of the protocol.
13.	Males or females aged greater than or equal to 18 years at the time of informed consent."	"1.	Participants who have received any anti-cancer therapy, including radiotherapy, cytotoxic, hormonal, biological (including humanized antibodies) and targeted agents within 21 days, or five half-lives of the drug (whichever is longer) prior to randomization.
2.	Participants who have not recovered from acute toxicities as a result of prior anti-cancer therapy to less than or equal to Grade 1, according to Common Terminology Criteria for Adverse Events (CTCAE), except for peripheral neuropathy (see Exclusion 6) and alopecia.
3.	Participants that have previously been treated with dacarbazine or its analogue temozolomide or eribulin.
4.	Major surgery within 21 days prior to randomization.
5.	Pre-existing peripheral neuropathy greater than Common Terminology Criteria for Adverse Events (CTCAE) Grade 2.
6.	Significant cardiovascular impairment, defined as:
a.	Cardiac failure, New York Heart Association (NYHA) Class II according to the NYHA Functional Classification.
b.	Unstable angina or myocardial infarction within 6 months of enrolment.
c.	Serious and potentially life-threatening arrhythmia.
7.	Participants with a high probability of Long QT (Q wave and T wave) Syndrome or QTc (corrected QT) interval prolongation of more than or equal to 501 msec on at least two separate electrocardiograms (ECGs), following correction of any electrolyte imbalance.
8.	Participants with known central nervous system metastases.
9.	Any serious concomitant illness or infectious disease requiring treatment, or infectious disease not requiring treatment, but with significant risks for myelosuppressive complications associated with chemotherapy.
10.	Any malignancy that required treatment, or has shown evidence of recurrence (except for soft tissue sarcoma, non-melanoma skin cancer, or histologically confirmed complete excision of carcinoma in situ) during the 5 years prior to randomization.
11.	Female participants must not be pregnant as documented by a negative beta-human chorionic gonadotropin (beta-hCG) test with a minimum sensitivity 25 international units /Liter (IU/L) or equivalent unit of beta-hCG at Screening and Baseline, or breastfeeding.
12.	Hypersensitivity to the active substance, or any of the excipients of the eribulin drug product, or dacarbazine, (please refer to the dacarbazine prescribing information).
13.	Any medical or other condition which, in the opinion of the principal investigator or designee, will preclude participation in a clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-52hbf7	Comparison of long-term effects of the technique with contraction of the belly muscles and stretching in patients with back pain	Not yet recruiting	Intervention	2016-07-04	<NULL>	<NULL>	909	Comparison of long-term effects of segmental stabilization technique and stretching in patients with low back pain chronic nonspecific	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá - Unifap	Universidade Federal do Amapá - Unifap	https://ensaiosclinicos.gov.br/rg/RBR-52hbf7	<NULL>	For the study are included patients aged 18 to 65 years; patients with a diagnosis of non-specific low back pain with at least three months of progression of pain; patients who signed the informed consent and informed	"Patients pregnant women; patients with specific diagnosis that cause low back pain;
orthopedic, rheumatic and neurological problems; nerve root injury; patients with impaired cognition; patients undergoing treatment during the study period; patient who underwent pre-treatment at least 3 months"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-66xfxh	Yoga exercise for health of the patients with high blood pressure and diabetes	Data analysis completed	Intervention	2016-07-06	<NULL>	<NULL>	910	Yoga exercise for health of the pacients with arterial hypertension and diabetes type II	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-66xfxh	<NULL>	Age between 50 and 75 years; with arterial hypertension light or moderadate; to be under medical and or pharmacological treatment.	Other cardiovascular disease; use of medication bethablockage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-2jmbvt	Clinical performance of two types of dental restorations: atraumatic and conventional	Recruitment completed	Intervention	2016-07-07	<NULL>	<NULL>	911	Randomized clinical trial of Class II ART restorations in deciduous teeth, with and without proximal retentions, and in permanent teeth in comparison with composite resin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-06	Faculdade de Odontologia de Bauru, da Usp	Faculdad de Odontologia Catolica de Córdoba	https://ensaiosclinicos.gov.br/rg/RBR-2jmbvt	<NULL>	"For Hypothesis I the children aged between 4 and 7 year with good general health and having class II cavities in deciduous teeth without pulp involvement or pain will be included.
For Hypothesis II the children aged between 8 and 12year; adolescent and adult between 13 and 44 year with good general health and 1 until 4 class II cavities  in permanent teeth without pulp involvement or pain will be included."	"For Hypothesis I the children presenting behavioral problems; teeth with signs of sepsis, mobility or paranormal occlusion habits and absence of contacts with opposing or neighboring teeth will be excluded.
For Hypothesis II the children; adolescents and adults presenting teeth with signs of sepsis; mobility; more than 4 class II cavities in permanent teeth or paranormal occlusion habits and absence of contacts with opposing or neighboring teeth will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-7w4yjj	Influence of music on anxiety and pulsation, breath and arhterial pressure in patients with head and neck cancer in ambulatory treatment	Recruitment completed	Intervention	2016-07-07	<NULL>	<NULL>	912	Influence of music on anxiety and vitals paramethers in patients with head and neck cancer in ambulatory treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio - HUWC	https://ensaiosclinicos.gov.br/rg/RBR-7w4yjj	<NULL>	Patients who are in attendance for the CCP, whether in post surgical middle period; undergoing chemotherapy or radiotherapy; patients older than 18 years; literate patients; patients with scores on the Glasgow scale equal to 15; patients who are not making use of anxiolytic medications; patients who have preserved hearing acuity.	"possuam thyroid cancer; in palliative treatment; use of anxiolytics in the period up to 24 hours prior to application
music; Patients who are not literate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-9f7fpw	Analysis of body balance and muscle activity before and after reconstruction of the anterior cruciate ligament (acl)	Recruitment completed	Intervention	2016-05-30	<NULL>	<NULL>	913	Analysis of body oscillation and myoelectric activity before and after reconstruction of ACL (anterior cruciate ligament)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-23	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9f7fpw	<NULL>	"Complete unilateral ACL injury (anterior drawer and Lachman + MRI); 
Prediction of surgical reconstruction and have no other clinical finding of dysfunction or injury in the affected limb; 
Do not submit ligament or joint injury in the lower limb or contralateral vestibular and / or neurological dysfunction."	Failure to attend one of the reviews; Interruption of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-9z8my4	Comparison of two surgical techniques of fissure filling with synthetic bone in patients with cleft lip	Recruitment completed	Intervention	2016-07-11	<NULL>	<NULL>	914	Comparison of two techniques of surgical access for alveolar bone grafting in patients with cleft lip and palate	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-18	Coordenação de aperfeiçoamento de pessoal de nível superior	Hospital de reabilitação de anomalias craniofaciais	https://ensaiosclinicos.gov.br/rg/RBR-9z8my4	<NULL>	Age between 9 and 20 years; Indication for secondary or tertiary unilateral alveolar bone graft; Satisfactory oral hygiene; Absence of periodontal disease and probing depth 3 mm or less in the examined sites; Absence of bone resorption and; Amount of keratinized tissue in the anterior maxilla of at least 2 mm (Lang and Löe 1972).	Smokers; Anticonvulsant, anticoagulants or anti-inflammatory drugs; Systemic diseases and craniofacial syndromes; Presence of prosthetic reconstruction in anterior and upper teeth; Absence of teeth adjacent to the alveolar cleft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-823rst	Evaluation of application, safety and motor and cognitive effects of video game Nitendo Wii Fit Plus® in frail elderly	Recruiting	Intervention	2016-07-11	<NULL>	<NULL>	915	Evaluation of applicability, safety and outcomes motor and cognitive of video game Nitendo Wii Fit Plus® in frail elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-823rst	<NULL>	Frail elderly and pre frail will be selected with 60 or older, diagnosed with frailty syndrome according to the criteria of Fried. The elderly should not present neurological or orthopedic diseases that promote the inability to remain in bipedalism and wade; with normal or corrected visual acuity measured by Snellen chart; Good hearing is clinically assessed by the whisper of the test; who did not have previous experience with the Nintendo Wii Fit® and who accept sign the Informed Consent and Informed of the study.	The elderly will be excluded that during the study period, submit any clinical change that makes it impossible to perform physical exercises in standing position, as cardiorespiratory, orthopedic or neurological disorders; elderly unable to interact with the game; and in the second phase of the study will exclude elderly who are missing for more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-4rxr2c	Gabapentin and dexclorfeniramine in the treatment of pruritus in hemodialysis patients	Recruitment completed	Intervention	2016-07-11	<NULL>	<NULL>	916	Gabapentin versus dexclorfeniramine in the treatment of uremic pruritus in hemodialysis patients: a randomized clinical trial, double-blind and controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-21	Faculdade de Medicina de Botucatu	Fundo de Apoio à Dermatologia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4rxr2c	<NULL>	Sign the consent form; Age above 18 years, of both genders; chronic renal insufficiency stage 5 on hemodialysis for at least 3 months; persistent pruritus of any intensity that occurs at least three times per week with a duration of 30 days or more; no use of topical antipruritic medications and / or systemic at least one week before start of study	"Chronic skin diseases (allergic, infectious and parasitic); Chronic liver disease; Internal malignant disease; Use of opioids, antihistamines or corticosteroids.
the participants Will be discontinued if: withdrawal of consent; using other treatments for pruritus not recommended in this protocol and serious adverse events"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-472gf3	Evaluation of the use of ketamine medication in the treatment of depressed or bipolar persons	Recruiting	Intervention	2016-07-11	<NULL>	<NULL>	917	Sublingual Ketamine in treatment of Mood Disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Hospital São José	Hospital São José	https://ensaiosclinicos.gov.br/rg/RBR-472gf3	<NULL>	Volunteers who have any mood disorders and high risk of suicide; 16-59 years old.	Volunteers manifesting delusions or maniac symptoms to mental status examination or BPRS; an actual history of alcohol or substance dependence with recent use in the last 7 days except nicotine and benzodiazepines; an unstable or untreated medical disorder; severe exogenous intoxication; being pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-59bm68	Evaluation of a recipe made with leaves and stalks of beet and its effect on oxidative stress and fat levels in the blood after a meal in patients with dyslipidaemia	Recruitment completed	Intervention	2016-07-12	<NULL>	<NULL>	918	Biochemical and sensory analysis of a preparation made with beet leaves and stalks and evaluate its effect on oxidative stress and postprandial lipemia in dyslipidemic subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-59bm68	<NULL>	15 Dyslipidemic volunteers; both genders; aged 20 to 60 years; non smokers.	Voluntiers in insulin use; diagnosis of diabetes mellitus; kidney disease; liver or thyroid disorders; Patients undergoing treatment for weight control; pregnant women; nursing mothers; menopausal women; women on hormone replacement; smoking; on medication for dyslipidemia control; history of a cardiovascular event in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-4sxpff	CTT116855 Twelve month study to compare three investigational medications in patients with chronic obstructive pulmonary disease who have a history of COPD exacerbation	Recruitment completed	Intervention	2016-07-05	<NULL>	<NULL>	919	CTT116855 A phase III, 52 week, randomized, double-blind, 3-arm parallel group study, comparing the efficacy, safety and tolerability of the fixed dose triple combination FF/UMEC/VI with the fixed dose dual combinations of FF/VI and UMEC/VI, all administered once-daily in the morning via a dry powder inhaler in subjects with chronic obstructive pulmonary disease	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-06-30	GlaxoSmithKline	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4sxpff	<NULL>	Subjects with at least 40 years old with history of cronic obstructive pulmonary disease and also smoking history; that is currently receiving cronic treatment for cronic obstructive pulmonary disease and have history of exacerbations	Pregnancy or lactating women; subjects with asthma diagnostics or other respiratory disorders; hepatic unstable  disease or cardiopaty unstrable; others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-3v6pmy	Creating a new program of exercise for heart disease	Recruitment completed	Intervention	2016-07-12	<NULL>	<NULL>	920	Creation of a new method of exercise prescription for phase II of the cardiac rehabilitationprogram   for patients with coronary artery disease (first protocol)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Pontificia Universidade Catolica do Paraná	Hospital cardiológico costantini	https://ensaiosclinicos.gov.br/rg/RBR-3v6pmy	<NULL>	coronariophatic patients with ischemic scintigraphy; transluminal coronary angioplasty; acute myocardial postinfarction; with left ventricular ejection fraction &lt; 50% (assessed by transthoracic echocardiography) and stratified as low or moderate risk for the practical exercises according to AACRP.	muscle or osteoarticulars lesions induzed by exercise; failure to comply with the 36 sessions of the program or cardiovascular events that prevented the permanence in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-5pw27c	Intervention mental health needs in the community	Recruitment completed	Intervention	2016-01-06	<NULL>	<NULL>	921	Identification of needs and proposed intervention in mental health problems and use of psychoactive drugs in user population of the Family Health Program (PSF)in Ribeirão Preto / SP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5pw27c	<NULL>	23 Volunteers of both genders; not hospitalized during the operation; 18+; alcohol users in harmful pattern observed after application of the AUDIT instrument. For the relatives of users, plus the need of not harmful use of alcohol.	Hospitalized volunteers for data collection; who are undergoing treatment for alcohol; that are not available to participate in all stages of the study; children under 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-9dgk5r	Aquatic therapy on muscle strenght and quality of life in elderly women	Recruitment completed	Intervention	2016-07-14	<NULL>	<NULL>	922	The influence of aquatic physical therapy program on muscle srenght and quality of life in elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-10	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9dgk5r	<NULL>	Volunteers aged over 60 years; that did not show any functional impairment and cardiorespiratory disease that is restrictive for the implementation of the program of aquatic exercise.Additionally, the volunteers should not participate in other programs of regular exercise.	Volunteers who present  the following contraindications for aquatic exercise program; otitis; hydrophobia; sores on the skin; mycoses and hypertension stage III.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-3nkwyv	Evaluation of adults that gnash their teeth before and after using appliance	Recruitment completed	Intervention	2016-07-14	<NULL>	<NULL>	923	Evaluation of the effect of occlusal splint use on the bite force, quality of sleep and salivary cortisol levels in subjects with sleep bruxism	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia de Piracicaba (UNICAMP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-3nkwyv	<NULL>	Adults; age ranging from 20 to 40 years; Caucasians; students or employees of the Universidade Comunitária da Região de Chapecó (Chapecó, Brazil).	Systemic disturbances which could compromise the evaluation of the stomatognathic system; neurological disorders; epilepsy; cerebral palsy; presence of systemic diseases or medication use that could interfere with muscle or salivary activity directly or indirectly; hypertension; cancer; rheumatoid arthritis; diabetes; dyslipidemia; xerostomia; use of antihistamine; use of benzodiazepines; use of antidepressants; use of anxiolytics; use of syrups; use of anti-inflammatory; use of corticoids; use of homeopathy; inappropriate behavior and/or refusal to cooperate in dental procedures and evaluation of the proposed variables.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-2gykb2	Effects of clown intervention on the psychological stress and fatigue in children and adolescents with cancer receiving chemotherapy	Recruiting	Intervention	2016-07-14	<NULL>	<NULL>	924	Correlations between immunological biomarkers and response to fatigue and psychological stress in children and adolescents with cancer undergoing chemotherapy submitted to clown intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-12	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gykb2	<NULL>	Experimental group;Children and adolescents aged 2 to 18 years; of both sexes; diagnosed with malignant neoplasm; in any phase of chemotherapy; who present conscious, able to communicate verbally, reading and writing; Control group;Children and adolescents aged 2 to 18 years; with no history of chronic disease or autoimmune disease or psychiatric illness; followed up in one of the 5 Family Health Unitis; not be receiving medication at the time of selection or collection of biological samples; who present conscious, able to communicate verbally, reading and writing; presenting recent blood count data in normal levels;	Experimental group;Patients with a history of chronic disease or autoimmune disease or psychiatric disease; patients receiving radiotherapy; patients in palliative care; patients using antidepressants or drugs which altering the mood; patients with clownfobia; patients with infectious conditions in activity; patients in the immediate postoperative period; Control group;Children and adolescents with infectious conditions in course; presence of fever in the last 48 hours; in use of systemic corticosteroids, inhaled or topical in the last 15 days;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-2st594	Integrated design : characterization of children with neurological disorders who perform physiotherapy	Not yet recruiting	Intervention	2016-07-15	<NULL>	<NULL>	925	Integrated design: user characterization and effects of neuromotor intensive therapy  and aquatic physical therapy in children with neuromotor disorders	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-14	Universidade Federal do Paraná	Instituto Brasileiro de Therapias e Ensino (IBRATE)	https://ensaiosclinicos.gov.br/rg/RBR-2st594	<NULL>	clinical diagnosis of pathology that causes motor neurone disorder such as cerebral palsy syndromes or delays in motor development ; medical indication for the procedure; age 0-18 years; both sexes ; with consent by parents and / or family	subluxation of the hip ; acute fractures ; severe scoliosis ; uncontrolled seizures ; serious intellectual delay ; spasticity with severe angle &gt; 35; contractures or other congenital deformities ; intrathecal baclofen pump ; autism; encephalopathies progressive , psychiatric disorders ; myopathies ; Botox use with time of less than 3 months and surgeries with time less than 1 year ; for patients who will be added to the aquatic therapy earlier , lack of sphincter control ; injuries and / or skin disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-3m6cny	Comparative efficacy and safety study of dolutegravir and lopinavir/ritonavir in second-line treatment	Recruitment completed	Intervention	2016-02-22	<NULL>	<NULL>	926	"200304 - A phase 3b,randomised,open-label study of the antiviral activity and safety of dolutegravir compared to lopinavir/ritonavir both administered with dual nucleoside reverse transcriptase inhibitor therapy in HIV-1 (Type I virus of acquired immunodeficiency syndrome) infected adult
subjects with treatment failure on first line therapy"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-07-29	ViiV Healthcare	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-3m6cny	<NULL>	"HIV-1 infected subjects greater or equal to 18 years of age;

A female subject may be eligible to enter and participate in the study if she: is of non-childbearing potential defined as either post-menopausal (12 months of spontaneous amenorrhea and greater or equal to 45 years of age) or physically incapable of becoming pregnant with documented tubal ligation, hysterectomy, or bilateral oophorectomy or, is of child-bearing potential, with a negative pregnancy test at both screening and day 1 and agrees to use one of the protocol-defined methods of contraception to avoid pregnancy;

HIV-1 infection as documented by HIV-1 RNA greater or equal than 400 c/mL at screening; subject has been on a first-line treatment regimen consisting of an NNRTI plus two NRTIs for at least 6 months and is currently experiencing virologic failure to this first-line regimen defined as two consecutive (greater or equal to 7 days apart) HIV-1 RNA results of greater or equal to 400 c/mL; subjects must receive at least one fully active agent within the dual-NRTI background regimen for second line treatment; fully active is defined by the screening genotypic resistance report of the central laboratory (or a laboratory contracted by the central laboratory) showing no evidence of full or of partial resistance for a given NRTI which will be taken on study; subject is PI-naïve and Integrase inhibitor (INI)-naïve, defined as no prior or current exposure to any PI or INI; subject or the subject&apos;s legal representative is willing and able to understand and provide signed and dated written informed consent prior to screening"	Women who are breastfeeding;  any evidence of an active Centers for Disease Control and Prevention (CDC) Category C disease exceptions include cutaneous Kaposi&apos;s sarcoma not requiring systemic therapy and historic or current CD4+ cell levels less than 200 cells per cubic millimeter; subjects with severe hepatic impairment, class C, as determined by Child-Pugh classification; unstable liver disease, as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, oesophageal or gastric varices, or persistent jaundice, cirrhosis, known biliary abnormalities, with the exception of Gilbert&apos;s syndrome or asymptomatic gallstones; anticipated need for hepatitis C virus, HCV, therapy during the randomised phase of the study; history or presence of allergy or intolerance to the study drugs or their components or drugs of their class; ongoing malignancy other than cutaneous Kaposi&apos;s sarcoma, basal cell carcinoma, or resected, non-invasive cutaneous squamous cell carcinoma, or cervical intraepithelial neoplasia; other localised malignancies require agreement between the investigator and the study medical monitor for inclusion of the subject; subjects who in the investigator&apos;s judgment, poses a significant suicidality risk. Recent history of suicidal behaviour and/or suicidal ideation may be considered as evidence of serious suicide risk; treatment with an HIV-1 immunotherapeutic vaccine within 90 days of screening; treatment with any of the following agents within 28 days of screening: radiation therapy, cytotoxic chemotherapeutic agents, systemically administered immunomodulators; treatment with any agent, other than licensed ART as allowed above with documented activity against HIV-1 in vitro/vivo within 28 days of first dose of investigational product. The exception is use of entecavir, in appropriate clinical situations, for treatment of hepatitis B, e.g. prior intolerance to Tenofovir, viral resistance to lamivudine (3TC)/Emtricitabine (FTC),  after discussion and agreement between the investigator and the medical monitor; exposure to an experimental drug or experimental vaccine within either 28 days, 5 half-lives of the test agent, or twice the duration of the biological effect of the test agent, whichever is longer, prior to the first dose of investigational product; any evidence of primary viral resistance to protease inhibitors or integrase inhbitors based on the presence of any major resistance-associated mutation; the subject&apos;s virus does not yield results using genotype at screening, assay data is essential for eligibility determination; any verified grade 4 laboratory abnormality, with the exception of grade 4 triglycerides. A single repeat test is allowed during the screening period to verify a result; any acute laboratory abnormality at screening, which, in the opinion of the investigator, would preclude the subject&apos;s participation in the study of an investigational compound; alanine aminotransferase, ALT, greater or equal than 5 times the upper limit of normal, ULN, or ALT greater or equal than 3xULN and bilirubin greater or equal than 1.5xULN (with more than 35% direct bilirubin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-5qs9gr	Study in Matão to prevent Stroke: preventing Stroke in city of Matão, Brazil	Recruiting	Observational	2016-07-18	<NULL>	<NULL>	927	Mapa: Stroke prevention in Matão	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Sociedade Matonense de Benemerência	Centro Neurológico de Pesquisa e Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-5qs9gr	<NULL>	All first ever stroke patients aged,  aged older than 18 years old; residents in Matão city.	Subjects living in other localities;  subjects with previous stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-39tqqq	Immediate influence of podal elements of postural insoles over weight bearing, balance and posture	Recruitment completed	Intervention	2016-07-18	<NULL>	<NULL>	928	Analysis of immediate influence of podal elements of proprioceptive insolves on the human posture	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-27	Universidade Federal de Goiás Faculdade de Medicina	Universidade Federal de Goiás Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-39tqqq	<NULL>	Adults between 20 and 40 years of age; able to remain in the standing position without support; without musculoskeletal pain complaints at the moment of evaluation; with assimetries of  shoulder ande pelvic girdle; able to understand  and agree with the informed consent.	Individuals with neurological sequelae (resulting from stroke, head trauma and other neurological diseases); reporting symptoms of vertigo or dizziness; pregnant women; individuals who have performed surgery on the spine or feet; presence of diabetic or varicose ulcers on the feet; full or partial amputation of limbs; presence of some kind of visual impairment; individuals who are being treated with therapeutic insoles; difference in length of lower limbs greater than 5mm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-4ykn3p	Quality of life of people with eye disease elevated intraocular pressure and knowledge about the disease before and after practice health education	Not yet recruiting	Intervention	2016-07-18	<NULL>	<NULL>	929	Glaucomatous life quality and knowledge about the disease before and after practice health education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Unimontes	Santa Casa Olhos de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-4ykn3p	<NULL>	glaucomatous with 40% accuracy in disease knowledge questionnaire; reside in Montes Claros; both genders; aged between 18 and 70 years.	glaucomatous unable to answer an evaluation questionnaire of knowledge about the disease; mental impairment with cognitive impairment; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-9djsc7	Association between vestibular rehabilitation treatments for dizziness	Recruiting	Intervention	2016-07-19	<NULL>	<NULL>	930	Vestibular rehabilitation protocols association: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal de Pernambuco	Hospital Agamenon Magalhães	https://ensaiosclinicos.gov.br/rg/RBR-9djsc7	<NULL>	Elderly both genders with vestibular complaints; aged between 60 and 80 years; hospital patients.	Seniors who underwent audiometry and vectoelectronystagmography; Elderly patients with vestibular complaints; seniors who are not embedded in vestibular rehabilitation program; do not have hearing loss and or hearing aids; noncarriers of psychiatric disorders; They do not have physical disabilities; wheelchair; amputees; do not use crutches; participants visual impairment grave; Elderly unable to understand verbal commands; elderly diagnosed with benign paroxysmal vertigo;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-8g42hq	Factors Associated With Abdominal Pain in Patients Submitted to Colonoscopy	Data analysis completed	Observational	2016-07-19	<NULL>	<NULL>	931	Evaluation Factors Associated With Abdominal Pain in Patients Submitted to Colonoscopy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8g42hq	<NULL>	patients of both genders; patients who underwent colonoscopy exam	patients who underwent urgent examination; patients who require deep sedation; patients with incomplete records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-8xttkv	Effect of stimulation of the senses in the head control in children with cerebral palsy	Recruiting	Intervention	2016-07-20	<NULL>	<NULL>	932	Influence of sensory stimulation in the head control in children with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Educação Física/ Universidade de Brasília	Hospital da Criança de Brasília José Alencar	https://ensaiosclinicos.gov.br/rg/RBR-8xttkv	<NULL>	Children diagnosed with cerebral palsy classified V level Gross Motor Functional Classification System - GMFCS, aged 9 and 36 months.	1) Children who completed 36 months before the final evaluation; 2) associated syndromes; 3) seizures outside clinical control; 4) structural musculoskeletal deformities preventing the execution of motor intervention; 5) Total visual impairment; 6) hearing loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-64b7x7	Music influence on anxiety, blood pressure, heart and respiratory rate in chronic renal failure patients on hemodialysis	Recruitment completed	Intervention	2016-07-21	<NULL>	<NULL>	933	Music influence on anxiety and parameters vital chronic renal patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-64b7x7	<NULL>	Patients who perform dialysis therapy; over the age of 18; Literate patients;with scores on the Glasgow scale 15 and who had preserved hearing acuity.	Be used anxiolytics in the period up to 24 hours prior to application of music.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-8x8fd9	Low sugar diet combined with nasal administration of perillyl alcohol: strategy therapy for resistant Glioblastoma Multiforme  to chemotherapy and radiotherapy	Recruiting	Intervention	2016-07-21	<NULL>	<NULL>	934	Ketogenic diet combined with intranasal administration of perillyl alcohol: strategy therapy to refractory Glioblastoma Multiforme  to standard treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-05	Hospital Universitário Antônio Pedro	Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-8x8fd9	<NULL>	Men and women with recurrent glioblastoma multiforme; aged 20 to 65; standard therapy (chemotherapy and/or radiotherapy); inhalating perillyl alcohol.	Patients with neurological complications; terminal phase; discontinue diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-75n6gm	Influence of a weight loss nutritional counselling program on cardiovascular diseease risk factors and the role of adipose tissue hormones on weight maintenance and regain	Recruitment completed	Intervention	2016-07-22	<NULL>	<NULL>	935	Influence of a weight loss nutritional counselling program on cardiometabolic profile and the role of adipokines on weight maintenance and regain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Hospital Universitário da Universidade de São Paulo	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75n6gm	<NULL>	Adults (aged 20 to 59 years), both sexes, BMI of at least 25 kg/m2, who have read and signed the written informed consent. The subjects must attend at least 4 of the 5 group meetings.	Participation in other interventional studies; use of weight loss medication; use of illicit drugs; alcoholics; pregnancy or breastfeeding; upper and lower limb amputation; practice of high intensity physical activity; surgical procedures that may influence body weight 3 months prior and/or during the intervention and follow-up period; critical chronic and acute diseases that limit life expectancy in 6 months. Information regarding inclusion and exclusion criteria will be obtained from personal interview and medical records.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-47fqzk	Effects of Counseling in sedentary adults with ankylosing spondylitis	Recruiting	Intervention	2016-07-22	<NULL>	<NULL>	936	Evaluation of effects hacer sin Sedentary behavior counseling Adults with ankylosing spondylitis : a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-47fqzk	<NULL>	"Having diagnosis of ankylosing spondylitis, according to the criteria New York.
Age between 18 and 59 years.
Male."	"Be diagnosed with some form of physical or mental disability.
Patients on medications that alter bone metabolism , such as denosumab , teriparatide , strontium ranelate.
Patients with bone fracture history in the last 6 months.
Patients with metabolic bone diseases and / or diseases that alter bone metabolism , including hyperparathyroidism , chronic renal failure , metabolic acidosis and alteration of serious levels of calcium, phosphorus and magnesium. 
Patient presenting chronic decompensated and medical negative for physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-7t8fv7	Clinical trial of the effectiveness of telephone nursing care to individuals with inflammatory bowel disease	Not yet recruiting	Intervention	2016-07-25	<NULL>	<NULL>	937	The telenursing in the treatment of inflammatory bowel diseases: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7t8fv7	<NULL>	volunteer with Crohn disease in remission and light activity; volunteer with ulcerative colitis in remission and light activity; both genders; aged between 18 and 60 years.	volunteers with cognitive disorder; volunteers without acess to phone; volunteers with special needs that preclude the telenurssing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-4f253v	Effect of training with exercises using movements from day to day on anthropometry, functional capacity and blood glucose elderly with diabetes	Recruitment completed	Intervention	2016-07-27	<NULL>	<NULL>	938	Effect of functional training on anthropometric parameters, functional and glycemic elderly with diabetes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-09	Universidade do Sagrado Coração	Conselho Nacional de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4f253v	<NULL>	Elderly, above 60 years, with type 2 diabetes; both sexes; with prior medical evaluation; whithout physical exercises for at least three months.	Health problems and / or orthopedic limitations that contraindication to practice the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6dmh7d	Deep Water Running in reducing body weight, improved functional capacity and quality of life in obese	Recruiting	Intervention	2016-07-27	<NULL>	<NULL>	939	Effect of Deep Water Running in body composition, functional capacity and quality of life in pre-obese and obese adults: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-6dmh7d	<NULL>	Volunteers of both sexes; adults in the age group of 39 to 59 years of age; classified as pre-obese  and obesity I  according to the III Brazilian Guidelines on Obesity. Show good adaptation to the liquid medium; perform the entry; exit and walking in the pool independently, and adequately perform the Deep Water Running technique in interval training system (DWR-STI). All volunteers must submit prescription attesting to the absence of restrictive heart disease the practice of aquatic physical training.	"cardiorespiratory, musculoskeletal and neuromuscular diseases that impede the realization of the aquatic training program; as well as the following contraindications of aquatic physical therapy; hydrophobia; skin wounds and infectious diseases.
Volunteers may not have taken part in other physical training program for at least two months before the start of data collection, as well as carrying out other training or nutritional monitoring program for the aquatic intervention.
For those who use antihypertensive medications and therapy for hormone replacement therapy (HRT); will not be allowed to change in class and or drug dose. Each volunteer can have a maximum of 3 absences (10%) nonconsecutive during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-3fgtdp	Administration of drugs intramuscular:  in the buttocks region and the side region of the hip	Recruitment completed	Intervention	2016-07-27	<NULL>	<NULL>	940	Administration of drugs intramuscular:  dorsogluteal  region and  the ventrogluteal region	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-02	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3fgtdp	<NULL>	Active syphilis diagnosis; prescription of Penicillin G Benzatina, intramuscular, for treatment of syphilis; without alterations at the site of injections.	"Allergic to Penicillin G Benzatina;
bedridden; paraplegics; decreased level of consciousness; fear of injection; painful sensation absent or decreased."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6j6fcx	Patients who require more tube at the oral region, to breathe after heart surgery	Recruitment completed	Observational	2016-07-27	<NULL>	<NULL>	941	Risk factors for intubation in patients after cardiac surgery.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-05-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6j6fcx	<NULL>	Patients of both genres; oldee of 14-80 years; individuals who underwent heart surgery; in the intensive care unit; under mechanical ventilation; endotracheal intubation and daily evaluation by the nursing staff.	Patients undergoing cardiac procedures in the analyzed period; but were not forwarded to postoperative ICU or had incomplete information in the database were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-7sm6qj	The use of educational game as a strategy to confront the childhood obesity	Not yet recruiting	Intervention	2016-07-27	<NULL>	<NULL>	942	"The use of serious games as a strategy to confront the childhood obesity:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-30	Escola de Educação Física e Esporte de Ribeirão Preto	Escola Enfermagem de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7sm6qj	<NULL>	aged 8-14 years; with body mass index (BMI) percentile 85; allowed to play video games; who can read; that are being followed in an outpatient clinic obesity.	with Diabetes Mellitus or celiac disease; who have arthritis; that have hormonal dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-2x96t2	healing wounds evaluation in patients with sickle cell anemia	Recruitment completed	Intervention	2016-07-28	<NULL>	<NULL>	943	Evaluation of ulcer healing process in patients with sickle cell anemia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2x96t2	<NULL>	To be registered and regularly attend multidisciplinary outpatient healing of HU / UFS; be older than 12 years; ulcers present in one or both members; being a carrier of sickle cell anemia.	Patient&apos;s refusal to participate in the study; avoidance of multidisciplinary healing clinic; have insufficient cognitive conditions to follow the recommended guidelines; present peripheral arterial disease or autoimmune disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-48zmp6	TAF116564 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria	Recruitment completed	Intervention	2016-07-28	<NULL>	<NULL>	944	TAF116567 A randomized, double blind, double dummy, comparative, multicenter study to assess the incidence of hemolysis, safety, and efficacy of tafenoquine (sb252263, wr238605) versus primaquine in the treatment of subjects with plasmodium vivax malaria	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-01-18	GlaxoSmithKline	Medicines for Malaria Venture	https://ensaiosclinicos.gov.br/rg/RBR-48zmp6	<NULL>	"A female is eligible to enter and participate in the study if she is non pregnant, nonlactating and if she is of a: non-childbearing potential defined as post-menopausal (12 months of spontaneous amenorrhea or  less than 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone greater than 40 milli-international units per milliliter, or pre-menopausal and has had a hysterectomy or a bilateral oophorectomy (removal of the ovaries) or a bilateral tubal ligation, negative pregnancy test or, b. child-bearing potential, has a negative pregnancy test at screening, and agrees to comply with one of the following during the treatment stage of the study and for a period of 90 days after stopping study medication: use of oral contraceptive, either combined or progestogen alone used in conjunction with double barrier method as defined below. Use of an intrauterine device with a documented failure rate of  less than 1% per year; use of depo provera injection; double barrier method consisting of spermicide with either condom or diaphragm; male partner who is sterile prior to the female subject&apos;s entry into the study and is the sole sexual partner for that female. Complete abstinence from intercourse for 2 weeks prior to administration of study medication, throughout the study and for a period of 90 days after stopping study medication.
The subject has a glucose 6-phosphate dehydrogenase (G6PD) value (measured by a quantitative spectrophotometric phenotype assay) as follows: female subjects must have an enzyme level greater or equal than 40 percent of the site median value for G6PD normal males. Male subjects must have an enzyme level greater or equal than 70 percent of the site median value for G6PD normal males.
The subject has a screening hemoglobin (Hb) value as follows: any subject with a G6PD value greater or equal than 70 percent of the site median value must have a screening Hb value greater or equal than 7 g/dL; female subjects with a G6PD value is greater or equal than 40 -  less than 70 percent of the site median value must have a screening Hb value greater or equal than 8 g/dL.
The subject has a qt duration corrected for heart rate by fridericia&apos;s formula (QTcF) less than 450 milisecond (msec). Reading based on an average of triplicate electrocardiograms (ECGs) obtained over a brief recording period by machine or manual over-read. The subject has a positive malarial smear for P. vivax.The subject has a parasite density of greater than 100 and less than 100,000 per microliter (?L). Male or female subject aged 16 years or older at the time of signing the informed consent. The subject agrees to G6PD genotyping. The subject is willing and able to comply with the study protocol. The subject or parent/legal guardian, as applicable, has given written informed, dated consent; and the subject has given written assent, if applicable, to participate in the study."	Mixed malaria infectio; severe P. vivax malaria as defined by world health organization criteria, history of allergy to chloroquine, mefloquine, tafenoquine, primaquine, or to any other 4- or 8-aminoquinoline; liver alanine aminotransferase (ALT) greater than 2 time the upper limit of normal; severe vomiting , condition that may affect absorption of study medication (e.g., vomiting, severe diarrhea), or clinical signs and symptoms of severe cardiovascular disease; history of porphyria, psoriasis, or epilepsy; history of significant ocular disease or evidence of corneal or retinal abnormalities identified in the clinical ophthalmologic examination,	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-2kw6p9	Use of equine therapy to improve his breath, heartbeat, balance and muscle in elderly patients	Not yet recruiting	Intervention	2016-08-01	<NULL>	<NULL>	945	Use of hippotherapy as a tool in the improvement of blood oxygenation, heart rate variability, balance and muscle activation frequency in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-2kw6p9	<NULL>	Medical referral; signing the liability waiver for the practice of hippotherapy; healthy volunteers without acute diseases, both genders, aged 60 years.	Uncontrolled epilepsy; acute diseases; uncontrollable fear or self-destructive behavior; instability of the spine; severe cervical spine conditions like herniated disc; dislocations of the shoulder or hip; evolving scoliosis 30 degrees or more; hydrocephalus valve; arthritic processes in acute phase; decubitus ulcers in the pelvic region or lower limbs and other diseases that can compromise data analysis; and that is not performing any physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-3qx5gd	Organic responses to a videogame session in subjects affected by stroke	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	946	Acute Physiological Responses to Virtual Reality Games in Adults Affected by Stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-11	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3qx5gd	<NULL>	Both genders, aged over 30 years, having suffered a single stroke  in more than 6 months ago.	Obesity greater than grade II; presence of cognitive deficit; presence of cardiovascular disease that precludes exercises; inability to walk on a treadmill.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6brs8b	Study of the visual field of patients treated with the intraocular medication ranibizumab on the disease retinal vein occlusion of the retina.	Not yet recruiting	Intervention	2016-08-03	<NULL>	<NULL>	947	Perimetrical Findings in the double frequency perimetry (PDT) in the treatment of branch vein with Lucentis (Ranibizumab)	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6brs8b	<NULL>	Patients with Branck Retinal Venous occlusion (BRVO) with acute edema that started between 0 and 6 months; visual acuity between 20/40 and  20/400; Central foveal thickness greater than 250 microns , measured in optical coherence tomography (OCT); Age of 18 years or more; Subjects who agreed and signed an informed consent form.	Concomitant Conditions in the study eye that can, in the opinion of investigator, hinder the improvement of visual acuity with the proposed treatment; Opacities of ocular environment; Active intraocular inflammation (inflammation trace degree or above) in any eye; Any active infection (eg conjunctivitis, keratitis, scleritis, uveitis, endophthalmitis.) In either eye; Previous history of uveitis in either eye; Structural damage in the macula in one of the macula center diameter disc in the study eye, which can prevent improvement in visual acuity after resolution of macular edema, including atrophy of the retinal pigment epithelium, subretinal fibrosis, scar (s) by laser or hard exudates arranged in the plate; Eye diseases in the study eye that can confuse the interpretation of the study results, compromising visual acuity or require medical or surgical intervention during the period of 6 months of the study, including retinal detachment, macular hole or choroidal neovascularization of any cause (eg macular disease related to age, ocular histoplasmosis or pathological myopia.); Glaucoma not controlled in the study eye (according to the investigator&apos;s judgment); Retinal neovascularization in the eye of the study;  Previous episode of retinal vein occlusion in the study eye;  afferent pupillary defect.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-67d69p	Treatment of Varicose Veins by Injection of Foam guided by Ultrasound	Recruitment completed	Intervention	2016-08-03	<NULL>	<NULL>	948	Treatment of Varicose Veins by Foam Sclerotherapy Ultrasound-guided	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Hospital Universitário da Universidade Federal de Sergipe	Hospital Universitário da Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-67d69p	<NULL>	Aged between 18 and 60 years inclusive. Male and female sex. Informed consent authorization. Reflux diagnosed by Doppler ultrasound in any saphenous vein extension and / or trunk varicose veins measuring between 4 and 8mm in diameter inclusive. Varicose veins classified APEC 3,4,5 and 6. Body mass index (BMI) between 25 and 40kg/m2.	Patient with psychiatric disorder or limitation in the technique compreendimento. Women during pregnancy or risk pregnancy (without effective contraception) or nursing. Patients with a personal history of deep vein thrombosis and / or PET. Patients with known allergy to Polidocanol (synonyms: Lauromacrogol 400, macrogollauryleter, PEG9lauryl-alcohol). Patients with severe or chronic decompensated (hepatic insufficiency, renal insufficiency, CHF, COPD, respiratory insufficiency, progressive, malignant disease, hypertension and / or diabetes mellitus uncompensated). Intra-atrial or ventricular septal defect diagnosed by echocardiography. Closing of / attend the scheduled follow-ups. Patients who have Peripheral Arterial Disease Installed (ankle-brachial index less than 0, 9)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-9fpjh9	Nutritional Guidance Impact about Food Preservatives in Exams of Hemodialysis Patients	Recruiting	Intervention	2016-08-03	<NULL>	<NULL>	949	Nutritional Guidance Impact with Additives Food Restriction on Phosphatemia in Hemodialysis Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-08	Faculdade de Medicina de Botucatu - UNESP	Hospital das Clínicas de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9fpjh9	<NULL>	Patients aged over 18 years. Patients with chronic kidney disease treated by regular hemodialysis for at least 90 days. Phosphorus serum concentration above 5.5 mg/dL in the month prior to randomization as guidelines K-DOQI.	Impossibility of feeding orally in the last three months. Clinical complications that change the patient&apos;s appetite for more than a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6hhxzv	Laparoscopic uterine removal: comparison between three abdominal incisions&apos; technique or  single umbilical incision surgery	Recruitment completed	Intervention	2016-08-08	<NULL>	<NULL>	950	Laparoscopic Hysterectomy: comparative study between Multiport and Single Port Laparoscopy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-30	Faculdade de Medicina da USP	Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-6hhxzv	<NULL>	age between 35 and 65 years old; benign uterine disease with indication of hysterectomy; no reproductive interest; uterine volume until 600cm3	coagulopathy; chronic use of anti-inflammatory drugs; suspicion of uterine malignancy; contra-indication of general anesthesia or pneumoperitonio; genital prolapse; incapacity of read or understand the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7fpyrp	Assessment of sexual function in low-risk pregnant women	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	951	Evaluation of muscle strength and maternal and perinatal effects of pelvic floor strengthening exercises during pregnancy - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-7fpyrp	<NULL>	Low-risk pregnant women; aged between 18 and 40; literate; capable of getting the MAP checked by vaginal palpation; sexually active (penetrative sex) in the past four weeks, absence of diseases that contraindicate or limit adherence to physical exercise.	Volunteers who have developed diseases that limited exercise;  intolerance physical examination; allergy to condom used in the examination; contraindications of maintaining sexual activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-5h8853	Clinical and Radiographic Evaluations of Restorations in Dentin Surface of Molars Deciduous	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	952	Clinical and Radiographic Evaluation of Minimally Invasive Procedures in Superficial Dentin of Primary Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-10	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h8853	<NULL>	4 to 9 years of age; with at least one carious lesion involving only the occlusal surfaces of primary molars upper or lower; active lesion; cavitation of at most 2 millimeters (mm) in diameter; radiographically limited if the outer half of dentin;	systemic disease; under 4 years or more than 9; inactive caries lesion; caries lesion involving other surface beyond the occlusal; lesions in the inner half of dentin;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6vfg7r	Comparative effectiveness of two catheter locking solutions to reduce catheter-related bloodstream infection in hemodialysis patients.	Recruitment completed	Intervention	2016-08-11	<NULL>	<NULL>	953	Comparative effectiveness of catheter locking solutions with gentamicin/cefazolin versus taurolidine to reduce catheter-related  infection in hemodialysis patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Medicina de Botucatu- Unesp	Hospital Estadual de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-6vfg7r	<NULL>	Incident and prevalent patients on hemodialysis; folowed in the dialysis units of Botucatu Clinics Hospital and the Bauru State Hospital; using incident tunneled central venous catheter for hemodialysis	Patients Under 18; pregnant Women; with other types of dialysis access; with tunneled catheters implanted before November 2014; followed for less than six months after implantation of the catheter; with infection at the time of start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7994vz	Comparison of presence of microorganisms and measurement of calcium , phosphorus . magnesium, sodium and potassium fresh samples collected from the patient side, at home and after pasteurization	Data analysis completed	Observational	2016-08-11	<NULL>	<NULL>	954	Comparison of microbiological and physicochemical property of raw human milk collected at the bedside , at home and after pasteurization	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7994vz	<NULL>	Mothers of newborn preterm who agreed to participate. No consent was obtained for the use of samples taken from the milk bank , as the same were donated by mothers to the hospital	"Mothers who agreed to sign the free and informed consent .
mothers who had their children over 37 weeks of gestation were excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-4kf8zv	Benefit of physical therapy, yoga and music therapy for patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-08-11	<NULL>	<NULL>	955	Effects of physiotherapy associated with yoga and music therapy in Parkinson´s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4kf8zv	<NULL>	Individuals of both sexes; aged 40 to 70 years; diagnosed with Parkinson&apos;s disease; stage 1-3 Hoehn-Yard; able to walk independently; not be modified in drug treatment during participation in the study.	Other neurological disorders as heart disease and / or severe cognitive impairment that could affect the understanding and / or to indicate the completion of the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-3z77p9	The effect of manual therapy in the column on the autonomic nervous system in patients with muscle and joint pain	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	956	The effect of manipulative therapy on cardiac autonomic nervous system of musculoskeletal pain patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-10	Centro Universitário Augusto Motta	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-3z77p9	<NULL>	Pacients in the physiotherapy sector at the Gaffrée and Guinle University Hospital that are experiencing musculoskeletal pain.	"Surgery on the thorax/spine location do not allow realizing the proposal technics; Pregnant women;
Rheumatologic diseases in acute inflammatory phase;Osteoporosis; Bone tumors; Pacemaker carrier; presenting cardiac arrhythmia or being transplanted heart; ingested foods and drinks which containing caffeine on the day of the experiment; consumed alcoholic drinks on the last 24 hours;
Illiterate or unable to fill the self-applied questionnaires."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-5cc79w	Effect of physical exercise on strength, muscle mass,  movement, functional capacity and inflammation in sarcopenic and non sarcopenic elderly	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	957	Effect of resistance training in muscle strength, muscle mass, mobility, functional capacity and biochemicals parameters in sarcopenic and non sarcopenic elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5cc79w	<NULL>	Individuals must be aged 60 or over; both genders; be clinically stable.	Inability to get around; being bedridden; musculoskeletal dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-99qw5h	Effects of body electrical stimulation after the stomach reduction surgery	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	958	Functional, clinical and systemic effects of the body electrical stimulation on bariatric surgery postoperative	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-99qw5h	<NULL>	This research will include obese (BMI 35 kg / m2) or morbidly obese (BMI 40 kg / m2) for at least three years or more without positive results to conventional treatments (pharmacological or not) aged 20 to 45 years will undergo surgery of Gastric Bypass (CBG). Patients with BMI&gt; 30 kg / m2 may also be included according to medical team decision regarding the presence of important comorbidities indicated by Brazilian Bariatric Consensus.	Exclusion criteria are volunteers with orthopedic or neurological impairments that unable participation in an exercise program; myocardial infarction (within the beginning of the six-month study period); implanted pacemaker or any metallic synthesis; unstable angina; chronic disorders of the heart rhythm; moderate or severe valvular heart disease; consistent story of heart disease; uncontrolled hypertension; uncontrolled diabetes mellitus and / or insulin-dependent; beta-blocker users; postmenopausal women and participation in a regular program of physical activity at baseline. It will be also excluded from the present study any COPD volunteers or patients presenting other respiratory diseases or who present any contraindication to cardiopulmonary exercise test or condition that may limit the performance of the functional tests; distal artery diseases; inflammatory diseases; kidney diseases; and liver diseases with documented diabetic neuropathy; cognitive impairment; difficulty in understanding and / or adherence to study procedures; reported using illicit drugs and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-9r347d	Preoperative Testing: a New Protocol	Recruitment completed	Intervention	2016-08-15	<NULL>	<NULL>	959	Impact of Implementation of Preoperative Test Ordering Protocol at University Hospital Gaffrée and Guinle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-30	Hospital Universitário Gaffree e Guinle/ Universidade federal do Estado do Rio de Janeiro	Hospital Universitário Gaffree e Guinle/ Universidade federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9r347d	<NULL>	Patients scheduled to undergoing elective surgery at Hospital Universitário Gaffree e Guinle. Both genders. Older than 18 years. Preoperative assessment performed at Preoperative outpatient clinic of Hospital Universitário Gaffree e Guinle.	patients under 18 years. Emergency surgery. ASA physical status IV or V. Preoperative assessment performed in a different hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-8m7hy7	Effect of Aquatic and Conventional Physiotherapy in Lumbar Spinal Stenosis patients	Recruitment completed	Intervention	2016-08-15	<NULL>	<NULL>	960	Effect of Aquatic and Conventional Physiotherapy on gait, pain, clinical and functional aspects in Lumbar Spinal Stenosis patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-15	Federal University of Rio Grande do Sul	Escola de Educação Física, Fisioterapia e Dança  - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-8m7hy7	<NULL>	Patients of both genders, aging between 30 and 80 years old; diagnosed with Lumbar Spinal Stenosis, confirmed by recent imaging exam;	Patients should not present hystory of spinal or hip cirgury,  tumors or spinal infections, uncontrolled hipertension, urinary incontinence, hidrofobia, oppen wounds or fungic infections; They have to have the ability to make and participated all test; Will be excluded participants that had more than two consecutive absences, three alternate absences, or more that a total of 40 minutos late during intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6hxhx7	Clinical research of pain during restorative treatment in adults using a topical anesthetic photoactivated	Recruitment completed	Intervention	2016-08-15	<NULL>	<NULL>	961	Clinical investigation of intraoperative pain in adults undergoing restorative treatment of non-carious lesions using a topical anesthetic photoactivated	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6hxhx7	<NULL>	Patients over 18 years; with good general and oral health; the premolar teeth should have restorative treatment indication not carious cervical; these non-carious lesions should involve two teeth in different quadrants.	Endodontically treated teeth; destroyed and caries; also excluded are patients with gingivitis; periodontitis and dental mobility; in addition, patients with a history of allergy; any form of sensitivity or allergic reaction to anesthetics and ester-based components of the formula; patients with severe uncontrolled systemic disease (heart problems; neurological; kidney; liver or blood); pregnant or lactating patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6dytyf	Clinical research of pain during treatment sealants in children using a new topical anesthetic photoactivated	Recruitment completed	Intervention	2016-08-16	<NULL>	<NULL>	962	Clinical evaluation of intraoperative pain in children undergoing preventive treatment using a new topical anesthetic photoactivated	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6dytyf	<NULL>	Children 8 to 12 years with good general and oral health; the teeth 36 and 46 should be fully erupted and have sealant indication.	Teeth that are unerupted or carious lesions that require restoration; also a history of allergy patients are excluded; any form of sensitivity or allergic reaction to anesthetics and ester-based components of the formula; severe systemic disease patients not controlled as heart problems; neurological; kidney; liver or blood and even patients not employees.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-4pk67h	Somatic experience as a new technology for the treatment of posttraumatic stress trauma.	Data analysis completed	Intervention	2016-08-16	<NULL>	<NULL>	963	Somatic Experiencing®: Proposing a new technology for the treatment of Stress Disorder Posttraumatic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Hospital Universitário Lauro Wanderley/UFPB	Grupo de Pesquisa Caleidoscópio da Educação/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-4pk67h	<NULL>	They were accepted federal public servants with links and residence in the city of João Pessoa-PB. With a diagnosis of post-traumatic stress acquired in the workplace. Both genders, ages 18 to 70; referred by psychologists and physicians Subsystem Integrated Server-SIASS Health, who freely agreed to participate in all stages of the study. After informed about the objectives, purposes and study of the amounts accepted they signed the informed consent and informed.	Subjects were excluded if they have 10% lack of SE® sessions at any stage of interventions, had severe psychiatric illness, physical condition that did not allow feel bodily sensations, such as numbness, quadriplegia, hemiplegia; not agreed to participate in the research and / or were not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7yrr3s	Effectiveness of desensitizing in reducing tooth sensitivity	Recruitment completed	Intervention	2016-08-16	<NULL>	<NULL>	964	"Clinical evaluation of exposure to derivatives glue and sensitivity after whitening
Dental vital teeth"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-14	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7yrr3s	<NULL>	healthy volunteers; aged 18-40 years anterior teeth with upper and lower vitality; free of decay and restorations on the labial face without cervical lesions; absence of periodontal disease; non-smoking. initial color of at least one tooth is A2 or darker.	Volunteers who have made tooth whitening; using desensitizing folders or product that prevents sensitivity; pregnant women; nursing mothers; presenting teeth staining; endodontic treatment; dental sensitivity; Bruxist; use of medications such as analgesics and anti-inflammatories; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6fs48y	Occurrence and treatment of oral mucositis in subjects in the treatment of head and neck cancer	Recruiting	Intervention	2016-08-16	<NULL>	<NULL>	965	Polihexanide the effectiveness of evaluation in the treatment of oral mucositis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-10	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-6fs48y	<NULL>	Will be allocated to study cancer patients treated with any chemotherapeutic agent and / or radiotherapy in cervicofacial fields; aged over 18; treated in UNACON; who didn&apos;t have treatment for mucositis previously; that having read, understood and signed the Free and Clarified Consent Term (FCCT); and present oral mucositis or injury as a result of cancer treatment.	They will be excluded from the study: patients who refuse to participate in the study; under 18; already in treatment of mucositis; with an allergy to some component of the substances being applied in the study; who refuse to perform subsequent oral assessments; to discontinue the antineoplastic treatment for a period equal to or greater than 8 days; to suspend the use of the substances analyzed in the study; who are hospitalized terminally ill cancer; preventing the oral evaluations, and patients who come to death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-78rd57	Evaluating the use of peripherally inserted central catheter exclusively for parenteral nutrition	Recruiting	Intervention	2016-08-16	<NULL>	<NULL>	966	Evaluating the use of peripherally inserted central catheter exclusively for parenteral nutrition - randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	União Brasileira de Educação e Assistencia	Hospital Universitário de Santa Maria - HUSM	https://ensaiosclinicos.gov.br/rg/RBR-78rd57	<NULL>	All newborn UTINeo that the intern with prescription parenteral nutrition NP and indicating insertion of a peripherally inserted central catheter PICC for this purpose.	"RN diagnosed with clinical or laboratory sepsis according to the criteria of ANVISA 2010;
PICC RN in which the location is not in focus; 
Newborns with umbilical catheter; 
Check-list of PICC insertion procedure with scores below 10; 
Failure to obtain the consent of parents or guardians to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-25xyqp	The use of transcranial electrical current stimulation and physical therapy exercise for rehabilitation of patients after stroke	Recruitment completed	Intervention	2016-08-17	<NULL>	<NULL>	967	The use of transcranial direct current stimulation and therapeutic exercise for rehabilitation of individuals after stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-03	Sociedade Unificada de Ensino Augusto Motta	Sociedade Unificada de Ensino Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-25xyqp	<NULL>	Medical diagnosis of strok; age between 30 and 80 years;hemiparesis; asymmetry in weight shift; must be able to cooperate with training; independent gait with or without auxiliary equipment running; standing for 5 minutes without support and without bracing.	Over 10 years post stroke; cognitive impairment; other neurologic disorders; orthopedic problems; hypertension or decompensated arrhythmia; neglect or apraxia; severe visual impairment uncorrected; dizziness; presence of metal implant; headache constant and no diagnosis; history of seizures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7b5hhk	Effects of pumpkin (Cucurbita ficifolia Bouché) in lipid and glycemic profile of type 2 diabetics individuals: a randomized double blinded clinical trial	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	968	In vivo evaluation and monitoring with nanosensors effect hypoglycemic of cucurbita ficifolia Bouché in type 2 diabetic patients	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2012-11-05	Embrapa Hortaliças	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7b5hhk	<NULL>	Individuals diagnosed with pre-diabetes (&gt; 100 to &lt; 125 mg/dL) and individuals diagnosed with type 2 diabetes mellitus (&gt; 126 to &lt; 300 mg/dL).	Individuals diagnosed with Type 2 diabetes for over 6 months with blood glucose &gt; 300 mg/dL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-3wwqc3	Investigation of clinical pain during sealing treatment using topical anesthesia.	Recruitment completed	Intervention	2016-08-23	<NULL>	<NULL>	969	Clinical evaluation of intraoperative sensitivity in children undergoing preventive treatment using topical anesthesia with new anesthetic gel.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3wwqc3	<NULL>	Children 8 to 12 years with good general and oral health; the teeth 36 and 46 should be fully erupted and have sealant indication.	Teeth are not fully erupted or carious lesions that require restoration; also a history of allergy patients are excluded; any form of sensitivity or allergic reaction to anesthetics amide base; severe systemic disease patients not controlled as heart problems; neurological; kidney; liver or blood and even patients not employees.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-2dbzdy	Early Neuromuscular Electrical Stimulation in Critically Ill Trauma Patients	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	970	Neuromuscular electrical stimulation in patients with Traumatic Brain Injury under prolonged mechanical ventilation: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Hospital de Base do DF	https://ensaiosclinicos.gov.br/rg/RBR-2dbzdy	<NULL>	Major trauma patients were assessed for eligibility within the first 24 hours after hospital admission. Adults older than 18 years old with invasive mechanical ventilation were included.	pregnancy; stroke; previous neuromuscular disease; suspicion of brain death; lower limb amputation, fracture or skin lesion that restrained ultrasound evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-38zssz	Daylight photodynamic therapy application in the treatment of a superficial skin carcinoma	Recruiting	Intervention	2016-08-24	<NULL>	<NULL>	971	Daylight photodynamic therapy application in the treatment of Bowen&apos;s disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-38zssz	<NULL>	Patients with clinical and histological diagnosis of Bowen´s disease at the Department of Dermatology of the Hospital de Clínicas de Porto Alegre.	Patients with allergy to medications under treatment; porphyria; pregnancy; lactation; lesions in area of difficult sun exposure; lesions with clinically-suggested invasive carcinoma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-8qqzk8	Avaliation of efficacy of Trial-Based Cognitive Therapy in the adherence to drug treatment in HIV-infected patients	Recruitment completed	Intervention	2016-08-24	<NULL>	<NULL>	972	Controlled trial comparing the efficacy of Trial-Based Cognitive Therapy (TBCT) and standard treatment about the adherence to the treatment of patients with HIV/AIDS  with antiretroviral therapy failure assisted in Salvador, Bahia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-16	Fundação Bahiana de Infectologia	Universidade Federal de Bahia	https://ensaiosclinicos.gov.br/rg/RBR-8qqzk8	<NULL>	HIV-infected patients with viral load higher than 500 copies/mL in the last two tests or virologic controlled due to non-adherence to antiretroviral therapy. Age between 18 and 65 years, to be able to write and follow the protocol&apos;s instructions and sign informed consent.	Difficult with reading and whitting activities; the patient can not participate in another psychological therapy, and he can not have psychiatric or clinical diagnosis that interferes in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3phy2q	ketorolac antiinflammatory effect associated with a combination of analgesic tramadol/acetaminophen after third molars surgery	Recruiting	Intervention	2016-08-24	<NULL>	<NULL>	973	Analgesic effectiveness of oral ketorolac associated with a combination of analgesics tramadol/acetaminophen after impacted third molars surgery: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3phy2q	<NULL>	&quot;Volunteers of both genders; aged 18 to 35 who have  indication of third molar elective extraction and look for treatment at the clinic of Dentistry; State University of Ponta Grossa. Each patient should have two impacted third molars in a similar position; symmetrical bilaterally; according to Pell  and Gregory and Miller Winter rating; and at least 1/3 of the formed root; according to radiographic evaluation; classified as class I or II, B and C Pell and Gregory. Patients must be healthy; without systemic changes and classified as ASA I; American Society of Anesthesiologist&quot;.	&quot;Patients with a history of hypersensitivity to ketorolac; pregnancy;  asthmatics; diabetics; lactation; hypertensive; patients with gastrointestinal disorders; myasthenia gravis or glaucoma are not included in the study. Immunosuppressed patients; dependent on narcotic drugs; patients with neurological and or behavioral changes; inflammatory users or antihypertensives continuously will also be excluded from the sample&quot;.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-6j3x5q	Clinical evaluation of restorations carried out on newly whitened teeth	Not yet recruiting	Intervention	2016-08-25	<NULL>	<NULL>	974	Clinical evaluation of an antioxidant on bond strength of esthetic restorations in newly whitened teeth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-05	Universidade Estadual de Maringá	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6j3x5q	<NULL>	Volunteers with canines and upper and lower premolars with non-carious lesions of abfraction, abrasion and erosion featuring color change A3 or higher by Vitapan scale; presenting at least 4 teeth on the sample, so that each tooth represents one of the groups; have at least 20 teeth in function and lesions that contain at least fifty percent of enamel margins.	Canines and bicuspids with endodontic treatment; who do not have the need to be restored; which suffered action of bleaching agents previously; with periodontal disorders; with active caries; with changes in the formation of enamel.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-2dyf33	Fluoride varnish to prevent dental caries in primary teeth	Not yet recruiting	Intervention	2016-08-29	<NULL>	<NULL>	975	Effectiveness of fluoride varnish to prevent dental caries in primary teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Faculdade de Odontologia da Universidade do Oeste Paulista	Faculdade de Odontologia da Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2dyf33	<NULL>	"Children will be included from 1 to 4 years;
Which are classified in the A + risk B - / +, C - / +, D - / + and - / +, F - / + G - / +;
Which reside in the city of Presidente Prudente for at least one year;
Plan to live in the city for the next two years;
Who attend public schools;
And have the consent of parents or guardians."	"Children will be excluded classified A- risk;
Children who received professional application of fluoride in the last six months;
Which have more than ten carious lesions;
And are suffering from systemic disease that may aggravate oral problems or interfere with search results"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-52fq9q	Effect of the strategies of an orientation program of lifestyle and healing in patients with venous ulcers	Recruiting	Intervention	2016-08-31	<NULL>	<NULL>	976	Effect of the strategies of an orientation program of lifestyle and the process of healing in patients with venous ulcers: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-52fq9q	<NULL>	Characteristics of venous ulcer: clinical signs observed;Index ABI&gt; 0.8 and &lt;1.3; Over age 18; Venous Ulcer with a minimum of six weeks and &gt;0,2cm2 size; Treatment with inelastic compression therapy.	"Medical diagnosis of osteomyelitis;Patients with Diabetes Mellitus;
Patients with infected wounds;pregnant or breastfeeding; Patients with cognitive understanding of disability"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-8rw7dz	Physical exercise and feeding influence over obesity, high pressure, diabetes and high cholesterol in adults and elderly from Santo Antônio de Goiás city.	Data analysis completed	Intervention	2016-09-01	<NULL>	<NULL>	977	Metabolic syndrome: prevalence and effects of physical exercise and nutritional supplementation in adults and elderly of Santo Antônio de Goiás city.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rw7dz	<NULL>	Women, 20 to 60 years old range, phisically inactive, body mass index higher than 25kg/m2, waist circumference higher than 88cm, any morbidity presench such as hypertension, hyperglycemia or dislipidemias.	Presence of orthopedic limitation, neurological or cardiovascular disease that prevent oriented physical moderate exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-4d39z9	Physical training and type 2 diabetes	Recruitment completed	Intervention	2016-09-02	<NULL>	<NULL>	978	Effects of resistance and aerobic training on markers of cellular aging in type 2 diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4d39z9	<NULL>	Aged between 45 and 70 years; both genders; previous diagnosis of type 2 diabetes for a period longer than 1 year, according to the criteria of the American Diabetes Association; treatment with oral hypoglycemic agents only (do not use insulin).	Classified as physically active; history of myocardial infarction within past 6 months or other any unstable chronic condition, including dementia, alcoholism, dialysis, retinal hemorrhage or detachment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-46zk89	Effects of self-care rests on knowledge, self-care and metabolic control in adult men with diabetes mellitus	Recruiting	Intervention	2016-09-05	<NULL>	<NULL>	979	Effectiveness of self-care rests on knowledge, self-care and cardiometabolic control of adult men with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-19	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-46zk89	<NULL>	"Having medical diagnosis of DM2.
Being male.
Age between 40 and 70 years.
Is domiciled in the city of Maringa in the FHS coverage area.
Being part of the ESF families register.
Being able to answer the questions of data collection instruments.
Relate visual ability, hearing and locomotor to perform self-care.
Have telephone contact (mobile or fixed) for monitoring the program."	"Present lesions in target organs (brain, heart, kidneys, eyes) or comorbidities/complications resulting from diabetes, recorded in medical records, such as chronic renal failure.
Have psychological or other disorders, registered in the medical records, and that compromise the understanding of the study, who do not agree or do not have availability to participate in the intervention.
Moving to another location that does not have coverage of the ESF, or even to another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3pfcjs	Short film to promote self-care in people with diabetes and at-risk foot	Recruiting	Intervention	2016-09-05	<NULL>	<NULL>	980	Construction and validation educational video to promote people with diabetes and foot self-care at risk	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-20	Universidade Estadual do Ceará-UECE	Coordenadoria de Gestão do  Trabalho e Educação na Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3pfcjs	<NULL>	people with type 2 diabetes aged 40 years and older, of both sexes; with diagnosed type 2 diabetes for at least two years; registered; monitored regularly in these Primary Healthcare Units.	disoriented in time and space or presenting some difficulty that prevents them from communicating and answering the instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-5wx47j	Treatment of bile duct stones of difficult removal compared two endoscopic methods: Stone fragmentation with electrohydraulic lithotripsy (EHL) X  balloon dilation of the major duodenal papilla	Recruitment completed	Intervention	2016-09-05	<NULL>	<NULL>	981	Endoscopic treatment of bile duct stones of difficult removal compared two methods: Use of Direct Visualization System of Bile Ducts (&quot;Spyglass Direct Visualization System&quot;) associated with electrohydraulic lithotripsy (EHL) X  hydrostatic balloon dilation of the major duodenal papilla followed by scanning extractor balloon	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5wx47j	<NULL>	Over 18 years and both genders (male and female). Capable of consent, agreed and signed the Term of Consent. Bile duct stones considered difficult to remove. Biliary stones in bile ducts	Age below 18 years. Incapable of giving consent. Pregnant. Gastrointestinal bypass surgery with previous reconstructions as Billroth II or Roux-en-Y. Patients with signs of severe acute cholangitis requiring biliary drainage with fast plastic stent and minimal or no contrast infusion. Patients with previous liver transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-5ndq22	Reflexology feet for lumbar pain relief acute related to work of nursing team: randomized controlled trial	Recruitment completed	Intervention	2016-09-06	<NULL>	<NULL>	982	Reflexotherapy podal for lumbar pain relief acute related to work of nursing: team randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5ndq22	<NULL>	Professional nursing staff of HU; presenting acute low back pain nursing professional active in hospital environment; present feet free of injury or healthy;age between 18 and 80 years	Subjected to parallel treatment for relief of low back pain or complementary therapy; participation and some other research for tatramento of pain; present vascular disorders in lower limbs, varicose ulcers or thrombosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-58ghgp	Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer	Recruiting	Intervention	2016-09-06	<NULL>	<NULL>	983	"EGF117165 - A phase II, open-label study to evaluate biomarkers
associated with response to subsequent therapies in subjects
with HER2-positive metastatic breast cancer receiving
treatment with Trastuzumab in combination with Lapatinib or
Chemotherapy"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2016-01-04	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-58ghgp	<NULL>	Female equal or more than 18 years; histologically or cytologially confirmed invasive breast cancer with distant metastasis; subjects must have at least one measurable lesion per RECIST 1.1 (Note: biopsied lesions should not be used as target lesions.); HER2 overexpression or gene amplification, in the invasive component of either the primary tumor or metastatic disease site as defined as: 3+ by Immunohistochemistry (IHC) and/or centrally determined HER2-positive, hormone receptor status, breast molecular subtype by prediction analysis of microarray 50 (PAM50) on the pre-treatment biopsy of metastatic lesion obtained during screening (Note: biopsied lesions should not be used as target lesions.); progression on at least 2 lines of anti-HER2-targeted therapies for metastatic breast cancer (MBC); documented radiological disease progression during the most recent treatment regimen for metastatic disease; most recent treatment regimen for metastatic disease must include Trastuzumab and chemotherapy (Note: Trastuzumab emtansine (T-DM1) is considered acceptable as prior Trastuzumab/chemotherapy regimen); agreement to provide 2 tumor biopsies; prior treatment with pertuzumab, Lapatinib, and/or Trastuzumab emtansine is allowed. However, the last treatment for MBC must not include Trastuzumab in combination with pertuzumab; subjects with radiographically stable central nervous system (CNS) metastases, defined as radiographically stable on the previous 2 brain imaging scans, asymptomatic, and off systemic steroids and anticonvulsants for at least 1 month are eligible; treatment with prophylactic anticonvulsants is permitted unless listed under prohibited medications; discontinuation of all prior chemotherapy, immunotherapy, or biological therapy at least 3 weeks prior to the first dose of investigational product is required (Note: discontinuation of Trastuzumab is not necessary); all treatment related toxicities, except alopecia, must have recovered to grade 1 or better (common terminology criteria for adverse events (CTCAE) version 4.0) prior to administration of the first dose of study treatment; baseline left ventricular ejection fraction (LVEF) equal or more than 50% as measured by echocardiogram (ECHO) or Multigated acquisition (MUGA) and above the testing institution&apos;s lower limit of normal; QT interval corrected (QTc) less than 450 millisecond (msec) or QTc less than 480 msec for patients with bundle branch block; women childbearing potential must have a negative serum pregnancy test within 7 days prior to the first dose of study treatment and agree to use effective contraception, during the study and for 30 days following the last dose of study treatment; Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; completion of screening and baseline assessments; able to swallow and retain orally administered medication and does not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels; at least 4 weeks must have elapsed since the last surgery and 2 weeks must have elapsed since radiotherapy; adequate baseline organ function as defined hereafter: absolute neutrophil count equal or more than 1.5 x 10^9/litre (L); hemoglobin equal or more than 9.0 grams/decilitre(g/dL) (after transfusion if needed); platelets equal or more than 100 x 10^9/L; albumin equal or more than 2.5 g/dL; serum bilirubin less than or equal a 1.25 x upper limit of normal (ULN)(these values must be independent of growth factor support and stable for at least one week post transfusion); alanine aminotransferase and aspartate aminotransferase (AST and ALT) less than or equal a 2.5 x ULN; calculate creatinine clearance more than or equal a 40 mL/min (with the exception of those subjects who have Gilbert&apos;s syndrome, the bilirubin in these subjects should be at their baseline).	Lactating female (Note: women with potential to have children must be willing to practice acceptable methods of birth control during the study); bone-only disease and/or disease that cannot be biopsied; unstable CNS metastases or leptomeningeal carcinomatosis not considered radiographically stable (Note: subjects with radiographically stable CNS metastases are defined as radiographically stable on the previous 2 brain imaging studies, asymptomatic, and off systemic steroids and anticonvulsants for at least 1 month; treatment with prophylactic anticonvulsants is permitted unless listed under prohibited medications); any serious and/or unstable pre-existing medical, psychiatric disorder, or other conditions including concurrent disease that could interfere with subject&apos;s safety, obtaining informed consent, or compliance with the study procedures; serious cardiac illness or medical condition including but not confined to: uncontrolled arrhythmias (e.g. ventricular tachycardia, high-grade atrioventricular (AV)-block, supraventricular arrhythmias which are not adequately rate-controlled); angina pectoris requiring antianginal medication; history of congestive heart failure or systolic dysfunction (LVEF &lt;50%); documented myocardial infarction &lt;6 months from study entry; evidence of transmural infarction on ECG; poorly controlled hypertension (e.g. systolic &gt;160milimiter (mm) mercury (Hg) or diastolic &gt;100mm Hg); clinically significant valvular heart disease; current active hepatic or biliary disease (with exception of subjects with Gilbert&apos;s syndrome, asymptomatic gallstones, liver metastases, or stable chronic liver disease per investigator assessment); any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels as well as subjects with ulcerative colitis are also excluded; any prohibited medication; prior treatment with Trastuzumab in combination with Lapatinib or prior treatment with an irreversible inhibitor of the intracellular domain of the HER2 receptor such as neratinib; last treatment for metastatic disease including Trastuzumab in combination with pertuzumab; administration of an investigational drug within 30 days or 5 half-lives, whichever is longer, preceding the first dose of study treatment; a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to any of the study drugs or their excipients that, in the opinion of the investigator or GSK medical monitor, contraindicates participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-8cxzf2	Parkinson&apos;s disease: effects of Aquatic Exercise Dual Task in balance and functionality	Recruitment completed	Intervention	2016-09-06	<NULL>	<NULL>	984	Analysis of the effects of an Aquatic Exercise Program on functional activities and upright posture of subjects with Parkinson&apos;s Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Paraná	Pontifícia Universidade Católica - PUCPR	https://ensaiosclinicos.gov.br/rg/RBR-8cxzf2	<NULL>	Both sexes; Clinical diagnosis of idiopathic Parkinson&apos;s disease; Stages 1 to 4 in the Hoehn and Yahr; Clinical Attestation for aquatic exercise and to attend the heated pool.	- Not having independent gait related or unrelated to the DP; Another condition that can interfere with physical assessments and QOL and make it impossible to participate in the research; Cognitive impairment that precludes follow verbal instructions; Visual or auditory sensory deficit that prevents follow verbal and visual instructions; Contraindications to attend heated pool, such as fever, urinary or fecal incontinence, blood pressure change, open wound; Do not agree to the IC; Present change in drug prescription during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-2n9nhj	A school-based intervention to improve sense of coherence and children&apos;s oral health related quality of life	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	985	A school-based intervention to improve sense of coherence and children&apos;s oral health related quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-2n9nhj	<NULL>	Children enrolled in the fourth and fifth years in the selected schools.	Children intellectually and physically uncapable of responding to the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-62jk22	Effects of physical exercise and nutrition on the risk of heart disease in adults and elderly in city San Antonio of Goiás	Data analysis completed	Intervention	2016-09-08	<NULL>	<NULL>	986	Metabolic syndrome: prevalence and effects of physical exercise and nutritional supplementation in adults and elderly of city Santo Antonio Goiás	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal de Goiás	Paulo Adriano Naves Prudente	https://ensaiosclinicos.gov.br/rg/RBR-62jk22	<NULL>	Women; age 18-59 years; not be taking regular exercise and targeted to at least one year; have the permission of the medical team for physical exercise; availability time in three days a week in the evening for an hour a day for 6 months; no orthopedic limitations; absence of neurological limitations; absence of severe cardiovascular disease that would prevent the practice of physical exercises.	Unavailability time; history of abuse of alcohol or drugs; We are practicing physical exercise regularly over the past 12 months; not have medical clearance for physical exercise; physical limitations that prevent physical exercise; neurological limitation that prevents physical exercise; cardiovascular disease in serious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-5dnmsk	Association of compounds as an alternative for the treatment of tooht with hypersensitivity	Recruiting	Intervention	2016-09-08	<NULL>	<NULL>	987	Association of monomers as an alternative for the treatment of dentin hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal de Santa Maria- UFSM	Universidade Federal de Santa Maria- UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5dnmsk	<NULL>	Individuals healthy ; both genders; aged between 18 and 80 years; with clinical symptoms dentin hypersensitivity two permanent; teeth in different quadrants; with exposed cemento-enamel junction; without cavitation at the clinical examination	Tooht with carious lesions; defective restorations; erosion; post-operative sensitivity after periodontal treatment or bleaching; bruxism; pulpitis; root fracture; or other conditions that may cause or predispose to the development of dentin hypersensitivity; individuals with special; needs or cognitive impairment compromising data collection; minors (&lt;18y); pregnants; individuals undergoing treatment for dentin hypersensitivity in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-2shfhj	Effect of creatine associated with a resistance training on muscle mass, strength and physical fitness in elderly with loss of muscle mass	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	988	Effect of creatine supplementation associated with a resistance training program on muscle mass, strength and physical performance in sarcopenic elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-04	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2shfhj	<NULL>	Between 60 and 80 years of age.	Vegetarian; Have taken any ergogenic aid in the last six months prior to study initiation; ingest any medication that is able to affect muscle growth or the ability to train intensely during the study, such as statins, muscle relaxants, anti-inflammatory; be involved in restricting food programs; be involved in physical training programs; have received contrast or performed radioactive procedure during the last year; is diagnosed with any kidney, liver and heart diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-98qjbw	Effects of different cognitive behavioral therapies to social anxiety disorder using different measures	Recruitment completed	Intervention	2016-09-08	<NULL>	<NULL>	989	Effects of different cognitive behavioral therapies to social anxiety on memory, attention and galvanic skin response	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto - Universidade de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-98qjbw	<NULL>	There are different inclusion criterias for participants with social anxiety disorder and healthy individuals. Inclusion criteria for participants with social anxiety disorder: individuals aging 18 to 45 years old; both gender; with scores equal or higher than 19 points at social phobia inventory; and confirmation of social anxiety disorder as the primary diagnoses. Inclusion criterias for healthy individuals: healthy volunteers aging 18 to 45 years old; both gender; that do not present social anxiety disorder ou any other mental disorder.	Age under 18 and older than 45 years old; psychotic symptoms and accentuated cognitive deficits; and the presence of social anxiety disorder as a secondary diagnoses to other disorders and conditions; individuals in  psychotherapy treatment until the beggining of the interventions and that did not want to interrupt the treatment in progress. Exclusion criterias to comparison healthy group: any psychiatric condition, beside all the exclusion criterias described above.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3t8prz	Pessary (cervical Ring) plus Progesterone to prevent Preterm delivery	Recruiting	Intervention	2016-09-08	<NULL>	<NULL>	990	Pessary plus Progesterone to prevent Preterm delivery in women with short cervical length: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UNIVERSIDADE ESTADUAL DE CAMPINAS	UNIVERSIDADE ESTADUAL DE CAMPINAS	https://ensaiosclinicos.gov.br/rg/RBR-3t8prz	<NULL>	pregnant women between 18 weeks and 0 days and 22 weeks and 6 days of gestation with cervical length lower or equal 30 mm	Placenta previa diagnosed by US second or third quarter; greater than 1 cm cervical dilatation; painful uterine activity; active vaginal bleeding; cervical cerclage in the current pregnancy; cervical length &lt;5 mm; Rupture of Membranes; severe liver disease; cholestasis occurred while current pregnancy;  History or thromboembolic event during the pregnancy; monoamniotic Twin pregnancy; Multiple pregnancies with 3 or more fetuses; ultrasonographic signs of fetal-fetal transfusion; selective growth restriction diagnosis of type 2 or 3 Gratacós; Major fetal anomalies; Fetal death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-36d8nf	Effect of vibration stimulus in fibromyalgia women	Recruitment completed	Intervention	2016-09-09	<NULL>	<NULL>	991	Acute effect of whole body vibration in neuro endocrine inflammatory parameters in fibromyalgia women	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação de Amparo à Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-36d8nf	<NULL>	"Fibromyalgia: present confirmed diagnosis of fibromyalgia by rheumatologist. According to the American College of Rheumatology for the characterization of the disease, the symptoms must persist for at least 3 months.
Control: not present rheumatic disease or serious general health changes and not be inserted in any physical activity program. These women were selected paired form (1:1) according to age and anthropometric variables with fibromyalgia group."	being a smoker; drinking alcohol; make use of immunosuppressive medication; present any concomitant disease that can be exacerbated by physical activity; pregnancy; orthopedic impairments; respiratory and inflammatory diseases or cardiovascular diseases; be followed up with a psychiatrist, or perform physical activity for the same 2 times a week; Acute hernia; thrombosis; epilepsy; orthopedic injuries; prostheses. The above criteria were used for both groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-8nv3fg	Impact of pelvic floor phisiotherapy during pregnancy in urinary incontinence and delivery.	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	992	Relation among pelvic floor phisiotherapy during pregnancy, urinary incontinence and obstetric outcome.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-30	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8nv3fg	<NULL>	Pregnant between 12 and 20 weeks of pregnancy; without previous deliveries.	Diabetes; fetal malformation unfeasible to vaginal delivery; urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-96cy3k	Evaluation of onset time and duration of Rocuronium in differet doses when used with Magnesium Sulfate	Recruitment completed	Intervention	2016-09-09	<NULL>	<NULL>	993	Interference of Magnesium Sulfate in onset time and duration of Rocuronium in different doses	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2014-01-01	Hospital Universitário Cassiano Antônio de Moraes	Hospital Universitário Cassiano Antônio de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-96cy3k	<NULL>	Patients of aged 18 to 65 years;  both gender; ASA physical status I or II; body mass index (BMI) between 18 and 27; with general anesthesia indication under tracheal intubation and controlled mechanical ventilation for elective surgical procedures indicating use of muscle relaxant.	Use drugs that can influence neuromuscular blockade (as phenytoin and aminoglycosides); hepatic, renal ou cardiac impairment; neuromuscular disease; predictability of difficulty in ventilation by mask or intubation; risk or confirmation of pregnancy; patients with inadequate preoperative fasting or at risk of pulmonary aspiration; electrolyte disorders, use magnesium supplementation; other contraindications to the use of parenteral magnesium; surgery associated with massive bleeding or high volume replacements; patients that develop electrolyte or acid-base disturbance, hypothermia or any other intraoperative condition that interferes with neuromuscular blockade	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4h97rb	Low Level Laser Therapy and exercise to patients with chronic pain and rheumatic diseases: randomized clinical trials with pain , quality of life, functionality assessments and biomechanical aspects.	Not yet recruiting	Intervention	2016-09-12	<NULL>	<NULL>	994	Low Level Laser Therapy and exercise to patients with chronic pain and rheumatic diseases: randomized clinical trials with pain , quality of life, functionality assessments and biomechanical aspects.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Universidade de Brasília	Centro Universitário Unieuro	https://ensaiosclinicos.gov.br/rg/RBR-4h97rb	<NULL>	Being older than 18 years; To track across at least one of the clinics, with diagnosis made by the medical staff; Be able to fill out the consent form and clear.	Having the diagnosis of acute pain; severe psychiatric disorder; Diagnosis of chronic infectious disease; acute or chronic underlying disease with a high probability of death soon; exercise performance or other intensive treatment for pain for up to 48 hours of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-9hckj4	Study to evaluate safety and possible adverse reactions, especially serious, with a vaccine for measles and rubella in healthy subjects.	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	995	Phase I trial to evaluate safety and immunogenicity of Measles and Rubella vaccine (MR) for measles and rubella, in young adults	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2015-09-18	Bio-Manguinhos/Fiocruz/MS	Bio-Manguinhos/Fiocruz/MS	https://ensaiosclinicos.gov.br/rg/RBR-9hckj4	<NULL>	Healthy volunteers on screening; male; aged between 18-49 years; availability to provide personal data; availability in strictly follow the research protocol; accept not participate in any other clinical trial during this one and up to 6 months after the end; ability to understand and sign the informed consent term; ability to record symptoms at home; acceptance of HIV testing for HIV, HBV and HCV.	Serious adverse event due to the study vaccination; acute or chronic disease; use of allergy shots with antigens, up to 14 days prior to study vaccination; immunoglobulin use in the last 12 months prior to vaccination; use of blood products in the 12 months prior to vaccination; use of any type of vaccine 30 days before vaccination; Chronic use of any medication, except for homeopathic and trivial; previous use of immunosuppressant or cytotoxic medication; use of any investigational medication 1 year prior to vaccination; asthma (unstable, that has required urgent care in the last 24 months, or requiring the use of corticosteroids); neurological, cardiovascular, respiratory, hepatic, renal, hematologic, rheumatic or autoimmune - clinically significant; coagulopathies; Seizures before age 2 years; psychiatric illness that hinder adherence to the protocol; Active malignancy; asplenia; HIV, HCV and / or HBV positive; alcohol abuse (CAGE criteria); illicit drugs abuse; congenital or acquired immunodeficiency; allergy vaccine components, such as egg, neomycin and gelatin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-84jx98	Assessment of the effects of TENS in patients with low back pain treated with acupuncture.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	996	The assessment of the effects of analgesia in transcutaneous electrical stimulation associated with acupuncture in patients with chronic low back pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-10	Universidade Federal de Pernambuca - UFPE/ Brasil	Universidade Federal de Pernambuca - UFPE/ Brasil	https://ensaiosclinicos.gov.br/rg/RBR-84jx98	<NULL>	Patients aged from 40 years; both sexes; with a history of low back pain for more than three months.	In addition to not meet the inclusion, they will also be considered affected or carriers of any concomitant arthropathy; those who are undergoing cancer treatment; which have chronic diseases or changes in neurological examination as Parkinson&apos;s disease, Alzheimer&apos;s and Stroke rehabilitation. Also excluded are patients who do not accept (or their relatives) sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-5k92hq	The evaluation of the use of Alprazolam in third molar surgery	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	997	The evaluation of the use of Alprazolam in outpatient third molar surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-03	Faculdade de Odontologia da Universidade Federal do Pará	Faculdade de Odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5k92hq	<NULL>	The inclusion criteria comprised ASA I patients(according to American Society of Anesthesiology; both genders; ranging from 18 to 45 years old and who needed bilateral maxillary and mandibular third molars extraction	The exclusion criteria comprised presence of systemic changes (ASA III or IV patients); history of hypersensitivity or allergies to benzodiazepines; recent use of benzodiazepines; pregnancy; dependency on narcotic drugs; narrow-angle glaucoma; alcoholism and patients under chronic use of sedatives or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-83484y	Physical activity and healthy in elderly.	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	998	Resistance and concurrent training with blood flow restriction: hearat rate variability, systemic inflammation effects and neuromuscular adjustments in men and women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-30	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83484y	<NULL>	Volunteers irregularly active or sedentary; both sexes; over 60 years old; non smokers.	Manifestation of ischemic myocardial disease; diabetes; arrhythmias; hypertension; use of medications for the mentioned diseases; joint limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-3kzxsf	A placebo versus study medication trial study for verification of improving survival in metastatic colorectal cancer patients.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	999	A phase III double-bblinded, placebo controlled study of xilonix™ for improving survival in metastatic colorectal cancer.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-29	XBiotech USA Inc	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-3kzxsf	<NULL>	Subjects with pathologically confirmed colorectal carcinoma that is metastatic or unresectable and which is refractory to standard therapy; to be considered refractory, a subject must have experienced progression (or intolerance) after treatment with at least all of the following agents: oxaliplatin, irinotecan, flouropyrimidine, and cetuximab or panitumumab if KRAS (retrovirus-associated DNA (desoxinucleic acid) sequences isolated from Kirsten murine sarcoma viruses) wildtype; subjects will not be treated with any radiation, chemotherapy, or investigational agents while enrolled in this protocol;  Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2; at least 2 weeks since the last previous cancer treatment including: chemotherapy, radiation therapy, immunotherapy, surgery, hormonal therapy, or targeted biologics and 4 weeks for patients who received treatment immediately prior to the study with anti-IL-1 (anti-interleukin 1) or anti-TNF (tumor necrosis factor) agents; age 18 years or older, male or female subjects; serum potassium and magnesium levels within Central Lab normal limits. Total serum calcium or ionized calcium level must be greater than or equal to the lower limit of normal. Subjects with low potassium, calcium and magnesium levels may be replenished to allow for protocol entry; adequate renal function; adequate hepatic function; adequate bone marrow function; for women of childbearing potential (WOCBP), a negative serum pregnancy test result at screening and monthly thereafter; for women who are not postmenopausal (24 months of amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to use adequate methods of contraception, during the treatment period and for at least 1 month after the last dose of study drug; signed and dated institutional review board (IRB)-approved informed consent before any protocol-specific screening procedures are performed; patients enrolled must, in the investigator’s judgment, be healthy enough to stay on the clinical trial for three months.	Mechanical obstruction that would prevent adequate oral nutritional intake; serious uncontrolled medical disorder, or active infection, that would impair the ability of the patient to receive protocol therapy; uncontrolled or significant cardiovascular disease; dementia or altered mental status that would prohibit the understanding or rendering of informed consent; subjects who have not recovered from the adverse effects of prior therapy at the time of enrollment to grade equal or lower than 1, excluding alopecia and grade 2 neuropathy; immunocompromised subjects; history of hepatitis B or C; history of tuberculosis; receipt of a live (attenuated) vaccine within 1 month prior to screening; subjects with history of hypersensitivity to compounds of similar chemical or biologic composition of xilonix; women who are pregnant or breastfeeding; WOCBP or men whose sexual partners are WOCBP who are unwilling or unable to use an acceptable method of contraception for at least 1 month prior to study entry, for the duration of the study, and for at least 1 month after the last dose of study medication; weight loss higher than 20% in the previous 6 months; history of progressive multifocal leukoencephalopathy or other demyelinating disease; subjects on immunosuppressive therapy, including transplant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-884bdg	Mobilize response on joint pain and muscle activity in dysfunction temporomandibular: randomized controlled trial study	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	1000	Cranoicervicomandibular system : evaluation methods and multimodal therapeutic intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-884bdg	<NULL>	Women; have TMD diagnosis as the RDC / TMD instrument; Temporomandibular index greater than 0.5 ; belong to age group 18-40 years; patients able to understand commands ; are willing to participate in the study by signing the free and informed consent.	Fracture or previous surgery in orofacial or cervical region; a neurological disorder or neoplastic disease in the craniocervical region; irritable nerve compression evidence assessed by neural tests for the median, radial and ulnar ; They are making use of medications during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-5skmvw	Effect of mobilization of the temporomandibular joint and hyoid bone in the neck system: controlled randomized clinical trial	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	1001	Craniocervicomandibular system : evaluation methods and multimodal therapeutic intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5skmvw	<NULL>	Women; have TMD diagnosis as the RDC / TMD instrument; Temporomandibular index greater than 0.5 ; belong to age group 18-40 years; patients able to understand commands ; are willing to participate in the study by signing the free and informed consent.	Fracture or previous surgery in orofacial or cervical region; a neurological disorder or neoplastic disease in the craniocervical region; irritable nerve compression evidence assessed by neural tests for the median, radial and ulnar ; They are making use of medications during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-6jg23g	Does desflurane anesthesia associated or not with nitrous oxide induce genotoxicity and oxidative stress in patients?	Recruitment completed	Intervention	2015-04-14	<NULL>	<NULL>	1002	Does desflurane anesthesia associated or not with nitrous oxide induce genotoxicity and oxidative stress in patients?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-29	Departamento de Anestesiologia	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6jg23g	<NULL>	Healthy individuals who do not present other disease unless the operative condition, undergoing elective ENT and ophthalmic surgery, lasting at least 90 minutes	Smoking, using illicit drugs and alcohol, users of daily vitamin supplements and / or antipyretics, analgesics, antibiotics, anti-inflammatory, among others, the occupationally exposed to paints, fuel, pesticides and hospital environments, those who received radiation ionizing or MRI done in less than 30 days, those who have already undergone chemotherapy or radiotherapy, patients with diseases such as asthma, hypertension, diabetes, cancer, infectious or inflammatory processes, and those who are not referred for surgery of ENT and ophthalmology clinic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-9mbdj3	Safety assessment and dose of fibrin sealant derived from snake venom in the treatment of wounds.	Recruitment completed	Intervention	2016-09-13	<NULL>	<NULL>	1003	Clinical trial phase I / II to evaluate the safety and best dose of the new fibrin sealant derived from snake venom in the treatment of venous ulcers - Study SELANTE I.	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2014-03-10	Faculdade de Medicina de Botucatu - Unesp	Centro de Estudos de Venenos e Animais Peçonhentos da Unesp (CEVAP)	https://ensaiosclinicos.gov.br/rg/RBR-9mbdj3	<NULL>	Sign the term of free and informed consent; patients 18 years of age or older, of both sexes; chronic venous disease with chronic venous ulcers evidenced by one or more of the following signs: hyperpigmentation of the distal third of the lower limb, stasis eczema,  lipodermatosclerosis, varicose veins; one or more ulcers whose time evolution is minimum of 6 weeks and a maximum of 5 years; display the sum of the areas of the ulcers of both members between 5 and 60 square centimeters, at least one ulcer whose major area is above 5 square centimeters; do not use the following drugs in the last two weeks prior to screening: venotonics,  pentoxifylline, fibrinolytic drugs; Available to attend once a week for treatment.	"Leg ulcers of other etiologies ( causes hematological , neoplastic , infectious , among others) ; use of anticoagulants ; infected ulcers , or associated with erysipelas , cellulitis or lymphangitis; ulcer with critical colonization , ie ,large amount of exudate and / or foul and / or yellowish staining of the wound bed and / or green and / or red opaque odor and / or friable granulation tissue ; necrosis in the ulcer bed ; devitalized background with ulcer covering all your bed; venous ulcers associated with peripheral arterial disease that is characterized when the systolic ankle-brachial index is less than 0.9 and / or absence of distal pulses; being unable or does not wish to remain with compressive treatment of lower limb for seven days ; known or suspected pregnancy;
values coagulation outside the normal range ( Activated partial thromboplastin time &gt; 1.4 and international normalized ratio &gt; 1.4 ); women of childbearing potential not using contraception."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4msydx	Perineal massage during pregnancy for prevention of perineal trauma	Recruiting	Intervention	2016-09-13	<NULL>	<NULL>	1004	Perineal Massage during pregnancy for prevention of perineal trauma at birth: quantitative and qualitative approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-12	Programa de Pós-graduação em Enfermagem da Universidade Federal de Santa Catarina - PEn/UFSC	Programa de Pós-graduação em Enfermagem da Universidade Federal de Santa Catarina - PEn/UFSC	https://ensaiosclinicos.gov.br/rg/RBR-4msydx	<NULL>	Pretend to give birth in one of the two participating hospitals; gestational age less than or equal to 35 weeks; single pregnancy, low risk pregnancy, with a live fetus; refer that she is available digital perineal massage daily 5 - 10 min; want to have vaginal delivery; ability to understand, read and speak in Portuguese; ability to understand the instructions of the perineal massage.	Previous cesarean section indication in labor; restriction of severe fetal growth; premature birth; elective cesarean indication ; fetal malformation; placenta previa; presentation not cephalic at birth; pre eclampsia; active genital herpes lesion after 34 weeks gestation; injury genital HPV at delivery; allergy almond oil; already be performing perineal massage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-64s9ts	Tibial nerve electrical stimulation for urinary incontinence in older women	Recruitment completed	Intervention	2016-09-13	<NULL>	<NULL>	1005	Long term efficacy transcutaneous tibial nerve electrical stimulation for Urge Urinary Incontinence in older women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-05	Lucas Schreiner	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-64s9ts	<NULL>	"Urge urinary Incontinence
Women older than 60 years old"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-57xtk7	Efficacy of a physical exercises protocol for legs in patients with venous chronic insufficiency	Recruiting	Intervention	2016-09-19	<NULL>	<NULL>	1006	Efficacy of a physical exercises protocol for lower limbs in patients with venous chronic insufficiency- Clinic trial randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Universidade Federal do Rio Grande do Norte	Hospital Universatário Onofre Lopes- HUOL	https://ensaiosclinicos.gov.br/rg/RBR-57xtk7	<NULL>	individuals of both genders; aged between 35 to 69 years; diagnosed with Chronic Venous Insufficiency; ranked by criteria CEAP 2-6 without peripheral arterial disease associated, ankle index brachial between 1.3 and 0.9; with test ecco-doppler vascular venous	subjects who did not agree to participate in this study; who presented ulcers with a diameter greater than 4 cm or with clinical signs and / or confirmed diagnosis of infection; who are unable to attend the physiotherapy service twice a week and / or show inconsistent clinical manifestations with performing exercises such as congestive heart failure (class 3 or 4), angina, recent venous thrombosis, limiting musculoskeletal disorders or who have difficulty in understanding the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-2q5yjx	Effectiveness and safety evaluation of biomembrane hemicellulose versus curative collagenase in the treatment of chronic venous ulcers	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1007	Biomembranse of hemicellulose dressing versus collagenase in the treatment of chronic venous ulcers: randomized clinical trial, open and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-08	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-2q5yjx	<NULL>	"Sign the consent form; ge above 18 years; of both sexes; Venous chronic disease with venous chronic ulcer evidenced by one or more of the following signs: Hyperpigmentation of the distal third of the lower limb; stasis eczema; lipodermatosclerosis; varicose veins; One or more ulcers whose minimum evolution time is 6 weeks; present ulcer whose largest size is linear up to 20cm; Ulcers do not occur throughout the circumference of the member
Do not use venotonics drugs; pentoxifylline and fibrinolytic drugs in the last two weeks before the study"	"Having other etiologies ulcers (peripheral arterial disease, causes hematologic, neoplastic, infectious, etc.); Ulcer whose largest linear size is more than 20cm; Ulcers occurring throughout the limb circumference;
Infected ulcer, or when combined with erysipelas, cellulitis or lymphangitis;
Ulcers with critical colonization, or large amounts of exudate and/or foul odor and/or color of the green bed; Necrosis presence in ulcer bed; Venous ulcers associated with peripheral arterial disease that is characterized when the ankle-brachial systolic index (ABI) is less than 0.9 and / or absence of distal pulses, mainly tibioso; History of hypersensitivity to the proposed treatments"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4wk4b3	Influence of an exercise program on cardiac function of patients with Stroke.	Not yet recruiting	Intervention	2016-09-19	<NULL>	<NULL>	1008	Influence of an exercise program on cardiac remodeling and functional capacity of patients with Stroke.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Faculdade de Medicina de Botucatu (FMB) - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; (UNESP)	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4wk4b3	<NULL>	Will be included participants older than 18 years; both sexes; ischemic stroke or TIA; modified Rankin scale (mRS less or equal 2); chronic phase (6 to 12 months of the onset of symptoms); clinically stable for the study after medical approval.	Patients with hemorrhagic stroke; mRS more than 2; uncontrolled hypertension (systolic blood pressure more than 150 mm Hg); history of angina in the last three months; uncontrolled epilepsy; heart rate of persistent atrial fibrillation or permanent and/or rate of artificial pacemaker; presence of mitral and/or aortic valvular stenosis; presence of heart failure grade IV - stage D; chronic obstructive pulmonary disease (COPD); life expectancy less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-6g3ngr	The effect of aerobic exercise training with intramuscular proteins in obese individuals with insulin resistance	Recruitment completed	Intervention	2016-09-19	<NULL>	<NULL>	1009	The effect of aerobic exercise training on intracellular signaling pathways and heat shock protein 72 (Hsp72) in obese individuals with insulin resistance	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-6g3ngr	<NULL>	Body mass index equal to 30kg/m2 or superiror, non smokers and physically inactive. Volunteers should still provide stable body weight in the 3 months preceding the study, did not participate in programs to reduce weight in the last six months and not using drugs that can affect metabolism. For the group of resistant insulin, volunteers must submit insulin resistance evaluated from laboratory tests.	Reporting the presence of acute or chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-7zcp2n	Success of Endodontic Treatement of anterior teeth with Reciproc system instruments	Recruiting	Intervention	2016-09-20	<NULL>	<NULL>	1010	Reciproc system for the Endodontic Treatment of anterior teeth with Peripical Lesion	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-04	Universidade Federal de Sergipe	Universidade Estadual de Montes Claros - UNIMONTES	https://ensaiosclinicos.gov.br/rg/RBR-7zcp2n	<NULL>	Volunteers with anterior teeth presenting pulpal necrosis and radiographic evidence of apical periodontites whose diameter is higher than 2mm; that agree to paticipate and sign the informed consent sheet.	volunteers with teeth that will need crow placement due to advanced destruction; volunteers with a pre-existing health or oral condition that puts him at risk during the trial;  pregnant or breast feeding; volunteers with generalized periodontal desease or periodontal desease affecting the tooth to be included; volunteers allergic to any of the substances used during endodontic treatment; volunteers whose elegeble teeth has not completed its root formation, and , therefore, has an open apex; volunteers whose elegeble teeth presents radiogtaphic evidence of internal or external root resorption; volunteers whose elegible teeth has a calcified root canal space or has allready been submitted to root canal treatment; voluntters with a history of antibiotic, anti-inflamatory or analgesic use 15 days before endodontic treatment is to be performed; volunteers who have to have antibiotics prophylaxis due to bacterial endocarditis; volunteers whose elegible tooth has vital pulp tissue, even in the presence of a radiographic lesion; whose elegible teeth shows signs of root fracture during endodontic procedure; when accidents occur during endodontic procedure such as root perforation and file separation; teeth whose procedure can not be completed in a single visit due to incapacity to dry the canal (inflammatory exudate or heavy bleeding); patients that do not return to follow-up evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-4zdbbq	Effectiveness of elastic bandage in sedentary women with knee pain.	Data analysis completed	Intervention	2016-09-20	<NULL>	<NULL>	1011	The clinical efficacy of Kinesio Tape for Patellofemoral Pain Syndrome in sedentary women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-4zdbbq	<NULL>	"Female patients , aged between 18 and 43 years;
Clinical diagnosis of PFPS , unilateral or bilateral;
Inactive or irregularly active , according to the criteria of the International Physical Activity Questionnaire ( IPAQ );
History of anterior knee pain for at least 3 months;
Report increased pain in at least two activities related to PFPS , such as up and down stairs , jump , kneel , stand with the knee flexed for long periods or pain palpation of the medial or lateral facet of the patella;
BMI &lt; 29.9 ."	"Osteoarthritis in any degree;
Previous surgery in the lumbar spine , hip, knee , ankle or foot;
BMI&gt; 29.9;
Active or very active, according to the IPAQ criteria;
Patellar or quadriceps tendinopathy;
Patellofemoral instability ( PFI );
Traumatic or atraumatic patellar dislocation;
Ligamentar or meniscal lesion diagnosed clinically or by complementary exams;
Sensitivity to the material used ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6x9gc8	The effects of physical therapy resources in the skin temperature of the abdominal region	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1012	Thermographic evaluation of abdominal region between different physical therapy dermatofuncionais resources	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	UNIFAL-MG - Universidade Federal de Alfenas-MG	UNIFAL-MG - Universidade Federal de Alfenas-MG	https://ensaiosclinicos.gov.br/rg/RBR-6x9gc8	<NULL>	40 college females; aged between 18 and 30 years; white race; presence of abdominal adiposity observed by the presence of protrusion of abdominal region even when the abdominal contraction with the patient standing; BMI classified as normal (between 18.5 and 25 kg / cm2) as overweight or (25 and 30).	Women in dermatofuncional treatment to reduce localized adiposity; patients with presence of cardiac; respiratory disease; diabetes mellitus; hypertension and cancer; Patients unable to provide a sensitive or changes in skin sensitivity feedback.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-5vrgch	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1013	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde Vitória / ES	https://ensaiosclinicos.gov.br/rg/RBR-5vrgch	<NULL>	be aged between 30-75 years; Be in possession of Diabetes Mellitus Type II only; Be in drug treatment for at least 1 year properly prescribed (to be confirmed with the medication of revenue); Report difficulties in glycemic control, regular saving measures higher than recommended by the Brazilian Society of Diabetes (postprandial up to 180mg / dl).	have any of the lower limb amputee or part thereof (due to the location of the selected acupoints to the treatment protocol); Be insulin ; Being a smoker;Be alcoholic; Be in drug treatment for other diseases including obesity ; Be making specific diet for weight loss; Practicing regular physical activity; Be in possession of cancer; Being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9xrw6x	Study with dabrafenibe, a BRAF inhibitor, in combination with trametinibe, a MEK inhibitor, compared to two placebos (inactive medicaments) in the treatment of positive melanoma V600E/K BRAF mutation after surgery	Recruitment completed	Intervention	2016-09-22	<NULL>	<NULL>	1014	BRF115532 - A study Phase III, randomized, double-blind, dabrafenibe (GSK2118436) in combination with trametinibe (GSK1120212) versus two placebo in the adjuvant treatment of high-risk melanoma with BRAF mutation positive V600, after surgical resection	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-01-08	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9xrw6x	<NULL>	"Completely resected histologically confirmed high-risk, stage IIIa, LN metastasis more than 1 mm, IIIb or IIIc cutaneous melanoma determined to be V600E/K mutation positive by a central laboratory.  Patients presenting with initial resectable lymph node recurrence after a diagnosis of Stage I or II melanoma are eligible;
Surgically rendered free of disease no more than 12 weeks before randomization;
Recovered from definitive surgery, e.g. no uncontrolled wound infections or indwelling drains;
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1;
Adequate hematologic, hepatic, renal and cardiac function."	"Known mucosal or ocular melanoma or the presence of unresectable in-transit metastases;
Evidence of distant metastatic disease;
Prior systemic anti-cancer treatment and radiotherapy for melanoma; prior surgery for melanoma is allowed;
History of another malignancy or concurrent malignancy including prior malignant melanoma; Exceptions to this include: Patients who have been disease-free for 5 years or patients with a history completely resected non-melanoma skin cancer or successfully treated in situ carcinoma are eligible, for example cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ, multiple primary melanomas, or other malignancies for which the patient has been disease free for more than 5 years;
History or current evidence of cardiovascular risk;
History or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3d7yy4	Effect of Strength Training on the activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1015	Effect of Strength Training on the Activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3d7yy4	<NULL>	Patients must have a diagnosis of heart failure for at least six months; not have been admitted in two months; diagnosed as functional classes I, II, III, Second NYHA; left ventricular ejection fraction at rest &lt;45% rated by the echocardiogram; hemodynamic stability for at least two months; medication with optimal doses for at least two months; Body mass index (18.5 to 29.9 kg / m²); not present clinical history indicative of respiratory disease	Patients with worsening exercise tolerance or HF symptoms during the last 3-5 days; incapacidade de compreender ou realizar os exercícios; increase in body weight within 24 hours more than one kilogram; significant exercise-induced ischemia; present atrial fibrillation; decreased blood pressure&gt; 20 mmHg during exercise; Systolic pressure at rest&gt; 160 mmHg and diastolic&gt; 90 mmHg; Complex arrhythmias at rest or arrhythmias that develops with exercise; third-degree atrioventricular block; Resting heart rate&gt; 100 bpm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-7nr6sy	Treating blood-less legs with infra-red radiation.	Recruitment completed	Intervention	2016-09-22	<NULL>	<NULL>	1016	The effect of far-infrared emitting socks on claudicant patients - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-12	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7nr6sy	<NULL>	Patients with calf intermittent claudication, between 18 and 90 years old, with clinical evident stenosis or occlusion of the external iliac artery or common or superficial femoral artery; ankle-brachial index at or less than 0,9.	Impossibility to deambulate freely; DVT active or in the past; cancer; diabetic neuropathy needing specific treatment; major amputation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-446mrc	Physiotherapy in pubalgy in soccer players	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1017	Physioterapeutic treatment of pubalgy in a professional soccer player: case study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-12	Universidade Vale do Rio Doce	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-446mrc	<NULL>	Professional soccer player; age between 18 and 22 years old; active in the midfield position; presenting chronic pubalgy symptoms.	Athletes from different sports of football; amateurs Athletes; women; older than 22 years; asymptomatic; athlete who is having physiotherapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3yxds4	Effects of exercise training on the human body	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1018	Time-course of organic adaptations in response to exercise training in aging	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	Programa de Pós-Graduação em /gerontologia, Faculdade de Ciências Médicas, UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-3yxds4	<NULL>	Individuals from both sexes; non-active (frequency of regular physical activity less than two sessions per week); Did not participate in any regular training program over the last 6 months preceding the beginning of the experiment; to be normotensive, or grade 1 (systolic blood pressure: 140 to 149 mmHg or diastolic blood pressure: 90 to 99 mmHg), or 2 (systolic blood pressure 160 to 169 mmHg or diastolic blood pressure: 100 to 109 mmHg) of controlled hypertension (according to the medical report of the participants);  have clinical evaluation report carried out by a physician (general physical examination, cardiological and clinical exercise testing) authorizing the practice of physical activity.	Obesity greater than grade 2 (body mass index up to 35); coronary artery disease, diabetes mellitus insulin-dependent; chronic obstructive pulmonary disease; limiting osteoarticular disease; peripheral vascular disease; smokers; in use of medications that may interfere with physiological responses to tests, such as beta-blockers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3d7rp9	Is there difference to do respiratory exercise controlling the time or how often does it?	Recruiting	Intervention	2016-09-23	<NULL>	<NULL>	1019	Is there a difference in cardiorespiratory variables to prescribe the respiratory exercise by time or repetitions?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-05	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3d7rp9	<NULL>	Availability of time for implementation of the proposed protocol; age equal to or greater than 18 years; both genders; healthy subjects; understanding and ability to perform respiratory tests.	Smoking Cessation; acute myocardial infarction; dizziness; altered ocular pressure; use of heart pacemaker; tympanic perforation; lung diseases (restrictive, obstructive or mixed) or systemic disease involving the respiratory and cardiac and neurological system; the absence of one or more times during the protocol; intense physical exercise for more than three time for week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6t4qmn	self-care economic evaluation of patients with type 2 diabetes mellitus	Recruiting	Intervention	2016-09-23	<NULL>	<NULL>	1020	Pharmacotherapeutic strategy for individual empowerment of patients with diabetes mellitus type 2 - pharmacoeconomic analysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Universidade Federal São João Del-Rei	Universidade Federal São João Del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-6t4qmn	<NULL>	Group Intervention: Patients with DM2 registered HIPERDIA. Aged 18 years. Both sexos.Residentes in the areas of coverage of ESFs belonging to the study. Graduates of EIEF. Low and moderate cardiovascular risk, according to the Framingham score. Control Group: Patients with DM2 registered HIPERDIA. Age less than 18. Both sexes. Residents in the areas covered by ESFs belonging to the study. No participant in any meeting of EIEF. Low and moderate cardiovascular risk, according to the Framingham score.	Group Intervention: Participants from other intervention projects related to DM. reduced cognitive ability, classified by the team of the FHS, as unable to reproduce the transferred information. Control Group:Indivíduos participants from other intervention projects related to DM. Patients with reduced cognitive ability, classified by the ESF team, as unable to reproduce the transferred information. Patients without result HbA1c in the reference period for data collection the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-4752n8	Effectiveness of topical use of flouride and toothbrushing in the control of white spot carious lesions.	Data analysis completed	Intervention	2016-09-26	<NULL>	<NULL>	1021	Effect evaluation &quot;in vivo&quot; of the fluoride ion and toothbrushing on White spot enamel lesions.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-12	UFRN - Universidade Federal Do Rio Grande do Norte	UFRN - Universidade Federal Do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4752n8	<NULL>	Healthy volunteers; between 12 and 18 years old; who needed as part of the orthodontic treatment of extraction of the first two upper premolars and first two lower premolars; they were healthy and without damage to the labial surface; who were not participating in a preventive program involving the use of fluoride.	Volunteers who were not wearing orthodontic braces; Volunteers using fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6hbztw	Use of block of beta tricalcium phosphate to enhance the bone disponibility for the implants placement	Recruiting	Intervention	2016-09-28	<NULL>	<NULL>	1022	Use of block of beta tricalcium phosphate to enhance the bone disponibility in edentulous alveolar ridges: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia de Araraquara-Unesp	Faculdade de Odontologia de Araraquara-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6hbztw	<NULL>	Having aged between 18 and 60; presence of edentulous alveolar ridges of less than 4 mm thick, which characterizes the need to increase bone availability for subsequent implants placement; good systemic health; provide at least 1 year of healing of the dental post-extraction socket.	Smokers and former smokers; diabetes;chronic or aggressive periodontitis ; users of medications wich alters the bone metabolism; cronical users of anti-inflammatories and antibiotics; bruxism; alcoholics; chemical dependents; pregnant or who wish to become pregnant in the next year; history of radiotherapy  in the head and neck regions; patients with diseases affecting bone metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9y5tbp	Efficiency of bolus insulin therapy versus continuos infusion intravenous insulin in the liver transplant	Data analysis completed	Intervention	2016-09-29	<NULL>	<NULL>	1023	Efficiency of the bolus intravenous insulin therapy versus continuos infusion intravenous therapy in patients submitted to liver transplant	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9y5tbp	<NULL>	Patient in anesthesia recovery room due to liver transplant; both sex; between 18 and 70 years old; blood glucose at least 180 mg/dl	Patients with severe disfunction after liver transplant; blood glucose values under 150 mg/dl; death at first 48 hours; double transplant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3qqkss	Effect of exercise on strength and balance of diabetic patients	Recruiting	Intervention	2016-09-30	<NULL>	<NULL>	1024	Comparative evaluation of the effect of aerobic, resistance and combined training on muscle strength and balance in individuals with type 2 diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3qqkss	<NULL>	Individuals with type 2 diabetes mellitus; diagnosis of diabetes for at least 3 years; with diabetic neuropathy; both sexes; aged 50 years; sedentary; able to walk without assistance or supervision from others;	Presence macroangiopathy; history of neurological diseases, muscular rheumatism or outside the etiology of diabetes; presence of uncontrolled hypertension; lack the physical activity program; smokers; dependent on alcohol and illicit drugs; change in the use of corticosteroids, oral hypoglycemic agents or any hypoglycemic diet two months before the start of the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9gnxv3	Influence of different treatment forms with low temperature on the muscle and heart function in recovery after effort	Recruiting	Intervention	2016-09-30	<NULL>	<NULL>	1025	Influence of different cryotherapy protocols on muscle performance and cardiac autonomic modulation in acute post-effort recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9gnxv3	<NULL>	Healthy; male; aged between 18 and 35 years; students in undergraduate or postgraduate public higher education institutions or private.	Presence of musculoskeletal injury in dominant leg in the last two months; Raynaud&apos;s disease; allergies to cold; labor or physical activity that requires effort level in intensity that makes it impossible to volunteer at the time of survey participation is in muscular condition of homeostasis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-59ygr8	Applications of physioterapy equipments in low back pain	Recruiting	Observational	2016-06-14	<NULL>	<NULL>	1026	Application of electrothermotherapies resources in patientes with lumbar pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-59ygr8	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	"Physical activity people with more than 6 weeks
It has been realized lumbar surgery; it not have clinical diagnosis of lumbar pain and when the ethiology was not known; it don´t show irradiated lumbar pain to gluteus and lower limbs, thermic and sensibility alteration, pregnant woman, kidney problem; patients with pace marker; skin lesions; patients who utilized analgesic medication before 48 hours of application of resource."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3y357v	Comparison of tracheal tubes for children&apos;s tracheas intubation	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1027	Comparison of the use of uncuffed tracheal tube versus cuffed tracheal tubes filled with saline solution, lidocaine or air in pediatric patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-03	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3y357v	<NULL>	Children undergoing general anesthesia; aged between 3 and 13 years; both genders; physical status 1 or 2 according to American Society of Anesthesiologists; minor or medium level surgery	Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomised; previous presence of stridor or dysphonia; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts at tracheal intubation; use of corticosteroids during the perioperative period; the use of local anaesthetic agents administered through a route other than that used to fill the tracheal tube cuffs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-2s7ptv	Associaton of products for tooth sensitivity treatment	Recruitment completed	Intervention	2016-10-04	<NULL>	<NULL>	1028	Analysis of products association for dentin hypersensitivity treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	https://ensaiosclinicos.gov.br/rg/RBR-2s7ptv	<NULL>	Healthy volunteers; both genres; presence of dentin exposure lesions with clinical diagnosis of moderate or severe tooth sensitivity; good oral hygiene	Presence of cavities, cracks or enamel fractures; extensive  or unsatisfactory restorations; recent restorations involving the labial surface; dentures or orthodontics; presence of periodontal disease and/or parafunctional habits; systemic disease and / or severe psychological; constant use of analgesic and / or anti-inflammatory or allergic response to dental products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-4br6q5	The effect of mindfulness meditation on crack cocaine users	Not yet recruiting	Intervention	2016-10-06	<NULL>	<NULL>	1029	Effectiveness  of  mindfulness-based  stress  reduction  as  an  adjuvant strategy for the 12 steps program in relapse prevention among crack cocaine users: a randomized clinical trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2016-10-05	Escola de Enfermagem de Ribeirão Preto	Escola de Enfermagem de Ribeirão Preto (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-4br6q5	<NULL>	Be followed up in the TC for at least 30 days (crack abstinent); be in treatment in the TC due to the problematic use of crack (self-reported and confirmed by a TC profissional); fill the substance disorder criteria of The Diagnostic and Statistical Manual of Mental Disorderss, 5th Edition (DSM-V) 31; and score greater than 25 on the Mini-Mental State Examination (MMSE)	Presence of psychotic symptoms reported by TC professionals or identified by the researcher during the interview to the randomization of the sample; and report health problem that prevents the collection of cortisol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-555p8y	Heart function during the bed bath of people with acute myocardial infarction	Recruiting	Intervention	2016-10-06	<NULL>	<NULL>	1030	Oxygen uptake by myocardial and hemodynamic aspects during the bed bath of patients with acute myocardial infarction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal Fluminense	Hospital Icaraí	https://ensaiosclinicos.gov.br/rg/RBR-555p8y	<NULL>	Patients sub-group with acute myocardial infarction: Acute Myocardial infarction confirmed by myocardial necrosis markers Dosage (CK-MB and / or troponin), electrocardiogram (ECG) and echocardiogram Up to 48 hours of pain home chest; Older than 18 years; Killip 1 and 2. Subgroup of patients without cardiac involvement diagnosis: Patients admitted to the search scenario For hospitalization Cause not cardiac and without medical diagnosis of cardiovascular disease.	Sub-group of patients with acute myocardial infarction: Patients undergoing cardiac surgery; Chronic heart failure; septic shock; Regurgitation of the aortic valve or defective septum; severe aortic Sclerosis, aortic prosthesis; severe hypertension (MAP greater than 130 mmHg); tachycardia with high heart rate at 200bpm; a height 120 cm or greater than 230cm; weight less than 30 kg or more than 155kg; presence of aortic balloon. Subgroups of patients without cardiac involvement diagnosed: burns, dermatitis and / or polytrauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-75s4sn	Intubation confirmation in newborns with volumetric device compared to the clinical method	Not yet recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1031	Neonatal intubation confirmation with the use of pedflow volumetric device and the clinical method	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	hospital das clínicas de pernambuco	hospital das clínicas de pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-75s4sn	<NULL>	newborns that in selected hospitals requiring intubation in presence one of the researchers	newborns weighing less than 500 grams , with genetic syndromes , poor facial formations or in use of neuromuscular paralytic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6tbygn	The effect of electrical stimulation in people with shoulder pain	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1032	The effect of electrical stimulation point microcurrent in individuals with Chronic Myofascial Pain Syndrome in the upper trapezius muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6tbygn	<NULL>	Individuals aged 18 to 40, that are experiencing persistent, spontaneous pain in the upper trapezius muscle region for more than 3 months. On physical examination, individuals must have at least one active trigger point in one or both sides of the muscle. The inclusion criteria for the presence of active trigger point in upper trapezius muscle are: Presence of a palpable taut band in the muscle; Presence of a hypersensitive lump in the taut band of muscle; Standard playback typical trigger point referred pain in response to palpation; Standard spontaneous presence of typical referred pain and / or recognition that pain patient and family; Pain of at least 3 cm on a visual analogue scale (VAS) from 0 cm (no pain) to 10 cm (worst pain imaginable).	Individuals that are experiencing muscle pain due to fibromyalgia; cervical radiculopathy; neck pain; degenerative cervical changes; History of surgery in the cervical spine or shoulder; history of fracture; Tendinitis in the neck and shoulder area; Cancer; Cervical myelopathy; atypical facial neuralgia; myopathy; Rheumatism; Multiple sclerosis; Tuberculosis; recent medication change; Use of anti-inflammatory or pain medications; physical therapy interventions (acupuncture, chiropractic, massage); weight lifters; Other chronic pain conditions (chronic fatigue syndrome and Lyme disease); cardiac pacemakers; Pregnancy; Menstrual period; uncontrolled hypertension; neurological or psychiatric disorders; Disorders of the skin and vascular disorders; sensitivity changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6qr9xx	Effects of supplementation of some nutrients, in elderly, on the inflammation, the muscle, the bone and the body fat	Data analysis completed	Intervention	2016-10-10	<NULL>	<NULL>	1033	Effects of nutritional supplementation on intestine permeability, systemic inflammation and body composition consequences in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Centro de Saúde Escola Geraldo Horácio de Paula Souza	https://ensaiosclinicos.gov.br/rg/RBR-6qr9xx	<NULL>	Elderly above 60 and below 90 years old; both genders; independent and non-institutionalized; they have to fill at least one of the following criteria of frailty: non-intentional body weight loss in the last six months; exhaustion evaluated by a geriatric depression scale; grip strength below the expected values; gait speed below the expected values; reduced energy expenditure.	Presence of acute or chronic intestinal inflammatory disease; current use of antibiotics; current use of supplements of protein, hormones or other substances driven to enhance muscle mass; current use of synbiotic, probiotic or prebiotic substances; having caner or any inflammatory disease in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-22vxvq	Effect of stimulation with electrical current associated with exercise in stroke: randomized controlled clinical trial	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1034	Effect of interferential current associated with exercise in stroke: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-31	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-22vxvq	<NULL>	Patients with stroke in mild or moderate spastic phase, both genders, aged 30 to 70 years and without physical therapy concomitant during the training period.	Patients who present score less than 24 on the Mini-mental exam, psychiatric condition, cognitive decline or dementia influencing the communication process, musculoskeletal, neuromuscular, or recent cardiopulmonary disorder, patients who can not walk and sit independently, present anesthesia in the trunk region or refuse to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-365tkt	Benefit of physiotherapy with semi-supervised training of dual task in motor performance and cognitive for people with Parkinson&apos;s disease	Recruitment completed	Intervention	2016-10-13	<NULL>	<NULL>	1035	Effectiveness of physiotherapy with semi-supervised training of dual task in motor performance and cognitive for people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Poliana Penasso Bezerra	Universidade Federal de Santa Catarina (centro do pesquisador)	https://ensaiosclinicos.gov.br/rg/RBR-365tkt	<NULL>	Individuals of both sexes; aged 40 to 70 years; diagnosed with Parkinson&apos;s disease; stage 1-3 Hoehn-Yard; able to walk independently; not be modified in drug treatment during participation in the study.	Other neurological disorders as heart disease and / or severe cognitive impairment that could affect the understanding and / or to indicate the completion of the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-86gd8n	Evaluation of Heart Rate With Equipment That Extends Sound of Heartbeats in Newborn in the Delivery Room	Not yet recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1036	Evaluation of Heart Rate With Sonar in Newborn in The Delivery Room	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-86gd8n	<NULL>	Newborns with gestational age greater than or equal to 34 weeks, in which at least one of the researchers is present in their delivery.	Newborns with bad formation and those requiring positive pressure ventilation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-83wwpx	Assessment of the influence of the use of live microorganisms on the absorption and production of soy isoflavone substances in women with menopausal symptoms	Recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1037	Assessment of the influence of probiotics in absorption and production of soy metabolites in menopausal women with climateric symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83wwpx	<NULL>	Women between 40 and 60 years of age; latest menstrual period has occurred at least 12 months previously; follicle-stimulating hormone (FSH) levels are higher than 40mIU/mL; estradiol levels are lower than 20 pg/ml;currently present symptoms of estrogen deprivation.	History of chronic conditions such as Type 2 diabetes mellitus; cardiovascular or gastro-intestinal disorders; contraindications to hormone replacement therapy; soy-intolerant; vegetarians; undergone bariatric surgery; undergone hysterectomy; undergone hormone replacement therapy; oral contraceptives; antibiotics or lipid-lowering drugs in the previous 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-9p8whf	Exercise Effect On Balance And On Falls Risk Among The Elderly Living In The Community	Not yet recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1038	Impact Of A Therapeutic Exercise Program On Physical And Functional Capacity And On Risk Of Falls Among Community Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade de Brasília	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-9p8whf	<NULL>	Elderly volunteers; aged 60 years; both sexes; residents in the community (non-institutionalized); with history of one or more falls in the previous year or at risk of falling; that agree to participate and sign the consent form.	Volunteers in bedridden or wheelchair situation; score less than 17 on the Mini Mental State; severe visual impairment; amputations or use of lower limb prostheses; neurological disease; acute crisis related to vestibular in the last month; history of recent fractures in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-4k5mtn	Human semen freezing : Effects of adding lipids and antioxidants in the quality of sperm	Recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1039	Human semen cryopreservation: effect of lipid and antioxidant supplementation on sperm viability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-20	Faculdade de Medicina de Ribeirão Preto	Invitra	https://ensaiosclinicos.gov.br/rg/RBR-4k5mtn	<NULL>	Men aged 18-40 years; able to collect the semen by masturbation ; are prior to sexual abstinence of at least two days	Semen volume smaller than 1.5 ml; concentration less than 15 million sperm / mL ; motility less than 32 %	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7qgnbn	Effects of actions to promote healthy eating and physical activity using internet technology on the health of adolescents	Recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1040	Effects of promotional activities of healthy eating habits and physical activity in adolescents, use of E-Health technology, enrolled in schools based public schools in the city of Salvador-BA	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Escola de Nutrição - Universidade Federal da Bahia	Faculdade de Farmácia - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7qgnbn	<NULL>	Adolescents 10-17 years; of both sexes; enrolled in the public school system in Salvador-Bahia	Pregnant women and people with physical trauma (fixed at the time of anthropometric measurements) and systemic diseases and birth frames, except for metabolic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-3wk3cr	Effects of physical activity  on cognitive functions (attention, memory, processing speed and  executive function), bain-derived neurotrophic factor (BDNF) and cortisol levels in older women.	Recruitment completed	Intervention	2016-10-17	<NULL>	<NULL>	1041	Effects of physical activity  on cognitive function and BDNF and cortisol levels in older women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-30	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3wk3cr	<NULL>	Ages between 60 and 90 years; not being physically active in the last 6 months; at least 4 years of formal education; present a medical certificate permiting the participation in the physical activity protocol.	Previous  or  current  history of neurological diseases; dementia; major unstable medical conditions; pathological conditions that modify cortisol and BDNF levels; visual and hearing dysfunctions; use of medications that interfere with cognitive functions, BDNF levels or HPA axis; previous or current drug abuse; lower-limb amputation or bone fractures in the past 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-5fdph6	Effects of green tea on physical conditioning in young untrained	Not yet recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1042	Velocity of ventilatory anaerobic threshold and heart rate variability after acute supplementation of the main componets of green tea in young untrained: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5fdph6	<NULL>	Youngs of both genders, aged between 20-35, insufficient active by International Physical Activity Questionnaire (IPAQ)	"No additional orthopedic deficiencies impairing ambulation
Diabetic individuals
Individuals with cardiopathies
Individuals with body mass index maior que 30 Kg/m2
Regular caffeine or green tea drinkers
Individuals with intolerance to caffeine or green tea"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-3my65z	Evaluation of dental sensitivity at-home whitening with different viscosities	Recruitment completed	Intervention	2016-10-17	<NULL>	<NULL>	1043	Evaluation of the influence of at-home bleaching with different thickeners in dental sensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Odontologia de Piracicaba - Unicamp	Faculdade de Odontologia de Piracicaba - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-3my65z	<NULL>	Patients aged between 18-30; Presenting teeth color in the beginning of treatment of A3 and B4; Presence of all the upper and lower anterior teeth; Dental pigmentation resulting from consumption of food colorants; Ability to understand and respond to pain scales used.	"Smoker; Dental trauma in the last 6 months; History of use of any tobacco product derived from the past 30 days;  Prior bleaching treatment use of orthodontic appliances or prostheses; Restoration of anterior teeht; Patients with parafunctional habits; Pregnant and lactating; Patients with generalized tooth sensitivity; Discoloured teeth with tetracycline and fluorosis;Periodontal disease; Presence of dental caries; 
Gingival recession more than 1mm."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7jcvv4	Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529	Recruiting	Intervention	2016-10-19	<NULL>	<NULL>	1044	AMB114588 - An open-label, long term extension study for treatment of Pulmonary Arterial Hypertension in paediatric patients aged 8 years up to 18 years who have participated in AMB112529 and in whom continued treatment with Ambrisentan is desired	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2011-06-21	GlaxoSmithKline	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7jcvv4	<NULL>	Volunteers who participated in the study AMB112529; with diagnosis of Persistent  Pulmonary Arterial Hypertension;  Male or female;	Subjects who were withdrawn from ambrisentan in Study AMB112529;subjects with severe renal impairment;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6v9sjj	Effects of physical exercise in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2016-10-19	<NULL>	<NULL>	1045	Effects of elastic resistance training on morphological and functional parameters in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Júlio Mesquita Filho	Universidade Estadual Paulista Júlio Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6v9sjj	<NULL>	Patients must have a diagnosis of chronic obstructive pulmonary disease; both genders; tifennau index less than 70 percent; be aged between 45 and 70 years; being clinically stable.	Cardiac comorbidities and musculoskeletal disorders; exacerbation within one month of the initial evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-8tsmfr	Efectiveness evaluation of Atraumatic Restorative Treatment with modified cement in children	Recruitment completed	Intervention	2016-10-19	<NULL>	<NULL>	1046	Evaluation of cost-benefit of Atraumatic Restorative Treatment with glass ionomer cement added cellulose nanocrystals in Brazilian children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8tsmfr	<NULL>	Good general health; Presence of at least two vitals primary molars, without painful symptomatology	Uncooperative patients and/or with neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7bk8rf	Comparison between strenght training (muscular strenght) and power training (muscular power) in functional capacity in elderly	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1047	Functional capacity of pre-frail elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-05	Centro Universitário do Rio Grande do Norte	Centro Universitário do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7bk8rf	<NULL>	age between 60 and 75 years old; female; have not practiced any kind of regular exercise (2 days per week) within 6 months prior to study entry.	with stage 2 hypertension (systolic 160 mmHg and diastolic 100 mmHg); and present musculoskeletal injury that prevented the completion of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-776d9s	Influence of an educational manual on the support provided by the companion in the delivery room	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1048	Effects of an educational manual on the support provided by companion during delivery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-776d9s	<NULL>	Accompany pregnant women are undergoing prenatal care in local search, monitor pregnant women who have normal delivery; It has been chosen by pregnant women to attend the birth in the accompanying condition; have up to four years of study	Have previous experience of witnessing the birth in the accompanying condition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7g8p6s	Effectiveness of propolis in reducing the symptoms of rheumatic diseases in humans	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1049	Propolis effectiveness of therapy in the treatment of signs and symptoms of rheumatism: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-20	Pós Graduação em Ciências da Saúde	Pós Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7g8p6s	<NULL>	Inclusion criteria were the clinical diagnosis of tendinitis; bursitis or osteoarthritis and presence of pain resulting from rheumatic disease at the time of initial evaluation. Participants did not do any treatment for rheumatism two weeks before the start or during the clinical trial; or intra-articular corticosteroid injections in the previous three months.	We excluded patients with hypersensitivity to bee toxins, obesity, pregnancy and lactation, gastrointestinal bleeding history, gastric perforation; kidney disease, liver disease; current history of alcoholism, use of anticoagulants; implant prosthesis or pacemaker; severe chronic uncontrolled (hypertension, diabetes mellitus, heart disease and other diseases that by its nature or the proposed treatment could interfere with the assessment).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-2nzf7q	Effects of intense cycling and/or strength training on health-related blood parameters in type 1 diabetes mellitus patients	Recruiting	Intervention	2016-10-20	<NULL>	<NULL>	1050	Effects of high-intensity interval training and/or strength training on inflammatory, oxidative stress and glycaemic metabolism in type 1 diabetes mellitus patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-26	Universidade Federal do Rio Grande do Sul	Instituto da Criança com Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-2nzf7q	<NULL>	Patients with type 1 diabetes mellitus(diagnosis for over five year); physically inactive (less than 150 min weekly systematic exercise in the previous three months); with glycated haemoglobin less than 10%; age between 18-40 years.	Smoking patients; they with significant loss of renal function (creatinine &gt; 1.3 mg/dL), liver failure, musculoskeletal disorders; hypertension; heart diseases; patients with retinopathy and/or recent infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-67hjmn	Use of treatment with low power laser in canker sores and skin burns caused by radiation therapy in patients with head and neck cancer	Recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1051	Use of low level laser therapy for treatment of radiation induced mucositis and radiodermatitis in patients with head and neck cancer	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-20	Univesrsidade Estadual de Montes Claros	Univesrsidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-67hjmn	<NULL>	Individuals with a confirmed histopathologic diagnosis Squamous cell carcinoma of head and neck; 2) Individuals should have at least 20 years old; Need of radiotherapy treatmentd; Agreement to participate in the study, signed the consent form.	Individuals who are not able or have limitations that prevent them from responding to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-9sp5hx	Program at school: Healthy Living, Happy Heart	Not yet recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1052	Promotion program for cardiovascular health: resources and interventions in the school network	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-04	Instituto de Cardiologia  - Fundação Universitária de Cardiologia	Instituto de Cardiologia  - Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9sp5hx	<NULL>	Children 6 to 11 years old, both genders, students from 1st to 5th grade of elementary school of public schools in the city of Frederick / RS; Children with permission of parents or guardians; Teachers and educators from public schools in the municipality of Frederick / RS representing school years 1st to 5th grade of elementary school.	Children older than 9 years who are illiterate; with cognitive or neurological deficits that prevent the completion of the questionnaires; Teachers who teach in more than one research participant school; and teachers who do not sign the Instrument of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-95crtd	Effect of expanding motor opportunities at the home environment in  infants with risk for developmental delay	Not yet recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1053	Effect of a goal-oriented training with activities and toys at the home environment of infants with environmental and biological risks to delay on neuromotor development	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-30	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-95crtd	<NULL>	Infants with social and environmental risks; infants with biological risk; low socioeconomic status; low parental education; both gender; age at 6 to 8 months old.	Infants with adequate motor development; infants who do not appear in the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-22jcgs	Schoolchildren: relationship between postural deviations, pain and level of physical activity	Recruitment completed	Observational	2016-10-21	<NULL>	<NULL>	1054	Correlation of the level of physical activity for students with the presence of postural deviations in a state school in the city of Curitiba	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Universidade Federal do Paraná- UFPR	Universidade Federal do Paraná- UFPR	https://ensaiosclinicos.gov.br/rg/RBR-22jcgs	<NULL>	Individuals enrolled in high school ; of both sexes ; aged 14-17 years;  who agree to participate;  deliver the taile ( Consent Term Informed Free and Clear ) and the IC ( Informed Consent and Clear ) duly signed .	Individuals with neurological disorders, fractures in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-89ydgj	Effects of interventions with and without interactive video games in children with developmental coordination disorder	Recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1055	Comparative analysis of the effects of intervention with and without virtual reality on the motor performance and the energy expenditure in children with developmental coordination disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-89ydgj	<NULL>	"To study the initial stage will be included children of both sexes; aged 7-10 years; who are enrolled in selected schools; whose parents have signed the Consent Agreement and Informed and children the Free Consent Term Cleared up.
For the later stage of the study children will be included from the group of those with a positive indication for TDC; which have availability to participate regularly from interventions."	At this early stage of DCD tracking will be excluded children who have a physical disability; intellectual and or sensory impairments; autism spectrum disorder; orthopedic problems or other medical condition that may compromise the identification of the DCD. Children will be excluded if they do not meet the minimum of 10 intervention sessions; showing some clinical complications or making use of drugs that precludes their participation in training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-8m8tmq	Monitoring of Patients with Heart Failure Telephone for Knowledge Improvement and Self Care	Data analysis completed	Intervention	2016-10-24	<NULL>	<NULL>	1056	Impact Telephone Monitoring in the Evaluation of Knowledge and Selfcare of Patients with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Enfermagem UERJ	Hospital Universitário Pedro Ernesto - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-8m8tmq	<NULL>	Patients with heart failure; who were hospitalized and / or searching the emergence in the last three months due to decompensation by the disease; in clinical follow-up in heart failure clinic of the University Hospital Pedro Ernesto; both sexes; older age or equal to 18 years; not present any functional problem, which prevents him from speaking, writing or interfere with cognition; have telephone contact and availability monitoring.	Heart failure patients in very advanced stage with no prospect of life (greater than or equal to 6 months); and / or with other comorbidities in terminal stage that might interfere with evaluation; Stage IV according to the functional classification of the New York Heart Association.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-29j956	Effect of diacerein in patients with diabetes treated with  antihyperglycemic drugs	Recruitment completed	Intervention	2016-10-24	<NULL>	<NULL>	1057	Effect of diacerein in metabolic control and acute inflammatory markers in patients with type 2 diabetes using andidiabetic agents.	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2014-03-10	Hospital de Clinicas de Porto Alegre	Hospital São VIcente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29j956	<NULL>	35 years old and older; HbA1c &gt; 7.5%; type 2 Diabete mellitus withou microalbuminuria and/or nephropaty; Using oral antihiperglicemic drugs(sulfonilureias and or metformin)	Pregnant and lactating women; Chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis; Use of anti-inflammatory drugs for more than 5 days in the last 3 months; Previous diagnosis of pancreatitis; Hypersensitivity to Reina (active metabolite of diacerein) and other antraquinonic derivatives (laxative); Diabetic Nephropathy and \ or kidney failure; Liver disease (transaminases&gt; 2.5 times the upper limit of normality); Severe gastrointestinal disease; Persistent diarrhea (&gt; 3 stools in 24 hours); Signs of intercurrent infection; Participation in another clinical study in past 30 days; Failure to follow the research protocol; using pioglitazone;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-7nyhhj	Effects of an intervention involving physiotherapy and physical education, performed for all ages, aimed at the physical capacity of the elderly living in the community	Recruitment completed	Intervention	2016-10-26	<NULL>	<NULL>	1058	Effects of interdisciplinary and intergenerational intervention in the community elderly mobility	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-25	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nyhhj	<NULL>	People with 60 years or more; both sexes; without health changes to indicate the practice of physical exercises	People who do not adhere to the program and present more than three fouls	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-7b399d	Training respiratory muscles really improves functional capacity in patients with spinal cord injury?	Not yet recruiting	Intervention	2016-10-27	<NULL>	<NULL>	1059	Effects of Inspiratory Muscle Training with Dynamic Resistance on Aerobic Capacity in Traumatic Spinal Cord Injury: Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-03	Rede Sarah de Hospitais de Reabilitação	Rede Sarah de Hospitais de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-7b399d	<NULL>	During a period of 10 to 12 months, we will select males; non-smokers; with traumatic SCI; with complete motor injury (ASIA A or B), between T4 and C5 levels; injured for more than 6 months; who are able to perform an arm crank exercise test in an upper limbs cyclergometer.  They will be admitted from Neurorehabilitation in spinal cord injury program from Sarah Network of Rehabilitation Hospitals Brasília.	Will not be included in the study patients with scheduled surgery; with known heart or lung diseases; athletes; or who presents acute infectious syndromes or with any clinical decompensation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-2rsxnc	Measures of indicators of attention and action expectancy during task acomplishment	Not yet recruiting	Observational	2016-10-31	<NULL>	<NULL>	1060	Attentional indicators between body action expectancy and selconsciousness in the performance in induced tasks	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-28	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2rsxnc	<NULL>	Right handed; both genders; normal or corrected to normal vision; and should not drink coffee or alcohool for up to 4 hours before the experiment	Have self report of psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-3n947j	Evaluation of malaria relapse rate in Brazil	Recruitment completed	Observational	2016-10-31	<NULL>	<NULL>	1061	Evaluation of malaria relapse rate in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3n947j	<NULL>	Positive diagnosis result (RDT, slide, PCR) and an evaluation of cure within 40/60 days in the selected areas.	"Exclusion criteria of the patient data in the analysis:
Absence of an evaluation of cure in the databank."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-9y5fbs	Use of penile clamp and quality of life in urinary incontinence after prostate surgery	Not yet recruiting	Intervention	2016-11-01	<NULL>	<NULL>	1062	Use of the penile clamp and quality of life in Urinary Incontinence After Prostatectomy: clinical trial Phase I / II	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2017-01-15	Faculdade de Enfermagem da Universidade Estadual de Campinas	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9y5fbs	<NULL>	have stress urinary incontinence; have completed prostatectomy or transurethral resection for at least one year; have satisfactory score on the Mini Mental State Examination; have normal sensation in the perineum and the penis by physical examination; perineal intact skin; good manual dexterity demonstrated with installing and removing the clamp; to read and write or come with caregiver or family member, in the case of illiterate patients.	be performing radiotherapy or chemotherapy for prostate tumor; have symptoms of urge urinary incontinence or urge incontinence; prior urodynamic study demonstrating detrusor overactivity or low compliance; present neurological disorders or other conditions that alter the perineal sensitivity, manual dexterity or change in cognitive function; provide blood flow velocity in lower systolic peak 10ml per seconds in the flaccid penis; be in use of penile prosthesis; be in the presence of urinary tract infection, but after resolution of the urinary tract infection, may be part of the survey, provided it meets the other eligibility criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-9nckrq	Effects of  physiotherapy assisted by virtual games in the recovery of daily activities and well-being of patients with kidney disease on hemodialysis	Recruitment completed	Intervention	2016-11-01	<NULL>	<NULL>	1063	Effects of  physiotherapy assisted by virtual reality in functionality and quality of life of patients with chronic renal failure in dialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de Sergipe	Clinica de Nefrologia de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9nckrq	<NULL>	Volunteer both genders; older than 18 years; sedentary; performing hemodialysis three times per week for at least three months; stable clinical condition in terms of no hospitalizations or cardiovascular events within the 3 months prior to screening; Systolic blood pressure (SBP) &lt;200 mmHg and diastolic blood pressure (DBP) &lt;110 mmHg at baseline.	Volunteers with diagnoses of pulmonary, neurological or psychiatric disorders; presence of unstable angina; recent myocardial infarction less than 6 months; symptomatic left ventricular fibrillation; decompensated heart failure; visual and / or hearing disorders; musculoskeletal limitations; hemiplegia or hemiparesis that compromise the ability to perform the exercises; hospitalization during the study period; neoplasms in current chemotherapy and / or radiotherapy; diagnosis of infection by the human immunodeficiency virus; scheduled kidney transplant or already carried out; volunteers who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-2tfwq3	Effect of diacerein on kidney function, glucose and blod fat metabolism alteration and acute inflamation indicators in type 2 diabetic patients with kidney disease	Recruitment completed	Intervention	2016-11-07	<NULL>	<NULL>	1064	Effect of diacerein on renal function, metabolic control and acute inflamatory parameters in type 2 diabetic patients with nephropaty  - randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-03-07	Universidade Federal do Rio Grande do Sul	Hospital São VIcente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2tfwq3	<NULL>	Patients from 30 to 80 years old, with type 2 diabetic with microalbuminuria. macroalbuniria and or diminished glomerular filtration rate (GFR - stages 1 and 2); HbA1c from 7.5 to 10%; in regular use of inhibitor Angiotensin Converting Enzyme or Angiotensin Receptor Blocker; Body mass index bellow 40kg / m²; do not make use of pioglitazone; Use of antihyperglycemic medications; Acceptance to participate and to sign informed consent;  Patients seen in the outpatient medical clinic of the Faculdade de Medicina of  Universidade de Passo Fundo	Pregnant and lactating women; presence of chronic inflammatory diseases such as arthritis, colitis; Infectious Disease like  tuberculosis; use of anti-inflammatory drugs for more than five days in the last three months; previous diagnosis of pancreatitis; hypersensitivity to reigns or its correlates (laxative); Smoking; severe liver disease (transaminases major than 2.5 times the upper limit of normal); severe gastrointestinal disease; participation in another trial in the past 30 days; failure to follow the research protocol requirements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-4vn75c	The physical therapy in the treatment of striae in skin	Recruitment completed	Intervention	2016-11-07	<NULL>	<NULL>	1065	Effect of the physiotherapy resources in the distension striaes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UNIFAL-MG - Universidade Federal de Alfenas-MG	UNIFAL-MG - Universidade Federal de Alfenas-MG	https://ensaiosclinicos.gov.br/rg/RBR-4vn75c	<NULL>	15 Female university; aged between 18 and 30 years; white race; presence of distension stretch marks on buttocks; presence of type alba distension stretch marks (white); literate and able to respond to the research questionnaire.	Patients in dermato-functional treatment for improving distension of stretch marks; patients predisposed to keloids; patients with presence of hormonal diseases, cardiac, respiratory, diabetes mellitus, hypertension and cancer; patients unable to provide a sensory feedback or skin sensitivity changes; aversion or allergy to the use of electrical stimulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-7bwvpj	Analyze the behavior of blood pressure in the elderly, After A Execício Session Held in Physical Academy of the Third Age in Rio de Janeiro City	Recruitment completed	Intervention	2016-11-07	<NULL>	<NULL>	1066	Effect of Exercise Held in the Third Age Academies of Rio de Janeiro City (ATI-RJ) About Behavior Blood Pressure in Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-10	Universidade Salgado de Oliveria	Universidade Salgado de Oliveria	https://ensaiosclinicos.gov.br/rg/RBR-7bwvpj	<NULL>	Elderly aged between 60 and 90 years of age, both genders; released by their doctors for physical activity.	No regular physical activity for 2 or more days week within the last two months; smoking habit; cardiac disease well as infarction, coronary arterial disease or stroke within the previous year; chronic kidney disease; bone, muscle or joint limitations precluding exercise performance; use of drugs influencing the autonomic nervous system, particularly beta-blockers; uncontrolled hypertension defined as systolic blood pressure  160 mmHg and or diastolic blood pressure equal to or greater than 105 mmHg at rest.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-7qhkrn	Use of the beta-tricalcium phospate on maxillar sinus floor augumentation	Recruitment completed	Intervention	2016-11-11	<NULL>	<NULL>	1067	Use of the beta-tricalcium phospate on maxillar sinus floor augumentation-a randomized clinical controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia de Araraquara-Unesp	Faculdade de Odontologia de Araraquara-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-7qhkrn	<NULL>	Age between 18-60 years old; presence of the necessity of the sinus floor elevation bilaterally in order to perform the dental implants placement; presence of 5mm or less of alveolar ridge bone; good systemic healthy; absence of non-healed alveolar pos-extraction sites	Smokers or ex-smokers; diabetics; presence of chronic or agressive periodontitis; users of medications which alter the bone metabolism; presence of cronic respiratory infections; Chronic users of antiinflamatory or antibiotics; bruxism; chronic alcohol users; drug users; pregnants; history of radiotherapy at the head and neck region; presence of bone pathologies or disease which affect the bone mtabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-96sw76	Physiotherapy resources in the treatment of localized fat	Recruiting	Intervention	2016-11-16	<NULL>	<NULL>	1068	Electrothermalphototherapy agents in the treatment of the Body Disharmony Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-96sw76	<NULL>	Healthy volunteers; women; aged 18 to 40; sedentary; with the presence of fat located in the abdominal area.	Women in diet; with smoking and drinking habits; women using drugs for weight loss, steroids, progesterone and diuretics; pregnant women; mothers less than one year, women who have electronic monitoring; women with metal implants in the pelvic area; women who are in dermatofuncional treatment on site; surgery and / or radiation therapy for less than 6 months of the abdominal / pelvic area; women suffering from lymphatic system disorders, thrombophlebitis, acute infection, central nervous system diseases, tumors and diabetes, abnormal sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-4n73hw	Association of massage and surface heat treatment on tension-type headache	Recruitment completed	Intervention	2016-11-18	<NULL>	<NULL>	1069	Investigation of association of Manual Therapy and surface heat treatment on Tension-Type Headache	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdades Integradas Einstein de Limeira	Faculdades Integradas Einstein de Limeira	https://ensaiosclinicos.gov.br/rg/RBR-4n73hw	<NULL>	subjects with muscular origin of headaches (tension-type headache); existence of myofascial trigger points.	Subjects with migraine diagnosis; face trauma; systemic rheumatological and oncological diseases; sinusitis; rhinitis; as well as patients in orthodontic treatment; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-494r9r	Comparison of two methods of complete denture fabrication	Recruiting	Intervention	2016-11-18	<NULL>	<NULL>	1070	Traditional versus simplified method for complete denture fabrication in edentulous patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-494r9r	<NULL>	Complete Edentulism (mandible or maxilla) for at least one year; Receptive and mentally agile; Availability to attend evaluations during the study period.	Uncontrolled systemic diseases; Temporomandibular disorders; Surgical Procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-9x4s6y	Comparison of tracheal tubes for tracheal intubation in children undergoing surgery for tonsils removal	Recruitment completed	Intervention	2016-11-18	<NULL>	<NULL>	1071	Comparison of tracheal tube cuffs filled with Air or Alkalinized Lidocaine in patients undergoing Tonsillectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9x4s6y	<NULL>	Children undergoing tonsillectomy or adenoidectomy under general anesthesia; aged between 4 and 12 years; both genders; physical status ASA I or II according to American Society of Anesthesiologists	Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomized for the surgery; the previous presence of stridor or dysphonia; prolonged tracheal intubation required after surgery; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts of tracheal intubation; infection at the surgical site verified during pre-anesthetic evaluation; need of intensive care unit after surgery (severe sleep apnea)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-67xf25	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to extraction of third molars	Recruiting	Intervention	2016-11-21	<NULL>	<NULL>	1072	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to exodontics of third molars	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-30	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-67xf25	<NULL>	exodontia indication of third molar; asymptomatic; positions and similar surgical difficulties; classified as 2B Pell &amp; Gregory (1942)	under 18 years of age patients; patients classified as ASA III or IV; drug use history for pain or anxiety in the 15 days before the beginning of the study; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation; previous history of pericoronitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-3cfcyc	Influence between weight loss and improvement of symptoms in patients with reflux disease to the esophagus (occurs when the stomach contents back to the esophagus)	Recruitment completed	Intervention	2016-11-21	<NULL>	<NULL>	1073	Influence between weight loss and improvement of symtoms in patientes with gastroesophageal reflux disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-25	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-3cfcyc	<NULL>	Both sexes; age over 18 years; BMI greater than 25m ² / kg; that are experiencing typical symptoms (heartburn or regurgitation) 1 x per week or more;presence of diagnosis, confirmed by endoscopy and treatment of GERD; voluntary agreement to participate in the study.	"Hospitalized patients; pregnant / lactating;
patients who underwent surgery of the esophagus and / or stomach; cognitive inability to understand the guidelines;
chronic diseases such as cancer and diabetes mellitus;presence of hiatal hernia;
refractory to drug treatment; presence of complicated GERD with esophagitis grade C or D;
presence of Barrett&apos;s esophagus; patient&apos;s wish to opt for surgical treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-22rh3p	Non-invasive brain stimulation and physical training in stroke patients with motor impairments	Recruiting	Intervention	2016-11-21	<NULL>	<NULL>	1074	Transcranial Direct Current Stimulation and physical training in chronic stroke patients with motor impairments	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-16	Laboratório de Atividade Física e Promoção da Saúde - Instituto de Educação Física e Desportos - Universidade do Estado do Rio de Janeiro	Laboratório de Pesquisas Clinicas e Experimentais em Biologia Vascular	https://ensaiosclinicos.gov.br/rg/RBR-22rh3p	<NULL>	Volunteers of both sexes with hemiparesis, with at least six months of the occurrence of the the stroke; able to wander unsupervised for home march; enrolled in neuromotor rehabilitation program; with score above 36 on the Berg Balance Scale; with a minimum score of 20 on Fulg -Meyer scale; age between 18 to 80.	Patients which having any motor impairment that prevents the tests proposed and / or not controlled co-morbidity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-9jth8n	Effect of passion fruit&apos;s peel flour in the diabetes control	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1075	The effect of passion fruit&apos;s peel flour in glycemic control of people with type diabetes	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Universidade da Integração Internacional da Lusofonia Afro Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-9jth8n	<NULL>	"Being person with type 2 diabetes; between 18 and 65 years old; both sex; no problems in liver or kidney; Not be allergic to passion
fruit."	Being patient with type 1 diabetes; smoker; alcohol drinker; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-94v6kd	Effects of Exercise of the Respiratory Muscles with Different Types of Devices in People with Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2016-11-23	<NULL>	<NULL>	1076	Effects of Respiratory Muscle Training with Different Modalities in Patients with Chronic Obstructive Pulmonary Disease (COPD) - Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal  do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-94v6kd	<NULL>	Follow up with a specialized pulmonology physician, aged between 40 - 80 years, living in city of the study, not in use of oxigenoteraphy or disease exacerbation in the last three months, not practicing regular physical activity in the last six months will be eligible to participate.	Musculoskeletal comorbidities that interfere with the march ; which decreased the oxygen saturation ( SpO2) &lt;90 % during cardiopulmonary exercise testing ; who had difficulty intellectual understanding that prevented them from performing evaluation activities ; abandon the proposed therapeutic program ; missing the proposed activity over one week or they do not appear to the re-evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-9rjg3g	5-fluorouracil 5% compared to vitamin b3 in the treatment of precancerous skin changes	Recruiting	Intervention	2016-11-24	<NULL>	<NULL>	1077	5- fluorouracil 5% intermittent versus nicotinamide at the treatment cancerization skin field: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9rjg3g	<NULL>	Age above 18 years of both sexes; provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm bilaterally.	Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms; current and previous clinical diagnosis or evidence of any medical condition that expose the patient to increased risk, interfere with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; use of topical or systemic immunosuppressive substance, oral retinoid, and other local treatments (eg corticosteroids, anti-inflammatories, retinoids); immunocompromised; pregnancy suspected or confirmed; women of childbearing potential not using contraception; women in breastfeeding; coagulation disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-46xf3w	The monitoring by nurses in controlling high blood pressure and preventing complications	Not yet recruiting	Intervention	2016-11-24	<NULL>	<NULL>	1078	Effect of case management on the control of blood pressure levels and Hypertension complications prevention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Programa de Pós Graduação em Enfermagem da Universidade Federal do Paraná	Secretaria Municipal de Saúde do Município de Dois Vizinhos	https://ensaiosclinicos.gov.br/rg/RBR-46xf3w	<NULL>	"Adults both sexes aged 18 to 58 years;
Have high blood pressure;
Living in the city of Two Neighbors, Paraná;
Be registered at the facility where they will be data collection;
Achieve the minimum score on the Mini-Mental State Examination;
Being partially dependent and independent
as the functional scale of instrumental activities of daily living."	"Pregnant women;
People planning to change your address to another coverage area or city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-29s6x3	Physical exercise for hemodialysis patients	Data analysis completed	Intervention	2016-11-29	<NULL>	<NULL>	1079	Physical exercise for hemodialysis patients: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-15	Universidade Federal do triângulo mineiro	Universidade Federal do triângulo mineiro	https://ensaiosclinicos.gov.br/rg/RBR-29s6x3	<NULL>	Aged 18 to 65, hemodialysis for a minimum period of three months; not use anti-inflammatory; to be able to physical exercise and sedentary for a period longer than or equal to 3 months.	The presence of intense physical fatigue; chest pain; dizziness; pallor; syncope; tachycardia; hypotension; lower limb fatigue; weight gain interdialytic greater than 5 kilograms; difficult vascular access or any significant complaints of pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-3fgwc7	Treatment through electrical stimulation and exercises for urinary incontinence	Recruiting	Intervention	2016-11-30	<NULL>	<NULL>	1080	"Pelvic floor training in urinary incontinence comparing techniques
treatment by intravaginal electrical stimulation and kinesiotherapy"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3fgwc7	<NULL>	Women; with urinary incontinence	Patients with severe lung disease; patients with severe heart disease; patients with neurological diseases; patients with oncological diseases; patients using antidepressant medications in general; patients who have pelvic organ prolapse above the second stage by POP-Q classification; pacemaker users; patients who have undergone surgical intervention for correction of urinary incontinence; patients to initiate any kind of physical activity structured and planned, in addition to those provided for in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-4hrqjf	Effect of protein supplementation and physical exercises in the amount of muscle and in the physical function of elderly with low strength	Recruitment completed	Intervention	2016-11-30	<NULL>	<NULL>	1081	Effect of protein supplementation and resistance training on muscle mass and strength and physical function in sarcopenic elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4hrqjf	<NULL>	Older adults, age sixty years or older; sarcopenic, hand grip strength lower than 20 kg for women and lower than 30 kg for man and/or gait speed lower than 0.8 m/s.	Cognitive deficit; illiteracy; immobilism;diagnoses of congestive heart failure, chronic kidney failure, cancer or descompensated diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-2v6ghb	Laser effectiveness in the treatment of local and distant pain in temporomandibular disorder	Recruiting	Intervention	2016-12-01	<NULL>	<NULL>	1082	Effect of low-level laser therapy in nociceptive local and corporal points in temporomandibular disorder: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-20	Faculdade de Odontologia de Ribeirão Preto (FORP) - Universidade de São Paulo	Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP)	https://ensaiosclinicos.gov.br/rg/RBR-2v6ghb	<NULL>	Women&apos;s volunteers; reporting pain in the facial area for at least 03 months; diagnosed with myofascial pain (temporomandibular disorder) according to the criteria of the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD - this diagnosis will be established after an evaluation with the researchers team).	Women&apos;s volunteers who are in any type of treatment for temporomandibular disorder; who have tumor, trauma or head/neck surgery history; previous diagnosis of fibromyalgia and other painful musculoskeletal syndromes (rheumatic diseases, among others); presence of neurological and/or psychiatric disorders; volunteers who use prescription drugs (anxiolytics, antidepressants, and/or anticonvulsants); pregnant women; users of heart pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-25rc6q	Colour durability of Resin Cement Activated by Light and Double-Activated	Recruitment completed	Intervention	2015-04-06	<NULL>	<NULL>	1083	Colour stability of Photoactivated and Dual Resin Cement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-25rc6q	<NULL>	Volunteers of both genres; age between 20 and 45 years; with good general and oral health; absence of orthodontic appliance; absence of posterior crossbite; absence of noncarious cervical lesions; upper second premolars vital and without restorations; upper second premolars with colour homogeneity in relation to adjacente teeth; areas of buccal surface that circumscribe a circle with minimum diameter of 6 mm	Individuals with gingival recession on buccal surface of upper second premolars; dental sensibility to air blast; enamel or dentin defects; tetracycline staining; unilateral or bilateral crossbite; mandibular prognathism; maxillary retrognathism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-26w4cr	Study of Psma radiopharmaceutical for diagnosis of prostate cancer recurrence	Not yet recruiting	Intervention	2016-12-01	<NULL>	<NULL>	1084	Evaluation of HBED-PSMA-Ga68 kits for prostate cancer biochemical recurrence diagnostic	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2017-01-01	MJM Produtos Farmaceuticos e de Radioprotecao Ltda	Real e Benemerita Associação Portuguesa	https://ensaiosclinicos.gov.br/rg/RBR-26w4cr	<NULL>	Volunteer 18 years of age or older submitted to curative treatment of prostate cancer. Prostatectomy and presenting biochemical prostate cancer recurrence. Indicating PSA&gt; 0.2 ng/ml level. Curative radiochemical therapy and presenting biochemical prostate recurrence. Indicating PSA&gt; 2.0 ng/ml. Result of at least one of the following exams. MDP-Tc-99m bone scintigraphy. Nuclear Magnetic Resonance. Computed Tomography, or Positron Emission Tomography with Fluordeoxiglucose-F-18. Being capable of understand and sign the informed consent.	Radiopharmaceutical therapy administered within four weeks or in a smaller time interval than five half-lives of the used agent. Active infection or fever not explained&gt; 38.5 ° C during screening visits or on the day of the examination. Known hypersensitivity to any of the components Ga-68. HBED-CC. PSMA or excipient of PSMAHBED DC-kit. Any other medical or social condition considered by the investigator prone to interfere with the patient&apos;s ability to sign the consent cooperate and participate in the study or interfere with the interpretation of the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4twh4m	Impact of toothbrushing in the prevention of pneumonia in Intensive Care Unit - ICU	Data analysis completed	Intervention	2016-12-05	<NULL>	<NULL>	1085	Impact of oral hygiene in the prevention of ventilator-associated pneumonia in Intensive Care Unit: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Federal de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4twh4m	<NULL>	Individuals with age equal or greater than 18 years; submitted to endotracheal intubation; expected to remain on mechanical ventilation for &gt;48 hours; without evidence of pulmonary infection at Intensive Care Unit admission.	Individuals without teeth; suspicion of pneumonia at the time of endotracheal intubation; pregnancy; tracheostomy; chlorhexidine allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-2pxsfg	Hidroterapy for sensory losses treatment in diabetic woman´s foot	Recruitment completed	Intervention	2016-12-06	<NULL>	<NULL>	1086	Whirlpool Therapy Effects on Sensory Losses in Diabetic Woman´s Foot	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-18	Faculdades Integradas Einstein de Limeira	Faculdades Integradas Einstein de Limeira	https://ensaiosclinicos.gov.br/rg/RBR-2pxsfg	<NULL>	Medical diagnosis of type 2 diabetes mellitus; sedentary lifestyle; Aged between 40 and 70 years old; Diabetic Neuropathy	lower extremity wounds; orthopedic or neurological disorders in lower extremities; treatments with sensory influences; male gender; Age below 40 years; Age over 70 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-6p8c6d	Identification of Autism in Adults	Recruitment completed	Observational	2016-12-06	<NULL>	<NULL>	1087	Measuring the Autistic Spectrum Disorder (ASD)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-12-10	Universidade Federal de Uberlândia	Faculdade de Matemática da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6p8c6d	<NULL>	Adults higher 18 years, who have agreed to participate in the study and belonging to one of the following categories: Group1 formed by individuals diagnosed with atipical autism; Group2 individuals of the general population of Uberlândia; Group3 academic of the Universidade Federal de Uberlândia, and Grup4 formed by clevers adults, i.e, individuals approved in first place in a public service.	Individuals with less than 18 years and individuals who were unable to complete the questionnaire for any reason, such as dementia, aphasia or illiteracy were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-76t2gs	Effect of comparison of stretching and muscle release technique on posterior stiffness of shoulder in professional handball athletes	Recruiting	Intervention	2016-12-06	<NULL>	<NULL>	1088	Effect of stretching the comparison and mobilize myofascial technique in posterior shoulder tightness in professionals handebol athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-22	Universidade Federal de São Paulo	Centro de Traumatologia do Esporte - CETE	https://ensaiosclinicos.gov.br/rg/RBR-76t2gs	<NULL>	Inclusion criteria were established most athletes aged; at least two years of practice; reporting pain or not the shoulder; with ADM limitation	Exclusion criteria were established athletes with anatomical abnormalities; recent history (in the past 6 months) of upper limb injuries; subscapular nerve damage and previous shoulder surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-7b9xff	Elderly health of the organization in public health in Montes Claros, Minas Gerais, Brazil	Not yet recruiting	Intervention	2016-12-06	<NULL>	<NULL>	1089	Matricial in elderly health in primary health of Montes Claros, Minas Gerais, Brazil	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Estadual de Montes Claros, Unimontes	Universidade Estadual de Montes Claros, Unimontes	https://ensaiosclinicos.gov.br/rg/RBR-7b9xff	<NULL>	age between 60 and 115 years; elderly enrolled and followed in the Family Health Strategy; both genders.	inability to respond to the evaluation questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-2pxh57	Evaluation of eyes implanted with corneal inlays for correction of presbyopia	Data analysis completed	Intervention	2016-12-06	<NULL>	<NULL>	1090	Evaluation of Presbia for the treatment of presbyopia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-05-01	Universidade Federal de Sao Paulo	PresbiBio	https://ensaiosclinicos.gov.br/rg/RBR-2pxh57	<NULL>	Age between 45 years and 60 years, both gender, uncorrect near visual acuity (UNVA) worse than J4, uncorrect distance visual acuity (UDVA) better than 20/40, corrected near visual acuity (CNVA) and correted disttanve visua acuity(CDVA) better than 20/20, spherical equivalent (SE) refraction for distance ranging between 0.25 diopter (D) and 1.00 D, up to 0,75 D of astigmatism, full-time reading glasses for near visual tasks required for a minimum of 1 year, clearly determined ocular dominance, central corneal thickness (CCT) greater than 500 micra, mesopic pupilary diameter more than 3mm and endothelial cell count 2000 cells/mm2 in the eye to be implanted	Anterior and posterior segment pathology, including cataracts in the eye to be implanted, previous intraocular or corneal surgery including cataract and LASIK surgery, chronic systemic or topical corticosteroids, or other immunosuppressive therapy that may affect wound healing, and any immuno-compromised subjects, systemic medications with significant ocular side effects and subjects who use telescopes or microscopes for professional reasons, or have high vision requirements or expectations like surgeons, architects, accountants, professional athletes or pilots.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-7q7pz7	Influence of the day period in which exercise training is performed on cardiovascular function and sleep patterns in hypertensive subjects	Recruitment completed	Intervention	2016-12-06	<NULL>	<NULL>	1091	Time of day influence on cardiovascular and sleep adaptations promoted by aerobic training in hypertensives	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratóio de Rins e Hormônios da Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7q7pz7	<NULL>	men; aged between 30 and 65 years; hypertensives receiving anti-hypertensive drugs for 4 or more months; neither receiving beta-blockers nor non-dihydropyridine calcium channel blockers; neither chronotype type; inactive or insufficiently active; available to participate in the interventions at both proposed times of day (morning and evening).	Presence of cardiovascular diseases beyond hypertesion; presence of osteomioarticular problems that unavaiable to pratice exercise; systolic and diastolic blood pressures higher than 160 and 105 mmHg, respectively; obesity level 2 or above; presence of diabetes with complications or receiving insulin; presence of organ-target damage; presence of complex arrhythmias and/or ischemia during exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-8hfqsm	Screening of patients with hypercholesterolemia  caused by family origin: development of a method for identifying genetic mutations that cause the disease and association between genetic and clinical characteristics of patients	Recruiting	Observational	2016-12-07	<NULL>	<NULL>	1092	Cascade screening of familial hypercholesterolemia from the development of a genotyping method and association of patients genotype and phenotype	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-23	Edson Luiz da Silva	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8hfqsm	<NULL>	Individuals with concentration of low density lipoprotein cholesterol above 160 mg / dL, and their relatives first, second and third degrees. Both genders.	Not include exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-4mxb77	Effects of Body Awareness Therapy in heart rate variability of university students	Recruitment completed	Intervention	2016-12-07	<NULL>	<NULL>	1093	Body Awareness Therapy in heart rate variability of university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-23	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-4mxb77	<NULL>	Healthy volunteers; both genders; aged 18-25 years; higher education students	Smokers; presence of renal; cardiovascular and / or respiratory disease; make use of drugs that influence the autonomic activity of the heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-87xznb	Physiological effects of passive mobilization in critically ill patients admitted to the ICU	Recruitment completed	Intervention	2016-12-07	<NULL>	<NULL>	1094	Hemodynamic effects, serum lactate levels and oxygen content of Passive Mobilization of lower limbs in patients under mechanical ventilation admitted to the Intensive Care Unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-22	Sociedade Pelotense de Assistência e Cultura(SPAC)	Hospital Universitário São Francisco de Paula	https://ensaiosclinicos.gov.br/rg/RBR-87xznb	<NULL>	ICU patients; 18 years of age or over; both genders; under mechanical ventilation; with a degree of sedation equal to or greater than 4, measured by Ramsay scale; with central venous access (CVA); with prescription of motor physical therapy.	Patients with arterial access in the lower limbs; Grade 3 or 4 hypertonia, according to the Ashworth scale; Polytrauma or fractures not consolidated in the lower limbs; Patients in shock or infusion of high doses of vasoactive drugs; Patients with contraindication to bed elevation at 30 degrees or who did not tolerate the supine position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-45zj7b	Massage effect on specific points of the feet on the skin of people presenting risk of injury	Recruitment completed	Intervention	2016-08-08	<NULL>	<NULL>	1095	Effect of foot reflexology on the tissue integrity of feet of people with &quot;Integrity Risk of Impaired Skin&quot;: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-04	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-45zj7b	<NULL>	"It is accompanied by the endocrinology service data collection site.
Of age or above 18 years.
Present the diagnosis of diabetes mellitus for at least five years.
Presenting the nursing diagnosis Skin Integrity Risk Impaired."	"Presence of thrombosis in the lower limbs.
Presence of amputation of the lower limbs.
Presence of open wound on his feet.
Presence of skin breakdown feet.
Presence of foot deformity.
Presence of fractures in the feet.
Presence of sprained foot.
Presence of trauma in the feet.
Presence of recent surgery on his feet."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4x92fr	Evaluation of serum Vitamin D levels in patients with Polycystic kidney disease.	Data analysis completed	Intervention	2016-12-08	<NULL>	<NULL>	1096	Serum vitamin D levels in Autosomal Dominant Polycystic Kidney Disease (ADPKD)patients.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4x92fr	<NULL>	Volunteeers with Autosomal Dominant Polycystic Kidney Disease; both genders; aged between 18 to 75 years; normo or hypertensives; vitamin D deficient [25(OH) &lt; 30ng/ml).	Age &lt; 18 years old; serum calcium &gt; 10 mg/dL; serum phosphorous &gt; 5,5 mg/dL; pregnancy; bowel disease; malignances; current/past use of vitamin D or calcium supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-7w6qb8	Effects of physical exercise and the use of nutritional supplement on overweight, hypertension and diabetes	Recruitment completed	Intervention	2016-12-08	<NULL>	<NULL>	1097	Metabolic syndrome: prevalence and effects of exercise and nutritional supplementation in adults and the elderly of the city of Santo Antônio de Goiás	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-08	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7w6qb8	<NULL>	Volunteers with waist circumference greater than 80 cm; female; age between 20 and 69 years; away gestational period and no allergy to colorants.	Volunteers with waist circumference less than 80 cm; male; the age of 20 and more than 69 years; pregnant women and allergic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-555htm	Remifentanila influence on management control in intravenous Anesthesia.	Recruitment completed	Intervention	2016-12-12	<NULL>	<NULL>	1098	Remifentanila influence on Hypnosis management in Total Intravenous Anesthesia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Centro Médico de Campinas	Centro Médico de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-555htm	<NULL>	They will be included in this study patients enrolled in the pre-anesthetic evaluation office of Campinas Medical Center Foundation; with surgical risk level 1 and 2 (which are lower risk); aged between 18 and 65 years.	illicit drugs and  allergies to any medication used in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-8drccq	Art treatment as a option to restorative approach to Molar Incisor Hypominerlisation	Recruitment completed	Intervention	2016-12-12	<NULL>	<NULL>	1099	Art treatment as a option to restorative approach to Molar Incisor Hypominerlisation	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8drccq	<NULL>	Parents assignature (TCLE); children with good health conditions; children with MIH molar and incisor teeth with dentin breakdown by caries, no pulp involvement.	Children no cooperation during the treatment; children with no good health conditions; when parentes did not sign the TCLE; children teeth that needs extraction or endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-6ct969	Developmental assessment and stimulation of children at risk	Recruitment completed	Intervention	2016-12-14	<NULL>	<NULL>	1100	Assessment of child development and early intervention in high-risk children and their families in Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Universidade Federal de Minas Gerais/Prof. Claudia Regina Lindgren Alves	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-6ct969	<NULL>	They will be admitted newborns included in the House of the Hospital Sofia Feldman baby during the period of conducting the survey; which remained for at least three days in the House of Baby; whose families are willing to participate in the stages of this project and signed the term of free and informed consent.	Children whose parents did not sign the consent form and clear;  whose mothers died at birth;  whose mothers have mental disorders that compromise their understanding or following your child;  with diagnosed sensory disabilities;  with malformation of the nervous system or the locomotor system;  neurogenic diseases or chromosomal disorders diagnosed,  the presence of hypoxic-ischemic lesions (multicystic encephalomalacia or periventricular leukomalacia) diagnosed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-6mpf4v	Evaluation of the macula by optical tomography through surgical mycoscope in patients with media opacities	Not yet recruiting	Observational	2016-12-16	<NULL>	<NULL>	1101	Evaluation by Optical Coherence Tomography Intraoperative through Rescan 700 coupled to OPMI Lumera 700 in patients with opaque media.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Brasileiro de Oftalmologia	Instituto Brasileiro de Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-6mpf4v	<NULL>	Patients with patients with vitreous hemorrhage or cataract ;patients with vitreous hemorrhage without clinical improvement in 60 days when it was not possible to obtain images with OCT preoperatively;  patients with  associatedl vítreoretinal disease the presence of cataract indication of combined surgery ( cataract surgery and vitrectomy ) without preoperative OCT	Absence of posterior vitrectomy indication pars plana ;the presence of preoperative OCT in the last three months before surgery ;failure to obtain the images in the perioperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-48mvdx	The effect of toothpaste with active oxygen  in reducing of dental plaque.	Recruiting	Intervention	2016-12-16	<NULL>	<NULL>	1102	The effect of active oxygen on dental dentifrice in reducing supragingival biofilm:  randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2016-06-16	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-48mvdx	<NULL>	Healthy volunteers; aged between 18 and 35 years; a minimum of 28 teeth; no dental cavities; no  periodontitis and  established gingivitis.	antibiotic therapy three months before the study, using braces, motor difficulty, smoking and lack of commitment to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2s9xvn	Study of methotrexate for the control of chronic inflammation in sickle cell disease patients	Data analysis completed	Intervention	2016-12-19	<NULL>	<NULL>	1103	Pilot study of targeted-therapy with methotrexate for the control of chronic inflammation in sickle cell disease patients	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-12-01	Centro Infantil Boldrini	Centro Infantil Boldrini	https://ensaiosclinicos.gov.br/rg/RBR-2s9xvn	<NULL>	Patients with sickle cell disease who are under chronic hydroxyurea treatment, have more than 3 vaso-occlusive crises per year, and who experience a current vaso-occlusive crisis that is refractory to opioids for a period longer than 3 weeks. Patients should be older than 18 years. Patients must have signed the Informed Consent Form.	Pregnancy. Ongoing infection at recruitment into the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2kwqfx	Effects of aquatic physical therapy on pain and sleep in preterm newborns admitted to a neonatal intensive care unit	Recruitment completed	Intervention	2016-12-19	<NULL>	<NULL>	1104	Effects of aquatic physical therapy on pain and sleep and wakefulness in patients admitted to a neonatal intensive care unit: a quasi-experimental clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2kwqfx	<NULL>	Preterm newborns; Corrected gestational age of 30 to 37 weeks; Clinically stable; Signed by the parents or guardians at the end of free and informed consent.	Patients using invasive mechanical ventilation; Patients on noninvasive mechanical ventilation; Clinically unstable; With recent surgeries; Central and / or peripheral venipuncture in places that prevent immersion in water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-45c8br	Study of the effects of manual lymphatic drainage in water and electrolytic mobilization and heart rate alteration in women in the reproductive and climacteric phases compared to the same parameters in men	Recruiting	Intervention	2016-12-19	<NULL>	<NULL>	1105	Study of the efficacy of manual lymphatic drainage in hidroelectrolytic mobilization and heart rate variability in women in the reproductive and climacteric phases compared to the same parameters in men	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Instituto de Biologia Unicamp	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-45c8br	<NULL>	ormotensos; Eutrophic (normal weight); Not having cardiovascular or respiratory system anomalies; Of endocrine diseases; Non-smoking and non-alcoholic; For perimenopause population may be included voluntary overweight; Self-declared healthy; For the young age group of 18-30 years; Perimenopause age range of 40-50 years.	Presence of acute infections and inflammations; phlebitis; thromboses or thrombophlebitis; hyperthyroidism; cardiopathies; chronic renal diseases; metaplasias and immune disorders; hypersensitivity of the carotid sinus; Use of diuretic medications; antidepressants; anxiolytics or any other medicinal treatments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-249t3r	Pilates effects in pregnant women	Data analysis completed	Intervention	2016-12-20	<NULL>	<NULL>	1106	Effects of Physical therapy through Pilates on the health of pregnant women and newborns	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-13	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-249t3r	<NULL>	Were considered as inclusion criteria:  gilts; aged over 18 years ; the absence of gestational complications described by the medical follow-up.	Exclusion criteria will be considered: multiple pregnancy; presence of chronic low back pain and / or urinary incontinence prior; inability to perform physical exercises by the presence of neurological or musculoskeletal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-3jtxjs	Assessment pityriasis versicolor´s treatmenmt comparing Ketoconazol 2 % cream with Benzoyl Peroxide cream 5% isolateds and with these two together in cream	Recruiting	Intervention	2015-09-27	<NULL>	<NULL>	1107	Randomized double blind clinical trial to compare Ketoconazol 2 % with Benzoyl Peroxide 5% isolatedly and one of  them isolatedly with both together in Pityriasis Versicolor treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Pernambuco	Tárcio dos Santos Pereira	https://ensaiosclinicos.gov.br/rg/RBR-3jtxjs	<NULL>	Voluntary, mael or femael; age 18 years old or more who has clinical  of pityriasis versicolor and agree to take part in the study by consent information term	Patients who referring positive HI;, diabetic; pregnant; patient who taken immunossupressor&apos;s drugs; patients with allergic history to any drugs of the study; patients that have antimycotic in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4n26tf	Evaluation of the Use of Guaco Syrup for Dilation and Reduction of Inflammation in the Respiratory Tract Through Pulmonary Function Tests in Asthmatic Volunteers	Recruiting	Intervention	2016-12-20	<NULL>	<NULL>	1108	Evaluation of bronchodilator and anti-inflammatory activity of guaco syrup in humans by pulmonary function tests in asthmatics volunteers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade federal do paraná	Hospital de clínicas da universidade federal do paraná	https://ensaiosclinicos.gov.br/rg/RBR-4n26tf	<NULL>	Moderate persistent asthm (according to the classification criteria included in the IV Brazilian Guidelines for Asthma Management); aged between 18 and 60 years; diagnosis of asthma performed by spirometry (FEV1 / FVC &lt;90%, with FEV1 being forced expiratory volume in 1 second and FVC functional vital capacity).	Volunteers who had a stroke or acute myocardial infarction in the last three months; aortic aneurysm; systolic blood pressure higher than 200 mmHg or diastolic blood pressure higher than 90 mmHg; epileptics; unable to understand the procedure and implications of the study; with induced bronchoconstriction by recent spirometry; recent airway infection (during the last six weeks); during or near an asthma exacerbation; pregnant or breastfeeding women; in use of cholinesterase inhibitors; and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2hx7p2	Comparison of the effects of two anesthetic protocols on the glycemic levels of patients undergoing extraction.	Recruiting	Intervention	2016-12-21	<NULL>	<NULL>	1109	Comparison of the effects of 2% lidocaine solutions with adrenaline 1: 100,000 and prilocaine 3% with felipressin 0.054 iu / ml in concentrations of blood glucose during exodontia.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-26	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2hx7p2	<NULL>	Patients older than 18 who will sign the TCLE; Medication-controlled diabetes mellitus; Patients in need of a simple exodontia in the mandible region using as an anesthetic technique the blockage of the inferior and buccal alveolar nerve; Surgical difficulties similar.	Patients under 18 years of age; Any general health problems, based on medical history and physical examination;History of use of any type of medicine in the 15 days prior to the beginning of the research;History of hypersensitivity to drugs, substances or materials used in this experiment;Pregnancy or lactation;Anatomical location of the tooth unfavorable to the inferior alveolar and buccal nerve block.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-89cp93	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients.	Data analysis completed	Intervention	2016-12-22	<NULL>	<NULL>	1110	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89cp93	<NULL>	Patients of both sexes, aged between 18 and 100 years old, admitted to the ICU of the study, if they had a expected time of hospitalization exceeding 48 hours.	Pregnancy, blood dyscrasia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-66jx7j	Metabolic, inflammatory, genetic and satiety response to consumption of monounsaturated fatty acids and fructose	Recruitment completed	Intervention	2016-12-26	<NULL>	<NULL>	1111	Metabolic, inflammatory, genetic and satiety response to consumption of monounsaturated fatty acids and fructose	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-66jx7j	<NULL>	Healthy volunteers; female; non-smoker; aged 20-40 years; normal weight (BMI between 18.5-24.9 kg / m 2) or overweight / obesity class I (BMI 25.0 to 35.0 kg / m2); stable weight in the last three months (less than 5% of usual weight).	Pregnancy; lactiontion; or menopause; infections or inflammation in the experiment days; inflammatory, heart, liver, renal, gastrointestinal and respiratory diseases; hormonal treatment or prescribed drug that affect the digestion and absorption of nutrients; in use of hormones or drugs that affect energy, glucose or lipid metabolism; smoker; history of abuse of alcohol or drugs; unstable weight in the last three months (higher than 5% of usual weight); athlete.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4qxgjh	Polycystic Ovary Syndrome and Physical Exercise	Recruitment completed	Intervention	2016-12-26	<NULL>	<NULL>	1112	Cardiovascular Risk in Polycystic Ovary Syndrome: Effect of Different Physical Exercise Programs on the Hormonal, Cardiovascular, Metabolic, Reproductive and Quality of Life Aspects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-11	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes – HUOL-UFRN	https://ensaiosclinicos.gov.br/rg/RBR-4qxgjh	<NULL>	Diagnosis of polycystic ovary syndrome according to the Rotterdam criteria	Other disorders such as nonclassic congenital adrenal hyperplasia, thyroid dysfunction, and hyperprolactinemia; renal or hepatic dysfunction; or use of medications known to affect reproductive, cardiovascular or metabolic function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-8d2s62	Analysis of the results obtained in the post-operative surgery where an implant replaces the knee joint	Recruiting	Intervention	2015-09-02	<NULL>	<NULL>	1113	Clinical analysis of new knee prothesis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-12	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	https://ensaiosclinicos.gov.br/rg/RBR-8d2s62	<NULL>	Healthy participants; both sexes;  60 to 70 aged years; with a diagnosis of osteoarthritis of grade IV and V according to Ahlback classification modified by Keyes; not have performed arthroplasty knee surgery earlier; failure of nonsurgical treatment (medication or physical therapy); not psychiatric disorders; not have diseases that have bone loss; not have chronic diseases including rheumatic diseases; not an alcoholic.	Participants with serious injuries in the operated knee; have deep infection; deep vein thrombosis without control with medical treatment; leaving treatment or follow-up; participant who no longer wish to perform the stipulated protocol; participant&apos;s death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-5n95rm	Evaluation of an educational program for the home care of patients undergoing prostate surgery	Recruitment completed	Intervention	2016-12-27	<NULL>	<NULL>	1114	Analysis of a teaching program for the preparation for discharge of patients undergoing radical prostatectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Fundação hospitalar Geraldo Corrêa	https://ensaiosclinicos.gov.br/rg/RBR-5n95rm	<NULL>	Age over 18 years; have cognitive ability for participation assessed from the application of mini mental state examination; refer locomotor ability, visual, hearing and realization of self-care; have a telephone (fixed or mobile) to continue the education program.	Patients report difficulties to receive phone calls were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-6dk3y3	Effect of interferential current combined with exercise in patients with fibromyalgia: randomized clinical trial	Recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1115	Effect of interferential current combined with exercise on fibromyalgia: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6dk3y3	<NULL>	Patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of interferential current, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-26pms3	Rehabilitation in chronic obstructive pulmonary disease	Recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1116	Rehabilitation in chronic obstructive pulmonary disease - functional, cognitive and epigenetic aspects	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-26pms3	<NULL>	Patients with moderate to very severe chronic obstructive pulmonary disease;  of both genders; presenting clinical stability in the month prior to the beginning of the protocol and aged 40 years or more.	Current smoking; associated diseases that preclude the achievement of some of the evaluations of the study or that limit the progression of training, such as orthopedic, neurological and heart disease; and not signed the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-8xkwyp	Effects of exercise using video game and nutritional guidance on musculoskeletal function in older women	Recruitment completed	Intervention	2016-02-18	<NULL>	<NULL>	1117	Effects of video game physical training and nutritional orientation on functional capacity of older women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-08	Uiniversidade Federal do Paraná - UFPR	Instituto Federal do Paraná - IFPR	https://ensaiosclinicos.gov.br/rg/RBR-8xkwyp	<NULL>	Independent older women, 65 years and over; residents in the Curitiba city and metropolitan area, Parana, Brazil; inactive or moderately active; without cognitive impairment according to the Mini mental state examination	Volunteers with diagnosis of neurological disease and/or trauma and orthopedic fixation or prosthesis with metallic or non-metallic implants, cardiac, respiratory, kidney, liver, osteoporosis, diabetes, hypertension and endocrine decompensated; obese; use of medications that affect balance; visually impaired without the use of visual correctors; voluntary unavailable to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-4qyc94	Effects of intensity exercises in functional capacity in older woman	Recruitment completed	Intervention	2016-12-27	<NULL>	<NULL>	1118	Effect of High Intensity Interval Training protocol in functional capacity in older woman of Rio Pomba city - MG: A randomized controlled triall	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Instituto Federal do Sudeste de Minas	Secretaria de Saúde da cidade de Rio Pomba	https://ensaiosclinicos.gov.br/rg/RBR-4qyc94	<NULL>	Age greater than 65 years; group of practitioners Exercise and Wellness for more than three months; agreement to participate in the study and signed the free and informed consent	HIV patients; poorly controlled hypertension (SBP: 165 mmHg and / or DBP: 100 mmHg); decompensated diabetes (random blood glucose: 200 mg / dL); severe heart disease; severe neurological disorders; neuromuscular and musculoskeletal disorders incapacitating to perform the experimental protocol; neoplasms; patient unable to understand the objectives of the study and / or informed consent. There will also be excluded from the protocol those who submit, twice in succession or three times alternating, pressure values and / or glucose, above the pre-set values (criteria not included) during the training protocol and those missing protocol more than three times alternating or consecutive.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-753kcg	The effect of the operating group for care teaching with their feet to prevent risk of injuries on the feet of people with Diabetes.	Not yet recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1119	The effect of the operating group for care teaching with your feet in the prevention of skin integrity impaired risk of the feet of people with diabetes mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-753kcg	<NULL>	People of both sexes with Diabetes Mellitus Type II diagnosed for at least five years; be registered in the Family Health Unit ; have the age of eighteen.	People of both sexes, with Type 1 Diabetes Mellitus; Presence of ulcers in the feet; Presence of amputations in the lower limbs; Presence of thrombosis; Deficit in cognitive ability defined by the Mini Mental State Examination (MEEM).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-6k3rqh	Effectiveness of auriculotherapy in pain of persons with cancer in chemotherapy	Recruitment completed	Intervention	2016-05-05	<NULL>	<NULL>	1120	Effectiveness of auriculotherapy in pain of persons with cancer in chemotherapy: a clinical tria.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-23	Universidade Federal de Alfenas	Clicia Valim Cortes Gradim	https://ensaiosclinicos.gov.br/rg/RBR-6k3rqh	<NULL>	Inclusion criteria will be considered: being in chemotherapy treatment and mentally oriented; Presenting pain greater than or equal to four in the Numerical Pain Scale; Be accompanied by the oncology sector (UNACON) and / or the Dor Hospital Clinic; Accept needle treatment and present age equal to or greater than 18 years.	As exclusion criteria, the presence of conditions that would contraindicate the insertion of needles at auriculotherapy sites (lesions, edema, absence of the auricular pavilion, among others) will be considered; Allergy to micropore; Terminal patient and / or with cancer of the head and neck and people who use anticoagulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-5x8ttb	Caffeine supplementation can make runners run further and improve pace strategy	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	1121	Effects of creatine and caffeine supplementation association in street runners performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-21	Erico Chagas Caperuto	Elias de França	https://ensaiosclinicos.gov.br/rg/RBR-5x8ttb	<NULL>	Healthy participants which did not use any ergogenic supplements in the last 6 months preceding the test.	Individuals without previous experience in running on the treadmill; intolerant individuals to caffeine use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3dmsbk	Feet reflex massage in older womem	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	1122	Effects of podal reflexology massage in older womem	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Instituto Federal do Paraná - IFPR	Instituto Federal do Paraná - IFPR	https://ensaiosclinicos.gov.br/rg/RBR-3dmsbk	<NULL>	Independent older women, 60 years and over; residents in the Curitiba city and metropolitan area, Parana, Brazil; without cognitive impairment according to the Mini mental state examination	Volunteers with diagnosis of the following disease: neurological, trauma-orthopedic, cardiac, respiratory, kidney, liver, osteoporosis, decompensated diabetes, decompensated endocrine and arterial hypertension; and voluntary unavailable to participate in any stages of the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3fvm6v	Effects of the association of the use of cholesterol-lowering medication and regular practice of physical exercise in people infected with HIV	Not yet recruiting	Intervention	2016-12-28	<NULL>	<NULL>	1123	Association betwwen statin and regular physical activity in people infected by HIV: randomized clinical trial, double-blind and placebo-controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3fvm6v	<NULL>	Being HIV-infected and using antiretroviral therapy for more than a year and being dyslipidemic. Be over 18 years and less than 60. Have health conditions for the practice of the proposed physical exercises. Be sedentary. Have trip availability three times a week to the training location.	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-5wddpz	Evaluation of the use of laser for treatment in children&apos;s deep caries.	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1124	Use of antimicrobial Photodynamic Therapy as an adjunct in reducing microorganisms of the oral cavity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Faculdade de Odontologia - Universidade Federal Fluminense	Faculdade de Odontologia - Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5wddpz	<NULL>	Children between 3 and 12 years of age with primary or permanent molars having active  deep caries lesion and without pulp involvement	Children whose guardians refused to sign the informed consent document; children who do not cooperate with the clinical examination; with syndromes or chronic systemic diseases; teeth with painful symptoms consistent with irreversible pulpitis or mobility; periodontal changes; roots with pathological resorption; cases of primary teeth roots in advanced stage of physiological resorption and patients who have made use of any antibiotics during the study period or within three months before its initiation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-6zmz3c	Influence of subjective wellbeing in decision making	Recruitment completed	Intervention	2016-12-29	<NULL>	<NULL>	1125	Influence of subjective wellbeing in decision making: an electrophysiological study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6zmz3c	<NULL>	"Medical students of the Federal University of Pernambuco
attending a course called Personal and Professional Development"	Participate in less than 75% of the sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-52mr7h	Individual nutritional follow-up in cardiopulmonary and metabolic rehabilitation program improves diet quality and reduces abdominal circunference: randomized clinical trial	Recruitment completed	Intervention	2016-12-29	<NULL>	<NULL>	1126	Nutritional Follow-up in cardiopulmonary and metabolic rehabilitation program: randomized clinical trial in a specialized service	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-30	Instituto de Cardiologia do Rio Grande do Sul	Centro Integrado de Medicina do Exercício	https://ensaiosclinicos.gov.br/rg/RBR-52mr7h	<NULL>	Being 35 years of age or more, integrate cardiopulmonary and metabolic rehabilitation program	Being 35 years of age or less, living in nutritional monitoring or under use of medication for weight loss, present plasma triglycerides greater than 500 mg/dl, have frequency of less than 75% in the appointments, or do not attend the initial / final evaluations and, recurrence of Acute myocardial infarction, stroke or other event that causes their withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-2hp7rs	Evaluation of blood return and varicose veins in the lower limbs of pregnant women users and non-users of elastic stockings	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1127	Evaluation of venous reflux and varicose veins in lower limbs of pregnant women: comparison between users and non-users of compression stockings	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Estadual Paulista - Faculdade de Medicina de Botucatu	Universidade Estadual Paulista - Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-2hp7rs	<NULL>	pregnant women who are between the 10th to 15th week of gestation; over 18 years old; not suffering from arterial disease, lymphatic or orthopedic.	patients overweight or obese; patients with edema of the lower limbs caused by other reasons than venous;  with CEAP classification above 3; carrier of recent or old DVT.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-3nxn34	Reproducibility of blood pressure reduction and its physiological regulators after a sessions of  exercise executed in different days	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1128	Reproducibility of post-exercise hypotension and its hemodynamic and autonomic mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3nxn34	<NULL>	"Both genders
Age between 20 and 60 years
Blood pressure levels below 160/105 mmHg
Absence of cardiovascular disease
No use of medications that block the autonomic nervous system
Absence of orthopedic problems that contraindicates physical exercise"	Presence of complex arrhythmias and/or ischemia during a cardiopulmonary exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6rp3ds	Clinical evaluation of previous use of local anesthetic anti-inflammatories in pain control after canal treatment;	Recruitment completed	Intervention	2016-12-29	<NULL>	<NULL>	1129	Evaluation of premedication with anti-inflammatory and anesthetic solution in the control of post-endodontic pain;	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6rp3ds	<NULL>	Healthy volunteers; both genders; age between 18 and 60 years; signed consent form; endodontic treatment needs; symptomatic; ability to understand the pain scales and questionnaires.	Use of analgesics or anti-inflammatories drugs within 12 hours before the endodontic procedure; acute dento-alveolar or periodontal abscess; needs of antibiotic prophylaxis; pregnant or lactating; mental disability; systemic alterations or allergies that contraindicate the use of the anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-4q5wsz	&quot;Effect of a muscle strengthening program in neural functions and in emotional state of elderly with mild cognitive impairment&quot;	Recruitment completed	Intervention	2017-01-02	<NULL>	<NULL>	1130	&quot;Effect of a home-based muscle strengthening program on cognitive function and affective state of community-dwelling elderly with mild cognitive impairment&quot;	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4q5wsz	<NULL>	Older adults with 60 years or more; community-dwelling residents; able to walk with and without ai; mild cognitive impairment.	Illiteracy; visual and/or auditory deficit; descompensated clinical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6s6p7s	Use of resting net in preterm infants who are in incubators in the Intensive Care Unit	Recruiting	Intervention	2017-01-03	<NULL>	<NULL>	1131	The use of therapeutic network in incubators used by Newborns in the Neonatal Unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Mato Grosso do Sul - UFMS	Hospital Regional de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6s6p7s	<NULL>	Newborns independent of sex; Hemodynamically stable; More than 72 hours of life; Spontaneous breathing; Without congenital malformations, without neurological disorders; Minimum weight of 700 grams.	Do not meet the criteria eligible for the study; Not complete the time required for the completion of the research; Peri-intraventricular haemorrhage grade III or IV; Use of supplemental oxygen therapy; FC less than 20 bpm than the initial measurement; Signs suggestive of increased respiratory work.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-9wdkjh	Evaluation of patients with Sleep Apnea and difficulty in use continuous positive airway pressure device (CPAP) through endoscopy of upper airways under sedation	Recruitment completed	Intervention	2017-01-03	<NULL>	<NULL>	1132	Evaluation of Obstructive Sleep Apnea  patients with difficulty of CPAP adaptation through Drug-induced Sleep Endoscopy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9wdkjh	<NULL>	Obstructive sleep apnea syndrome; both genres; age &gt; 18 years; IMC &lt; 40 Kg/m2; suffocation related to the CPAP usage. Patients with no complaints related to CPAP usage were recruited as control group.	age &lt; 18 years; IMC &gt; 40 Kg/m2; medical conditions that contraindicated the exam	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-3p4npx	Reduction assessment of cold or flu symptoms with Fluviral® compared to Resfenol®, in  adult participants	Not yet recruiting	Intervention	2017-01-04	<NULL>	<NULL>	1133	Prospective, multicenter, parallel, single-blinded, randomized, non-inferiority clinical study to evaluate the reduction of cold or flu symptoms with Fluviral® compared to Resfenol®, in  adult participants	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-03-01	Hospital das Clínicas de Porto Alegre	Scentryphar	https://ensaiosclinicos.gov.br/rg/RBR-3p4npx	<NULL>	Adults; Both genders; Age between 18 and 60; Patients diagnosed with flu or cold with congestive and exudative symptoms such as corizas, muscle aches, fever, headache, nasal congestion and other symptoms present in Influenza like illness; Women of childbearing potential should be sexually inactive or be using one of the acceptable methods of contraception; Women without childbearing potential must be surgically sterile or already have over 2 years post-menopause.	History of hypersensitivity to the components of the study formulations; history of alcohol or drug abuse; bronchial asthma, severe kidney or liver disease, high blood pressure, heart disease, diabetes, thyroid dysfunction, glaucoma or prostatic hypertrophy; history of asthma maintenance therapy and/or asthma attacks in the last 5 years; clinical evidence of immunosuppression; use of monoamine oxidase inhibitor medicines (eg .: phenelzine, iproniazid, isocarboxazid, harmaline, nialamide, pargyline, selegiline, toloxatone, tranylcypromine, moclobemide); surgery or dental intervention with general or spinal anesthesia; be vaccinated against the flu less than 1 week prior to study enrollment; use of tricyclic antidepressants (amitriptyline, clomipramine, imipramine), barbiturates or oral anticoagulants; pregnant or nursing women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-4b7gmb	Comparison of physical fitness and the morbidly obese oxygen consumption during different cardiopulmonary test protocols on treadmill and stationary bike	Recruiting	Observational	2017-01-06	<NULL>	<NULL>	1134	Comparison of cardiopulmonary and metabolic performance and CLVO2 analysis in obese patients during cardiopulmonary stress tests on treadmill and bicycle: incremental protocol x constant load	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-03-08	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-4b7gmb	<NULL>	The study included female subjects (since obesity waiting list is formed for the most part by women and so there is no contamination of data and bias due to low number of male patients) with: Sheet physical therapy preoperative evaluation completed; subjects with obesity class II and III, have BMI&gt; 35 and &lt;60 kg / m2); the age and / or equal to 18 and less than and / or equal to 59 years; Sedentary individuals or assets; no deficit in the locomotor system and / or balance disorders reported or detected on physical examination without changes in heart function (released by cardiologist by certified to perform physical exercise), and acceptance and signing of the informed consent and informed .	The exclusion was determined when the subjects did not properly perform the ventilatory evidence presented spirometric function not preserved by FEV1 / FVC &lt;0.70, present musculoskeletal limitations or pain preventing the holding of the test, submit a confirmed diagnosis of some heart disease and asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-9gghtb	Costs and benefits of papachia in pediatric dentistry: A randomized clinical trial	Data analysis completed	Intervention	2017-01-08	<NULL>	<NULL>	1135	Cost evaluation and comparison of the public health benefits of the atraumatic method of caries removal with papayar gel in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade de Cruz Alta	https://ensaiosclinicos.gov.br/rg/RBR-9gghtb	<NULL>	Children of both sexes, enrolled in the 1 year of Municipal Schools of the city of Ijuí of RS state that had carious lesions cavitated in deciduous or permanent molars	Children who did not have restorative needs, or had only dental caries lesions, or that the parents or guardians did not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-8n94qg	Neurofunctional Physical Therapy in Parkinson&apos;s disease: a feasibility trial	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1136	Neurofunctional Physical Therapy in Parkinson&apos;s disease: assessments tools and answer to physiotherapy intervention	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade do Estado de Santa Catarina	University of Miami Miller School of Medicine	https://ensaiosclinicos.gov.br/rg/RBR-8n94qg	<NULL>	Individuals diagnosed with Parkinson&apos;s disease confirmed by the neurologist according to London Brain Bank criteria (Hughes et al., 1992); 50-90 years, mild to moderate staging of disease (stages 1 to 3 according to the Hoehn and Yahr Scale); stable medication (on the same medication / dose for at least 4 weeks); cognitive level related to scholarity level (in Mini Mental State Exam).	Patients presenting other neurological disorders associated; presenting orthopedic pathologies and / or joint limitations that affect the musculoskeletal system and make it difficult and / or difficult to perform the training; individuals who can not perform walking independently.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-5q9svp	Acupuncture evaluation in treatment of pain related to articulation of the chewing region.	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1137	The evaluation of Acupuncture effectiveness in the treatment of chronic pain associated with temporomandibular disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5q9svp	<NULL>	Agree to sign the consent form;Diagnosed with muscular TMD, joint or mixed, according to the criteria of the RDC-TMD;In the age group between 20-65 years;Both sexes;Symptomatic pain for more than six months	"With a rheumatic diseases history affecting the muscles and joints;psychiatric or neurological conditions that complicate the diagnostic process;surgical implants for treatment of TMD;
Blood coagulation disorders;Needle Phobia;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-2gv984	Evaluation of surrogate markers of protection for the evaluation of vaccine strategies against mycobacterial infections in BCG-revaccinated individuals	Recruitment completed	Intervention	2017-01-09	<NULL>	<NULL>	1138	Evaluation of surrogate markers of protection for the evaluation of vaccine strategies against mycobacterial infections in BCG-revaccinated individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Fundação Oswaldo Cruz - Bahia	Fundação de Amparo à Pesquisa da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-2gv984	<NULL>	Healthy volunteers; enrolled in the first year of graduate courses of Medicine, Physiotherapy, Dentistry, Nursing, Phonoaudiology, Nutrition or Pharmacy of two universities; with visible/measurable BCG scar; negative in double testing with PPD RT 23 (2 tuberculin units, 7-10 days of interval between tests).	Positive serology for the human immunodifciency virus (HIV 1/2) using an immunoenzimatic assay (ELISA); HIV test refusal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-75bwry	Tranexamic acid in total hip arthroplasty	Recruitment completed	Intervention	2017-01-09	<NULL>	<NULL>	1139	Tranexamic acid in primary non-cemented total hip arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Instituto Nacional de Traumatologia e Ortopedia	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-75bwry	<NULL>	Primary total hip replacement	Prior surgery same Joint;infecton;congenital coagulopathies carriers acquired;intravascular coagulation Active;acute occlusive vasculopathy;Hypersensitivity components of the formula;chronic use of oral anticoagulants and corticosteroids;allergy background or faced to transfusion plasma;Carriers of chronic diseases;Patients with malignant neoplasias and autoimmune diseases;need for bone grafting;revision surgeries;no concordance with the written informed consent and informed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6c26hx	Oral minoxidil and spironolactone versus topical minoxidil for female pattern hair loss	Not yet recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1140	Oral minoxidil and spironolactone versus topical minoxidil for female pattern hair loss	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade Medicina da Universidade Estadual Paulista - UNESP	Faculdade Medicina da Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6c26hx	<NULL>	Patients with female pattern hair loss; age between 20 and 55 years	Patients who had been treated for hair loss in the last 6 months, patients with hipertension, heart and kidney disease, patients with other causes of hair loss tha female pattern hair loss, patients in childbearing age who not using contraception;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-9b3qqd	Influence of gingival cord retractor in the success rate of restorations near to  gingiva using two different materials.	Not yet recruiting	Intervention	2017-01-10	<NULL>	<NULL>	1141	Influences of gingival cord retractor in retention rate of non-carious cervical lesions restorations with different adhesive systems.   Randomized clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9b3qqd	<NULL>	Healthy volunteers; both genres; presence of at least four non carious cervical lesions of similar dimensions in the same arc and opposite quadrants; good oral hygiene.	Presence of cavities, cracks or enamel fractures; extensive  or unsatisfactory restorations; recent restorations involving the labial surface; dentures or orthodontics; presence of periodontal disease and,or parafunctional habits; systemic disease and, or severe psychological; constant use of analgesic and, or anti-inflammatory or allergic response to dental products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-799724	Women with Temporomandibular dysfunction pain are more responsive to nadolol analgesic effect	Data analysis completed	Intervention	2017-01-10	<NULL>	<NULL>	1142	Effect of nadolol on Temporomandibular pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-799724	<NULL>	Men and women (using or not oral contraceptive), aged between 18 and 48 years and met Research Diagnostic Criteria for TMD (RDC/TMD) class I (muscle pain) and II (articular pain).	"Self-reported osteoarthroses (RDC group IIIc), rheumatoid arthritis, fibromyalgia, trigeminal neuralgia, gynecological disorders (endometriosis), asthma, chronic lung disease, bronchospasm, renal, hepatic or cardiovascular diseases, nasal polyps, angioedema, reactivity to acetylsalicylic acid or other NSAIDs. Irregular menstrual cycles, use of hormonal replacement therapy, pregnancy or nursing, craniofacial trauma or surgery within the last 6 weeks, orthodontic treatment, and depression or other psychiatric conditions, seizures, drug abuse, current chemotherapy or radiation therapy; patients taking the following medications: drugs with central nervous system action (e.g., opioids, benzodiazepines, nonbenzodiazepine sedative hypnotics, selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, and anticonvulsants) and ?-blockers. Medications for headaches (e.g.  triptans) and NSAIDs were not allowed during the last two days before the study visits. 
Subjects with low heart rate (e.g. under 55 bpm) and diastolic blood pressure below 50 mmHg were excluded from the study to reduce the risk of an adverse hypotensive response to ?-blockade."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-8k5yzn	Facial pain treatment in individuals with Fibromyalgia: effect of laser therapy versus anesthetic infiltration.	Data analysis completed	Intervention	2017-01-11	<NULL>	<NULL>	1143	Orofacial pain treatment in individuals with Fibromyalgia: Effect of laser therapy versus anesthetic infiltration of trigger points	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8k5yzn	<NULL>	Patients with fibromyalgia according to the American College of Rheumatology criteria; aged between 18 and 76 years; sufficient autonomy and cognitive levels to understand procedures and follow instructions without help of another person; report of orofacial pain in the last 3 months.	Patients who did not voluntarily participate in this research; allergic to lidocaine; or who have changed their systemic medications in the last 3 months treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-37tjbg	Analysis of the electrical activity of muscles used in gait of paraplegic patients in two different gait training methods using a support of body weight	Data analysis completed	Observational	2017-01-11	<NULL>	<NULL>	1144	Electromyographic analysis of muscles used in gait of patients with spinal cord injury in two different training modalities with body weight suspension	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Fernanda Cechetti	https://ensaiosclinicos.gov.br/rg/RBR-37tjbg	<NULL>	Patients who agree to participate in the study and sign the Informed Consent Term (TCLE), with clinical diagnosis of spinal cord injury, ASIA C or D score, ie, incomplete injury with motor preservation below the neurological level, with Most of the key muscles below that level with less than or equal to three muscle strength, respectively, and are able to remain seated independently in a bed.	Patients who present with weight-bearing contraindications, such as a fracture of the hip or lower limb, or because they have bedsores. Also, patients who present with unstable angina or other decompensated heart disease, chronic obstructive pulmonary disease, neurological diseases such as Parkinson&apos;s or stroke or have a symptomatic drop in blood pressure when upright.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4vpwkg	Effects of carbohydrate mouth rinsing in the physical performance of cyclists	Recruitment completed	Intervention	2017-01-11	<NULL>	<NULL>	1145	Effects of carbohydrate mouth rinsing on physiological variables and physical performance during a cycling test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-15	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4vpwkg	<NULL>	individuals adult; males; aged 18 and 45; report weekly training cycling at least five hours per week.	smokers participants; obese; previously diagnosed with chronic diseases; history of musculoskeletal injuries that interfered with his training routine in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-3gg3mg	Prospective and randomized clinical study of class II restorations using low polymerization resins and conventional composite resin	Recruitment completed	Intervention	2017-01-11	<NULL>	<NULL>	1146	Prospective clinical randomized study of restorations of class II composite resins using low polymerization shrinkage	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-18	Financiamento Próprio	Faculdade de Odontologia da Universidade Estadual Paulista - Campus de Araçatuba ( Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-3gg3mg	<NULL>	Age from 18 years, regardless of gender; good health, no medical history of allergies to dental products and medicines; Presence of at least 3 posterior teeth (pre-molars and / or molars independently of their location in the dental arch) with a need for restoration, of different etiologies (dental caries, need for replacement or replacement of old restorations due to secondary caries, fracture or Aesthetic reasons) involving the occlusal face and at least one proximal face; Presence of teeth that are antagonistic to the study, provided they are not restored with porcelain; Presence of the adjacent tooth in contact with the proximal face to be evaluated by the study. The teeth analyzed in this study should present cavities whose depths are classified as medium or deep, absence of periapical changes or endodontic treatment.	Pregnant or lactating women; Occlusal disorders or temporomandibular joint dysfunction (TMD); Patients who are undergoing continuous treatment and use of analgesics or anti-inflammatory drugs; Continuous use of desensitizing agents or fluorine; Active and untreated periodontal disease; Dental mobility; Use of orthodontic appliances; History of anterior tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-6xwc26	Clinical research in the treatment of the asthma crisis, at emergency room, comparing the ciclesonide &quot;bomb&quot;, in a dose of nine sprays, with hydrocortisone, corticosteroid injected into the vein	Recruitment completed	Intervention	2017-01-12	<NULL>	<NULL>	1147	Efficacy and effectiveness of inhaled Ciclesonide in the treatment of acute Asthma attack: double-blind randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2012-01-24	Universidade Federal de São Paulo-Escola Paulista de Medicina	Universidade Federal de São Paulo-Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-6xwc26	<NULL>	Asthmatic patients aged greater than 13 years, with no upper limit and of both sexes, diagnosed with asthma according to the criteria of the GINA (Global Initiative for Asthma), moderate or severe asthma,that is, with lower FEV1 50 %.	Excluded patients with a body temperature greater than or equal 37,8º; smoking; pregnant women; patients in psychiatric treatment or with a history of heart disease, liver, kidney or other diseases that prevent the use of corticosteroids; patients in the postoperative pulmonary resection in treatment for pulmonary tuberculosis or fungal infection, tracheostomy or mechanical obstruction of the trachea. Patients with myopathy or neurological sequelae (stroke or encephalopathy) that prevent the implementation of the measures necessary for the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-2wkqpw	Hand puncture in relieving pain of the newborn during collection of the foot test	Recruiting	Intervention	2017-01-12	<NULL>	<NULL>	1148	"Venipuncture in hand to relieve newborn pain during the collection of newborn screening: a
randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade de Brasília	Secretaria de estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2wkqpw	<NULL>	Newborns (&lt;28 days), of both genders, independent of gestational age admitted to the hospital unit studied.	Babies with cerebral anatomical abnormality; injury or bone fracture; Apnea history less than 72h; Venous access infiltrates or lost at the time of research; baby who were undergoing painful invasive procedures such as punctures and passing of a nasogastric tube or vesical cathetein less than 1 hour of the study intervention; involvements of the CNS as cerebral hemorrhages, syndromes with neurological impairment, seizure history and hypertension; and also the presence of congenital heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4frygy	Patellar tendon pain: risk identification in athletes	Recruiting	Intervention	2017-01-12	<NULL>	<NULL>	1149	Patellar tendinopathy in sport: risk profile identification and preventive strategies definition.	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Financiamento próprio dos pesquisadores	Financiamento próprio dos pesquisadores	https://ensaiosclinicos.gov.br/rg/RBR-4frygy	<NULL>	Athletes within 15 to 45 years old, both sexes, no history of injuries in last year, no orthopaedic surgery history and with full partcipation in sport team routine.	No show in data collection and/or pain or incapacity during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-56dkrb	knowledge and attitude of women from the Brazilian state of Rio Grande do Sul regarding discovery of breast cancer	Data analysis completed	Intervention	2017-01-13	<NULL>	<NULL>	1150	knowledge and attitude of women from the Brazilian state of Rio Grande do Sul regarding early detection of breast cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-56dkrb	<NULL>	Women over 18 and under 80 years of age;with cognitvas able to perform the reading of educational material ; with conditions to respond to the study questions	Illiterate women; who did not have a position to answer the questions raised by the research, based on age , level of consciousness or difficulty of communication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-6rp2sn	The Importance of Hand Therapy download package in the use of the affected arm out of therapy.	Data analysis completed	Intervention	2017-01-16	<NULL>	<NULL>	1151	The relevance of the Therapy Transfer Package for containment induced in the upper limb of use out of the therapeutic environment.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Hospital e centro de reabilitação da AACD	Hospital e centro de reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-6rp2sn	<NULL>	Diagnostic Chronic stroke (above 6 months of injury); Asymmetry in the functional use of the upper limbs; Rated motor activities as grade 2 or 3, according to the degrees engines TCI table; Cognition suitable for simple commands and numerical scores.	Having performed the TCP protocol previously; Pain that interferes with activities in therapy and at home; More than two consecutive faults; Having performed peripheral chemical lock before three months of the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-377483	Assessment of pain after adjustment occlusal in root canal treatment	Not yet recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1152	Assessment of postoperative pain after adjustment occlusal in endodontic treatment: a randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Universidade Federal do Amazonas (UFAM)	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-377483	<NULL>	Healthy patients of both sexes (male and female) aged between 18 and 60  who have root canal treatment indication in molars permanent, diagnosed with irreversible pulpitis; presence of occlusal contact prior to endodontic treatment; presence of natural or artificial opposing tooth in the occlusal contact in treated endodontically teeth; to have phone number to contact.	Pregnant women, patients aged less than 18 and greater than 60 years, patients taking some anti-inflammatory medication or antibiotic treatment at the time, immunocompromised, with hypersensitivity to nonsteroidal anti-inflammatory; previous diagnosis of bruxism or clenching; absence of natural or artificial tooth opposite to the tooth to be treated endodontically; complications endodontic type: calcifications, external or internal resorption, partial formation of the apical apex with dental drilling, with longitudinal or vertical fractures and severe periodontal disease; treatments in multiple sessions; patients without phone contact.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-36byz5	The effect of use of probiotic Lactobacillus plantarum in children and adolescents with elevated levels of cholesterol or triglycerides and with nephrotic syndrome	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1153	The use of probiotic L. plantarum in dyslipidemia in children and adolescents with nephrotic syndrome: a double-blind, randomized, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-20	Patrícia Marques Fortes	Hopital das Clínicas da Universidade Federal de Goiás (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-36byz5	<NULL>	"Cases and controls: individuals 2-17 years and 11 months; of both sexes in regular outpatient follow-up for at least 1 year and that have in the last three months:24h proteinuria less than 50 mg / kg / day or 40 mg / m² of body surface area (BSA)Serum Albumin &gt; 2.0 g / dl;
total cholesterol &gt; 170 mg / dl and / or triglyceride levels &gt; 130 mg / dl; preserved renal function (glomerular filtration rate &gt; 60ml / min); in corticoids (prednisone &lt; 1mg / kg / day) and / or cyclosporin 5mg / kg / day; not in use of statins,do not have infectious processes at the time of selection; have not presented clinical or laboratory decompensated SN less than 3 months."	Individuals with kidney disease from stage III; pregnant women; cancer patients; acquired immunodeficiency syndrome, hypothyroidism, metabolic disease; severe cardiovascular disease; cerebrovascular diseas; symptomatic heart failure; viral or bacterial infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-8bsmyz	Evaluation of the simulation in the teaching of respiratory aspiration	Recruitment completed	Intervention	2017-01-16	<NULL>	<NULL>	1154	The use of simulation in teaching airway aspiration technique of lower areal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8bsmyz	<NULL>	Students of both sexes regularly enrolled in the skills I course of the Undergraduate Nursing Course.	Be technical in nursing; already have some knowledge about respiratory aspiration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-8jqrw7	The treatment of caries of children and teenagers in the city of Olinda	Recruitment completed	Intervention	2017-01-16	<NULL>	<NULL>	1155	Doing art in Olinda- the treatment of cavited primary molars of children and teenagers in Olinda City	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-07	Universidade de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8jqrw7	<NULL>	Children and adolescents between 2 and 19 years old of both genders, both female and male; Enrolled in the Family Health Strategy and in the single health system and linked to some school;With decayed primary molars.	"Children less than 2 and more than 19 years;
children with deciduos molars with fistula, mobility and pulp involvement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-9sq542	Efficacy of the treatment of chronic periodontitis with antimicrobial Photodynamic therapy associated with conventional treatment in diabetic patients	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1156	Effectiveness of antimicrobial Photodynamic Therapy (aPDT) as adjuvant therapy in the treatment of periodontitis, in patients with type 2 diabetes melittus: clinical randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-9sq542	<NULL>	Patients aged between 30 and 70 years,both genders, diagnosis of chronic periodontitis with at least 4 places with probing depth (PS) &gt; 5 mm and insertion loss clinic (NIC) &gt; 3 mm with bleeding on probing (SS), Patients diagnosed with diabetes mellitus type 2 (HbA1c &gt; 7%), at least 15 teeth, excluding third molars.	Smokers or ex-smokers more than 12 months; patients with anemia; active cancer patient; history of antibiotic therapy in 6 months; history of anti-inflammatory therapy in the last 3 months; patients with blood disorders; pregnancy; patient in orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4mx7jx	Effects of using Nintendo Wii® video game in patients with Parkinson&apos;s disease to study upper limb function	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1157	Study of non-immersive virtual reality in patients with Parkinson&apos;s disease: funcional analysis in upper extremities	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-15	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Associação Fluminense de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-4mx7jx	<NULL>	Individuals must be between 60 and 70 years old of both genders.To present a diagnosis of Parkinson&apos;s disease classified in stages 2, 2,5 and 3 of the modified scale of Hoehn and Yahr , obtaining more than 13 points in the Mini-Mental State Examination (MMSE) For illiterate, 18 points for low or medium education and 26 for education above 9 years, be able to copy the pentagon and must be without physiotherapy treatment for at least 3 months prior to the training program.	Patients with other neurological and musculoskeletal conditions limiting upper limb function; Unstable heart disease or cardiorespiratory failure; Patients with cognitive limitations who fail to respond to questionnaires and obey verbal and visual commands; Resting heart rate greater than 120 bpm; Systolic blood pressure greater than 180 mmHg and diastolic blood pressure greater than 100 mmHg; Patients whose medication or dose is modified during the training protocol; Patients using a pacemaker or electronic biological device according to the manufacturer of the Nintendo Wii ™.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4jx4fw	Isostretching in low back pain	Not yet recruiting	Intervention	2017-01-17	<NULL>	<NULL>	1158	Isostretching method effect in chronic low back pain treatment in women	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Secretaria Municipal de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-4jx4fw	<NULL>	women with low back pain, no smoker and pain analogic visual scale more than 1	low back surgery, without low back pain diagnosis, low back pain ethiology unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-7yjwpf	Evaluation of the relationship between salt intake and blood pressure in different amounts of salt consumed	Data analysis completed	Intervention	2017-01-17	<NULL>	<NULL>	1159	A double-blind, randomized clinical trial to evaluate the dose-response relationship between salt intake and blood pressure at different levels of salt intake	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-20	Universidade Federal de Goiás	Liga de Hipertensão Arterial do Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7yjwpf	<NULL>	Workers of Campus I of the Federal University of Goiás; Age between 20 and 60 years; Of both sexes.	Blood pressure greater than 160mmHg of systolic and 100mmHg of diastolic independent of the use of hypotensors; Use of more than two antihypertensive drugs or secondary hypertension; Type I and II diabetics; History of atherosclerotic disease; Need for special diet for any reason whether religious, dietary control or syndromes; Do not carry out at least 4 main meals per week, prepared at home, whether lunch or dinner.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-34d7jm	Effects of a dance program in motor and non motor symptoms of patients with Parkinson&apos;s disease.	Recruitment completed	Intervention	2017-01-17	<NULL>	<NULL>	1160	Effects of a systemized dance program in motor and non motor aspects of patients with Parkinson&apos;s disease: a randomized controlled study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-34d7jm	<NULL>	Patients between stages 1 to 3 of the Hoehn &amp; Yahr scale; in regular use of specific medication for Parkinson&apos;s disease.	Cognitive deficits that could affect the understanding of the evaluation protocol and tasks proposed in the intervention groups; auditive and visual problems not corrected; other neurological diseases and musculoskeletal problems that affect the participation in the proposed intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-92md93	Evaluation of Laser Therapy in the Prevention and Treatment of Oral Irritations Due to Cancer Treatment	Recruiting	Intervention	2017-01-18	<NULL>	<NULL>	1161	Evaluation of the Low Intensity Laser in the Prevention and Treatment of Oral Mucositis: Double Blind Randomized Clinical Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-92md93	<NULL>	Group 1: Patients with head and neck neoplasms undergoing radiotherapy;Group 2: Patients with head and neck neoplasms undergoing radiochemotherapy;Group 3: Patients with neoplasias of the gastrointestinal tract under chemotherapeutic treatment (Fluorpyrimidine).	Patients younger than 18 years;Presence of oral ulcerations or erosions;Cognitive deficits;Simultaneous participation in another clinical study;In long-term treatment with photosensitizing agents.Difficulty opening the mouth, such as trismus or maxillo-mandibular block.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-6fk93n	A mode of mechanical ventilation applied without artificial airway in the post operative obesity surgery.	Recruitment completed	Intervention	2017-01-18	<NULL>	<NULL>	1162	Non-invasive ventilation with two pressure levels in the postoperative period of bariatric surgery by Roux-en-Y: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-03	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6fk93n	<NULL>	"Patients with obesity class III and IV according to Brazilian Consensus of bariatric surgery, aged 18-40 years who underwent surgery during the period of the study and agree to participate. 
Patients with comorbidities of type OSA, hypertension, DM 2 and musculoskeletal problems; 
Informed consent approved and signed by the participants."	"Hemodynamic instability (represented by fever, decrease or increase of 20 mmHg of the reference value of blood pressure or heart rate 20 bpm and in severe hypoxemia); 
Patients with claustrophobia as the use of device therapy; 
Patients with difficulty in understanding to perform the maneuvers for breath tests; 
Patients with severe chronic lung disease prior;
Presence of contraindications to NIV: decreased level of consciousness, drowsiness, restlessness, or patient refusal, abdominal distension, nausea and vomiting."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-7h6f6p	Anxiolytic effect of NSR meditation on emotions of university students	Recruiting	Intervention	2017-01-19	<NULL>	<NULL>	1163	Effect of NSR meditation on the anxiety levels of university students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7h6f6p	<NULL>	University students of both sexes, aged between 18 and 30 years who do not present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who did not use chronic medication; who did not present pre-menstrual complaints; and who had no previous experience with meditation or relaxation techniques.	Waiving by the volunteer; who present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who use chronic medication; who present pre-menstrual complaints; and who had previous experience with meditation or relaxation techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-3kgttj	Rehabilitation of elderly using upper complete denture and lower with a single-implant overdenture.	Recruitment completed	Observational	2017-01-19	<NULL>	<NULL>	1164	Masticatory function and quality of life in elderly using single-implant mandibular overdenture.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3kgttj	<NULL>	Elderly patient; total edentulous; should present a reabsorbed border condition according to the classification of The American College of Prosthodontics. In this classification, the patient should present a minimum of 15mm of bone height in some region of the mandible to be included.	Pain symptoms of ATM and chewing muscles; uncontrolled systemic diseases; osteoporosis; head and neck irradiation; smokers and drinkers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-9zgdbb	Viscosupplementation and platelet-rich plasma in knees chondral injuries.	Recruiting	Intervention	2017-01-23	<NULL>	<NULL>	1165	Comparison between viscosupplementation and PRP in Knees chondral lesions in young patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Uniort.E Ortopedia Especializada	Uniort.E Ortopedia Especializada	https://ensaiosclinicos.gov.br/rg/RBR-9zgdbb	<NULL>	Chondral injury in just one knee; age between 20 and 40 years old; both genders; BMI under 30.	Presence of osteoarthritis; allergy to blood components.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-9t2jr8	Effect of an intervention on behavior change in adolescents with Excess of Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned, I taught	Recruiting	Intervention	2017-01-24	<NULL>	<NULL>	1166	"Effectiveness of multidisciplinary intervention based on the Transtheoretical Model
Of Behavior Change for the treatment of adolescents with Excess of
Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned,
I taught"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Universidade Federal de São Paulo	Centro de Recuperação e Educação Nutricional	https://ensaiosclinicos.gov.br/rg/RBR-9t2jr8	<NULL>	Schoolchildren; aged 8 to 12 years; enrolled in the two eligible schools; enrolled in the third, fourth and fifth years of elementary education.	Schoolchildren with cognitive delays selfreported by parents and  or teachers who could limit their involvement in activities such as responding to questionnaires; That have motor limitations to participate in physical activities; that are twins; Who are using known medications that influence body weight; Who have known family problems that could affect overall compliance and participation in the Program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-3phpxb	Electrical stimulation in the brain combined with video game for children with Down&apos;s Syndrome	Not yet recruiting	Intervention	2017-01-24	<NULL>	<NULL>	1167	Virtual Reality and Transcranial Stimulation  direct current for improvement of upper limb motor function in children with Down&apos;s Syndrome: Randomized and double blind controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Nove de Julho	Conselho Nascionla de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-3phpxb	<NULL>	Diagnosis of Down&apos;s Syndrome; Ability to understand and collaborate to carry out the procedures involved in the study; Age between six and twelve years; Complaints of impaired motor coordination of upper limbs; Responsible for their participation in the study by signing the Informed Consent Form.	Have undergone surgical procedures in the last 12 months prior to the start of the training sessions; Have structured orthopedic deformities in the upper limbs or spine with surgical indications; Carriers of epilepsy; Have a metal implant in the brain or hearing aids; Associated neurological pathology; Pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-2hd6sm	Joy Moving: early intervention for children	Not yet recruiting	Intervention	2017-01-25	<NULL>	<NULL>	1168	Early physical activity: evaluation proposal, monitoring and early intervention program and aquatic therapy in children	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2hd6sm	<NULL>	Typical children will be included and / or developmental delay; age 0-6 years; both sexes; parental consent	children with health contraindications to practice exercises; injuries or health conditions that contraindicate exercises in water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-3qd5gf	Quality of life of diabetics and hypertensives from a basic health unit in Guarapuava / PR	Data analysis completed	Observational	2017-01-26	<NULL>	<NULL>	1169	Quality of life of the users of the Hiperdia group of the unit basic health: Recanto Feliz in Guarapuava / PR.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-3qd5gf	<NULL>	Users of the basic health unit with systemic arterial hypertension and / or diabetes mellitus of both sexes enrolled in the SisHiperdia program under follow-up by the primary health unit team, users aged over 18 years, individuals who are aware of the research development and who Accepted the conditions established in the work and specified in the term of free and informed consent	Individuals with temporary residence in the neighborhood where the basic health unit is located, travelers from other neighborhoods, illiterates, children and users unable to respond to the questionnaire due to cognitive, neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-287qk4	(Con) Living with carpal tunnel syndrome severe degree: patients´report	Not yet recruiting	Intervention	2017-01-06	<NULL>	<NULL>	1170	(Con) Living with carpal tunnel syndrome severe degree: everyday narratives	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-287qk4	<NULL>	People of both sexes, medical diagnosis of carpal tunnel syndrome; test electromyography to report to carpal tunnel syndrome severe degree; pain and symptoms present for at least six months and positivity for the Phalen and Tinel tests.	History of trauma or previous surgery in the dominant upper limb or spine; subluxation of acromioclavicular and glenohumeral joint; osteoarthritis of joint complex of the elbow, wrist and hand; tendinopathy in joint complex of elbow, wrist and hand; diagnosis of rheumatic, degenerative or neurological disease; physical therapy and/or occupational therapy or use of orthosis in the last three months before entering the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-2s7j59	Effect of telephone follow-up to improve self-efficacy, duration and exclusivity of breastfeeding	Data analysis completed	Intervention	2017-01-26	<NULL>	<NULL>	1171	Effects of a telephone educational intervention on the self-efficacy, duration and exclusivity of breastfeeding: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s7j59	<NULL>	Women in the immediate puerperium; With at least six hours postpartum; With single, full-term gestation; With newborns hospitalized in the joint housing; Who are carrying out the practice of Breastfeeding; Have at least one telephone contact.	Puerperas that had been contraindicated to breastfeeding; With mental restrictions that made it impossible to understand the instrument; With children hospitalized in the intensive care unit; Whose children were born with disabilities that impede breastfeeding; Hearing impaired.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-9zbk7y	Effects of virtual reality on the balance and mobility of elderly people living in nursing homes	Recruitment completed	Intervention	2017-01-26	<NULL>	<NULL>	1172	Comparison of balance and mobility in postgraduate institutionalized elderly with virtual rehabilitation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-11	Faculdade de Filosofia e Ciencias- UNESP Marilia	Faculdade de Filosofia e Ciencias- UNESP Marilia	https://ensaiosclinicos.gov.br/rg/RBR-9zbk7y	<NULL>	Elderly people of both sexes; Institutionalized; Aged 65 or over; Good health condition; Good visual acuity or corrected visual acuity; Do not use polypharmacy, especially anti-hypnotics and antidepressants; It is a condition for the elderly to be able to stand without resting feet.	Elderly people over 85 years or younger than 65; With osteoarticular diseases; With neurological diseases; Elderly people who can not stand erect without support and / or with united feet; With hearing loss greater than 70%; Reduced visual acuity without correction; Making use of polypharmacy, including antidepressant and hypnotics; Hypotension	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-95tt75	Presence of bone, joint and muscle pains in farmers who grow tobacco in the city of Prudentópolis-PR	Data analysis completed	Observational	2017-01-27	<NULL>	<NULL>	1173	Incidence of musculoskeletal pain in smokers in the city of Prudentópolis-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Faculdade Guairacá (Centro Coordenador)	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-95tt75	<NULL>	Tobacco-producing farmers; male; age from 20 to 45 years; agree to participate in the research and sign the informed consent form.	Hearing deficiency; physical disability; cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-9d8xr6	Benefits of aquatic physiotherapy in the health of the elderly	Data analysis completed	Intervention	2017-01-30	<NULL>	<NULL>	1174	Contribution of aquatic physiotherapy in the health of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-9d8xr6	<NULL>	Elderly people aged 60 to 80 years; Of both genders; Who frequent the HIPERDIA group; That present independent gait and independence in activities of daily living (ADLs). Individuals should be aware of the research and that they accept the conditions established in the work and specified in the Informed Consent Term (ICT).	Elderly without dermatological medical certificate favorable to aquatic physiotherapy; Urinary or fecal incontinence; Presence of open wounds, probes, tracheostomies, infectious cutaneous diseases, neurological diseases, infectious diseases, renal insufficiency, heart disease without cardiologist&apos;s authorization, severe pneumopathies, uncontrolled hypertension or above 160 X100 mmhg, vascular thrombi, Severe cognitive and auditory deficits, severe osteomioarticular pathologies, physical deficiency; Participation in other physical activities or even Aquatic Physiotherapy less than 6 months or that are in another type of moderate physical activity supervised with two or more times in the week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-57s29p	The benefits of dance in quality of life and depression in the elderly from  Boa Ventura de São Roque-PR	Data analysis completed	Observational	2017-01-30	<NULL>	<NULL>	1175	Quality of life and depression in a group of seniors from Boa Ventura de São Roque-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-57s29p	<NULL>	60 to 85 years; both sexes.	Severe cognitive impairment; orthopedic or neurological changes that moderately affect functional capacity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-82qf9m	Occurrence of sensitivity evaluation with and without sonic activation of a desensitizing gel before in office bleaching in adults	Data analysis completed	Intervention	2017-03-03	<NULL>	<NULL>	1176	Sensitivity absolute risk evaluation with and without sonic activation of a desensitizing gel previously to in office bleaching in adults	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2016-01-20	Verônica Pereira de Lima Bertocco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-82qf9m	<NULL>	Patients aged 18 years and over, upper teeth free of caries and the anterior superior free of restorations in the vestibular face, besides central incisors or canines presenting A2 or darker coloration, evaluated in comparison with a visual scale of color guided by the value Of teeth (Vita Classical, Vita-Zahnfabrik- Germany).	Pregnant or lactating women, smokers, users of fixed orthodontic appliances, individuals with severe intrinsic stains on the teeth (spots on the use of tetracycline, fluorosis and depolluted teeth), users of antiinflammatory and antioxidant drugs and participants with a previous history of tooth sensitivity or any Associated pathology (bruxism, gingival recession, non-carious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-8r3b7y	Clinical avaliation of patients with intestinal neuronal dysplasia after a long time period	Recruiting	Observational	2016-09-28	<NULL>	<NULL>	1177	Long term clinical follow up in patients with intestinal neuronal dysplasia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-03-06	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-8r3b7y	<NULL>	patients who had received histopathological diagnosis of Intestinal Neuronal Dysplasia type B; that have been diagnosed and treated for over 5 years; have agreed to participate in the study; signed informed consent term.	Refuses to participate in the study; less than 5 years after initiation of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-8bwz7r	Does the enamel surrounding carious lesions influence the success of adhesive restorations in primary molars?	Recruiting	Intervention	2017-03-06	<NULL>	<NULL>	1178	Does the use of rotary instruments in the cavo-superficial enamel influences the survival of composite resin restorations in primary teeth submitted to selective removal of carious tissue?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-07	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8bwz7r	<NULL>	Children from 5 to 9 years old; Primary molas - ICDAS 5; Without restoration or other lesions that interfere with the lesion to be treated	Children with difficult behavior; Tooth without antagonist; Lesions involving more than one surface; Painful symptomatology; Signs of pulpal alteration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-4n67h3	Prevention of tuberculosis  in prisions.	Not yet recruiting	Intervention	2016-12-16	<NULL>	<NULL>	1179	Primary prophylaxis for prevention of TB in prison&apos;s populations.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Ministério da Ciência, Tecnologia, Inovações e Comunicações	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4n67h3	<NULL>	Minimum stay estimated at 24 months under a closed regime; age between 18 and 45 years; without active tuberculosis or previous use of isoniazid; without consuming alcohol at least 3 months.	Positive serology for HIV, hepatitis B and C; latent tuberculosis; liver enzymes three times the upper limit; use of any medication that influence the metabolism of P450 enzyme; acute or chronic renal failure; epilepsy; indigenous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-4mkg73	Lifestyle intervention in pregnant women.	Data analysis completed	Intervention	2017-03-07	<NULL>	<NULL>	1180	Impact of an intervention for promotion leisure-time walking and healthy eating among pregnant women in antenatal care.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Faculdade de Medicina, Universidade Estadual Paulista Julho de Mesquita Filho, Botucatu-SP	Faculdade de Saúde Pública, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mkg73	<NULL>	pregnant women enrolled in the antenatal low-risk public health system in the urban area of Botucatu-SP; aged equal to or greater than 18 years old; being in the first trimester.	prenatal care in private health services; change city; Suffer abortion; Have high obstetric risk (pre-eclampsia,gestational diabetes).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-5r5sc5	Anxiety and singing: influence of administration of a single dose of Oxytocin in men	Recruiting	Intervention	2017-03-08	<NULL>	<NULL>	1181	Anxiety and singing voice: clinical parameters and effects of acute administration of Oxytocin in men	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-10-20	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5r5sc5	<NULL>	Male singers; Aged between 18 and 35 years; With training or experience in singing voice of at least three years; Perform at least one musical presentation in public.	Use of the following medications; Antihistamine, antidepressants, antihypertensive, hypoglycemic and anti-inflammatory; Complaint of auditory acuity; History of neurological disease, psychiatric disorders, renal, pulmonary, hepatic and / or cardiovascular problems; Abuse of alcohol, tobacco and users of illicit substances; Moderate to severe dysphonia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-83dk7z	Colostrum administration in very low birth weight preterm infants - clinical trial	Recruiting	Intervention	2017-01-25	<NULL>	<NULL>	1182	Oral immunotherapy in very low birth weight preterm infants - randomized double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital Moinhos de Vento	Faculdade de Medicina da Pontífice Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-83dk7z	<NULL>	Premature inborn at Hospital Moinhos de Vento; with birth weight equal to or below 1500 grams; and/or gestational age equal to or less than 30 weeks; admitted to the NICU.	Malformations incompatible with life; malformation of the gastrointestinal tract; contraindication to breast milk; death in the first 6 days of life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-6bsngd	Aerobic training in different volumes and intensities in schoolchildren with risk factors for metabolic syndrome	Recruitment completed	Intervention	2017-03-10	<NULL>	<NULL>	1183	Effects of aerobic training in different volumes and intensities in schoolchildren with risk factors for metabolic syndrome.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-22	Universidade Estadual de Maringá	UNESPAR/ Campus Paranavaí	https://ensaiosclinicos.gov.br/rg/RBR-6bsngd	<NULL>	Be properly enrolled in any school; Be between 10 and 18 years old; To present a free and informed consent form signed by the parents or guardians; Present medical release for physical activity	Do not be aged between 10 and 18 years; Have some physical or mental deficiency; Use controlled medications; Do not present auotorization of the parents and the doctor to practice physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-32m5b8	Use of knee braces in sports.	Recruiting	Observational	2017-03-13	<NULL>	<NULL>	1184	Use of knee braces in sports.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Uniort.E Ortopedia Especializada	Uniort.E Ortopedia Especializada	https://ensaiosclinicos.gov.br/rg/RBR-32m5b8	<NULL>	both genders; above 18 yo; during exercise; wearing knee braces.	Do not agree to participate in the project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-6974xz	Maternal behavior for prevention of childhood diarrhea: clinical trial with different technologies	Recruitment completed	Intervention	2017-03-15	<NULL>	<NULL>	1185	The use of educational technologies to promote maternal self-efficacy in the prevention of childhood diarrhea	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6974xz	<NULL>	Mother of at least one child under the age of five and have a cell phone or landline.	Mother less than 18 years old or with cognitive limitation that prevents her from participating in any educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2gqmvf	Performance of two adhesives in restoration of cervical lesions: a clinical trial	Recruiting	Intervention	2017-03-17	<NULL>	<NULL>	1186	Performance of universal adhesive systems in different etching strategies in non-carious cervical lesions: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-13	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-2gqmvf	<NULL>	to have at least 4, 8 or 12 teeth with non-carious cervical lesions (LCNC) on the vestibular face of anterior or premolar teeth;  lesions being caries-free and non-retentive; lesions with depth greater than 1mm; in vital teeth and without mobility; to be in good health; at least 18 years old; be able to understand and sign the informed consent form; oral hygiene in an acceptable level; present at least 20 teeth in occlusion; be willing to return the reevaluation consultations.	Teeth with considerable or severe dentinal hypersensitivity; teeth without pulp vitality to the thermal test; absence of antagonistic tooth; patients in orthodontic treatment; patients with severe bruxism with wear facets corresponding to more than 50% of dental structure; extremely poor oral hygiene; with severe or chronic periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-3nqdw5	Study of adherence to smoking cessation treatment in two groups of patients, one with treatment determined by physician and the other with a patient participation in decisions .	Recruitment completed	Intervention	2016-10-11	<NULL>	<NULL>	1187	Study of adherence to smoking cessation treatment in two groups of patients, one with treatment determined by physician and the other with a shared decision.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Faculdade de Medicina da Universidad Federal da Bahia	Programa de Pos-graduação em Medícina e Saude	https://ensaiosclinicos.gov.br/rg/RBR-3nqdw5	<NULL>	Having diagnosis of dependence Tobacco according to the DSM-5 V and the &quot;Smoking Treatment Guide&quot; by INCA; Want to quit smoking (the patient should be in the contemplation or action stage )	Patients with a mental disorder that compromises the decision making about treatment; patients who have criteria for abuse and / or dependence on other drugs that compromise the decision-making about treatment; patients who in the moment are in treatment for smoking (Patients transferred).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-4vktzw	Effects of intervals between sets on bodybuilding	Recruitment completed	Intervention	2017-03-17	<NULL>	<NULL>	1188	Effect of different recovery intervals between sets in resistance exercises to concentric failure in physically active individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Federal de Alfenas	Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4vktzw	<NULL>	Physically active men with previous experience of at least six months in resistance training, with at least three weekly sessions.	Change in health condition; Nutritional or pharmacological supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-934sys	Clinical evaluation of pain during gum treatment using anesthetic gels with no needles.	Recruitment completed	Intervention	2017-03-23	<NULL>	<NULL>	1189	Clinical evaluation of pain perception during scaling and root planning, using non-invasive lidocaine/prilocaine thermosetting liposomal anesthesia gel.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-01	Universidade Estadual de Ponta Grossa	Curso de Odontologia - Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-934sys	<NULL>	Healthy volunteers, any gender, older than 18 years, at least three sextants who require periodontal treatment, at least one tooth with clinical depth of probing &gt;= 4mm.	Volunteers under periodontal maintenance, sensitivity or allergy to amide-based anesthetics, use of analgesic or anesthetic medication at least 12 hours prior to the procedure, previous history of alcoholism, pregnant or lactating women, uncontrolled severe systemic disease, acute local pathological alterations, dental extraction needs, dentin hypersensitivity and endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-3pq58k	Walking training in intermittent claudication: physiological responses assessed at rest and after maximal exercise	Recruitment completed	Intervention	2017-03-24	<NULL>	<NULL>	1190	Walking training in intermittent claudication: functional, hemodynamic, autonomic, inflammatory, oxidative stress and genetic regulatory responses measured at rest and after an acute exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-04	Escola de Educação Física e Esporte da Universidade de São Paulo	Ambulatório de Claudicação Intermitente do Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3pq58k	<NULL>	"Men; Age between 50 and 80 years; Ankle-brachial index &lt; 0.90 at rest in 1 or 2 legs; Patients with Fontaine stage II symptoms; Able to walk
for at least 2 min at 3.2 km/h on a treadmill; Not users of peripheral vasodilators, clopidogrel, beta blockers or 
nondihydropyridine calcium channel blockers."	Presence of muscle or skeletal disorders that precludes exercise execution; systolic and/or diastolic, respectively, greater than 140 and 90 mmHg; obesity level II or greater; Presence of   complex  arrhythmias  and/ or ischemia  during  exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-48z55v	Comparison between two types of peripheral vein catheter	Recruitment completed	Intervention	2017-03-24	<NULL>	<NULL>	1191	Effectiveness of peripheral venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-21	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-48z55v	<NULL>	Age over 18 years; being hospitalized in research units; requires obtaining peripheral intravenous access for intravenous therapy.	Present peripheral venous fragility or any other condition that could impair the puncture with peripheral intravenous catheter; insertion of the catheter in the external jugular vein; have previously participated in the search, regardless of randomization group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2pr7zp	Effects of unmetabolized folic acid on DNA modifications, messenger RNA expression and in the function of blood NK cells in individuals who consume folic acid in fortified flours or as a vitamin supplement.	Data analysis completed	Intervention	2017-03-27	<NULL>	<NULL>	1192	Effects of unmetabolized folic acid on global DNA methylation, mRNA expression and NK cells citotoxicity in individuals exposed to mandatory fortification with folic acid and/or therapeutic use of this vitamin	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2pr7zp	<NULL>	Healthy subjects; both sexes; aged between 18 and 45 years.	Individuals under 18 years, chronic alcoholics; patients with acute or chronic diseases; pregnant women; users of immunosuppressive medications, vitamins or vitamin supplements; blood donors in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-7dkf7k	Genetic markers and their association with resting energy expenditure in women with severe obesity before and after bariatric surgery	Recruiting	Intervention	2017-03-27	<NULL>	<NULL>	1193	Molecular markers related to energy metabolism and its association with substrate oxidation and resting metabolic rate in women with grade III obesity pre and post bariatric surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7dkf7k	<NULL>	Women with indication for bariatric surgery using the Roux-en-Y gastric bypass technique; For the eutrophic group will be selected women with nutritional classification of eutrophy, according to the body mass index.	Will be excluded from the study of patients who present modification in the standard surgical technique, loss of follow-up with staff, pregnant women, thyroid diseases, psychiatric disorders and cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-5mr2zq	"Effect of high folic acid levels on enzymes activity and its relation with
expression of genes related to folate metabolism"	Recruiting	Intervention	2017-03-27	<NULL>	<NULL>	1194	"Effect of high folic acid levels on DHFR activity and its relation with
mRNA expression of genes related to folate metabolism and inflammatory cytokines"	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-11-01	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5mr2zq	<NULL>	For the group of non-pregnant women with a history of primary miscarriage: women aged 18-40 years; at least two histories of recurrent spontaneous miscarriage; no viable fetus; in use of 5 mg of folic acid daily. For the prospective study with intervention of 5 mg of folic acid per day: healthy volunteers; both sexes, from 18 to 45 years, non smokers.	Women with a history of abortion who are pregnant during study enrollment. For the study with intervention of 5 mg of folic acid per day will be excluded chronic alcoholics; patients with chronic diseases; pregnant women; smokers; individuals who underwent major surgery to less than 6 months or donated blood in the last 3 months; and Those who have used polivitamins in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-4rwr8k	Palliative care and heart failure: Comfort through nursing	Recruitment completed	Intervention	2017-03-27	<NULL>	<NULL>	1195	Palliative care in heart failure: the comfort as an outcome of nursing care.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-30	Instituto Nacional de Cardiologia	Serviço de Insuficiência Cardíaca e Transplante	https://ensaiosclinicos.gov.br/rg/RBR-4rwr8k	<NULL>	"Volunteers with chronic heart failure of any etiology having been diagnosed for more than 1 year and optimizing drug therapy at the time of study entry; or
Volunteers with chronic heart failure of any etiology with diagnosis less than 1 year, associated with 2 or more hospitalizations due to decompensated HF, or 1 hospitalization in the last year with venous amines use; Being in New York Heart Association (NYHA) III or IV Functional Class at time of enrollment; Have left ventricular ejection fraction (EF) &lt;30%, documented before inclusion, as measured by two-dimensional echocardiography; Both sexes aged&gt; 18 years; Be regularly followed at the HF clinic of the research institution;"	Volunteers who have any other clinical condition that implies a life expectancy less than 6 months after the start of the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-2ffv9g	Evaluation of respiratory physiotherapy in infants with Tachypnea	Data analysis completed	Intervention	2017-03-24	<NULL>	<NULL>	1196	"Evaluation method thoraco-abdominal 
In newborn  with transient tachypnea diagnostic"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-22	Universidade Federal Fluminense	Fundação Educacional Serra dos Órgãos - FESO	https://ensaiosclinicos.gov.br/rg/RBR-2ffv9g	<NULL>	"We included in the study, Newborn with diagnosis of Transient tachypnea of the newborn admitted to the Neonatal Intermediate Unit.
Gender both sexes."	Newborn with tachypnea, whose etiology was related to Central Nervous System (CNS) alterations, cardiac alterations or malformations, hematological alterations or the presence of any congenital malformation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-6nk57z	The efficacy of the use of the semipermeable membrane in the maintenance of thermoregulation of the preterm newborn in the neonatal intensive care unit.	Recruitment completed	Intervention	2017-03-28	<NULL>	<NULL>	1197	The efficacy of the use of the semipermeable membrane in the maintenance of thermoregulation of the preterm newborn in the neonatal intensive care unit.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6nk57z	<NULL>	The newborn should have weight less than 1,500 grams, have gestational age less than 34 weeks, Independent of sex.	The newborn with serious defects and integrity of compromised skin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-46xj92	Effects of laser on strength and muscle fatigue	Recruiting	Intervention	2017-03-29	<NULL>	<NULL>	1198	Immediate effects of low-level laser therapy (780 nm) in muscle fatigue and metabolic performance: a randomized, crossover and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Centro Universitário Uninovafapi	Centro Universitário Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-46xj92	<NULL>	Young men; aged between 18 and 25 years; apparently healthy; sedentary.	Individuals who presented with a musculoskeletal disease or trauma in the last three months; those who took supplements or use of medication during the period of their participation in the study; not have consumed alcohol, large amounts of tea or coffee (more than two cups), or any other caffeine-rich food 24 hours before the test; have slept at least 8 hours  the night before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-5gkhhj	The effects of beet and grape juice consumption and exercise on blood pressure and glycemia in patients with excess weight and high glycemia	Recruiting	Intervention	2017-03-30	<NULL>	<NULL>	1199	Effects of dietary nitrate supplementation and exercise on hemodynamic variables and oxidative stress in subjects with overweight and hyperglycemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-15	Ana Paula Trussardi Fayh	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5gkhhj	<NULL>	Participants should be overweight or obese (Body Mass Index equal to or greater than 25 kg/m² and less than 40 kg/m²) and present hyperglycemia (glycemia equal to or greater than 100 mg/dl); non smokers; Are not physically active and are releasing your physician for exercise.	Smoking participants; Alcoholics; obese degree III (body mass index equal to or greater than 40 kg/m²); In the physical activity readiness questionnaire and in the Rose questionnaire do not show to be able to carry out the evaluations; Present cardiovascular, respiratory, neuromuscular, osteoarticular and other conditions that are not indicated or are not advisable to carry out stress tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-92b9dg	Hemolysis and inflammatory response to extracorporeal circulation during on-pump coronary artery bypass graft surgery: comparison between roller and centrifugal pump systems	Data analysis completed	Intervention	2017-03-30	<NULL>	<NULL>	1200	Comparative analysis of the incidence of hemolysis and systemic inflammatory response induced by extracorporeal circulation in the roller pump and in the centrifugal pump in the perioperative period of myocardial revascularization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-14	Hospital das Clínicas da Faculdade de Medicina de Botucatu (FMB) da Universidade Estadual Paulista (Unesp)	Universidade Estadual Paulista-Unesp, Faculdade de Medicina de Botucatu.	https://ensaiosclinicos.gov.br/rg/RBR-92b9dg	<NULL>	Adult patients with coronary artery disease with surgical indication for myocardial revascularization with extracorporeal circulation, aged between 30 and 80 years of age, with and without associated diseases, with people of both sexes.	Adult patients requiring other cardiovascular surgeries (valve, congenital, aortic), coronary artery bypass grafting with associated carotid artery surgery; Anemia prior to surgery; Inflammatory or infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-26qt3h	Brief intervention in group performed by nurses in the hazardous alcohol use	Data analysis completed	Intervention	2017-03-31	<NULL>	<NULL>	1201	Effectiveness of brief intervention in group performed by nurses in the hazardous alcohol use	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Escola de Enfermagem Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-26qt3h	<NULL>	People older than 18 years; with availability to attend the group for the time and given time; who could read and write; available to receive follow-up.	People with visible behavioral changes; intoxicated; not available to participate in the proposed intervention;  who refused to receive the follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-6yppv3	Comparison of minimally invasive techniques in the treatment of severe varices	Recruiting	Intervention	2017-04-03	<NULL>	<NULL>	1202	Comparison of efficacy and safety in the treatment of severe chronic venous insufficiency: endovenous radiofrequency ablation versus endovenous laser ablation versus foam sclerotherapy versus elastic compression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-25	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6yppv3	<NULL>	The study will include male and female patients 18 years old or older, with no limits on the maximum age,with active venous ulcers (CEAP 6),primary varicose veins documented by ultrasound,and who agreed to the terms of the studyand signed the free, prior, and informed consent (FPIC).	Patients under 18 years of age; with venous anomalies (e.g. angiodysplasia); with history of deep venous thrombosis and post-thrombotic syndrome; in use of anticoagulants; varicose veins classified as CEAP 5 or less; who had previous saphenectomy in the affected limb; without surgical or anesthetic conditions; with ulcers with signs of active infection; pregnant, postpartum or breastfeeding women; patients with history of migraine; history of interatrial or arteriovenous communication; with active cellulitis or erysipelas; abnormal laboratory liver or kidney function (creatinine clearance below 30ml/m); with signs of active skin mycosis; with previously known retinal changes; history of alcohol or drug abuse; signs of arterial insufficiencyclinically present; signs of clinically decompensated comorbidities; who do not agree with the terms of the study or refuse to sign the free and informed consent (FPIC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-4vw9ps	Use of non-pharmacological measures to reduce the pain suffered during the arterial puncture	Recruitment completed	Intervention	2017-04-04	<NULL>	<NULL>	1203	Clinical care nurses in reducing pain suffered by the newborn in blood punch: study interventions with non-pharmacological measures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4vw9ps	<NULL>	Newborns with gestational age less than 37 weeks requiring arterial puncture that are in the first seven days of life, regardless of weight. Newborns of both male and female are included.	Newborns with congenital malformation, patients with neurological disorders and use of sedative and hypnotic drug.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-8rqy3z	Herbal medicine for relief of oral mucositis.	Recruitment completed	Intervention	2017-04-04	<NULL>	<NULL>	1204	Formulation and clinical trial randomized double-blind herbal medicines with prophylactic and curative purposes of oral mucositis (Phase I)	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2017-02-09	Finep Financiadora de Estudos e Projetos	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rqy3z	<NULL>	Healthy volunteer, both genders; nonsmokers; over 18 years.	Patients with severe systemic disease; historic allergy; smokers; historic aphthous ulcers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-4wfh7y	Activation Following the evaluation of the hip muscles and lumbar spine after the application of techniques to relief back pain	Recruitment completed	Intervention	2017-04-05	<NULL>	<NULL>	1205	Activation sequence of the evaluation of lumbopelvic muscles after application of analgesia techniques	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-27	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4wfh7y	<NULL>	male and female; aged  20-60 years old, body mass índex: 18 - 25 kg / m2 ; screening performed in Spinal Outpatient Clinic Maria da Glória of the Federal University of Triangulo Mineiro; sedentary or regular physical activity practitioners will be forwarded to the Glory Marida Clinic of the Federal University of Triangulo Mineiro; persistent pain between the last rib and the gluteal fold in a period exceeding three months; no history of previous spinal surgery, spinal fractures, neurological disorders, tumors, osteoporosis and arthrosis advanced; complain of pain greater than 0 in the visual analogue scale; not present diagnosis of psychiatric disorder, cognitive impairment or difficulties in understanding and communication that could compromise the use of electrotherapy or spinal manipulation	Diagnosis of a new disease or trauma to the spine and / or lower limbs in the period between the intervention and the follow-up study; fouls two consecutive sessions during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-8h93y9	Memory training for health older adults	Recruitment completed	Intervention	2017-04-06	<NULL>	<NULL>	1206	Working Memory Training for healthy older adults: impact the number of sessions and schooling of participants on the effectiveness of intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-10	Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Capes	Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h93y9	<NULL>	to be between 60 and 75 years of age, be female or male, to be between 4 and 11 years of schooling, to have expected performance for their age and schooling in cognitive screening tests (being considered an elderly person with preserved cognition), have attended all training sessions, and have performed all assessments.	have a diagnosis of neurological or psychiatric disorders, have uncontrolled chronic diseases, have signs of depression or anxiety (scores&gt; 5 on the Geriatric Depression Scale and / or&gt; 9 on the Geriatric Anxiety Inventory), have functional limitations In the Functional Activities Questionnaire of Pfeffer&gt; 1), there is presence of sensory and / or motor limitation that may hinder participation in training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-42ts9g	Study about arrangement of teeth in complete dentures of patients with resorbed edges	Recruiting	Intervention	2017-04-06	<NULL>	<NULL>	1207	Impacct of occlusal pattern  on the prognosis of conventional complete denture patients with resorbed edges	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2016-07-01	André Gustavo Paleari	Faculdade de Odontologia da Universidade Federal de Alfenas (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-42ts9g	<NULL>	Healthy volunteers; both genders; age between 50 and 70 years; total edentulism of mandible and maxilla for at least one year; bone height less than 25 mm and 16 mm in the mandibular symphysis region and mental foramen, respectively.	Volunteers with a history of alcohol or drug abuse; temporomandibular disorders; maxillary or mandibular hyperplasias or exostoses; Diagnoses of uncontrolled cardiac or psychiatric conditions; unable to attend the return visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-535hcn	Evaluation of the Efficacy of a Cognitive-Behavioral Therapy in the Management of Stress, Burnout and Sleep Disorders	Recruiting	Intervention	2017-04-06	<NULL>	<NULL>	1208	Efficacy of Biofeedback in Stress Management, Burnout, and Sleep Disorders in Nursing Academics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-13	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-535hcn	<NULL>	Nursing students from the first to fourth year; Healthy; Of both genders; With age equal to or greater than 18 years.	Students with a diagnosis of coronary artery disease, heart failure, arrhythmia, renal disease, systemic arterial hypertension, hypoglycemia, hypothyroidism; Psychiatric diagnosis by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders - IV (DSM-IV); Make use of heart pacemaker; Make use of beta-blocker medicine; Removal due to compulsory curricular traineeship, suspension, maternity leave or illness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-3mbdx6	Led treatment for burn healing	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1209	Low intensity led therapy (658nm) for burn healing: a non-randomized, double-blind and controlled clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Universidade Estadual do Piauí	Centro Universitário Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-3mbdx6	<NULL>	They nedd to have a seconddegree burn in the region of the arm, forearm, thorax or lower limbs; age between 18 and 60 years;to be in the hospital for second  degree burn treatment in the Burn Therapy Unit; to be hemodynamically stable according to  blood pressure, diuresis, heart rate and respiratory rate, axillary temperature and transcutaneous oxygen saturation.	Patient with blood dyscrasia with predisposition to hemorrhage; presence of gangrene, renal failure, pregnancy or photosensitivity; bacterial infection at the burn site; patient with hypotension, tachycardia, tachypnea, oliguria or cyanosis; patients with comorbidities that may interfere with the healing process, such as: diabetes mellitus, malnutrition, obesity and smoking; patients who use illicit drugs or medications that interfere with the healing process of wounds, such as: chemotherapy and antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-35kjvg	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	Not yet recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1210	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-18	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35kjvg	<NULL>	Patients with head and neck cancer (oral cavity, oropharynx, hypopharynx and larynx); both sexes; aged 18 years and over, submitted to radiotherapy as a first-choice treatment or as adjuvant treatment (post-surgical).	Patients using parenteral nutrition; without cognitive ability to understand the concepts of the questionnaires; in palliative radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-993bxy	Safety and whitening effectiveness evaluation of the combined use of the whitening strip iStrip and the photo activator equipment iDental Whitening for the use of the whitening strip iStrip alone	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1211	EN17-0067-01 - Comparative randomized clinical study for safety evaluation of the use and whitening effectiveness of the product iStrip – Dental whitening for the combined use of the product iStrip - Dental whitening and the photo activator equipment iDental Whitening	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-03-13	Basal Comércio, Importação e Exportação Ltda	Basal Comércio, Importação e Exportação Ltda	https://ensaiosclinicos.gov.br/rg/RBR-993bxy	<NULL>	"Both male and female volunteers between 25 and 55 years old;
Volunteers with dental indication for homemade teeth whitening;
Intact buccal mucosa;
Patient&apos;s agreement to follow the procedures of the study and be in the clinic on specific days and times;
Reading, understanding, agreeing and signing of the patient on the Free and Informed Consent Term"	"Pregnancy;
Lactation;
Volunteers suffering from very sensitiveteeth with exposed cervical areas may limit the treatment or make it unfeasible;
People with teeth severely stained by tetracycline grade III;
People with teeth featuring enamel hypoplasia and white areas;
Volunteers who fail to quit smoking during treatment;
Volunteers with canker sores or mouth sores;
Volunteers submitted to oral surgery in the last 03 months;
People with teeth widely restored featuring surface shape, contour and/or texture changed;
People with multiple erosion/abrasioninjuries;
Volunteers with sensitivity in the cervical region of teeth;
Active cancer or history of cancer in areas where the treatment will be carried out;
History of collagen disorder, including keloid formation or history of poor wound healing;
Any blood clotting disorder;
History of immunosuppressive diseases (including HIV infection);
Use of photosensitizing drugs;
Patients with diabetes;
Other conditions considered by the investigator as reasonable to disqualify the participation of the individual in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-76pm35	Analysis by endoscopy in patients with cirrhosis of the liver and varicose veins in the esophagus that are treating osteoporosis with risedronate medicine	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1212	Endoscopic analysis of cirrhotic patients with esophageal varices in treating osteoporosis with risedronate	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-19	Fundação de amparo a pesquisa do estado de São Paulo- FAPESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-76pm35	<NULL>	Volunteers with hepatic cirrhosis, esophageal varices and osteoporosis or osteopenia; age greater than 18 years; physical and mental conditions of ingesting medications; agreement to sign the informed consent form.	Severe psychiatric illness; upper gastrointestinal bleeding in the last 6 months; esophageal varices of large caliber; renal insufficiency; active peptic ulcer; esophageal stricture; achalasia; gastroparesis; current use of anti-inflammatories, anticoagulants, platelet anti-aggregants and alcoholic beverage; gestation or lactation; neoplasms of the esophagus, stomach or duodenum; hypersensitivity to bisphosphonates; absolute contraindication to endoscopy; advanced cirrhosis; advanced hepatic encephalopathy; previous liver transplantation; use of hormone replacement therapy; primary hyperparathyroidism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2wb25n	The effect of elastic band in patients with Chronic Obstructive Pulmonary Disease	Recruitment completed	Intervention	2017-04-11	<NULL>	<NULL>	1213	Kinesio taping in patients with exacerbation of Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-02	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2wb25n	<NULL>	Patients hospitalized for clinical criteria for exacerbation of Chronic Obstructive Pulmonary Disease; patients who received physical therapy prescription on the first day of hospitalization.	Inpatients in the intensive care unit; non-collaborative patients who were unable to perform respiratory evaluation methods through manovacuometry, microspirometry, and expiratory Flow Peak instruments; those who reported previous thoracic surgery or who presented with chest deformities, or any complications that made kinesio taping difficult to use; those who reported allergic skin reactions with the use of plaster, micropore or other adhesive material.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-9gnhth	Efficacy and sensitivity of home bleaching vs tooth whitening associated with desensitizer.	Recruitment completed	Intervention	2017-04-17	<NULL>	<NULL>	1214	Effectiveness and tooth sensitivity of at-home dental bleaching with 4% hydrogen peroxide vs associated dental bleaching with 35% and 4% hydrogen peroxide with desensitizing - randomized clinical study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9gnhth	<NULL>	Patients older than 18 years of age, male and female, with good general and oral health, teeth free of caries lesions, have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Patients who have undergone dental bleaching, who have dental prostheses or restorations in the upper anterior teeth, who are pregnant or breastfeeding, have gingival retractions, dental sensitivity, endodontic treatment in the upper anterior teeth, severe dental dimming By tetracycline, fluorosis or endodontia), non-carious cervical lesions, fixed orthodontic appliance, habits of bruxism, smoking and visible cracks in the teeth and that are making continuous use of some medication, such as analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-9kwjgx	Acupuncture in the care of nausea and vomiting after surgery	Not yet recruiting	Intervention	2017-04-17	<NULL>	<NULL>	1215	The use of acupuncture in the prevention of nausea and vomiting postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Departamento de Anestesiologia da Faculdade de Medicina da Universidade Estadual Paulista	Faculdade de Medicina da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9kwjgx	<NULL>	female patients , aged 18 to 65 years , physical status I and II according to the American Society of Anesthesiologists ( ASA ) , undergoing abdominal elective gynecological surgery ( hysterectomy) under total intravenous anesthesia.	patients under 18 years , ASA III or IV , unable to report or respond to protocol , fear of acupuncture needle , inability to use P6 ( Neiguam ) , patients using a different antiemetic protocol .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2g89x8	Pregabalin to improve the quality of anesthesia care in bariatric surgery	Data analysis completed	Intervention	2017-04-18	<NULL>	<NULL>	1216	Pregabalin to improve the quality of anesthesia care in bariatric surgery : a randomized clinical trial , triple blind , placebo controlled	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Unesp	Hospital Teresa De Lisieux	https://ensaiosclinicos.gov.br/rg/RBR-2g89x8	<NULL>	Patients undergoing open bariatric surgery;Age: 18 to 64anos;Sex  female and male;ASA : P1 ; P2 ; P3	History of allergy to pregabalin; Kidney disease; liver disease; Angle-closure glaucoma diagnosis; History of epilepsy; Patients using monoamine oxidase inhibitors or who have stopped use in the last 14 days.Patients illiterate; unable to sign the consent form. Chronic use of opioids and antidepressants;Allergy to NSAIDS and dipyrone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-33grwq	Therapy to dysphagia in individuals after Stroke	Recruiting	Intervention	2017-04-19	<NULL>	<NULL>	1217	Program of rehabilitation with therapeutic efficacy control in oropharyngeal dysphagia after Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Faculdade Filosofia e Ciências de Marília	Faculdade Filosofia e Ciências de Marília	https://ensaiosclinicos.gov.br/rg/RBR-33grwq	<NULL>	Individuals after stroke; oropharyngeal dysphagia, both genres.	Individuals with cognitive imparment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-4rmyvw	Facial wrinkles teratment	Recruitment completed	Intervention	2017-04-27	<NULL>	<NULL>	1218	Non-invasive treatment of facial wrinkles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4rmyvw	<NULL>	Healthy female volunteers; aged 40 to 60 years; who show signs of facial tissue flaccidity and expression lines with graduation II on the Glogau scale	Allergic reaction to the products used; gestation; Have a metal implant; have orthodontic changes; Have undergone dermatological or dermatological facial treatment previously; Use acids or any anti-aging cosmetics; Have moderate or severe acne (according to the Burton scale) or any dermatitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-7tvv57	The effect of weight loss on the quality of life and balance of obese patients who underwent stomach reduction surgery	Recruiting	Observational	2017-05-02	<NULL>	<NULL>	1219	Influence of weight loss on the mobility, balance and body perception in obese patients submitted to bariatric surgery	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-10-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tvv57	<NULL>	"Group 1 (n = 15): volunteers with grade II obesity (body mass index (BMI) between 35 and 39.9 kg / m²) associated with comorbidities or degree III obesity (BMI ? 40 kg / m²) with or without Comorbid conditions, referred to bariatric gastric bypass surgery (Roux-en-Y gastric bypass gastroplasty).
Group 2 (n = 15): eutrophic volunteers, BMI between 18.5 and 24.9 kg / m²."	Muscle skeletal deformities or dysfunctions that interfere with balance; Neurological dysfunctions; Vestibular problems; Problems with uncorrectable vision with glasses or contact lenses; Use of orthoses for ambulation; Participate in a physical activity program in the last 6 months; Pregnancy; Cognitive problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-8w292w	Efficacy of Fluconazol in the Treatment of Cutaneous Leishmaniasis caused by Leishmania (Viannia) guyanensis in Manaus	Recruitment completed	Intervention	2017-05-03	<NULL>	<NULL>	1220	Effect of fluconazole in the treatment of localized cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis: an open-label, phase two study with sequential dose-escalation groups	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-03-01	Fundação de Medicina Tropical Doutor Heitor Vieira Dourado	Fundação de Amparo à Pesquisa do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8w292w	<NULL>	Male patient with eighteen years of age or more; bearer of American cutaneous leishmaniasis; caused by Leishmanis (Viannia) guyanensis; with up to five lesions; with no more than three months; without any mucosal disease and no previous treatment of the current episode of leishmanisasis	Exclusion criteria are: Refusal to participate in the project; Patients with liver disease; Patients with cardiac arrhythmias; Patients with hypertriglyceridemia; Patients with hypokalemia; recognized hypersensitivity to fluconazole; Presence of immunosuppression	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2nz5s2	Clinical evaluation of coca cola soda exposure after tooth whitening of vital teeth	Recruitment completed	Intervention	2017-05-03	<NULL>	<NULL>	1221	Clinical evaluation of exposure to glue derivatives after tooth whitening of vital teeth	<NULL>	1-2, non-randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2017-01-25	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-2nz5s2	<NULL>	patients aged between 18 and 50; to sign the consent form; good oral health in general; the presence of all the upper and lower front teeth (first premolars, canines and incisors) with vitality; injury-free caries and unsatisfactory restorations; no cervical lesions (abrasion, erosion and abfraction); absence of periodontal disease; non-smoking; initial color of the teeth be A2 or darker	patients undergoing any prior bleaching procedure; pregnant or breastfeeding women; teeth showing staining caused by tetracycline; fluorosis; hyperplasia; endodontic treatment, restorations or prostheses on some of the six upper and lower anterior teeth; receding gums; tooth sensitivity; submit parafunctions;  were on medication that contained heavy metals; analgesics; anti-inflammatory	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-785wvb	Evaluation of the Number of Fragments of Parathyroid Gland Tissue that are Used in Patients Who Have Been Submitted to Total Removal of the Parathyroid Glands in the Treatment of Hyperparathyroidism Due to the Loss of the Renal Function.	Recruiting	Intervention	2017-05-03	<NULL>	<NULL>	1222	Total parathyroidectomy with autotransplantation for secondary hyperparathyroidism: Analysis of the number of parathyroid fragments used in the autograft	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-785wvb	<NULL>	"Patients with end-stage renal kidney disease on hemodialysis; hypercalcemia or hyperphosphatemia;
pruritus; bone pain , bone deformity or fracture, extra-osseus calcification, between 18 and 60 years"	Patients subjected to renal transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-3ypfxv	Effectiveness of Intragastric balloon associated with diet on treatment of patients with type 2 diabetes	Recruitment completed	Intervention	2017-05-04	<NULL>	<NULL>	1223	Evaluation of Intragastric Balloon effectiveness associated to diet on treatment of diabetic patients with BMI&lt;35	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Faculdade de Medicina da Univesidade de São Paulo	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3ypfxv	<NULL>	Volunteers males or females, age between 21 and 59 years; Overweight or obesity grade I (BMI between 27 and 34.9); Non-insulin dependent Diabetes Mellitus, glycated hemoglobin &lt;10%, anti-GAD 65 &lt;10 and peptide C&gt; 1; Previous esophagogastroduodenoscopy with negative Helicobacter pylori research; Approval of psychological and nutritional profile; Clinical / drug and behavioral treatment directed to overweight patients, with no success; Signed informed consent form.	Contraindications to treatment with intragastric, clinical or endoscopic balloon; Impossibility of strict follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-6xts8z	Homeopathy in the discontinuation of inhaled corticosteroid during the treatment of teenagers with perennial asthma	Recruitment completed	Intervention	2017-05-06	<NULL>	<NULL>	1224	Individualized homeopathic medicines vs. placebo for clinical control of perennial asthma in teenagers during the reduction of inhalatory beclometasone:  exploratory, randomized, double-blind, controled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2012-08-05	Universidade Federal de São Paulo	Ambulatório da Criança da Rede Pública de Saúde - Guarulhos/SP	https://ensaiosclinicos.gov.br/rg/RBR-6xts8z	<NULL>	"Subjects with diagnosis of perennial asthma; using inhalatory beclometasone; presenting
dyspnea; and or tightness in the chest; and or cough; and or effort dyspnea; and or other atopic diseases, such as rhinitis, conjunctivitis, dermatitis."	Severe perennial asthma presenting exacerbations  requiring hospital admission or systemic medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-64bhs5	Cardiovascular effects in subjects with pre-hypertension during maximal repetition test	Recruiting	Intervention	2017-05-06	<NULL>	<NULL>	1225	Analysis of systolic blood pressure and autonomic modulation of heart rate in subjects with pre-hypertension during maximal repetition test	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-64bhs5	<NULL>	Adult volunteers; male gender; normotensive or pre-hypertensive according VI SBH Guidelines (2013); without musculoskeletal diseases; do not practice physical exercise within previous 24 hours before the analyzes.	Attendant of private human groups, as indigenous and others; to be anti-hypertensive pharmacological treatment user; to be carrier of musculoskeletal disorders in lower limbs; to be user of alcohol, tobacco, or cofee, as well as non-practitioner of physical activity during last 24 hours before the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2nn9y2	Cutaneous analysis after cells from adipose tissue  applied  in human face	Recruitment completed	Intervention	2017-05-06	<NULL>	<NULL>	1226	Cutaneous analysis after adipose mesenchyimal cells from stromal vascular fraction applied in human face	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2012-08-01	universidade federal do rio de janeiro	universidade federal do rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2nn9y2	<NULL>	20 Healthy patients of both genders, presenting photaged; candidates for facial rejuvenation surgery (face lift); without any clinical procedure in face: laser resurfacing; using PMNA and others;  age rande between  45 and 65 years	"patients with coexisting base disease, such as type II diabetes and other metabolic diseases and autoimmune diseases;
Patients smokers;
 Patients with umbilical hernia;
 Patients with infective dermatitis Local;
 Patients with autoimmune diseases and hematological abnormalities;
 Patients undergoing chemotherapy and / or radiotherapy prior chronic use of corticosteroids and connective tissue diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-9sqr6b	The simulation in the teaching of immunization in nursing graduation	Recruiting	Intervention	2017-05-09	<NULL>	<NULL>	1227	Efficacy of realistic simulation in adult immunization teaching in the context of nursing graduation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-07	Universidade Federal do Rio Grande do Norte - UFRN	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9sqr6b	<NULL>	"Nursing undergraduate students enrolled in curricular components will be included.
Primary Health Care; Have at least 75% attendance during the course offered."	Students who have a frequency of less than 75% in the course offered will be excluded; Those who are not present in the other moments of intervention and application of the research instruments; Fellows and collaborators who contributed to the execution of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2dpc6b	Nursing interventions in decompensated Heart Failure patients	Recruiting	Intervention	2017-05-11	<NULL>	<NULL>	1228	Effect of an advanced nursing program in descompensated Heart Failure inpatients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Programa de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-2dpc6b	<NULL>	Patients of both genders, age from 18 years; Signing of the informed consent form (TCLE); Hospitalized patients with medical diagnosis of decompensated HF independent of etiology.	Patients with cognitive neurological impairment and / or who are already participating in other studies with educational interventions will be considered.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-77y2sp	Effect of acupuncture in the articulation of the jaw and in the energetic balance of the meridians	Recruitment completed	Intervention	2017-05-11	<NULL>	<NULL>	1229	Effect of acupuncture in temporomandibular disorders and energy balance of meridians	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-22	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-77y2sp	<NULL>	Adult volunteers; of both genders; age between 20 and 50 years; with pain due to temporomandibular dysfunction of muscular or mixed origin; with or without mouth opening limitation.	Volunteers with severe trauma or infections in the Temporomandibular Joint; under analgesic and/or anti-inflammatory drugs; pregnant women; fear of needle; under some other type of treatment for temporomandibular joint; edentulous; volunteers using dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2xbpff	Clinical behavior of composite resin restorations silorane-based	Terminated	Intervention	2017-05-12	<NULL>	<NULL>	1230	Clinical behavior of composite resin restorations silorane-based prepared under different surface treatments: randomized controlled longitudinal study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-05	Universidade Estadual de MOntes Claros	Daniela Popoff	https://ensaiosclinicos.gov.br/rg/RBR-2xbpff	<NULL>	Patients over 18 years of age; patients had posterior teeth with indication of class I  on the occlusal face; who agreed to participate in all stages of research; patients with minimal tooth loss.	Patients not able to dental treatment because of its medical history; patients with xerostomia or were taking medication that significantly reduce salivary flow; patients with types of parafunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-7fnbz7	Effects of exercise training on cardiovascular risk factors in HIV patients	Recruiting	Intervention	2017-05-12	<NULL>	<NULL>	1231	Prevalence and effects of aerobic training on cardiovascular risk factors in HIV patients taking antiretrovirals from the metropolitan region of Porto Alegre	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7fnbz7	<NULL>	HIV+ subjects on a stable HAART regimen for at least 3 months before enrollment; he viral load should be less than 50 copies/mL blood and they should not practice any exercise regularly for, at least, six months before to start the training protocol.	Subjects with a previous history of neurological disease; antioxidant supplements, tobacco and/or drug use, physical and/or mental disability and pregnant women were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7yft5y	Ultrasound treatment of gluteal cellulitis in women who use and do not use oral contraceptives	Recruitment completed	Intervention	2017-05-12	<NULL>	<NULL>	1232	Interference of oral contraceptive use in the treatment of Fibro edema geloide with high power ultrasound	<NULL>	n/a, non-randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-17	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7yft5y	<NULL>	Female subjects; Age between 20 and 30 years; Carriers of fibrous integumentary dysfunction; Users of hormonal contraceptive pill for the GA group; And not users of hormonal contraceptive pill for the GN group; without children; That are not undergoing esthetic treatment at the moment.	Individuals with malignant tumors; Infections and acute thrombophlebitis; Plastic osteosynthesis; Areas with altered sensitivity; Pregnant women; With pacemakers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-83cwmx	Development of throw in healthy children	Recruiting	Observational	2017-05-15	<NULL>	<NULL>	1233	Development throw in typical children between 5 and 13 years	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83cwmx	<NULL>	Participants included in the study: no dysfunction has history in the shoulder complex and present shoulder elevation range of motion of at least 150.	Will not be included in the study: participants with a history of rotator cuff surgery, fractures of the clavicle, scapula and humerus, systemic diseases involving the joints, cognitive deficits that prevent understanding commands to carry out the proposed task and injury that primarily affects the plexus brachial or central nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-8z74d2	Training of arms on body alignment individuals with cerebral palsy: a pilot study	Data analysis completed	Intervention	2017-05-15	<NULL>	<NULL>	1234	Impact of upper limb training on body alignment in gait of children and adolescents with spastic hemiparesis-type cerebral palsy: pilot project	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-27	Associação de assistencia a criança deficiente	Associação de assistencia a criança deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8z74d2	<NULL>	"Individuals of both sexes;
Aged between 07-15 years of age;
PC spastic hemiparesis type;
Who were not performing Physiotherapy, Occupational therapy or Physiotherapy aquatic;
They were able to obey simple commands;"	"Clinical instability;
Have undergone some type of orthopedic surgery and neuromuscular blockade for less than six and three months respectively."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5n9g5f	The Vencer Saúde project: study protocol for healthy weight loss with nutritional and exercise training monitoring	Data analysis completed	Intervention	2017-05-17	<NULL>	<NULL>	1235	Healthy weight loss program: nutrition monitoring and physical activity for overweight people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-09	Universidade Federal de Sergipe - UFS	Fundação de Apoio à Pesquisa e Inovação Tecnológica de Sergipe - FAPITEC/SE	https://ensaiosclinicos.gov.br/rg/RBR-5n9g5f	<NULL>	Age between 18 and 59 years; Body mass index of 25 kg/m² to 39.9 kg/m²; weight stable in the last three months; sedentary.	use of drugs for weight loss; eating disorders; osteoarticular diseases; diabetes mellitus; hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-8qjvkd	Effects of race and aquatic physical function in the detraining, muscular strength and body fat in overweight individuals	Recruitment completed	Intervention	2017-05-18	<NULL>	<NULL>	1236	Effects of deep water running and training in functional capacity, muscle resistance and body composition in pre-obese and obese: pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-06	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-8qjvkd	<NULL>	Participants volunteers, of both genders, adults ranging from 39 to 59 years of age, with pre-obesity and obesity I.	Volunteers cardiorespiratory, musculoskeletal and neuromuscular diseases that impede the performance of the aquatic training program, as well as hydrophobia, skin wounds and infectious-contagious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7z858k	Effects of a set of muscle strengthening exercises for upper limbs in individuals with Parkinson&apos;s Disease	Recruitment completed	Intervention	2017-05-19	<NULL>	<NULL>	1237	Effects of a strength training protocol and muscular endurance for upper limbs in individuals with Parkinson&apos;s Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Thais Vianna Corrêa	Escola de Educação Física e Desporto da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7z858k	<NULL>	Clinical diagnosis of idiopathic PD confirmed by Neurologist; Age range between 50-75 years of both sexes; Hoehn &amp; Yahr modified stage between 2-3; Be able to understand and obey verbal commands, obtaining a minimum of 23 points for the Montreal Cognitive Assessment (MoCA)	Have undergone surgical treatment related to PD; To present systolic pressure superior to the 180mmHg and Diastolic superior to the 100mmHg, besides unstable cardiopathy or insufficiency cardiorespiratory; To present impairment of the mental and cognitive state identified by MoCA; To present neurological and / or traumatic-orthopedic affections that compromise the function of the upper limbs and / or spine; Have undergone changes in dose and / or medication after initial evaluation and during training; Have performed an exercise program with Physical Therapy or Physical Education professionals, in addition to sports practice, in the last 3 months before beginning the training; Do not carry out all sessions of the training program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7wyqr7	Evaluation of the local anesthetic ropivacaine versus lidocaine to control pain in lower wisdom extraction.	Recruitment completed	Intervention	2017-05-19	<NULL>	<NULL>	1238	Ropivacaine in its pure formula versus lidocaine for pain control associated to the removal of included lower third molars- a randomized double blind clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-04-10	Faculdade de Ciências da Saúde	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7wyqr7	<NULL>	Lower third molars included with the same classification according to Pearl &amp; Gregory, in the same patient; agree to TCLE; Be patient at the outpatient clinic of Buco Surgery Maxilo Facial of University Hospital of Brasília.	Lower third molars included with different rankings according to Pearl &amp; Gregory, in the same patient; follow guidelines different from those provided by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-2b7kss	Effect of myofascial release in persons with Parkinson&apos;s Disease	Recruiting	Intervention	2017-05-19	<NULL>	<NULL>	1239	Acute effects of myofascial release on cardiorespiratory variables in persons with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2b7kss	<NULL>	Volunteers with clinical diagnosis of Parkinson&apos;s disease; both genders;with scores between 1 and 3 on the Hoehn and Yhar scale.	Volunteers with signs of dementia; cardiorespiratory diseases; neuromuscular diseases; musculoskeletal diseases not related to Parkinson&apos;s disease; to have made changes in the class and/or drug dose between the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-54vnnf	Educational game about breastfeeding for school children of primary school	Data analysis completed	Intervention	2017-05-19	<NULL>	<NULL>	1240	Educational technology about breastfeeding for school children of primary school	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-54vnnf	<NULL>	Children regularly enrolled in the third year of elementary school; attending school during the school calendar in the data collection period; in the age group from seven years; both genders; able to develop activities that include reading words and phrases; understand the guidelines for the development of activities explained by others.	Children who were separated due to illness or those with special needs, identified by the class teacher, that made it difficult to understand questions of the questionnaire and the information of the game, making it impossible to participate in the educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-3y8v57	Estriol use at the entrance and inside of vagina improving coital pain in women after menopause	Not yet recruiting	Intervention	2017-05-12	<NULL>	<NULL>	1241	Use of estriol at distal third of the vaginal wall improving coital pain in women after menopause: a randomized, blinded and controlled trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3y8v57	<NULL>	Women with a clinical diagnosis of menopause; FSH over 40 mIU/ml with a minimum age of 40 years old and and maximum age of 65 with sex including penetration of penis into vagina and complaining of pain during penetration, which appeared in peri or postmenopausal with active sexual partners and stable relationship.	Women will be excluded if previous use of steroids in genital area in the last month; thromboembolism history; renal insufficiency; cholestatic jaundice; degenerative vulvar pathology; breast, endometrial, vulvar and vaginal cancer history; prior radiotherapy to the genital region; smoking; acute urogenital infections (vulvovaginitis, urinary tract infection and genital herpes); genital prolapse grades II, III and IV by Baden Walker; systemic hormonal therapy in the last three months; in treatment of depression; suffering from diabetes, thyroid disorders or cognitive restrictions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5bv8rd	Effect of light therapy (laser) in patients with respiratory disease	Recruiting	Intervention	2017-05-22	<NULL>	<NULL>	1242	Acute effects of photobiomodulation on respiratory variables and functional capacity in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5bv8rd	<NULL>	Volunteers over 18 years of age; diagnosis of COPD with moderate to severe classification; clinically stable; who present symptoms of dyspnea due to small and medium effort.	Alcoholics; volunteers with cardiac pacemaker implantation; neurological disease; acute exacerbations of the disease requiring hospital admission or systemic corticosteroids in the 4 weeks prior to the study; regular exercise (more than 3 times a week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-8y56jt	The use of peripherally inserted central catheter mono e double lumen in neonatal intensive care unit	Data analysis completed	Intervention	2017-05-23	<NULL>	<NULL>	1243	Randomized trial on the use of peripherally inserted central catheter (PICC_ mono and double lumen in neonatal intensive care unit (ICU)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8y56jt	<NULL>	Need of parenteral total nutrition; need of venous catheter for more than six days; use of antibiotics or vasoativ drugs and consent by parents	Use or duration of the PICC for less than 7 days; Use of another central catheter prior to inclusion in the survey; Initial location of the catheter tip in the peripheral region; Transfer of the Intensive Care Unit (ICU) during the period of use of the PICC and parents under the age of 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-33z3x8	"Safety evaluation of cosmetic products by 
gynecologist and dermatologist in normal conditions of use"	Recruitment completed	Intervention	2017-05-25	<NULL>	<NULL>	1244	Gynecological and dermatological aceitabiity evaluation of cosmetics products in normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-26	Avenca Indústria Cosmética	Avenca Indústria Cosmética	https://ensaiosclinicos.gov.br/rg/RBR-33z3x8	<NULL>	Female. Age 18 to 65 years. Phototype I to IV. Intact skin in the test area. Occasional user of the category products.	Cutaneous marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn). Pregnant women or infants. Subjects with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream. Subjects with a history of allergy to cosmetic products of the tested category. Recent gynecological surgeries. Vaginal discharge. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use of corticosteroids in the experimental area up to 8 days before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-3zk3cn	Vital Signs and stress behavior in preterm newborns undergoing to tub bath.	Recruitment completed	Intervention	2017-05-25	<NULL>	<NULL>	1245	Physiological Signs and Behavioral State in Preterms Newborns Undergoing to Two Techniques of Immersion Bath: A Crossover  Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-11	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3zk3cn	<NULL>	"Maximum adjusted gestational age of 36 weeks and 6 full days on the date of data collection;Preterm newborn over 24 hours of life;Spontaneous breathing;Release to immersion bath;No diagnosis of congenital anomalies and heart disease;Newborns no in use of sedative medication;Newborns who are not in the postoperative period;
Clinically stable with heart rate between 120-160 and oxygen saturation greater than 85% whitin 6 hour prior to data collection (immersion bath) and infants fed for at least 1 hour"	Diagnosis of neuropathies and diseases identified after inclusion and data collection or any adverse event as cyanosis or vomiting during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-3wkvcy	The effect of balance training in children´s gait with involvement of one side of the body	Recruiting	Intervention	2017-05-31	<NULL>	<NULL>	1246	The effect of balance training in children´s gait with spastic hemiplegic cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-06	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3wkvcy	<NULL>	Children with cerebral palsy; age between 5 and 15 years; GMFCS 1 or 2; independent walking; sign the TCLE	Bone deformity in lower limbs; use crutches or walkers; surgery for less than a year; do not sign the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-6f497w	Laserterapy and antimicrobial photodinamic therapy on oral mucositis of children: a clinical trial	Recruiting	Intervention	2017-05-31	<NULL>	<NULL>	1247	Randomised clinical trial of antimicrobial photodinamic therapy (aPDT) and low level laser therapy (LLLT) on oral mucositis of pediatric patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-11	Universidade Federal de Pernambuco	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6f497w	<NULL>	Patients from zero to twenty-one years, both genders, diagnosed with malignancies undergoing quimiotherapy;Pediatric patients diagnosed with OM &gt; 1 (WHO);Patients in accordance with the research by signing the informed consent.	Patients  with malignancies in oral cavity; Patients incapable of complying with the treatment; Patients in a serious situation that prevents participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5ckpd3	Effect of pelvic physiotherapy in women with pain during sexual intercourse	Data analysis completed	Intervention	2017-05-26	<NULL>	<NULL>	1248	Effect of pelvic floor muscle training on the sexual function of women with symptoms of dyspareunia: An experimental study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5ckpd3	<NULL>	Sexually active women who had clinical symptoms of dyspareunia	Those who underwent physiotherapeutic intervention for dyspareunia symptoms recently (less than 6 months); Current symptoms of urinary tract infection; And the presence of diseases that constitute contraindications for the accomplishment of the MAP training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-69qk5p	Evaluation of the effectiveness of the use of rifampicin to prevent leprosy in contacts of patients with multibacillary form	Recruiting	Intervention	2017-06-01	<NULL>	<NULL>	1249	Chemoprophylaxis of leprosy with rifampicin in contacts of patients with multibacillary form: a randomized, double-blind, placebo controlled study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto Oswaldo Cruz - Laboratório de Hanseníase	Escola Nacional de Saúde Pública Sérgio Arouca	https://ensaiosclinicos.gov.br/rg/RBR-69qk5p	<NULL>	Contacts of patients with multibacillary leprosy who agreed to undergo chemoprophylaxis; age from 6 months to 70 years; willingness to undergo clinical and anti-PGL-1 evaluation; availability for follow-up; return for vaccination in two months and for clinic evaluation in 12 months.	Clinical or laboratory confirmation of leprosy at baseline; BCG vaccination in the preceding 12 months, except for infants between 6 and 12 months of age; contacts with immunosuppression or history of tuberculosis in all its forms; pregnancy at any stage, or refusal to undergo urine pregnancy test and refusal to sign the  informed consent form (ICF).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-4tf6mr	Cellular application analysis on communication: improvements for teaching in nursing	Data analysis completed	Intervention	2017-06-02	<NULL>	<NULL>	1250	Analysis of a learning object about therapeutic communication: contribution to teaching in nursing	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Estadual do Ceará - Programa de Pós Graduação em Cuidados Clínicos em Enfermagem e Saúde	Faculdade Metropolitana da Grande Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4tf6mr	<NULL>	The student must be attending the discipline of psychological bases for the first time in the undergraduate nursing course and possessing a smartphone.	Students under the age of 18 and those who did not have basic computer skills and use of technology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7vjymj	Length of stay of the dressing after cardiac catheterization by the radial artery: influence on the occurrence of bleeding and vascular complications.	Recruitment completed	Intervention	2017-06-02	<NULL>	<NULL>	1251	Radial artery compression time after coronary angiography: influence on hemostasis and occurrence of vascular complications.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7vjymj	<NULL>	Older than 18 years; submitted to elective coronary angiography by radial access; who agreed to participate in the study, after the knowledge and agreement with the Informed Consent Form	Patients who develop hematoma prior to withdrawal from the introducer; those submitted to percutaneous coronary intervention immediately after elective coronary angiography and hemodynamically unstable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7rw2qq	Comparison of two types of protocols for the construction of dentures	Data analysis completed	Intervention	2017-06-09	<NULL>	<NULL>	1252	Comparison of different methods for making conventional complete dentures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia da Universidade Federal de Goias	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7rw2qq	<NULL>	Fully edentulous, with need of new upper and lower conventional complete dentures	"Patients unable to cooperate;
Patients in poor general health or conditions that could influence their response to treatment such as temporomandibular disorders, orofacial motor disorders, severe oral manifestations of systematic disease or psychological or psychiatric condition"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9y2nn2	Diabetes and exercise	Not yet recruiting	Intervention	2017-03-14	<NULL>	<NULL>	1253	Type 2 diabetes and exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-9y2nn2	<NULL>	Age between 30 and 70 years; body mass index between 25.0 and 39.9 kg/m2; diagnosis of type 2 diabetes for a period equal or greater than 1 year; insufficiently active or sedentary	Clinically unstable Diabetes (change in medication within the last two months); insulin-dependent; history of stroke, neuropathy or advanced retinopathy; pregnant or suspected pregnancy; contraindication for magnetic resonance imaging, according to the list available at: http://www.mrisafety.com/; severe musculoskeletal problems that limit the practice of physical activity; health problems that may interfere with the study protocols or safety during exercise; classified as &quot;risk&quot; for cardiovascular diseases; not submitting medical authorization to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8rtrkh	Effectiveness and sensitivity of home bleaching with hydrogen peroxide with different times of use.	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	1254	Effectiveness and dental sensitivity resulting from the use of 10% hydrogen peroxide in different use protocols - clinical study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-17	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8rtrkh	<NULL>	Patients will be included: 18 years of age or older, with good oral and general health, teeth free of caries lesions, teeth with color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and who agree With the informed consent form (TCLE).	Patients who have undergone dental bleaching, who have dental prostheses or restorations in the upper anterior teeth, who are pregnant or breastfeeding, have gingival retractions, dental sensitivity, endodontic treatment in the upper anterior teeth, severe dental dimming By tetracycline, fluorosis or endodontia), non-carious cervical lesions, fixed orthodontic appliance, habits of bruxism, smoking and visible cracks in the teeth and that are making continuous use of some medication, such as analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9bryw6	Rehabilitation with use of games in patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	1255	Effect of virtual reality therapy on the static and dynamic balance of parkinsonians	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9bryw6	<NULL>	"Both genders;
Age between 18 and 60 years,
Have a clinical diagnosis of Parkinson&apos;s disease;
Participants are able to participate in physical therapy for at least 1 hour, 2 times a week; 
Do not have clinical or self-reported premorbid dementia, severe cardiovascular or musculoskeletal diseases that preclude the practice of physical activity;
Not have been previously submitted to surgery, which requires rest for their complete physical rehabilitation."	"Patients who for any reason do not complete the evaluation protocol; 
Patients who are unable to complete the protocol of physiotherapy sessions because clinical;
Patients leaving the study for other personal or motivational factors."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8swgc3	Inspiratory Mucle Training in Patients after Cardiac Surgery.	Data analysis completed	Intervention	2017-06-13	<NULL>	<NULL>	1256	Inspiratory Muscle Training in Patients Undergoing Cardiac Surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-05	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8swgc3	<NULL>	Patients undergoing cardiac surgery; Both genes; Age between 18 and 80.	"Evolved Death in the peri-operative period;
Evolved With pulmonary complications Or neurological factors that impeded the avaliation; They needed prolonged mechanical ventilation (&gt; 24 hours); They needed Non-invasive mechanical ventilation for more than 4 hours per day."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-6gb83b	Physical Activity and its relationship with factors that affect the quality of life and well being of men diagnosed with Prostate Cancer	Recruitment completed	Intervention	2017-06-14	<NULL>	<NULL>	1257	Physical Activity related to quality of life and associated factors in men diagnosed with Prostate Cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-20	Fundação Universidade do Estado de Santa Cataria	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6gb83b	<NULL>	Patients diagnosed with prostate cancer; age between 50-80 years	Diagnosis of metastasis; practice regular physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-4y8vd2	Acupuncture as another treatment option for women who have Pain in the belly foot and Muscle Pain in the belly that did not improve with the Injection of Anesthetic at the pain site	Data analysis completed	Intervention	2017-06-19	<NULL>	<NULL>	1258	Acupuncture as an alternative method for the treatment of women with Chronic Pelvic Pain and Myofascial Syndrome not-responsive to Topical Injectable Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-11	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-4y8vd2	<NULL>	Women with diagnostic criteria for chronic pelvic pain secondary to abdominal myofascial syndrome; Presence of only one active trigger point on the abdominal wall, have not undergone previous treatment with topical injectable block or acupuncture, age above 18 years and premenopausal, visual analogue scale with a value above 4.4 (moderate pain)	Women with anticoagulation or hemorrhagic disorders, local or systemic infections; Allergy to anesthetics, acute muscle trauma, extreme fear of needles; History of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes; Aspirin intake within 3 days after injection; All patients with suspected endometriosis, interstitial cystitis, irritable bowel syndrome, or other disease that warrants or contributes to chronic pelvic pain; Endometrioma or hernia evidenced by ultrasound of the abdominal wall, infections of the abdominal wall, lack after the beginning of the treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-5p28n4	Effect of Walking and Intensive Exercise on the Health of healthy individuals	Not yet recruiting	Intervention	2017-06-19	<NULL>	<NULL>	1259	Isolated and combined effects of a Physical Exercise Session and Active Behavior on Cardiometabolic Aspects in healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5p28n4	<NULL>	Volunteers with body fat percentage above 25% and 35%, for men and women, respectively; Age between 18 and 35 years; Insufficiently physically active; non smokers.	Voluntary with arterial hypertension; diabetes; In use of medication that influences the cardiovascular system; With bone or muscle limitation for walking or running.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-3v3zmd	Cardiovascular evaluation Exercise in patients with Sjogren&apos;s Syndrome	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1260	Cardiovascular evaluation before and after Resisted and Aerobic Exercise program in patients with Sjogren&apos;s Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3v3zmd	<NULL>	Women with diagnosis of primary Sjogren&apos;s syndrome confirmed by the revised Classification Criteria of 2002; age between 18 and 90 years; understanding and signing of the free and informed consent term.	"Diagnosis of heart, lung, endocrine, or any other disease that impedes the practice of exercise;
Inflammatory joint activity that impedes the practice of exercise; Regular exercise for more than 4 weeks in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-2g9ymm	Analysis of a protocol of whole body vibration in the treatment of celullitis	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1261	Effects of the vibratory platform on the function of pelvic floor muscles and dermatosfunctional dysfunctions in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-2g9ymm	<NULL>	Women; Age from 18 years; Body Mass Index classified as normal or overweight ; Presence of geloid fibroedema in the gluteal region.	Women in dermato-functional body treatment; Women diagnosed with cardiac, neurological and respiratory diseases, diabetes mellitus, systemic arterial hypertension, stone in the kidney or gallbladder, neoplasias and epilepsy; Presence of herniated disc; Use of pacemaker; hip or knee prostheses; Recent pin implants; Plates and screws; Retinal problems; IUD use; Acute inflammation; Acute venous thrombosis; Osteoporosis in advanced stage; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-6pksdp	Abdominoplasty after surgery to reduce stomach and weight loss, may develop a fluid in the abdominal wall (seroma) when leaving a layer of the abdominal wall called fascia.	Recruitment completed	Intervention	2017-06-20	<NULL>	<NULL>	1262	Fascia of Scarpa in the formation of seroma in abdominoplasty after bariatric surgery.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal de Sao Paulo	Universidade Federal de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pksdp	<NULL>	"Patients undergoing gastroplasty who need anchor abdominoplasty 
 Age between 25 and 55 years,
Feminine gender,
BMI less than 30 kg per m²,
Not being nulliparous and at most three pregnancies,
Without restriction as to ethnicity, schooling or social class,
No smoking for at least 2 months"	neoplasia, diabetes mellitus, systemic arterial hypertension diseases of the lymphatic system, and carriers of preexisting abdominal surgery scars, other than those resulting from bariatric surgery, and the Pfannenstiel scar.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-7qrmgd	The effects of horse back therapy in children with cerebral palsy from two to four years old	Recruitment completed	Intervention	2017-06-21	<NULL>	<NULL>	1263	The effects of hippotherapy on function, on postural control and sensory profile in children with cerebral palsy from two to four years old: randomized control trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-7qrmgd	<NULL>	Children in the age range between 2 until 4 years old with diagnosis of Cerebral palsy;presenting medical indication for equotherapy.	Other pathologies or associated syndromes;present structural deformities;have severe cognitive deficits;severe auditory deficit;severe visual deficit;uncontrolled seizures;articular range of insufficient hips;have undergone invasive or surgical procedure 6 months before;have scheduled surgery; have performed equine therapy;participate in other conventional motor therapies and or early stimulation; participate in intensive motor therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-7tysgs	Protocol for the treatment of Urinary Incontinence in women with overweight and obesity through physical therapy and nutritional education	Recruiting	Intervention	2017-06-22	<NULL>	<NULL>	1264	Protocol for the treatment of Urinary Incontinence in women with overweight and obesity through cinesiotherapy and nutritional education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Hospital Universitário Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7tysgs	<NULL>	between the ages of 20 and 65; BMI between 25 and 40 kg/m2; do not have intact hymen; do not perform exercises for the musculature of the pelvic floor; who have signed the Free and Informed Consent Form (TCLE); has not undergone urogynecologic and bariatric surgeries; do not have prolapse of level III or IV; and exhibiting symptoms of urinary incontinence (UI).	(who are unable to understand simple verbal commands or do not follow the guidance provided during the assessment; they that can not contract the PFMs alone, that is, they associate the contraction of the PFM with the accessory muscles: glutes, hip adductors and abdominals, in a visible or palpable way; with presence of vaginal or urinary infection; complain of pain during the evaluation; with more than 20% absences in the intervention period; and decide not to continue the search and / or withdraw their consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-82m4d5	The influence of dance on Parkinson&apos;s disease	Recruitment completed	Intervention	2017-06-23	<NULL>	<NULL>	1265	The influence of dance on Parkinson&apos;s disease and associated factors	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-82m4d5	<NULL>	individuals of both sexes; aged 50 years or more; with a clinical diagnosis of PD according to the criteria of the London Brain Bank; on stable doses of medication; who attending one or two times weekly a physiotherapy section and who have not participated in any dance classes for at least three months.	people, who declare taking part in combined practice of any physical activity program and/or exercise; fail to complete all stages of intervention; are decompensated clinically; do not meet the cut-off points on the Mini Mental State Examination; and with physical disability affecting daily or social life activities, due to other condition than PD.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-65262c	Brief intervention for women who use alcohol	Recruiting	Intervention	2017-06-23	<NULL>	<NULL>	1266	Brief intervention for hazardous and harmful women´s alcohol consumption	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal da Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65262c	<NULL>	Be female; Over 18 years old; Present risk or harmful alcohol consumption patterns; With the availability of attending the service during the necessary period	Visible behavioral changes; Signs of intoxication by psychoactive substances; Not having the Portuguese as their first language; Not have access to a landline or cell phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9g2cpd	Training with weathered exercises associated with photobiomodulation for muscular strength in post-menopausic women	Recruitment completed	Intervention	2017-06-26	<NULL>	<NULL>	1267	Training with weathered exercises associated with photobiomodulation for muscular strength in post-menopausic women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9g2cpd	<NULL>	Women who are postmenopausal for at least one year; who are sedentary in the last six months prior to the study; do not undergo any type of hormone replacement therapy; they must submit a medical report attesting physical fitness to the practice of a resistance training program.	To present uncontrolled diabetes mellitus; neurological deficits; peripheral neuropathies or musculoskeletal impairments that make it impossible to perform the proposed exercises; women who practice frequent physical activity; who have a diagnosis of cancer, fibromyalgia, congestive heart failure, severe arrhythmia, uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9qjr6c	Speech-language Pathology Actions at School	Recruiting	Intervention	2017-06-26	<NULL>	<NULL>	1268	Speech-language pathology actions at school: Phonological awareness, reading and writing skills training in the elementary school	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade de São Paulo - USP	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qjr6c	<NULL>	Students in the first fundamental year; Enrolled in municipal school; Both genders; 5 to 7 years of age.	"Those who did not sign the consent form;
children with visual or hearing disabilities; physical disability; cognitive impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-3tgsqp	Mechanical vibration used in Vibratory Platform after cardiac surgery.	Not yet recruiting	Intervention	2017-06-26	<NULL>	<NULL>	1269	Use of Mechanical Vibration Generated in Oscillating/Vibratory Platform in the Post-Operative Heart Surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-12	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3tgsqp	<NULL>	Patients undergoing cardiac surgery; Both genes; Age between 18 and 80.	"Patients who die in the perioperative period
Patients who develop pulmonary or neurological complications that impede the evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-7s6khg	Preoperative physiotherapy for radical prostatectomy	Data analysis completed	Intervention	2017-06-27	<NULL>	<NULL>	1270	Evaluation of the preoperative Pelvic Physiotherapy in the Urinary Continence of patients submitted to radical retropubic Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Santa Casa de Misericórdia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7s6khg	<NULL>	Patients between 40 and 75 years; Diagnosis of prostate cancer; eligible to radical retropubic prostatectomy at Santa Casa de Porto Alegre; Informed consent; Participate in the initial assessment and willingness to perform two sessions of preoperative pelvic physiotherapy.	Patients with previous pelvic radiotherapy; neurological diseases; previous prostatic transurethral resection; Urinary incontinence; Erectile dysfunction and inability to do pelvic exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9595ds	Educational Video targeted to parents on neonatal Pain relief for newborn Screening Test	Not yet recruiting	Intervention	2017-06-28	<NULL>	<NULL>	1271	Effectiveness of an Instructional Video targeted to parents on neonatal Pain management for newborn Screening Test: a non-randomized, pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-05	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9595ds	<NULL>	Mothers hospitalized in a rooming-in unit; who are fluent in Brazilian Portuguese; with preserved cognitive ability; whose newborns are eligible for neonatal screening, and can be breastfed, positioned on skin-to-skin contact or receive sweet tasting  solution.	Non-compliance in the technique of performing the neonatal screening test (two or than one puncture of calcaneus); blood sample for the neonatal screening collected through peripheral venipuncture or without the mothers&apos; presence; mothers and/or newborns who need hospitalization in another care unit during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-99qqhf	Assessment and rehabilitation of patients with knee pain	Recruiting	Intervention	2017-06-29	<NULL>	<NULL>	1272	Assessment of Patelofemoral Pain Syndrome patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-99qqhf	<NULL>	Pain at least for a month. No relation with accident. Insidious onset. Positive tests for patellofemoral pain. Female. Between 18 and 30 years old.	Specific diseases of the knee. Knee surgery. Knee treatments or physiotherapy during the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-242vw9	Effect of calf muscle strenght control training on balance of elderly women	Recruitment completed	Intervention	2017-06-29	<NULL>	<NULL>	1273	Effect of stability strenght training of plantar flexor muscles in postural sway of elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-242vw9	<NULL>	Feminine gender; Age greater than 60 years; With no history of lower limb injury in the last six months	Musculoskeletal lesion in the lower limbs in the last six months; Vestibulopathy, neuropathy, being in the acute phase of some treatment for lower limbs, neurological problems that interfere in the capacity to carry out the study training and assessment protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-3ht499	Effect of heparin to prevent obstruction of the Hickman® catheter	Recruiting	Intervention	2017-07-03	<NULL>	<NULL>	1274	Effectiveness of heparin solution in preventing Hickman® catheter occlusion: clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-22	Hospital de Clínicas Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3ht499	<NULL>	Being hospitalized in the research unit; Have indication of implantation of Hickman® semi-implantable central venous catheter; Insertion of the Hickman® semi-implantable central venous catheter into the research unit or use of the first Hickman® semi-implantable central venous catheter in the research unit; First hospitalization for transplantation of stem cells in the bone marrow transplantation service in the complex of clinics of the Federal University of Paraná.	Being on anticoagulant by any route of administration; Being in fibrinolytic therapy; Present a history of allergy to heparin components; Bleeding during the period of data collection; Be refractory to platelet transfusion; Have had previous hospitalization in the research unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-7kkd97	Supplementation effect of the milk protein in  women&apos;s health bone  in postmenopausal in a lifestyle modification program with exercise.	Recruiting	Intervention	2017-07-03	<NULL>	<NULL>	1275	Supplementation Effect of Whey Protein in Bone Health Women in Postmenopausal in Modification Program Lifestyle with Exercises Physical and Food Adequacy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-7kkd97	<NULL>	Women; age less than 45; Amenorrhea greater than twelve months; bone densitometry in the last twelve months; bone above (higher) than - 2.4 SD; Availability participate in physical exercise programs of study.	Low bone mass by densitometry below than 2.5 SD negative; serious and neurological disorders; osteo-articular; uncontrolled metabolic; renal failure or creatinine above  1.5 mg by dL and musculoskeletal disease that impede the realization of physical exercise; Use of drugs that interfere with bone metabolism (estrogen, testosterone, bisphosphonates, raloxifene, calcitonin, fluorida, corticosteroids and calcium) antireabsortivo and anticonvulsants; History of malignancy; bone fracture occurred in the last six month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-47tvky	Effects of metformin on brown fat of patientes with Polycystic Ovary Syndrome	Recruiting	Intervention	2017-07-04	<NULL>	<NULL>	1276	Effects of metformin on levels irisin and distribution of brown fat in women with Polycystic Ovary Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-47tvky	<NULL>	Premenopausal women diagnosed with polycystic ovary syndrome using the Rotterdam criteria (2003)	Use of antiandrogen medication in the last six months or hormones, including hormonal contraceptives, or metformin in the last two months. Obesity grade II or higher, defined as body mass index greater than 35 kg / m2. Pregnancy, postpartum and lactation. Diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8tbhyr	Effect of Treadmill Training on Treadmill and Video Game on the Balance and Walking of People with Parkinson&apos;s Disease	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1277	Effect of gait training and virtual reality on balance and gait in individuals with Parkinson’s disease: Protocol for a randomized, controlled, blind, clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-8tbhyr	<NULL>	Diagnosis of idiopathic PD in phase 1, 2 or 3 on the Hoehn and Yahr scale; Score ? 46 on Berg Balance Scale – BBS; Adequate vision (with or without glasses);  Adequate hearing (with or without a hearing aid).	Physical disability; Severe heart disease; History of seizure; Uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8qhcys	The influence of robot-assisted gait training on stroke survivors with ataxia	Data analysis completed	Intervention	2017-07-05	<NULL>	<NULL>	1278	The influence of robot-assisted gait training on Stroke survivors with ataxia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-23	UNIFESP- Universidade Federal do Estado de São Paulo	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8qhcys	<NULL>	"Stroke survivors with ataxia. Minimum time of injury over 1 year. Clinical stability. Presence of hemiplegia or quadriplegia motor impairment.
Both genders and who were at least 18 years of age were accepted and 80 years maximum. A physician examined all the patients and described their diagnosis in medical records."	"Physical disability that made training with the robotic device unsafe such as cognitive impairment. Dementia. Aphasia. Presence of other orthopedic or neurosurgical problems in the lower extremities. Pressure ulcers on the hips or lower extremities. Weight higher than 120 kg.
Ataxia originated by progressive disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8kzvsk	Effectiveness of Ocular Physiotherapy versus Home Exercises in the Convergence Insufficiency	Not yet recruiting	Intervention	2017-07-05	<NULL>	<NULL>	1279	Effectiveness of Ophthalmic Physiotherapy versus Home Exercises in the Convergence Insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-03	Faculdade Assis Gurgacz - FAG	Faculdade Assis Gurgacz - FAG	https://ensaiosclinicos.gov.br/rg/RBR-8kzvsk	<NULL>	"Age above 18 years old;
Convergence insuffiency symptons superior 11 from CISS (Convergence Insufficiency Symptom Survey)."	"Neurological diseases;
Ocular diseases under treatment;
Cognitive and behavioral changes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8cbxrq	Water- walking for Parkinson&apos;s.	Recruitment completed	Intervention	2017-07-05	<NULL>	<NULL>	1280	Parkinson disease and physical exercise	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8cbxrq	<NULL>	Inclusion criteria comprised subjects with Parkinson disease, presenting no cardiopathology, and in agreement with the consenting legal terms.	Those who do not accomplish at leats 85% of the exercise program will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-96xzyf	Unilateral Hearing Loss: benefit of the use of the hearing aid in the abilities of sound localization and ordering and temporal resolution	Data analysis completed	Intervention	2017-07-06	<NULL>	<NULL>	1281	Unilateral hearing loss: benefit of amplification in the ordering and temporal resolution and sound localization	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade de São Paulo	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-96xzyf	<NULL>	Volunteers from 18 to 60 years; both genders; with unilateral sensorineural or mixed acquired hearing loss; no experience with individual sound amplification apparatus; with indication of the device complying with the SAS / MS 587 Directive.	Neurological alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8wfjw9	The effect of flat and textured insoles on the balance of community elderly people	Data analysis completed	Intervention	2017-05-09	<NULL>	<NULL>	1282	Effect of textured and flat insoles on the balance of community elderly people: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-07	Faculdade de Ciências Médicas	Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-8wfjw9	<NULL>	"Elderly aged 65 or older
Able to read and answer the proposed questionnaires"	Reduced Tactile or Thermal sensitivity; lower limbs&apos; cutaneous integrity compromitted; Vestibular disease;Patologies evolving Central Nervous System disorders: Parkinson, Strokes and Diagnosed concomitant dementias; Lower limbs Neuropathies; Use of insoles less than 30 days before the research; Previous Feet surgery; Lower limbs amputation;use of benzodiazepines or tricyclic antidepressants Impossibility to attend the necessary reassessments; Inability to follow directions and collaborate with study protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5njnqt	The effect of Circuit Strength Training In Combination With Interval Exercise on sympathetic and parasympathetic systems in Sedentary Subjects	Suspended	Intervention	2017-07-10	<NULL>	<NULL>	1283	Influence of Strength Training In Circuit Combined To Interval Exercise on modulation of the autonomic nervous system in Individuals With Sedentary Behavior	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Federal de Mato Grosso do Sul	Universidade Anhanguera Uniderp	https://ensaiosclinicos.gov.br/rg/RBR-5njnqt	<NULL>	Healthy volunteers; both genders; adult; with at least six months of professional experience as government employee on activity, persisting on sitting position during at least four hours per worked day	Volunteers with history of orthopaedic trauma or musculoskeletal surgeries; withdrawal or desire not to participate in the clinical evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-86yn4b	Effects of telephone use to promote the health of people living with HIV/AIDS	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1284	Effects of a telephone follow-up program to promote the health of people living with HIV/aids	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-86yn4b	<NULL>	Adults being treated for HIV; Both genders;age between 18 and 59 years.	Diminished visual acuity; dysarthria; accused; Mental disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9mmhnw	Effects of different Post-Effort Methods on Muscle Strength and Heart Rate Variability in diverse Sports Practitioners	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1285	Influence of different therapeutic interventions of Post-Exercise Recovery on Muscle Performance and Cardiac Autonomic Modulation in practitioners of different Sports Modalities	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9mmhnw	<NULL>	Adult volunteers; practitioners of judo, handball, basketball, volleyball or indoor soccer.	Volunteers having presented sport practice history lower than one year; presence of sport injuries; physical treatment with medicines having affected the cardiac autonomic activity; presence of inflammatory processes, infections, metabolic or cardiorespiratory diseases; presence of Raynaud Syndrome or cold allergy; practice of exercise within last 24 hours previous to the investigation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9fxqs2	Effects on the muscles after the use of the vaginal dilator in pregnant	Data analysis completed	Intervention	2017-07-10	<NULL>	<NULL>	1286	Muscle responses after the physiotherapeutic intervention with the use of the vaginal dilator in pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fxqs2	<NULL>	"Age between 18 and 35 years;
Gestational age of 34 weeks;
Primparas;
Physiological gestation;
With medical authorization to perform the physiotherapeutic intervention."	"Multiple gestation;
Presence of high gestational risk;
Presence of bone deformities;
Presence of important muscular dysfunctions;
Unusual fetal position or risks that make vaginal delivery impossible (placenta previa);
Presence of risk of ascending infection such as vaginal infection (such as premature amniorrhexis, vaginal infection);
Presence of unhealed lesions in the vaginal region;
Be visibly under the influence of drugs or alcohol;
Presence of vaginal bleeding;
Presence of cervical cancer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5j38t9	"Safety evaluation of cosmetic products by 
gynecologist and dermatologist in normal conditions of use"	Recruitment completed	Intervention	2017-07-11	<NULL>	<NULL>	1287	Gynecological and dermatological aceitabiity evaluation of cosmetics products in normal conditions of use	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-31	Ipclin - Pesquisa Clínica Integrada	SF Indústria Plástica Limitada	https://ensaiosclinicos.gov.br/rg/RBR-5j38t9	<NULL>	Female. Age 18 to 65 years. Phototype I to IV. Intact skin in the test area. Occasional user of the category products	Cutaneous marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn). Pregnant women or infants. Subjects with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream. Subjects with a history of allergy to cosmetic products of the tested category. Recent gynecological surgeries. Vaginal discharge. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use of corticosteroids in the experimental area up to 8 days before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9vmjs4	Comparison of effects occurring in the spine at the end of the Pilates Method session after balloon massage and after performing exercises on the wall	Recruitment completed	Intervention	2017-07-12	<NULL>	<NULL>	1288	Comparison of the immediate effects on the angles of the thoracic and lumbar curvatures produced by mobilization of soft tissues through massage balls and the execution of wall exercises at the end of the Pilates Method session	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-17	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9vmjs4	<NULL>	Healthy women; Age between 25 and 65 years; Pilates practitioners at the Alinhar Clinic in Pelotas or the Pilates Space Clinic in Uruguaiana; Individuals who have attended Pilates sessions for at least three months.	Pain above grade 7 according to the Verbal Numerical Scale; Presence of gibbosity in the Adams test; Pregnant; Skin rashes that prevent the completion of the massage at the end of the Pilates Method session due to pain or sensitivity on the spot.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3rjby9	Gum treatment associated with application of simvastatin gel in patients with high levels os cholesterol	Recruiting	Intervention	2017-07-12	<NULL>	<NULL>	1289	Effect of non-surgical periodontal treatment associated with 1.2% simvastatin locally delivered in patients with chronic periodontitis and hyperlipidemia	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2017-06-15	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3rjby9	<NULL>	Man and women between 30 to 60 years of age; Availability to participate in all study phases; Good general health; At least 10 natural teeth, except for the third molars; Diagnosis of severe periodontitis according to Eke et al. (2012), which is at least one interproximal site with probing depth &gt;5mm and clinical attachment loss &gt;6mm in at least two interproximal sites and in different teeth; At baseline, report the use of any statin for at least 3 months;	Presence of orthodontic bands any type of fixed orthodontic appliance; Tumor (s) of soft or hard tissues of the oral cavity; Use of antibiotics 3 months prior to study begging; Pregnant or lactating women; Diagnosis or treatment for diabetes and renal chronic diseases, or any history of stroke; Need to use antimicrobial chemoprophylaxis to receive dental treatment; Had received periodontal treatment in the last 6 months; Current smokers or former smokers in less than 2 years; Body mass index &gt;30 kg/m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8sw24r	"Evaluation of a Restoarative Cement recommended for Atraumatic Restorative Treatment (ART) and a Composite resin in primary molars: 
Clinical Trial"	Recruitment completed	Intervention	2017-07-12	<NULL>	<NULL>	1290	"Evaluation of a Glass Ionomer Cement recommended for ART and a Nanofilled Composite resin in primary molars: 
Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-23	Centro de Pesquisas Odontológicas São Leopoldo Mandic	Centro de Pesquisas Odontológicas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-8sw24r	<NULL>	age between 7 and 10 years old;presence of occlusal-proximal cavities in deciduous molars with isthmus between 1 and 3.0 mm and a depth less than 2.5 mm at the deepest point of the cavity.	deficient restorations;pulp exposure;pain;history of fistula;tooth mobility;cavities smaller than 1mm and proximal atypical cavities (larger than 3mm) and deeper than 2.5mm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5twbsm	Effect of transcutaneous nerve electrostimulation (TENS) during bodybuilding exercise in the control of pain and physical performance of healthy adults	Recruitment completed	Intervention	2017-07-12	<NULL>	<NULL>	1291	"Effect of transcutaneous nerve electrostimulation (TENS) during exercise
In the control of pain and in the physical performance of healthy individuals"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5twbsm	<NULL>	The sample will consist of healthy; university students; of both sexes; aged 18 and 40; who will be recruited on São Cristóvão campus of Federal University of Sergipe; through personal contacts with them on campus facilities and dissemination by email; irregularly active; and have not performed resistance training of the muscles of the upper limbs for two months prior to the survey. The short version of the international physical activity questionnaire (IPAQ), validated in portuguese, will be used to ensure the eligibility of the sample.	They have any musculoskeletal, cardiovascular, neurological or systemic disorder that can be exacerbated by strenuous exercise (eg, recent injury; chronic pain; heart disease). Potential medical contraindications for the study of exercise protocol will be further evaluated using a questionnaire prepared by the author, based on the physical activity readiness questionnaire (PAR-Q, 2011). The subjects who have had some experience with TENS or any contraindication to prevent the use of electrical stimulation, such as allergy to the material of the electrodes; cardiac pacemaker use; pregnancy; epilepsy; altered skin conditions or loss of feeling in areas established for electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9y472p	The impact of physical exercise on sexuality and religiosity of people with chronic respiratory disease	Recruitment completed	Intervention	2017-07-13	<NULL>	<NULL>	1292	The impact of pulmonary rehabilitation on sexuality and religiosity of patients with chronic obstructive pulmonary disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Ceará	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9y472p	<NULL>	Patients for both gender with clinical diagnosis of COPD with moderate to very severe airflow obstruction presenting spirometric values of forced expiratory volume in the first second between 30 and 80% of predicted according to GOLD: Age between 18 and 80 years; Clinically stable (absence of hospitalization episode or infection in the 3 months prior to the study);	Patients who presented any other associated chronic respiratory disease requiring urgent treatment or intervention;Presence of other non-pulmonary diseases considered incapacitating, severe or difficult to control; Patients who did not complete the study protocol and / or those who had an episode of exacerbation during the period that included their participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5td5hg	Influence of Bleaching Gel storage temperature on Color stability and Dental Sensitivity	Data analysis completed	Intervention	2017-07-17	<NULL>	<NULL>	1293	Influence of Bleaching Gel storage temperature on Color stability and Dental Sensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	CESCAGE - Centro de Ensino Superior dos Campos Gerais	CESCAGE - Centro de Ensino Superior dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5td5hg	<NULL>	Healthy volunteers; Both genders; Age between 18 and 40 years, with upper and lower anterior teeth with vitality; Adequate oral hygiene; With central incisors that should be A2 or darker in color according to the Vita scale (VITA classical, VITA Zahnfabrik, Bad Säckingen, Germany)	Voluntary smokers; Pregnant and lactating women; Patients with teeth showing staining caused by tetracycline; Fluorosis; Hyperplasia; endodontic treatment; Presence of restorations in the eight upper and lower anterior teeth; Previous dental sensitivity; Parafunctional habits; Cervical lesions (abrasion, erosion and abfraction), periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3r6pc2	Cognitive stimulation therapy for elderly with cognitive and functional complaints: Brazilian adaptation and validation	Recruiting	Intervention	2017-07-17	<NULL>	<NULL>	1294	Cognitive stimulation therapy for Dementia: Brazilian adaptation and validation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Pontifícia Universidade Católica do Rio de Janeiro	Pontifícia Universidade Católica do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3r6pc2	<NULL>	Age over 60 years; Both genders; People diagnosed with dementia; Score between 10 and 24 on the Mini Mental State Exam; Be able to answer neuropsychological evaluation.	Age greater than 95 years. Mental retardation previously diagnosed according to ICD criteria 10.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-8287pp	Calcium hydroxide as a root canal treatment material to anterior primary teeth.	Recruitment completed	Intervention	2017-07-18	<NULL>	<NULL>	1295	Calcium hydroxide as a filler material in pulpectomies of anterior primary teeth - Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-13	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8287pp	<NULL>	Upper anterior primary teeth; Radiographic alteration suggestive of periapical lesion; Cavity that allows restorative recovery; Without any previous pulp treatment; Good systemic health.	Root resorption with more than 2/3; Radiographic rupture of the pericoronary sac of the permanent successor; Syndromes; Systemic changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3sst2s	Electrical stimulation in cirrhotic in peripheral muscle strength and exercise capacity	Recruiting	Intervention	2017-07-18	<NULL>	<NULL>	1296	Neuromuscular electrical stimulation in cirrhotic in peripheral muscle strength and exercise capacity: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Fundação Universidade do Estado de Santa Catarina	Fundação Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3sst2s	<NULL>	Diagnosis Liver cirrhosis, Child-Pugh B and C;  stable and under medical supervision ; patients without : uncontrolled hypertension, recent ischemic heart disease ( 3 months or less ) , unstable angina and severe cardiac arrhythmias ; no evidence of gastrointestinal bleeding , encephalopathy , acute pancreatitis or spontaneous bacterial peritonitis ; patients with absence of respiratory diseases , orthopedic diseases and limiting neurological diseases for electrostimulation and protocol ; patients who do not undertake any form of physical training or who have been held for more than 6 months .	Failure to perform any of the study assessments ( lack of understanding or cooperation ) ; deterioration of the clinical picture during the search ; clinical complications of cardiorespiratory nature and / or musculoskeletal during the survey period;  patients with Hepatopulmonary syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-4z4f48	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	1297	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina da Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-4z4f48	<NULL>	Seniors will be selected aged 60-80 years; of both genders; which did not show neurological and orthopedic disorders that promote disability of the elderly remain in bipedalism and wade unaided or cardiovascular disease uncompensated such as: angina; heart failure; high blood pressure decompensated; show no signs of cognitive impairment; the normal or corrected visual acuity measured by Snellen chart; normal or corrected hearing is clinically assessed by the whisper of the test; who did not have previous experience with the Kinect system and accepting to participate by signing the Informed Consent and Informed.	The elderly will be excluded that during the study period submit any clinical change that makes it impossible to perform physical exercises in standing position as: cardiorespiratory; orthopedic or neurological disorders; seniors who are missing for more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-2hpkp3	Effect of vaginal contraction exercise in bladder control in women with multiple sclerosis and neurological disease caused by the virus HTLV1	Recruiting	Intervention	2017-07-19	<NULL>	<NULL>	1298	Pelvic floor training in the treatment of lower urinary tract symptoms in women with Multiple Sclerosis (MS) and HLTV-I associated Myelopathy (HAM / TSP): A randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2hpkp3	<NULL>	"Women with diagnosis defined in Multiple Sclerosis, in the relapsing remitting form
And with the disease stabilized for at least four months, EDSS score less than or equal to 6.5. Or women with a diagnosis defined in HAM / TSP, with more than 18 years of age with HTLV - 1 positive ELISA and confirmed by Western blot (HTLV Blot 2.4), with urological and neurological evaluation, Osame Motor Scale dysfunction OMSS) and score in the lower EDSS equal to 6.5.
Aged over 18years, cognitive ability to respond to evaluation questionnaires and treatment protocol, presenting symptoms of urinary dysfunction for at least six months (at least three of the following: urgency,
Urge incontinence, high voiding frequency, nocturia and nocturnal enuresis), with no history of previous treatment with pelvic floor exercises, those that will not present genital prolapses
Or history of previous gynecological surgeries that are not pregnant, with no history of vaginal delivery or cesarean section within a period of less than six months prior to the start of the study, as well as those who will be out of menopause and without urinary infection excluded by laboratory examination."	Pregnant women with Diabetes mellitus, indigenous ethnicity and or quilombola, under the age of 18. Women who present exacerbation of symptoms or outbreak during the course of treatment, those who can not attend the treatment and refuse to perform the proposed treatment or voluntarily give up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3br7jc	Massage and Aromatherapy for treatment of Low back Pain and Quality of life improvement	Data analysis completed	Intervention	2017-07-19	<NULL>	<NULL>	1299	Applicability of Complementary Practices to reduce Pain, Stress, Anxiety and improvement of Quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-3br7jc	<NULL>	Pain greater than or equal to 5 in the Visual Analogue Scale; nonspecific low back pain for more than 3 months; age between 20 and 55 years; both genders	Spondylolisthesis; disc herniation; use of anti-inflammatories or analgesics; open areas such as wounds or burns; skin cancer; severe infections; extensive edema;pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-9x957k	Activity of the shoulder muscles during the development of the throw with speed and accuracy	Recruitment completed	Intervention	2017-07-19	<NULL>	<NULL>	1300	Electromyographic activity of the shoulder muscles during the development of the throw with speed and accuracy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9x957k	<NULL>	Participants who do not have dysfunction history in the shoulder complex; present shoulder elevation range of motion of at least 150 degrees.	history of rotator cuff surgery, fractures of the clavicle, scapula and humerus, systemic diseases involving the joints, cognitive deficits that prevent understanding of commands to perform the task, injury that affects the brachial plexus or the system central nervous and the presence of developmental delay according to the account of the parents;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3bs2g4	Evaluation of patients with pain in the muscles of the face and ear after light therapy associated or not with the Occlusal Plaque	Recruitment completed	Intervention	2017-07-20	<NULL>	<NULL>	1301	Orofacial assessment of individuals with Temporomandibular Dysfunction after LED therapy associated or not with Occlusal Plaque: a randomized double-blind controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade do Vale do Paraíba - UNIVAP	Universidade do Vale do Paraíba - UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-3bs2g4	<NULL>	Volunteers of both genders; Age between 18 and 45 years; Diagnosed with temporomandibular joint disorders of myogenic origin; Who present chronic pain status (duration of pain not less than 3 months).	Volunteers who present with systemic diseases (Diabetes, Hypertension, cardiopathies and etc), Displacement of the articular disc; Volunteers in orthodontic and / or orthopedic treatment; Volunteers who make continuous use of systemic or topical medications, such as: photosensitive medications, sedatives, muscle relaxants, analgesics, corticosteroids or anti-inflammatory agents	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-5mgv4k	Treatment of Temporomandibular Joint Problems with Laser Therapy and Occlusal Splint	Recruiting	Intervention	2017-07-20	<NULL>	<NULL>	1302	Treatment of Temporomandibular Disorder with Laser Therapy and Occlusal Splint: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5mgv4k	<NULL>	Patients diagnosed with temporomandibular disorder; myofascial pain by the Research Diagnostic Criteria (RDC)	Pregnancy; clinical conditions of muscle spasm; myositis; contracture; polyarthritis; acute traumatic injuries; disc displacement without reduction; total or partial edentulous patients that include the anterior region; treatment with another health professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-299d6k	Exercise effect on human intestinal bacteria	Recruiting	Intervention	2017-07-23	<NULL>	<NULL>	1303	Exercise effect on human gut microbiota: an exploratory study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-24	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-299d6k	<NULL>	Young adults (18 and 35 years old); sedentary for at least six months; BMI between 18.5 and 29.9kg/m²	Those who ingested any antibiotics in the last three months; if they are vegan vegetarians or are following some kind of restrictive diet; if they have intolerance or allergy to any food; presence of chronic or acute diseases of the gastrointestinal tract and/or other chronic disease, such as dibetes or arterial hypertension; presenting disability and/or any other clinical complications that prevent the practice of physical exercise. Besides that, the lack of availability to participate in our training schedule and collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-9tkt8z	Auriculoterapia e Massagem for Neck Pain and  Quality of life improvement	Data analysis completed	Intervention	2017-07-24	<NULL>	<NULL>	1304	Applicability of the Auriculotherapy and Massage to reduce Pain, Stress, Anxiety and Quality of life improvement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-9tkt8z	<NULL>	Pain score equal or greater than 5 by the Visual Analogue Scale; age between 20 and 55 years	"Paresthesia; decreased strength; anti-inflammatory drugs; analgesics and muscle relaxants; cervical spine surgeries;
inflammation and or infection in treated regions;tissue damage in the external ear or cervical and thoracic region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3pw3hd	Strength training for elderly women	Data analysis completed	Intervention	2017-07-24	<NULL>	<NULL>	1305	Effect of a Strength-Training Program with Self-Selected and Prescribed Intensity on Adherence, Psychophysiological Responses, Functional Capacity, Quality of Life and Body Composition in Sedentary Elderly Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-3pw3hd	<NULL>	Woman; age between 60 and 70 years; body mass index between 18.5 and 30 kg/m2; insufficiently active	Signs and symptoms of cardiovascular, respiratory, metabolic or renal diseases; severe musculoskeletal problems that limit the practice of physical activity; not presenting medical authorization; positive response in any item in the Physical Activity Readiness Questionnaire (PAR-Q); ex-smoker or smoking status	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-27p6qf	Pilates effect on sexuality, self-esteem and the quality of life of women who had Breast Cancer and survived	Recruiting	Intervention	2017-07-24	<NULL>	<NULL>	1306	Effect of Pilates exercise method  in sexuality, self-esteem and quality of life of women survivors of Breast Cancer: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-29	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-27p6qf	<NULL>	Female volunteers; Age between 35 and 65 years, non-smokers; survivors of the treatment of malignant neoplasm of the breast.	Volunteers with neurological comorbidities; Limiting deficiency; Cancer recurrence or metastasis; Latex allergy; That are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-73tqdf	Study of infection zika virus in pregnancy and infants	Recruiting	Observational	2017-07-26	<NULL>	<NULL>	1307	International prospective observational cohort study of zika in infants and pregnancy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Fundação Oswaldo Cruz	National Institutes of Health	https://ensaiosclinicos.gov.br/rg/RBR-73tqdf	<NULL>	"PREGNANCY
Consent;
Older than 15 years;
Authorization and consent provided by local law;
Pregnancy confirm by measuring beta hCG blood / urine or through fetal heartbeat on ultrasound exam;
Proof that the participant is in first trimester of pregnancy (between 4 and 12 weeks) by gestational calculator or fetal ultrasound; 

NEWBORN
All children born to women enrolled in the observational cohort are eligible for the study"	"PREGNANCY
Women who can´t join the proposed protocol program;
Pregnant women enrolled in other studies , including other research ZIKV;

NEWBORN
If the legal representant of the child doesn´t consent to the child to participate to the study;
Babies born to mothers who aren´t partipate of the ZIP cohort study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-6bjfd5	Effects of Electrical Stimulation and leg Movement with Stationary Cycling in ICU and infirmary patients	Recruiting	Intervention	2017-07-26	<NULL>	<NULL>	1308	Effects of Electrostimulation associated with Active Movement of the lower limbs with Cycloergometro in patients admitted to the intensive care unit and infirmary of the Santa Casa de Alfenas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-08	Universidade Federal de Alfenas - UNIFAL MG	Universidade Federal de Alfenas - UNIFAL MG	https://ensaiosclinicos.gov.br/rg/RBR-6bjfd5	<NULL>	Patients with hospitalization period of at least two days; age between 18 and 50 years; both sexes, sensitivity and cognitive preserved; Glasgow Coma Scale 15; hemodynamically stable; adequate pulmonary gas exchange; Inspired fraction of oxygen less than or equal to 60% and positive pressure at the end of the expiration less than or equal to 10 cmH2O with peripheral oxygen saturation greater than 88%; Sign the Free and Informed Consent Form.	Pregnant patients; change in sensitivity; cognitive alteration; shocks; renal support; thrombocytopenia; deep vein thrombosis; agitation and confusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-8pbjf5	Efficacy of surgical laser during orthognathic surgeries	Recruitment completed	Intervention	2017-07-26	<NULL>	<NULL>	1309	Efficacy and safety of diode laser during circumvestibular incision for Le Fort I osteotomy during orthognathic surgeries: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Minas Gerais	Hospital da Baleia	https://ensaiosclinicos.gov.br/rg/RBR-8pbjf5	<NULL>	Both genders with dentofacial deformities, aged 18 years or older, who have indication of orthognathic surgery	Will be excluded from the study patients using analgesics or anti-inflammatories; syndromic; immunosuppressed; diabetic patients with coagulopathies; uncontrolled hypertensive patients and patients with a history of trauma or previous surgery involving the upper lip. These clinical conditions will be determined through anamnesis and laboratory tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-6th7rt	Clinical evaluation of different delivery methods of At-home bleaching with 10% Hydrogen Peroxide	Data analysis completed	Intervention	2017-07-26	<NULL>	<NULL>	1310	Sensitivity and Genotoxicity assessment in adolescents submitted to Bleaching with Strips or Trays	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UFAM - Universidade Federal do Amazonas	UFAM - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6th7rt	<NULL>	Volunteers had between 15 and 20 years; at least one central incisor or canine with A2 or darker color; six upper anterior teeth restorations-free on the buccal surface.	Volunteers with systemic diseases (metabolic, immunological and cardiopathies); periodontal disease; enamel showing changes; volunteers with braces; severe crowding; presence of intrinsic stains; use of anti-inflammatory drugs; smoking; drinking; in pregnancy or lactation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-6d9657	Comparison of the results of two different types of acids on the face of women with oily and blemished skin.	Recruiting	Intervention	2017-07-28	<NULL>	<NULL>	1311	Comparison of effectiveness of chemical peeling of retinoic acid and mandellic acid on oleosity and acne hypercromy in adult women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-25	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6d9657	<NULL>	Will be included female individuals, aged between 18 years and 48 years, with a phototype of I to IV and with complaint of hyperchromia after acne on the face verified by Baumman questionnaire	Pregnant and lactating women will be excluded who have is subjected to dermatological and / or cosmetic treatment in the face in the last 6 months, or who have active infection in the face (acne&gt; grade I), disease dermatological or metabolic causing hyperpigmentation of the face, such as Syndrome Cushing&apos;s and Lupus Systemic Eritrematoso or hyperpigmentation from birth as nevus. Similarly, those who miss session 01 any of the groups are excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5tdhzy	Nutritional intervention to reduce the consumption of oils and fats	Recruitment completed	Intervention	2017-08-01	<NULL>	<NULL>	1312	Development and evaluation of nutritional interventions in the academia da cidade Program belonging to the BH Saúde Project - Belo Horizonte-MG	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-09	Universidade Federal de Minas Gerais - UFMG	Secretaria Municipal de Saúde de Belo Horizonte -SMSBH	https://ensaiosclinicos.gov.br/rg/RBR-5tdhzy	<NULL>	Volunteers who did not participate in any nutritional intervention to reduce the consumption of oils and fats; In the activities of the academia de cidade program	Volunteers under 20 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5xh3ch	Effects of an elastic tape on the activity, strength and muscular endurance of subjects with low back pain	Recruitment completed	Intervention	2017-08-02	<NULL>	<NULL>	1313	Effects of kinesio taping on electromyographic activity, muscle strength and endurance in subjects with low back pain: a clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-10	Universidade Estadual de Goiás	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5xh3ch	<NULL>	Age between 18 and 45 years; presence of chronic nonspecific low back pain (low back pain with no specific cause lasting more than 3 months) and authorization of evaluation; procedures through the Free and Informed Consent Form in accordance with resolution 466/12 Of the National Health Council.	History of allergy to the tape (allergy test; episode of exacerbation (pain intensity greater than 05 points on the Visual Analogue Pain Scale (VAS);moderate or severe functional disability according to the Rolland Morris Disability Questionnaire on the days of assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4xr92k	Effectiveness of Magnesium Sulphate for General Anesthesia in Adults	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1314	Effectiveness of magnesium sulphate compared to rocuronium for rapid sequence orotracheal intubation in adult patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Centro Universitário Tiradentes	Centro Universitário Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-4xr92k	<NULL>	Patient diagnosed with acute appendicitis; Physical status ASA I and II; Age between 18 and 70 years.	Pregnancy; Neuromuscular disease; renal insufficiency; Body mass index greater than 30 km.m-2; Anticipation of difficulty in handling the airway; Chronic use of calcium channel blockers; Chronic use of medicines containing magnesium; Past allergy to magnesium sulfate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4cmxry	Effects of Osteopathic and strength exercise in Resistance, Muscular Strength and Speed Blood  of Cardiac Patients.	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1315	Effects of Treatment Osteopathic Manipulative (TMO) and resistance exercise circuit (REC) in cardiorespiratory capacity, Muscular Performance and Blood Flow of Patients with Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-17	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	https://ensaiosclinicos.gov.br/rg/RBR-4cmxry	<NULL>	Diagnosis of heart failure documented in the last 6 months; left ventricular systolic dysfunction &lt;35 % demonstrated by echocardiography; New York Heart Association classification ( NYHA ) class II and III and without participation in aerobic or resistance training programs in the last three months before the study protocol.	Individual previously diagnosed with moderate or severe chronic obstructive pulmonary disease; recent heart surgery in the last 3 months); morbid obesity; peripheral vascular disease and person who is not able to perform the exercise protocol resisted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-3ndqws	Effect of a caries paralyzing substance on deep cavities of milk molars compared to a caries obturator treatment	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1316	Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3ndqws	<NULL>	Children aged 2 to 5 years;who are in good general health;who have at least one active dentin carious lesion on the occlusal surface of primary molars corresponding to ICDAS codes 5 or 6.	Children with systemic or neurological diseases;whose families intend to move from Rio de Janeiro next year;with a history of allergy to silver or any substance present in the different materials to be used for treatment. Besides that, teeth with spontaneous or provoked pain, dental mobility or radiographic signs of involvement or possible pulp involvement;shows possible pulp involvement by radiographic examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4752vs	Evaluation of desensitizing protocols in reduction of teeth hypersensitivity level	Recruiting	Intervention	2017-08-07	<NULL>	<NULL>	1317	Evaluation of desensitizing protocols in reduction of dentin hypersensitivity level - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4752vs	<NULL>	Healthy individuals of both sexes who are interested in the treatment of Dentin Hypersensitivity; Agree to participate and sign the informed consent form (TCLE); Patients with all teeth in their mouth; Patients with at least three teeth with Dentin Hypersensitivity in different quadrants.	Presence of dentin hypersensitivity caused due to the presence of caries or unsatisfactory restorations; Patients in orthodontic or periodontal treatment; Patients performing dental whitening; Presence of spontaneous  pain in the tooth with dentin hypersensitivity, characterizing pulpitis; Presence of periodontal disease; Unsatisfactory oral hygiene; Use of extensive prostheses; Patients with severe bruxism and loss of vertical dimension; Patients with uncontrolled gastroesophageal reflux disease; Patients with uncontrolled systemic and / or psychological diseases; Pregnancy and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-3pr9pp	Evaluation of different potassium oxalate concentrations in teeth hypersensitivity	Recruiting	Intervention	2017-08-07	<NULL>	<NULL>	1318	Clinical evaluation of different potassium oxalate concentrations in dentin hypersensitivity treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-16	Hospital Odontológico da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3pr9pp	<NULL>	The criteria for inclusion of the patients will be: healthy individuals who are interested in the treatment of Dentin Hypersensitivity; Agree to participate and sign the informed consent form (TCLE); Patients with all teeth in their mouth; Patients with at least two teeth with Dentin Hypersensitivity in different quadrants.	The criteria for exclusion of patients will be: presence of dentin hypersensitivity caused due to the presence of caries or unsatisfactory restorations; Patients in orthodontic or periodontal treatment; Patients performing dental whitening; Presence of spontaneous  pain in the tooth with dentin hypersensitivity, characterizing pulpitis; Presence of periodontal disease; Unsatisfactory oral hygiene; Use of extensive prostheses; Patients with severe bruxism and loss of vertical dimension; Patients with uncontrolled gastroesophageal reflux disease; Patients with uncontrolled systemic and / or psychological diseases; Pregnancy and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7fb2mm	Nutritional and Laboratory Parameters in Obese Patients Undergoing Two Hypocaloric Diets: Traditional Diet and Dukan Diet	Recruitment completed	Intervention	2017-08-07	<NULL>	<NULL>	1319	Evaluation of Biochemical, Metabolic, Nutritional and Cardiovascular Risk in Obese Patients Undergoing Two Hypocaloric Diets: Traditional Diet and Restricted Carbohydrate Diet	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-15	Universidade Federal de são Paulo -UNIFESP	Universidade Federal de são Paulo -UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7fb2mm	<NULL>	age 19 to 65 years old and obesity grade 1 and 2 (BMI 30 kg/m² to 39,9 kg/m²)	"Patients in primary or secondary prevention of coronary artery disease with LDL-C levels greater than 190 mg / dL and triglycerides greater than 400 mg / dL;
Diabetes mellitus;
Untreated hypothyroidism;
Liver disease;
Chronic renal insufficiency;
Cardiac insufficiency;
Systemic infections;
Failure to accept the conditions necessary to conduct the research"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5mhgpz	Interval Exercise of High Intensity and Continuous Exercise of Moderate Intensity	Recruitment completed	Intervention	2017-08-07	<NULL>	<NULL>	1320	Interval Exercise of High Intensity and Moderate Continuous	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-05	Departamento de Educação Física	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5mhgpz	<NULL>	Men aged 20-35 years; Insufficiently active (less than 150 minutes of moderate exercise per week).	Smokers; Chronic non-transmissible degenerative disease such as hypertension or diabetes; Use of any medication that influences the function of the cardiovascular system; Use of anti-inflammatory drugs; Any type of ergogenic agent; Bone or muscle limitation for maximum physical exertion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5mvff4	Electromyography of cough in subjects with Spinal Cord Injury	Recruiting	Observational	2017-08-01	<NULL>	<NULL>	1321	Mapping of the Surface Electromyographic Signal in the pectoralis major muscle during the cough in subjects without and with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-10	Faculdade de Medicina da Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5mvff4	<NULL>	Group of spinal cord injury (LM): Individuals with traumatic spinal cord injury with motor level of injury between C8 and T11; Minimum age of 18 years; Hemodynamically stable; And that they agree to participate in the research and sign the Free and Informed Consent Form. Control group (CG): Healthy individuals; No history of chronic and / or active disease; Individuals who formally agree to participate in the research and sign the Informed Consent Form.	"Individuals with a previous history of neurological diseases, such as Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Cranio-encephalic Trauma and
Stroke; Individuals with cognitive impairment, active lung disease and dependents of mechanical ventilation. Individuals with an infectious process with clinical and / or laboratory abnormalities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-28br3m	Postoperative renal function analysis in Cardiac Surgery in patients undergoing inhalation anesthesia	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1322	Postoperative renal function analysis in Cardiac Surgery with Cardiopulmonary bypass in patients undergoing inhalation anesthesia with Sevoflurane using low fresh gas flow	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-24	Hospital São José	Unesp - Universidade Estadua Paulista Júlio de Mesquita Filho - Campus Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-28br3m	<NULL>	Age between 20 and 80 years; both sexes; physical status ASA II and III; preoperative creatinine values are less than 1.3 mg.dL-1.	Patients in emergency or urgent surgery; use of intra-aortic balloon counterpulsation in the preoperative period; left ventricular ejection fraction of less than 0.4; type III diastolic dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-2d9ny6	Prevalence of chronic kidney patients with gluten intolerance and implementation of dietary strategies	Recruitment completed	Intervention	2017-08-08	<NULL>	<NULL>	1323	Prevalence of Celiac Disease among patients with chronic kidney diseases and implementation of dietary strategies	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Departamento de Nutrição e Saúde	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-2d9ny6	<NULL>	Chronic kidney patients; both sexes; aged over 18 years; in hemodialysis 3 times a week for at least 3 months.	Chronic kidney patients with hearing impairment; with hepatitis B and C virus; with newly implanted catheter;, hemodynamic instability; lactose intolerance or milk discomfort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-72mvj5	Effects of Alternative Foods on Muscular and Fat Mass of children	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1324	Nutritional effects of Protein-Energy Fortification of school meals for children in situation of Food Insecurity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-72mvj5	<NULL>	Children aged 6 to 11 enrolled in the 1st, 2nd or 3rd years of elementary school of a public school in the city of Santa Maria - RS - Brazil, and who responded positively to the invitation (written and spoken) to participate in the study; children whose parents or guardians voluntarily signed the Informed Consent Term.	Children with a history of chronic-degenerative diseases (diabetes, liver or kidney disease); children with  edema; children with soy allergy; children who attended classes less than 80% of the days used for intervention in phase II of the study; children who missed any of the nutritional assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7wcmd6	The effect of Strength Training on Unstable Surfaces on the functional performance of the elderly	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1325	Effect of Unstable Surfaces on Neuromuscular Training on the functional performance of elderly with a history of falls: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade de Pernambuco	Centro Universitário Tabosa de Almeida ASCES - UNITA	https://ensaiosclinicos.gov.br/rg/RBR-7wcmd6	<NULL>	Age equal or superior to 60 years; does not present conditions and / or diseases that limit or disqualify participation in the physical training program; stable from the point of view of medication;	Present low adherence to the training (frequency less than 75% of the sessions in a period of one month; present some limiting or incapacitating health impairment during the intervention; are involved in another physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-6724wt	Influences of the Types of Play in the Performance of the Throwing of Children With Normal Development	Not yet recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1326	Influence of Playing Practice on Typical Children&apos;s Throwing Performance	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-6724wt	<NULL>	Children capable of carrying out the proposed test; With absence of intellectual compromises; Neuropsychomotor; musculoskeletal	Children with physical and / or intellectual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-2q53ct	Self-care Education: A Comparative Study of the Quality of Life of Patients With Head and Neck Cancer	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1327	Education for Self-management: A Comparative Study of the Quality of Life of Patients With Head and Neck Neoplasia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2q53ct	<NULL>	Patients with head and neck neoplasia; Submitted to the first oncological treatment; Both sexes; older than 18 years; Less than 80 years.	Patients with previous oncological treatment, patients diagnosed with psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-36cw3y	Strength Training for patients with Parkinson&apos;s Disease identified by a biochemical examination	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1328	Resistance Training Program for patients with Parkinson&apos;s Disease diagnosed by molecular analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-36cw3y	<NULL>	Volunteers diagnosed with Parkinson&apos;s disease by a neurologist specializing in movement disorder; both genders; age greater than or equal to 60 years; stage 1-3 on the Hoehn and Yahr scale; and stable use of medication.	Severe cognitive impairment (Mini-Mental State Exam score &lt;24); inability to walk independently; neurological, cardiopulmonary or orthopedic diseases; have participated in some exercise protocol prior to this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7gr6js	Effects of video game therapy in the management of gait in chronic post-stroke individuals	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1329	Effects of virtual reality therapy in the treatment of gait in chronic hemiparetic individuals after ischemic stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-09	Universidade de Araraquara (UNIARA)	Universidade de Araraquara (UNIARA)	https://ensaiosclinicos.gov.br/rg/RBR-7gr6js	<NULL>	Inclusion criteria were the occurrence of stroke episode (single, unilateral, ischemic) at least 6 months before the beginning of the study, minimum score in the Mental State Mini Exam according to the volunteer&apos;s level of education and in the item &quot; &quot;(2 points) of the Admissional Scale. In addition, maintenance of standing posture was necessary without support or use of a walking aid for one minute according to item 2 of the Berg scale.	Exclusion criteria for a presence of cardiovascular diseases; cognitive or communication deficiencies that preclude a procedure exercise; antecedents of joint or muscular injuries in the lower limbs (fractures, dislocations or surgery and generalized ligament laxity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-5rxr2b	Supplementation of juçara fruit pulp in the alterations in intestinal flora and inflammation in obese individuals	Recruitment completed	Intervention	2017-08-14	<NULL>	<NULL>	1330	Supplementation of the juçara palm fruit  (Euterpe edulis Mart.) In the modulation of the microbiota and inflammatory state in adults	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade Federal de São Paulo	Angiocorpore Medicina Cardiovascular	https://ensaiosclinicos.gov.br/rg/RBR-5rxr2b	<NULL>	Volunteers with obesity grade I and II (BMI between 30.0 and 39.9 kg / m2); Both genders; Age between 30 and 59 years	Eutrophic, low weight or with degree II obesity volunteers; Diagnoses of infectious diseases and / or severe chronic diseases; In use of anti-inflammatory and antibiotic drug; History of alcohol and drug abuse; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4j9fxq	Healthy feeding practices and nutrition in the school environment: construction, development and evaluation	Recruitment completed	Intervention	2017-08-14	<NULL>	<NULL>	1331	Healthy feeding practices and nutrition in the school environment: construction, development and evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Universidade Federal do Espírito Santo	Fundação de Amparo à Pesquisa do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-4j9fxq	<NULL>	children of both sexes of two public schools; 7-10 years old; Assent Term delivery signed by the student and Free Informed Consent form by the responsible.	Introduced less than 7 years and above 11 years of age; possess physical impairment that precludes data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6w5gwh	Clinical evaluation of non-carious cervical lesions of different sizes, restored with two resin composite	Recruitment completed	Intervention	2017-08-15	<NULL>	<NULL>	1332	Longitudinal clinical evaluation of non-carious cervical lesions of different sizes, restored with bulk-fill or conventional resin composite: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6w5gwh	<NULL>	At least 18yrs old; good health; do not have active caries or periodontal disease; to have non carious cervical lesions, in canines and premolars, at least 1 mm depth; to have at least 1 lesion; to have antagonist and adjacent teeth; teeth must to present vital pulp; no parafunctional habits.	Medical condition that may interfere with the safety of the volunteer during the study period, or allergic reactions to the substances and / or products will be used; use of removable prostheses which have the clamps resting on the teeth used for the research; parafunctional habits; smoking patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-7rbnh6	Effects of Pilates in Sedentary Adults	Recruiting	Intervention	2017-08-15	<NULL>	<NULL>	1333	Influence of Pilates Practice on Physical Composition, Functionality, Body Posture, Life Quality, and Autonomic Modulation in Adults	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7rbnh6	<NULL>	Volunteers of both genders, with technical unfamiliarity with respect to the Pilates Method; to be sedentary; absence of current inflammatory processes derived from musculoskeletal or cardiopulmonary diseases, and absence of previous surgeries on back and abdominal regions.	Presence of some clinical condition at the recruitment moment in order to preclude or to result risk factor to damage or to hurt the volunteer; to use regular medicine which reverberate effects on cardiopulmonary system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-943djg	Effects of branched-chain amino acid consumption in association with omega-3 in clinical-nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	Recruiting	Intervention	2017-08-16	<NULL>	<NULL>	1334	Impact of branched-chain amino acid supplementation on omega-3 association in clinical, nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal do Maranhão - UFMA	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-943djg	<NULL>	Individuals over 18 years of age; pre-cachexia; cachexia; stability (absence of modifications in drug therapy in the last 6 weeks or hospitalizations in the last 3 months).	Individuals over 85 years of age; refractory cachexia (pre-terminal state, life expectancy &lt;3 months, intense catabolism, lack of response to drug therapy); palliative care; use of branded step; water imbalance; allergy to nutritional composition of supplements; withdrawal of consent; adherence to intervention of less than 75%; refusal of proposed supplementation; worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-2b4bzq	Vibrations to treat rheumatism	Recruiting	Intervention	2017-08-17	<NULL>	<NULL>	1335	Evaluation of the effect of mechanical vibrations generated on oscillating / vibratory platform in patients with systemic lupus erythematosus and bone mass impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade do Estado do Rio de Janeiro	Laboratório de Vibrações Mecânicas e Práticas integrativas e complementares - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-2b4bzq	<NULL>	Signature of the Informed Consent Term; patients older than 40 years and female; followed up at HUPE; lupus diagnosed for at least 6 months (ACR criteria 1997, Hochberg, 1997); use of glucocorticoids for 3 years or more; patients with blood pressure (BP) equal to or greater than 100 x 70 mmHg	Presence of neurological / e or psychiatric disease that causes fear to the movements on the oscillating / vibratory platform; severe or incapacitating clinical illness; at the discretion of the investigator; Previous history of low-impact fracture and or classified as severe osteoporosis; personal history of avascular hip necrosis; active smoking; Alcoholism; use of joint protheses; patients refusing to sign the term Of Consent to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4mgxzw	“Validation of fact-p questionnaire to evaluate quality of life in brazilian men with prostate cancer&quot;	Recruiting	Observational	2017-08-17	<NULL>	<NULL>	1336	“Fact-p instrument validation in brazilian men with prostate cancer&quot;	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4mgxzw	<NULL>	Patients older than 45 years with diagnosis of prostate cancer and staging I, II or III.	Patients with advanced prostate cancer, neurological diseases, insulin-dependent diabetes, penile prosthesis and other tumors; those with difficulty speaking, hearing or understanding the portuguese language; those who have been previously submitted to any kind of treatment of prostate cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3p8g7n	Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	Recruiting	Intervention	2016-08-03	<NULL>	<NULL>	1337	A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-06-01	Instituto Dante Pazzanese de Cardiologia	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3p8g7n	<NULL>	Male or female at least 18 years old at the time of consent; subject has signed an ICF; at least one blood culture positive for S. aureus within 48 hours before randomization; in addition to the QBC, subject must have at least one of the following signs or symptoms of bacteremia: temperature higher or equal to 38.0°C, white blood cell (WBC) count higher 10,000 or less than 4,000 cells/µL, or higher 10% immature neutrophils (bands) regardless of total peripheral WBC count; tachycardia (heart rate higher 90 bpm); tachypnea (respiratory rate higher 20 breaths/min); hypotension (systolic blood pressure less than 90 mmHg); signs and symptoms of localized catheter-related infection; subject must, at enrollment, have either 1) known right-sided infective endocarditis by Modified Duke’s Criteria, 2) known complicated bacteremia, demonstrated as signs or symptoms of metastatic foci of S. aureus infection, or 3) known bacteremia with at least one of the following risk factors for complicated bacteremia: any venous catheter considered to be the source of the infection, demonstrated by inflammation or purulent drainage from the catheter insertion site AND evidence of catheter-associated thrombosis upon removal; a central venous catheter considered to be the source of infection; a long-term intravascular catheter considered to be the source of infection; new onset cardiac murmur consistent with tricuspid regurgitation; community onset bacteremia; pathogen known to be MRSA at enrollment; duration of symptoms higher or equal to 2 days at time of presentation (prior to start of antibiotic therapy); skin exam findings suggesting acute systemic infection; willing to receive intravenous antibiotics for the duration of treatment; expected survival of at least 3 months; female subjects must be non-pregnant and non-lactating; if sexually active, must agree to use a highly effective method of birth control with partners of childbearing potential during the study and for 1 month after study drug dosing; considered likely to comply with the study procedures and to return for scheduled evaluations.	"Treatment with any potentially effective (anti-staphylococcal) systemic antibiotic for more than 60 hours within 7 days before randomization; requirement or anticipated requirement of non-study systemic antibiotics during the study; presence of an infection source that will not be managed or controlled within the first 3 days of study drug treatment; presence of prosthetic cardiac valve or cardiac device; known or suspected left-sided infective endocarditis (LIE), at enrollment, according to Modified Duke Criteria; at the time of enrollment, known or highly suspected osteomyelitis, meningitis, or metastatic septic foci involving the central nervous system (CNS); Known at the time of enrollment to have MRSA bacteremia that is non susceptible to daptomycin AND has a vancomycin MIC higher or equal to 2 microg/mL; confirmed evidence of a mixed polymicrobial infection with a Gram-negative pathogen that requires non-study antibiotic treatment with agent(s) that have activity against Gram-negative pathogens; previous participation in an anti-infective study during the past 12 months; history of significant hypersensitivity, allergy or intolerance to telavancin; solid organ transplantation or bone marrow transplantation within 6 months before randomization; severe neutropenia, defined as an absolute neutrophil count (ANC) less than 500 cells per microliter, or expected development of severe neutropenia during study; known or suspected human immunodeficiency (HIV) infection with a CD4+ T-cell count less than 200/µl within the previous 6 months; subjects requiring concomitant administration of anti-coagulation therapy AND requiring specific coagulation testing known to have interference by telavancin; severe liver disease, ie, Child-Pugh Class C, or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 10 times the upper limit of normal (ULN); requirement for acute renal replacement therapy; or acute kidney injury (AKI) defined as an acute decrease in creatinine clearance (CrCl) to less than 30 mL/min and at least one of the following: higher or equal to 2x increase in serum Cr or 50% decrease in glomerular filtration rate (GFR) within the 2 weeks prior to enrollment (RIFLE stage 2 injury); oliguria defined as urine output less than 0.5 mL/kg per hour for higher ot equal to 12 hours at any time during screening; Shock or hypotension (supine systolic blood pressure 
less than 80 mm Hg) unresponsive to fluids or pressors within 24 hours prior to randomization; QTc higher than 460 ms (using either the Bazett or Fridericia formula), congenital long QT syndrome, uncompensated or new onset heart failure, aortic stenosis, aortic insufficiency, or mitral insufficiency; serum creatine kinase (CK) higher or equal to 2000 U/L; breast-feeding or pregnant or intending to become pregnant (self or partner) at any time during the study; any other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject or would render the subject unable to comply with the protocol; or any other condition that in the opinion of the investigator may confound the data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3h4x97	The effect of Dietary Protein Addition on nutritional status and clinical evolution in children and adolescents admitted to the Pediatric Intensive Care Unit	Recruiting	Intervention	2017-08-17	<NULL>	<NULL>	1338	Effect of Protein Supplementation on nutritional status and clinical outcomes in Critically Ill Children on enteral nutritional therapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-19	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-3h4x97	<NULL>	children of both sexes; aged 1 month to 14 years 11 months and 29 days of age; hospitalized for a maximum of 72 hours; with indication of enteral nutrition with polymeric diet.	discharge or death in the first 48 hours; inability to initiate enteral nutrition in the first 72 hours; use of parenteral nutrition; admission for moderate to severe burn; allergy to cow&apos;s milk protein or innate error metabolism; hepatic encephalopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-8d4vkr	Effect of brushing associated with oral irrigation on tissue around implants and mandibular prosthesis hygiene	Recruitment completed	Intervention	2017-08-18	<NULL>	<NULL>	1339	Effectiveness of brushing associated with oral irrigation in maintenance of peri-implant tissues and overdentures – randomized clinical trial.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-12-09	Faculdade de Odontologia de Ribeirão Preto - USP	Faculdade de Odontologia de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-8d4vkr	<NULL>	Adult, healthy and complete edentulous subjects, both genders, use of maxillary conventional complete dentures and mandibular overdentures retained by 2 to 4 implants, and with an O-ring-retained system; clinically satisfactory prostheses; implants and overdentures in function for at least 6 months, and the retention rings, from 1-6 months.	Uncontrolled diabetic patients; immunossupressed patients; use of antibiotics, antifungals or corticosteroids in the last 3 months; current use of anticoagulants, anticonvulsants, and immunossupressants; relined, repaired or fractured prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6z6k27	Physical therapy and funcional performance after breast cancer surgery	Recruiting	Intervention	2017-08-18	<NULL>	<NULL>	1340	Physical therapy after breast cancer surgery: focus on funcional performance and quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-25	Universidade Federal de Sergipe (UFS)	Fundação Beneficência Hospital Cirurgia	https://ensaiosclinicos.gov.br/rg/RBR-6z6k27	<NULL>	Women submitted to breast cancer surgery including axillary linfadenectomy, attending physical therapy three times a week, more than 18 years	Women with breast implant, bilateral mastectomy, skin lesions or infeccions on arm, active infectious processes (erysipelas) and breast reconstruction with use of large dorsal and abdominal rectus muscles, breast reconstruction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4jyr4r	Pilates in the Treatment of Chronic Low Back Pain	Recruiting	Intervention	2017-08-23	<NULL>	<NULL>	1341	Effects of Pilates Method Exercises in Chronic Nonspecific Low Back Pain, Functional Capacity and Quality of Life: A Randomised Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-08	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4jyr4r	<NULL>	Age between 18 and 59 years; Symptoms of pain or stiffness in the pelvic loin region with or without irradiation symptoms to the lower limbs; Pain on most days of the week for more than 3 months; Good understanding of written and spoken Portuguese.	Lumbar disc herniation with or without loss of sphincter control or saddle paresthesia; Equine tail lesion; Spinal surgery; fever; infection; Night sweats or chills; Unexplained loss of weight or appetite; History of cancer or malignancy; Pregnancy or the possibility of pregnancy in the next 6 months; Spinal fractures or diagnosed osteoporosis; Inflammatory disease of the spine such as ankylosing spondylitis and rheumatoid arthritis; Chronic obstructive pulmonary disease and restrictive diseases; Comorbidity that may prevent exercise; Participation in any exercise program in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-5h4y4n	Laser effect in the treatment of mouth wounds caused by the treatment of head and neck cancer	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1342	The low level Laser therapy in the treatment of Oral Mucositis in patients with head and neck cancer submitted to radiotherapy and chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-12	Universidade Federal de Goiás	Hospital Araújo Jorge - Associação de Combate ao Cancer em Goias	https://ensaiosclinicos.gov.br/rg/RBR-5h4y4n	<NULL>	Volunteers with more than 18 years. Both sexes. Toothed or edentulous. With cancer of the head and neck that will undergo radiotherapy (minimum dose of 50Gy) and chemotherapy	Volunteers with tumors of salivary glands or Sjogren&apos;s syndrome. Patients previously submitted to radiotherapy in the head and neck region or chemotherapy. Patients with lymphoma. Patients with melanoma. Patients with skin cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6ys9yp	Evaluation of the effect of vitamin E supplementation on vitamin A values of mother and child	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1343	Evaluation of maternal vitamin E supplementation on retinol levels in serum and breast milk	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-12	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6ys9yp	<NULL>	Lactating women; normal birth; term delivery; age between 18 and 40 years.	Women with signs of clinical pathology; Infections; syphilis; HIV; Diseases of the gastrointestinal tract; Liver diseases; heart diseases; diabetes; hypertension; cancer; Mental disorder; Twin childbirth; Newborn with fetal malformations; Abortion history; Use of antithrombotics; Use of supplements containing vitamin E and / or A during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-683dtp	Evaluation of the effect of Electrical Stimulation on erectile dysfunction after Prostate Cancer surgery	Recruitment completed	Intervention	2017-08-24	<NULL>	<NULL>	1344	Assessment of the effect of Transcutaneous Nerve Stimulation of corpus cavernosum rehabilitation after Radical Prostatectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-17	Escola Paulista de Medicina	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-683dtp	<NULL>	Men; satisfactory erectile function before radical prostatectomy; 40 to 70 years old.	Patients with erectile dysfunction; residual prostate cancer post surgery or need of radiotherapy; metalic implants in the pelvic region; spinal cord injury; alteration of genital sensitivity or cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-5hnk3r	Effects of Probiotic Supplementation versus Placebo on Intestinal Function in adult women	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1345	Effects of Probiotic Supplementation on Intestinal Function in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Mato Grosso	Vitafor©	https://ensaiosclinicos.gov.br/rg/RBR-5hnk3r	<NULL>	"Women between the ages of 20 and 40; who are classified as constipated according to the ROME III criteria are;
Maintain the same diet and routine of daily activities; and sign the Informed Consent Term."	Not to be classified as constipated according to the criteria of ROME III; Not sign the Free and Informed Consent Form; Abstain from treatment for one day; To change their eating routine or exercise during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3fqb7f	The impact of information on the corrected age in the development of premature baby and parents everyday	Data analysis completed	Intervention	2017-08-25	<NULL>	<NULL>	1346	The impact of Corrected Age information on the development of Preterm Infants and their parents&apos; Daily Lives	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-12	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3fqb7f	<NULL>	Infants enrolled in the Neonatal Intensive Care Unit Preventive Care Program; Corrected age less than two 24 months; First consultation; Signature of the Consent Form and clarified by one of the parents or guardian	Infants with osteomyelitis; Neonatal neurological disorders; Diagnosed in social vulnerability; Parent mental issues	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-37vvwk	Brazilian version of Pre-PAQ Questionnaire	Not yet recruiting	Observational	2017-08-25	<NULL>	<NULL>	1347	Brazilian version of Preschool-age Children&apos;s Physical Activity Questionnaire (Pre-PAQ)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-37vvwk	<NULL>	Professional in the field of physical education; Professional physiotherapy; Occupational therapy	Less than 2 years of training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4gs6s3	Seed treatment under stress analysis in women who work more than 30 hours a week	Data analysis completed	Intervention	2017-08-28	<NULL>	<NULL>	1348	Auriculotherapy for stress management in women who work more than 30 hours a week	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Paulista-Campus São José do Rio Pardo	Universidade Paulista-Campus São José do Rio Pardo	https://ensaiosclinicos.gov.br/rg/RBR-4gs6s3	<NULL>	Women; Individuals who present with stress symptoms; Working hours greater than 30 hours per week; Do not use drugs that will inhibit the autonomic nervous system.	Pregnant women; Use of medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-3d957w	Long-term effects of Blood Flow Restriction Walk on bone, muscle, and pleasure / displeasure in the elderly	Recruiting	Intervention	2017-08-28	<NULL>	<NULL>	1349	Chronic effects of Aerobic Training with Blood Flow Restriction (rfs) on bone health, neuromuscular performance and perception of pleasure / discharge in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3d957w	<NULL>	"Volunteers aged 60 years and over with osteopenia or osteoporosis, in a natural postmenopausal period, with at least 12 months of the last menstrual interval who did not undergo hormonal therapy until 3 months before the study; Do not practice aerobic training; Insufficiently active and functionally independent.
The volunteers who do not have obstructive artery diseases of the lower limbs (DAOMI) with ABI between 0.91 and 1.30; Osteomyelitis associated with intense pain, cardiorespiratory pain that make it impossible to perform physical activity, neoplasias, renal disease. Non-users of drugs that interfere with bone metabolism, non-smokers and those who do not use alcohol regularly will also be included."	Volunteers who have a frequency of less than 85%; Those who give up and those who present osteomyelitis pain or dysfunction during the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-37n859	New hospitalizations and correct Heart Failure treatment of patients with Heart Failure after hospital discharge orientation and telephone contact	Data analysis completed	Intervention	2017-08-28	<NULL>	<NULL>	1350	Rehospitalization and treatment adherence of patients with Heart Failure after hospital discharge orientation and telephone contact	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Instituto Dante Pazzanese de Cardiologia- SP	Instituto Dante Pazzanese de Cardiologia- SP	https://ensaiosclinicos.gov.br/rg/RBR-37n859	<NULL>	"&gt; 18 years old;
telephone number avaiable for after discharge;
admitted with heart failure in emergency;"	"&lt; 18 years old;
cardiac surgeryc in the last 3 months;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-99tdpn	The Effects of Pilates Exercise on Joint Pain and Mobility of Chikungunya Fever Patients	Recruiting	Intervention	2017-08-28	<NULL>	<NULL>	1351	The Effects of the Pilates Method on Pain and Joint Mobility of Chikungunya Fever Patients: A Randomized Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Bruna Fernanda Alves de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-99tdpn	<NULL>	Volunteers with diagnosis of Chikungunya Fever with more than 3 months of symptoms; Chronic phase of Chikungunya fever; Both genders; Age greater than or equal to 18 years.	Contraindication for performing physical exercises at the discretion of the attending physician; Severely limiting cognitive, auditory, visual or motor deficit; Do not sign the Free and Informed Consent Form; patients with pre-existing rheumatological diseases known.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-9gt5jw	Evaluation Pomegranate&apos;s Brute Ethanol Extract Mouthwash in the Periodontal Health of women in puerperium	Recruitment completed	Intervention	2017-08-28	<NULL>	<NULL>	1352	Evaluation of a Pomegranate&apos;s (Punica granatum L.) Brute Ethanol Extract (BEE) Mouthwash in the Periodontal Health of women in the postpartum period attended at Maternity Hospital “Dona Evangelina Rosa” in Teresina-PI, Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-21	UFPI - Universidade Federal do Piauí	UFPI - Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-9gt5jw	<NULL>	Postpartum women; resident in the urban area of the capital; aged 18 years or over; with periodontal disease (gingivitis or periodontitis); at least 20 teeth	Present healthy periodontium; smoking; present lesion in the oral mucosa; patient with diseases or systemic conditions with periodontal repercussions; immunocompromised puerperal women; in the use of antibiotics, anti-inflammatories or any other medicine that could influence the oral microbiota; in use of orthodontic appliances or removable dental prostheses, fixed with more than two elements; women who used mouthwash solutions in less than 30 days; women who had periodontal treatment in the last 6 months; history of hypersensitivity to any of the active principles of mouthwash	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2kch38	Effects of Stomach Reduction Surgery on oral health	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1353	Repercussions of Bariatric Surgery on oral health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-20	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-2kch38	<NULL>	Obese volunteers of both genders; aged between 16 and 60 years; with indication for stomach reduction surgery; who underwent bariatric surgery in the year 2015 and 2016.	Edentulous individuals; with physical limitations; with mental limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-3cqzfy	Effects of a Home Physical Exercise Program, with Monitoring every 15 Days, on Sleep Quality of the Elderly: a Randomized Clinical Trial	Recruiting	Intervention	2016-12-12	<NULL>	<NULL>	1354	Effects of a Non-Supervised and Guided Home Physical Exercise Program on Elderly Sleep Quality: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cqzfy	<NULL>	Resides in the urban area of the municipality of Senhor do Bonfim-Ba, is 60 years of age or older, has not exercised regularly for at least three months prior to the study, score less than or equal to 5 on the Pittsburgh Sleep Quality Index (PSQI-BR).	Participants with cognitive decline according to the Mental State Mini-Exam will be excluded from the study, they will be performing some treatment for sleep disorder (including the use of sleeping pills more than once a week) and present any Clinical condition that contraindicates the performance of physical activity, identified through a medical and physiotherapeutic evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2hncgg	Hippotherapy effects of hand function in children with Cerebral Palsy	Recruitment completed	Observational	2017-08-29	<NULL>	<NULL>	1355	Hippotherapy effects in the upper limb function of children with Cerebral Palsy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2hncgg	<NULL>	Children with the diagnosis of cerebral palsy; age group of 5 years and 14 years; GMFCS level between I and IV;	Presence of comorbidities; Recurrent seizures; Had surgery or chemical / neuromuscular block in the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-3xhsjx	Analysis of Body Temperature and Energy Spending during Aerobic Training with and without Blood Flow Restriction  in physically active subjects	Recruitment completed	Intervention	2017-08-29	<NULL>	<NULL>	1356	Analysis of the Thermographic Standard and Energy Expendutire during Aerobic Training with and without Blood Flow Restriction  in physically active subjects: a controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-3xhsjx	<NULL>	Young adults physically active; No presence or history of osteoarticular or muscular diseases in the lower limbs; That respond negatively to the Physical Activity Readiness Questionnaire; They present Brachial Ankle Index between 0.91 and 1.30; Physically active.	Missing one of the evaluations; If injured during the study; Can not adapt to the training proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-45v5sw	Evaluation of the impact of the Living with Style and Health Program on prevention and control of Diabetes and Hypertension	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1357	"Living with Style and Health Program:
pilot study of an educational approach for the prevention and control of Diabetes and Hypertension"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-15	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-45v5sw	<NULL>	Volunteers over 18 years of age; Both genders; With or without diagnoses of diabetes or hypertension.	Volunteers under the age of 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4mmvpc	Mindfulness Training for university students with symptoms of Depression, Anxiety and Stress	Recruiting	Intervention	2017-08-29	<NULL>	<NULL>	1358	Mindfulness Based Cognitive Therapy Program for university students with symptoms of Depression, Anxiety and Stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4mmvpc	<NULL>	Be regularly enrolled in UFMG; Men and women with age between 17 and 60; Presenting symptoms of depression (mild and moderate) with BDI-II scores between 14 and 28; To present anxiety symptoms with BAI scores&gt; 0To present stress symptoms with scores in PSS&gt; 0	Do not present recent history (past 12 months) of severe psychopathology (psychosis, risk and suicide attempt, Panic Disorder and posttraumatic stress disorder); Having epilepsy or some neurocognitive disorder; Be in psychological treatment (last 6 months); Practice mindfulness meditation with frequency (last 6 months).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-33t6zm	Physical Exercise To Improve Cerebral Circulation In Kidney Disease	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1359	Influence Of Intradialytic Aerobic Training On Cerebral Blood Flow And The Reflex On Cognitive Function And Quality Of Life In Chronic Renal Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Estadual Paulista - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-33t6zm	<NULL>	Patients with Chronic Kidney Disease in hemodialysis treatment for a period of more than or equal to 3 months; stable medication; no contraindications for performing physical activity	Inability to understand the procedures performed; previous diagnosis of coronary artery disease; previous positive exercise test for cardiac ischemia; patient classified as active or very active based on the instrument applied; patient suffering from stroke; carrier of neoplasia; infection Acute or chronic in activity; HA Stage II; previous diagnosis of dementia; delirium; presence of depression;use of drugs that influence cognitive function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-6m2fch	"A food compound with a preventive effect and / or treatment in lipid and glycemic disorders
In HIV-positive individuals on antiretroviral therapy"	Recruitment completed	Intervention	2017-08-29	<NULL>	<NULL>	1360	Bioactive Compound: nutritional therapy in the lipid and glycemic alterations caused by HIV infection in individuals using combined antiretroviral therapy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de Mato Grosso do Sul	Secretaria de Saúde Municipal de Campo Grande	https://ensaiosclinicos.gov.br/rg/RBR-6m2fch	<NULL>	Having aged 18 years or more; being on ART using or not lipid-lowering or hypoglycemic medications; perform laboratory tests according to request and control medical; participate from beginning to end of study and having signed the Term of Free and Informed.	Do not meet the inclusion protocol; Be a carrier of mental and renal diseases; Being pregnant; Be indigenous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-9mvgrq	Effect of three bandages on the flat foot of healthy young adults	Recruiting	Intervention	2017-08-29	<NULL>	<NULL>	1361	Effect of rigid, elastic and hyperelastic banding on excessive pronation of healthy young adults: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade de Brasília	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9mvgrq	<NULL>	"Authorize the evaluation and the procedure by means of the Free and Clarified Consent in accordance with the resolution CONEP / CNS Nº. 466/2012;
Being male;
Age range between 18 and 30 years;
To present a body mass index between 18.6 and 24.9 kg / m²;
Have no history of injury in the last 6 months in the lower limbs;
Present at least one pronated foot"	"History of musculoskeletal and / or neurological lesions that may affect gait;
History of surgeries and / or traumas of any nature in lower limbs, pelvis or spine in the last six months that may affect gait;
Present allergy to some type of bandage or tissue, evaluated through allergy test;
Have recently done or still do treatment for PE;
Having cutaneous or malignant diseases and bacterial infections in the place to be applied the bandages;
Report any pain or any sign of injury during the evaluations;
Make use of medicine that impairs balance, such as sedative or hypnotic;
Intake of alcoholic beverages within 48 hours prior to evaluation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4bxrfy	Hiking effects on quality of life during Chemotherapy treatment of Breast Cancer	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1362	Quality of life in women submitted to Chemotherapy on post-operative Breast Cancer: hiking effects on Myelosuppression and Muscle Fatigue	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Instituto Radium de Campinas Ltda (filial São João da Boa Vista)	Rebeca Garcia Rosa Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4bxrfy	<NULL>	Women on adjuvant chemotherapy; who were in the second, third or fourth cycle of chemotherapy; and who performed the cycle of Doxorubicin and Cyclophosphamide use.	Women who have had radiation therapy or hormone therapy; who performed the cycle of use Placlitaxel or FEC (Fluorouracil, Epirubicin and Cyclophosphamide); who had high cardiac risk on the echocardiogram; above 75 years of age; unable to respond to questionnaires; with distant metastasis; and unable to walk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2tbjpk	The challenges of providing dental care to adults with Down syndrome	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1363	Conscious sedation technique with oral midazolam for dental treatment in adult patients with Down&apos;s Syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-09	School of Dentistry Universidad de Buenos Aires	School of Dentistry Universidad de Buenos Aires	https://ensaiosclinicos.gov.br/rg/RBR-2tbjpk	<NULL>	"All patients with Down syndrome; older than 18 years; negative behavior for dental care;, 
 controlled Hypertension; controlled hypothyroidism; controlled diabetes"	All patients with Down syndrome, who showed no change in behavior and were receptive to dental treatment; Down syndrome patients who were uncontrolled hypertension; type 1 diabetes; respiratory failure; asthma and renal failure; patients can be treated by the dentist after receiving counseling; all patients with medical contraindications for the use of midazolam.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-7ygspd	Study of the treatment of children and adolescents with diffuse brainstem tumors using Valproic Acid with Chemotherapy and Radiation Therapy	Withdrawn	Intervention	2016-05-30	<NULL>	<NULL>	1364	Clinical trial of valproic acid with radiochemotherapy for diffuse pontine intrinsic glioma patients	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-01-02	Hospital Infantil Albert Sabin	Hospital Infantil Albert Sabin	https://ensaiosclinicos.gov.br/rg/RBR-7ygspd	<NULL>	Patients between 0 and 18 years  diagnosed with DIPG by imaging. Absence of acute cerebral bleeding. It includes subdural hematoma, subarachnoid and intraparenchymal bleeding. No prior treatment with chemotherapy or radiotherapy.	History of recent head trauma. Coma with brain herniation. Coagulopathy (platelet counts &lt;50,000 / mm3, INR&gt; 1.8). Previous recent use of valproic acid. Use of other anti-convulsant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4zx26w	Measurement of thigh muscle strength in patients with knee arthrosis who will receive a lubricating injection to the knee and who will do bodybuilding	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1365	Evaluation of knee extension and bend strength in patients with knee arthrosis who will receive and will not receive an injection in the knees of HILANO GF-20 and who will do bodybuilding	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-07	Hospital Universitario Clementino Fraga Filho	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-4zx26w	<NULL>	Sedentary women or that had spent at least a minimal period of six months without any kind of exercising;clinic and radiological diagnosis of gonarthrosis level II and III; pain complaint equal to or higher than 6 according to the Visual Analog Scale.	Non-collaborative patients; who were illiterate or who answered less than 85% of the questions due to difficulty in understanding, presenting with comorbidities that interfered with the performance or the execution of the exercises or that presented cardiovascular risk to the practice of the exercise, fracture sequelae, large joint angular deformity, joint blockage; ankyloses that were eligible for any surgical procedure or that had already undergone any surgical treatment in the knees; had any hypersensitivity related to poultry proteins in their clinical history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-7q9xh5	Study Protocol of Effectiveness Evaluation of the Strengthening Families Program in Brazil	Recruiting	Intervention	2017-09-05	<NULL>	<NULL>	1366	Effectiveness, Implementation Quality and Social Validity Evaluation of the Strengthening Families Program	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto de Psicologia da Universidade de Brasília	Secretaria Nacional de Políticas sobre Drogas - Ministério da Justiça	https://ensaiosclinicos.gov.br/rg/RBR-7q9xh5	<NULL>	Families with children between 10 and 14 years of age; concurrent participation of the child/adolescent and at least one parent/guardian; users of public services intended for economically disadvantaged families.	Children/adolescents participating in other evidence-based preventive programs with similar goals; families with rights violations, such as children suffering severe mistreatment; families whose children/adolescents are problematic drug users in need of treatment; and families whose parents are not available to accompany the child/adolescent throughout the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7x3tkf	Physical Activity for men in Andropause	Recruitment completed	Intervention	2017-09-05	<NULL>	<NULL>	1367	The impact of Physical Activity on Androgenic Deficiency in the Aging Male and Associated Factors	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7x3tkf	<NULL>	Men; androgen deficiency in the aging male; between 40 and 59 years.	Cardiovascular diseases; Neurological; musculoskeletal; prostate cancer; Functional training in the three months prior to data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6xqt44	Mais Viver Project: Physical Exercise and Nutritional Attendance program for elderly woman	Recruitment completed	Intervention	2017-09-05	<NULL>	<NULL>	1368	Impact of Dietary Intervention and Exercises on body composition and metabolic and molecular biomarcators: randomized and controlled clinical test on Overweight elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-6xqt44	<NULL>	Woman; above 50 years older	Absence of severe musculoskeletal diseases; recent nutritional monitoring	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-5bt6kd	The effect of Platelet-rich Plasma and Corticosteroids in treatment of shoulder Tendinitis	Data analysis completed	Intervention	2017-09-05	<NULL>	<NULL>	1369	Comparative study of Platelet-rich Plasma and Corticosteroids in treatment of Rotator Cuff Tendinopathy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-05-31	Universidade Tiradentes	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-5bt6kd	<NULL>	age between 18 and 70 years old; positive Neer test; no previous treatment of IV corticosteroids, injectable or oral in the last 12 months; hemoglobin greater than 11g/dl; platelet count greater than 150000/mm³; and signature of the informed consent form.	association with adhesive capsulitis; complete rupture of the rotator cuff in ultrasonography; loss of follow-up and use of oral or parenteral corticosteroids during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-3qy2f2	"Evaluation of Vitamin D Supplementation on heart health, muscle strength and 
Body fat in twins"	Recruiting	Intervention	2017-09-05	<NULL>	<NULL>	1370	Supplementation with Vitamin D assessment on Physical Fitness: study heritability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Pós Graduação em Ciências da Saúde	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3qy2f2	<NULL>	Pairs of twins of the same sex. aged 20 and 45. healthy.	individuals with physical disabilities or musculoskeletal limitations that prevent walking or running activity; indivíuos drug therapy related to obesity or using vitamin supplement containing vitamin D; pairs of twins of different sexes; individuals with conditions such as hypertension, diabetes, liver disease, heart disease, infectious or some chronic degenerative disease; pregnant women and individuals who have negative responses to the Physical Activity Readiness Questionnaire (PARq).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6mgqn3	The use of Aromatherapy associated with Massagem on Stress from a nursing staff at the surgical center	Data analysis completed	Intervention	2017-09-11	<NULL>	<NULL>	1371	Aromatherapy with Massage on Stress from a nursing staff at the surgical center	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Departamento de Enfermagem da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6mgqn3	<NULL>	Healthy volunteers; both genders; age between 18 and 60 years; to be working regularly in the sector (surgical center); to consent participate in the research by signing the Free and Informed Consent Form; achieve a minimum score of 12 points on Vasconcelos Stress Symptom List; olfactory acceptance of the odor of lavender (Lavandula angustifolia) and geranium (Pelargonium graveolens) essential oils; and declare not being pregnant.	Loss of follow-up of aromatherapy massage sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7nkxkf	Strength and Balance training improve functional capacity in institutionalized Elderly	Data analysis completed	Intervention	2017-09-11	<NULL>	<NULL>	1372	The influence of Strength Training, Endurance and Balance in institutionalized Elderly: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Centro Universitário Metodista Ipa	Centro Universitário Metodista Ipa	https://ensaiosclinicos.gov.br/rg/RBR-7nkxkf	<NULL>	To have functional independence through the Barthel index; Be over 65 years of age; Cognition above 30 points in the mini mental state examination, any gender	against absolute and relative indications for the six-minute walk test; limiting orthopedic disorders; fracture in the last six months; indication or previous surgery column; Bracing dependence for locomotion as a wheelchair; walker; Crutches; Flares; uncontrolled hypertension ; indication or thoracic surgery in the last six months; dependence on oxygen therapy and cognitive , auditory or visual changes to limit the understanding of assessments and interventions .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-2ttf8m	Pilates and Dance classes for patients diagnosed with Breast Cancer under treatment in Chemotherapy, Radiotherapy or Hormone therapy: Project MoveMama	Not yet recruiting	Intervention	2017-09-13	<NULL>	<NULL>	1373	Pilates and Dance to Breast Cancer patients undergoing treatment: MoveMama Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Fundação Universidade do Estado de Santa Catarina - UDESC	Fundação Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-2ttf8m	<NULL>	Patients older than 18 years; Diagnosis of clinical stage I to III of breast cancer; Being in the period of adjuvant treatment with chemotherapy, radiotherapy or hormone therapy; And receive the release of the oncologist responsible for the practice of physical activity, as well as the Physical Therapy Sector of CEPON.	Patients that present some orthopedic or neurological limitation that prevents the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7chtrj	Cognitive therapy in the treatment of resistant social anxiety disorder	Recruiting	Intervention	2017-09-13	<NULL>	<NULL>	1374	Augmenting pharmacological treatment of treatment-resistant social anxiety disorder with cognitive therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Instituto de Psiquiatria da UFRJ - IPUB	Instituto D'Or	https://ensaiosclinicos.gov.br/rg/RBR-7chtrj	<NULL>	A current principal diagnosis of social anxiety disorder by DSM-5 criteria; A history of at least one unsuccessful adequate pharmacological treatment trials, operationalized as lack of response Clinical Global Impression-improvement scale (CGI-I)  greater than or equal to 3, to at least 10 weeks of (i) SSRIs or venlafaxine at adequate dosage; with or without (ii) benzodiazepines (e.g. clonazepam 2 mg/day); A total score on the Liebowitz Social Anxiety Scale (LSAS) of 50 or greater; Man and woman with age of at least 18 years.	Pregnancy, lactation, and women of childbearing potential without accepted forms of contraception; Psychotic disorders, bipolar disorder, mental retardation, a recent history of alcohol or substance abuse or dependence; Severe organic medical disorder; Concurrent use of other psychotropic medications than detailed in inclusion criteria; Current or recent significant suicidality; Any concurrent psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-9n35t4	Early Mobility Protocol to neurological inpatients	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	1375	Developing an Early Mobility Protocol to neurological patients in the wards of hucff	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho - HUCFF	https://ensaiosclinicos.gov.br/rg/RBR-9n35t4	<NULL>	systolic blood pressure between 90 and 160 mmHg, heart rate between 40 and 130 beats per minute (bpm), respiratory rate between 10 and 40 breaths per minute, peripheral oxygen saturation &gt;90%	Mecanical Ventilation in Controlled Mode; Need for Vasopressors; Recent Myocardial infarction; Acute Fracture in Lower Limbs; Fracture with instability of spine; Platelets &lt; 20 000; Hematocrit &lt; 25%; Hemoglobin &lt; 7 g/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-43byv6	Effects of  Electrostimulation at Skin Regions that Correspond to Acupunture Points on the Heart Rate Control of Healthy Subjects	Recruiting	Intervention	2017-09-15	<NULL>	<NULL>	1376	Effects of Transcutaneous Electrostimulation at Acupuncture Points on the Autonomic Balance of Healthy Subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Estado do Rio de Janeiro	Universidade Federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-43byv6	<NULL>	Individuals of both sexes, between the ages of 18 and 30, who declare themselves to be healthy (absence of known chronic or acute pathologies) will be considered for the study.	Age greater than 30 and younger than 18 years, pregnancy, presence of cardiac pacemaker or intermittent cardiodesfibrillator, auditory devices, skull trauma, brain injury, status epilepticus, tetanus, chronic liver disease, chronic kidney disease, patients in use Of Sulfonylurea or Glibenclamide, or who have already undergone previous cardiac surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7ktr6r	Treatment protocol of exercises for pain in the lumbar region	Recruitment completed	Intervention	2017-09-15	<NULL>	<NULL>	1377	Treatment protocol of exercises for chronic  lumbar pain, comparison between assisted group  x not-assisted group	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Centro de Traumato-Ortopedia do Esporte	Centro de Traumato-Ortopedia do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-7ktr6r	<NULL>	Patients between 18 and 65 years of age with chronic low back pain who have completed the free Term informed consent	Individuals undergoing previous surgical procedures of the spine or with clinical symptoms of neural compression. Patients with any other pathology that could cause referred pain in the spine or any specific cause of pain; such as fractures; tumor or infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-5nvrwm	Balance Exercises in Fall Prevention and quality of living in elderly	Recruitment completed	Intervention	2017-09-18	<NULL>	<NULL>	1378	Balance Exercises Circuit on fall prevention and quality of living in elderly: a follow-up estudy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Departamento de Saúde Coletiva	Faculdade de Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-5nvrwm	<NULL>	Healthy elderly volunteers; age between 60 and 80 years; both genders; sedentary.	Physical or functional conditions that could be aggravated as a result of the proposed activities or that could prevent full participation in the study such as dementia, Alzheimer’s disease, Parkinson’s disease, use of prosthesis in the lower limbs, and participation in regular and targeted physical activity.Age less than 60 years and over 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-56q7h9	The Effect of Grape Seed and Grapefruit Seed Extracts on Bone Regeneration: randomized clinical trial	Data analysis completed	Intervention	2017-09-18	<NULL>	<NULL>	1379	Effect of Natural Compounds on Bone Regeneration: a human study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-28	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-56q7h9	<NULL>	adult male patients, non-restorable tooth and installation of oral implants; need for implant-supported crown	History of chemotherapy or radiotherapy of the head and neck; previous periodontal disease; alcohol abuse; history of bisphosphonate therapy; diabetic patients who were decompensated; smokers; any contraindication to oral surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6gt3rt	Facilitated Tucking during Peripheral Venipuncture in hospitalized preterm infants	Data analysis completed	Intervention	2017-09-18	<NULL>	<NULL>	1380	The use of Facilitated Tucking Peripheral Venous Puncture in hospitalized neonates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-06	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6gt3rt	<NULL>	Premature newborns with gestational age 32-36 weeks and 6 days; Newborn requiring venous blood;	Neonates with neurologic, cardiac and gastrointestinal malformations; Neonates using medicines that interfere with hemodynamic parameters (Dobutamine, Dopamine, Fentanyl, Midazolam, Diazepam, Caffeine Citrate, Aminophylline, Chloral Hydrate and Ranitidine); Peripheral venipuncture in the cephalic region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-78jkbb	Study of the Effects of Surface Electrical Stimulation in Women with spine cord injuries and Urinary Incontinence	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1381	Study of urinary and bladder abnormalities prevalent in women with non-traumatic diseases of the spinal cord and comparative analysis of the conservative therapeutic approach with the techniques of sacral and tibial nervous eletroestimulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-24	Hospital Geral de Fortaleza HGF	Universidade Federal de Minas Gerais UFMG	https://ensaiosclinicos.gov.br/rg/RBR-78jkbb	<NULL>	Women with demyelinating disease attended at the Neurology outpatient clinic of Fortaleza General Hospital who report symptoms of the urgency type to urinate; Losing urine before reaching the bathroom; Go often to the bathroom; Raise the night to urinate; Age greater than or equal to 18 years; Present in the expanded scale of the state of disability of kurtzke score less than 6.5 points; Not being a virgin.	Male; pregnant women; Virgins; Disorder of language or senses that makes it impossible to understand the therapy to be used; Women with expanded state score of kurtzke incapacity greater than 6.5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-7kss24	Impact of capoeira lessons on cognition of children from 06 to 12 years	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1382	Impact of capoeira lessons in the executive functions of children from 06 to 12 years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-7kss24	<NULL>	healthy children; both genders; from 8 to 12 years; literate.	children with learning disorder; attention deficit hyperactivity disorder; intellectual disability; hearing impaired: visual impairment without correction; who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-5jx29r	Evaluation of restorations performed with two glass ionomer cements on temporary teeth.	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1383	Randomized clinical trial of two high viscosity´s restorative Glass Ionomer Cements used in deciduous molars.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Metropolitana de Santos (UNIMES)	Universidade Metropolitana de Santos (UNIMES)	https://ensaiosclinicos.gov.br/rg/RBR-5jx29r	<NULL>	Healthy child from 05 to 08 years old, without systemic alteration; good behavior; Presenting clinically at least two deciduous molars with dentin caries lesion involving only the occlusal, with direct vision and access, without clinical and radiographic signs and symptoms of pulp involvement.	Child with systemic impairment. Non-contributory behavior. Black, Class II, III or IV type carious lesion. Clinically: carious lesion involving enamel, deficient restorations, small carious lesions in dentin (no access for hand excavators), occult caries lesions, sign and / or clinical symptom of pulp involvement, clinical impossibility of restoration. Radiographically: evidence of pulp involvement, carious lesion extending beyond 2/3 of the dentin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-26kgx5	Effect of chromium consumption in HIV patients with abnormal distribution of body fat	Recruitment completed	Intervention	2017-09-19	<NULL>	<NULL>	1384	Effect of chromium supplementation in HIV patients with lipodystrophy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-25	Faculdade de Medicina de Ribeirão Preto USP	Faculdade de Medicina de Ribeirão Preto USP	https://ensaiosclinicos.gov.br/rg/RBR-26kgx5	<NULL>	Men; adult; HIV-positive; ART for at least 6 months; with lipodystrophy.	Previous thyroidectomy or thyroid dysfunction; in use of glucocorticoids at the last year; with signs or symptoms of opportunistic infections; hepatic dysfunction; renal dysfunction; using insulin or hypoglycemic; taking vitamin and or mineral supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-4rtyfm	Composite resins restorations in posterior teeth using in association with two materials: bulk-fill resin or glass ionomer cement.	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1385	Class II restorations evaluation using bulk-fill resin base or glass ionomer cement: Clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4rtyfm	<NULL>	older than 18 years; both genders; needed for Class II restorations due to the presence of carious lesions and / or due to replacement of preexisting restorations with caries recurrence, loss or fracture of restorations; presence of at least three vital dental elements to be restored by each participant whose opposing teeth are present; good general health; acceptable level of oral hygiene; presence of at least 20 teeth under occlusion.	high risk of caries and / or periodontal disease; holders of removable or orthodontic appliances; patients with bruxism and / or xerostomia; cavities which, after preparation, do not have a minimum depth of 4 mm in the proximal box; pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-8w8yh8	Comparative analysis of anti-inflammatory effect of two drugs administered previously surgery to remove wisdom teeth	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1386	Comparative analysis of anti-inflammatory effect of a corticosteroid and a NSAID administered previously to impacted thrid molars surgery: a randomized double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-17	Universidade de Pernambuco, Campus Arcoverde	Universidade de Pernambuco, Campus Arcoverde	https://ensaiosclinicos.gov.br/rg/RBR-8w8yh8	<NULL>	Individuals of both sexes; Aging between 18 e 35 years in the moment of the intervetion; Have indication for surgical removal of  four third molars with total or parcial bony impaction; Have the right and left third molars in similar position according to Pell and Gregory and Winter classifications; Be at least 10 days without using any drug that influences significantly the inflammatory response; and agree with the terms of the research.	Have any disease or systemic condition that contraindicate the surgical procedure; Continually use drugs that influences significantly the inflammatory response; Be in gestation or lactation; Show signals and symptons of inflammation or infection related to third molars at the moment of the intervention; Total duration of the surgical procedure longer than 90 minutes in any of the interventions; Have, during the surgical procedure, any unusual complication that results in the break of the protocol estabilished in the material and methods of the study; and refuse to participate of the data collection procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-65zy7x	Clinical evaluation of a dental adhesive containing copper nanoparticles in composite resin restorations in dental lesions near the gingiva	Recruitment completed	Intervention	2017-09-19	<NULL>	<NULL>	1387	Clinical evaluation of a universal adhesive system containing copper nanoparticles in composite resin restorations in non-carious cervical lesions: triple blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-65zy7x	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9hyh9w	Individual guidelines for changing the attitude of breastfeeding in mothers with newborns hospitalized	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1388	Breastfeeding: impact of a program of guidance individuals on the attitude of breastfeeding of puerperae with newborns hospitalized in an intermediate care unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9hyh9w	<NULL>	Postpartum women who agreed to participate in the study, by signing the Informed Consent Form; Puerperas with newborns hospitalized immediately after delivery at the research unit with gestational age greater than thirty-four weeks; Birth weight greater than one thousand five hundred grams; Absence of changes that prevent breastfeeding.	Multiple gestation; Newborn with diagnosis or suspicion of congenital heart diseases, syndromes or congenital malformations; Genitoras requiring hospitalization in an intensive care unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-53bmfx	Effectiveness of Acupuncture as treatment on Headache	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1389	Effectiveness of Acupuncture as auxiliary treatment on Chronic Headache	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-53bmfx	<NULL>	Patients between 18 and 60 years old were included in the study; female; with chronic headache using medication prescribed by the Pain Specialist; who had never undergone acupuncture treatment.	Patients with decompensated and/or severe arterial hypertension; those who were diagnosed with secondary headache and were under treatment with physical therapy or other non-drug auxiliary treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-7cwtgg	Quality of postoperative recovery in women undergoing gallbladder surgeries	Not yet recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1390	Postoperative quality of recovery in women undergoing cholecystectomies: a randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-02	Faculdade de Medicina de Jundiaí	Hospital Regional de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-7cwtgg	<NULL>	Women; age between 18 and 65 years; ASA I or II physical condition; to undergo laparoscopic cholecystectomy performed electively and indicated due to cholelithiasis.	Patients who refuse to participate in the research; who are taking any sedative, opioid or sleep inducing drugs; Patients who refuse to participate in the research; who are taking any sedative, opioid or sleep inducing drugs; who have a history of allergy to any drug to be used in the study; carriers of severe obesity; pregnant or breastfeeding; carriers of pathologies that cause some cognitive deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9m7cqq	Analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	Recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1391	In vivo analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade de Medicina de Botucatu Unesp	Faculdade de Ciências Farmacêuticas USP	https://ensaiosclinicos.gov.br/rg/RBR-9m7cqq	<NULL>	Age above 60 years old; clinical stability characterized by the absence of exacerbation in the last three months and regular use of medication including long-term home oxygen therapy.	Use of antioxidant supplements; use of systemic corticosteroids in the last three months; the presence of other respiratory diseases;  diagnose of other NCDs such as diabetes mellitus II, cancer, severe heart failure, kidney or liver; patients with more than 15% or 200 mL increase in FEV1 after bronchodilator administration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-3gz8hc	A Clinical Trial of Spectrila® in Adult Subjects with Newly Diagnosed Acute Lymphoblastic Leukaemia	Not yet recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1392	"A Clinical Phase II Trial to Describe Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of Spectrila® with the
Pharmaceutical Active Ingredient Recombinant L-Asparaginase in Adult Subjects with Newly Diagnosed Acute B-Cell Lymphoblastic Leukaemia"	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-12-15	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3gz8hc	<NULL>	Subjects with newly diagnosed pathologically confirmed acute B-cell lymphoblastic leukaemia; Female or male higher or equal to 18 years of age; Eligible for treatment and treated according to the underlying treatment protocol BRALL 2014; Written informed consent given freely; Subject expresses his/her understanding of the trial procedures and willingness to abide by them during the course of the trial; Female subjects of child-bearing potential must use a highly effective method of contraception (pearl index less than 1%)  in combination with a second method of contraception during the trial and for at least 3 months after Spectrila discontinuation; Men should use effective contraceptive measures and be advised to not father a child while receiving ASNase.	"Pre-treatment with any ASNase preparation; 
Hypersensitivity to the active substance, Escherichia coli-ASNase preparation or to any of the excipients; Pancreatitis at the time of treatment initiation or history of pancreatitis; Pre-existing known coagulopathy; Severe liver function impairment; History of serious haemorrhage or serious thrombosis; Other current malignancies; Uncontrolled active infection; Evidence of infection with the human immunodeficiency virus, hepatitis B or C, human T-lymphotropic virus type I and
II, syphilis or Chagas disease (American trypanosomiasis); Pregnancy as verified by a positive pregnancy test or nursing woman; Active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely; Evidence or suspicion that the subject might not comply with the requirements of the trial protocol; Evidence or suspicion that the subject is unwilling or unable to
understand the information given to him/her within the informed consent procedure; Any other factor which in the investigator’s opinion is likely to compromise the subject’s ability to participate in the trial; The subject is an employee or direct relative of an employee of the contract research organisation (CRO) involved in the trial,
the trial site or medac; The subject is imprisoned or is lawfully kept in an institution; The subject has participated within 3 months before screening or plans to participate in a clinical trial (except the underlying treatment protocol BRALL 2014); Previous participation in this clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-5mv4y9	Extensive evaluation of the effects of low-power laser on mandibular movements and swelling after maxillary surgery	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1393	Longitudinal evaluation effects of phototherapy with low-power laser in mandibular movements, pain and edema after orthognathic surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Hopsital Santa Catarina	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5mv4y9	<NULL>	Individuals submitted to bimaxilar orthognathic surgery with mentoplasty; Removal of the third molars to the minimum of six months before the surgery; Both genders; Regardless race; Age range between 18 and 40 years.	Individuals submitted only to monomaxillary surgery or surgeries without chin surgery; Individuals with temporomandibular joint dysfunctions; Rupture in the inferior alveolar nerve during the surgical procedure; Unwanted fractures; Mandibular surgery with the execution time above 2:30 h; Unstable mandibular fixation; Allergy to standardized anti-inflammatories and analgesics; Postoperative infection; Individuals who did not cooperate with the laser therapy protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9trcpn	Pilates in the posture and balance of the elderly	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	1394	Analysis of the effect of the pilates method on the postural profile and balance of the elderly community in the neighborhood of Pedro in Teresina - PI	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Associação Teresinense de Ensino	Associação Teresinense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-9trcpn	<NULL>	Age of 60 to 80; female; be resident of the São Pedro neighborhood in Teresina Piauí; be a participant in the extension group Roses of the Evening of the Faculty of St Augustine; absence of osteoarticular disease; not practice physical activity	Spondylolisthesis; spondylolisthesis; bone tuberculosis; huge discrepancies of the lower limbs; metallic prostheses of the knee and hip; presence of labyrinth disorders; participants who did not agree with the research objectives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-7qhddz	The Effect of the Laser Application Before and After Fatigue, in Pain Control and Muscle Damage	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1395	"Photobiomodulation Before and After the femoral quadriceps Fatigue Protocol of
Healthy patients in Pain Control and Muscle Damage: a controlled study
randomized double blind"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-08	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qhddz	<NULL>	Healthy male; 18 and 30 years of age; BMI less than or equal to 27 kg / m2; classified as active and performing physical activities at least five times a week, totaling a minimum of 150 minutes per week according to criteria Established by the International Physical Activity Questionnaire (IPAC).	Musculoskeletal lesions in the last six months affecting the joints of the hip, knee or ankle; neurological lesions that make it impossible to perform fatigue protocol; skin irritations in the area of irradiation on photobiomodulation; smokers; malignant neoplasm; use of any type of nutritional supplement or agent Pharmacological.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9znxcq	Strength training as a complementary treatment in the immune system of people living with HIV/Aids: clinical and randomized trial.	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1396	"Effect between two methods of interval training of high intensity in the process
Inflammation and subclinical atherosclerosis of people living with HIV/Aids: a study
Double blind clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Universidade Federal de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9znxcq	<NULL>	Individuals receiving the first antiretroviral regimen; undetectable viral load in the last six months; CD4+cell counts&gt; 200 u/L in the last six months; use of antiretroviral therapy for more than six months; low risk of ischemic cardiac event Framingham; To have an adequate physical condition.	Disorders of locomotion; mental disorders, except anxiety and depression; continuous use of depressant drugs of the Central Nervous System (CNS), except benzodiazepine, use of statins, use of corticosteroids; use of non-hormonal anti-inflammatory drugs; pregnancy or breastfeeding; severe renal and / or hepatic and / or cardiopulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-7xzvpc	Effects of Elastic Bandage on the change of the position of the scapula and humeral retroversion of the shoulder in youth of handball	Recruitment completed	Intervention	2017-09-21	<NULL>	<NULL>	1397	Effects of Kinesio Taping on Scapular Dyskinesia, Umeral Retroversion and Shoulder Symptomatology in Handball Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7xzvpc	<NULL>	Young female handball players; age between 15 and 25 years; with stable vital signs and normal physical conditions.	"Young people with previous history of shoulder joint injury in the last six months;
Previously submitted to surgery on upper limbs or neck;
Presence of generalized ligament laxity;
Presence of an allergic reaction to the bandage or adhesive tape;
Presence of neurological or systemic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-26wscq	Exercises in nursing professionals with Low Back Pain	Recruitment completed	Intervention	2017-09-21	<NULL>	<NULL>	1398	Lumbopelvic Stabilization Exercises in nursing professionals with Non-specific Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	AESC - Associação Educadora São Carlos	AESC - Associação Educadora São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-26wscq	<NULL>	Professionals of the nursing sector; both sexes; pain equal to or greater than four; age between 18 and 50 years; ability to perform exercises.	History of neurological, infectious and systemic diseases; Lower back pain; Pregnancy or suspected pregnancy; Professionals with a history of previous lumbar spine surgery; Present two consecutive faults or alternating tees; Any co-operative dysfunction or inability to respond to the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-5bphrt	Analysis of dental biofilm&apos;s proteins and its relation with the effectiveness of the resin infiltration technique to prevent tooth breakdown in children who present molar-incisor hypomineralization (MIH)	Recruiting	Intervention	2017-09-22	<NULL>	<NULL>	1399	Proteomal analysis of dental biofilm and its association with the effectiveness of the resin infiltration technique for the prevention of post-eruptive breakdown in children with molar-incisor hypomineralization (MIH)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Faculdade de Ciências da Saúde - Universidade de Brasília	Secretaria de Educação do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-5bphrt	<NULL>	Children with 8 years old; with good general health; with the first four permanent molars erupted, with at least one being affected by molar-incisive hypomineralization (MIH); who sign the terms of assent; whose parents have signed the TCLEs.	Children who have used any antifungal drug therapy or topical oropharyngeal antimicrobial medications for at least three months prior to collection; children outside the established age range; children with systemic, motor or psychological impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-27fvry	To verify the influence of moderate or strenuous Physical Activity and Sedentary lifestyle on the rate of Urinary Incontinence in young women who had never had children	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	1400	Influence of Physical Activity levels and Sedentary behavior in the prevalence of Urinary Incontinence in young nuliparous women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade do estado de Santa Catarina/UDESC	Faculdade de Engenharia da Univerasidade do Porto (FEUP)	https://ensaiosclinicos.gov.br/rg/RBR-27fvry	<NULL>	Be female; aging between 18 and 40 years; nulliparous; sedentary behaviour (did not practice regular physical activity); and had urinary incontinence and / or sexual dysfunction.	Women with a history of diabetes mellitus; chronic pelvic pain; previous pregnancy; and history of gynecological surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-6s8qm5	Telephone nursing assistance to control Nausea and Vomiting after outpatient Anticancer Chemotherapy	Recruitment completed	Intervention	2017-09-27	<NULL>	<NULL>	1401	Telephone Assistance and Monitoring for Nausea and Vomiting control associated with outpatient Antineoplastic Chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-08	Instituto do Câncer do Ceará	Hospital Haroldo Juaçaba	https://ensaiosclinicos.gov.br/rg/RBR-6s8qm5	<NULL>	Patients aged 18 years and over, patients receiving moderate chemotherapy and high emetogenic potential (intravenous busulfan, carboplatin, combination of doxorubicin or epirubicin with cyclophosphamide, carmustine, cisplatin, intravenous cyclophosphamide, cytarabine (dose&gt; 200mg / m²);Dacarbazine; Dactinomycin; Doxorubicin; Epirubicin (dose&gt; 90 mg / m², ifosfamide (dose&gt; 2 g / m²), mechlorethamine, melphalan, methotrexate (dose&gt; 250 mg / m²), streptozocin, oxaliplatin)	Cancer of the gastrointestinal tract; Drug therapy with tramadol; Patients who drink alcohol during the treatment period; Patients undergoing daily chemotherapy regimens, these being given individually or in combination therapy, intravenous or oral routes (busulfan, cyclophosphamide, etoposide, procarbazine)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-4mywtr	Knowledge of the Nursing Team about Basic Life Support in Pre and Post-Qualification Babies	Recruiting	Intervention	2017-09-27	<NULL>	<NULL>	1402	Knowledge of the nursing team about Basic Life Support for infants - pre and post Training in Service: a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4mywtr	<NULL>	Staff of the nursing team volunteers; Nursing technicians and nurses; Day and night shift attendants and day laborers; Both genders; Age between 18 and 70 years; Regularly hired in the Institution scenario and crowded in the neonatal intermediate unit; Neonatal intensive care unit; Unit of pediatrics; Center of normal birth and unit of female hospitalization.	Staff of the nursing team volunteers; Nursing technicians and full-time nurses in the neonatal intermediate unit; Neonatal intensive care unit; Unit of pediatrics; Normal delivery center and female inpatient unit that are absent; graduates; As well as transferred from units or dismissed in the period of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-3k9vxy	The Pilates method in the elderly	Recruitment completed	Intervention	2016-12-29	<NULL>	<NULL>	1403	Effect of the Pilates Method in the elderly with pains.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Filosofia e Ciências (FFC)- Universidade Estadual Paulista &apos;Júlio de Mesquita Filho&apos; (UNESP)	Faculdade de Filosofia e Ciências (FFC)- Universidade Estadual Paulista 'Júlio de Mesquita Filho' (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-3k9vxy	<NULL>	Volunteers with chronic músculoesquelética pain; female; aged between 60 and 75 years.	Neurological symptoms; discrepancy between limbs greater than two centimeters; ankylosing spondylitis; rheumatoid arthritis; disc herniation; tumor; infection; vertebral fracture; cauda equina syndrome; cardiovascular or cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-2wjncp	Continued treatment with darunavir/ritonavir in children and adolescents aged 3 years and above with HIV-1	Recruitment completed	Intervention	2017-09-28	<NULL>	<NULL>	1404	Continued access to Darunavir/Ritonavir (DRV/RTV) in HIV-1 infected children and adolescents aged 3 years and above	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-10-13	Hospital Geral de Nova Iguaçu	Janssen Research and Development*	https://ensaiosclinicos.gov.br/rg/RBR-2wjncp	<NULL>	"Male or female subjects, aged 3 years and above.Subject has completed the TMC114-C212, TMC114-TiDP29-C228 or TMC114-TiDP29-
C230 trial, and in the opinion of the investigator continues to receive benefit from using Darunavir. Darunavir is not commercially available for the pediatric subject, is not reimbursed, or cannot be
accessed through another source in the region the subject is living in. Subject  and the parent(s) or legal representative(s)have signed the Informed Consent Form voluntarily."	"Any condition which, in the opinion of the investigator, could compromise subjects’ safety or adherence to treatment with Darunavir. Any active clinically significant disease or findings of medical history, laboratory or physical examination that, in the opinion of the investigator, would compromise subjects’ safety during treatment with Darunavir. Previously demonstrated clinically significant allergy or hypersensitivity to Darunavir or to Ritonavir. Pregnant or breastfeeding female subjects. Female subject of childbearing potential without use of effective birth control methods or
not willing to continue practicing these birth control methods for at least 30 days after the end of the treatment period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9svwrv	Effect of a Green Tea&apos;s Catechin on Appetite in healthy women	Recruitment completed	Intervention	2017-09-28	<NULL>	<NULL>	1405	Effects of Acute Supplementation with Epigalocatequine 3 Galate (EGCG) on Appetite&apos;s Modulation in healthy women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Universidade Federal de Goiás	Gustavo Duarte Pimentel	https://ensaiosclinicos.gov.br/rg/RBR-9svwrv	<NULL>	The study population will be composed of healthy; eutrophic women (BMI between 18.5 kg/m2 and 24.9 kg/m2; aged between 20 and 30 years.	Women with a BMI of less than 18.5 kg m2; BMI greater than 24.9 kg/m2; carriers of immune diseases; use of immunosuppressive drugs; clinical diagnosis of diabetes; thyroid dysfunction; chronic kidney disease or liver disease; to have  had  bariatric procedure prior to the study; Are chronic alcoholics; Use medications that modulate hormonal functions (eg, contraceptive); medicines that affect appetite; medicines that affect body weight (eg, inhibitors) in the last 12 months; Have participated in any food restriction program; have been using nutritional supplements in the last 12 months; Have a feverish state in the weeks of the research; Have not followed the stipulated protocol for data collection; have refused to carry out any of the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-6pvvdb	Physical exercises decrease stress in nurses	Data analysis completed	Intervention	2017-09-28	<NULL>	<NULL>	1406	Exercise and Stress	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Faculdade de Ciências Médicas da Universidade do Estado do Rio de Janeiro	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6pvvdb	<NULL>	Men and women professionals of Nursing of the State Institute of the Brain Paulo Niemeyer; age between 18 and 60 years.	Clinical impediments to exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9qg3bg	Effects of water aerobics on body measurements, fat percentage, quality of life, postural balance and daily activities in the elderly	Data analysis completed	Intervention	2017-09-28	<NULL>	<NULL>	1407	Influence of a Balance development program on elderly community residents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal Fluminense	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9qg3bg	<NULL>	Non-participants of any regular physical activity program in the six months prior to the survey.	Elderly people with disabilities that impair the body balance, as blindness or uncorrected visual impairment, and/or hearing impairment. Parkinson&apos;s, Alzheimer&apos;s or dementia diagnosed by a doctor. Lower limb prostheses. Against medical indication for exercising. Cognitive impairment detected by the Mini Mental (score below 24).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-3z474z	Post traumatic stress disorder and neurons degeneration, stress leading to accelerated aging.	Recruiting	Intervention	2017-09-28	<NULL>	<NULL>	1408	Post traumatic stress disorder and neuroprogression. Trauma and stress increasing alostatic load and accelerating the aging process.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Escola Paulista de Medicina	Departamento de psiquiatria da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z474z	<NULL>	Women; between 18-45 years old; raped in the last six months; evaluated at Perola Byington Hospital specialized service; with post traumatic stress disorder.	Menopause; mental retardation; clinical and neurological diseases not under control; schizophrenia; bipolar disorder; drug or alcohol dependence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-4k7zh3	Application of ice in the oral cavity of people using chemotherapy for cancers with 5-fluorouracil: a randomized clinical trial	Recruiting	Intervention	2017-09-29	<NULL>	<NULL>	1409	Cryotherapy applied to people using antineoplastic chemotherapy with  5-fluorouracil: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Ceará	Centro Regional Integrado de Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-4k7zh3	<NULL>	Patients with cancer receiving chemotherapy 5-fluorouracil (5-FU) bolus as part of chemotherapy protocol at the beginning of treatment (any cycle); Patients over the age of 18;Both sexes;Patients with scores on the Glasgow scale equal to 15.	Be in radiotherapy in the head region or concomitant esophagus to chemotherapy;Possess smoking habits and alcohol during the research;Have a history of tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-66qtvq	Can Esophageal Varices in children be predicted without the performance of Endoscopy?	Recruitment completed	Observational	2017-09-29	<NULL>	<NULL>	1410	Can Esophageal Varices in children be predicted without the performance of Upper Digestive Endoscopy?	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	Unesp-Universidade Estadual Julio de Mesquita-Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-66qtvq	<NULL>	patients with up to 15 years of age; in follow-up by portal hypertension of any etiology; that are not in use of beta-blocker;to agree to the free and informed consent of the parents or guardians and the of 12 years.	the use of beta-blocker, previous high gastrointestinal bleeding, having undergone portosystemic shunts or TIPS (intra-hepatic transjugular shunt), liver transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-443bqc	The influence of music on pain and physiological responses in sedated patients.	Data analysis completed	Intervention	2017-10-02	<NULL>	<NULL>	1411	The influence of music therapy on pain and physiological responses in patients of an Adult Intensive Care Unit of the Federal District.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-443bqc	<NULL>	Patients of both genders; Age above 18 years; With continuous sedation; In use of mechanical ventilation by means of an orotracheal tube; With stable hemodynamics; Preserved auditory acuity.	Patients in blood transfusion; during dialysis; in use of vasoactive drugs; in use of a mattress or thermal blanket; if sedation was switched off; extubated; death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-6b8hcc	Laser Treatment for pain relief in Cesarean operative wound	Recruitment completed	Intervention	2017-10-03	<NULL>	<NULL>	1412	Effect of Low Level Laser Therapy for pain relief in the Cesarean Section	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-19	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6b8hcc	<NULL>	8 to 10 hours postpartum cesarean; Pain on the numerical scale of pain greater or equal 3 in the region of the cesarean incision; Without clinical or obstetrical intercurrences; Without infectious process; Receive the same drug treatment (anti-inflammatory, analgesic and old) with equal interval of ingestion.	Women who do not accept to perform the intervention with the low intensity laser; Puerpera with difficulty of communication and expression; Volunteers who present clinical and obstetric instability during the data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-2vrqrn	Effectiveness of Automatic Brushes in Down Syndrome Patients	Data analysis completed	Intervention	2017-10-04	<NULL>	<NULL>	1413	Brush effectiveness compared to manual brush without dental biofilm control with down syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-03	Universidade Federal do Piauí	Secretaria de Educação do Estado do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2vrqrn	<NULL>	Individuals with medical diagnosis of Down Syndrome; In the age group from 4 to 14 years of age; Linked to the local study center; Have in the dental arch 1 tooth or more in each sextant.	Individuals with systemic alterations or psychological condition that make participation in the study impracticable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-653hw7	Physiotherapeutic exercise during hemodialysis in people with Chronic Renal Insufficiency	Recruitment completed	Intervention	2017-10-05	<NULL>	<NULL>	1414	Physiotherapeutic intervention in individuals with Chronic Renal Insufficiency submitted to intradialytic physiotherapeutic treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-653hw7	<NULL>	Clinical diagnosis of chronic renal failure (CRF); Regular hemodialysis for at least 3 months; Do not have diagnostically disabling osteo-myo-articular, respiratory or cardiovascular dysfunctions; Have sufficient level of understanding to understand the exercises to be performed.	Restless Hemodynamics at rest characterized by systolic blood pressure &gt; 180 mmHg or &lt;90 mmHg; Diastolic Blood Pressure &gt; 100 mmHg or &lt;50 mmHg; Heart Rate &gt; 120 bpm or &lt;60 bpm; muscle disorders; hospital internment; change in hemodialysis site; adherence to the protocol less than 70%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9wnkk7	Effects of Photobiomodulation on anterior serratio muscle, Electromyographic Fatigue, and conjunct action of shoulder muscles	Recruiting	Intervention	2017-10-07	<NULL>	<NULL>	1415	Effects of Photobiomodulation on anterior serratus muscle and electromyographic indicators of Fatigue and synergism of shoulder muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-9wnkk7	<NULL>	Age between 20 and 30 years; full and non-painful active range of motion of the shoulder; elbow and wrist joints; Body mass index (BMI) less than or equal to 27; Considered not very active by the International Physical Activity Questionnaire (IPAQ); have not been in training for at least three months.	Musculoskeletal dysfunction in shoulder, wrist and hand elbow; Weakness of the anterior serratus muscle; winged scapula; history of trauma or previous surgery in the upper extremities; subluxation of the glenohumeral joint; rheumatic, degenerative or neurological disease; patients with diabetes mellitus and fibromyalgia; patients with uncontrolled hypertension; regular intake of drugs and dietary supplements; Fitzpatrick Type Scale Type V and Type VI classification and physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-333g2h	Trial of the safety and efficacy of Dalbavancin versus Active Comparator in children with Skin Infections	Recruiting	Intervention	2017-10-09	<NULL>	<NULL>	1416	"A phase 3, multicenter, open-label, randomized, comparator
controlled trial of the safety and efficacy of Dalbavancin
versus Active Comparator in pediatric subjects with Acute
Bacterial Skin and Skin Structure Infections"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-10-31	Associação Hospitalar de Proteção à Infância Dr. Raul Carneiro	Inc Research Br Serviços de Pesquisa Clínica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-333g2h	<NULL>	"Male or female. Age between 3 months and 17 years. Clinical compatible with infection caused or suspected to be caused by bacteria. Fever, Low leukocytes, cutaneous abscess (pus on the skin), accompanied by redness, edema and/or induration, surgical or traumatic wound infection.
Having: drainage / secretion of pus; fluctuation, localized heat / heat; sensitivity to palpation and / or swelling / induration."	"Clinically significant renal impairment; Clinically significant hepatic impairment; treatment with an investigational drug within 30 days preceding the first dose of
study medication; Patients with low blood arterial pressure; Receipt of antibiotic within 14 days prior to randomization;  An exception is allowed for patients
receiving a single dose of antibacterial drug; Patients with necrotizing fasciitis, or deep-seated infections that would require more than two weeks of antibiotics and and infections caused by fungi, in combination with a bacterial pathogen; Venous catheter entry site infection; Infections involving diabetic foot ulceration, perirectal abscess or a decubitus ulcer; Patient with an infected device, even if the device is removed; Patients whose skin infection is the result of having sustained full or partial thickness burns;
Patients with uncomplicated skin infections such as superficial/simple
cellulitis/erysipelas, impetiginous lesion, furuncle, or simple abscess that only requires surgical drainage for cure.
Concomitant condition requiring any antibiotic therapy that would interfere with the assessment of study drug for the condition under study. Sickle cell anemia
Cystic fibrosis. Anticipated need of antibiotic therapy for longer than 14 days. Patients who are placed in a hyperbaric chamber as adjunctive therapy for the ABSSSI. More than two surgical interventions for the skin infection, or patients who are expected to require more than two such interventions.
Medical conditions in which chronic inflammation may preclude assessment of
clinical response to therapy even after successful treatment (e.g., chronic stasis
dermatitis of the lower extremity)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9c73cm	Effect of electromyographic biofeedback associated with vocal therapy in dysphonic women	Recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1417	Effect of electromyographic biofeedback associated with vocal therapy in the larynx, voice and muscular electrical activity of dysphonic women: controlled, randomized and blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Faculdade de Odontologia de Bauru/Universidade de São Paulo	Faculdade de Odontologia de Bauru/Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9c73cm	<NULL>	Aged between 18 and 45 years will be included; women; presence of behavioral dysphonia	Report a history of neurological or syndromic diseases will be excluded; Hearing dysfunction; Laryngeal and/or pulmonary surgery; Speech and/or otorhinolaryngological treatment prior to vocal problems; Evidence of behavioral dysphonia of psychogenic origin; Smoking; Participants who do not complete the face-to-face sessions of the proposed interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-2rt2wy	Effect of Ginger on controlling blood sugar and fat levels in people with Type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1418	Effect of Ginger (Zingiber Officinale) on glycemic and lipemic control of people with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-23	Universidade Estadual do Piauí	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2rt2wy	<NULL>	Volunteers with type 2 diabetes for at least 2 years;both sexes;age between 20 and 80 years;be enrolled and monitored in the E-SUS AB system;treatment with oral antidiabetics;have glycated hemoglobin between 7 and 10%.	Smoking volunteers;history of alcohol abuse; gestation and lactation;consumption of ginger in the usual diet;cognitive alterations;diagnosis of diabetes pathologies or complications such as heart, renal, gastrointestinal and hepatic heart diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-34fr3y	Effects of mobile application use on adherence to treatment after Angioplasty.	Recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1419	Effects of use mobile application on adherence to treatment after Percutaneous Coronary Intervention: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade do Vale do Rio dos Sinos - UNISINOS	Associação Pró-Ensino em Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34fr3y	<NULL>	Have performed percutaneous coronary intervention with stent implantation (regardless of the number of stents and type) for treatment of stable coronary artery disease or for acute event; own smartphone (Android or iOS platform); of both sexes; be over 40 years old.	Patients with motor and / or neurological difficulty to use the smartphone; inability to respond to the questionnaire due to motor and / or neurological difficulty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9h77k7	Effects of Ear Acupuncture and Cupping Therapy with glasses on Back Pain	Not yet recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1420	Effects of Auricular Acupuncture and Cupping Therapy on Chronic Back Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9h77k7	<NULL>	Age (between 18 and 80 years); orientation in time, space and person; presence of chronic pain in the vertebral column for three months or more, of any origin; self-report of pain intensity bigger or equal 4, and availability of time for submission to treatment sessions.	Infection, inflammation or injury in the ear; use of piercing (except normal earring); allergy to metal or micropore; decreased skin turgor, skin lesions or diseases in the dorsal region; treatments with anticoagulant; use of other energy therapies (massage, herbal medicine, reiki, floral therapy) up to three months prior to the study; physiotherapy treatment concomitant with the proposed interventions; continuous use of medication for pain relief; neurological, psychiatric or rheumatic disease; pregnancy; breastfeeding; and not respond to three attempts of contact made by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7k6pfb	Effects of high intensity of exercise  in female athletes	Not yet recruiting	Intervention	2016-03-02	<NULL>	<NULL>	1421	"The peripheral muscular  oxygenation and ventilatory during dynamic exercise of high
intensity players from football: A randomized clinical trial of the effects of
respiratory muscle training in improving exercise tolerance"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-18	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7k6pfb	<NULL>	Twenty healthy volunteers; female; non-smoking; aged between 18 and 25 years; athletes	Cardiac diagnosis; renal; hepatic; pulmonary; neurological; psychiatric; hematological or metabolic disorders; that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-43mg87	Effect of Sublingual Supplementation with Resveratrol in patients with Renal Disease	Not yet recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1422	Effect of Supplementation of Resveratrol Sublingual on Oxidative And Inflammatory Stress Markers in Hemodialysis Patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-43mg87	<NULL>	Patients of both sexes; over the age of 19; diagnosis of chronic kidney disease and who have been on a regular hemodialysis program for at least 3 months, since this is the time used to confirm the chronicity of renal disease	Patients with a history of hypersensitivity to resveratrol will be excluded from the study; patients with food allergy containing resveratrol;cancer patients; with acute renal failure; in use of anti-inflammatory drugs; use of omega 3 supplementation; bedridden patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5mzzd4	Effects of Brazilian nut consumption on the expression of factors that regulate inflammation in patients with coronary artery disease	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1423	Effects of Brazil nut supplementation (Bertholletia excelsa H.B.K.) in Nrf2 and NFkB expression in coronary arterial disease patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5mzzd4	<NULL>	Will be included in the study: men and women over 18 and non-smokers.	Patients with autoimmune and infectious diseases, pregnant and lactating women; Cancer and AIDS; Patients taking catabolic drugs and antioxidant vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9p22nj	Telephone intervention for the control of Fatigue in Cancer patients undergoing Radiotherapy	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1424	Telephone intervention for the management of Fatigue in Cancer patients submitted to Radiotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-15	Escola de Saúde Pública do Ceará	Centro Regional Integrado de Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-9p22nj	<NULL>	Age equal or superior to 18 years; to have cognitive ability to follow the guidelines and to respond to Piper&apos;s fatigue scale through the application of Mental State Minisease (MMSE); score above 60% on the Karnofsky scale; to have a telephone (landline or cellular) to follow the teaching program.	Patients who reported difficulties in receiving telephone calls; and patients taking antidepressants or with chronic pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9qpn2b	Effectiveness Mobilization with movement and Tape of Mulligan in ankle Functional Unstable: a randomized study	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1425	Effectiveness MWM e Tape of  Mulligan in ankles Functional Unstable: a randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Salgado de Oliveira	Universidade Nacional de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-9qpn2b	<NULL>	"Informed Consent Term.
Both sexes.
Age between 18-50 years.
History of ankle sprain injury.
Score below 17 on the CAIT questionnaire.
Body mass less than 25%."	"Disabling pain in any joint of the lower limb including the ankle.
They had already undergone surgery on the lower limb.
History of lower limb fracture.
That they were allergic to the components of the different types of bandage.
Any other contraindication to physical exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-4gzbqn	Effect of the Hydrotherapy physical function and quality of life in older people with Chronic Diseases	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1426	Effectiveness of the Aquatic Physiotherapy program in functional fitness and quality of life in older people with Non-Transmissible Chronic Diseases	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-4gzbqn	<NULL>	Elderly volunteers in the age group between 60 and 80 years old; with hypertension; diabetes; osteoarthritis; with good adaptation to the liquid environment.	Volunteers who present cardiorespiratory; musculoskeletal; neuromuscular dysfunctions that prevent the aquatic intervention program and contraindications of aquatic physiotherapy; such as otitis; hydrophobia; urinary infections and skin lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8nwxh5	Nutrition and Culinary in the Kitchen Intervention Program with university students	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1427	Evaluation of the Cooking Skills Intervention impact on Eating Habits of university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8nwxh5	<NULL>	Being 16 years old or older; being study in the first year of higher education; not living with parents; having a kitchen with basic equipment and utensils available (stove or microwave oven, fridge, cutlery, and pans) to prepare their food; having availability in participating in the cooking classes; signing the Consent Form.	Being study in the distance learning course or postgraduate courses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5t27sb	Effects of Electrical Stimulation in heart Transplant patients	Recruitment completed	Intervention	2017-10-17	<NULL>	<NULL>	1428	Effects of Acupuncture with electrodes in heart Transplant patients	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-5t27sb	<NULL>	Cardiac transplanted patients; older than 18 years; in outpatient follow-up at the National Institute of Cardiology.	Those with cardiac pacing device; intermittent cardio-defibrillator; using hearing aids; carriers of brain injury, patients with status epilepticus; patients with chronic liver disease; patients with chronic kidney disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-69t5jq	Elastic Bandage associated with Low Back Pain Exercises in Nonspecific	Recruitment completed	Intervention	2017-10-18	<NULL>	<NULL>	1429	Kinesio Taping® associated with Lumbopelvic Stabilization Exercises in patients with Cronic non-radicular Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-69t5jq	<NULL>	Patients of both genders; Age between 18 and 60 years; Non-radicular lumbar pain greater than or equal to five in the Visual Analogue Pain Scale for a period greater than three months; Not performing any other type of physiotherapeutic approach for non-radicular lumbar pain at the time of the study; Have signed the Free and Informed Consent Form; Medical referral for physiotherapeutic treatment.	Severe spinal pathologies (fracture, tumors, and inflammatory conditions such as ankylosing spondylitis); Previous surgery in the lumbar region; Involvement of the nerve root (disc herniation and spondylolisthesis with neurological involvement of the spine, stenosis and others); Against general indication for the use of KT (allergy or intolerance to the use of the bandage); Severe cardiorespiratory disease; pregnancy; Non-attendance in three consecutive visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5vwj4y	"Effect of a Fluoride Varnish on the Prevention of Dental Caries in permanent teeth:
randomized clinical study of 18 months"	Recruitment completed	Intervention	2017-10-18	<NULL>	<NULL>	1430	Effect of a TiF4 Varnish in the Prevention and Remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Universidade de São Paulo	Faculdade de Odontologia de Bauru - FOB/USP	https://ensaiosclinicos.gov.br/rg/RBR-5vwj4y	<NULL>	Signature of parents or guardians, the Informed consent. Present active white spot lesions (scale 1 Nyvad et al., 2003) on smooth surfaces of at least two teeth in the initial clinical examination.	users of orthodontic appliances; That participated in another clinical trial within 3 months prior to the selection or subjected to professional fluoride application in the last 6 months; treatment with antibiotics or some other type of medicine (with chronic diseases);with periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7cnj5g	Association between Aerobic Capacity and Sleep in Elderly	Data analysis completed	Intervention	2016-06-16	<NULL>	<NULL>	1431	Association between Cardiorespiratory fitness and Sleep in Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal da Paraíba	Pulmonar Diagnóstico	https://ensaiosclinicos.gov.br/rg/RBR-7cnj5g	<NULL>	Aged 60 years or older; Men and women; body mass index (BMI) between 18.5 and 29.9 kg / m²; Diagnosed with hypertension; No use of beta-blockers; Considered irregularly active (IPAQ adapted for the elderly).	Smokers / recent ex-smokers (&lt;6 months); Diabetes mellitus; restrictive respiratory diseases / obstructive and / or cardiovascular	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8ns8pb	Caring for type 2 diabetic people. Outcomes of the assessment of an Educational Program	Recruitment completed	Intervention	2017-10-19	<NULL>	<NULL>	1432	Nurse caring for adult type 2 diabetic people. What are the outcomes in lifestyle?	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade de Lisboa	Universidade de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-8ns8pb	<NULL>	"Type 2 Diabetes
HbA1c over 7.5%"	Cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-88kqmx	Use of two different Desensitizing Gels to avoid Sensitivity to Tooth Whitening	Data analysis completed	Intervention	2017-10-19	<NULL>	<NULL>	1433	Use of different Desensitizing Gels on Sensitivity to Cleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-88kqmx	<NULL>	patients aged 18 years and older; of both sexes; at least six upper anterior teeth free of caries and restorations on the vestibular face; at least one central or canine incisor showing coloration A2 or darker, evaluated in comparison to a visual value-oriented color scale of the teeth.	users of fixed orthodontic appliances; patients with periodontal disease; pregnant or lactating women; severe intrinsic stains on the teeth (spots on the use of tetracycline, fluorosis and depolluted teeth); consuming any Anti-inflammatory and antioxidant drugs; using desensitizing dentifrice and participants with previous history of SD or any associated pathology (bruxism, gingival recession; non-carious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8gzwzp	The evaluation of the nurse performed at the home of children and adolescents with Severe Asthma.	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1434	Nursing Home Visit in the treatment of children and adolescents with Severe Asthma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-08	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8gzwzp	<NULL>	To be patients of the Multidisciplinary Center for Patients with Asthma of Difficult Control; be between 3 and 18 years of age; be residents of Belo Horizonte or metropolitan region.	Residing outside Belo Horizonte and metropolitan áreas; having other pathologies such as cystic fibrosis; ciliary dyskinesia; tuberculosis; bronchiolitis obliterans post infectious; interstitial pneumopathies, congenital pulmonary and bronchial tree malformations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8ykyws	Effects of physical exercise and vitamin D supplementation on muscle mass of  hemodialysis patients	Recruitment completed	Intervention	2015-06-25	<NULL>	<NULL>	1435	Effects of physical training and vitamin D supplementation on muscle mass of  hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-30	Faculdade de Medicina de Botucatu	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8ykyws	<NULL>	Individuals older than 18 years; with chronic kidney disease on dialysis for a period greater than or equal to three months; classified as sedentary or irregularly active according to the International Physical Activity Questionnaire (IPAQ); do not have contraindications to physical activity; and accept and sign the Informed Consent.	Individuals unable to understand the procedures performed; prior diagnosis of coronary artery disease; positive exercise test for cardiac ischemia; patients classified as active or very active based on the International Physical Activity Questionnaire; Patients who have suffered stroke; patients with cancer, liver failure, chronic infection or acute in activity;  uncontrolled hypertension (&gt; 160 mmHg systolic or &gt; 100 mmHg diastolic); Use of medications that affect body composition, such as corticosteroids and antiretroviral therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-37hrf2	Rhizophora mangle (red mango) cream on skin wound healing	Recruiting	Intervention	2017-10-23	<NULL>	<NULL>	1436	Rhizophora mangle cream on skin wound healing. randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Centro de Ciencias da Saúde da Universidade Federal de Pernambuco	Fundação Santa Luzia	https://ensaiosclinicos.gov.br/rg/RBR-37hrf2	<NULL>	Volunteers who will undergo plastic surgery of the upper eyelids at the Santa Luzia Foundation; Both genders; Age between 18 and 65 years; Normal preoperative blood and cardiac tests	Volunteer smokers; Diagnosis of infection in the eyelids; Diagnosis of cancer; Diagnosis of diabetes; Diagnosis of renal, hepatic, hematological or immune pathologies; Diagnosis of obesity; Use of immunosuppressive or corticoid medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-243gf6	Effect of a controlled release system of doxycycline for control of periodontal disease	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1437	Effect of a controlled release system of doxycycline for control of periodontal disease: randomized double masking clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-243gf6	<NULL>	Individuals presenting chronic periodontitis (AAP-1999); individuals with contralateral quadrants containing at least one molar with presence of sites with probing depth 5 mm, clinical insertion level 6 mm and bleeding at probing; over 18 years.	Presence of periapical and pulpal alterations; presence of gingivitis and acute periodontal conditions (abscesses and acute necrotizing periodontitis); presence of candidosis and changes in the mucosa; allergy to the components of gels and periodontal dressings; presence of systemic diseases (cardiovascular, blood dyscrasias, immunodeficiencies, transplanted, diabetes, osteoporosis, nephropathies, hepatopathies); need for antibiotic prophylaxis before periodontal treatment; use of systemic antibiotics, chemotherapeutics of controlled or continuous use and others that may interfere with the inflammatory process or have adverse effects directly in the periodontium in the last 6 months; pregnancy and contraceptive users during the study and during the previous three months or lactation; smokers; surgical or non-surgical periodontal treatment in the last 6 months; treatment with chlorhexidine mouthwash 0.12% or other topical chemical agent in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-22fy6t	Clinical Trial of Lurbinectedin / Doxorubicin versus Cyclophosphamide, Doxorubicin and Vincristine or Topotecan as Treatment in Patients with Lung Cancer.	Not yet recruiting	Intervention	2017-10-23	<NULL>	<NULL>	1438	Phase III Randomized Clinical Trial of Lurbinectedin (PM01183)/ Doxorubicin (DOX) versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients with Small-Cell Lung Cancer (SCLC) Who Failed One Prior Platinum-containing Line (ATLANTIS Trial)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital de Caridade de Ijui	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-22fy6t	<NULL>	"Voluntary written informed consent of the patient; Adult patients aged more than 18 years; Diagnosis of limited or extensive stage small cells lung cancer (SCLC);  Small-cell carcinoma of unknown primary site with or without neuroendocrine; ECOG PS lower than 2; Adequate hematological, renal, metabolic and hepatic function in an assessment performed within 7 days (+ 3 day window) of randomization;	At least three weeks since last prior anticancer treatment and recovery to grade less than 1 from any AE related to previous anticancer treatment;	Prior Radiotheraphy (RT): At least four weeks since completion of whole-brain RT (WBRT), at least two weeks since completion of PCI, and to any other site not previously specified; Evidence of non-childbearing status for women of childbearing potential (WOCBP). WOCBP must agree to use a highly effective contraceptive measure up to six weeks after treatment discontinuation."	"More than one prior chemotherapy-containing regimen (including patients re-challenged with same initial regimen); 
Patients who never received any platinum-containing regimen for SCLC treatment; 
Prior treatment with PM01183, topotecan or anthracyclines;
Limited-stage patients who are candidates for local or regional therapy, including PCI, thoracic RT or both, must have been offered that option and completed treatment or refused it prior to randomization;
Impending need for palliative RT or surgery for pathological fractures and/or for medullary compression within four weeks prior to randomization;
Symptomatic, or steroid-requiring, or progressing CNS disease involvement during at least four weeks prior to randomization; 	Concomitant diseases/conditions:
History (within one year prior to randomization) or presence of unstable angina, myocardial infarction, congestive heart failure or clinically significant valvular heart disease;
Symptomatic or uncontrolled arrhythmia despite ongoing treatment;
Patients with any immunodeficiency, including those known to be or have been infected by human immunodeficiency virus (HIV);
Ongoing, treatment-requiring, non-neoplastic chronic liver disease of any origin,	Active infection or increased risk due to external drainages, Intermittent or continuous oxygen requirement within two weeks prior to randomization. Patients with confirmed or suspected diagnosis of diffuse interstitial lung disease (ILD) or pulmonary fibrosis, Patients with a second invasive malignancy treated with chemotherapy and/or RT. Patients with a previous malignancy that was completely resected with curative intention three or more years prior to randomization, and who has been continuously in remission since then will be permitted, Limitation of the patient’s ability to comply with the treatment or to follow the protocol, Documented or suspected invasive fungal infections requiring systemic treatment within 12 weeks of randomization; Pregnant or breast feeding women."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-2t56nz	The Effect of L-arginine in the treatment of Sickle Cell Anemia	Data analysis completed	Intervention	2017-10-24	<NULL>	<NULL>	1439	Double Blind Randomized Trial for L-arginine Effectineness study as a coadjuvante therapeutic protocol in the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2t56nz	<NULL>	Adult patients volunteers between 18 and 80 years with sickle cell anemia; both genders; in use of hydroxiurea from 500mg per day; baseline	Patients who do not have sickle cell anemia; Patients who refuse to participate in the study not signing the ethic term; those who have had transfusional therapy in the last three months; patients using iron chelator and antioxidant vitamins; patients smokers and drinkers; pregnant or with diabetes mellitus or with some picture of renal or hepatic insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-6cs352	Assessment of life habits and health status associated with Fatigue	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1440	Fatigue Management Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-09	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-6cs352	<NULL>	men; adults; alternating shift workers; Vitamin D levels less than 30 ng/mL or less than 75 nmol/L; blood glucose increased; lipid profile increased; blood pressure increased; waist circumference increased	clinical history of malabsorption syndrome, kidney disease, liver or thyroid changes; use of anticonvulsant drugs, steroids, hormones or supplements of vitamins and minerals; altered levels of creatinine, calcium and albumin depending on the kit to be used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-2yfbnp	Inflammation Indicators in Saliva from children and adolescents with Spastic Cerebral Palsy	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1441	Salivary Biomarkers associated with Gingivitis in children and adolescents with Spastic Cerebral Palsy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Cruzeiro do Sul	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-2yfbnp	<NULL>	Will be included in this study  individuals with a medical diagnosis of spastic type CP.	"Will be excluded individuals with progressive or neurodegenerative lesions will be excluded; Individuals with CP who are taking any drug that interferes with salivary secretion such as anticholinergics, neuroleptics or benzodiazepines for at least 72 hours prior to salivary collection; Or have undergone surgical procedures to control the external flow of saliva.
Still, individuals who do not collaborate with the salivary collection have used antibiotics in the last month, present symptoms of fever, flu, body aches or diarrhea, or even an inflammatory condition on the oral mucosa as a cold sore."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-3n2f38	Effect of using a Mobile Application for foot Care of people with Diabetes	Not yet recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1442	Multimedia Application on Mobile Platform to Promote foot Care for people with Diabetes: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Estadual do Ceará - UECE	Universidade Estadual do Ceará - UECE	https://ensaiosclinicos.gov.br/rg/RBR-3n2f38	<NULL>	Be 18 years of age or over; having a medical diagnosis of type 2 diabetes mellitus; be accompanied by the Integrated Diabetes and Hypertension Center; possession of a mobile device for personal use android smartphone; ability and familiarity with application usage.	Persons with apparent diseases and conditions with marked functional dependence; cognitive deficit or any difficulty that impedes the handling of the device and responses to the instrument; and present pre-existing diabetic ulcer. Discontinuity criteria: non-attendance at the study stages; illness or death during the course of the study; giving up and not answering calls. Three attempts of interleaved contacts will be made.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-3vfqfb	Protocol of nursing in the Prehospital Care in the Emergencies and Cardiovascular Emergencies	Not yet recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1443	Therapeutic Nursing Guidelines for Prehospital Clinical Care in Emergencies and Cardiovascular Emergencies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Faculdade de Enfermagem e Medicina Nova Esperança	Hospital Regional Tarcísio de Vasconcelos Maia	https://ensaiosclinicos.gov.br/rg/RBR-3vfqfb	<NULL>	Patients users of the Unified Health System; of both sexes; 18 years of age or older; diagnosed with cardiovascular disease in an emergency and emergency situation.	Will be excluded from the sample: communication barriers; with degenerative neurological diseases; patients who present a surgical plan that influences the follow-up; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-8t2p2m	Effects of Exercise on stationary bicycle in Hemodialysis Patients	Recruitment completed	Intervention	2017-10-26	<NULL>	<NULL>	1444	Effects of intradialitic aerophonal exercise with partial restriction of blood flow in patients in hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Escola Superior de Educação Física/Universidade Federal de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8t2p2m	<NULL>	patients with chronic kidney disease on hemodialysis; 18 years of age or over; both sexes.	With previous diagnosis of coronary artery disease; submitted to mechanical ventilation and hospitalized in the intensive care unit; with musculoskeletal limitation that impedes the performance of the exercise; with cognitive alterations that make it impossible to understand the instructions of the exercises; pregnant women; individuals with a history of deep venous thrombosis; with systolic blood pressure greater than or equal to 180 mmHg or greater diastolic equal to 105 mmHg at rest and resting heart rate greater than or equal to 120 bpm at rest; practitioners of any physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-6n3mw9	The Teaching of Nursing by Realistic Simulation for Palliative Care	Data analysis completed	Intervention	2017-10-26	<NULL>	<NULL>	1445	Use of Realistic Simulation for the teaching of palliative care in nursing: a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6n3mw9	<NULL>	Nursing students volunteers; Regularly enrolled in the fourth, fifth, sixth and seventh periods of the institution&apos;s nursing course; Both genders and over 18 years of age.	Nursing course students who are absent; Licensed in the period of data collection; With irregularity in the enrollment and under 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-8xvwpj	Impact of seats with different ergonomic designs on postural changes, low back pain and cervical pain in dental academics	Data analysis completed	Intervention	2017-10-26	<NULL>	<NULL>	1446	Impact of seats with different ergonomic designs on postural changes, low back pain and cervicalgia in dental academics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Faculdade de Odontologia de Piracicaba- Unicamp	Fundação Hermínio Ometto - Uniararas	https://ensaiosclinicos.gov.br/rg/RBR-8xvwpj	<NULL>	Healthy volunteers; both genders; age between 18 and 50 years; enrolled in disciplines with clinical care of patients.	Volunteers who made continuous use of pain medication; with diagnosis of mental disorders; in clinical and / or physiological conditions that made it impossible to perform the clinical care of patients;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-66dh44	Evaluation of occupational therapy in reducing psychiatric symptoms in individuals with alzheimer&apos;s disease	Recruiting	Intervention	2017-10-27	<NULL>	<NULL>	1447	A randomized controlled trial to evaluate a method of occupational therapy in reducing neuropsychiatric symptoms in individuals with alzheimer&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-18	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66dh44	<NULL>	Individuals over the age of 60 with dementia diagnosis provided by a physician responsible for the treatment.; elderly people with scores of Mini Mental State Examination (MMSE) between 10 and 20 at the time of screening; elderly people with the presence of one or more neuropsychiatric symptoms or behavioral;  elderly people with caregivers for at least four hours per day	"Visual or hearing impairments dysfunctional, or seriously impaired health status, or those who have changed their medications for medical reasons, come to derail the implementation of assistance;
Concomitant psychiatric illness such as schizophrenia, bipolar affective disorder, Depressive Disorder Severe or Recurrent and Alcohol and Drug Addiction, in serious condition or outside clinical control; Inability to come to the Hospital for the interventions; Caregiver with MMSE &lt;25"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-5hncr3	Evaluation of Ethanol Wet Bonding with Cements of Different Degrees of water Affinity and Association	Recruitment completed	Intervention	2017-10-27	<NULL>	<NULL>	1448	Evaluation of Ethanol Wet Bonding with Hydrophilic, Hydrophobic and Association Adhesives: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-08	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Universidade do Estado de São Paulo - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5hncr3	<NULL>	Be at least 18 years old; Both Sex; Non-carious cervical lesion on canine or premolars with at least 1 mm on depth an d cervical-occlusal direction; Antagonist and adjacent tooth.	A medical condition that may interfere with the volunteer safety, during the study period, or allergic reactions to the substances and / or products to be used; Use of removable prostheses which have the clamps resting on the teeth used; Patients with intense parafunctional habits; Present caries lesion in the tooth in question or periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-9h3c2b	Hypotension post-Aquatic Exercise	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1449	Influence of an Aquatic Exercise session on Hemodynamic Responses of Hypertensive elderly subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Institutos Paraibanos de Educação	Institutos Paraibanos de Educação	https://ensaiosclinicos.gov.br/rg/RBR-9h3c2b	<NULL>	Elderly; both genders; physically active; hypertension.	Obesity; Diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-57cqdx	Delayed Reconstructioon of Irradiated Breast  with fat grafting	Recruiting	Intervention	2017-10-29	<NULL>	<NULL>	1450	Delayed breast reconstruction with autologous fat grafting and  implant  after mastectomy and radioterapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	https://ensaiosclinicos.gov.br/rg/RBR-57cqdx	<NULL>	Health woman; age between 21 and 70 year-old; who underwent mastectomy followed by radiotherapy, after at least 6 month of adjuvant treatment conclusion and that wish delayed breast reconstruction; agree breast reconstruction with alloplastic material and autologous tissue; woman in oncological follow-up; agree with all necessary procedures, as well as all outpatient returns and proposed photographies; assign the Consent Form; be free of tumor relapse or any radiological alterations	smoking volunteers; history of alcohol or drug abuse; diagnoses of tumor recurrence or radiological alterations in mammary topography; obesity; loss of segment; cognitive difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-9v37h9	Comparison between two types of Tooth Anesthesia	Recruiting	Intervention	2017-10-30	<NULL>	<NULL>	1451	Efficacy, Latency, Duration and Anesthetic Depth of the traditional Anesthesia method and an In-System Anesthetic Injection without Comfort-In needle in maxillary molars through the Pulp Tester	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-12	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9v37h9	<NULL>	Patients of both sexes; aged between 18 and 30 years; of any ethnic group; marital status; nationality; naturalness; who require local anesthesia to perform class I restorations in the first right (16) and left (26) first molars; also have second right (17) and left (27) molars; no history of pain or trauma; reactive to the electrical stimulus produced by the pulp tester	Patients under 18 years of age or over 30 years; history of alcohol and drug abuse; patient with some pathology that contraindicates the use of local anesthetics; anemia / pregnancy; use of action drugs in the CNS; use of analgesics and anti-inflammatories; pacemaker carrier; use of appliances and orthodontic bands and have no upper molar	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-3yqqgv	The use of intravenous morphine to treat the pain of children undergoing adenoid and tonsil removal surgeries	Data analysis completed	Intervention	2017-09-29	<NULL>	<NULL>	1452	Use of intravenous morphine for postoperative analgesia in children submitted to adenotonsillectomy surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3yqqgv	<NULL>	Exclusive surgeries of tonsillectomies, associated or not with adenoidectomies; age between 3 and 10 years; weight between age-related Z 2 and + 2 scores and considered adequate; physical condition with absence of comorbidities or pathological processes other than those related to the process responsible for the surgery (upper airway infection and / or obstruction); absence of chronic diseases or any deficiencies; schedule the child&apos;s hospital admission on the morning of the day of surgery, since they were planned for 7:30 am; ability of the child to respond to the visual scale of postoperative pain assessment.	Children who were not accompanied by parents or caregivers in the postoperative period; patients in whom there was no follow-up of the standardized anesthetic technique in the study; tonsillectomy performed by warm techniques, such as electrocautery and coblation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-5x5k45	Effect of Fluoride Varnish with Phosphate on Dental Caries	Recruitment completed	Intervention	2017-10-30	<NULL>	<NULL>	1453	Effect of Fluoride Varnish containing Sodium Trimetaphosphate on the progression of Dental Caries in vivo: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Faculdade de Odontologia de Araçatuba - UNESP	Faculdade de Odontologia de Araçatuba - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5x5k45	<NULL>	Volunteers must be aged between 3 to 5 years and 11 to 15 years; must agree to participate in the study through free and informed consent signed by parents or guardians; good general health status; did not participate in any other clinical study in the 3 months prior to selection; do not use any other vehicle with fluoride that is not provided by the study investigators.	Voluntary withdrawal; use of mouthwash or toothpaste not provided by the researchers; failure to comply with the clinical protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-37gdst	Consequences of Dental Absence on Mastication Function of the elderly	Recruitment completed	Intervention	2017-10-31	<NULL>	<NULL>	1454	Consequences of Total Edentulism on Masticatory Function, Masseter Thickness, and Oral Stereognosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-27	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-37gdst	<NULL>	Good general health; Aged between 60 and 85 years old; Totally edentulous in both dental arches, for a minimum period of 6 months, and who do not use one of them, for at least, three months.	Patients with physical or mental impairment, with a presence of parafunctional habits or history of temporomandibular joints or chewing muscles symptomatology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-2335ks	Comparative study between a phytotherapeutic and chlorhexidine on alveolar healing	Data analysis completed	Intervention	2017-10-31	<NULL>	<NULL>	1455	Comparative Study of the Elixir Sanativo and Chlorhexidine on Alveolar Healing	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2335ks	<NULL>	systematically healthy patients; indication for contralateral tooth extraction from extensive carious lesion, periodontal disease or orthodontic indication, without osteotomy or odontosection	uncontrolled systemic pathologies; smokers; alcoholics; pregnant women; patients allergic to one or more drugs used; patients who have used anti-inflammatory drugs or antibiotics in the last 7 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4xytp6	Impact of an Educational and Motivational Intervention on control of Water Consumption by patients on Hemodialysis Treatment	Recruitment completed	Intervention	2017-10-31	<NULL>	<NULL>	1456	Impact of an Educational and Motivational Intervention in the control of Hydraulic Intake of patients in Hemodialysis Treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-03	Escola de Enfermagem de Ribeirão Preto	Hospital de Base de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-4xytp6	<NULL>	18 years of age or older; have terminal chronic kidney disease ; under chronic treatment by hemodialysis to 06 months or more;	Present the outcome of the Mental State Miniexame cognitive assessment unsatisfactory	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4zrmm4	Influence of body fat in energy expenditure of People living with HIV and Aids	Recruitment completed	Observational	2017-10-31	<NULL>	<NULL>	1457	Influence of Brown Adipose Tissue in energetic metabolism of People living with HIV and Aids	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4zrmm4	<NULL>	Adult subjects; male; stable weight for 3 months; body mass index between 18.5 and 29.9 kg / m2; in the case of HIV seropositive patients group using antiretroviral therapy for at least 6 months; T-CD4 cell count greater than 200 cells / mm3; undetectable viral load	Changes of thyroid function; use of glucocorticoids in the last 6 months; use of lipid-lowering drugs; use of oral anti-diabetics; use of beta-blockers; use of benzodiazepines; signs and symptoms of opportunistic diseases in the case of HIV seropositive patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-7bs22c	Effect of foot insoles in patients with rheumatic joint disease	Recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1458	The effect of foot orthoses on balance in  rheumatoid arthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-31	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7bs22c	<NULL>	Patients diagnosed with RA according to the criteria of the American College of Rheumatology of 1987; older than 18 years; stable treatment in the last 3 months; possibility of attending scheduled reassessments; to be literate and able to understand the applied questionnaires and the instructions of the tests of strength and balance; use of shoes that allow the use of insoles	Lower limb involvement due to conditions not associated with rheumatoid arthritis; surgical procedure scheduled for the follow-up period; impairment of cutaneous integrity in the lower limbs; amputation of lower limbs; unbalanced vestibular disease; unbalanced visual disturbance; use of insoles in the last 30 days; use of walking aid for short distances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-2fjmhz	Pain control in breast surgery: analgesia, opioide consumption and inflamatory response evaluation	Recruitment completed	Intervention	2017-10-31	<NULL>	<NULL>	1459	Pain control in breast surgery: analgesia, opioide consumption and inflamatory response evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Hospital Sírio-Libanês	Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-2fjmhz	<NULL>	Patients ASA I and II submitted to radical mastectomy with breast reconstruction	Patients with allergy to local anesthesic, patients with chronic pain previous to surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4c7pd5	Evaluation of the protective response of Human Hapillomavirus (HPV) Vaccine in HIV-positive men in the municipality of Campos dos Goytacazes, Rio de Janeiro, Brazil, 2016-2018	Recruiting	Intervention	2017-10-30	<NULL>	<NULL>	1460	Comparison of antibody responses to the Gardasil® Quadrivalent Human Papillomavirus Vaccine in HIV-positive men in the Municipality of Campos dos Goytacazes, Rio de Janeiro, Brazil, 2016-2018	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-15	Infant Care Serviços medicos LTDA	Infant Care Serviços medicos LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4c7pd5	<NULL>	Man with confirmed serological diagnosis of HIV; men aged 18-45 years; men attended at the Center for Infectious and Parasitic Diseases of the Municipal Secretariat of Campos dos Goytacazes; Accept participation in the study; complete the three doses of the quadrivalent HPV vaccine in the dosage regimen offered	Do not agree to participate in the study; abandonment of research; individuals who do not complete the 3 doses of the vaccine; individuals treated at another infectious disease center	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4f32xy	Team-Based Learning: comparing learning methods in nursing	Data analysis completed	Intervention	2017-06-01	<NULL>	<NULL>	1461	Team-Based Learning: A randomized clinical trial in undergraduate nursing and the construction of educational technology.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-16	Departamento de enfermagem da Unesp	Unesp ( Universidade Estadual Paulista)	https://ensaiosclinicos.gov.br/rg/RBR-4f32xy	<NULL>	The students of the 3rd year of undergraduate nursing; will be included in the study, enrolled in the average 27 students in the discipline of Nursing in Surgical Center, who agree to participate in the study.	Students who are not in class at the time of data collection will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-9cr4b2	Strengthening Training and Blood Flow Restriction to increase hand&apos;s strength	Not yet recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1462	Comparison of different Strengthening protocols associated with Blood Flow Restriction to increase handgrip strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9cr4b2	<NULL>	"Both sexes; with age between 18 and 35 years old; students from Universidade Federal de Santa Catarina - UFSC, Campus Araranguá. 
There will be selected only the participants that are apt to perform the proposed tasks."	Subjects with a forearm injury that may interfere with the muscle integrity; subjects with recent fractures in wrist and finger regions; subjects with upper limb pain for any reason. Participants with obesity, hypertension, cardiopathy; individuals with cognitive deficits; workes with manual tasks; participants that perform regular physical activity; and participants using medications that may interfere with final results of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-95m73t	Influence of Fibrin Clot on Bone Formation within the Maxillary Sinus Cavity after surgery to Lift the Maxillary Sinus Membrane with the use of particulate Bovine Bone	Recruitment completed	Intervention	2017-10-31	<NULL>	<NULL>	1463	Influence of Leukocyte- and Platelet-rich Fibrin (L-PRF) on Bone Regeneration after Maxillary Sinus Augmentation with Bio-Oss®: a radomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista (UNESP)	Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-95m73t	<NULL>	Minimum age of 18 years old; bilateral edentulism in the maxilla posterior region; 5 mm of minimum bone width and up to 4.0 mm of crestal bone height; written informed consent.	Compromised general healthy condition; uncontrolled diabetes; pregnancy; smokers; alcohol and drug abusers; irradiated patients; therapies with bisphosphonates; blood platelet disorders; chronic sinusitis and patients suffering from any pathology in the maxillary sinus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-8qdf7t	Effect of topical Dipyrone application in tooth sensitivity caused from In Office Dental Bleaching	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	1464	Effect of the use of topical Dipyrone in tooth sensitivity resulting from In Office Dental Bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-27	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-8qdf7t	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening, pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology. Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory or who have allergies to Dipyrone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-9z764g	OM-85BV for prevention of respiratory tract infections	Data analysis completed	Intervention	2017-11-01	<NULL>	<NULL>	1465	OM-85BV for prevention of respiratory tract infections: a double-blind, placebo-controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-9z764g	<NULL>	Both female and male children 1 to 5 years old; daycare or preschool attendance; written informed consent signed and dated by a parent or legal guardian in accordance with the ethical standards of the local ethics research committee.	Children diagnosed with asthma, cystic fibrosis, major systemic condition, immune disorders, suspected malabsorption, known allergy to bacterial extracts, major surgery within 3 months of study entry, recent immunosuppressive, immunostimulant or corticosteroid therapy or any other chronic disease that might affect the results; premature babies (less 36 weeks gestation); children participating in other research studies during this project; children who have received OM-85 or any other immunostimulatory or immunosuppressive agents including cyclosporine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-2ypjhv	Genetic monitoring and balance in the redox medical residents occupationally exposed to inhaled anesthetics	Recruitment completed	Observational	2015-06-09	<NULL>	<NULL>	1466	Genetic monitoring and redox balance in resident physicians occupationally exposed to inhaled anesthetics	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-25	Departamento de Anestesiologia	Faculade de Medina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2ypjhv	<NULL>	First year of medical residency in anesthesiologists areas; general surgery; orthopedics; neurosurgery; healthy volunteers; both genders; aged 18 to 35	Have done medical residence in the areas of interest of the study; Carrier malignancy; be more than 35 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4fr2gf	Effects of combined exercises among individuals with radiating low back-related leg pain	Recruiting	Intervention	2017-11-07	<NULL>	<NULL>	1467	Effects of neurodynamic exercises addition to extension-oriented treatment approach among individuals with low back-related leg pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4fr2gf	<NULL>	Eligible patients may be between 18 and 65 years of age; have radiating pain into one leg below the gluteus for at least 12 weeks with low back pain; mild to severe function limitation; positive SLR test; sufficient understanding to describe signs and symptoms and to answer the specific questionnaires.	Patients will be excluded if they be pregnant; have serious spinal pathology; have exercise contra-indications; have history of lumbar surgery; have severe metabolic or cardiovascular pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-5thjgv	Effects of Physical Training on controlling Blood Pressure, Heart Rate, and Inflammation for post-Stroke individuals	Recruitment completed	Intervention	2017-11-07	<NULL>	<NULL>	1468	Effects of Physical Training on Metabolic, Hemodynamic, Autonomic and Inflammatory Parameters of post-Stroke individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade São Judas Tadeu	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5thjgv	<NULL>	Ischemic Stroke after 6 months; sufficient functional capacity to perform daily activities according to the Barthel Scale; age group between 45 and 85 years; both genders; non-smoker; non-alcoholic; sedentary; have not had recent heart surgery; not having pains that make it impossible to do physical activity; have diabetes mellitus and / or controlled hypertension (s); not have chronic obstructive pulmonary disease; not have an orthopedic injury that makes it impossible to perform exercises.	Orthopedic problems that make it impossible to perform exercises; diabetes and / or uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-59xfk3	Evaluation of the effects of dark chocolate with 70% cocoa on cardiovascular health in patients with heart failure	Data analysis completed	Intervention	2017-11-07	<NULL>	<NULL>	1469	Evaluation of the effects of dark chocolate with 70% cocoa on hemodynamic and endothelial parameteres in patients with heart failure	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Programa de Pós Graduação em Ciências Cardiovasculares	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-59xfk3	<NULL>	Sedentary men or women between the ages of 40 and 80;Body mass index (BMI) above 18.5 kg / m 2 for both sexes;Stage 1, 2 and 3 ICC according to the NYHA classification criteria, (1994)	"In use of any dietary supplement you have in your formulation Antioxidant nutrient and chocolate;Creatinine clearance less than 60 mL / min; Smokers or former smokers (less than two years of Smoking);Liver and / or pancreatic disease;Unstable angina pectoris;
Allergy to chocolate or its derivatives;Patients with stage 4 heart failure according to the criterion of NYHA classification (1994); Physical examination with presence of edema;Presence of infectious, autoimmune or immunosuppressive disease; Presence of cardiac cachexia;Presence of hypoalbuminemia;Use of pacemaker;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-7mbrp3	Pharmacists’ knowledge about dispensing of drugs after completing a training course	Data analysis completed	Intervention	2015-04-13	<NULL>	<NULL>	1470	Evaluation of pharmacists’ knowledge about dispensing of drugs after completing a training course	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo	Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mbrp3	<NULL>	"Participants must be registered at the Regional Council of Pharmacy of the state where they work.
According to data from the Federal Council of Pharmacy; Brazil has approximately 70.576 pharmacies that dispense drugs. Whereas each of them must rely on the assistance of at least one pharmacist; the minimum study population is 70.576 professionals.
From this population; the sample target will be 2000 individuals aged at least 18 years. There is no maximum age for the inclusion of individuals."	Not to be updated with the professional documentation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-9jqdgq	Clinical evaluation of the effects of esmolol and magnesium sulfate to avoid tachycardia and arterial hypertension during intubation in surgeries	Recruitment completed	Intervention	2017-11-08	<NULL>	<NULL>	1471	Clinical evaluation of the effects of esmolol and magnesium sulphate on the hemodynamic response to tracheal intubation	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-18	Universidade do Sul de Santa Catarina	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9jqdgq	<NULL>	Functional class I and II patients, according to the American Society of Anesthesiologists (ASA); submitted to elective surgery; of both sexes; aged between 18 and 65 years; who agree to participate in the study	Patients with difficult airway; obesity with BMI&gt; 35; in the use of beta-blockers or calcium channel blockers; with heart rate less than 60 bpm; cardiac arrhythmias, renal dysfunction, airway hyperreactivity, hypersensitivity to esmolol or magnesium sulfate; and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-93wpsf	An Pilates session reduces Blood Pressure in hypertensive patients	Recruitment completed	Intervention	2017-11-09	<NULL>	<NULL>	1472	Acute Blood Pressure behavior after a Pilates session in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-08	Universidade Salgado de Oliveira	Universidade Salgado de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-93wpsf	<NULL>	Prehypertensive and hypertensive volunteers; Both sexes; Nonsmokers, height between 1.57 cm and 1.85 cm; Body weight between 58 kg and 97 kg; Age group from 45 to 67 years.	Volunteers with Diagnosis of cardiovascular, respiratory, metabolic or locomotor diseases; Uncontrolled hypertension (systolic pressure 160 mmHg or diastolic pressure and 105 mmHg at rest); Change of medication; Pilates practitioners for more than two consecutive months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-3vwdms	Effects of physical activity in chronic kidney disease in diabetic origin	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1473	"Effects of a physical rehabilitation program in patients with diabetic nephropathy,
with different types of exercises compared to proteinuria- randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-02	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3vwdms	<NULL>	"Minimum age of 18,;
Patients with chronic kidney disease; diabetic source characterized by albuminuria greater than 300 mg / g creatinine; with a sample of 50 persons."	"Patients who are on dialysis;
History or evidence of angina or myocardial infarction;
Positive Exercise Stress Test for coronary disease;
Cardiac arrhythmias;
Musculoskeletal restrictions that preclude participation;
Hemodynamic instabilities;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-38nbbx	The effect of vibration training of the whole body using vibratory platform in a patient with chronic pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1474	Effect Of Whole Body Vibration Training In Women With Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-38nbbx	<NULL>	Women with confirmed diagnosis of fibromyalgia, according to the criteria of the American College of Rheumatology, aged between 35 and 70 years	voluntárias que apresentarem alguma doença concomitante que possa ser exacerbada pela atividade física; gravidez; limitações ortopédicas; doenças inflamatórias; degenerativa; articulares e respiratória ou doenças cardiovasculares; apresentar alguma doença clinicamente instável; lesão do sistema musculoesquelético; estar em acompanhamento com psiquiatra; realizar algum tipo de atividade física; hérnia aguda; trombose; diabetes; epilepsia; doenças metabólicas ou neuromusculares; lesões ortopédicas e próteses; não conseguirem suportar a intervenção; fizer uso de corticoide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4zzp8b	Identification of optimal amounts of technique to reduce shoulder pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1475	Identification of ideal amounts of suprascapular nerve blocks in adhesive capsulitis - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-30	Faculdade de medicina da Universidade Federal de Goiás	Hospital Ortopédico de Goiania	https://ensaiosclinicos.gov.br/rg/RBR-4zzp8b	<NULL>	Participants older than 18 years of age, both sexes with a maximum age of 60 years with primary adhesive capsulitis disease, in phase I of the disease.	Participants with dislocated shoulder dislocation; Arthrosis of the shoulder; Fractures and previous surgeries; Bilateral and secondary adhesive capsulitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4gzmt4	The use of Aromatherapy for Anxiety in nursing&apos; teachers at public university	Recruitment completed	Intervention	2017-11-14	<NULL>	<NULL>	1476	Aromatherapy for Anxiety in nursing&apos; teachers at public university	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Departamento de Enfermagem da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4gzmt4	<NULL>	Healthy volunteers; both genders; age between 18 and 65 years; working regularly in the sector (Botucatu Medical School and Botucatu Institute of Biosciences); consent to participate in the research by signing the Free and Informed Consent Form; achieve minimum score of 35 points in the State-Trait Anxiety Inventory - State Subscale; olfactory odor of lavender essential oils (Lavandula angustifolia) and ylang-ylang (Canaga odorata); and declare that she is not pregnant.	Loss of follow-up of aromatherapy massage sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-9rcxbq	Evaluation of body fat measurements to predict risk of Heart Disease in HIV-positive patients using Cocktail	Data analysis completed	Observational	2017-11-14	<NULL>	<NULL>	1477	Assessment and proposed cutoffs for adiposity indices to predict Cardiovascular Risk in HIV-infected patients on Antiretroviral Therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-13	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9rcxbq	<NULL>	HIV positive test; age between 18 and 60 years; stable HIV patients (no signs or symptoms of opportunistic infections); use of HAART and stable weight (&lt;10% change during the last year).	presence of edema; thyroid disease; chronic renal insufficiency; pulmonary disease; hepatic alterations; signs or symptoms of opportunistic infections; presence of a pacemaker or a metal prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-42pvd9	Ultrasound as a method of aid in the treatment of patients with musculoskeletal pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1478	Ultrasound as an auxiliary tool in the diagnosis and treatment of patients with Myofascial Pain Syndrome. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Marcos André Nogueira Frasson Filho	https://ensaiosclinicos.gov.br/rg/RBR-42pvd9	<NULL>	Adult participants 18 years of age or older who voluntarily signed the ICC and who have at least one active or latent Trigger Point located in the cervical, lumbar or shoulder region (trapezius, scapula lift , supraspinatus, infraspinatus), with symptoms for at least 3 months and receiving treatment, without alteration in the dosing schedule, for at least 1 month. These patients may not have undergone other invasive procedures for pain control, such as infiltration with local anesthetics of PGs, in the last 30 days.	"Patients with the following clinical conditions will be excluded from the study:
active skin lesions, uncontrolled diabetes mellitus, neurodegenerative diseases,
fibromyalgia, uncontrolled arterial hypertension, known allergy to the local anesthetic
presence of active bacterial infection, use of anticoagulation with
altered coagulogram, patient request to leave the study and those who have low cognitive level and who do not understand the evaluation scales used.
There will be no limitation between genres."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5x4397	The Healing Effect of a Herbal Gel Containing Arrabidaea chica in the Treatment of Mouth Wounds in patients with Head and Neck Cancer	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1479	Arrabidaea chica for Oral Mucositis in patients with Head and Neck Cancer: a Protocol of a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital de Clínicas da Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5x4397	<NULL>	Men and women over 18 years old; squamous cell carcinoma of the head and neck; chemotherapy with cisplatin or carboplatin associated with radiotherapy; signs/symptoms of oral mucositis.	Tumor of a histological type other than carcinoma;  nasopharyngeal tumor;  ulcerative lesions; infections in the oral cavity before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4dpths	The effect of a Pilot Psychological Treatment Program that focuses on thoughts, emotions and behaviors in a sample of Brazilian adolescents with Anorexia Nervosa	Recruitment completed	Intervention	2017-11-16	<NULL>	<NULL>	1480	Effectiveness of a Cognitive Behavioral  Management Pilot Program in a sample of Brazilian adolescents with Anorexia Nervosa	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-04	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-4dpths	<NULL>	Adolescents, boys and girls, aged between 12 and 17 years; diagnosed of Anorexia Nervosa, typical or atypical (DSM-IV-TR, 2002); signed consent form (TALE)and authorization of one of the legal responsible for participation in the research, by signing the consent form (TCLE) regarding those responsible; with significant weight loss, marked by the decrease of at least a percentile below the expected for the age, based on the body mass index (BMI) curve for age, gender and compared to the patient&apos;s weight before disease onset.	Patients who due to physical complications of the eating disorder needed to be hospitalized; those at risk of suicide; with psychiatric comorbidities, at the time of the first evaluation, priority in relation to the eating disorder in terms of treatment; diagnosed with Pervasive Developmental Disorders; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5nct6d	Effects of a Protocol in a Cellular Application for the prescription of Anticoagulants in the public health system in the city of Ijuí/RS	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1481	Evaluation of the Efficacy of a Protocol for patients Anticoagulants of the public health system in the city of Ijuí/RS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-5nct6d	<NULL>	Physicians working in the basic health unit; regardless of gender, age, years of graduation and years in the unit	There are no criteria for physician exclusion; except personal refusal; risk of cross-contamination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-6fp5qt	The effect of Motivational Interview on the self-care of patients with Heart Failure	Not yet recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1482	"The effect of Motivational Interview on the self-care of patients with Heart Failure:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Programa de Pós Graduação em Ciências Cardiovasculares da Universidade Federal Fluminense	Universidad de La Republica	https://ensaiosclinicos.gov.br/rg/RBR-6fp5qt	<NULL>	Patients with a medical diagnosis of HF regardless of etiology; normal or decreased ejection fraction; older than 18 years; with functional classes I-III NYHA; be participating in the clinics in the specialized clinics included in this research.	Patients with cognitive neurological sequelae self-reported or identified during the multidisciplinary consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-9pqqpb	Azithromycin in the treatment of Chronic sinusitis: clinical and biopsy evaluation in a controlled study	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1483	Azithromycin in the treatment of Eosinophilic nasossinusal polypose: clinical and histomorphological analysis in a randomized masked study with placebo	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9pqqpb	<NULL>	Patients with eosinophilic nasosinusal polyposis; above 18 years of age; with a percentage of eosinophils equal to or greater than 40% that at clinical and endoscopic examination do not present evidence of active nasosinusal infection (ex: purulent secretion in nasal fossa)	Patients with non-eosinophilic polyposis; younger than 18 years; such as cystic fibrosis; Kartagener&apos;s syndrome; antrochoanal polyp; eosinophilic nasosinusal polyposis in the presence of infection; and patients who used corticosteroids or antihistamines in the 15 days prior to the study .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-2z3ps4	Effects of recreational football on bone, body fat, strength, agility, walking speed, short-term memory and the ability to think fast in the elderly	Not yet recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1484	Effects of recreational football on body composition, physical abilities and executive functions in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	universidade federal de pernambuco	universidade federal de pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2z3ps4	<NULL>	"Individuals male and female;
Age between 60 and 79 years;
Carriers of controlled hypertension;
Individuals classified as sedentary;
To present a higher score than the criteria established in the test Mini Mental State Examination"	"Absolute contraindication for performing physical exercises.
Living outside the metropolitan area of Recife.
Have some physical amputation that limits exercise"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-6pmz49	A clinical trial using Fluoxetine in patients with Premenstrual Syndrome	Recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1485	"A translational approach of the neurobiological determinants of Premenstrual Syndrome
A clinical trial using Fluoxetine in patients with Premenstrual Syndrome"	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2017-05-01	Hospital das Clínicas de Ribeirão Preto	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-6pmz49	<NULL>	Non pregnant women; 18 to 40 years; fill retrospectivily the criteria for premenstrual syndrome according to the American College of Obstetricians and Gynecology	Continuous use of oral contraceptive or brake between pills less than 7 days; current use of injectable contraceptive (monthly or quarterly); current use of contraceptive implants;  current use of drosperinone; use of hormonal DIU; current daily use of benzodiazepines;  current use of drug or any substance which could interfere with esteroidal and/ or fluoxetine&apos;s metabolism;  currency major depressive episode, current generality anxiety, bipolar disorder, schizophrenia or other psychotic disorders, current obsessive-compulsive disorder, current postraumatic stress disorder, current use of ilicit drugs or alcohol (except current use of tobacco);  mild or severe intelectual disability; migraine (except the headache which occurs only in the premenstrual days); epilepsy; pregnancy; women who are breastfeeding; history of intolerance or severe side effects to fluoxetine; history or current other medical condition which could threaten the volunteer&apos;s safety during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-9xcx69	Sclerotherapy with Ethanolamine Oleate of Oral Vascular Anomalies: What is the Ideal Concentration?	Data analysis completed	Intervention	2017-11-21	<NULL>	<NULL>	1486	Sclerotherapy with 5% Monoethanolamine Oleate Foam in Treatment of Vascular Malformations of the Head and Neck Region: A Case Series	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-02	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9xcx69	<NULL>	Patients with oral vascular anomalies less than 20 mm;diagnosis of based on the Mulliken and Glowacki (1982; indications for treatment of these lesions included pain; growth; swelling; pressure or esthetics.	"oral vascular anomalies larger than 20mm
Lesions that do not have the clinical diagnosis of vascular anamolias.
Patients with a history of allergy to the drugs used."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-97jm74	Risk factors for falls in the elderly: effects of different programs on Perception, Cognition, Clinical and Physical Status	Recruiting	Intervention	2017-11-21	<NULL>	<NULL>	1487	Associated factors with risk for falls in the elderly: effects of different interventions on Perceptual, Cognitive, Clinical and Functional Aspects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade Dom Bosco	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-97jm74	<NULL>	Elderly; 60 years or older; women; pre-fragile	Changes that impede participation in the research; reduced cognitive capacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4t35tk	Evaluation of ultrasound impact on deep venous catheterization in children admitted to the Intensive Care Unit of the Clinical Hospital - Unicamp.	Data analysis completed	Intervention	2017-11-21	<NULL>	<NULL>	1488	Evaluation of ultrasound impact on central venous catheterization in pediatric patients admitted to the Intensive Care Unit of the Clinical Hospital - Unicamp	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Hospital das Clínicas da Universidade Estadual de Campinas	Hospital das Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4t35tk	<NULL>	"Patients aged 28 days to 14 years who required central venous access (at the discretion of the attending physician);
Patients admitted at PICU in the presence of at least one of the researchers"	"Children with internal jugular vein thrombosis;
Children with coagulation disorders;
Children with tracheostomy;
Children who underwent cannulation of veins other than internal jugular veins"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-46wwj7	Effect of Stretching at different intensities on Neuromuscular Responses in adults and the elderly.	Suspended	Intervention	2017-11-21	<NULL>	<NULL>	1489	Effect of Stretching intensity on acute and chronic Neuromuscular Responses in adults and the elderly: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-46wwj7	<NULL>	Young adults between 18 and 30 years of age; aged between 60 and 70 years; male; being able to practice physical activity (identified through PAR-Q); have no history of surgery, fracture and arthritis in the lower limbs; have an active extension range of the right knee of less than 160 °	Use of sedative or tranquilizing medications during the collection period; use of alcoholic beverages 24 hours prior to training sessions or tests; low adherence to training (less than 75% of training sessions); involvement in some stretching exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-95xdzh	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	Recruiting	Intervention	2017-07-13	<NULL>	<NULL>	1490	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-95xdzh	<NULL>	Age above 18 years; literate; with clinical and laboratory diagnosis of gestational diabetes mellitus; with gestational age between 12 and 30 weeks; BMI &lt;/ = 45; sedentary; non-smokers; clinically stable;released by the physician to perform physical activities	"Pregnant women with neurological impairment; Endocrine and metabolic complications
Due to DMG; obstetric complications such as systemic arterial hypertension, placenta previa, among others; Presenting pre-existing diabetes (type 1 or 2); heart disease; non-attendance at evaluation; Have more than 25% of absences to the treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4ndjtp	Effects of Acupuncture for Pain Improvement and Quality of Life in Women with Fibromyalgia	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	1491	Effects of Acupunture at the yanglinquan point (vb-34) on quality of life in women with Fibromialgia: a pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4ndjtp	<NULL>	Be between 18 and 60 years of age; be female; have a clinical diagnosis of Fibromyalgia.	To present lesions, injuries and sensitivity impairment in the skin that makes it impossible to apply the modality; use topical medications in the region of the modality; presence of scars or prostheses in the place that could compromise the insertion of the needle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5fwhf7	Canabidiol in the treatment of sleep disorder associated with Parkinson&apos;s Disease	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1492	Canabidiol in treatment of REM behavior sleep disorder associated with Parkinson&apos;s disease- a double-blind placebo controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5fwhf7	<NULL>	Diagnosis of PD according to criteria of the London Brain Bank in stage 1-3 of the Hoehn and Yahr scale;Over 18 years of age;Diagnosis of RBD according to the criteria of the 3rd edition of the International Classification of Sleep Disorders (CIDS-3);With sufficient severity and frequency to indicate a symptomatic treatment, ie with a frequency of 2 or more episodes per week;That they agree to participate in the study.	In adjustment of antiparkinsonian medications; With diagnosis of dementia; Presenting significant hallucinations (score&gt; 2 in the MDS-UPDRS psychosis item); Introducing delusions; With depression; Without a partner with whom you share your bedroom;With severe or decompensated systemic diseases;With probable mild TCSREM, with sporadic episodes and not clinically significant;Alcoholism or use of illicit drugs;Patients in stage 4-5 of the Hoehn and Yahr scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4hv9rs	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training in people on Hemodialysis	Data analysis completed	Intervention	2015-06-08	<NULL>	<NULL>	1493	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training of the lower limbs in physiological and functional parameters in Hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-09	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4hv9rs	<NULL>	Were included patients with chronic kidney disease on hemodialysis for longer three months and weekly frequency of three times a week;  hemodialysis access by arterio-venous fistula.	Systolic blood pressure greater than 180 mmHg or diastolic blood pressure greater than 120 mmHg,  ischemic heart disease, recent myocardial infarction (less than 6 months), complex ventricular arrhythmia, aortic stenosis, severe metabolic disease, severe anemia and aortic aneurysm; respiratory diseases, neurological or musculoskeletal that compromises the protocol execution; inability to perform any stage of protocol; absence in three consecutives exercise sessions; changes of clinical treatment during study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-2yxy7z	The effect of Art therapy in conjunction with the drug treatment of Depression in the elderly	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	1494	Art Therapy and Depression: Effects of Art Therapy as a Complementary Therapy for the Treatment of Depression in the Elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-18	Hospital das Clínicas da Faculdade de Medicina da USP	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2yxy7z	<NULL>	"Age equal to or greater than 60 years, to be literate,to be female.
Diagnosis of depression.
Being on medication for depression, at the stage of relapse prevention, that is, at the maximum dose desired and with symptoms at most moderate (GDS &lt;10).
Agree to participate in the study and fill out the Informed Consent Form, pursuant to Resolution 196 of the National Health Council.
Have a commitment to participate in the program for a period of 20 weeks."	Dementia, Chemical dependence, clinical degenerative disease or associated with high morbidity and mortality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4wt6fw	Laser in Temporomandibular Disorders	Recruitment completed	Intervention	2017-11-22	<NULL>	<NULL>	1495	Influence of different dosimetry of Low Level Laser Therapy in patients with Temporomandibular Disorders: a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4wt6fw	<NULL>	Patients with diagnosis of Temporomandibular Disorders.	Patients using drugs to control pain; conditions in which the use of laser therapy, such as infection and tumors, is contraindicated; patients using orthodontic appliance or dental prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-33jpyy	Effect of Ginger on reducing nausea and vomiting and on quality of life in patients undergoing Chemotherapy	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1496	Effect of Ginger in the occurrence of nauses and vomiting and on the quality of life in patients submitted to Chemoteraphy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Hospital das Clínicas Universidade Federal de Goiás - GO	Hospital das Clínicas Universidade Federal de Goiás - GO	https://ensaiosclinicos.gov.br/rg/RBR-33jpyy	<NULL>	"Aged between 20 and 80 years;
Individuals apt of swallowing capsules; Individuals with a confirmed diagnosis of cancer, being treated with chemotherapy ; Individuals who have undergone at least one CT cycle with the same chemotherapeutic agent and who have experienced nausea or vomiting  as a result of such treatment; Individuals with platelet counts&gt; 100 000/microliters before the initialcycle."	Individuals with ginger allergy or who have made use of it in the last week; Patients on heparin or other anticoagulant medication or who have some bleeding disorder; Patients submitted to chemoterapy associated radiotherapy during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-3fg9cd	Effect of Strength Training associated with muscular electric current on the structure and function of knee extensor muscles	Data analysis completed	Intervention	2017-11-23	<NULL>	<NULL>	1497	Effect of Strength Training associated with Neuromuscular Electrical Stimulation on a structure and function of knee extensor muscles	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-09	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3fg9cd	<NULL>	Undergraduate and graduate students; healthy; aged between 18 and 35 years.	Volunteers with the presence of any health condition that contraindicates or impairs the performance of high intensity exercises; history of knee surgery; a recent picture of musculoskeletal injuries in the lower limbs; subjects engaged in systematic training programs during the collection period; subjects engaged in lower limb strength training programs within 3 months prior to the study; users of ergogenic supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-9wwstd	Use of the PET-Scan examination in the evaluation of the treatment of patients diagnosed with Head and Neck Cancer	Recruitment completed	Intervention	2017-11-24	<NULL>	<NULL>	1498	Use of 18FDG-PET-CT as a predictor of efficacy for locoregional control and survival in the treatment of Head and Neck Squamous-Cell Carcinoma	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-20	AC Camargo Cancer Center	AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-9wwstd	<NULL>	"Patients diagnosed with locally advanced squamous cell carcinoma of the head and neck; Clinical Stages III, IVa and IVb;
Patients with primary tumors of oral cavity, oropharynx, larynx and hypopharynx;
Patients candidates for curative therapy with induction chemotherapy with the use of 03 drugs (taxanes, platinum and fluoropyrimidine) followed by radiotherapy associated with chemotherapy;"	"Heart disease active or not compensated by treatment, or acute myocardial infarction in the previous 6 months.
Active infection present (at the discretion of the investigator); Concomitant systemic diseases considered serious by the investigator; Another primary neoplasm (except in situ carcinoma of the uterine cervix or adequately treated basal cell carcinoma of the skin); Presence of severe psychiatric illness;
Participation in another experimental drug protocol;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2cfy62	The Influence of Pilates Soil on Separation of the Rectus abdominis muscle in Women in the Climatério	Data analysis completed	Intervention	2017-11-24	<NULL>	<NULL>	1499	The Influence of mat Pilates in the Diastasis of rectus abdominis muscle  in women in Climatory Syndrome:Clinical Trial Randomized Single-blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Universidade Sagrado Coração	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2cfy62	<NULL>	Women; Climacteric Syndrome; Abdominal Dystopia.	TUrinary Tract Infections; Neurological Diseases; Osteomyoarticular Dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-4pn2wb	Open randomized trial of the application of remote ischemic preconditioning in breast cancer patients undergoing chemotherapy.	Recruitment completed	Intervention	2017-11-24	<NULL>	<NULL>	1500	Biochemical evaluation of the application of ischemic remote preconditioning in patients with breast cancer in chemotherapeutic treatment containing anthracyclines.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Medicina do ABC (FMABC)	Faculdade de Medicina do ABC (FMABC)	https://ensaiosclinicos.gov.br/rg/RBR-4pn2wb	<NULL>	Sign the informed consent form prior to any study procedure; histologically proven breast cancer for chemotherapy with anthracyclics for neoadjuvant or adjuvant treatment; women; older than 18 years; Estimated life expectancy over six months.	"Uncontrolled active infection with significant clinical impairment of ventricular ejection fraction (LVEF assessed by echocardiogram should be above the lower limit of normal
respective study center); severe cardiac valvulopathy; myocardial infarction; unstable angina pectoris; uncontrolled hypertension or uncontrolled arrhythmias up to six months prior to admission to the study; anterior or concomitant chemotherapy for previous treatment of breast cancer; bilateral mastectomy; active and known drug dependence, including alcoholism; history of positivity for the hepatitis B surface antigen, hepatitis C virus or HIV; woman in breastfeeding phase; a woman of childbearing age who is not consenting to the effective
Birth control methods (eg, sterilization, withdrawal, birth control pills, Depo-Provera injections or
contraceptive implants) during treatment; not be available to complete all necessary procedures for study visits; history or evidence of any clinically significant condition or other disorder or illness that may hinder the evaluation of procedures."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-8sx73k	The effects of intensive therapy on the performance of day-to-day activities in post-stroke individuals	Data analysis completed	Intervention	2017-11-24	<NULL>	<NULL>	1501	The effects of constraint induced movement therapy on the functionality and occupations of individuals after stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-24	Associação de Assistência à Criança Deficiente	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8sx73k	<NULL>	older than 18 years; medical diagnosis of stroke with more than 6 months of injury; clinically stable; asymmetry in the functional use of the upper limbs, determined by the motor activity log scale, quantity subscale with value less than 3; classified as grade 2 or 3 according to the presence of active motor function of the affected upper limb according to the functional level scale of the University of Alabama research group; be able to perform the first four items of the wolf motor functional test; have agreed and signed the Free and Informed Consent Form.	pain that interferes with therapy and home activities; more than two consecutive absences during the protocol; participants who do not comply with the proposed protocol of each group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-6pswj7	Intranasal Azelastine and Fluticasone combination in the treatment of adolescents with Allergic Rhinitis	Recruiting	Intervention	2017-11-27	<NULL>	<NULL>	1502	Intranasal Azelastine and Fluticasone combination in the treatment of adolescents with difficult to treat Allergic Rhinitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Hospital São Paulo - Universidade Federal de São Paulo	Hospital São Paulo - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pswj7	<NULL>	Adolescents between 12 and 18 years old; both genders; difficult to control moderate-severe persistent allergic rhinitis diagnosis; positive cutaneous immediate hypersensitivity test or specific serum IgE to inhalant allergens	Uncontrolled asthma; significant anatomical defects of the upper airway; systemic disease cognitive deficits; upper airways infection in the last 3 weeks; in use of systemic corticosteroid (last 30 days); in use of specific immunotherapy and immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-89rt6v	Warming Program to Prevent Injuries in Basketball Athletes	Not yet recruiting	Intervention	2017-11-27	<NULL>	<NULL>	1503	Warming Program to Prevent Injuries in Basketball Athletes:Cluster Randomised Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89rt6v	<NULL>	As inclusion criterion were established; healthy volunteers; both genders; that carried out at least 4 trainings per week; in addition to 15 to 30 matches per season.	As an exclusion criterion; athletes with some musculoskeletal injury were established prior to the beginning of the study; which prevented the performance of the injury prevention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3bkshg	Correlation between post-surgery urine bleeding degree for prostatic increase and surgery outcomes, evaluated by a new scale of urine bleeding	Recruiting	Observational	2017-11-28	<NULL>	<NULL>	1504	Correlation between post-surgery hematuria degree for benign prostatic hyperplasia and intra and perioperative outcomes, evaluated by a new hematuria scale	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Hospital Brigadeiro UGA V-SP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bkshg	<NULL>	Patients undergoing Benign Prostatic Hyperplasia surgery; any age.	Prostate cancer; Bladder lithiasis; Bladder cancer; Anticoagulants use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-4zvpwb	Comparison of Physiotherapeutic treatments for urine leakage	Data analysis completed	Intervention	2017-11-27	<NULL>	<NULL>	1505	Comparison of the Pilates Mat Method with Perineal Exercises in the treatment of Stress Urinary Incontinence and on Pelvic Floor Muscle Function in women between the ages of 40 and 65	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Faculdade de medicina de Marilia	Faculdade de medicina de Marilia	https://ensaiosclinicos.gov.br/rg/RBR-4zvpwb	<NULL>	Multiparous women in the age group of 40 to 65 years; to present stress urinary incontinence; sign the Informed Consent Form	Prior physical therapy treatment for incontinence urinary stress, or any type of structured and planned physical activity during the study period; already had some surgery of the urinary tract; diagnosis of urinary tract infection, cystitis or genital prolapse; being pregnant; women who could not, even with all the researcher&apos;s attempts at awareness, contract the pelvic floor musculature correctly during the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-8w27x5	Role of fibroblast growth factor 23 (FGF2) in Bone Disease in increased urine calcium loss	Data analysis completed	Observational	2017-12-01	<NULL>	<NULL>	1506	Role of the Fifroblastic growth factor 23 (FGF2) in the Bone Disease in Idiopathic Hypercalciuria	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-14	Faculdade de Medicina da Universidade Federal de Minas Gerais	Children's Mercy Hospital	https://ensaiosclinicos.gov.br/rg/RBR-8w27x5	<NULL>	Pediatric patients; both genders; with diagnosis of Idiopathic Hypercalciuria; age between 3 and 21 years; with diurnal and nocturnal urinary sphincter control.	Pregnant adolescents; patients with nephrocalcinosis; chronic immobilization; hypercalcemia; history of malignancy; excessive intake of calcium and vitamin D; hyperuricemia; prolonged corticoterapia; renal tubular diseases; use of drugs that interfere with calcium metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3t83b5	The effect of Natural Latex Membrane on the Closure of the Palate Wound. A Randomized Controlled Clinical Trial.	Recruiting	Intervention	2017-12-01	<NULL>	<NULL>	1507	The effect of Natural Latex Membrane on the Healing of the Donor Site of the Free Gingival Graft. A Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3t83b5	<NULL>	Age between 18 and 60 years old; Presence of less than 2 mm of keratinized gingiva associated with teeth with association of a shallow vestibule or high insertion of a brides in the vestibular region of lower incisors; Present inadequate oral hygiene in the region or report of hygiene difficulty; Probing depht up to 3mm; Class I or II gingival recessions (Miller, 1985); Present good systemic health.	Smokers and former smokers; Diabetics; Presence of chronic or aggressive periodontitis; Patients who use medicinal products that alter the connective tissue metabolism; Patients who were chronically anti-inflammatories and antibiotics users; Bruxism; Ethilics; Chemical dependents; Pregnant; History of radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-5cgb4g	Comportamento do P300 em pacientes usuários de implante coclear com eletroestimulação unilateral	Recruitment completed	Intervention	2017-12-01	<NULL>	<NULL>	1508	Long Latency Auditory Evoked Potentials (P300) outcomes in  patients with unilateral cochlear implants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5cgb4g	<NULL>	Patients with post-lingual hearing loss undergoing cochlear implant surgery	prelingual hearing loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-9dvpr4	Effectiveness of Exercise in Water on physical and functional performance in people with Chronic Back Pain	Data analysis completed	Intervention	2017-12-01	<NULL>	<NULL>	1509	Effectiveness of Aquapilates on physical and functional performance in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9dvpr4	<NULL>	"Age of 50 to 70 years;
Present non-specific low back pain for more than 3 months;
Have not undergone any surgery in the spine or other surgeries that make the exercises impossible;
Do not present any infection or neoplasms;"	"Individuals who had surgery on the spine;
Have heart failure or any other heart disease;
Chlorine allergy;
Hydrophobia;
Absence of sphincter control;
Neurological disorders;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3xfyhh	Comparison of the amount of air expelled by elderly women before and after respiratory exercises	Data analysis completed	Intervention	2017-12-06	<NULL>	<NULL>	1510	Comparison of the Expiratory Flow Peak among elderly women before and after respiratory exercises	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Presidente Antônio Carlos	Universidade Presidente Antônio Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3xfyhh	<NULL>	Elderly cooperatives; with good cognition; conscious; carriers of heart; metabolic; renal and hepatic diseases; obese; and sedentary women; who answered the Cardiovascular Risk Stratified Questionnaire and who agreed to the Free and Informed Consent Form.	Age less than 65 and greater than 85 years; with high cognitive deficit; tracheostomized; smokers; patients with respiratory and neurological diseases; chauffeured; bedridden; with dementia and that they exposed any conditions that prevented them to carry out the proposed exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2624r4	Assessment of the health of elderly and young people who exercise	Recruiting	Intervention	2017-12-06	<NULL>	<NULL>	1511	Cell health of elderly and elderly people involved in programs resistance training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-14	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-2624r4	<NULL>	Signature of the informed consent form;both genders; over 60 years old; do not have chronic disabling diseases; not be bedridden; institutionalized or hospitalized; have their own mobility	Osteoarticular limitations that impede the execution of the resistance training program; cognitive limitations that prevent the accomplishment of the proposed evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-4vgp58	Physiotherapeutic treatment in chronic obstructive pulmonary disease (copd)	Recruitment completed	Intervention	2017-12-07	<NULL>	<NULL>	1512	Effects of a physiotherapy protocol in patients with chronic obstructive pulmonary disease (COPD)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4vgp58	<NULL>	Volunteers with a proven diagnosis of COPD; not present neurological, cardiovascular and musculoskeletal problems; in addition to loss of cognitive ability, that made it impossible to carry out the evaluation and / or the treatment program.	Neurological, musculoskeletal, cardiovascular, problems; or loss of cognitive ability, making it impossible to perform the assessment and rehabilitation program proposed; not attend two consecutive treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-9zpc27	Study of the cardiac safety of Ibogaine accompanied by psychotherapy in the treatment of addiction to cocaine and crack.	Not yet recruiting	Intervention	2017-12-11	<NULL>	<NULL>	1513	Cocaine and crack Addiction Treatment with Ibogaine	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2018-01-02	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	Prefeitura Municipal de Araguari Prefeitura de Araguari	https://ensaiosclinicos.gov.br/rg/RBR-9zpc27	<NULL>	Age between 18 and 50 years; complete primary education; absence of abnormalities in the evaluation of hemogram, transaminases, gamma-GT, glycemia, hepatitis C, HIV serology, Beta HCG for women, sodium, potassium, magnesium and electrocardiogram with a report attesting the absence of any abnormalities, including prolongation of the QT interval ; cocaine and / or crack dependence, with at least one unsuccessful attempt at treatment; perspective of return to family life; maintenance of abstinence from psychoactive drugs for 30 days between the initial evaluation and the medication session (ascertained by personal reporting and urinalysis of urine at all psychological visits and the day the drug is received); interruption of the use of antidepressants and mood stabilizers, under the guidance of the clinician responsible	Psychotic disorder; schizophrenia and any other psychiatric disorder in which you are in crisis; exams beyond normality; prolonged QT interval demonstrated on the electrocardiogram; pregnancy and breastfeeding; large surgeries in the last 6 months; uncontrolled arterial hypertension; uncontrolled diabetes; myocardial infarction and ventricular arrhythmias; hepatic insufficiency; previous history of accidents with head trauma and loss of consciousness; Alzheimer&apos;s disease; Parkinson&apos;s disease; Being a carrier of epilepsy; motor difficulties that may interfere with writing ability; do not be abstinent from psychoactive drugs for 30 days on the day you receive the drug treatment; be under the influence of antidepressants and mood stabilizing medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2w7mh7	Evaluation of the effect of a Healing Oil on the treatment of Diabetic Foot Cracks	Data analysis completed	Intervention	2017-12-11	<NULL>	<NULL>	1514	Healing Oil for the treatment of Cracks in the Diabetic Foot	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-02	Programa de Pós-Graduação em Patologia da Universidade Federal Fluminense	Programa de Pós-Graduação em Patologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2w7mh7	<NULL>	Type 2 diabetic patients. Adults. Both genders. Registered at ADINF (Associação de Diabéticos de Nova Friburgo, RJ). With xerosis (dry skin). Fissures (cracks) in their feet.	Type 1 diabetic patients. Those with ulcers in their feet. Patient taking medicine for the treatment of the fissures in the skin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2n2gsw	A comparison between the effects of two substances for superficial anesthesia on human gums.	Data analysis completed	Intervention	2017-12-11	<NULL>	<NULL>	1515	Comparative analysis of the effectiveness of  EMLA®( Euthetic Misture of Local Anesthetic) (Prilocaine 2,5% and lidocaine 2,5%) and benzocaine 20% on topical anesthetic in human&apos;s gengival mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-20	Instituto Leão Sampaio de Ensino Universitário Ltda	Instituto Leão Sampaio de Ensino Universitário Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2n2gsw	<NULL>	Healthy volunteers; not pregnant; non smokers; not infants; no history of allergies to local anesthetics; without chronic use of medications; with complete natural dentition and no reports of numbness in the face or oral cavity	Volunteers with chronic diseases; pregnant women; smoking; infants; with a history of allergy to the local anesthetic and changes in face and mouth sensitivity; volunteers who did not attend the second visit and who did not have the medical records completely filled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7x9gby	Effects of different intensities of Aerobic Training in women with Headache	Recruiting	Intervention	2017-12-11	<NULL>	<NULL>	1516	Effects of different intensities of Aerobic Training in women with Migraine or Tension-type Headache: Randomized and Controlled Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-28	Associação Cauaruense de Ensino Superior	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7x9gby	<NULL>	"Age between 20 and 30 years; 
Nulliparous and nulliparous; For the group with headache: women with clinical diagnosis of migraine or episodic tension-type headache, performed by a neurologist, through anamnesis and neurological examination, based on the diagnostic criteria of the
ICDH; Body Mass Index (BMI) &lt;30kg / m² (WORLD HEALTH ORGANIZATION, 2011); Will be included in the migraine group, women diagnosed with migraine with aura, without aura or both, probable migraine or migraine associated with tension-type headache; 
Women who do not present with severe heart disease, neurological diseases, disabling musculoskeletal diseases, cognitive problems or those with clinical conditions of instability that imply risk and / or inability to participate in the training program;"	"Chronic migraine or chronic tension-type headache; 
Women with low adherence to training (frequency less than 75% of sessions in a one-month period) will be excluded; 
pregnancy; Drug or alcohol abuse; 
Use of antipsychotic or antidepressant medications;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-3t7fcy	A clinical study to evaluate the safety and blood concentration of melatonin nasal suspension in healthy male research participants.	Not yet recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1517	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of melatonin nasal suspension, after a single dose in healthy male participants.	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-12-21	Cosmed Indústria de Cosméticos e Medicamentos S.A.	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-3t7fcy	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50 kg and BMI less than or equal to 30 kg / m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; be non-tolerant to the nasal spray test; history of upper or lower respiratory tract infection (1 month prior to study participation).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-25dm9p	Benefits of light and shock in the head more walking on a treadmill walking in improving stroke sequelae.	Not yet recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1518	Effects of the combination of photobiomodulation, transcranial direct current stimulation and treadmill training on functional mobility in stroke survivors: Protocol for a randomized, sham-controlled, double-blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-25dm9p	<NULL>	diagnosis of stroke six months to five years prior to study; Hemiparesis secondary to single unilateral event; Independent gait; Age 45 to 60 years; performance of the functional tests and Physical Fitness; incremental cardiopulmonary exercise test; consent to their participation in the study by signing the Informed Consent Form	Joint pain in lower limbs that impairs function;Obesity of sufficient severity to limit gait training; Cardiovascular condition or cognitive impairment that renders the tests impossible; History of seizures; History of head trauma; Previous head surgery; metal implants on the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7rjx3k	Determination of Glycemic Response after Ingestion of Industrialized Enteral Diets Usually Used in Clinical Practice	Recruitment completed	Intervention	2017-12-12	<NULL>	<NULL>	1519	Glycemic Index of Enteral Formulas and Effect on Glycemic Control of Hyperglycemic Patients Hospitalized in Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-23	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-7rjx3k	<NULL>	From 18 to 69 years of age; stable body weight; body mass index (BMI) between 18.5 and 24.9 kg / m2; normal glucose tolerance; without diabetes or pre-diabetes; no history of eating disorders; without gastrointestinal disturbances; no medications that affect glucose tolerance; without pregnancy; without breastfeeding; not intolerant or allergic to any of the foods	Volunteers using medications that could interfere with glycemia; which showed instability of body weight; any metabolic disease (diabetes mellitus; hypoglycemia; hypothyroidism)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8ssqsw	Conservative treatment in female urinary incontinence: physiotherapy and bladder retraining comparative study	Recruitment completed	Intervention	2017-12-14	<NULL>	<NULL>	1520	Conservative treatment in female urinary incontinence: biofeedback and vesical training  comparative study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	universidade federal do rio grande do sul	hospital materno infantil presidente vargas	https://ensaiosclinicos.gov.br/rg/RBR-8ssqsw	<NULL>	Women over 18 years-old with stress urinary incontinence in the absence of genital prolapse greater than 2	Cognitive impairment; pregnancy or postpartum period until 6 months after birth; women on medications like antidepressants or diuretics of early start or changing dosage at the recruitment phase; other types of urinary incontinence; genital prolapse; urethral esfincter deficiency with leakage point below sixty centimeters of water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8p484w	Comparison between Internal Jugular Vein versus Axilar Vein for implantable ports	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1521	Internal Jugular vein versus Axilar Vein with single-incision for Implantable Ports: a prospective and randomized study	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-04-17	AC Camargo Cancer Center	AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-8p484w	<NULL>	Minimum age 18; cancer patients; only catheter for chemotherapy; ECOG (performance status) from 0 to 2; signed informed consent form.	Non compliance; anticoagulant therapy; coagulopathy (platelet count below 50,000 and/or protrombin time above 18s); death within 30 days after the procedure; another catheter in superior vena cava; previous long term catheter in superior vena cava; obesity (IBM&gt;40 Kg/m2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-84gg5w	Effects of Pilates Method Breaths on Balance, leg Tiredness, and Routine Activities of Fallers Elderly	Not yet recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1522	Effects of Pilates Method Breaths on balance, lower limb fatigue and functional capacity of fallers elderly: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-20	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-84gg5w	<NULL>	Age greater than or equal to 65 years; Good cognitive status, score greater or equal 17 in the mini-questionnaire questionnaire of mental state; History of falls in the last 12 months; Fear of falling measured by the FES-I-Brazil questionnaire.	Arthroplasty, arthrodesis, or knee, ankle and or hip osteotomy; Those who refuse to participate in data collection; Inability to perform the proposed monopodal balance test and or protocol of intervention; Less than 80% of frequency in sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-243w6r	Rehabilitation of the Patients with Low Back Pain	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1523	Low-Level Laser Therapy and Manual Therapy in the Treatment in Patients with Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-15	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-243w6r	<NULL>	Symptomatic volunteers with complaints in the lower back, more than 3 months of complaints	Patients with rheumatic; polytraumatic; cognitive deficits; central or peripheral nervous system lesions; patients with fracture sequelae in the lower limbs; fractures in lumbar spine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7zbxq5	A physiotherapy protocol based on the preferences of the individual with Parkinson disease for the health empowerment	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1524	Efects of physiotherapy with aproach based on patient preferences and conventional physiotherapy in motor and non-motor symptoms of individuals with Parkinson disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Estado de Santa Catarina	University of Miami Miller School of Medicine	https://ensaiosclinicos.gov.br/rg/RBR-7zbxq5	<NULL>	Diagnosis of Parkinson&apos;s disease; stages I through IV according to the Scale of HOEHN and YAHR; individuals correctly performing the drug treatment.	Individuals unable to practice physical exercises; Serious cognitive alterations; contraindication to any of the outcome tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-9gxbg6	Application of Different Medications to prevent the Sensitivity of Tooth Whitening	Recruitment completed	Intervention	2017-12-14	<NULL>	<NULL>	1525	The Effect of Different Medications in preventing the Sensitivity caused by Tooth whitening	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9gxbg6	<NULL>	Patients with good general health will be included in this study; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper central incisors with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who have undergone previous bleaching procedures will be excluded; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6f4x7p	Evaluation of the effects of medication for the control of chronic Hepatitis B and its effects on bone health	Recruitment completed	Observational	2017-12-14	<NULL>	<NULL>	1526	Assessment of Tenofovir effects on bone mineral density in chronic Hepatitis B patients non infected with HIV	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6f4x7p	<NULL>	Have a confirmed diagnosis of chronic hepatitis B; age greater than 18 years; being on Tenofovir for at least 12 months for group 1; being in use of Entecavir or Lamivudine for at least 12 months for group 2; have not made prior use of nucleoside / nucleotide analogues for group 3	Use of calcium and vitamin D supplements in the last month of inclusion in the study, as well as during the course of the study; liver cirrhosis score CHILD B or C; use of medications to treat osteoporosis; participants with previous thyroidectomy history; presence of chronic renal failure; concomitant HIV infection; concomitant hepatitis C virus infection; use of corticosteroids at doses greater than or equal to 1mg / kg body weight for more than 14 days of inclusion in the study, as well as during the course of the study; rheumatologic disease in activity; menopausal women or with secondary amenorrhea; women taking hormone replacement therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8dp876	Effects of Omega 3 and Cardo Mariano on MiRNAs related to non-alcoholic fatty liver disease.	Not yet recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1527	Epigenetic modulation by N-3 Polyunsaturated Fatty Acids and bioactive compounds (Silybum Marianum L) in Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8dp876	<NULL>	Be 19 years of age or older; diagnosis of NAFLD by abdominal ultrasonography, and liver biopsy in the last 24 months preceding the intervention	Viral hepatitis; infectious fever or outbreaks; cancer with or without chemotherapy and radiotherapy; inflammatory diseases of the gastrointestinal tract; transplant, trauma, surgery or hospitalization in the last 30 days; use of steroids or non-steroidal anti-inflammatories or immunomodulatory agents or antibiotics; use of n-3 fatty acid supplement in the last 3 months prior to study; pregnancy and lactation; alcohol intake greater than 20g / day for women and 30g / day for men	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-79z2sh	Formulation effect in patients with Alopecia Areata	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1528	Pilot study of the application of formulation containing Clobetasol Propionate Nanoparticles for the treatment of Alopecia Areata	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital Regional da Asa Norte - HRAN	Laboratory of Food, Drug and Cosmetics (LTMAC)	https://ensaiosclinicos.gov.br/rg/RBR-79z2sh	<NULL>	Male or female patients; aged between 18 and 65 years; confirmed clinical diagnosis of alopecia areata; Not responding to previous treatments for alopecia; Not being treated for alopecia for at least 6 months; Female pattern of alopecia with Ludwig grade II or higher; Absence of telogen effluvium in the last 6 months; Not allergic to any compound of the formulations	Hyper or hypothyroidism diagnosed during the study or decompensated; FAN greater than or equal to 1:320; Serum ferritin less than 40 ng/mL; Contraindications to the use of clobetasol propionate; Pre-treatment (within 6 months) with any of the active substances: Minoxidil hydrochloride and Finasteride.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-784f3y	Use of Vitamin E Cream for Prevention of Skin Lesions in Women with Breast Cancer who undergo radiotherapy	Recruiting	Intervention	2017-12-18	<NULL>	<NULL>	1529	Topical Application of Nanoparticles containing Vitamin E for Prevention of Radiodermatitis in Women with Breast Cancer: Randomized Clinical Trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-09-11	Escola de Enfermagem da Universidade de São Paulo	Santa Casa de Misericórdia de Passos	https://ensaiosclinicos.gov.br/rg/RBR-784f3y	<NULL>	be 18 years or older; and present the entire skin on the day radiotherapy begins.	previous radiotherapy in the same area; previus radical mastectomy; be pregnant; have a malignant fungating wound in the irradiated area; report history of adverse reaction to components of the cream formula; be on concomitant chemotherapy; use concomitant topical or systemic anti-inflammatory therapy; collagen diseases such as systemic lupus erythematosus and scleroderma; receive another type of intervention to prevent radiodermatitis, not included in the standard or experimental protocol; and refuse to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8nr8xy	Efficacy mouthwash developed with vegetable oils	Recruitment completed	Intervention	2017-12-18	<NULL>	<NULL>	1530	Clinical study of the efficacy of oral rinse-containing vegetable oils for the control of dental biofilm	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2016-10-04	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-8nr8xy	<NULL>	Be between 18 and 30 years old; both sexes; presence of at least 70% of teeth in the arches; absence of oral pathologies not related to the dental biofilm; present at least 40% of biofilm in the dental faces evidenced in the initial examination.	Smoking; pregnants; recent or current use of antibiotics and medicines that alter salivary flow; being on radiotherapy or chemotherapy; present systemic diseases that generate oral manifestations; presence of periodontal disease or active carious lesions; presence of dental calculus; make use of orthodontic appliance or occlusal plates; do not accept to signing the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6y979g	Laser therapy in Patients with Rapids Maxillary Expansion needs	Not yet recruiting	Intervention	2017-12-19	<NULL>	<NULL>	1531	Low-level Laser therapy in Rapid Maxillary Expansion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6y979g	<NULL>	Patients in the mixed dentition phase; maxillary atresia	Patients with previous orthodontic treatment history; that require other modalities of interceptive orthodontic treatment within the experimental period (10 months); systemic diseases that interfere with bone metabolism, or use medications that alter bone metabolism; craniofacial malformations; suspected or diagnosed oral cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8zjf6b	E-BRAIN Project: Investigating the effect of different forms of physical exercises on the cognition of the elderly	Recruitment completed	Intervention	2017-12-20	<NULL>	<NULL>	1532	Physical exercise, cognition and neuroplasticity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade de São Paulo - Escola de educação Física e esporte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8zjf6b	<NULL>	"Present score in the mini-mental state exam (Mini Metal) greater than 23 points

They should not have performed any type of physical exercise intervention in the six months prior to the start of the present clinical trial;
Being literate and not having a higher education (between 3 and 12 years of schooling - elementary school to high school);
No motor impairment, musculoskeletal injury or comorbidities that prevent exercise;
Have no history of stroke or neological disease;
Have a medical certificate attested by the professional involved in the research, confirming the possibility of participating in the exercise progra"	"Do not agree to participate in the evaluations foreseen in the research;
Not available to participate in interventions that will occur on weekdays, in the afternoon or at night."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6m8zhy	Clinical cohort of children with microcephaly associated with Congenital Zika Infection in Pernambuco	Recruiting	Observational	2017-12-14	<NULL>	<NULL>	1533	Clinical cohort of children with microcephaly and other abnormalities associated with congenital zika infection in Pernambuco	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-10-10	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6m8zhy	<NULL>	Pregnant women with cutaneus rash and children with microcephaly and oothers children com microcefalia and others clinical conditions related to Zika Virus	Pregnant women with rash caused by others provd  Arboviroses infection  or infection  by TORCHS group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-59k78k	Comparison between the effects of Roux-en-Y gastric bypass (traditional surgery) and mini-gastric bypass (new technique) as treatments of morbid obesity	Recruitment completed	Intervention	2017-12-20	<NULL>	<NULL>	1534	Comparison between the effects of Roux-en-Y gastric bypass and one-anastomosis gastric bypass as treatments of morbid obesity: prospective randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-59k78k	<NULL>	Morbidly obese individuals which are candidates for bariatric surgery according to the National Institutes of Health (NIH) and Brazilian Dept. of Health criteria; any gender; obese for at least 5 years; aged 18-70 years old; Body mass index &gt;= 40 kg/m2; body mass index &gt;= 35 kg/m2 with obesity-related co-morbidities (hypertension, dyslipidemia(s), diabetes mellitus, glucose intolerance, degenerative ostheoarthropathies and/or sleep apnea).	Loss to follow-up before completion of one-year follow-up; vulnerable groups; non-compensated psychiatric disorders; use of alcohol or illicit drugs; misunderstanding of the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8k5jsj	Evaluation of the influence of metabolic and genetic factors on energy regulation in stomach reduction surgery	Data analysis completed	Observational	2017-12-21	<NULL>	<NULL>	1535	Assessment of the influence of metabolic and genetic factors on energy homeostasis after Bariatric Surgery	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-05	Instituto de Biociências de Botucatu - UNESP	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-8k5jsj	<NULL>	Being female; Age between 20 and 45 years in menacme; Body Mass Index greater than 40 kg / m2 and less than 60 kg / m2; Waiting in the queue to perform the surgical procedure; Do not present diseases that cause changes in energy metabolism such as diabetes mellitus, hypothyroidism, HIV infection, neoplasms, heart diseases, nephropathies and liver diseases; Do not present diseases that cause edema such as venous insufficiency, pregnancy, thrombosis, sepsis, inflammation, lymphedema; Do not use medicines that cause metabolic and absorptive changes such as diuretics, amphetamines, thyroid hormones, topiramate, orlistat, corticosteroids, etc.	We excluded women who did not present optimal health conditions for the surgical procedure (diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies) after conducting the admission tests for the research and patients living outside the DRS-10 region (near the collection site).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7xzcqp	Perceived Exertion as a way to Differentiate the Functional Capacity in Older Adults	Recruitment completed	Intervention	2017-12-21	<NULL>	<NULL>	1536	Physical Training to Differentiate the Functional Capacity of Older Adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-06	Faculdade Inspirar	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7xzcqp	<NULL>	age&gt; 60 years; be dependent on at least one or more activities of daily living on the Katz index or the Lawton questionnaire; be able to perform the functional tests with autonomy, or the use of a walking stick	older adults who use orthoses, making it impossible to perform any tests; older adults who have a severe cognitive impairment who can not understand the instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-4hz5vn	Impact of Pelvic Exercise guidance on Urinary loss and pelvic Organ Falls	Not yet recruiting	Intervention	2017-12-21	<NULL>	<NULL>	1537	Impact of guidance of Pelvic Exercises on urinary Incontinence and genital Prolapse	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4hz5vn	<NULL>	Women with urinary incontinence with predominance of stress urinary incontinence; Women who voluntarily accept and sign the Informed Consent Form (TCLE); Women who have a cell phone; Know how to read and write.	Neurological problems that compromise the understanding for the practice of exercises, or suggestive of neurogenic bladder; Diabetes Mellitus; Total absence of muscle contraction of the pelvic floor (P = 0); pelvic floor hypertonicity; Anterior surgery of the pelvic floor; Prolapse of pelvic organs greater than stage II; Use of local hormone; Proven or suspected pregnancy; Prior treatment for urinary incontinence; Three or more lower urinary tract infections in the last 12 months; Ultrasound image with poor resolution for analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-2nnywk	Influence of Aerobic Exercise on cognitive function in Depressed elderly	Recruitment completed	Intervention	2017-12-21	<NULL>	<NULL>	1538	Effect of Aerobic Training on cognitive function and symptomatology of Depression in the elderly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Programa de Pós-Graduação em Educação Física da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2nnywk	<NULL>	Elderly persons previously diagnosed by physicians qualified both in the public and private network of Recife, PE, Brazil; who are 60 years of age or over; have not exercised for at least six months; sign the informed consent form.	To have acute musculoskeletal pain, interfering in the performance of the tests and in the training; history and sequelae of neurodegenerative diseases; express the desire to stop participating in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-69fnqt	Use of Acupuncture in the treatment of Dry Mouth and Oral Wounds caused by treatment in patients with head and neck Cancer	Data analysis completed	Intervention	2017-12-21	<NULL>	<NULL>	1539	Use of Low-power Laser Therapy and Acupuncture in the treatment of radio-induced Mucositis and Radiodermatitis in patients with head and neck Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Estadual de Montes Claros	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-69fnqt	<NULL>	Histopathological diagnosis confirmed squamous cell carcinoma of the head and neck; Age over 20 years of age; In need of radiotherapy treatment; both sexes; Agree to participate in the study	Individuals who do not have capacity or have limitations that prevent them from responding to the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:00
RBR-2zgdgj	Use of transcutaneous electrical nerve stimulation (TENS) to relieve labor pain	Recruitment completed	Intervention	2017-12-26	<NULL>	<NULL>	1540	Randomized study of the use of transcutaneous nervous eletric stimulation (TENS) in the relief of pain in labor	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-26	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-2zgdgj	<NULL>	Parturients with single gestation; cephalic presentation; preserved fetal vitality; with gestational age greater than or equal to 37 weeks; presenting cervical dilation greater than or equal to 4 cm and less than or equal to 7 cm.	indication of cesarean section prior to labor; presence of fetal death or fetal malformation; parturients with severe pathologies (clinical and obstetrical); twin pregnancy; rupture of the ovary membrane; and the use of any pharmacological method were excluded. pain control; presence of dermatitis or any infection at the site of TENS electrodes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-2jcc8d	Impact of Pilates mat Compared to Walking on Fat-Treated Rolling Stones and Insulin Resistance	Recruiting	Intervention	2015-05-25	<NULL>	<NULL>	1541	Impact of Pilates mat versus aerobic exercise on hepatic steatosis and insulin resistance in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-05	Hospital Universitário- Prof Edgard Santos- UFBA- HUPES	Hospital Universitário- Prof Edgard Santos- UFBA- HUPES	https://ensaiosclinicos.gov.br/rg/RBR-2jcc8d	<NULL>	Female volunteers; aged between 30 and 70 years; abdominal obesity; hepatic steatosis confirmed by ultrasonography	Volun smokers; alcoholic; decompensated heart disease; decompensated liver disease; physically active	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-9fjfnh	Curcuma longa (Tumeric) as an auxiliary treatment for Idiopathic Childhood Nephrotic Syndrome	Recruiting	Intervention	2018-01-02	<NULL>	<NULL>	1542	Curcuma longa as adjuvant in the treatment of Idiopathic Childhood Nephrotic Syndrome	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fjfnh	<NULL>	The study will include all patients older than one year; who have the diagnosis of idiopathic childhood nephrotic syndrome; who are followed up at the Childhood Nephrology Clinic of the Clinics Hospital of Ribeirão Preto of the University of São Paulo,  (i.e. ANEI); and whose parents or legal guardians authorize participation through signature of informed consent.	Will not be included in the project those patients younger than one year; those with nephritic syndrome characteristics; with another etiology for the nephrotic syndrome, as secondary causes (e.g. IgA nephropathy, membranoproliferative glomerulonephritis, systemic lupus erythematosus and secondary to Infectious diseases); or whose parents or legal guardians disagree with their participation in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-6kyh2g	Treatment of Temporomandibular Dysfunction with the use of fatigue-resistance Exercises	Not yet recruiting	Intervention	2018-01-03	<NULL>	<NULL>	1543	"Isometric Exercises of Muscular Resistance to Fatigue in the treatment of Dysfunction
Temporomandibular via Biofeedback: randomized control study"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6kyh2g	<NULL>	Volunteers who have temporomandibular pain lasting more than 06 months; Who have a permanent dentition with at least 28 permanent teeth; Without periodontitis.	Volunteers who already suffer craniofacial trauma; Rheumatic diseases; Volunteers who use analgesics; Anti-inflammatory; Neurological or cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-5np3p6	Transcutaneous diaphragmatic stimulation in the spinal cord injury: a retrospective analysis of the time ventilador withdrawal  2007 to 2016	Recruitment completed	Observational	2018-01-03	<NULL>	<NULL>	1544	Transcutaneous electrical diaphragmatic stimulation in the spinal cord injury: an weaning retrospective analysis 2007 to 2016	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Hospital de clinicas da universidade estadual de Campinas	Hospital de clinicas da universidade estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5np3p6	<NULL>	"cervical spinal cord injury
Submitted to tracheostomy
difficult weaning from mechanical ventilation
48 complete hours of nebulization"	"thoracic or lumbar spinal cord injury
48 not complete hours of nebulization
not Submitted to tracheostomy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4hsyy4	Comparison between Pethidine and Dipyrone as Analgesics during Labor	Data analysis completed	Intervention	2018-01-04	<NULL>	<NULL>	1545	Labor Analgesia: Comparison between low doses of Pethidine and Sodium Dipyrone	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-05-28	UNIFOR - Universidade de Fortaleza	Secretaria municipal de saúde de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4hsyy4	<NULL>	Presence of at least 3 uterine contractions lasting 40 seconds or more every 10 minutes; Patients presenting a dilation of the uterine cervix equal to or greater than 5 cm; Measurement of pain through the use of visual analogue scale equal to or greater than 8; Gestational age of 37 up to 40 weeks and 6 days; Fetuses in cephalic presentation	Parturients with any of the following events: poorly controlled arterial hypertension, diabetes, restricted intrauterine growth and placental abruption; Use of oxitocyn by pregnant women in the period from the begining of labor until 2 hours after administration of the analgesic; Hypothyroidism diagnosed previously and without therapy; Patients taking monoamine oxidase inhibitors; Occurrence of labor less than 1 hour after analgesia; Parturients with body mass greater than 100 kg; Indication of cesarean delivery during admission; Addison&apos;s disease previously diagnosed; BCF&apos;s &lt; 110 bpm, during admission; BCF&apos;s &gt; 160 bpm, during admission; Patients allergic to sodium dipyrone; Patients allergic to pethidine; Users of chlorpromazine; Phenobarbital users; Phenytoin users; Fetus without vilality; Twin pregnancy; Drug addiction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-95scpc	Nutritional status and level of inflammation of patients with inflammatory bowel disease in saffron use in outpatient care	Recruiting	Intervention	2018-01-05	<NULL>	<NULL>	1546	Nutritional status and inflammatory profile of patients with Ulcerative Colitis in use of turmeric in outpatient care	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-09-08	Hospital das Clínicas Universidade Federal de Goiás - GO	Instituto Goiano de Gastroenterologia Ltda	https://ensaiosclinicos.gov.br/rg/RBR-95scpc	<NULL>	patients clinically diagnosed with ulcerative colitis ; changes in the examination of fecal calprotectin ; age greater than 18 years; outpatient care ; both sexes ; Clinically stable ; noninstitutionalized ; have performed biopsy and sigmoidoscopy to confirm the diagnosis ; accept participate.	allergy saffron ; heart disease ; liver disease ; leukopenia ; thrombocytopenia ; pancreatitis ; gallstones ; kidney disease; decompensated diabetes ; pneumonia; sepsis or infection ; pregnant women ; nursing mothers ; patients with difficulty swallowing .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-5zbgpp	Acupuncture as Treatment of Cervical Wound and Avaliation of Regeneration Process Factors	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1547	Treatment of Cervical Gladular Epithelium Ectopy with Sistemic Acupuncture and Analisys of Interference Factors in the Metaplasic Process	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zbgpp	<NULL>	women in the menamma with ectopy of the cervical glandular epithelium on the cervical surface in the vaginal environment without any previous treatment	non-pregnant, non-lactating, nonimmunosuppressed of any kind	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-2bzdm3	Cow milk with higher concentration of Selenium and Vitamin E improves children&apos;s health	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1548	Effects of the inclusion of Sunflower Oil with addition of Selenium and Vitamin E in the diet of lactating cows on the production and milk composition and its influence on human nutrition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Faculdade de Zootecnia e Engenharia de Alimentos	Agência Paulista de Tecnologia dos Agronegócios	https://ensaiosclinicos.gov.br/rg/RBR-2bzdm3	<NULL>	healthy volunteers; both genders; age between 8 and 10 years; did not use compulsory medication	volunteers aged less than 8 years and over 10 years; volunteers who stayed 2 consecutive days without receiving milk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-4xbqbw	Professional Exhaustion and Alternative Practices in Primary Care Nurses	Recruitment completed	Intervention	2018-01-05	<NULL>	<NULL>	1549	"Burnout Syndrome and Integrative and Complementary Practices
in Health in Nurses of Primary Health Care"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	Programa de Pós-Graduação em Enfermagem na Atenção à Saúde da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4xbqbw	<NULL>	Nurses with a minimum of one year of professional work in the same health unit of Primary Care; nurses without a double professional relationship; nurses diagnosed with Burnout Syndrome	Nurses with limitations that make it impossible to receive auriculotherapy intervention; nurses on medical leave or vacations; nurses doing some kind of stress-specific treatment, pregnant women with coagulation disorders or developing malignant neoclassical diseases; nurses using beta-blockers or neuroleptic drugs or with ear injury.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-5hm62q	Effects of Unripe Banana Flour on blood tests and anthropometric data on Overweight and Visceral Fat subjects	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1550	Evaluation of the effects of regular consumption of Unripe Banana Flour on the metabolic and anthropometric parameters of Overweight Individuals and Visceral Adiposity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5hm62q	<NULL>	Women between the ages of 20 and 50; Body mass index greater than or equal to 25 kg / m² and less than 40 kg / m²; Waist circumference greater than or equal to 80 cm; Not having participated in a weight loss program in the last six months; Be healthy.	Cigarette smoker volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; being pregnant or nursing; practice restrictive diets; allergic reactions to any of the components of the shake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-27fmyt	Effects of nutritional counseling and / or supplementation with Whey Protein on the nutritional status and metabolism of individuals with risk factors for Cardiovascular Diseases	Recruiting	Intervention	2018-01-05	<NULL>	<NULL>	1551	Effects of nutritional orientation and or supplementation with Whey Protein on the nutritional and metabolic status of individuals with risk factors for Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-27fmyt	<NULL>	Inclusion criteria were established for the participation of the research: adult women, aged between 20 and 59 years and BMI between 25 and 40 kg / m2.	Adult women diagnosed with renal, cardiovascular, hepatic, cancer, pregnant or lactating diseases will be excluded from the study, following a specific diet; Chronic alcoholics; On the use of anti-inflammatory medications or medicines that affect appetite or body weight; In inflammatory or infectious process on the day of collection; Who have participated in any food restriction program, in the use of food supplements in the last six months and lactose intolerant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-36zcfg	The Effects of Auriculotherapy in Women With Breast Cancer During Chemotherapy Treatment	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1552	The effects of auriculotherapy in women with breast cancer undergoing chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Hospital de Clinicas da Universidade Federal do Paraná	Hospital de Clinicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-36zcfg	<NULL>	Women; Diagnosis of breast cancer; Chemotherapy treatment; Age between 18 and 99 years	Using anxiolytics; Antidepressants; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-3kxkzn	Effect of training in vibrating plataform in subjects with Chronic Obstructive Pulmonary Disease	Data analysis completed	Intervention	2015-08-28	<NULL>	<NULL>	1553	Effect of whole-body vibration training in subjects with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3kxkzn	<NULL>	75 subjects of both genders; with stable COPD; age between 45 and 80 years; women after menopause.	Acute or chronic associated disease not stable; included in  some form of physical training; use of antiinflammatory and immunosuppressive medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-5zynmc	Physical activity in adolescents with cardiovascular risk	Recruitment completed	Intervention	2018-01-08	<NULL>	<NULL>	1554	Influence of a physical activity program in adolescents with cardiovascular risk	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5zynmc	<NULL>	Students of both sexes; aged between 10 and 16 years; enrolled in the year 2016 in elementary and secondary education of the public network of the city of Montes Claros.	Students who do not bring the free and informed consent form signed by parents and / or guardians; Who are pregnant or with conditions that prevent the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-23nyf4	Comparison of the effects of Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1555	Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease: A Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-23nyf4	<NULL>	"Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease according to Ordinance No. 228/2010 of the Ministry of Health of Brazil;
Both sexes;
Patients aged 18-80 years;
Stage 1 to 3 of Hoehn and Yahr&apos;s original scale."	Other neurological diseases; orthopedic, rheumatic and / or vascular pathology, with moderate or severe functional restriction in one or both lower limbs; uncontrolled hypertension and / or cardiac or respiratory disease that limits the execution of the protocol; with lowering of the cognitive level; with medical restriction to perform exercises; unable to perform the motor imagination, in physical therapy or occupational therapy for 3 months or more; with moderate to severe depression; with visual and auditory deficits that do not guarantee a good participation in the protocol; after deep brain stimulation surgery; with vestibular alterations; with lack of sensitivity in the lower limbs; users of orthosis for lower limbs; User of prosthetics; with edemas in the lower limbs and amputees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-3jy7kg	Effects of Constraint Induced Moviment Therapy associated with Elastic Bandage in the upper-extremity of patients with loss of acute or chronic motion	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1556	Effects of Constraint Induced Moviment Therapy associated with Funcional Bandage in the upper-extremity of acute and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3jy7kg	<NULL>	Hemiparetic individuals in upper limb; both genders; 5 to 60 years; Signature of the Informed Consent Form (TCLE); diagnosis of neurological injury; minimum motor criterion for the execution of the TCI; without cognitive deficit.	Allergy to Functional Bandage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-73c7bz	Pilates in posture and body awareness in the blind.	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1557	Postural analysis and body awareness in visually impaired individuals after intervention with the pilates method	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Faculdade Santo Agostinho	Faculdade Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-73c7bz	<NULL>	Be between 20 and 50 years old, of both sexes, be blind, be frequent attenders of the Association of blind people of the State of Piauí, have a good cognitive understanding.	Acute fracture, spinal cord tumor, acute infections, malignant spinal neoplasm, frank disc heation with signs of progressive neurological deficit, neoplasms of muscle tissue or other soft tissues, generalized congenital hypermobility, syringomyelia, etiology hydrocephalus unknown, labyrinthitis, autism, osteoporosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-397qws	Effect of Transcutaneous Electric Nerve Stimulation (TENS) in delayed onset muscle soreness (DOMS): prevention and treatment	Data analysis completed	Intervention	2018-01-08	<NULL>	<NULL>	1558	Effect of TENS in Delayed Onset Muscle Soreness (DOMS): prevention and treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-397qws	<NULL>	Healthy; physically inactive volunteers; both sexes; aged 18 to 40 years.	Previous experience with the use of TENS; muscoloskeletal disorders; heart diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-64vys2	Comparison of Exercises for Urinary Incontinence with and without Electrical Stimulation	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1559	Comparison of a Kinesiotherapy Protocol with and without Association of Posterior Tibial Nerve Stimulation for Mixed Urinary Incontinence: A Randomized and Blind Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-64vys2	<NULL>	To present urinary incontinence; Have not performed any previous physiotherapeutic treatment for pelvic dysfunctions; Do not have pacemakers or cardiovascular disease; Do not be pregnant.	volunteers with infectious disease; volunteers with prolapse grade III or IV; complaint of unbearable pain upon physical examination of muscle strength; more than 3 absences during the treatment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-7543ns	Auricular acupuncture for post-operative nausea and vomiting.	Recruiting	Intervention	2018-01-09	<NULL>	<NULL>	1560	Influence of Auricular Acupuncture in order to prevent nausea and vomiting after Laparoscopic Cholecystectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Faculda de Ciências Médicas Universidade de Pernambuco	Faculda de Ciências Médicas Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7543ns	<NULL>	adult females between; 18 and 70 years old; with Body Mass Index under 35; who belong to classification 1 and 2 of the American Society of Anaesthesiology; submitted to uncomplicated Laparoscopic cholecystectomy.	Laparoscopic cholecystectomy with surgical or anesthetic complications; operation time longer than 90 minutes; nausea and vomiting on the immediate preoperative time; patient ASA 3 or more; use of antiemetic 12 hours before the procedure; continuous use of analgesic or corticoids; abusive history of alcohol and drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-972497	Evaluation of drug adhesion and foot care of Diabetic patients under pharmacist orientation	Recruitment completed	Intervention	2018-01-10	<NULL>	<NULL>	1561	Evaluation of Pharmacological Adhesion and Self Care at the feet of diabetic patients submitted to Pharmaceutical intervention.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-972497	<NULL>	Users with the diagnosis of type 2 diabetes mellitus; in use hypoglycemic agents; both genders; age greater than 40 years; who are registered in the position studying for at least 6 months.	Diabetes mellitus type 1; gestational diabetes mellitus; patients in dialysis treatments; individuals residing in the open area.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-2f3fvr	Effects of Aquatic Exercises on the heart in Overweight adults	Recruiting	Intervention	2018-01-11	<NULL>	<NULL>	1562	Effects of Deep Water Running on the cardiac autonomic control and functional capacity in adults with Overweight and Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2f3fvr	<NULL>	Participants of both genders; adults ranging from 39 to 59 years of age; with overweight or obesity I.	Volunteers with cardiorespiratory, musculoskeletal or neuromuscular diseases that impede the performance of the aquatic training program; hydrophobia; skin wounds; and infectious-contagious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-3x8xc3	Assessment of Mastication and Quality of Life in Frail Elderly Persons	Recruitment completed	Observational	2018-01-11	<NULL>	<NULL>	1563	Masticatory Function and Quality of Life in Frail Elderly Persons	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-13	Faculdade de Odontologia de Piracicaba - UNICAMP	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-3x8xc3	<NULL>	Completely edentulous; wearing bimaxillary dentures; presence of the frailty phenotype (experimental group); abscence of cognitive problems and / or dementia; abscence of neurodegenerative diseases such as Parkinson&apos;s and Alzheimer&apos;s.	History of stroke; signs and symptoms of temporomandibular disorders; cognitive deficit; uncontrolled systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-35ygdr	Relation of Anemia in pregnant women, oral Infection and Low birth weight	Recruiting	Observational	2018-01-11	<NULL>	<NULL>	1564	The influence of Maternal anemia mediated Periodontitis on Low birth weight	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-01-01	Universidade Estadual de Feira de Santana	Universidade Federal do Recôncavo da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-35ygdr	<NULL>	Pregnancy. Fetal gestational ages between 8 and 32 weeks. Assistance from the public health system. Live births, full-term births.	Women if they had a twin pregnancy. Cases of miscarriage of less than eight weeks. History of bleeding that required hospital treatment for at least 24 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-4c6s7s	Epsilon aminocaproic acid and Tranexamic acid in Knee prosthesis	Recruiting	Intervention	2018-01-12	<NULL>	<NULL>	1565	Epsilon Aminocaproic Acid(EACA) and Tranexamic Acid(TXA) in Total Knee Arthroplasty	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Associação Evangelica Beneficiente de Londrina	Associação Evangelica Beneficiente de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4c6s7s	<NULL>	Patients clarified about the research and with knee tricompartmental osteoarthrosis of both sexes; with indication of total knee prosthesis; No diagnosis of inflammatory disease; no history of atrial fibrillation; deep vein thrombosis; previous pulmonary embolism	Use of anticoagulant medications up to seven days before surgery. Anterior surgeries in the same knee with cicatricial alterations that make it impossible to close the joint capsule. Patients who during the operative act require the release of soft parts that are more extensive than the programmed ones that make it impossible to properly close the joint capsule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-5hhnmx	The evolution of psychiatric care in municipality of Sorocaba in São Paulo - Brazil: from a hospital-based model to full deinstitutionalization	Data analysis completed	Observational	2018-01-12	<NULL>	<NULL>	1566	Matrix support in mental Health in primary care: strategy for resolving and satisfying the team	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Fundação São Paulo - Campus Sorocaba da Pontifícia Universidade Católica de São Paulo	Pontificia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5hhnmx	<NULL>	Health Care Professionals. Both genders. Between 18 and 70 years.	Workers in other áreas. Both genders. Between 18 and 70 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-6gdktv	Effects of PEEP-ZEEP technique on pulmonary secretion removal and respiratory system.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1567	Effects of PEEP-ZEEP Maneuver on pulmonary secretion clearance and respiratory mechanics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-09	Universidade Federal do Triângulo Mineiro	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gdktv	<NULL>	Patients with pulmonary secretion on mechanical invasive ventilation; hemodynamically stable (MBP higher than 65 mmHg); PEEP lower or equal than 10 cmH2O; oxygen inspiratory fraction lower or equal than 0,4; peripheral oxygen saturation higher than 90%.	Intracranial hypertension; cor pulmonale; pulmonary hypertension; pregnancy; pneumothorax not drained; bronchospasm; rib fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-2mf595	Serious Game for evaluation and treatment in Stroke	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1568	Evaluation and rehabilitation using a Serious Game in hemiparetic patients for Stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universida do Estado de Santa Catarina (UDESC)	Associação Catarinense de Ensino (ACE) / Faculdade Guilherme Guimbala (FGG)	https://ensaiosclinicos.gov.br/rg/RBR-2mf595	<NULL>	"Stroke hemiparetic patients, clinically stable and in the subacute or chronic phase of the disease;
Age range equal to or greater than years;
Agree and show interest in participating in the project from start to finish."	"Patients who present hemiparesis due to other pathologies, other than stroke, as well as hemiplegic patients;
Patients who present bilateral motor impairment, which impedes characterization as hemiparetic;
Patients with severe visual and / or auditory impairment;
Uncooperative and / or severely cognitively impaired patients;
Patients who can not independently stand up (use of aid devices: crutch, cane or walker);
Patients who are performing any type of rehabilitation for the trunk and lower limbs (hydrotherapy, conventional physiotherapy, physical exercises in general)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3vcqt9	A comparative study between two surgeries for women with Stress Urinary Leakage: Minisling (Solyx) and Transobturator Sling (Obtryx II)	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1569	Randomized controlled trial between Minisling (Solyx) vs Transobturator Sling (Obtryx II) in women with Stress Urinary Incontinence (SUI)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Hospital da Mulher José Aristodemo Pinotti	Boston Scientific	https://ensaiosclinicos.gov.br/rg/RBR-3vcqt9	<NULL>	"Women with 18 years and/or older.
Positive cough stress test for SUI or positive findings of stress urinary incontinence at urodynamic study (UDS).
Post-voiding residue &lt; 100 ml or less 20% of total urinary volume
Maximum bladder capacity over 300 ml"	"Women with overactive bladder or recurrent UTI or previous urogynecological surgeries.
Previous pelvic radiotherapy. 
Presence of pelvic organ prolapse (POP) stage 2 and over.
Past or recent history of bladder lithiasis, inferior urinary fistula or diverticulum. 
Current use of anticoagulants.
Previous surgical history of foreign-body reaction like (eg. history of surgery with prosthetic complications)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9jk5xn	Effect of Caffeine Administration on Responses to Physical Exercise	Recruitment completed	Intervention	2018-01-15	<NULL>	<NULL>	1570	Effect of Mouthwash with Nutritional Products containing Caffeine on the Immunometabolic Profile and Physical Performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9jk5xn	<NULL>	"First stage: healthy adult men; healthy adult women; have been training triathlon for over a year; aerobic capacity greater than 60% of VO2max; have a fixed routine of intense and moderate exercise (ranging from 4-6 times per week with a duration of 60-240 min per training day).

Second stage: healthy adult males; CrossFit® practitioners for at least one year."	First and second steps: use of anabolic steroids; use of dietary supplements; use of immunosuppressive drugs; use of antibiotics; use of stereochemical and non-stereochemical anti-inflammatories; in a food restriction program; carriers of immune diseases; hepatic diseases; renal diseases; pneumopathy; cardiopathies; chronic alcoholics; smokers; injured individuals; individuals in the inflammatory process.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9tmm4d	Analysis of the mental and physical exhaustion and the relation with immune response of cancer patients submitted to exergames.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1571	Analysis of mental and physical fatigue and its relatonship with cytokines in cancer patients submitted to exergames practice. Randomized, controlled, follow-up and cross-over study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Universidade Federal de Alfenas	Fundação de apoio à pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9tmm4d	<NULL>	"Experimental group 1: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities.

Experimental group 2: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities."	Individuals without cancer diagnostic; cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergaming.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3x7gz8	Effects of Music Yherapy on the heart rhythm of mothers of infants hospitalized in Neonatal ICU	Recruitment completed	Intervention	2018-01-17	<NULL>	<NULL>	1572	&quot;Influence of the Music Therapy Intervention on the Cardiac Autonomic Modulation in mothers in the Neonatal ICU: Randomizaed Study&quot;	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Universidade Federal de Goiás	Hospital e Maternidade Dona Íris	https://ensaiosclinicos.gov.br/rg/RBR-3x7gz8	<NULL>	Mothers who are with their newborn baby hospitalized in the ICU of Dona Iris Hospital and Maternity; aged between eighteen and forty years.	"Cognitive impairment and / or hearing impairment that impedes understanding of the assessments and questionnaires involved;  Uncontrolled systemic diseases, such as diabetes mellitus, systemic arterial hypertension, and thyroid dysfunction reported by the participant; Electrocardiogram change;
use of beta-blocker medications reported by the participant; continued use of illicit drugs and / or alcohol reported by the participant; use of antidepressant informed by the participant; in psychotherapeutic care informed by the participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3knbwp	Effects of a therapeutic exercise program associated or not with electrical currents in patients with chronic neck pain	Not yet recruiting	Intervention	2018-01-17	<NULL>	<NULL>	1573	Effects of a program of therapeutic exercises associated or not to electrotherapy in patients with chronic neck pain: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3knbwp	<NULL>	Individuals of both genders; aged between 18 and 45 years; and with chronic cervicalgia (for more than 90 days).	Individuals who presented a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; pain radiated to the upper limbs; have undergone physiotherapeutic treatment for the cervical region in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-2z7mtr	Inspiratory Muscle training in patients with traumatic brain injury undergoing prolonged mechanical ventilation: Randomized controlled trial study	Recruiting	Intervention	2018-01-17	<NULL>	<NULL>	1574	Inspiratory Muscle training in patients with traumatic brain injury undergoing prolonged mechanical ventilation: Randomized controlled trial study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Hospital de Base do Distrito Federal	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2z7mtr	<NULL>	adults (aged from 18 to 60 years); traumatic brain injury individuals with mechanical ventilation stay at least 72 hours	previously diagnosed neuromuscular diseases;  intracranial hypertension; pregnancy; platelets &lt; 40.000; hemodynamics instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3wss27	Effects of Respiratory Muscle Training in Heart Disease and Sleep Apneia	Recruiting	Intervention	2018-01-18	<NULL>	<NULL>	1575	Effects of Inspiratory Muscle Training in patients with Chronic Heart Failure and Sleep Apneia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Ciências da Saúde da Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3wss27	<NULL>	Volunteers with left ventricular ejection fraction&gt; 50%; functional classification of I to III of the disease, according to the New York Heart Association (NYHA); both genders ; aged between 30 and 75 years;  non-smokers; non-alcoholic; without chronic obstructive pulmonary disease (FEV1 / FVC&gt; 70% and FEV1&gt; 70% predicted); diagnosed sleep apnea (central apnea / hypopnea index greater than or equal to 5 per hour).	Volunteers with unstable angina; myocardial infarction in the last six months; osteomioarticular, rheumatic and cognitive diseases; systemic arterial hypertension and uncontrolled diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-8mwkyq	A Experimental Study in Type 2 Diabetes Patients	Data analysis completed	Intervention	2018-01-18	<NULL>	<NULL>	1576	Effect of Aerobic Train in the Type 2 Diabetes Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-29	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8mwkyq	<NULL>	patients had to be voluntary; both gender; body mass index  igual or above 25 kg/m²; sedentary and diagnosed with T2DM	history of alcohol or drug abuse; diagnoses of cardiac pathologies; not being obese and sedentary; uncontrolled blood glucose spikes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-459x9d	Stimulation of the primary senses in the elderly with Dementia or Depression	Recruitment completed	Intervention	2018-01-18	<NULL>	<NULL>	1577	Multisensory Stimulation in the treatment of the elderly with Dementia or Depression	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Faculdade de Medicina de Ribeirão Preto	Programa de Pós Graduação Interunidades em Bioengenharia	https://ensaiosclinicos.gov.br/rg/RBR-459x9d	<NULL>	"Old people; over 65 years old; both gender; diagnosis of moderate or severe dementia, confirmed or not with depression as a secondary diagnosis; residents of a long-term institution.

Formal caregivers of the nursing home, that old people live."	Elderly with epilepsy; elderly with severe visual and hearing impairment not corrected by visual and auditory resources; elderly people with aphasia of expression and communication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-69g952	Non-pharmacological techniques for cognitive improvement in schizophrenia	Data analysis completed	Intervention	2018-01-18	<NULL>	<NULL>	1578	Investigation of the Effects of Neurostimulation Techniques in Schizophrenia and Their Impact on Executive Functioning	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-69g952	<NULL>	Subjects between 18 to 65 years old diagnosed with schizophrenia; No history of substance abuse/dependence, in exception to tobacco and/or caffeine;  No diagnosis of any neurological conditions (e.g. Parkinson’s disease); (d) No history of seizures;  No unexplained loss of consciousness; Stability of pharmacological treatment for at least 6 weeks; No contraindications to tDCS, such as metal in the head or implanted brain medical devices; No pregnancy at enrollment; acceptance to participate in the study and provide the written informed consent.	Subjects with psychiatric diagnoses other than schizophrenia, except bu the health controls; Subjects with schizophrenia with predominant positive symptoms; Subject illiterate or unable to complete the cognitive assessment; IQ &lt; 70; Clinically relevant suicide risk. Dropout was considered after absence in two consecutive tDCS sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-4zrwtz	Assessment of the risks and benefits of Vancomycin use in patients with infection	Recruiting	Observational	2018-01-18	<NULL>	<NULL>	1579	Evaluation of the safety and efficacy of Vancomycin use in septic patients admitted to the Clinical Hospital of the Botucatu Medical School - UNESP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4zrwtz	<NULL>	Septic patients older than 18 years using vancomycin for at least 48 hours admitted to 2 intensive care units and 4 wards (clinical and surgical). Patients using vancomycin and requiring acute renal support will be included in an additional vancomycin pharmacokinetic / pharmacodynamic research protocol	Patients under 18 years old; Pregnant women;  stage 5 CKD (creatinine clearance less than 15 mL / min, according to the MDRD formula); Kidney transplant recipients; Patients taking vancomycin for less than 48 hours and those admitted or who progressed with acute kidney injury prior to the start of their use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-358t6g	II Health diagnosis of mothers and children of Alagoas State	Data analysis completed	Observational	2018-01-18	<NULL>	<NULL>	1580	II Health Diagnosis of Maternal and Child Population of Alagoas State	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-358t6g	<NULL>	All the individuals of the maternal and child group (women of reproductive age, pregnant women, mothers, children and adolescents) residing in the selected households.	women aged over 50; male over 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9tvdnz	The effect of Aerobic Training on biological factors after Stroke	Not yet recruiting	Intervention	2018-01-18	<NULL>	<NULL>	1581	Efficacy of Aerobic Training in changing inflammatory mediators and neurotrophins and the impact on clinical outcomes in individuals with chronic vascular Stroke: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerai	https://ensaiosclinicos.gov.br/rg/RBR-9tvdnz	<NULL>	Subjects will be eligible if they have a clinical diagnosis of first or recurrent chronic stroke (&gt;6 months); are &gt; 18 years of age; are inactive or insufficiently active based on the standards of the Centers for Disease Control and Prevention adjusted activity scores on Human Activity Profile (HAP) under 74 (inactive or moderately active) and have medical permission.	Exclusion criteria will be cognitive impairments; as determined by the Mini-Mental State Exam cut-off scores; language impairments (comprehensive aphasia) and pain and/ or other adverse health conditions that might affect their performance in the intervention. Patients who use drugs or who have inflammatory or autoimmune diseases that may interfere with the concentrations of inflammatory mediators or neurotrophins will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9pc7fb	Effect of lavender essential oil on smokers with cigarette craving	Recruitment completed	Intervention	2018-01-18	<NULL>	<NULL>	1582	Evaluation of craving reduction in smokers with withdrawal syndrome under the effect of lavender essential oil	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Centro de Saúde Dr. Francisco Pinto de Oliveira	Centro de Saúde Dr. Francisco Pinto de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-9pc7fb	<NULL>	Volunteers in the smoking treatment group of the Basic Units of Family Health of the city of Campina Grande; Male and female; Over 18 years old.	Volunteers who use drugs/substances depressants of the central nervous system; diagnosis of psychiatric conditions or hypotension; hemophiliacs or who use anticoagulant substances; Do not have problems in the upper airways; which are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9vqhg7	TENS effect and exercises in menstrual pain	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1583	"TENS effect in Primary Dysmenorrhea 
and its influence on central sensitization pre and post exercise: randomized clinical trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9vqhg7	<NULL>	women; age between 11 and 35 years; pelvic pain lasting 8 to 72 hours during the menstrual period; intensity equal to or greater than 3 on the numerical scale; nulliparous.	"use of contraceptives during the study period; frequent use of analgesics or anti-inflammatories during treatment; presence of pelvic disease; pregnant; history of abortion;
musculoskeletal damage or excessive pain in any joint that may limit participation in an exercise program or evaluation of functional parameters; psychiatric disorder, cognitive decline or dementia influencing the communication process; under physiotherapeutic treatment during the study;
presence of contraindications for the use of TENS, such as ulceration or allergy to electrode material; prior use of TENS; chronic use of opioids or antidepressants; - reduction of sensitivity in the places where the electrodes will be placed; history of previous surgery in the uterus; presence of chronic decompensated diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-6txkq3	Treatment of gengival recessions with Collagen Membrane	Recruitment completed	Intervention	2018-01-19	<NULL>	<NULL>	1584	Treatment of Single Miller Class I Gingival Recessions With a Xenogeneic Collagen Matrix: a Split-Mouth Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Programa de pós-graduação em odontologia da universidade federal de Pernambuco	Programa de pós-graduação em odontologia da universidade federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6txkq3	<NULL>	Have 18 years of age or older. To present a single gingival recession in the buccal surface in at least two contralateral quadrants in the maxilla or mandible. Also considered are individuals who present more than one gingival retraction in the same hemiarco, but not adjacent ones. To possess Miller class I gingival recessions. Have good visible plaque control (visible plaque index &lt;20%).	Present active periodontal disease. Possessing systemic disorder or being on drug therapy that interferes with healing, such as uncontrolled diabetes, blood dyskinesia, the use of steroids or high doses of anti-inflammatories. Have allergy to collagen. Smoking. Pregnancy. Teeth that present non-carious or carious cervical lesion, prosthetic crowns and prominent radicular surface.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-63czrx	Effect of supplementation of nondigestible fibers and bacteria of beneficial effect to the body on blood tests, symptoms of depression and diabetes in patients with type 1 and 2 diabetes.	Not yet recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1585	Effect of prebiotic and simbiotic supplementation on lipidic and glycemic profile, inflammatory markers and symptoms of depression and anxiety in individuals with diabetes mellitus type 1 and 2: randomized clinical trial, placebo-controlled and triple blind	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-11-15	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-63czrx	<NULL>	Volunteers who are diagnosed with type 1 or type 2 diabetes mellitus; both genders; age above 19 years.	Individuals with previous gastrointestinal diseases; previous gastrointestinal surgeries; intolerances or food allergies; use of anti-inflammatory drugs or antibiotics up to three months prior to study or during study; regular use of laxatives; use of opioid narcotic analgesics; use of appetite suppressants; current or previous use up to one month of probiotic symbiotic prebiotics or products enriched with these ingredients; presenting intolerance to prebiotics or probiotics or symbiotics; pregnant or lactating women; following a diet for weight loss or gain in the last three months; current follow-up of unusual diets; alcohol dependence; illicit drugs and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-796fgc	Analysis of the trunk muscles in people with low back pain after treatment through Pilates	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1586	Electromyographic analysis of the trunk muscles in subjects with non-specific low back pain submitted to a Pilates protocol	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-11	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-796fgc	<NULL>	"Low back pain group: both sexes, nonspecific low back pain, age between 18 and 40 years;
Control group: both sexes, aged between 18 and 40 years, clinically healthy;"	Specific low back pain; congenital malformation; sensory or motor changes, illnesses that impede the performance of the exercises, Pilates exercises for less than 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9yw9fk	Manual reaching behavior training in socioenvironmental risk infants	Recruiting	Intervention	2018-01-22	<NULL>	<NULL>	1587	Effect of specific training on reaching behavior  of socioenvironmental risk infants: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9yw9fk	<NULL>	Socioeconomic risk infants with adequate birth weight for gestational age, Apgar between 7 and 10 in the first and fifth minutes, respectively, classified among classes C - E in the Brazilian Economic Classification Criteria of the Brazilian Association of Research Companies (ABEP), and which are in the &quot;less than adequate&quot; descriptive category in the Affordances Instrument in the Home Environment for Motor Development - Baby Scale (AHEMD-IS).	Infants whose medical records report the occurrence of 1) orthopedic (recent fracture) and / or musculoskeletal disorders that prevent the extension of the upper limbs, 2) visual and auditory changes, 3) cardiorespiratory changes, 4) anoxia, 5) premature birth, 6) signs of neurological complications (eg seizures, intracranial hemorrhage), 7) congenital malformations and 8) genetic syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-23h9cy	Comparison of the Acute Effects of Traditional versus Power Training on Metabolic, Cardiovascular and Psychophysiological Responses in Elderly Hypertensive Women	Data analysis completed	Intervention	2018-01-23	<NULL>	<NULL>	1588	"Comparison of the Effects of Eccentric Strength Training and Muscle Power
on Neuromuscular, Functional and Biochemical Variables in Elderly Individuals"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-17	Universidade Federal do Piauí - UFPI	Universidade Católica de Brasília - UCB	https://ensaiosclinicos.gov.br/rg/RBR-23h9cy	<NULL>	hypertensive women; with above 60 years; without experience with RT in the previous six months.	Subjects with physical disabilities; diagnosis of diabetes; CVDs; hypertension (systolic blood pressure [SBP] 180 mm Hg; diastolic blood pressure [DBP] 110 mm Hg); musculoskeletal disease; or who smoked; or abused drugs/alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-2yprts	Effectiveness of tele-rehabilitation compared to traditional physiotherapy in the treatment of stroke	Not yet recruiting	Intervention	2018-01-23	<NULL>	<NULL>	1589	Effectiveness of telereabilitation in the functional improvement, adherence and oxidative profile of people who had Stroke compared to usual care physical therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal do Ceara	Universidade Federal de Goias	https://ensaiosclinicos.gov.br/rg/RBR-2yprts	<NULL>	volunteer with age of 18 years or more; presence of caregiver; and recent stroke defined as a diagnosis of stroke within four weeks.	Cognitive deficits established by the minimum score of 20, through the Montreal Cognitive Assessment (MoCA); cognitive assessment tool;  users who did not sign the Informed Consent Form (TCLE); excessive spasticity in the affected upper extremity defined by the score&gt; 3 by the Modified Ashworth Spasticity Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-4233sv	Pain in preterm new born and physiotherapy.	Recruiting	Intervention	2018-01-23	<NULL>	<NULL>	1590	Analysis of Neonatal Pain in Premature infants with Respiratory Distress Syndrome and its influence on physiological parameters and the Physiotherapeutic treatment hemodynamic in Intensive Care Unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-05	Fundação Santa Casa de Misericórdia do Pará	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-4233sv	<NULL>	Volunteers with gestational age between 28 and 37 weeks, according to the who criteria; weight less than or equal to 2500 g; they&apos;re in use of invasive mechanical ventilation, with diagnosis of Respiratory distress syndrome and with indication for respiratory physiotherapy.	It will be excluded  premature newborns with congenital malformations, chromosomal syndromes, intracranial bleeding or clinical neurological changes of any nature; those with chest or abdominal drain; use of sedation above 2 mg/kg; in use of vasoactive drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-3byz2c	Evaluation of inflammatory substances in the blood of patients with recurrent glioblastoma in treatment with inhalation of perillyl alcohol associated with reduced carbohydrate diet and supplementation with omega 3	Not yet recruiting	Intervention	2018-01-24	<NULL>	<NULL>	1591	Evatuation of the metabolomic profile of patients with recurrent glioblastoma in treatment with perillyl alcohol intranasal administration associated with the ketogenic diet and dha suplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-26	Hospital Universitário Antônio Pedro	Instituto de Química da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3byz2c	<NULL>	Adults with glioblastoma; submitted to surgical procedure with the partial withdrawal of the tumor; who presented recurrences and are under chemotherapeutic treatment.	Participants who initiate immunotherapeutic treatment; or develop autoimmune; hepatic or renal disease; or discontinue the ketogenic diet; perillyl alcohol inhalation or supplement will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-6c7rq4	Neck rehabilitation in subjects with temporomandibular pain. A randomized controlled clinical trial	Data analysis completed	Intervention	2016-05-10	<NULL>	<NULL>	1592	Neck rehabilitation in subjects with Temporomandibular Disorders. A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de São Carlos- UFSCar	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-6c7rq4	<NULL>	Females; 18-40 years; temporomandibular disorders diagnosis; temporomandibular joint pain or masticatory muscles pain for more than three months; presence of tender points on palpation of masticatory muscles.	Subjects in dental treatment or other treatment of orofacial; rheumatic disease; tooth loss; fibromyalgia; systemic neurological sistemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-2q5wy8	Study on the use of surgical glue in the repair of cuts in the vagina	Recruiting	Intervention	2018-01-25	<NULL>	<NULL>	1593	Clinical trial on the use of glue surgical to repair episiotomies and perineal lacerations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-03	Escola de Artes Ciências e Humanidades da Universidade de São Paulo	Autarquia Municipal de Saúde de Itapecerica da Serra	https://ensaiosclinicos.gov.br/rg/RBR-2q5wy8	<NULL>	To be primiparous; have in vaginal birth with episiotomy and first and second degree perineal tears	Have vaginal birth with intact perineum; third or fourth degree perineal tears; give up to continue the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-8jczjm	Maternal trust for the prevention of diarrhea in children under five years of age: scientific research with different educational interventions	Recruitment completed	Intervention	2018-01-25	<NULL>	<NULL>	1594	Educational Interventions for the Promotion of Maternal Self-Efficacy for the Prevention of Childhood Diarrhea	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-09	Universidade da Integração Internacional da Lusofonia Afro- Brasileira (UNILAB)	Universidade da Integração Internacional da Lusofonia Afro- Brasileira (UNILAB)	https://ensaiosclinicos.gov.br/rg/RBR-8jczjm	<NULL>	Be a mother with at least one child under the age of 5, who must be accompanied or cared for at the UAPS, and have a cellular or fixed telephone.	Mother with level of schooling that limits her in the answers to the instruments and in the reading of the educational booklet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-98wzgn	Evaluation of Muscle Electrical Stimulation and Creatine Supplementation in Renal Hemodialysis Patients	Data analysis completed	Intervention	2018-01-25	<NULL>	<NULL>	1595	"Evaluation of Eletro  Neuromuscular Stimulation and Supplementation of
Creatine in Renal hemodialysis Patients"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-98wzgn	<NULL>	Patients with a diagnosis of chronic kidney disease; undergoing hemodialysis for more than 3 months; of both sexes; and aged between 18 and 59 years	Patients with neurological diseases; severe cardiovascular diseases; physical impairments (amputations, deep vein thrombosis); and patients who underwent long-term and structured high-resistance training three months prior to the date of inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-5ffbxz	Treatment with sloping treadmill to improve the physical conditioning of people with Stroke	Recruiting	Intervention	2018-01-25	<NULL>	<NULL>	1596	Effects of inclined treadmill on cardiovascular and functional parameters of individuals with Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5ffbxz	<NULL>	The participants will be selected according to the following criteria: diagnosis of the first episode of unilateral stroke (ischemic or hemorrhagic) that resulted in walking deficits; sequelae time equal to or greater than six months; age greater than 20 years and equal to or less than 70 years; ability to walk without personal assistance indoors (FAC scores equal to or greater than 3 (MEHRHOLZ et al., 2007); comfortable walking speed in the ground equal to or less than 0.9 m / s (limited community walkers), according to the classification proposed by Fulk and co-workers (2017); and ability to understand and obey simple motor commands.	Exclusion criteria will include: being in the gestational period; presenting instability in cardiac conditions (uncontrolled heart disease) and / or heart failure (New York Heart Association (NYHA) scores equal to or greater than 3 (REMME &amp; SWEDBERG, 2001); other clinical conditions affecting walking; have severe pain and / or discomfort, which impedes the performance of the proposed activities;  presented decompensations in the systemic arterial pressure, with systolic and diastolic values above, respectively, 200mmHg and 110mmHg before and / or after training (BALADY et al., 1998); and heart rate above the submaximal values allowed during training, maintained even after pauses, calculated using the formula [FCsub = 0.75 x (220-age)] (FOX III et al., 1971), where FCsub = submaximal heart rate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-88jb56	Interventions to hypertension control	Recruiting	Intervention	2018-01-26	<NULL>	<NULL>	1597	Factors associated with no control of hypertension and effectiveness of individual interventions and group for the promotion of disease control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-88jb56	<NULL>	Hypertension patients with more than 18 years old and uncontroll hypertension (blood pression rate more that 140/90 mmHg) and participed of transversal study.	Patients with secundary hypertension. Institutionalized patients, with mental illness or disabling chronic illness or a life expectancy of less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-498bnq	The effectiveness of Mometasone Furoate plus Isotonic Nasal Saline in the Elderly with  Rhinitis	Recruitment completed	Intervention	2018-01-26	<NULL>	<NULL>	1598	The evaluation of the effectiveness of Mometasone Furoate plus Isotonic Nasal Saline in Geriatric Patients with  Rhinitis: a Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Programa de Pós Graduação em Ciências Médicas da Universidade Federal Fluminense	Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-498bnq	<NULL>	Adults with symptoms of chronic rhinitis, two or more symptoms of nasal blockage, rhinorrhea, sneeze or nasal itching for 1 hour or more and for two weeks or more; age equal or above 60 years old; monitored clinically in the departament of allergy and immunology of Hospital Universitário Antônio Pedro.	Primary or secondary immunodeficiency; mechanical obstruction of upper airways; respiratory infection in the last two weeks; impossible to perform spirometry before and after bronchodilator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-4nn8j5	The effect of exercise in controlling blood pressure	Recruitment completed	Intervention	2018-01-26	<NULL>	<NULL>	1599	Effects of an exercise program on the control of cardiovascular risk factors in hypertensive patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-02	Universidade Santo Amaro	Universidade Santo Amaro	https://ensaiosclinicos.gov.br/rg/RBR-4nn8j5	<NULL>	elderly; previously sedentary for at least one year; hypertensive patients on antihypertensive medication; with medical release for the practice of mild to moderate physical exercises.	patients beyond the age range stipulated and/or unable to participate in the protocol (after medical evaluation)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-8zpy9d	Study on the effect of ginkgo biloba on weight reduction in overweight women	Recruitment completed	Intervention	2018-01-26	<NULL>	<NULL>	1600	Effect of supplementation of the Standardized Ginkgo biloba Extract in overweight women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade de Nutrição da Universidade Federal de Alagoas	Faculdade de Nutrição da Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-8zpy9d	<NULL>	Women aged between 19 and 45 years, diagnosed with overweight / obesity (&gt; 25 kg / m²) living in the Denisson Menezes, Maceió-AL, neighborhood or surroundings, who agreed to participate in the intervention protocol for 3 months.	Women who have previously used anabolic androgenic steroids or psychotropic drugs; pregnant women; infants; Individuals who presented morbid processes that resulted in prolonged hospitalization; hypertensive; And who make use of insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-2jx9r5	Efficacy of Tranexamic Acid for Dental Extractions in patients with Inherited Bleeding Disorders	Data analysis completed	Intervention	2018-01-29	<NULL>	<NULL>	1601	Topical versus systemic use of Tranexamic Acid in patients with Inherited Bleeding Disorders undergoing Dental Extractions: a multicenter study	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-03-09	Centro de Hematologia e Hemoterapia - HEMOCENTRO	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRPUSP)	https://ensaiosclinicos.gov.br/rg/RBR-2jx9r5	<NULL>	Adult patients (over 18 yrs old); Patients with inherited bleeding disorders; Male and females; Patients in follow up at Hemocentro de Campinas/UNICAMP and/or at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP); Patients who need at least one tooth to be removed;	"Patients who disagree with the terms of the informed consent; Patients who are incapable to give your own consent due to psychiatric and/or mental reasons; Under age patients (less than 18 yrs old); Pregnant women and/or breastfeeding women; Edentulous patients;
6- Hemophilic patients with inhibitors against coagulation plasmatic factors; Patients with high risk for thrombosis, or with a previous thromboembolic event; Patients who had a previous hypersensibility reaction related to tranexamic acid use; Patients who have used acetylsalicylic acid, or non-steroidal anti-inflammatory drugs up to two weeks before the dental extraction."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-4dkhh3	Initial prostate biopsy: 12 versus 20 cores - prospective study	Data analysis completed	Intervention	2018-01-29	<NULL>	<NULL>	1602	20 core transrectal prostate biopsy is the initial approach of choice in a selected group of patients with suspected prostate adenocarcinoma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de São Paulo	Fundação de Apoio à Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4dkhh3	<NULL>	"Patients referred for a prostate biopsy with suspected prostate cancer: positive
digital rectal exam findings and/or elevated serum prostatic-specific antigen levels."	Previous prostate biopsy and/or prostatic-specific antigen greater than 20 ng/ml	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-9m95rx	Effects on the heart, blood vessels, and psychological and social aspects following three types of bodybuilding training in men with high blood pressure	Data analysis completed	Intervention	2018-01-30	<NULL>	<NULL>	1603	Association of cardiovascular and functional effects of different methods of resistance training with psychosocial aspects of men with high blood pressure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Universidade Federal do vale do São Francisco	Universidade Federal do vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-9m95rx	<NULL>	Be resident in the cities of Petrolina / PE or Juazeiro / BA; present age between 40 and 60 years; be sedentary; (ABPM) with mean values of 24h, wakefulness or sleep greater than 125, or 110 mmHg, respectively in the systolic BP or greater than 75, or 70 mmHg, respectively in the diastolic BP, which characterizes the individual with BP elevated according to VI Brazilian Guidelines on Hypertension (2010); body mass index above 25 kg / m².	The BP, although elevated as highlighted in the previous item, should be controlled during resting measures performed in a laboratory environment, being lower than 160 and 105 mmHg for systolic and diastolic BP, respectively; to present systemic hypertension diagnosed; presenting cardiometabolic diseases or dysfunctions in the health history, such as musculoskeletal limitations, that may compromise physical integrity and participation in the study, mainly diseases of the cardiovascular system; make use of some type of drug related to blood pressure control during the study participation, if they use for other purposes inform the researcher; the maintenance of the proposed training frequency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-979wh3	Prevention of Acute Pancreatitis after examination of the bile ducts using only guidewire versus guidewire and contrast	Recruiting	Intervention	2018-01-30	<NULL>	<NULL>	1604	Prevention of Post ERCP Pancreatitis (PEP): Guidewire versus Guidewire and Contrast	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-979wh3	<NULL>	Consecutive patients over 18 years of age who are referred to the Radiology Center of the São José Pavilion (Biliary Endoscopy Service of Santa Casa / UFCSPA) will be included to perform CPER that, after due explanations about the study, agree to participate and sign the term of free and informed consent.	Patients who: have previously undergone endoscopic retrograde cholangiopancreatography, refuse to participate, and those whose ERCP is performed during the course of acute pancreatitis will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-2xt4yk	"A Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	Recruiting	Intervention	2018-01-30	<NULL>	<NULL>	1605	"A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter
Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital São Rafael/Monte Tabor-BA	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-2xt4yk	<NULL>	"Men and women, &gt;65 years of age;
Pathologically confirmed MCL, with documentation of monoclonal CD20+ B cells that have a chromosome translocation t(11;14)(q13;q32) and/or overexpress cyclin D1;
MCL requiring treatment and for which no prior systemic anticancer therapies have been received;
Presence of radiologically measurable lymphadenopathy or extranodal lymphoid malignancy (as defined by Lugano Classification for NHL);
Eastern Cooperative Oncology Group (ECOG) performance status of &lt; 2
Men who are sexually active and can beget children must agree to use highly effective forms of contraception during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of bendamustine, or 12 months after the last dose of rituximab, whichever is longest;
Men must agree to refrain from sperm donation during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of endamustine, or 12 months after the last dose of rituximab, whichever is longest; Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty;
Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (in accordance with national and local patient privacy regulations)"	"History of prior malignancy except for the following:
Malignancy treated with curative intent and with no evidence of active disease present for more than 2 years before screening and felt to be at low risk for recurrence by treating physician;  
Note:  Provided they meet other eligibility criteria, subjects who are receiving hormonal therapy alone are allowed to enroll on study;
Adequately treated lentigo maligna melanoma without current evidence of disease or adequately controlled nonmelanomatous skin cancer;
Adequately treated carcinoma in situ without current evidence of disease;
Subjects for whom the goal of therapy is tumor debulking before stem cell transplant;
Any history of central nervous system (CNS) lymphoma or leptomeningeal disease;
Uncontrolled autoimmune hemolytic anemia (AIHA) or idiopathic thrombocytopenic purpura (ITP);
Major surgical procedure within 28 days before first dose of study drug.  Note: If a subject had major surgery, they must have recovered adequately from any toxicity and/or complications from the 
intervention before the first dose of study drug;
Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of first dose of study drug, or any Class 3 
or 4 cardiac disease as defined by the New York Heart Association Functional Classification, or corrected QT interval (QTc) &gt; 480 msec (calculated using Friderica’s formula:  QT/RR0.33) at 
screening.  Exception: Subjects with controlled, asymptomatic atrial fibrillation during screening are allowed to enroll on study;
Absolute neutrophil count (ANC) &lt; 1.0 x 109/L or platelet count &lt; 75 x 109/L; for subjects with disease involvement in the bone marrow, ANC &lt; 0.75 x 109/L or platelet count &lt; 50 x 109/L.  Subjects will only be considered eligible if peripheral blood counts can be 
maintained independent of growth factors or transfusions during the screening period;
Total bilirubin &gt; 1.5 x upper limit of normal (ULN); or aspartate aminotransferase (AST) or 
alanine aminotransferase (ALT) &gt; 2.5 x ULN;
Estimated creatinine clearance of &lt; 50 mL/min, calculated using the formula of Cockcroft and Gault [(140-Age) • Mass (kg)/(72 • creatinine mg/dL) • multiply by 0.85 if female];
Prothrombin time/international normalized ratio (INR) or activated partial thromboplastin time (aPTT; in the absence of a Lupus anticoagulant) &gt; 2.0 x ULN; Exception:  Subjects receiving 
warfarin are excluded; however, those receiving other anticoagulant therapy who have a higher INR/aPTT may be permitted to enroll to this study after discussion
with the medical monitor;
Malabsorption syndrome, disease significantly affecting gastrointestinal function, resection of the stomach, extensive small bowel resection that is likely to affect absorption, 
symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass;
Uncontrolled active systemic fungal, bacterial, viral, or other infection (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite 
appropriate antibiotics or other treatment), or intravenous anti-infective treatment within 2 weeks before first dose of study drug;
Known history of infection with human immunodeficiency virus (HIV);
Ongoing immunosuppressive therapy, including systemic (eg, IV or oral) corticosteroids within 2 weeks before the first dose of study drug. Note: Subjects may use topical or inhaled corticosteroids or low-dose steroids as therapy for comorbid conditions. During
study participation, subjects may also receive systemic (eg, IV or oral) corticosteroids as needed for treatment-emergent comorbid conditions;
Known history of anaphylaxis or hypersensitivity to bendamustine, rituximab, or any of their 
components;
Serologic status reflecting active hepatitis B or C infection.
Subjects who are hepatitis B core antibody (anti-HBc) positive and who are surface antigen negative will need to have a negative polymerase chain reaction (PCR) result before randomization. 
Those who are hepatitis B surface antigen (HbsAg) positive or hepatitis B PCR positive will be excluded;
Subjects who are hepatitis C antibody positive will need to have a negative PCR result before randomization. Those who are hepatitis C PCR positive will be
excluded;
Received a live virus vaccination within 28 days of first dose of study drug;
History of stroke or intracranial hemorrhage within 6 months of first dose of study drug;
History of bleeding diathesis (eg, hemophilia or von Willebrand disease);
Presence of a gastrointestinal ulcer diagnosed by endoscopy within 3 months before first dose of study drug;
Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists (eg, phenprocoumon) within 7 days of first dose of study drug;
Requires treatment with a strong cytochrome P450 3A (CYP3A) inhibitor/inducer;
Requires treatment with proton-pump inhibitors (eg, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole).  Subjects receiving proton-pump inhibitors who 
switch to H2-receptor antagonists or antacids are eligible for enrollment to this study;
Concurrent participation in another therapeutic clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-2xfgdh	Low load Strength Training with Partial Restriction of Blood Flow in variables of Body Composition, Fat and Muscular Strength	Recruitment completed	Intervention	2018-01-30	<NULL>	<NULL>	1606	Impact of Reduced load Strength Training and Peripheral Vascular Occlusion on Body Composition, Blood Lipids and Muscle Strength	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Centro Universitário da Fund. Educacional Guaxupé - UNIFEG	Centro Universitário Católica de Quixadá (Unicatólica)	https://ensaiosclinicos.gov.br/rg/RBR-2xfgdh	<NULL>	Have medical release for practice; Volunteers of both sexes; Participate in all selection processes prior to the study; Have at least 6 months experience with strength training; Age greater than 18 years;	blood pressure above 160/100 mmHg; History of anemia, cerebrovascular disease, acute myocardial infarction, orthopedic disorders that impede joint movement; Deep venous thrombosis and cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-2nxt6y	The effect of  Balance Problems Treatment  in health centers	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1607	The effectiveness of the Vestibular Rehabilitation Program in primary health care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Secretaria Municipal de Saúde de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-2nxt6y	<NULL>	To be a SUS’ user; resident or worker in the areas covered by the Cabana and Vista Alegre Health Centers; be 18 years of age or older; have a medical indication to participate in the vestibular or Lian Gong Rehabilitation groups; sign the TCLE.	Presence of intellectual or physical disability or mental disorders that prevent the proposed activities in the groups; withdrawal of treatment; nonadherence to treatment with more than four absences; pregnancy; speech-language evaluation compatible with Benign Paroxysmal Positional Vertigo (BPPV).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-7js6r9	Effect of exercise on adolescent health risk factors	Not yet recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1608	Combined Physical Exercise and Cardiometabolic Risk Factors in Adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Norte do Paraná	Universidade Estadual do Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7js6r9	<NULL>	Be between 15 and 19 years old; not have recognized cardiovascular disease; no diagnosis of diabetes and hypertension; not been participating in a physical activity / exercise program for at least three months; do not present limiting conditions for the practice of physical exercises	Report stage of sexual maturation below IV, present body mass index greater than 40; do not meet pre-participation recommendations on physical tests and weekly sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-4gh83t	Hope as a process that preserves mental health	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1609	Hope as Cognitive and Behavioral process: a new Clinical Strategy for the prevention of Mental Health in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Faculdade de Medicina do ABC Paulista	Supera Ginástica Cerebral	https://ensaiosclinicos.gov.br/rg/RBR-4gh83t	<NULL>	60 years or more; both genders; voluntary participation; healthy volunteers; being integrated in a program of cognitive stimulation (cerebral gymnastics).	less than 60 years old; dementia diagnosed;  not being in a program of cognitive stimulation (cerebral gymnastics)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-9tg54c	The effect of Biodanza on people with Depression in psychosocial care centers	Recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1610	Efficacy of Biodanza in levels of Depression, Anxiety, Stress, Self-esteem and Life satisfaction in people with Depression in psychosocial care centers: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-13	Universidade Federal de Alagoas - UFAL	Universidade Federal de Alagoas - UFAL	https://ensaiosclinicos.gov.br/rg/RBR-9tg54c	<NULL>	Volunteers who are assisted in the Psychosocial Care Centers; 18 years of age or over; signs and symptoms of depression through the results of the application of the Mini International Neuropsychiatric Interview and or Beck Depression Inventory; stable and on medication for at least 12 weeks.	Volunteers in an acute stage of hallucination and dissociation; history of neurological disease affecting motor skills; recurrent epilepsy; dependence or abuse of alcohol and/or other illicit psychoactive substances; not adhere to Psychosocial Care Centers treatment during the survey period; 25% of absences in the sessions of Biodanza and in the treatment of Psychosocial Care Centers in the period of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8t7ssv	Effectiveness of nutritional intervention, based on the Trasnteorical Model for weight control, in Primary Health Care services.	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1611	Effectiveness of nutritional intervention in Primary Health Care belonging to Health Promotion Project - BH + Healthy: Belo Horizonte, Minas Gerais.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-27	Universidade Federal de Minas Gerais - UFMG	Secretaria Municipal de Saúde de Belo Horizonte -SMSBH	https://ensaiosclinicos.gov.br/rg/RBR-8t7ssv	<NULL>	For a definition of eligible criteria, are women; using frequent to service activities (frequent in the last month in physical exercises); to be 20 years old or older; to have obesity for adults - Body Mass Index (BMI) &gt;= 30 kg / m2 (WHO, 1995) and overweight for the elderly - BMI&gt; 27 kg / m2 (NSI, 1992).	Individuals with compromised mental health that prevented responding to the questionnaire and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-4rxhd4	How the Pelvic Floor Muscle influence in Posture of elderly women	Recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1612	The influence of Pelvic Floor Muscle Training in Postural Control of elderly women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	UNESP, Universidade Estadual Paulista Júlio de Mesquita Filho, Câmpus de Marília - Faculdade de Filosofia e Ciências, FFC	UNESP, Universidade Estadual Paulista Júlio de Mesquita Filho, Câmpus de Marília - Faculdade de Filosofia e Ciências, FFC	https://ensaiosclinicos.gov.br/rg/RBR-4rxhd4	<NULL>	Have, at the time of the evaluation, 60 years or more; To reside in Marília, without restriction of march or use of auxiliary devices for the same one; Ability to stand for at least 90 seconds; Cognitive ability to understand and perform the tasks requested by the examiner according to the &quot;Mini-Mental State Examination&quot; (MMSE), which requires a significant level of education, with a maximum of 30 points, 18 points for illiterate elders; 21 for the elderly with 1 to 3 years of schooling, 24 points for the elderly with 4 to 7 years of schooling and 26 points for the elderly with 8 or more years of schooling. Endurance of pelvic endurance up to 3 seconds - graded by the Pelvic Floor Functional Evaluation - AFA.	Patients who do not complete the 12 meetings; Patients who give up care;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8b9npb	PK/PD Study of InsuBiomm N (NPH Insulin) in Comparison to Humulin N in Type 1 patients (T1DM)	Not yet recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1613	Cross-over, double-blind, randomized, single dose euglycemic hyperinsulinemic clamp study to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of NPH recombinant human insulin produced by Biomm/Bioton and the reference product Humulin® N produced by Eli Lilly in type 1 diabetic patients (T1DM).	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8b9npb	<NULL>	"Be between 18 and 65 years old, inclusive;Have been diagnosed with type 1 diabetes for at least 1 year;Body Mass Index (BMI) between 18 and 30 kg / m2;Being on insulin therapy;Have basic knowledge of the disease that allows self-adjustment of the insulin doseaccording to the algorithm described in the protocol;Have positive antiGAD antibody or antiIA2 antibody positive or C-peptide levels less than 0.5ng / mL (0.2 mmol / L)
• Participants should be free of any detectable micro- and macroangiopathic complications that are clinically significant at the discretion of the investigator and any major disease other than diabetes as indicated by medical history, physical examination, electrocardiogram, or routine laboratory exams."	Type 2 diabetes;Use of any oral hypoglycemic; Any factor that opposes the inclusion criteria;Pregnant or lactating women who are breastfeeding;Participants in the use of glucocorticoids or any other medication that may interfere with glycemic control, at the discretion of the investigator;Any concomitant medical condition that may interfere with the performance of the protocol, including but not limited to CLAMP	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-592yyp	Effects of motor training in elderly clinical responses	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1614	Effects of proprioceptive training on the responses and sensorial and functional responses of elderly people with peripheral diabetic neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-10	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-592yyp	<NULL>	Age at or above 60 years, insufficiently active, absence of cognitive deficit, absence of impairment due to cardiovascular diseases limiting to exercise, absence of severely impaired visual or auditory acuity, absence of cutaneous lesions in the feet and amputations, independent walking and locomotion without auxiliary devices and absence of diagnosis of neurological disease that affects gait pattern.	Elderly persons attending another proprioceptive rehabilitation program during training or in the last three months, and those who participate in less than 75% of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-6cgx2k	Effect of TENS on pain relief after surgery	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1615	Effect of Transcutaneous Electrical Nerve Stimulation on postoperative pain relief	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6cgx2k	<NULL>	Age greater than 18 years; submitted to abdominal surgery (elective or complicated cholelithiasis, choledocholithiasis, obstructive jaundice, acute pacritatitis, acute cholestasis) and cardiac surgery that are hospitalized at the Hospital de Clínicas of UFTM; With post operative pain complaint; Ability to respond to assessment; Absence of provisional or definitive pacemaker; Sign the TCLE.	• Dehiscence or infection in the surgical incision with exposure of the injured skin; Tumors; New surgery during the intervention or death period; Supra renal disease, use of corticosteroids or steroid anti-inflammatory drugs that alter or influence the dosage of cortisol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-7xds2v	Biofeedback in improving diabetic heart health.	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1616	Cardiovascular biofeedback in autonomic neuropathy in individuals with Diabetes Mellitus type 2.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7xds2v	<NULL>	The following may be included in the study: individuals with Type 2 Diabetes mellitus of both sexes; aged 50-75 years; sedentary; no history of neurological diseases; muscular or rheumatic diseases outside the etiology of diabetes and that reside in the region of Greater Recife.	The exclusion criteria applied will be: presence of unstable angina; pacemaker; severe pneumopathies or other limiting diseases such as neoplasms; valvulopathies; advanced dementia; aortic aneurysm; renal insufficiency and decompensated heart failure. Individuals with orthopedic and / or neurological diseases that may not be able to perform the cardiopulmonary exercise test will also be excluded; besides the patients who present intellectual deficiencies that restrict them to answer the questionnaires and understand the proposed games.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-8kyq7g	Effects of adjunctive Mononitrate, an angin medication, in patients with a Schizophrenia diagnosis.	Recruitment completed	Intervention	2018-02-01	<NULL>	<NULL>	1617	Effects of adjunctive Mononitrate, a nitric oxide donor,  in outpatients with a Schizophrenia diagnosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP	Instituto Nacional de Ciência e Tecnologia  Translacional em Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8kyq7g	<NULL>	Patients of both sexes, age between 18 and 50 years, diagnosis of schizophrenia, in outpatient antipsychotic treatment without modifications in the last month and with symptoms present in the positive or negative dimensions.	Presence of relevant medical condition, such as cardiovascular diseases, severe hypertension, renal failure, liver disease, hypothyroidism, hyponatremia, B12 hypovitaminosis, previous intracranial hypertension, epilepsy, pregnancy, breastfeeding). This also includes patients who have signs and symptoms suggestive of hypotension such as blurred vision, dizziness, pallor, and cold extremities. History of hypersensitivity to organic nitrates. Diagnosis of substance use disorder according to DSM criteria, except nicotine. Patients with severe psychiatric comorbidities and who are the focus of clinical care in the recruitment period, such as major depressive episode and obsessive compulsive disorder. Patients with clinical criteria for integral hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-48yb5y	Impact of dietary supplement use of phytosterol on LDL cholesterol in children and adolescents	Recruitment completed	Intervention	2018-02-01	<NULL>	<NULL>	1618	Impact of phytosterol dietary supplementation on LDL cholesterol in dyslipidemic children and adolescents: double-blind, cross-over trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-06	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-48yb5y	<NULL>	Children and adolescents between 6 and 19 years old with LDL-cholesterol above 110mg / dL	"Presence of heart disease, obesity, diabetes, nephrotic syndrome, systemic arterial hypertension, Down syndrome, Prader-Willi syndrome, hypothyroidism, Cushing&apos;s syndrome.

Children and adolescents using lipid-lowering foods or medications such as corticosteroids, estrogens, progesterone, beta-blockers, and thiazides."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-3tnjtq	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	Data analysis completed	Intervention	2018-02-01	<NULL>	<NULL>	1619	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3tnjtq	<NULL>	healthy volunteers, both genders; age between 18 and 40 years; students of UNIFESP Baixada Santista;  minimum of 11 years of school education.	psychiatric diagnoses; obesity; dyslipidemia; cardiopathy; gestation; intellectual, visual and auditory deficiency; HIV on antiretroviral therapy; cirrhosis; renal failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5hhtrt	Efficiency of muscle training with visual support for swallowing in the elderly	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1620	Efficiency of muscle training with electrophiographic biofeedback in elderly deguidation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-19	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5hhtrt	<NULL>	The target population will consist of robust elderly; of both genders; over 60 years old; independent, with or without chronic diseases; as long as these are under control.	subjects who do not attend for more than two sessions evaluations and the biofeedback program; as well as those who develop disease that compromises swallowing, such as: disorder of the cervical osteomyelitis system; Brain vascular accidents; Neurodegenerative diseases; Systemic arterial hypertension and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5g9n5g	Effect of hip muscle strengthening in patients with Osteoarthritis of the knee.	Recruitment completed	Intervention	2018-02-02	<NULL>	<NULL>	1621	Efficacy of the strengthening of the postero lateral lateral musculature of the hip in individuals with osteoarthritis of knee.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade São Judas Tadeu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5g9n5g	<NULL>	Healthy volunteers; both genders; age between 50 and 90 years; present a medical report or radiographic evidence of OA according to the Kellgren and Lawrence scale; knee pain over the last week, be physically independent.	To present pathologies in incapacitating levels; having a diagnosis of fibromyalgia or rheumatoid arthritis; use of corticosteroid or intra-articular hyaluronic acid in the last 12 months; oral use of anti-inflammatory drugs last 2 months; participation in a neuromuscular strengthening or exercise program or other (non-pharmacological) treatment for knee OA in the last six months; prosthesis or any other surgery on the hip and knee joints; decompensated heart diseases; hearing or visual impairment. Participants were asked to refrain from seeking other forms of treatment during the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-89x588	Effects of Treadmill walking on quality of life and 6-minute walk test of institutionalized elderly	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1622	"Effects of a Treadmill program on quality of
life and functional capacity of
institutionalized elderly"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-89x588	<NULL>	Elderly institutionalized residents of the city of Marília-SP; of both sexes; aged 60 years or older; with functional impairment categories (CDF) greater than or equal to 2; without cognitive deficit in the Mental State Mini Exam according to the years of schooling (BRUCKI et al., 2003)	Individuals who refuse to sign the consent form; with untreated neurological or cardiorespiratory pathologies and / or who limit the ability to walk on the treadmill; with visual or auditory deficits incapacitating to conduct the research; and the elderly who interrupt in any Stages of intervention or evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5jz7b2	The way Dental Fluorosis is perceived by children and their relatives and the results that a new treatment promoted by a new low viscosity resin can provide to patients who have fluorosis.	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1623	Perception of Dental Fluorosis and Resin Infiltration efficacy on its esthetic treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Faculdade de Ciências da Saúde - Universidade de Brasilia	Secretaria de Educação do Governo do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-5jz7b2	<NULL>	"Presence of, at least, four anterior teeth affected by fluorosis classified as mild to moderate (2 to 5)according to Thylstrup and Fejerskov index;
Possibility of periodic return for revaluations;
Who have reported to be dissatisfied with the appearance of their teeth in the Child&apos;s and Parent&apos;s Questionnaire about Teeth Appearance"	"Presence of carious lesions on the teeth to be treated;
General and oral health that do not support clinical exam;
Dental hypersensitivity;
Presence of extensive restoration in anterior teeth that do not allow appropriate diagnosis;
Use of orthodontic appliances;
Patients with teeth affected by tetracycline stains;
Patients with anterior teeth affected by MIH;
History of allergy to any of the resin infiltrant components."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9mqzvz	Efficacy of Regenerated Oxidized Cellulose versus Calcium Alginate in Bleeding from Breast Wounds caused by Cancer	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1624	Efficacy of Regenerated Oxidized Cellulose versus Calcium Alginate in the control of Bleeding from Malignant Wounds due to Breast Cancer: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-19	Escola de Enfermagem da Universidade de São Paulo	Hospital de Câncer III do Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA	https://ensaiosclinicos.gov.br/rg/RBR-9mqzvz	<NULL>	Be 18 or older; have breast cancer with hemorrhagic wound in one or both breasts; being in stable emotional conditions that allow participation in the intervention of the study; and accept venipuncture for blood collection.	Patients who have bleeding present in the malignant wound of the breast due to arterial cause; bleeding present in the malignant wound of the breast but without visualization of the origin of the bleeding site; patients with a known allergy to the hemostatic products used in the main study intervention, and patients who have had bleeding in their malignant breast wounds, but who have already participated in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-4jg86v	Pain relief through the use of medium-frequency alternating current in healthy individuals	Recruitment completed	Intervention	2018-02-02	<NULL>	<NULL>	1625	Hypoalgesic effect frequency average in current alternating khz on health individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-28	Universidade Federal de Sergipe	Laboratório de Pesquisa em Neurociência (LAPENE) - Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4jg86v	<NULL>	Healthy, university students are included, which have no prior knowledge about the usage of this current and its effects; 18 a 60 years of ago.	They will be excluded from the sample individuals: peripheral nerve damage in the upper limbs, current pain, pregnancy, chronic diseases, cardiac pacemaker, epilepsy, allergy to the electrodes, in use of analgesics or current psychiatric, altered skin conditions or loss of sensation in the areas of placement of the electrodes and history of surgery on the forearm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9r8drp	Clinical study to evaluate the blood levels of CA-125 and CD-23 substances and the amount of nerve fibers in the endometrium in patients with pain associated with Endometriosis: before and after 6 months of use of the Levonorgestrel-Releasing Intrauterine System (progesterone hormone IUD) or the Etonogestrel Subdermal Implant (Progesterone Hormone Implant)	Not yet recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1626	A randomized clinical trial evaluating of CA-125 and CD 23 soluble  serum levels and nerve fibers in the endometrium of patients with pain associated with Endometriosis before and after 6 months of use of the Levonorgestrel-releasing Intrauterine System or the Etonogestrel Subdermal Implant	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-01	faculdade de ciencias medicas da universidade estadual de campinas	faculdade de ciencias medicas da universidade estadual de campinas	https://ensaiosclinicos.gov.br/rg/RBR-9r8drp	<NULL>	Women between age 18 to 45 years old, who entered at the study at the time of randomization and did not discontinue follow-up until the last visit in the previous study, 180 days after device insertion, these women already have a diagnosis and surgical staging or endometriosis imaging method (according to ASRM, 1997) and have reported chronic pelvic pain and / or dysmenorrhea with pain scores greater than or equal to 4 on the visual analog pain scale in the moment of randomization; agree to participate in the study and sign the informed consent term	Pregnancy; current proposoal to get pregnant; desire to only use the LNG-IUS as treatment and control of pain due to endometriosis; personal history of uterine Mullerian malformation or acquired uterine abnormalities, such as synechiae, or surgical absence of uterus; contraindications to the use of the LNG-SIU: current or recurrent pelvic inflammatory disease; acute infection of lower genital tract; present purulent cervicitis; history of miscarriage in the last three months; history of puerperal infection in the last three months; malignant uterine, cervical, hormone-dependent tumors; genital uterine bleeding with uncertain or undiagnosed etiology; conditions associated with increased susceptibility to infections; acute liver disease or malignant liver tumors; acute thromboembolism; hypersensitivity to levonorgestrel; contraindications to the use of the ENG implant: acute thromboembolism; malignant uterine tumors, hormones-dependent; genital uterine bleeding with uncertain or undiagnosed etiology; acute liver disease or malignant liver tumors; hypersensitivity to etonorgestrel or to any component of the implant; abuse of illicit drugs or alcohol; morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-2hr94r	Effect of the use of a catechin from green tea on the clinical performance of adhesives for dental restorations	Recruitment completed	Intervention	2018-02-05	<NULL>	<NULL>	1627	Effect of epigallocatechin-3-gallate (EGCG) in the clinical performance of an universal adhesive system: a randomized clinical study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Ceara	Universidade Federal do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-2hr94r	<NULL>	Be over 18 years old; Have adequate hygiene with absence of periodontal disease; Have at least 20 teeth in occlusion; To present at least four teeth with non-carious cervical lesions (erosion, abrasion and / or abfraction) under occlusion; The lesions should be expulsive, with no retentions, no more than 50% of the cavo-superficial margin in enamel and with cervical margin in dentin.	To Present bruxism;To present lesions previously restored; To present premature contacts; To present prostheses (fixed or removable) involving the teeth with LCNC.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5ss7g7	Effects of sweeteners on the blood glucose and food intake	Data analysis completed	Intervention	2018-02-05	<NULL>	<NULL>	1628	Effects of high-intensity sweeteners on glycemic response and their acute impact on food intake	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5ss7g7	<NULL>	Eligibility criteria included adult (20-40 years old), eutrophic (BMI ranging from 18.5 and 24.9 kg /m2), with adequate body fat percentage (women: 20 to 30% and men: 12 to 20%), non-consumers of sweeteners and/or diet and light products (at least once a week), no smoking habits, not be pregnant or lactating and no family history of diabetes or glucose intolerance, no allergy or aversion to food tested in the study, no use of drugs that affect glycaemia or appetite, stable weight (change &lt; 3 kg in the last 3 months) and not on a weight loss diet.	Individuals outside the specified age group and body composition, smokers, pregnant or lactating women; with glycemic changes or a family history of diabetes or glucose intolerance; users of drugs that affect glycaemia or appetite, individuals with weight instability or on a weight loss diet, as well as all volunteers who express an interest in withdrawing from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9gnpdp	Influence of the positioning of the electrodes on the pain relief provided by TENS	Recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1629	Positioning of electrodes influence on hyporalgesia induced by TENS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-26	Fundação Universidade Federal de Sergipe	Laboratório de Pesquisa em Neurociência (LAPENE) - Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9gnpdp	<NULL>	Healthy subjects; Age 18-45 years old; Agree to participate in the study	Pain; loss or damage to the nerves of the upper and lower; pregnancy; cardiac pacemaker; allergy to carbon electrodes;use of analgesic medication or psychiatric; changed conditions of the skin or loss of sensitivity in the areas of placement of the electrodes; history of current pain or surgery in the application region of TENS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-58jj2j	Data collection of patients with diagnostic of T-cell Lymphoma in the five regions in Brazil	Recruiting	Observational	2018-02-05	<NULL>	<NULL>	1630	T-cell Brazil Project: prospective collection of data in patients with T-cell Lymphomas distributed in the five distinct macro regions in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Hospital Samaritano de Sao Paulo Ltda	GEMOH- Grupo de estudos multicentricos em onco-hematologia	https://ensaiosclinicos.gov.br/rg/RBR-58jj2j	<NULL>	Date of diagnosis from January, 2015, Newly diagnosed patients with T-cell or T/NK cell peripherical lymphomas; tissue biopsies adequate for diagnosis and classification, all available for centralizes review; clinical data including baseline information on disease localization and laboratory parameters at staging, features on treatment adopted and assurance of follow up updating for at least 5 years are requested. Besides that, dated and signed consent form.	If diagnosis of Blastic NK-cell leukemia/lymphoma; Aggressive NK-cell leukemia; T-cell large granular lymphocytic leukemia; T-cell large granular lymphocytic proliferation; NK-cell large granular lymphocytic proliferation; T-cell prolymphocytic leukemia; Precursor T-cell lymphoblastic leukemia/lymphoma; mycosis fungoides; sézary syndrome; primary cutaneous ALCL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-6wnzhq	Study of Talipes Cavus after the application of Electrotherapy	Not yet recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1631	Baropodométrico study in Talipes Cavus Essentials after the passage of Symmetrical Biphasic Currents	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-6wnzhq	<NULL>	Subjects between 18 and 45 years; both genres; with the pes cavus, diagnosed with a lateral radiograph in charge with the dominant foot where the angle of the internal Bartani was determined, which should be 125º.	Having a osteoarticular, tumoral or systemic degenerative diseases; having undergone foot surgery; having received manual foot treatment of some sort in the four weeks prior to the study; Using orthopodiatric treatment for pes cavus; having had serious trauma to the foot.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-7mvgfc	"Pharmacokinetics (PK) and pharmacodynamics  (PD) 
 study of InsuBiomm R (Regular Insulin) in comparison to Humulin R in Type 1 patients"	Not yet recruiting	Intervention	2018-02-06	<NULL>	<NULL>	1632	A double-blind, randomized, clinical study with a single subcutaneous dose to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of two Regular recombinant human insulins, the test drug being the Regular Human Insulin produced by Bioton SA and the reference medicine Humulin® R produced by Eli Lilly Brasil Ltda using euglycemic and hyperinsulinemic clamp technique in type 1 diabetic research participants (PPES005/17)	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-7mvgfc	<NULL>	Be between 18 and 65 years old, inclusive;have been diagnosed with type 1 diabetes for at least 1 year;body Mass Index (BMI) between 18 and 30 kg / m2;being on insulin therapy;have basic knowledge of the disease that allows self-adjustment of the insulin dose according to the algorithm described in the protocol;h have positive anti-GAD antibody or anti-IA2 antibody positive or C-peptide levels less than 0.5ng / mL (0.2 mmol / L);participants should be free of any detectable micro- and macroangiopathic complications that are clinically significant at the discretion of the investigator and any major disease other than diabetes as indicated by medical history, physical examination, electrocardiogram, or routine laboratory exams	Type 2 diabetes;use of any oral hypoglycemic;any factor that opposes the inclusion criteria; pregnant or lactating women who are breastfeeding; participants in the use of glucocorticoids or any other medication that may interfere with glycemic control, at the discretion of the investigator; any concomitant medical condition that may interfere with the performance of the protocol, including but not limited to clamp; participant with chronic hepatopathy, chronic renal failure, renal insufficiency, congestive heart failure grade II or above; history of cancer in the last 5 years;participant with indication for any surgical procedure in the next 6 months;h history of major surgery in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9kqvnz	Short-term motor control adaptations after a Single Robotic therapy associated with the Video game	Data analysis completed	Intervention	2018-02-06	<NULL>	<NULL>	1633	Short-term sensorimotor adaptations after a single robotic therapy associated with the video game	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Universidade Federal de São Carlos	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9kqvnz	<NULL>	The individuals with hemiparesis were not linked to any rehabilitation programs and this experience was the first contact with robotic therapy. The following inclusion criteria were considered 6 or more months post-stroke; men or women aged between 50 and 75 years; low spasticity: less than level 3 on the modified Ashworth scale so that the individual would be able to perform the isokinetic test; and independent overground walking levels 2 and 5 according to the Functional Ambulation Categories. The control group participants had to score greater than 8 on the Physical Activity Questionnaire Basal, which indicates they were not sedentary. This is important because sedentary people have deleterious modifications in the neuromuscular system; individuals from the control group performed physical activity, mainly aerobic activities, at least 3 times a week. No further criteria regarding the physical activity level were used.	Clinical signs of severe heart failure or chronic metabolic disease; severe cognitive or communication impairments; minimum score on the Mini-Mental State Examination according to the education level; [19] a history of lower limb injuries, deformity or contractures of the ankle joint; a smaller range of motion than 10o for dorsiflexion and 20o for plantarflexion; sensory deficits and neglect absence defined by clinical exams. Bell’s and Clock drawing tests were used to identify the neglect. [20, 21] Six or more errors indicate visuospatial hemineglect in the Bell´s test. Concerning the Clock drawing test, neglect patients are often found to omit numbers or to place all of the numbers on the right-hand side of the clock face.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-3q2c68	The inclusion of non-drug therapy in the Nursing Process for the control of nausea / vomiting and mouth sores in patients with breast and lung Cancer undergoing chemotherapy	Recruiting	Intervention	2018-02-06	<NULL>	<NULL>	1634	The inclusion of non-drug therapy in the nursing process for the management of emesis and mucositis in patients with breast and lung Cancer submitted to chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	Departamento de Enfermagem da Universidade Estadual de São Paulo	Universidade Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3q2c68	<NULL>	Over 18 years of age;both genders;carrier of breast or lung cancer;being in adjuvant or neoadjuvant chemotherapeutic treatment;being the first chemotherapy treatment performed;to be performing the first 4 cycles of chemotherapy in the State Hospital of Botucatu.	Patients in palliative care;patients refuse to participate in the research;who not in the first 4 cycles of chemotherapy;patient with recurrence of breast and lung cancer;withdrawal of treatment;death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-775y3d	Assessment of adherence to the guidelines for the management of Obesity in patients in the line for Surgery to Reduce the Stomach	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1635	Assessment of adherence to the guidelines for self-management of Obesity in patients in the waiting line for Bariatric Surgery in SUS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Estadual Paulista `` Julio de Mesquita Filho´´ Faculdade de Ciências Farmacêuticas, Câmpus Araraquara	Fundação Faculdade Regional de Medicina de São José do Rio Preto- FUNFARME / Hospital de Base	https://ensaiosclinicos.gov.br/rg/RBR-775y3d	<NULL>	Patients with indications for bariatric surgery; aged between 18 and 65 years.	patients that are receiving care or guidance from other services for weight loss; history of alcohol or drug abuse; inflammatory cardiovascular disease in the active phase; chronic kidney disease; active cancer; severe cardiovascular disease; chronic obstructive pulmonary disease; systemic arterial hypertension that do not use medication for control; untreated thyroid disorders; severe functional limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-2zk6yc	Comparison of three methods to measure the feeding tube in newborns	Data analysis completed	Intervention	2018-02-07	<NULL>	<NULL>	1636	Length of the gastric tube in newborns: comparison between three methods of measurement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Estadual de Campinas	Caism - Hospital da Mulher Prof. Dr. José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-2zk6yc	<NULL>	"Newborn; both genres; need a gastric tube; do not present any type of congenital malformation or syndrome; have not suffered
surgical procedure in the gastrointestinal system."	"newborn who is seriously ill; under minimal care; has a medical contraindication
of nasopharyngeal tube; severe hypothermia that prevents the X-ray, ultrasonography,
weighing and length verification."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-8gcd45	Clinical Evaluation of Dental Restorations in Composite Resin made 14 years ago	Data analysis completed	Observational	2018-02-07	<NULL>	<NULL>	1637	Clinical Evaluation of Restorations in Composite Resin Packable and micro-hybrids performed 14 years ago	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia da Universidade Federal de Pernambuco	Faculdade de Odontologia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8gcd45	<NULL>	Patients with indication of restoration in at least 3 posterior teeth; good oral hygiene condition; healthy or properly restored antagonistic teeth.	Have made any changes in the restorations, replacements, repairs, prostheses; loss of dental elements analyzed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-9rpv92	Use of Glass Fiber Post in Teeth with Veneers	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1638	Use of Intracanal Fiber Post effect in the fracture resistance of Teeth with Veneers: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9rpv92	<NULL>	"Be at least 18 yaers old; good conditions of health; do not present periodontal desease;
-Have coronal darkeness, larger restorations affecting vestibular face; have antagonist and adjacent teeth; endodontical treatment with good conditions; patients that don&apos;t have sistemics deseases or allergy to materials used; absence of parafunctional habits; central or lateral maxillary incisors with need of aesthetical rehabilitation with direct veneers of composite resins."	Removable prosthesis which have support on tooth of study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-725bwg	Efficacy of a Pilates protocol for Non-specific Low Back Pain individuals	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1639	Electromyographic assessment of the trunk muscles in individuals with Non-especific Low Back Pain submitted to a Pilates protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-725bwg	<NULL>	Age between 18 and 40 years. Negative straight leg raise test. Presence of aberrant movement. Positive prone instability. Negative fear avoidance beliefs questionnaire (FABQ-W &lt;19).	Individuals with specific low back pain. Congenital malformation. Sensory or motor alterations. Individuals who do not fit the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-44jwy4	Effects of Functional Food Consumption on the Clinical and Nutritional Status of Hemodialysis Patients	Recruitment completed	Intervention	2018-02-07	<NULL>	<NULL>	1640	Effects of Green Banana and Inulin Resistant Starch Consumption on Clinical and Nutritional Status of Hemodialysis Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-44jwy4	<NULL>	age greater than 18 years; hemodialysis time greater than 6 months, being at the time of study by AVF and with adequacy of the dose indicated by Kt / V greater than 1.2.	diagnosis of intestinal diseases; use of laxative medicine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-785ghf	Comparison of two medium for semen freezing with addition of some components in order to improve the quality of spermatozoa of infertile men.	Recruiting	Intervention	2018-02-14	<NULL>	<NULL>	1641	Comparison of two medium for semen cryopreservation regarding the effects of lipid supplementation and antioxidant action on sperm viability in men with altered seminal parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina de Ribeirão Preto	Invitra	https://ensaiosclinicos.gov.br/rg/RBR-785ghf	<NULL>	Men aged 18-40 years; literate;sent to the accomplishment of the spermogram in the laboratory of Gynecology and Obstetrics; able to collect the semen by masturbation; accept to participate in the study by signing a Term of Free and Informed Consent	Semen volume smaller than or equal 1.5 ml; sperm concentration greater than 15 million / mL; progressive motility greater than 32%; azoospermia; history of cancer from any location; previous or current use of chemotherapeutics or other medications known to interfere with spermatogenesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-4vz9c4	Efficacy and Safety Study with 24-month Follow-up of Oleogel-S10 in Patients a group of inherited disorders that involve the formation of blisters following trivial trauma	Not yet recruiting	Intervention	2018-02-16	<NULL>	<NULL>	1642	"Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy
and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital da Criança Santo Antônio - Irmandade Santa Casa de Misericórdia de Porto Alegre	Inc Research Br Serviços de Pesquisa Clínica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4vz9c4	<NULL>	"Male and female patients with any subtype of inherited Epidermolyse bullosa age more than 4 years; Patients with an Epidermolyse bullosa target wound; Patient and/or his/her legal representative has/have been informed, has/have read and
understood the patient information/informed consent form, and has/have given written
informed consent; Patient and/or his/her legal representative must be able and willing to follow study
procedures and instructions."	"Epidermolyse bullosa target wound with clinical signs of local infection; Use of systemic antibiotics for wound-related infections within seven days prior to enrolment; Administration of systemic or topical steroids within 30 days before enrolment; Immunosuppressive therapy or cytotoxic chemotherapy within 60 days prior to enrolment; Patient has undergone stem cell transplant or gene therapy for the treatment of inherited EB; Current and/or former malignancy; Enrolment in any interventional study or treated with any investigational drug for any
disease within 4 weeks prior to study entry; Factors present in the patient and/or his/her legal representative that could interfere with study compliance such as inability to attend scheduled study visits or compliance with
home dressing changes; Pregnant or nursing women and women of childbearing potential including postmenarchal female adolescents not willing to use an effective form of birth control
(e.g., implant, injectable, combined oral contraceptive, intrauterine contraceptive device, sexual abstinence, vasectomised partner) during participation in the study (and at least 3 months thereafter); Patient is a member of the investigational team or his/her immediate family; Patient lives in the same household as a study participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-5684wx	The Effect of Postural Gymnastics on Flexibility and Pain Relief in Badminton Players	Recruiting	Intervention	2018-02-20	<NULL>	<NULL>	1643	The Effect of the Isostretching Method on Flexibility and Pain relief in badminton players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-26	Associação Teresinense de Ensino	Associação Teresinense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-5684wx	<NULL>	Players of both sexes; Athletes who have a link with the institutions where the research will be carried out and the athletes that are part of the Piauiense Badminton Federation;	Athletes who engage in some parallel physical activity or other sport; Athletes who present some articular deformity, neurological, respiratory disorder, difficulty understanding in performing the technique.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-34f49c	Evaluation of Quantity decreased of Bleaching Agents during tray use in the At-home Bleaching customized and prefilled trays and presence of Bleaching agents in saliva: randomized clinical trial	Recruitment completed	Intervention	2018-02-20	<NULL>	<NULL>	1644	Evaluation of Hydrogen and Carbamide Peroxides Degradation using customized and prefilled trays and presence of Peroxides in saliva: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Instituto de Ciência e Tecnologia de São José dos Campos	Instituto de Ciência e Tecnolgia	https://ensaiosclinicos.gov.br/rg/RBR-34f49c	<NULL>	Patients older than 18 years old; good general health; do not present enamel erosion, dental abfraction, caries or periodontal disease; do not use orthodontic appliance or removable prostheses; present all teeth - First Molar to First Molar (Upper and Lower); avaiability of recurring returns; absence of gingival recession; submitted to bleaching for minimum period of 2 years.	Chemically dependent patients, nonsmokers and alcoholic ; medical condition that may interefere in patients&apos; security during the study: use of drug therapy to chronic disease or allergic reaction to substances that will be used; pregnancy; participate of another study in the same time; presenting restorations in the six anterior teeth of each arch; frequent use of fluoride supplementation or desensitization substances; bruxism; periapical lesions; tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-6c65dw	Joint manipulation and electrotherapy in cervical pain	Data analysis completed	Intervention	2018-02-20	<NULL>	<NULL>	1645	Evaluation of the effects of chiropractic and transcutaneous electrical nerve stimulation (tension) on pain relief in patients with of mechanical origin neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-16	Associação Teresinense de Ensino SC LTDA	Associação Teresinense de Ensino SC LTDA	https://ensaiosclinicos.gov.br/rg/RBR-6c65dw	<NULL>	To be between 20 and 39 years of age; to be of both sexes; to have cervicalgia of mechanical origin.	Present a positive result for the klein test; acute fracture; spinal cord tumor; acute infections; malignant spinal neoplasm; frank disc herniation with signs of progressive neurological deficit; neoplasms of muscle tissue or other soft tissues; generalized congenital hypermobility; syringomyelia; hydrocephalus of unknown etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-223xv8	Investigation of PEEP-ZEEP pulmonary secretion clearance maneuver and its early effects on cardiac and respiratory systems	Recruitment completed	Intervention	2017-08-16	<NULL>	<NULL>	1646	Investigation of PEEP-ZEEP airway clearance maneuver and its early effects on hemodynamic and respiratory mechanics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-223xv8	<NULL>	Patients with pulmonary secretion on mechanical invasive ventilation; hemodynamically stable (MBP higher than 65 mmHg); PEEP lower or equal than 10 cmH2O; oxygen inspiratory fraction lower or equal than 0,4; peripheral oxygen saturation higher than 90%.	Intracranial hypertension; cor pulmonale; pulmonary hypertension; pregnancy; pneumothorax not drained; rib fractures; thoracic drain tube.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3qp5np	Mastication and sleep features study after  electro-mechanical therapies and use of intraoral device in patients with Down syndrome: evaluation of muscles, sleep and saliva.	Recruiting	Intervention	2018-02-20	<NULL>	<NULL>	1647	Evaluation of the function of the masticatory muscles and physiologic sleep variables after therapies of electro-mechanical bioestimulation and use of intraoral device in patients with Down syndrome: electromyography, polysomnography and salivary parameters.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-18	Instituto de Ciências eTecnologia ICT - Universidade Estadual Paulista Julio de Mesquita Filho - UNESP	Instituto de Ciências eTecnologia ICT - Universidade Estadual Paulista Julio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3qp5np	<NULL>	"Down Syndrome patients; both genders; snoring and mild to moderate apnea/hypoapnea index;  cognitive  status parcialy preserved; understand the verbal comands necessary to perform this research project; agree to participate by free will and must sign the Awareness Term.
  
Cognitive analysis will be realized under  simple comands, such as &quot;open the mouth&quot;, &quot;close the mouth&quot;, &quot; bite&quot;, &quot;relax&quot;. If patients be able to answear this simple comands, will be considered as part of the study."	Body mass index grater than 30; unsatisfactory dental health; not able to reach the University when is needed; have been submited to physiotherapic and orthodontic treatment at least 6 months before the begining of this study; present psychiatric disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-225ksb	Effects of muscle fatigue on knee sensitivity	Data analysis completed	Intervention	2018-02-21	<NULL>	<NULL>	1648	The influence of femoral quadriceps muscle fatigue on joint knee proprioception	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade São Judas Tadeu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-225ksb	<NULL>	Healthy volunteers, classified as active, according to the International Physical Activity Questionnaire, without previous injuries in the lower limbs.	To present pathologies in incapacitating levels; having a diagnosis of fibromyalgia or rheumatoid arthritis; participation in a neuromuscular strengthening or exercise program or other (non-pharmacological) treatment for the knee in the last six months; prosthesis or any other surgery on the hip and knee joints; decompensated heart diseases; hearing or visual impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3cj934	Effects of phototherapy on chronic low back pain	Recruiting	Intervention	2018-02-21	<NULL>	<NULL>	1649	Effects of photobiomodulation on pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3cj934	<NULL>	It will be included volunteers of both genders; adults; aged between 20 and 65 years; body mass index (BMI) between 20 and 34.9 km/m2, who are eutrophic subjects; pre-obese or with moderate obesity (degree I). Volunteers should report complaints of low back pain for a period equal or greater than 3 months, with the same intensity, irradiated or not for their lower limbs.	It will be excluded volunteers who present lumbar cancer; coagulation disorders; infection; neurological deficits; and volunteers who use anti-inflammatory; and / or analgesic drugs during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-73xvmg	Evaluation of Nasal Protectors used in the prevention of Nasal injury in premature infants submitted non-invasive ventilation	Recruitment completed	Intervention	2018-02-23	<NULL>	<NULL>	1650	Comparative analysis between Hydrocholid and Silicone Gel in the prevention of Nasal injury in pre-term newborns submitted to non-invasive mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Tecnológica Federal do Paraná	Hospital Infantil Waldemar Monastier	https://ensaiosclinicos.gov.br/rg/RBR-73xvmg	<NULL>	"Preterm newborn of both genders.
Preterm newborn without distinction of ethnicity.
Preterm newborn without distinction of class or social group.
Preterm newborn with gestational age of less than 37 weeks were submitted to non-invasive ventilation through binasal prongs as initial ventilatory support or as weaning for a minimum of 24 hours.
Preterm newborn that the parents and / or guardians sign the Informed Consent Term."	"Term neonates.
Newborns with nasal deformities.
Newborns on non-invasive ventilation for a period of less than 24 hours."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-4wz3w3	Group Therapy and Self-monitored Home Exercises to increase exercise practice in the subacute phase after Stroke - Randomized Clinical Trial	Recruiting	Intervention	2018-02-23	<NULL>	<NULL>	1651	Task-oriented Group Therapy and Home-based Exercise increase in the amount of practice in the subacute phase after Stroke - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-22	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4wz3w3	<NULL>	Individuals with the following characteristics will be included: Single and unilateral stroke proven by imaging or medical report; Maximum of 6 months after brain injury (subacute phase), able to understand simple commands, evaluated through the Mini State Mental Examination (MMSE), score higher than 18 points (illiterate) and 24 points (school instruction) (LOURENÇO; , 2006); Able to maintain standing posture, with or without an auxiliary device, evaluated by the Motor Assessment Scale (MAS), item 5, with a minimum score of 3 points.	Individuals with the following characteristics will not be included: Previous stroke with residual motor deficit; Cerebellar stroke; Other neurological diseases (such as Parkinson&apos;s Disease, Herpes Zoster, among others); Associated orthopedic problems that may interfere with mobility; Uncontrolled heart problems that may restrict your participation in activities;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8pjqh2	Effects of Melatonin on clinical manifestations, inflammation and sleep quality in patients with Rheumatoid Arthritis	Recruitment completed	Intervention	2018-02-23	<NULL>	<NULL>	1652	A randomized prospective study on the effects of chronic administration of Melatonin on clinical manifestations, oxidative stress, inflammation, and sleep-wake rhythm in patients with Rheumatoid Arthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-18	Faculdade de Medicina da Universidade Federal do Ceará	Hospital Geral Dr. César Cals	https://ensaiosclinicos.gov.br/rg/RBR-8pjqh2	<NULL>	Have a diagnosis of rheumatoid arthritis confirmed by a rheumatologist, according to international criteria; being with the disease activity stable and not having undergone a change of therapeutic regimen in the three months prior to inclusion; not have been hospitalized for eight weeks prior to inclusion; not to abuse alcohol or illicit drugs; be over 18 years of age, have no diagnosis of cardiac, hepatic or renal insufficiency, have signed the free and informed consent form. Pregnant or breastfeeding women were not included either.	Patients without a conclusive diagnosis for rheumatoid arthritis; children under 18 years of age; unstable disease or in the process of therapeutic adequacy; hospital admission history in the eight weeks prior to inclusion; history of abusive use of alcohol or illicit drugs; refusal to participate in the study; pregnant or nursing women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-6759yz	Treatment of pain and damage of the Joint of the Mandible by means of Injection of Hialuronato de Sódio Medicine	Data analysis completed	Intervention	2018-02-23	<NULL>	<NULL>	1653	Evaluation of the Efficacy of Sodium Hyaluronate Injection in the treatment of signs and symptoms of Temporomandibular Joint Dysfunctions	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6759yz	<NULL>	Individuals from 18 to 70 years; of both sexes; with clinical and imaging diagnosis of disc displacement of the temporomandibular joint with or without reduction	Patients with rheumatologic diseases, neuropathic pain or history of previous TMJ surgery, trauma or fractures; Patients previously submitted to therapy by viscossuplementation, arthroscopy or arthrocentesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-2y6qcg	The influence of Elongation based on Reich in the reduction of signs and symptoms of Anxiety	Recruitment completed	Intervention	2018-02-23	<NULL>	<NULL>	1654	The influence of Elongation Reichiano the signs and symptoms of Anxiety	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-18	Universidade Federal de Alagoas	Fundação de Amparo à Pesquisa do Estado de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-2y6qcg	<NULL>	"The criteria for inclusion for students participating in the stretching Group&apos;s reichiano be enrolled in any nursing course period UFAL (Federal University of Alagoas); be showing signs and symptoms of anxiety through MINI(Mini International Neuropsychiatric Interview)and/or IDATE(State trait anxiety inventory).
For the control group, the inclusion criteria will be the same."	"Will be deleted the students who refuse to participate in the study; who have more than one absence per month in the stretch; and that change of course during the elongation step. 
For the control group, the exclusion criteria will be the same."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-6wnxv2	Impact of Shock Wave Therapy on male sexual impotence	Recruiting	Intervention	2017-04-18	<NULL>	<NULL>	1655	Impact of Low-Intensity Extracorporeal Shock Wave Therapy in the treatment of erectile dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-6wnxv2	<NULL>	Older than 18 years; confirmed and non-disabling coronary artery disease; erectile dysfunction for more than 6 months classified as mild to moderate (IIEF&gt; 15); erectile dysfunction responsive to use 5PDEi; exclusive sexual partner; preserved libido.	Patients with uncontrolled diabetes mellitus (Glycated Hemoglobin&gt; 10%); low testosterone levels; previous radical prostatectomy or other pelvic surgeries; patients with structural abnormalities of the penis; pelvic radiation history; central and peripheral neuropathies; psychiatric disorders; using anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-5pgxys	Use of the modulated frequency system for unilateral hearing loss	Data analysis completed	Intervention	2018-02-26	<NULL>	<NULL>	1656	Unilateral hearing loss: effectiveness of the FM system	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-10	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-5pgxys	<NULL>	Individuals between 5 and 17 years old; with diagnosis of unilateral hearing loss; adapted with a hearing aid for a minimum period of one year, with daily use of 8 hours confirmed by datalogging; enrolled in regular school; after adapting to regular use of the FM System during the school period.	Diagnosis of bilateral hearing loss; not to make effective use of the hearing aid; not properly enrolled in regular school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-46kbnp	Cupping in patients with neck pain.	Not yet recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1657	Effects of cupping therapy on myofascial trigger points in the upper trapezius muscle of patients with chronic neck pain.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-46kbnp	<NULL>	"Neck Disability Index (NDI) score&gt;5 points and punctuation on the Numeric Rating Scale (NRS) &gt; 3;
Present bilateral and active trigger point, centrally located in the trapezius muscle descendent fibers."	The exclusion criteria adopted in the present study will be individuals with a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; have undergone physiotherapeutic treatment in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-7fnsww	Time course of changes in Achilles tendon properties during 10 minute of stretching	Recruitment completed	Intervention	2018-02-26	<NULL>	<NULL>	1658	Time course of changes in passive properties of triceps surae muscle-tendon unit during 10 minute of passive static stretching	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Escola de Educação Física, Fisioterapia e Dança da UFRGS	Escola de Educação Física, Fisioterapia e Dança da UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-7fnsww	<NULL>	Young adults; Age between 18 and 40 years old; Physically active subjects	Perform strength or flexibility training in the last six months; previous history of musculoskeletal injury in lower limbs which interfere in test performance; continuous pain in lower members;  joint hypermobility; continuous use of anti-inflammatories, analgesics and muscle relaxants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3d296r	A study comparing maintenance and resection of retropatellar fat in the knee prosthesis	Recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1659	Comparative study between maintenance and resection of retropatellar fat pad in total knee arthroplasty; Clinical functional evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-12	Universidade Federal de Minas Gerais	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-3d296r	<NULL>	Voluntary patients who spontaneously accept and sign the Term of Free and Informed Consent, the TCLE, after succinct explanation by the researcher; above 55 years; both sexes; patients with osteoarthrosis, primary or secondary to osteonecrosis, or vicious fracture consolidation; committed to perform the standard protocol of postoperative rehabilitation.	Voluntary patients with inflammatory joint disease; with a low preoperative patella, diagnosed radiologically by the Insall-Salvati index; with knee flexion above 15 degrees and limitation of flexion above 90 degrees, preoperatively.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-2s58pz	Supplementation of serum whey proteins in elderly diabetic type 2 subjects submitted to a program of bodybuilding exercises as a strategy for muscle preservation and blood glucose control: controlled clinical research	Not yet recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1660	Supplementation of whey protein in type 2 diabetic elderly subjects submitted to a resisted exercise program as strategy to preserve lean mass and blood glucose control: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2s58pz	<NULL>	"Volunteers aged 65-89 years; both sexes; good physical and mental condition; creatinine tests less than 3 months within the reference values;
To present DM type 2;"	"Diagnosis of renal and / or hepatic disease;Protein consumption above daily recommendation;Use of medications that interfere with the absorption of amino acids;Use of Insulin;
Contraindication for the practice of strength exercises;Practice of resisted exercises."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8btc25	Effects of Aquatic Exercise on cardiovascular risk factors and cardiac autonomic modulation of postmenopausal women with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	1661	Effect of Aquatic Exercise on the autonomic modulation of the heart rate of postmenopausal women with Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade de Marília	Universidade Estadual Paulista - Faculdade de Filosofia e Ciência - Campus Marília	https://ensaiosclinicos.gov.br/rg/RBR-8btc25	<NULL>	Being a woman between the ages of 50 and 85 years; amenorrhea for at least 12 months (postmenopausal state); not having performed systematic exercise in the last 3 months; presenting a diagnosis of type 2 diabetes mellitus for at least 3 years.	Inability to enter and exit pool independent; inability to understand and attend simple verbal command; amputations and / or prosthesis use in limbs; sequelae of stroke; Parkinson&apos;s disease; fractures in lower limbs and / or spine after age 60; incapacitating labyrinth; otitis; hydrophobicity; skin lesions; deformity of the feet. criteria of non-inclusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3cwrdv	Asperisation of the dental cavity to improve the adhesion of composite resin restorations in patients with proximal teeth lesions of the gingiva	Not yet recruiting	Intervention	2018-02-27	<NULL>	<NULL>	1662	Asperisation of the dental cavity to maximize the adhesion of Composite Resin Restoration in patients with Non-Carious Cervical Lesions (LCNC) - using a Universal Adhesive System in the conventional and self-etching mode: Double Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-25	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3cwrdv	<NULL>	Patients older than 18 years will be included; presence of at least four LCNCs per patient, regardless of their location in the dental arch; adequate oral hygiene, and absence of driving difficulties that prevent adequate oral hygiene; absence of periodontal disease, active carious lesions and parafunctional habits, at least 20 teeth in function; absence of active staples of removable partial dentures in the teeth included in the research, and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Will be excluded: patients who do not agree with the terms of the survey; patients who do not feel motivated to participate in the research and maintain oral hygiene; patients who have difficulty attending the posterior controls of the restoration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-778wr4	Effects of Physical Exercises in Group and at Home for the Elderly	Recruiting	Intervention	2017-10-02	<NULL>	<NULL>	1663	Effectiveness of a Supervised and Unsupervised Exercise Program for the Elderly: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sagrado Coração	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-778wr4	<NULL>	Fragile elderly; Age above 60 years; Both sexes; Any level of schooling	Severe cognitive impairment; Severe motor impairment; Severe hearing deficit; Severe vision deficit; Temporary or permanent incapacity to wander; Elderly in the terminal stage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-4t46ry	Adherence to DASH dietary pattern and this effect on postpartum weight retention, at primary health care, in Manguinhos - Rio de Janeiro, RJ	Recruitment completed	Intervention	2017-01-02	<NULL>	<NULL>	1664	Proposal of prenatal nutritional assistance in primary health care, at Manguinhos	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-08	Fundação Oswaldo Cruz	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4t46ry	<NULL>	Women; in the period 06-09 months postpartum; who have any weight retention; &gt;18 years old; single fetus pregnancy; infant alive; without chronic diseases diagnosis (except obesity).	Women with chronic diseases (except obesity); in use of medicine that affects weight; who have eating disorders history; have had bariatric surgery; present an allergic manifestation to the diet; get pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-393m7m	Result of massage on recovery of athletes after street racing.	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1665	The effect of massage therapy on the recovery of runners after sports: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-30	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-393m7m	<NULL>	volunteers with age of 18 and 60, both men and women, have been practicing street racing for at least a year, accustomed to running more than 10 km continuously, to practice at least twice a week and not to have had muscle in last 6 months.	Not having heart disease, diabetes, hypertension, musculoskeletal diseases in the lower limbs in the last six months, without presence of cutaneous lesions in the region of the quadriceps muscle, not presenting severe metabolic or respiratory disorders, cramp, during the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8rcfp6	Older women with urinary loss: program with Physical Exercise and Physiotherapy	Not yet recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1666	Older women with urinary incontinence: evaluation and intervention through physical exercise and physiotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8rcfp6	<NULL>	Being female, between 60 an75 years of age, without cognitive impairment, without pelvic dysfunction, with functional assessment of the pelvic floor (AFA) greater or equal 2 (presence of contraction of small intensity, but that sustains itself).	Those that present self-reported clinical restraint for the practice of resisted exercise, cardiovascular, osteoarticular or neurological activities will be excluded, being or practicing resistance exercises in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-2nch7x	Effect of Different Types of Implants on the Total Mandible Rehabilitation	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1667	Titamax® and Helix® Implants in Protocol Procedures. A Clinical, Controlled, Randomized, Double-Blind and Multicentric Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2nch7x	<NULL>	Age between 18 and 60 years; Necessity of Lower total rehabilitation with osseointegrated implants; To present bone availability associated to the region between the mentual foramen enough for installation of a conventional implant; Presence of good systemic health; All implants should have at least 45N of insertion torque, to allow immediate loading of the implants.	Smokers and former smokers; Diabetics; Patients who use drugs or had pathologies that alter bone metabolism; Patients who use chronically anti-inflammatory and antibiotics drugs; Bruxism; Etilistis; Chemical dependents; Pregnant or wishing to become pregnant next year; History of radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-3t56dh	Evaluation of the training of physiotherapists in end-of-life care and how they apply their skills	Recruiting	Observational	2018-03-01	<NULL>	<NULL>	1668	Evaluation of the training of physiotherapists in palliative care and how they develop their professional skills	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Estadual de Campinas (Unicamp) - Faculdade de Ciências Médicas (FCM)	Universidade Estadual de Campinas (Unicamp) - Faculdade de Ciências Médicas (FCM)	https://ensaiosclinicos.gov.br/rg/RBR-3t56dh	<NULL>	Healthy volunteers; trained in physiotherapy; independent of the year of graduation; whether or not you have a postgraduate degree; both genders; age between 18 and 80 years; perform their function in a hospital environment.	Volunteers who do not agree to participate in the research; not have registered in the Regional Council of Physical Therapy and Occupational Therapy; not working in a hospital environment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-6hvjnq	Effect of acupuncture on pain and inflammatory mediators in patients with fibromyalgia	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1669	Fibromyalgia: studies involving pathophysiological mechanisms associated with pain, inflammation and muscle damage and the potential effect of acupuncture on these processes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Santa Maria/Pro-Reitoria de Pós-Graduação	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6hvjnq	<NULL>	"Women;
Age between 20 and 60 years old;
Diagnosis of fibromyalgia according to the American College of Rheumatology criteria."	"Severe psychiatric illness;
With neurological or sensory deficit;
Patients who have contraindications to acupuncture;
Pregnant women;
Lactating;
Patients unable to attend the acupuncture sessions;
Patients who do not accept the conditions proposed in the term of free and informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4qd567	How Physical Exercise influences the Perception of Pain of women with Chronic Pelvic Pain	Data analysis completed	Intervention	2018-03-02	<NULL>	<NULL>	1670	Effects of Exercise Therapy on Pain Threshold in Chronic Pelvic Pain women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qd567	<NULL>	"Study group: women of reproductive age with chronic pelvic pain;
Control group: apparently healthy reproductive age women."	Pregnant women; physically active in competitive level; malignancies, dyspareunia and/or isolated dysmenorrhea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-9w7vxd	Effect of wheelchair basketball for people with disabilities on thermogenesis	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1671	Wheelchair basketball for people with disabilities in Mato Grosso: thermogenesis, health, sports, accessibility and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-09	Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso-UFMT	https://ensaiosclinicos.gov.br/rg/RBR-9w7vxd	<NULL>	"voluntary gender male of the 18-60 years old, non smokers, with good capacity of upper limbs is preserved. Good intellectual understanding
Sign the informed consent form (SICF).
With medical certificate for sports practice assessing their clinical state of health for the sport of the research."	People with disabilities without sporting ability or affinities with sport. Time less than 18 months of injury. With lesions above C7, severe one cruve or two curve scolios with greater Cobbi angles 35 graus. with unstable osteometallic fixation. Weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4qn7t8	Observational study of spermogram normal values  of the Brazilian population	Recruiting	Observational	2018-03-02	<NULL>	<NULL>	1672	The seminal profile of the Brazilian population	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Sociedade Brasileira de Urologia	Sociedade Brasileira de Urologia	https://ensaiosclinicos.gov.br/rg/RBR-4qn7t8	<NULL>	"Participants in the study will seek urology clinics and sign the Informed Consent Term, in agreement with the methodology proposed in this study. Seminal samples of 692 patients aged 20 to 49 years from all regions of Brazil will be evaluated, following the following distribution, according to the demographic distribution of the Brazilian population described by CENSO 2010; Statistics applied to social sciences:
North Region (8.2%): 57
Northeast Region (26.8%): 185
Central West Region (7.8%): 54
Southeast Region (42.8%): 296
South Region (14.4%): 100
Samples will be obtained by masturbation, after three to five days of ejaculatory abstinence, collected in a sterile plastic bottle and immediately sent to the andrology laboratory."	Samples collected outside the proposed ejaculatory withdrawal window or under non-sterile conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-27fpmt	Comparison of the efficacy and safety of surgical laser with electrocautery in the treatment of gingiva increase by denture	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1673	Comparison of the efficacy and safety of diode surgical laser with electrocautery in the treatment of inflammatory fibrous hyperplasia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade federal de Minas Gerais	Universidade federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-27fpmt	<NULL>	Healthy volunteers; age greater than 18 years; both genders; with clinical diagnosis inflammatory fibrous hyperplasia.	Volunteers using analgesic medication; with systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-7ybwkm	Clinical evaluation in humans of alveolar bone preservation after filling by bovine composite bone substitute	Data analysis completed	Intervention	2018-03-02	<NULL>	<NULL>	1674	Evaluation of the maintenance of alveolar bone volume in humans, after filling with bone composite of bovine origin, clinical evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Faculdade de Odontologia de Araçatuba - UNESP	Centro de Pesquisas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-7ybwkm	<NULL>	Healthy patients, surgical risk ASA I; requiring extraction of a single uniradicualar tooth for posterior placement of osseointegrated implant; without periapical lesion; or periodontal disease; and preserved alveolus with 5 wall after the surgical procedure of tooth extraction.	Patients with incompatible age established by the study; patients with systemic diseases; smoking patients; patients with periodontal disease or periapical lesion; and patients who after the exodontia procedure did not present the alveolus preserved with 5 walls.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-6fsy6z	Clinical Evaluation of Composite Resin Restaurations Posterior Teeth	Recruitment completed	Intervention	2018-03-05	<NULL>	<NULL>	1675	Clinical Behavior of Composite Resin Restauarations of Oclusal Cavities in Posterior Teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-04	Universidade Federal de Pernambuco	Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-6fsy6z	<NULL>	Patients should be 17 years of age or older, have a need for restorative treatment on occlusal surfaces of at least four posterior teeth, and dental elements that antagonize restorations should be healthy or satisfactorily restored.	Patients with dental elements antagonistic to non-healthy restorations were excluded; not satisfactorily restored; restored with ceramic material and missing or removable / movable prosthetic parts holders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-55jwmp	Treatment of dental Caries using laser	Recruitment completed	Intervention	2018-03-06	<NULL>	<NULL>	1676	Influence of antimicrobial photodynamic therapy on carious lesion. Clinical analysis of the restorations and microbiological analysis of dentin	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55jwmp	<NULL>	The children analyzed in the study should be aged between 6 and 9 years of both genders and should have at least one lesion of active class I caries in homologous molars. It is necessary that this lesion reaches the dentin being deep or medium. The lesion should cover only the occlusal surface (Class I) considering that the pulp is vital and there is no sealant; amalgam or composite resin restorations in the study tooth.	Children who have teeth changes such as pain; spontaneous sensitivity; fistula; edema; mobility not compatible with stage of rhizolysis and present in the radiographic examination the presence of radiolucency in the region of furca and periápice; increased periodontal space and internal / external dental resorption will not be selected for the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4dvx2p	Study about new device for urinary incontinece	Data analysis completed	Intervention	2018-03-06	<NULL>	<NULL>	1677	SUPERA: Permanent, Removable and Self-Sustaining Urethral Probe for the Treatment of Incontinence and Urinary Retention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco - HC-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-4dvx2p	<NULL>	Female patients with neurogenic bladder and participants in the clean intermittent catheterization program.	Patients with urethral deformities and active urinary tract infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-8httxs	The use of Cloth with antiseptic before surgery to prevent Surgical Site Infection	Recruitment completed	Intervention	2018-03-08	<NULL>	<NULL>	1678	The use of Cloth Impregnated with 2% Chlorhexidine of Preoperative: Prevention of Surgical Site Infection	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-23	Escola de Enfermagem da Universidade de São Paulo - EEUSP	Hospital de Clínicas da Universidade Federal do Paraná - HC/UFPR	https://ensaiosclinicos.gov.br/rg/RBR-8httxs	<NULL>	Patients with 18 years old or more; literate; submetted elective surgeries potentially contaminated; admitted on the same day of the surgical procedure or at most with three days of hospitalization prior to surgery; absence of infectious or inflammatory process; to use  correctly cloths antisseptic 2% CHG and 2% CHG conventional (liquid)	Patients submitted to previous surgeries, in a period bottom the 30 days, or 90 days when implant of prosthesis; presence of skin lesions or known allergy to 2% CHG; make used daily of products containing antiseptics (creams and / or liquid soaps or bar soaps containing chlorhexidine gluconate, triclosan or similar) in their daily activity; use of antibiotics or similar drugs two weeks before and during the period of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-3pmndt	Influence of Therapeutic Exercise on the balance, strength and functionality of the Elderly	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1679	Influence of Kinesiotherapy on variables of postural control and validation of an instrument for evaluation of isokinetic strength in the Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3pmndt	<NULL>	Individuals 60 years of age or older; able to practice the proposed activities and evaluations; availability to participate in activities twice a week; absence of medical contraindications to the exercises; signing of the Term of Free Consent and Enlightened.	Inability to maintain standing and gait posture; which is necessary for the performance of the tests; with neurological disorders; urinary or fecal incontinence, renal insufficiency; infectious diseases, use of probes; vascular thrombus or heart failure; individuals With uncontrolled blood pressure; minimal exertion dyspnea, dementia; participation in 80% of the treatment; participation in another program of physical activity and physiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4xyyn6	The effects of comfrey in subjects with Neuropathic Ulcers for Diabetes	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1680	Effects of external use of Comfrey on Neuropathic Ulcers for Diabetes at the stomatherapy ambulatory of the hospital of education of the quaternary public network	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital Geral de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4xyyn6	<NULL>	Volunteers with neuropathic ulcer due to diabetes accompanied at the General Hospital of Fortaleza; both genders; non smokers; age above 18 years;	Volunteer smokers; Diagnosis of cancer; Diagnosis of hepatic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-6mk5n4	Study to evaluate the efficacy and safety of treatment of Cutaneous Leishmaniasis with Meglumine Antimonate applied directly to the lesion or Intramuscularly / Intravenously in several states of Brazil	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1681	Multicenter study evaluating the efficacy and safety of Intralesional administration of Meglumine Antimoniate compared to Systemic treatment for Cutaneous Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-12-01	Instituto Nacional de Infectologia Evandro Chagas (INI) -Fiocruz	Instituto Nacional de Infectologia Evandro Chagas (INI) -Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-6mk5n4	<NULL>	"Inclusion criteria 
Patients who are able to sign the informed consent and willing to participate in the study as subjects attending the follow-up visits as foreseen by the study schedule;
Patients who present up to a maximum of three lesions with or without ulceration;
Patients with confirmed parasitic infection by Leishmania by scraping or imprint or histopathological examination or culture or immunohistochemistry or by polymerase chain reaction;
Patients who present lesions with a maximum of 5 cm in diameter for a single lesion or up to 3 cm for two lesions or up to 2 cm  in the case of three lesions;"	"Women of childbearing age who do not use contraceptive methods or do so improperly;
Pregnant Women;
Children under the age of 13;
Patients with lesions in the cephalic segment;
Patients who have had previous treatment with MA;
Patients with disseminated or diffuse or recidiva cutis leishmaniasis;
Patients with of any form of leishmaniasis with mucous membrane involvement;
Patients with concomitant use of any medication with recognized toxic interactions with Sb5+ which cannot be substituted over the study period;
Patients with comorbid conditions such as heart or kidney or liver diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-2w7wkb	Chronic Heart Failure Remote Monitoring Application	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1682	HF in POCKET: Chronic Heart Failure Remote Monitoring Application	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Programa de Pós Graduação em Ciências Cardiovasculares	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2w7wkb	<NULL>	Patients with a medical diagnosis of HF regardless of etiology; normal or decreased ejection fraction; older than 18 years; with functional classes I-III NYHA; participating in consultations at the specialized clinic	Patients with cognitive neurological sequelae self-reported or identified during the multidisciplinary consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-9c3ssc	Effect of telephone consultation associated with short messaging service (SMS) in patients with heart failure	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1683	Effect of telephone consultation associated with short messaging service (SMS) on self-care, adherence and quality of life of patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9c3ssc	<NULL>	Patients older than 18 years; with medical diagnosis of HF, regardless of etiology; have face-to-face service with the multiprofessional team of the specialized IC clinic, since the telephone consultation and the SMS service work with the reinforcement of face-to-face orientations; preserved or diminished ejection fraction; functional class I-III (NYHA) and signing of the informed consent form.	patients with cognitive neurological sequelae who did not have direct telephone contact	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-33wf46	Effect of ingestion of yacon syrup in human	Not yet recruiting	Intervention	2018-03-12	<NULL>	<NULL>	1684	Metabolic benefits of nutraceuticals in human health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Fundação Universidade Estadual do Ceará FUNECE	Empresa Brasileira de Pesquisa Agropecuária	https://ensaiosclinicos.gov.br/rg/RBR-33wf46	<NULL>	Women; between 20 and 40 years old; do not present chronic self-reported diseases; have a body mass index of eutrophy or obesity grade I; regular menstrual cycle.	Pregnancy or lactation; hysterectomy performed; current smoker or in the last 30 days; users of illicit drugs; daily consumption of ethanol higher than 15g; current or last 30 days use of hypoglycemic, lipid-lowering, antibiotic and anti-inflammatory medications, laxatives or weight-loss medications; have inflammatory diseases such as inflammatory bowel disease (Crohn&apos;s disease, ulcerative colitis); endocrinopathy carrier’s (cushing&apos;s syndrome, hypothyroidism), cancer carrier’s, having celiac disease or lactose intolerance; have constipation history; present current consumption and in the last 30 days of fiber and fructooligosaccharides supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-344jq8	Assessment of applicability and results of nerve electrical stimulation in the treatment of children with intractable intestinal constipation	Recruiting	Intervention	2018-03-13	<NULL>	<NULL>	1685	Evaluation of applicability and clinical outcomes transcutaneous electrical nerve stimulation posterior treatment of children with constipation intractable intestinal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-344jq8	<NULL>	Patients between the ages of 7 and 18 years of age, of both sexes, with a diagnosis of CIC, established according to the criteria of Rome IV, and classified as having intractable intestinal constipation, according to the definition of the European Societies ( ESPGHAN) and North American (NASPGHAN) Gastropediatrics, represented by patients unresponsive to standard treatment, after a period of threE months	"Patients whose parents and / or guardians do not agree to participate in the study and who do not sign the Free and Informed Consent Term, as well as patients between the ages of 12 and 18 who do not sign their consent form, will be excluded. Patients with any identifiable organic cause for intestinal constipation will be excluded from the study. Exclusion criteria will also be considered: neurological and / or cognitive deficits, skin lesions in the region of application of electrodes, changes in local sensitivity, presence of cardiac pacemaker, children presenting with cardiac arrhythmias or cardiac arrhythmias, patients presenting incomplete questionnaires or that are subject to drug changes and the standard
during the intervention period or who abandon the proposed electrostimulation treatment during the intervention period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-8dnw3g	Evaluation of chia seed in the improvement of oxidative stress in obese children and its relation with Vitamin E.	Recruitment completed	Intervention	2018-03-14	<NULL>	<NULL>	1686	Evaluation of Oxidative Stress in Obese Children with Chia Seed Treatment (Salvia Hispanica) and its Implications for Vitamin E	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-05	Faculdade de Medicina do ABC - FMABC	Faculdade de Medicina do ABC - FMABC	https://ensaiosclinicos.gov.br/rg/RBR-8dnw3g	<NULL>	Children in the pre-pubertal age of 5 to 10 years, with a 95th percentile greater.	Serological comorbidities (HIV, Hepatitis B, Hepatitis C), neoplasms, inflammatory diseases and patients who have been hospitalized in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-59m3sj	The Analgesia of Pregabalin and Magnesium Sulphate in the postoperative period of Mastectomy with Axillary Lymphadenectomy	Recruitment completed	Intervention	2018-03-14	<NULL>	<NULL>	1687	The Analgesic Effect of Pregabalin and Magnesium Sulfate in the postoperative period of  Mastectomy with Axillary Lymphadenectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-59m3sj	<NULL>	women over eighteen years of age; indicated the mastectomy with axillary lymphadenectomy; state physical classification of the American Society of Anesthesiologist (ASA) I and II; with the signed free informed consent form; no history of allergy to pregabalin or magnesium.	patients with previous history of liver or kidney disease or any other pathology that contraindicated the use of pregabalin or magnesium; who had used opioids 48 hours before surgery. patient who would perform breast reconstruction at the same surgical time. patients using calcium channel blockers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-6qd4j3	Memory workshops with elderly women: influences on daily activities and quality of life	Recruitment completed	Intervention	2017-04-10	<NULL>	<NULL>	1688	Memory workshops with elderly women: repercussions on occupational performance and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6qd4j3	<NULL>	Being a female elderly; presenting age from 60 years old; is enrolled in the UnATI / UFPE in the period corresponding to the study; does not present cognitive and / or communication impairment that makes it impossible to conduct the data collection.	Seniors who already participate in courses of memory workshops offered or not by said institution; Possible diagnosis of depression; Use of benzodiazepines and / or memory-stimulating drugs; Elderly people with severe hearing, visual and motor impairments not compensated for wearing glasses, hearing aids and assistive technology equipment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-4kxxd5	Parental orientation for sleep problems in childhood	Data analysis completed	Intervention	2017-03-27	<NULL>	<NULL>	1689	Behavioral intervention  for sleep problems in childhood	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-04	Instituto de Psicologia da Universidade de São Paulo	Instituto de Psicologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4kxxd5	<NULL>	Parents / caregivers of children from one to five years of age who have behavioral problems related to sleep. The child must have any of the following characteristics listed below at a frequency of at least three times a week. The child takes about 30 minutes or more to fall asleep; The child resists and / or protests to go to bed; The child wakes up at night; The child only sleeps in the presence of the parents.	Children with neurological impairment; Children with psychiatric diagnosis; Children whose sleep problems are due to physiological conditions and children whose caregivers could not attend face-to-face sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-4n4c4z	Correction of umbilical hernia with anterior muscle tissue compared to posterior muscular tissue	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	1690	Umbilical herniaplasty onlay versus sublay	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital Presidente Vargas	Hospital Presidente Vargas	https://ensaiosclinicos.gov.br/rg/RBR-4n4c4z	<NULL>	Female patients; 18 years of age or older; presenting with primary umbilical hernia.	Patients with relapsed umbilical hernia; need for another concomitant surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-736xwr	Stomach Reduction with Interposition of the Small Intestine for the Treatment of Type 2 Diabetes Mellitus	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	1691	Ileal interposition associated to a  sleeve gastrectomy  for the treatment of type 2 Diabetes Mellitus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-21	Hospital Federal de Bonsucesso	Hospital Federal de Bonsucesso	https://ensaiosclinicos.gov.br/rg/RBR-736xwr	<NULL>	Documented diagnosis of type 2 diabetes mellitus; Patients of both sexes treated with oral antidiabetic agents and / or insulins; Stable antidiabetic medication in the last 8 weeks prior to selection, if the therapy includes insulin, the mean daily dose should not have been changed by more than 10% in the last 8 weeks; HbA1c&gt; 7.0%; Age&gt; 20 years and &lt;65 years;Body mass index (BMI) of 25 to 35 kg / m²; Agree to sign the TCLE;	Diabetes mellitus type 1 (anti-GAD positive) or anti-GAD negative body with low ?-cell function (peptide C after stimulation &lt;0.5 ng / ml); Recent vascular event (myocardial infarction, coronary angioplasty or encephalic vascular accident in the last 6 months); Malignant neoplasm; Portal hypertension; Difficulty to cooperate with segment; Low ability to understand surgery; Unrealistic expectations of results; Cognitive deficit; Current pregnancy; Moderate or severe mood disorder; severe anxiety; eating disorders (based on DSM-V criteria); Chemical dependence or alcoholism (based on DSM-V criteria).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-53x476	Immediate effects of Electrostimulation on vessel enlargement by the reaction of the cells on their wall and on the cellular signals of healthy and people with heart disease	Recruitment completed	Intervention	2018-03-31	<NULL>	<NULL>	1692	Acute effects of Electrical Stimulation on endothelium-dependent vasodilation and biochemical markers of healthy and cardiac	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-10	Faculdade de Ceilândia da Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-53x476	<NULL>	Inclusion criterias for healthy subjects were aged &gt; 45 years; absence of previous history of disease or surgical procedure and functional alterations during initial assessment or found in anaminesis that may interfere with the assessment of FMD. The criterias for chagasic subjects were aged &gt; 45 years; consistent symptoms with chagasic heart failure III-IV classes of New York Heart Association (NYHA); stable heart failure drug therapy; left ventricular ejection fraction &lt; 45%.	Exclusion criterias for healthy subjects were complications or cognitive/psychiatric disorders that hinder the realization of the protocol; electrical stimulation intolerance. The exclusion criterias for chagasic subjects were decompensated heart failure; uncontrolled diabetes; history of recent infection (last 03 months); corticosteroid use (last 03 months); valvular heart disease; unstable angina; acute myocardial infarction (last 03 months); obstructive hypertrophic cardiomyopathy; heart failure due to pericardial disease or corrected valvular disease; history of pulmonary / smoking disease (last 12 months); peripheral vascular disease; chronic use of oxygen therapy; previous implantation of a pacemaker or cardiac defibrillator; and systolic blood pressure at rest &gt; 200 mmHg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-6cn5t7	Study of the Biofilm of Total Dentures Fixed by Dental Implants	Recruiting	Observational	2018-03-14	<NULL>	<NULL>	1693	Clinical study of the Biofilm of Fixed Total Implanted Prostheses	<NULL>	0, n/a, n/a	0	<NULL>	<NULL>	<NULL>	2018-02-15	Departamento de Clínica Odontológica da Universidade Federal do Ceará	Departamento de Clínica Odontológica da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6cn5t7	<NULL>	The inclusion criteria for the selection of the patients are: adults; any genus; fully edentulous in the mandibular arch; with good general health; users of definitive prosthesis type made with base and artificial teeth of acrylic resin with a minimum of 6 months of last maintenance.	Exclusion criteria will be: use of antibiotics in the last 3 months; diabetes; problems associated with immunosuppression; xerostomia; motor or cognitive problems; fracture or repair in the base of the prosthesis and loose teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-8c33jx	The effect of the Pilates Method on Balance and Posture of the elderly	Recruitment completed	Intervention	2018-03-31	<NULL>	<NULL>	1694	Analysis of the Balance and Posture of the elderly before and after an intervention by the Pilates Method	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-11	Universidade Federal do Pampa	Universidade Federal do Pampa	https://ensaiosclinicos.gov.br/rg/RBR-8c33jx	<NULL>	Volunteers of both genders, aged 60 or over, ability to stand and walk independently.	Volunteers who have any type of amputation; have been performing physical activity in the last 6 months without interruption; have diagnostic or self-reported rheumatoid arthritis; have undergone surgery in the last 6 months or have a hip and / or knee prosthesis; uncontrolled hypertension or with blood pressure values higher than 180 mmHg in systolic and diastolic blood pressure at 90 mmHg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-9k66x6	Comparing the use of Everolimus and Tacrolimus reduced dose versus Mycophenolate Sodium and Tacrolimus reduced dose in Liver Transplant patients	Recruiting	Intervention	2018-04-01	<NULL>	<NULL>	1695	Everolimo in combination with Tacrolimus low doses versus Mycophenolate Sodium gastro-resistant coated tablets with low doses of Tacrolimus in Liver Transplant recipients “de novo”	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-14	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-9k66x6	<NULL>	Orthotopic whole organ liver transplant recipients; deceased donor; age above 18 years; both sexes; with graft functionality within 72h of reperfusion.	Patients with pre-transplant protein and urinary creatinine ratio greater than 1mg / g or proteinuria 24h greater than 1g; multiple organ transplant recipients; patients with hypercholesterolemia (greater than 350 mg / dL) or hypertriglyceridemia (greater than 500 mg / dL) severe if use of lipid-lowering therapy with controlled hyperlipidemia will be accepted; previously transplanted liver patients who progressed with graft loss and in need of retransplantation; patients with positive serology for HIV; women who are pregnant, who are planning to become pregnant, are pregnant or breastfeeding, or do not agree to use effective methods of contraception; patients with difficult decision making who are not judged medically or mentally capable of providing informed consent on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-4wg3g3	Implementation Intentions strategy to reduce salt intake among Hypertensive people in Primary Care Clincs	Data analysis completed	Intervention	2018-04-03	<NULL>	<NULL>	1696	Implementation Intentions strategy as a nursing intervention to reduce salt intake among hypertensive patients in primary care practice: evaluation of the effectiveness in real practice	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Enfermagem, Universidade Estadual de Campinas	CAPES, Programa de Doutorado Sanduíche no Exterior	https://ensaiosclinicos.gov.br/rg/RBR-4wg3g3	<NULL>	The inclusion criteria for nurses were: be a registered nurse, emplyer of the municipality; nurses who have been working in the PHCs for at least 6 months. The inclusion criteria for patients were: aged 18 years or over; medical diagnosis of hypertension described in their medical records. The inclusion criteria for social referents were: couples, daughters or sons, parents or pther person responsible for meals preparation for the patient; aged 18 years or over; with availability of attending the health service as patients companion in all phases of the research.	Nurses in long licence of work (more than four months) were excluded. Patients were excluded if they had no verbal conditions of communication; they had mental disorders described in the medical records; there was no possibility of the social referent follow the patient in the nursing consultations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-3fs8ph	Effects of dental bleaching on the satisfaction of patients of different ages	Recruitment completed	Intervention	2018-04-09	<NULL>	<NULL>	1697	Effect of patients’ age on changes of tooth color and esthetic self-perception caused by combined dental bleaching	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Universidade Federal de Uberlândia	FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3fs8ph	<NULL>	It will include patients over 18 years of age up to 25 years and patients aged 40 to 65 years, already selected by the first stage of the research that was dental office bleaching; patients who have never undergone bleaching; non-smoker patients.	Patients who did not complete the first stage of the dental office whitening research will be excluded; patients who refuse to continue bleaching at home; patients who are already satisfied with the color of the teeth post office bleaching.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-5fdjty	Training of respiratory muscles in patients with heart failure	Recruitment completed	Intervention	2018-04-09	<NULL>	<NULL>	1698	Acute effect of inspiratory muscle training on hemodynamic variables in patients with heart failure with reduced ejection fraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-05	Universidade Federal Fluminense - UFF	Universidade Federal Fluminense - UFF	https://ensaiosclinicos.gov.br/rg/RBR-5fdjty	<NULL>	Clinical diagnosis of heart failure; age above 21 years; Doppler echocardiogram with evidence of LV dysfunction LVEF &lt;45% within at least three months; class II and III of the New York Heart Association; stable illness for at least three months; never had or did not undergo treatment with IMT.	Clinical diagnosis of chronic obstructive pulmonary disease; unstable angina; major cardiac arrhythmias; acute myocardial infarction within the last three months; inability to perform the inspiratory exercise session. And also the criteria of exclusion of cardio-bioimpedance; massive pleural effusion; anasarca; moderate or severe aortic regurgitation; patients using intra-aortic balloon; mean blood pressure&gt; 130 mmHg; height &lt;1.20m or&gt; 2.30m; weight &lt;30kg or&gt; 155kg and patients with pacemakers with sensors to adjust heart rate according to respiratory rate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-4ckqq9	The effect of treatment, sex, and severity of knee osteoarthritis on pain, physical function, quality of life and walking	Not yet recruiting	Intervention	2018-04-09	<NULL>	<NULL>	1699	Effect of treatment, level of severity and sex on pain, physical function, quality of life and march in individuals with knee of osteoartrite, having the emotional aspects as variable control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4ckqq9	<NULL>	Diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology; radiological evidence affecting one or more knee compartments, being uni or bilateral; knee pain for at least six months, with a score of three to seven according to the visual analogue scale; age between 50 and 70 years; medical certificate stating that the physical condition is satisfactory; literate	Other musculoskeletal disorders; chronic inflammatory diseases such as autoimmune diseases; diffuse pains; neuromuscular changes; mental illness; relative or absolute contraindications to the execution of the financial year; exacerbation of pain during treatment; irregularity of participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-22rnjh	Effects of strength exercises on postoperative knee rehabilitation	Recruiting	Intervention	2018-04-10	<NULL>	<NULL>	1700	Effectiveness of unilateral resistance training in the postoperative rehabilitation of contralateral ACL	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-31	Universidade Federal de São Paulo / Escola Paulista de Medicina	Instituto de Pesquisa e Ensino do Hospital HOME	https://ensaiosclinicos.gov.br/rg/RBR-22rnjh	<NULL>	Will be included in the study patients of both genders, with different occupations, who practice physical activity at a recreational level, suffered the traumatic injury of the ACL and were submitted to primary reconstruction surgery using contralateral LP grafting (technique in which the graft of the limb opposite the injured). In order for the age group with the highest prevalence of lesions in the ACL (LARSON, 1994) to be respected, in addition to the exclusion of minors, everyone must be aged between 15 and 45 years.	Patients with a history of lesions and / or surgery in the knees prior to or after the injury that generated the clinical picture studied, and those who did not complete all stages of the study, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-65ntbc	Composite Restoration in Permanent Teeth after Selective Removal of Caries	Recruitment completed	Intervention	2018-04-10	<NULL>	<NULL>	1701	Restorative Adhesive Treatment  in Permanent Teeth after Selective Removal of Caries Tissue - A Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-05	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-65ntbc	<NULL>	Patients with absence of uncompensated systemic diseases affecting their caries experience with permanent molars and premolar with deep carious lesions involving the inner half of dentin (Radiographic examination); pulp sensitivity diagnosed by thermal test using refrigerated gas; absence of spontaneous pain history; absence of apical periodontitis checked by periapical radiographs; absence of pain to the vertical and horizontal percussion.	Teeth with cuspal loss; cervical margin of cavity in dentin and cementum; and advanced periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-3vz3nd	Effects of Hatha-Yoga on caregivers of children and adolescents with Cancer	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	1702	Effects of Hatha-Yoga intervention on caregivers of children and adolescents with Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-29	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Hospital Infantil Nossa Senhora da Glória	https://ensaiosclinicos.gov.br/rg/RBR-3vz3nd	<NULL>	Accompanying children and adolescents admitted to HINSG as new cases of cancer; minimum attendance period of 40 weekly hours; absence of prior contact with yoga, meditation or related techniques.	"Volunteers who did not agree to participate in the study or who showed interest were very resistant to being absent from their caregivers, or even if they presented psychic limitation to answer the questions of the initial interview. Cases of hospitalization or deaths in a very short period precluding the invitation to participate in the study; hospitalizations with advanced and irreversible impairment of the patient&apos;s clinical condition, that is, in palliative care; and the cases of prior knowledge of the volunteer about the diagnosis of the assisted.
In the cases of relay of caregivers in care of the same child or adolescent only the participation of a volunteer was allowed, whose choice to participate in the study was based on the above criteria. When caretakers in relay were able to participate in the study a draw was held between them. However, hospitalizations of children or adolescents with many caregivers in relay with uncertainty of a regular return to care were excluded from the study, configuring the non-inclusion of the volunteer during the study period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-2f8xhc	Evaluation of inflammation in patients undergoing to surgery under anesthesia with desflurane or desflurane associated with nitrous oxide	Data analysis completed	Intervention	2016-11-17	<NULL>	<NULL>	1703	Comparison of inflammatory markers in surgical patients under anesthesia with desflurane or desflurane associated with nitrous oxide	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-2f8xhc	<NULL>	Healthy individual;both sexes; aged between 18 and 50 years; who do not present other disease unless the operative condition; undergoing otorhinolaryngologic elective surgery; lasting at least 90 minutes	Smoking; using illicit drugs and alcohol; users of daily vitamin supplements and / or antipyretics; analgesics; antibiotics; anti-inflammatory; among others; the occupationally exposed to paints; fuel; pesticides and hospital environments; those who received radiation ionizing or MRI done in less than 30 days; those who have already undergone chemotherapy or radiotherapy; patients with diseases such as asthma, hypertension; diabetes; cancer; infectious or inflammatory processes; and those who are not referred for surgery of ENT and ophthalmology clinic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-9tn862	Evaluation of consumption of high caloric Infant Formula after surgery of Heart Defects	Recruiting	Intervention	2018-04-11	<NULL>	<NULL>	1704	Evaluation of Energy-enriched Formula consumption on Congenital Heart Disease postoperative	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Hospital da Criança Santo Antônio	Danone LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9tn862	<NULL>	Two years old or less; both genders; undergoing heart surgery	Exclusive breastfeeding; Chylothorax	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-92j6qf	Early mobilization of patients hospitalized in the intensive care unit	Data analysis completed	Intervention	2018-04-11	<NULL>	<NULL>	1705	Early mobilization of critically ill patients - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-92j6qf	<NULL>	Patients with at least 24 hours of admission to the Intensive Care Unit, with or without sedation; older than 18 years old; both genders; presenting significant hemodynamic stability considered as the absence of hypotension or vasopressóricas need for drugs at lower doses less than 1mcg/hora/kg noradrenaline; absence of neuromuscular, oncological, neurological diseases or traumotortopédicas including amputation) prior or recent surgeries; have normal functional ambulation, use of assistive device accepting gait; accepted to participate in the certificate states the responsibility for the patient when they had not been enough awareness for decision making.	Hospitalization prior period with less than thirty days prior to the date of admission to HRTN; Patients transferred from other hospitals to CTI CTI&apos;s HRTN; Patient aware that refused to participate in any of the two groups after randomization; Refusal of the patient to participate in this study after recovering state of consciousness suited to making decisions when your entry is made by authorization of family and / or guardian; Patients who require cardiopulmonary resuscitation during the ICU stay; Patients who had a change in diagnosis as stroke as a cause of ICU stay current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-4w2gd8	Treatment of Oral Opening Limitation in patients with Temporomandibular Joint problems using Laser Therapy	Not yet recruiting	Intervention	2018-04-12	<NULL>	<NULL>	1706	Treatment of Oral Opening Limitation in patients with Temporomandibular Disorder using Laser Therapy: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-4w2gd8	<NULL>	Patients diagnosed with temporomandibular disorder; myofascial pain; mouth opening limitation by the Research Diagnostic Criteria (RDC)	Pregnancy; clinical conditions of muscle spasm; myositis; contracture; polyarthritis; acute traumatic injuries; disc displacement without reduction; total or partial edentulous patients that include the anterior region; treatment with another health professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-6dh6cm	Comparison of two treatments of wounds in the nipples of breastfeeding women	Recruitment completed	Intervention	2012-10-25	<NULL>	<NULL>	1707	Clinical trial for the management of nipple trauma on breastfeeding	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-16	Faculdade de Enfermagem da Universidade Federal de Goiás	GESMAC - Grupo de Estudo em Saúde da Mulher, do Adolescente e da Criança	https://ensaiosclinicos.gov.br/rg/RBR-6dh6cm	<NULL>	Woman in exclusive breastfeeding; have old 18 years or more; having given birth to infants who are able to be breastfed; have a telephone for contact; presenting clinical evidence of detectable macroscopically unilateral or bilateral nipple trauma in the period up to day 10 postpartum.	Health problems that interfere with the healing process; anatomical changes that favor the nipples nipple trauma (inverted nipple, inverted nipple pseudo); residence outside the city of Goiania - GO.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-364qy7	The effect of Antenatal Group about Breastfeeding in Adolescent Mothers	Recruiting	Intervention	2018-04-12	<NULL>	<NULL>	1708	Influence of Antenatal Education of Maternal Breastfeeding in Adolescent: non-randomized clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Faculdade de Medicina da Universidade Estadual de Campinas	Faculdade de Medicina da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-364qy7	<NULL>	Adolescents up to 19 years; primiparous; single gestation; live and term children.	Puerperas with needs for admission to the Intensive Care Unit (ICU) in the immediate postpartum period; Puerperas of newborns with diagnosis of malformation, especially orofacial; Serum positive for human immunodeficiency virus (HIV); Puerperas using drugs incompatible with breastfeeding; Puerperas with diagnosed psychiatric disorder and those with hearing or cognitive impairment that prevent interaction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-7t6nzr	Effects of laser and physical exercise program in patients with knee arthritis	Recruiting	Intervention	2018-04-13	<NULL>	<NULL>	1709	Phototherapy and physical exercise program in patients with knee osteoarthritis: controlled, randomized and triple blinded study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-7t6nzr	<NULL>	Grade II or III of knee osteoarthritis; female subjects; classified as low active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; age between 55 and 70 years; willingness to participate in the treatment plan.	They have cardiovascular, neurological or musculoskeletal disease that makes them unable to perform the exercise protocol; evidence of secondary, inflammatory or metabolic disease; use of conventional, non-conventional or alternative treatments that may potentially have effects on the results of the study (physiotherapy and / or injections of intra-articular corticosteroid or hyaluronic acid during the last 3 months); symptomatic hip OA; absolute contraindication for laser therapy as the presence of neoplasia in the region of lower limbs; individuals who have malnutrition or morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-277fqv	Effects of Video Game Games on Breathing and Balance of Parkinson&apos;s patients	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	1710	Effects of Physical Training with Exergames on the Respiratory Function and on the Balance of Individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-277fqv	<NULL>	Subjects with moderate stages of Parkinson&apos;s disease; both genders; autonomy to perform the exercises; identified through the Mini Mental Status Examination	The smokers; who presented an uncorrected visual deficit; associated respiratory, cardiac or neurological disease; who had changes in Parkinson&apos;s disease medication (dopaminergic) during the study; three consecutive days of physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9r2gpb	Pain evaluation during arterial puncture: use of local anesthetic (EMLA), oral glucose solution and acetaminophen in premature newborns	Recruiting	Intervention	2018-04-13	<NULL>	<NULL>	1711	Pain evaluation during arterial puncture: use of eutectic mixture of local anesthetic (lidocaine and prilocaine), oral glucose solution and acetaminophen (acetaminophen) in premature newborns	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Escola de enfermagem da Universidade Federal de Minas Gerais	Hospital das clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9r2gpb	<NULL>	Gestational age above or equal to thirty weeks and less than thirty-five weeks; weight higher than 1500 grams; being admited in the Neonatal Intensive Care Unit of Hospital das Clínicas of Federal University of Minas Gerais; clinical indication of blood collection trough arterial puncture; newborns in the first two weeks of life; minimum enteral diet of sixty mL/Kg per day; parents or guardians signature on the Informed Consent Form and on the image use authorization term.	Clinical diagnosis of neuromuscular dysfunction;Use of analgesia and / or bolus sedation or continuous infusion in the last 48 hours before the procedure;Newborns born to mothers who use illicit drugs;Diagnosis of necrotizing enterocolitis;Newborns under mechanical ventilation;Presence of skin lesion at puncture sites;Treatment with agents that induce methemoglobinemia such as sulfonamides, acetaminophen, phenobarbital, phenytoin and nitric oxide;Patients with hepatic impairment or bleeding;Patients with hemodynamic instabilityNeed of puncture in different places of the place previously selected for application of topical anesthetic;Need for more than three puncture attempts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4jggg5	Intervention for children with nighttime fears and who do not sleep alone	Data analysis completed	Intervention	2017-01-18	<NULL>	<NULL>	1712	Intervention for preschool children with nighttime fears and avoidance behaviors of sleeping	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-20	Instituto de Psicologia da Universidade de São Paulo	Renatha El Rafihi Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4jggg5	<NULL>	Children aged four to six years; both genders; Who present intense nighttime fears accompanied by avoiding sleep behavior alone or meeting criteria for the diagnosis of separation anxiety disorder or specific phobia of sleeping alone / dark based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V, 2013), or for separation anxiety by the Preschool Anxiety Scale (PAS), or clinic for anxiety subscale by the Children Behavior Checklist  (CBCL-1½ and 5 years).Children who have one or more behavioral problems related to sleep, as follows. Reluctance or inability to go to bed without arguing, crying, complaining, or otherwise delaying bedtime; Reluctance or inability to fall asleep alone without being close to an attachment figure; Reluctance or inability to sleep all night in your own bed without calling your parents or going to bed at night; The problem has occurred for at least six months with an adverse impact on the child and the family, requiring parental intervention for at least two nights a week to comfort the child, impairing the quality of sleep; Availability of at least one parent participating in the intervention program.	Children with neurological impairment, psychotic symptoms or concomitant treatment for nighttime fears; Parents who are not literate or unable to read.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4xqq6n	Physiotherapy in Hemodialysis patients: Effect of Exercise on Physical Ability, Quality of Life and Depression	Data analysis completed	Intervention	2018-04-16	<NULL>	<NULL>	1713	Physiotherapy in Patients with Chronic Renal Failure: Effect of Resistance Exercise on Functional Capacity, Quality of Life and Depression	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4xqq6n	<NULL>	Age between 18 and 60 years; Both sexes; In hemodialysis treatment between 1 and 6 years; Sedentary; Non smoker.	Patients who refuse to sign the informed consent form (EFT); Carriers of hepatitis B and C, HIV and tuberculosis; Patients with a history of myocardial ischemia for less than 6 months; Patients with motor or cognitive deficits that make it difficult to perform the 6MWT, manovacuometry, spirometry, dynamometry and response to KDQOL-SFTM or the BDI scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-7yn9h7	Platform vibration protocol for vaginal muscles	Recruitment completed	Intervention	2016-01-13	<NULL>	<NULL>	1714	Can a full body vibration exercise program increase the strength of female pelvic floor muscles?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-10	Universidade Estadual de Campinas	Universidade Federal de Alfenas (UNIFAL)	https://ensaiosclinicos.gov.br/rg/RBR-7yn9h7	<NULL>	Women aged over 18 years and no complaint of loss of urine.	"Urinary tract infection; Zero Degree of contractility of the PF muscles, according to the Modified Oxford Scale; Presence prolapse grade III or IV; myopathies and diseases recognized modification of collagen;neurological abnormalities; Metabolic diseases (diabetes) or chronic lung; Acute headaches; Herniated disc, disc disease or
spondylolisthesis; Prostheses in the hips and knees; Pacemaker; Recent Deployment pins, plates and scres; tumors; retinal problems;IUD – Intrauterine Device&quot;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-33dfy2	Treatment of wounds with laser and dye	Not yet recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1715	Study of Photodynamic Therapy(PDT) in the healing and repair of ulcerative lesions: literature review and clinical case study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Universidade Federal do Amapá	Fundação Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-33dfy2	<NULL>	"Patients who agree and sign the informed consent form for said disclosure of the case. Patients with known contaminated wounds that need to be treated, whose criteria will be defined by the professional responsible as well as choosing for this therapeutic modality .
Patients older than 18 years."	"Patients with underlying diseases such as diabetes and hypertension.
Patients known to be immunocompromised as oncological under treatment, HIV positive sera, AIDS patients.
Patients who require a systemic medication that is constant or sporadic. In order to evaluate the effect of the therapy first on the repair proposal, it is opted methodologically for its evaluation without intercurrent factors, to
in a later study to associate the local effect of the technique in a specific group of patients, even if there were studies in patients under the conditions of the exclusion criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-7sktsv	Longevity of Ceramic Restorations for posterior teeth.	Recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1716	Longevity of Zirconia singles crowns: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	Faculdade de Odontologia da Universidade Federal de Pelotas	Faculdade Meridional (IMED)	https://ensaiosclinicos.gov.br/rg/RBR-7sktsv	<NULL>	Presence of one or more endodontically treated teeth ou vital-teeth requiring a single crown as final restoration	Teeth with periodontal or endodontic problems, teeth used as abutment of fixed prosthesis and patients with health problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-5n9934	The effect of Atrial Acupuncture and Hydrotherapy on body changes in people with Type 2 Diabetes Mellitus	Recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1717	The effect of Atrial Acupuncture and Aquatic Therapy on systemic and peripheral changes in people with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-5n9934	<NULL>	"Age above 18 years; be a carrier of DM2 with a diagnosis of at least five years; have availability of time for submission to the intervention sessions and who agree to participate in the study by means of the 
Free and Informed Consent Form."	Possess infection; inflammation or injury to the ear patch; make use of piercing, except normal earring; total or partial amputation or presence of lower limb injury; thrombosis in the lower limbs; neurological sequelae.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9329z8	Reduction of Anxiety Symptoms and Promotion of Social and Emotional Skills in Preschool Children	Data analysis completed	Intervention	2018-04-17	<NULL>	<NULL>	1718	Prevention of Anxiety and Promotion of Social-Emotional Skills in preschool children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9329z8	<NULL>	age between 4 and 7 years; both genders; parental permission	Mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9bb2pt	Evaluation of the Efficacy and Safety of a product for health, through the Evaluation of a Dermatologist and Application of Questionnaire	Not yet recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1719	Evaluation of subjective dermatological clinical efficacy and safety with healthcare product appreciability_TCI	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-05	Ipclin - Pesquisa Clínica Integrada	TCI Laboratório Biotecnológico LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-9bb2pt	<NULL>	Age between 18 to 65 years; Female or male; Phototypes I to IV; Subjects susceptible to the appearance of wound and/or contact dermatitis; Able to follow the guidelines and reliable to respect the restrictions of the protocol.	Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn); Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Participants with a history of allergy to the material used in the study; History of atopy; History of conditions aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Renal, cardiac or hepatic transplanted; Intense sun exposure or tanning session up to 15 days prior to initial assessment; Prediction of intense sun exposure or the tanning session during the period of study conduction; Forecast to take a bath, pool or sauna during the study; Participants who practice water sports; Use of the following topical systemic medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection; Treatment with acid vitamin A and / or its derivatives orally or topically up to 01 month before the start of the study; Prediction of vaccination during the study or until 03 weeks before the study; Be participating in another study; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study; History of absence of adherence or unwillingness to adhere to the study protocol; Professionals directly involved in the accomplishment of this protocol and their relatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9m387t	Effect of Exercises and Abdominal Massage compared to Standard Treatment in the Control of Bloating in Women with Irritable Bowel Syndrome	Not yet recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1720	Effect of Kinesiotherapy and Visceral Manipulation compared to Standard Treatment in the Control of Abdominal Distension in Women with Irritable Bowel Syndrome: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9m387t	<NULL>	Women complaining of abdominal distension, aged 18 years or over, diagnosed with Irritable Bowel Syndrome	Acute organic or obstructive gastrointestinal disease, inability to assume the four support position, morbid obesity, psychiatric disorders, alcoholism, psychoactive drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-2kbs8k	Blood pressure response after combination of natural foods and exercise	Data analysis completed	Intervention	2018-04-18	<NULL>	<NULL>	1721	Influence of food and nutritional supplements on exercise-induced hypotension in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-08	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2kbs8k	<NULL>	Hypertensive; sedentary; non-diabetic	Use beta-blockers and calcium channel blockers; Do not participate in at least one of the four experimental procedures; Modify your eating habits during the study period; Do not follow the nutritional recommendations of the days prior to the experimental procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-66gqfs	Effects of Taking Fluids before Surgery in gynecological patients	Recruitment completed	Intervention	2018-04-18	<NULL>	<NULL>	1722	Effects of Preoperative Fasting in gynecological patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66gqfs	<NULL>	women; age between 18 and 70; body mass index less than 40 kg/m2; have a pre-anesthetic evaluation with a classification without surgical risk taking into consideration the classification of the American Association of Anesthesiology.	patients with gastrointestinal, respiratory, C-reactive protein levels greater than 6mg/dL; time of surgery greater than 4 hours, use of steroids for more than 6 months before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4mrftz	Analysis of small and conventional implants in the Maxilla.	Recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1723	Analysis of extra-short and conventional implants in the posterior region of Maxilla.  splint-mounth randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4mrftz	<NULL>	Similar degree of atrophy in bilateral posterior maxilla region with a minimum subantral bone height of 4.0 mm and a width of 6.0 mm.	"General contraindications to surgeries with dental implants; Patient submitted to irradiation in head and neck region; Patients immunosuppressive and immunosuppression; Treated or being treated with anti-resorptive medicinal products or alter bone metabolism; Untreated periodontitis; Poor oral and low hygiene motivation; Pregnancy or Infant; Diabetes uncontrolled; Psychiatric problems or
unrealistic expectations regarding treatment; Substance abuse; Lack of dentition opposite the area intended to receive the implants; Extraction sites (Less than 3 months after extraction); Smoking."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-2685h6	Evaluation of the Preventive Effect of Pain by the Use of Melatonin During Female Sterilization Surgery	Not yet recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1724	Evaluation of Melatonin Analgesic Effects Used in the Perioperative Period of Bilateral Tubal Ligation: Randomized Clinical Trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Hospital Municipal Pedro I	https://ensaiosclinicos.gov.br/rg/RBR-2685h6	<NULL>	Women scheduled for bilateral tubal ligation; age between 18 and 65 years.	Pregnant patients; history of intolerance or chronic use of opioids or other medications proposed in the study; chronic use or known melatonin intolerance; addicted to alcohol or drugs; use of analgesics, opioids or not, within 24 hours prior to the procedure; inability to provide informed consent and low easily identifiable cognition; patients who present contraindication to neuroaxis blockade.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9rh8vr	Impacts of neurosurgery on non-motor symptoms in Parkinson&apos;s Disease patients.	Data analysis completed	Observational	2018-04-18	<NULL>	<NULL>	1725	Impacts of staged bilateral pallidotomy or campotomy on non-motor symptoms in Parkinson&apos;s disease.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-11-01	Hospital Santa Marcelina	Hospital Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-9rh8vr	<NULL>	"Patients with Idiopathic Parkinson&apos;s Disease; clinical Indication for neurosurgical treatment for Parkinson&apos;s disease; 
Age greater than 18 Years; 
Stage two or greater on Hoehn and Yahr Scale in the absence of medication.  
Presence of significant motor dysfunction during three or more hours per day despite receiving adequate drug treatment; 
Persistence of motor dysfunction under revised and adequated medication regimen for at least 1 month; 
Consent to participate in the defined evaluations; Consent to perform surgical procedure with the purpose of treating Parkinson&apos;s symptoms; 
Patients who sign the Informed Consent Form according to the Norms of the Research Ethics Committee of Santa Marcelina Hospital."	"Patients with parkinsonism associated with another degenerative disease such as Multi-systemic Atrophy; Dementia by Lewy Bodies; Alzheimer&apos;s disease; Cortico-Basal degeneration; Fronto-temporal dementia; cerebellar ataxia. Patients with suspected secondary parkinsonism such as cerebral vascular disease; Use of medications; Normal pressure hydrocephalus; Traumatic brain injury. Patients with previous surgical treatment for Parkinson&apos;s Disease as pallidotomy; talamotomy or electrode Implant for deep brain stimulation. Patients with clinical or cardiologic contraindications to perform the surgical procedure. Current use of neuroleptic drugs for the treatment of behavior disorders or hallucinations associated with the use of dopaminergic drugs. Patients with schooling Level very Low (below 2 Years) or with auditory or visual deficiency, in such a way as to Inviabilize neuropsychological evaluation. Personal history of alcohol abuse.
Diagnosis of current severe depression, according to DSM-IV criteria - American Psychiatric Association 2000. Patients with dementia diagnosis associated with Parkinson&apos;s disease according to the criteria stablished by the movement disorders society."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4x7dny	The effectiveness of Happy Child Program on child development	Not yet recruiting	Intervention	2018-04-19	<NULL>	<NULL>	1726	Impact Evaluation of the Happy Child Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pelotas	Ministério do Desenvolvimento Social e Agrário	https://ensaiosclinicos.gov.br/rg/RBR-4x7dny	<NULL>	Children under six year old.	Families whose parents / guardians are under the age of 18 living alone; families in which the target child of the program was born twin; children with physical or cognitive disabilities reported by those responsible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-6yfcbm	Red and Orange Light to Treat Wrinkles	Not yet recruiting	Intervention	2017-07-19	<NULL>	<NULL>	1727	Efficacy of Phototherapy with Red and Amber LEDs for treatment of Facial Aging	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6yfcbm	<NULL>	Women will be included; 40-65 years old; with skin phototypes II, III and IV on the Fitzpatrick scale and signs of aging III and IV in Glogau scale.	Will be excluded from the study male patients; women under the age of 40 and over 65; with thyroid changes (hyperthyroidism or hypothyroidism) and who are not taking the treatment or taking the medication for less than 1 year; who have received facial fillers in the last 12 months; who are performing some facial aesthetic procedure; that they are taking retinoic acid or any vitamin A derivative (tretinoin or isotretinoin, topical or oral); who are using cosmetics or medications that may increase skin photosensitivity; that they present some skin pathology, such as acne, psoriasis, vitiligo, etc .; who presents big laterality of skin aging; professional drivers; who have undergone bariatric surgery or who are under strict diet; that they are making use of some type of supplement (topic or oral) for improvement of the skin conditions; in the period of pregnancy and / or lactation; patients who are not assiduous in the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-5c3x6z	The use of Swiss Ball and the acceleration of labour: a randomized study	Recruiting	Intervention	2018-04-20	<NULL>	<NULL>	1728	The use of Swiss Ball and the duration of labour active face:  a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5c3x6z	<NULL>	"Be primiparous, meaning that is giving birth for the first time and who choose natural labour (vaginal route), which will be allocated in an experimental or control group according to randomization;
Be secundiparous, meaning that is giving birth for the second time vaginally, having their first birth being vaginal also, to be allocated in an experimental or control group according to randomization;
Being in the active phase of labour, meaning two to three efficient uterine contractions in the minutes and cervical dilatation of 4 cm;
Bag of waters with integrity;
Gestational age between 37 to 41 weeks and six days, calculated by last menstrual period and / or the result of early ultrasound (up to 20 weeks);
Gestation with a single fetus alive in cephalic presentation. Fetal position will not be initially evaluated in this study, therefore, at the 4 cm of dilation is not possible to determine if the fetus is flexed or deflected."	It will be excluded women that present: caesarean section indication at admission; clinical or obstetric complications to justify performing the caesarean section; parturient with fetal without vitality;  women that in vaginal touch, during the subsequent evaluations, deflected fetal position; Use of uterotonic drugs; use of analgesia during labour and referral to another hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-7564fd	Effect of the meditation on weight loss, on psychological stress and eating behaviors modifications in women with excess weight	Recruitment completed	Intervention	2018-04-23	<NULL>	<NULL>	1729	Effect of the Healing meditation on weight loss, on stress and on the eating behavior in overweight and obese women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Escola Bahiana de Medicina e Saúde Pública - EBMSP	Escola Bahiana de Medicina e Saúde Pública - EBMSP	https://ensaiosclinicos.gov.br/rg/RBR-7564fd	<NULL>	Be over 18 years old; to be in a weight loss program at the CCVP or at ADAB; to be overweight or obese; to be literate	Women with diagnosis of psychosis or borderline; using weight loss medications; to be pregnant or having had a delivery in less than 1 year; not to accept to take part in the study; not to sign the Term of Free and Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4w9pkt	Number of academy gymnasts suffering from overtraining syndrome in the city of Joao Pessoa	Data analysis completed	Observational	2018-04-24	<NULL>	<NULL>	1730	Prevalence of overreaching and overtraining in gymnastics teachers of the city of João Pessoa	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-12-17	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4w9pkt	<NULL>	Have been giving gym classes for at least two years; ministering and practicing at least 15 lessons per week; at least six months since the last vacation; seemingly healthy and free of muscle-tendon injuries in the last 30 days	Have some type of injury that affects your locomotion; have some type of chronic-degenerative disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-55smwr	Evaluation and treatment of pain in the shoulder after Stroke by game ShoulderForce	Recruiting	Intervention	2016-09-29	<NULL>	<NULL>	1731	Evaluation and treatment of Painful Shoulder Syndrome after Stroke by exergame ShoulderForce	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-22	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-55smwr	<NULL>	Individuals diagnosed with stroke in chronic phase; both genders; aged between 40 and 80; presenting the painful shoulder syndrome; spasticity less than two in Ashworth scale; voluntary movement of flexion and abduction	Individuals in the acute phase; displaying a neurological pathologies associated and / or other painful shoulder condition that is not related to post-stroke event; spasticity greater than two of Ashoworth scale; cognitive changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-5yk6cn	Intervention for children with developmental coordination disorder	Recruitment completed	Intervention	2018-04-24	<NULL>	<NULL>	1732	Long-term effects of task-oriented intervention in the motor competence of children with DCD: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-08	Universidade Federal de Pernambuco	Ilana Santos de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-5yk6cn	<NULL>	have between 7 and 10 years old; be volunteer to participate in research; have the Free and Informed Consent form signed by parents or guardians; motor score below the 15th percentile at MABC-2; have no diagnosis of neurological or physiological problem that prevents the tests	present a diagnosis of learning difficulties or any behavior problems or orthopedics; does not perform the tests in the pre or post-intervention; does not attend three days of practice (intervention or school physical education classes) consecutive or four alternate days; and to abstain from the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4rw55d	Clinical Evaluation of Adhesives for Restoration of cavities in the Cervix of the Teeth not Caused by Caries	Data analysis completed	Intervention	2018-04-27	<NULL>	<NULL>	1733	Randomized Clinical Evaluation of Simplified Adhesive Systems in Non-Carious Cervical Lesions: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-10	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4rw55d	<NULL>	"Being in good general health; Be over 18 years of age; Have an acceptable level of oral hygiene; To present at least 20 teeth under occlusion; To have at least 4 non-carious lesions on different teeth to be restored.
The lesions should be non-carious, non-retentive, with a depth greater than 1mm, and enamel and dentin envelopment of vital teeth without mobility; The cavo-superficial margin can not involve 50% more enamel."	Patients with extremely poor oral hygiene; Cronic or severe periodontitis; Severe parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-2fjqvn	Evaluation of the incidence of facial nerve dysfunction after surgeries of benign parotid gland tumors performed with or without facial nerve monitoring using continuous electromyography during surgery	Recruiting	Intervention	2018-04-27	<NULL>	<NULL>	1734	Intraoperative facial nerve monitoring during superficial parotidectomy for benign parotid neoplasms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Faculdade de Ciências Médicas da Unversidade Estadual de Campinas	Faculdade de Ciências Médicas da Unversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2fjqvn	<NULL>	Adult patients with parotid neoplasms treated with superficial parotidectomy	"Neoplasms located in the deep lobe of the parotid
Malignant neoplasms requiring total parotidectomy
Previous parotid surgery
Facial nerve dysfunction prior to the surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8r6xtc	Martial Arts Training combined with Multidisciplinary Interventions in Overweight and Obese adolescents	Recruiting	Intervention	2018-04-28	<NULL>	<NULL>	1735	Effect of Martial Arts Training using Karate Strokes combined with Multidisciplinary Interventions in Overweight and Obese adolescents: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-07	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8r6xtc	<NULL>	Adolescents of both sexes; with ages between 12 years and 18 years incomplete; who have the capacity to understand the questionnaires; to sign the Terms of Free and Informed Consent; that they deliver the Term of Free and Informed Consent signed by the legal representatives; who are in pubertal stage three, four or five; which has a BMI greater than one standard deviation above the median BMI according to the WHO growth reference table for each age; who has not performed regular physical exercises in the last 3 months that will precede the start of the research; who have the physical conditions to perform regular physical exercises; who is willing to attend interventions; who has never had drug treatment for weight loss; that does not make chronic use of alcohol.	Adolescents with a history of alcohol or drug abuse; who have diseases that limit exercise or put their physical integrity at risk, such as cardiovascular diseases, osteoarticular diseases, type I diabetes, renal failure, endocrine diseases and metabolic complications such as hyperinsulinemia and hypercholesterolemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4sty47	The influence that physical exercise Tai-Geiko provides in people with multiple sclerosis regarding muscle strength, balance and performing two tasks at the same time.	Data analysis completed	Intervention	2018-04-29	<NULL>	<NULL>	1736	The influence of Tai-Geiko on the physical and functional aspects of patients/peoples  with multiple sclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-13	Faculdade de Educação Física da Universidade Federal de Mato Grosso	Faculdade de Educação Física da Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4sty47	<NULL>	"Medical diagnosis of multiple sclerosis for two years;
Undergoing treatment with medical follow-up;
Obtain Expanded Disability Status Scale EDSS score of less than 6.0;
Do not have medical diagnosis of diseases secondary to Multiple Sclerosis as: physical and / or mental deficiencies; heart diseases; Dyslipidemias; And Diabetes Mellitus;"	"Not being in medical follow-up
Failing to perform the physical tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8r4jpg	Effects of protein supplementation in nutritional status of hemodialysis patients	Data analysis completed	Intervention	2018-04-29	<NULL>	<NULL>	1737	Effects of oral supplementation with albumin in nutritional status of hemodialysis patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Nutrição da Universidade Federal de Goiás	Centro de Nefrologia - Centrel	https://ensaiosclinicos.gov.br/rg/RBR-8r4jpg	<NULL>	The inclusion criteria adopted for participation in the study were: patients of both sexes, aged between 20 and 79 years, for at least three months on hemodialysis treatment, performing three sessions per week.	The exclusion criteria were: bedridden patients; Amputees; Patients with decompensated diabetes; Pregnant women; Who are consuming nutritional supplements containing protein; Food intolerance or allergy to egg white protein; Liver disease, intestinal malabsorption, cancer and Acquired Immunodeficiency Syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-35h4xg	Female pelvic floor muscle training in the urinary symptoms of Urinary Incontinence	Recruiting	Intervention	2018-04-30	<NULL>	<NULL>	1738	Female pelvic floor muscle training in the urinary symptoms of Stress Urinary Incontinence and Mixed Urinary Incontinence	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35h4xg	<NULL>	Women aged 18 years old and older with symptoms of stress urinary incontinence or mixed urinary incontinence identified by the following investigation: non-zero scores for the International Consultation on Incontinence Questionnaire Overactive Bladder, validated in Portuguese language by Pereira et al., (2010); positive response to one or more of the bold options referring to question 6 of the validated questionnaire for the Portuguese language: International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form (ICIQ-UI SF), validated in Portuguese language by Tamanini et al., (2004)	Women with &quot;Pure&quot; Hyperactive Bladder Syndrome and do not present symptoms of associated stress urinary incontinence; women who have never had sexual intercourse because of the impossibility of participating in the pelvic floor muscles evaluation; those with no contractility of the pelvic floor muscles identified by vaginal palpation (grade zero, according to the Oxford Modified Scale); those with urogenital prolapse equal to or greater than three and apical prolapse (uterus or vaginal dome), assessed by Pelvic Organ Prolapse Quantification (POP-Q); those with Body Mass Index (BMI)&gt; 30, due to interference caused by body fat in the electromyography exam; carriers of myopathies and diseases with recognized alteration of collagen; carriers of neurological abnormalities, cognitive disorders, physical limitations that preclude participation in the study; those who perform or have already performed physiotherapeutic and / or surgical interventions for the treatment of pelvic floor dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4vt6th	Evaluation of a Molecular Test for the rapid detection of of microorganisms in patients with Generalized Infection (Sepsis)	Not yet recruiting	Observational	2018-04-30	<NULL>	<NULL>	1739	Evaluation of a Molecular Method for the rapid detection of pathogens in patients with Sepsis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4vt6th	<NULL>	Patients with suspicion of sepsis that required hospitalization in an intensive care unit	"Pregnant patients;
Patients younger than 18 years.
Dying patients, in palliative care or with an expectation of ICU stay less than 24 hours."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-7pdc8y	The impact of two Models of Aerobic Training on Cognitive View, Body Composition and Metabolism of Young People with Obesity	Recruitment completed	Intervention	2018-04-30	<NULL>	<NULL>	1740	The impact of two Models of Aerobic Training on Cognitive Function, Morphological and Systemic Immunomotabolic Changes of Young People with Obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Ciências e Tecnologia - UNESP / Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-7pdc8y	<NULL>	Men; age between eighteen and thirthy five years old; BMI higher then  twenty and seven kilogramas by meters squared; high-school completed; no medicine in use; no smokers.	Uncommon angina, recent cardiac infarction less then four weeks, decompensated heart failure, severe valve disease, uncontrolled arterial hypertension, renal failure, diabetes, orthopedic and or neurological limitations, cardiomyopathy, presence of planned surgeries during the study period, depression, participation in another study and alcohol or drug abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-4mrrhh	Evaluation of the effectiveness of Different Medications in the Resolution of channel inflammations	Recruitment completed	Intervention	2018-04-30	<NULL>	<NULL>	1741	Clinical Evaluation of Different Intracanal Medications on the Periapical Levels of Resolvins and Lipoxin - New Endodontic Perspectives	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-12	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mrrhh	<NULL>	"Patients in adulthood;
Need for endodontic treatment;
Permanent teeth with primary endodontic infection;
Unirradicular;
Presence of a single canal and periapical lesion;
Absence of periodontal pockets greater than 4 mm;
No mobility."	"Teeth that can not be insulated with the rubber dam;
With root fracture;
Exposure of the pulp chamber;
Patients who have used antibiotics or antifungals in the last 3 months;
Patients with systemic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-53fx6p	Effects of Physical Exercise on Cognitive and Motor Functions in Alzheimer&apos;s Disease	Data analysis completed	Intervention	2018-04-30	<NULL>	<NULL>	1742	Exercise, Biomarkers and Functionality in Alzheimer&apos;s Disease and in Frailty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-03	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-53fx6p	<NULL>	Elderly with clinical diagnosis of Alzheimer&apos;s disease, according to the Diagnostic and Statistical Manual of Mental Disorders; Severity of mild and moderate dementia according to the Dementia Clinical Assessment Score; Availability for participation of the evaluations proposed by the researcher; Elderly persons and their respective caregivers who agree to the study procedures and who agree to sign the Informed Consent Form.	"Elderly patients with coronary heart disease, cardiac arrhythmias, uncontrolled hypertension and angina symptoms, or who have any absolute restriction on physical exercise; Elderly people with visual, auditory, dizzying or other impairments that impair locomotion and balance;
Elderly with other neuropsychiatric conditions;
Frequency less than 70% in the program."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-8jpw57	Evaluation of nutritional and clinical parameters associated with Mortality in patients at pediatric ICU: MaSCI-kids study	Recruiting	Observational	2018-04-30	<NULL>	<NULL>	1743	"Evaluation of nutritional and clinical parameters predictive of Mortality in critically ill children: multicenter cohort study MaSCI-kids (malnutrition risk
screening for critically ill kids)"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8jpw57	<NULL>	Children and adolescents of both sexes; Aged between one month and 17 years of age; Were admitted to the participating PICUs for a maximum of 72 hours.	Children and adolescents who progress with discharge or death during the first 72 hours of hospitalization; Who are in palliative care or are participating in a nutritional intervention study; Readmissions in the PICU; And premature infants who are less than one month old at the time of admission, after calculation of the corrected age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6k9rgc	Laser Therapy on Pain Intensity of patients with advanced knee Osteoarthritis	Not yet recruiting	Intervention	2018-05-01	<NULL>	<NULL>	1744	Photobiomodulation on Pain Intensity of patients with Grade 4 of Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6k9rgc	<NULL>	Age between 55-85 years old; diagnosed with knee osteoarthritis (unilateral or bilateral) for at least 2 years; have pain in at least 3 of the following actions: go up and down at stairs, kneeling, sit and stand up, running, and standing up for at least 2 minutes; more than 4 points (moderate) at numeric rating scale; and have grade 4 at Kellgren-Lawrence grading system.	Uncontrolled diabetes mellitus; not treated arterial hypertension; neurological deficit (motor or sensory); diagnosed with cancer; fibromyalgia; previous injection of hialuronic acid (and/or invasive therapies); or refusing to  participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-57gtfg	Evaluation of the use of nasal cannula after the correction surgery of facial discrepancies: passage of air and patient&apos;s discomfort	Recruiting	Intervention	2018-05-01	<NULL>	<NULL>	1745	Evaluation of the Nasal Cannula after Orthognathic Surgery: Nasal Airway Permeability and Patient Discomfort	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-20	Hospital de Reabilitação de Anomalias Craniofaciais	Hospital de Reabilitação de Anomalias Craniofaciais	https://ensaiosclinicos.gov.br/rg/RBR-57gtfg	<NULL>	"In this study, 30 patients with repaired cleft palate and / or lip submitted to orthognathic surgery with Le Fort I type osteotomy and bilateral mandibular sagittal osteotomy performed by a single mandibular maxillofacial surgeon from the Hospital for the Rehabilitation of Anomalies Craniofacial of the University of São Paulo (HRAC / USP) of Bauru-SP.
Age between 18 and 45 years."	"Present cognitive deficit according to medical records;
To present important intraoperative events in the intraoperative period and the first 24 postoperative hours, such as:
Bleeding;
Duration of surgery beyond 3 hours;
Unwanted jaw fracture;
Airway of difficult intubation (malampat 4, short neck, severe jaw deficiency, deficiency in cervical extension and difficulty in visual access of epiglottis in intubation);
Selective intubation;
Pulmonary problems due to intubation (pulmonary auscultation suggestive of atelectasis and barotraumas)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-74qm3m	Clinical investigation of a photography-aided behavioral intervention to reduce risk factors for caries and malocclusion (bad bite&quot; in high-risk infants	Recruitment completed	Intervention	2018-05-01	<NULL>	<NULL>	1746	Role of the Dental Surgeon in a Neonatology Service in a Public Maternity Hospital in Goiânia-GO	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Hospital Maternidade Dona Iris	Hospital Maternidade Dona Iris	https://ensaiosclinicos.gov.br/rg/RBR-74qm3m	<NULL>	Mothers of healthy children born from August 1st to 31th, 2015.	Low gestational age at birth (defined as younger than 37 weeks of gestation). Low birth weight (defined as children born weighing less than 2,500 grams). Suspected congenital malformations. Any infectious disease. Twin pregnancies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9d48pk	Evaluation of TCD-10023 stent in patients with acute myocardial infarction. MASTER study T120E4	Data analysis completed	Intervention	2015-03-17	<NULL>	<NULL>	1747	Safety and efficacy of TCD-10023 drug-eluting stent in management of patients with acute ST-elevation myocardial infarction. MASTER study T120E4	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-15	Instituto Dante Pazzanese de Cardiologia	Real e Benemérita Associação Portuguesa de Beneficência	https://ensaiosclinicos.gov.br/rg/RBR-9d48pk	<NULL>	Age equal or more than 18 years; Chest pain &gt; 20 minutes; Primary PCI &lt;24h from symptoms onset; ST-segment elevation of &gt; 1 mm in &gt; 2 contiguous leads, or (presumably new) left bundle branch block, or true posterior MI with ST depression of &gt; 1 mm in &gt; 2 contiguous anterior leads; Presence of at least one acute infarct artery target vessel with one or more coronary artery stenoses in a native coronary artery from 2.5-4.0 mm in diameter that can be covered with one or multiple stents; Signed informed consent	Female of childbearing potential (age &lt; 50 and last menstruation within the last 12 months), who did not underwent tubal ligation, ovariectomy or hysterectomy; Known intolerance to aspirin, clopidogrel, heparin, bivalirudin, cobalt, chromium, nickel, sirolimus or contrast material; Currently participating in another trial before reaching primary endpoint; Mechanical complication of acute myocardial infarction (e.g. cardiogenic shock…); Acute myocardial infarction secondary to stent thrombosis; Previously stented infarction related artery (IRA); Planned surgery within 6 months of PCI unless dual antiplatelet therapy is maintained throughout the peri-surgical period; Patients with non-cardiac comorbid conditions with life expectancy &lt; 1 year or that may result in protocol non-compliance; History of bleeding diathesis or known coagulopathy; Use of oral anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-73c67m	Effects of a physical training with video game and food supplementation with protein on muscle mass and balance in pre-frail older people	Recruiting	Intervention	2017-01-02	<NULL>	<NULL>	1748	Effects of physical training program with virtual games and protein supplementation (WiiProtein) on musculoskeletal function and the risk of falls in pre-frail older people.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-73c67m	<NULL>	Both sexes; aged 65 years or over; to present itself as pre-fragile; not presenting with an acute disease or terminal illness; no metabolic instability or decompensated cardiovascular disease; do not present untreated thyroid disease; not having type I diabetes; be carriers of controlled type II diabetes, provided they present values ??of glycated hemoglobin between 8-9%; do not use medications that may affect muscle metabolism such as corticosteroids and hormones; not making use of nutritional supplement (caloric-protein); present adequate renal function (GFR&gt;60mL/min); did not present cognitive alterations according to the Mini Mental State Examination; do not present significant cognitive disturbances (vision/hearing) that prevent the understanding/execution of the evaluations and protocol of proposed exercises; to have independent gait for an 8-meter flat course, with or without assisted equipment; and functionality in the lower limbs evaluated by the Lequesne Algofunctional Questionnaire for the hip and knee joint with a score of less than or equal to 7 points for each joint separately by the Foot and Ankle Outcome Questionnaire - FAOS score above 75 points; not presenting neurological and/or orthopedic diseases with fixation or prostheses with metallic or non-metallic implants that prevent the performance of the evaluations and/or exercises proposed; osteoporosis with no history of previous fractures; the patient was not suffering from severe deficiencies diagnosed and described in the chart: cardiac, respiratory, hepatic and decompensated arterial hypertension. Have no previous history of fractures in the lower limbs and spine that prevents the full realization of the evaluations and exercises proposed for this study; not to use drugs that affect the balance; do not present any type of intolerance/allergy to milk protein; no visual impairment assessed by the Snellen card, and if participants exhibit borderline visual acuity (e.g.: one eye with 20/70 and the other presenting a single error reading the same line), it will be considered as a visual impairment, and it is considered acceptable to include in the study, in the case of presenting some visual function deficiency, to use the correction through the use of glasses or lenses	Elderly who report pain in any body region or other region that limits the evaluation and/or execution of physical training exercises; With diagnosis of neurological and/or orthopedic diseases with fixation or prosthesis with metallic or nonmetallic implants, cardiac, respiratory, renal, hepatic, diabetes, endocrine and decompensated hypertension; and elderly people not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6r7ww5	Effect of muscle endurance training in elementary public school teachers	Data analysis completed	Intervention	2012-02-29	<NULL>	<NULL>	1749	The chronic effect of stretching taken before or after exercise for hamstrings on musculoskeletal symptoms in a group of public school teachers of Matinhos-PR	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-25	Universidade Federal do Paraná Setor Litoral	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6r7ww5	<NULL>	"Effective municipal elementary school teachers, working in classrooms, directly with the students;
General health condition;
Sedentarysm for at least eight weeks."	"Teachers retired; 
Current pathology or early that prevented evaluations and/or exercises; 
Participated in other programs that included physical exercises and evaluations that were incomplete data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-44g8vn	Comparison of the effect of Cicloergometro and physiotherapeutic exercises in patients with Chronic Renal Disease under treatment	Recruiting	Intervention	2018-05-03	<NULL>	<NULL>	1750	Comparison of the effect of Cicloergometry and Conventional Physiotherapy in patients with Chronic Renal Disease in Dialytic Treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-12	Universidade Federal de Alfenas UNIFAL-MG	Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro	https://ensaiosclinicos.gov.br/rg/RBR-44g8vn	<NULL>	"Inclusion criteria: both genders; individuals within the age group
20 to 70 years; patients from the Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro, Hemodialysis (HD) sector, submitted to HD three times a week."	Exclusion criteria: hemodynamic instability; pathological fractures; cognitive deficit or incoordination to run the apparatus used; Diabetes Mellitus and Systemic Arterial Hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9c4jxp	Proposal of treatment systematization for Benign Bone Tumors comparing different techniques in different forms of presentation	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1751	Systematization proposal for the treatment of Bone Defects created after Curettage of Benign Bone Tumors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-24	Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão	https://ensaiosclinicos.gov.br/rg/RBR-9c4jxp	<NULL>	Patients of any age and sex will be included; with benign bone tumors B2 and B3 according to the classification of Enneking; located in the long bones of upper or lower limbs and that require surgical treatment by curettage. Curettage indication consists of impending fracture; pain and size increase or progression of the lesion.	Patients with complete pathological fracture with deviation; multiple lesions that compromise the patient&apos;s function; systemic bone diseases; metadiaphyseal defects accessed through small windows smaller than 1/8 of the perimeter; proximal femur metadiaphyseal lesions with medial cortex (calcar) discontinuity in less than 30 years old patients or who refuses to participate in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-77sbfp	Clinical evaluation and digital monitoring of patients submitted to Home Dental Bleaching	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1752	Randomized clinical evaluation and digital Monitoring of patients submitted to Home Dental Bleaching: Effect of wear-time of dental bleaching on the degrees of Collaboration and patient Catisfaction, on the Effectiveness and occurrence of Sensitivity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-31	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-77sbfp	<NULL>	Absence of caries injury; Absence of defective or fractured restorations; Absence of periodontal diseases; Good systemic condition; Healthy oral soft tissues; No historical adverse reaction station to peroxides; teeth with a minimum of A2; Absence of dental elements with spontaneous pain; Absence of non-carious cervical lesions and of dentinal tissue exposed in the incisal regions.	Restorations in the vestibular of the central, lateral and canine incisors; Teeth with orthodontic appliances fixed or containing resinous residues after their removal; Pregnant or breastfeeding; Smokers and Patients who routinely use alcohol; Have previously had bleaching treatment; Teeth with fluorosis enamel stains and without pulp;  Patients with bruxism habits and those who experienced dental sensitivity prior to the experiment; Did not accept the search consent form; Unavailability of time and commitment to research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9mgk2x	Respiratory exercise prescription by time or repetitions in respiratory disorders.	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1753	Is there difference in heart and respiratory variables to prescribe respiratory exercise by repetition or time-controlled  in respiratory disorders?	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-02	Universidade do Sagrado Coração	Fundação para o desenvolvimento médico hospitalar	https://ensaiosclinicos.gov.br/rg/RBR-9mgk2x	<NULL>	Time for the participation of the proposed protocol; over 18 years-old; patients with stable pneumopathies; no hospitalization in the last month; understanding and ability to perform tests and respiratory techniques.	acute myocardial infarction; vertigo; high ocular pressure; cardiac pacemaker; tympanic perforation; pregnant women; hemodynamic instability; thoracic drain wearer; absence in the second evaluation; intense physical exercise for more than three times for week; continuous physiotherapeutic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6bdmsk	Encourage the practice of Physical Activity in patients after stroke via a Program of Physical Exercises performed in the community: a feasibility study	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1754	Promoting Physical Activity in survivors Stroke via Self-management: a randomized control trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6bdmsk	<NULL>	"Individuals suffered a stroke and were discharged from an acute stroke unit;
over 18 years old; be able to walk independently with velocity greater than or equal 0.8 meter per second; absence of cognitive identified by the Mini Mental State Examination."	Individuals with aphasia or other neurological condition not correlated with stoke; unstable cardiovascular condition or unstable medical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-78s6nh	Influence of a catechin from green tea incorporated in the adhesive system on the clinical performance of adhesive restorations	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1755	Influence of the catechin incorporation in an universal adhesive system: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal do Ceara	Universidade Federal do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-78s6nh	<NULL>	"Be over 18 years old;
To present adequate oral hygiene condition and absence of periodontal disease;
Have at least 20 teeth in occlusion;
To present at least four teeth with non-carious cervical lesions (erosion, abrasion and / or abfraction) under occlusion."	"To present bruxism;
To present lesions previously restored;
Introduce premature contacts;
Have prostheses (fixed or
removable) surrounding the teeth with LCNC."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-72dsyv	Nursing care planned with a computer program for the comfort of people with cardiovascular diseases	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	1756	Computerization of the nursing process: a technology for the clinical care of the comfort of people with cardiovascular disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-04	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-72dsyv	<NULL>	Age equal to or greater than 18 years; medical diagnosis of cardiovascular disease; accompanied in the home modality	Difficulty in speech; cognitive deficit that hinder communication; reside in an area of extreme urban violence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6tjmw3	An Electronic Program to help people decide if they want to quit smoking	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1757	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Amparo a Pesquisa do Estado de Minas Gerais	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-6tjmw3	<NULL>	Adult smokers undergoing treatment State Center for Specialized Attention of Juiz de Fora and who sign the free and informed consent form.	Smoker users who, at any time, request the cancellation of the signed free informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9nh9m4	Effect of laser on the pain of women with nipple damage	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1758	An Influence of 2 joules of the Red Laser in the control of the Pain of puerperas with nipple Damage in breastfeeding: a double blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Federal de São Paulo	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-9nh9m4	<NULL>	Women; postpartum period; in the maternity hospital; with nipple damage; exclusively breastfed; with a single child born at term and weighing two thousand and five hundred grams or more.	Malformed nipples; mastitis; malignant disease; use of any topical substance in the nipple; photosensitivity or any adverse reactions to exposure to sunlight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-84hbf5	Comparing the effect of Ibuprofen use and laser therapy on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1759	Comparison of the effect of the use of Ibuprofen and the Photobiomodulation therapy on the postoperative pain in Endodontics: a controlled and randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-84hbf5	<NULL>	adult patients who already have indications for endodontic treatment in lower molar permanent teeth; Diagnosed with irreversible pulpitis; Have a contact phone number	Pregnant patients; Use of analgesic medication before treatment; Immunocompromised patients; Hypersensitivity to anti-inflammatories; Teeth with endodontic complications; Teeth unable to be treated in a single session; Patients unable to receive a call	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-69ynnw	Effect of acupuncture with needles on the physical and psychological and emotional aspects of patients with problems in the articulation of the jaw.	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1760	Effect of Auriculotherapy on the physical and psycho-emotional aspects of patients with myofascial temporomandibular disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-04	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-69ynnw	<NULL>	Adult volunteers aged 18 years or over; score equal to or greater than 3 in the Triage Questionnaire of the American Academy of Orofacial Pain; with the presence of myofascial pain according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD).	Volunteers with non-painful temporomandibular disorder according to RDC / TMD; patients with associated diseases: fibromyalgia, facial paralysis, rheumatoid arthritis, mental illness or cognitive deficits that would impede the understanding of some of the stages of the research; pregnant women; with external ear injuries or with immunodepression; carriers of clotting disorders, metabolic, vascular or neoplastic diseases; volunteers submitted to other types of associated therapies - interocclusal apparatus, psychotherapy, physiotherapy, orthodontics, alternative therapies; volunteers who use continuous medication (analgesics, anti-inflammatories, muscle relaxants, antidepressants / anxiolytics, anticonvulsants).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-43gmqn	Evaluation of the effects of protein supplementation on postmeal plasma glucose in adults with type 1 diabetes mellitus	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1761	Evaluation of the effects of supplementation of protein module in late prandial glycemia in adults with Diabetes Mellitus type 1	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43gmqn	<NULL>	Patients with Diabetes mellitus type 1, according to the diagnostic criteria presented by the Guideline of the Brazilian Society of Diabetes, of both sexes; with ages ranging from 18 to 60 years; Body mass index (BMI) within the eutrophic and overweight parameters (between 18.5 kg / m² and 30 kg / m²), according to World Health Organization (WHO) classification criteria and that agree to the Free and Clarified Consent.	Patients with a glycosylated hemoglobin (HBA1C) test of the last 3 months greater than 9%; pregnant women; patients diagnosed with renal, hepatic and or thyroid pathologies and microalbuminuria present.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9t4xxk	Evaluation of the black mulberry effects under the symptoms of menopause	Not yet recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1762	Evaluation of Morus nigra L effects on climacteric women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9t4xxk	<NULL>	Women aged between 35 and 65 years old who present climacteric symptoms,among them hot flushes; paraesthesia; insomnia; nervousness; depression; fatigue; arthralgia; headache; palpitation and ringing in the ear	Women with previous or family history of breast cancer; ovarian cancer or endometrial cancer; with hepatic failure; porphyria; abnormal endometrial bleeding; deep vein thrombosis and coronary artery disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-5kqsnp	Addition of blood flow restriction to passive mobilization reduces hypotrophy rate in Elderly Intensive Care Unit patients: A within patient randomized trial	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	1763	Addition of Peripheral Blood Flow Restriction to Passive Mobilization in muscle atrophy in ICU patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Sociedade Pelotense de Assistência e Cultura(SPAC)	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5kqsnp	<NULL>	The inclusion criterion was admitted to the ICU sector of two reference hospitals in Belém, from September to October 2017, and to be admitted to the PM protocol, with the following parameters: Pa02 / Fi02&gt; 300, oxygen saturation (BP) &lt;140 bpm, systolic blood pressure (SBP) 90-180 mmHg, arterial blood pressure (BP) &lt;60 bpm, arterial blood pressure (PaO2)&gt; 90% diastolic (DBP) 50-120 mmHg, respiratory rate of up to 30 breaths per minute and absence of uncontrolled ECG arrhythmias.	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-79wnrc	Effects of aerobic and resistance exercise associated with health care therapy of those who want to quit smoking	Recruitment completed	Intervention	2018-05-04	<NULL>	<NULL>	1764	Efficacy of aerobic and resistance training associated with basic cognitive-behavioral therapy in smoking cessation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-79wnrc	<NULL>	Smoking at least 10 cigarettes / day; age between 18 and 60 years; clinically stable individuals with no change in medications for at least 30 days	"Known pre-existing chronic cardiorespiratory diseases (arrhythmias, uncontrolled hypertension, chronic cough, chronic bronchitis, pulmonary emphysema or FEV1 / FVC  menor que 70%); individuals with pathological conditions that prevent the performance of physical exercise (orthopedic and / or neurological diseases); use of nicotine replacement drugs and / or antidepressants as an aid in smoking cessation; alcohol abuse; pregnant or intending to become pregnant during the exercise protocol; and systematic exercise, for at least 20
minutes a day, three days a week for six months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2tdtct	Electromyography evaluaton of the diaphragm muscle in patients who underwent abdominal surgery in an ICU	Recruiting	Intervention	2018-05-07	<NULL>	<NULL>	1765	Electromyographic evaluation of the diaphragm muscle in patients submitted to high abdominal surgeries with Chevron type incision in intensive care unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Hospital de Clínicas da Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2tdtct	<NULL>	Patients post surgical intervention in the upper abdomen; with Chevron incision as liver transplantation; gatroduodenopancreatectomy and hepatectomies; who will be admitted to the unit still requiring ventilatory support for tracheal orothraqueal tube and mechanical ventilation, both genres and ages between 18 and 70 years	Patients aged less than 18 years or over 70 years; who die in surgical center; who enter an already extubated  in ICU; liver transplant recipients who undergo a new transplant, and those who do not sign the agreement term for some reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-83pwm3	The effect of the aerobic exercise associated to the upper extremity therapy in  individuals after stroke	Recruiting	Intervention	2018-05-07	<NULL>	<NULL>	1766	The effect of the aerobic exercise associated to the constraint-induced movement therapy in chronic hemiparetic individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-83pwm3	<NULL>	Chronic Hemiparetic individuals (more than 6 months) what the vascular accident involved the same hemisphere with lesions restricted to the middle and anterior vascular, report of the imaging test; 18 and 80 years; present a minimum active movement of 45° of shoulder flexion and abduction, 20° of elbow extension, 10° of wrist extension, 10° of abduction or extension of the thumb, and 10° extension in at least two fingers (metacarpophalangeal and interphalangeal joints) and thumb; present asymmetry in the use of the upper limbs with score 2.5 in the Motor Activity Log (MAL) Quantity Scale; ability to remain in a seated position without support for the trunk and/or of the arms for one minute	Individuals with cognitive deficits; smokers; alcohol; users of illicit drugs; with structural abnormalities in the cardiovascular and respiratory systems,  uncorrected auditory and visual deficits, abnormalities on the electrocardiogram such as ischemic changes, arrhythmias, conduction disorders at rest and/or during the clinical exercise test; diseases or osteomiarticular alterations that affect the data collection or generate pain during the activities; obese (Body Mass Index more than 28 kg/ m2); diabetes mellitus and uncontrolled hypertension; comprehension aphasia; apraxia; stroke bilateral or acute or subacute stroke (less than 6 months) or transient vascular accident and other the central and peripheral nervous system diseases; who are participating in other experimental or rehabilitation studies; who have had botulinum toxin application in the last three months prior to evaluation will be not included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-8f5w2q	Effect of brain stimulation by electric current on eating behavior in overweight people	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1767	Effect of transcranial direct current stimulation (tDCS) on eating behavior in participants with excess of	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-06	Faculdade de Ciências da Saúde do Trairi - FACISA	Faculdade de Ciências da Saúde do Trairi - FACISA	https://ensaiosclinicos.gov.br/rg/RBR-8f5w2q	<NULL>	Age between 19 and 50 years; body mass index equal to or greater than 25; abdominal circumference greater than 94 centimeters for men and greater than 80 centimeters for women	Pregnant and breastfeeding women; women in menopause; user of illicit drug, use of psychotropic medication and for weight loss; previous or current history of eating disorder, psychiatric; suffered a stroke, head trauma, neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3cbzwy	Effectiveness of Physical Measures versus Cabergoline for Lactation Inhibition	Not yet recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1768	The effect of Breast Binding with Bandages and Application of Ice Pack versus Cabergoline for lactation inhibition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-3cbzwy	<NULL>	Women with up to 24 hours postpartum; gestational age at delivery of 20 weeks or more; indication for inhibition of lactation: late fetal loss, neomorto up to 24 hours, breast cancer or leukemia in pregnancy or in case of severe maternal morbidity	"Hypertensive syndromes in current gestation; known hypersensitivity to cabergoline; history of cardiac valve disease;
history of retroperitoneal or pulmonary fibrotic disease"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-6xvdmz	NaCl 0,9% vs. Latate&apos;s Ringer&gt; Effects on postoperative results of myocardical revascularization surgery with cardiopulmonary by pass	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1769	NaCl 0,9% vs. Latate&apos;s Ringer&gt; effects on postoperative results of Myocardical Revascularization Surgery with cardiopulmonary by pass	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-05-28	Fundação Universitária de Cardiologia	Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-6xvdmz	<NULL>	Patients submitted to surgical myocardial revascularization with CPB, elective and primary, with age ranging between 50 and 75 years old and both sexes	"Preoperative: Urgency or emergency surgery,  INR higher 1,3, when are lower than 100.000,  altered KTTP in the absence of heparine use, use of antiplatelet agents except acetylsalicylic acid, renal insufficiency and or creatinine higher 2, hepatic insufficiency and or GOT e GPT levels more than two times the normal value, previous coagulopathy, pregnancy, breast-feeding, serum potassium higher 5.5 during preoperative period. Diagnosed diseases Von Willebrand, hemophilia, sepsis, hepatic cirrhosis and seizures
Transoperative CPB duration higher than 160 minutes and realization of profound hypothermia with circulatory arrest"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9fsxnn	The effect of Dental materials for the caries treatment	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1770	Efficacy of protective pulp materials in selective caries removal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9fsxnn	<NULL>	Children between 5 and 9 years of age, of both genders, who do not present systemic pathologies; no history of allergic reaction to the latex of absolute isolation and / or local anesthetic; with a first / second deciduous upper / lower molar compromised by deep caries that reaches two thirds of the dentin; with lack of sensitivity and / or spontaneous pain; absence of pulp exposure; absence of over-mobility; absence of fistula or abscess; radiographic absence of internal and external resorption; radiographic absence of rhizolysis greater than 1/3 of the root; radiographic absence of radiolucent image in the periapical and furcation region that may indicate the presence of irreversible pulpitis or pulp necrosis; apparently healthy local gum and tooth with restorative possibility	Presence of systemic pathologies; history of allergic reaction to latex of absolute isolation and / or local anesthetic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2m2q5c	Contribution of Changing Eating Habits to reduce the risk of Heart Disease and improve the quality of life of wheelchair  basketball players	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1771	Contribution of Nutritional Intervention to reduce the risk of Cardiovascular Diseases and improve the quality of life of wheelchair basketball players	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-23	Centro Universitário de Patos de Minas MG	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-2m2q5c	<NULL>	Athlete of the basketball team in wheelchairs; both genders; aged between 18 and 50 years; practicing the activity for more than thirty days; accepting to participate in the research	Being on medication for weight loss; lipid profile control or glycemic control; being in the use of supplements that interfere in the glucose or lipid metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3878jp	Response of heart rate and blood pressure after exercise on cycle ergometer in subjects after heart surgery	Recruiting	Intervention	2018-05-09	<NULL>	<NULL>	1772	Hemodynamic and autonomic responses of exercise in cycle ergometer in individuals in phase I of cardiac rehabilitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-3878jp	<NULL>	Patients on the second postoperative day of myocardial revascularization surgery; age equal to or greater than 18 years; both genders; conscious and collaborative patients; patients who were hemodynamically stable and without vasoactive drugs	Patients with hemodynamic instability or any factor that impairs or contraindicates sitting and walking; patients with provisional or definitive pacemakers; with acute arrhythmias atrial flutter; atrial fibrillation; second or third degree atrioventricular block; unstable angina; inability to research activities; indigenous patients; institutionalized and quilombolas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-33mjbg	Combined use of Propolis with Antiretroviral Therapy and possible health benefits of HIV-infected individuals	Not yet recruiting	Intervention	2018-05-09	<NULL>	<NULL>	1773	Association of Propolis to Antiretroviral Therapy for HIV-infected individuals: innovation in treatment and possible benefits in immunological, inflammatory and oxidative stress parameters	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto de Biociências de Botucatu - UNESP	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-33mjbg	<NULL>	To have confirmed HIV infection and use of cART with adequate viral suppression for at least three years; have a minimum age of 20 and a maximum of 50, and sign a Consent Form.	cART patients for more than 10 years and / or under rescue therapy; vertical transmission; patients with cancer, diabetes mellitus, cardiovascular or autoimmune diseases; transplanted; patients who exercise regularly; pregnant or lactating women; presence of co-infections such as tuberculosis, viral hepatitis, toxoplasmosis, among others; genetic diseases; treatment with anxiolytics or antidepressants; vitamin supplementation; users of illicit drugs, active smokers and alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-682px9	Evaluation of the effect of dietary control in the treatment of female smokers	Recruitment completed	Intervention	2018-05-09	<NULL>	<NULL>	1774	Evaluation of the effectiveness of nutritional intervention in the treatment of female smokers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-03	Instituto de Medicina Social/ Uerj	Prefeitura da cidade do Rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-682px9	<NULL>	women smokers enrolled in the smoking control program at health units in the western zone of the municipality of rio de janeiro	"pregnant women
women unable to walk"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-4mb9xb	Effects of whey protein associated with stimulation of anterior thigh muscles after anterior cruciate ligament reconstruction surgery	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1775	Effects of whey protein associated with the neuromuscular electrical stimulation of the femoral quadríceps after reconstruction of the anterior cruciante ligament	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4mb9xb	<NULL>	Individuals with unilateral rupture of the Anterior Cruciate Ligament verified arthroscopically or by magnetic resonance imaging and who will undergo Anterior Cruciate Ligament reconstruction surgery	Patients with a history of renal disease; lactose intolerance; diabetes; history of surgery or contralateral knee dysfunction; any dysfunction or surgery in the hips; ankles or feet and for both groups; any neurological, cardiovascular; metabolic; rheumatic or vestibular disease; presence of cardiovascular or respiratory disease that impedes the performance of the study movements and patients who refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3dngn4	Effect of backward walking treadmill training on locomotor capacity after stroke	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1776	Effect of backward training on locomotor capacity of individuals with hemiparesis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3dngn4	<NULL>	People with stroke living in the community will be eligible if they are: &gt; 6 &lt; 18 months after their first stroke;community-dwelling and have been discharged from formal rehabilitation ; capable of providing consent (Mini Mental State Exam score &gt; 23); older than 20 years of age; able to independently walk 10 m without walking aids &gt; 0.4 &lt; 1.2 m/s.	They will be excluded if they have: unstable cardiac status which would preclude participation in a moderate exercise program; severe cognitive deficits and/or language problems which might prevent them from following instructions during the data collection and/or interventions; adverse health conditions which might affect their walking capacity (eg, vestibular disturbances, severe arthritis, or other neurological disorders).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-7k4ttg	Effects of levodopa on masticatory and oral sensory function in Parkinson’s Disease	Data analysis completed	Observational	2018-05-10	<NULL>	<NULL>	1777	Oral health and chewing function in patients with Parkinson’s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7k4ttg	<NULL>	"Case group: volunteer with Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses.
Control group: Paired study"	"Case group: volunteers should not have neurodegenerative disease, except for Parkinson&apos;s disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition.
Control group: Paired study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-32vrj6	Effects of Cardiac Rehabilitation on Exercise Tolerance, Endothelial Function, Heart Variability and Quality of Life in Heart Transplants.	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1778	Effects of Cardiac Rehabilitation on Functional Capacity, Endothelial Function, Cardiac Variability and Quality of Life in Heart Transplant recipients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco-UFPE	Universidade Federal de Pernambuco-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-32vrj6	<NULL>	Individuals with an age range greater than 18 years and less than 65 years of age; of both sexes; who underwent heart transplant surgery in a superior period for 6 months; with clinical stability; using regular immunosuppressive therapy, with no change in class of medications within three months prior to the start of the study	Patients who present with orthopedic, neurological or respiratory diseases that may make it impossible to perform cardiopulmonary and exercise tests; patients who are undergoing dialysis; and those patients who present psychic alterations that restrict them to respond to the questionnaires and the elderly who carry out the test Time up and go in time greater than 20 seconds, characterizing risk of falls	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9jgz9d	Creation of reminders to improve nurses&apos; practice regarding registration and use of the child&apos;s book	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1779	Behavioral technology for nurses to enroll and use the child&apos;s book	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Ceara	Universidade Estadual do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-9jgz9d	<NULL>	Work on family health strategies that perform child care, work on family health strategies that are located in the urban and rural areas of the municipality of barro	Medical license, physical or mental condition that makes it impossible to participate in the research periodo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3n3hwh	The use of Video Game for Rehabilitation in the elderly	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1780	Effect of Virtual Reality as new tool for Physiotherapy of older: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Escola de Educação Física da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3n3hwh	<NULL>	Elderly sarcopenic;age 65 or older;with postural instability	Cognitive changes;Inability to stand without help;Inability to perform independent gait; Lesions and/or musculoskeletal symptoms that make it impossible to perform the training; fractures and/or orthopedic lower limb surgeries in the last year;Diseases of the labyrinth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-59h84g	Description of health-related quality of life and evaluation of the use of Cosmetic Camouflage in patients with Systemic Lupus Erythematosus and skin scars caused by the disease	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1781	Impact of the use of Cosmetic Camouflage on health-related quality of life in patients with Systemic Lupus Erythematosus and cutaneous manifestations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Santa Casa de Misericórdia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-59h84g	<NULL>	Age greater than or equal to eighteen years; signature of the Informed Consent Term (TCLE);presence of scars of cutaneous manifestations of the disease on the face	Moderate to severe disease activity at the time of inclusion or during the study (defined as SLEDAI 2k-Modified&gt; 4, excluding cutaneous manifestations); not understanding the questionnaires; patients who have initiated psychological and / or psychiatric treatment, with or without medication, within four weeks prior to the start of the study and during its execution or who have undergone treatment modification during the study; development of allergic reaction to the cosmetic product used; moderate to severe cutaneous activity assessed by a rheumatologist	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9g8d46	Cardioprotective effects of Electro-acupuncture	Not yet recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1782	Cardioprotective potential of Transcutaneous Electro-Stimulation in Acupuncture points in the preoperative Heart Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9g8d46	<NULL>	All patients between 18 and 80 years of age; who undergo an exclusive surgical procedure of valve replacement; and are hospitalized preoperatively at the National Institute of Cardiology will be eligible for the study.	Patients who present in the initial evaluation will be excluded from the study; pregnancy; presence of a cardiac pacing device; intermittent cardiodesfibrillator; hearing devices; skull trauma; brain injury; status epileptics; tetanus; adult respiratory distress syndrome; chronic liver disease; chronic kidney diseases; patients taking Sulfonylurea; Glibenclamide; who have already had previous heart surgery; cognitive alterations that impede the accomplishment of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7fpgzg	Verification of children&apos;s behavior and anxiety in relation to the dental procedures of canal treatment and dental extraction	Recruitment completed	Intervention	2018-05-12	<NULL>	<NULL>	1783	Evaluation of behavior and anxiety in endodontic and exodontia treatments in schoolchildren aged 6 to 9 years	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-03	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7fpgzg	<NULL>	Children of both sexes were considered; age group from 6 to 9 years of age; need to have indication of at least one of the three treatments proposed, according to their indication, fluoride prevention, fluoridation, endodontics or exodontia; the criteria for indication of preventive treatment or application of fluoride: children who did not present the caries disease and showed poor oral hygiene, thus could have low, medium or high risk of developing caries disease; or children presenting with cavitated lesions; endodontic criteria: primary molars presenting carious lesions or defective restorations associated with signs or symptoms indicative of irreversible pulpal inflammation (spontaneous pain or pulp necrosis, presence of abscess, fistula, edema, periapical or interradicular lesion), which had at least two thirds of remaining root; Finally, criteria for indication of extraction: primary molars that had pulp involvement, perforation of the floor of the pulp chamber, bone resorption involving the permanent crypt, internal resorption or pathological or physiological external resorption compromising more than a third of the length of one of its roots, or teeth that had invasion of the biological space which did not allow the absolute isolation and / or subsequent adequate restoration	Children who were taking medicines that interfered with the central nervous system; children with special needs; children and / or parents and non-literate parents; refusals of participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-4g6fhf	The Effects of Exercise with Cycleergometer in Patients after Acute Stroke	Recruitment completed	Intervention	2018-05-12	<NULL>	<NULL>	1784	Effects of the Cycleergometer on the motor control, ventilatory, cognitive and functional capacity of patients victims of Acute Vascular Cerebral Accident	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Irmandade Santa Casa de Misericórida de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4g6fhf	<NULL>	Individuals of both sexes; aged between 60 and 75 years; who were affected by ischemic stroke with hemiparesis or hemiplegia; being the first episode of stroke; who obtained a Minimum Mental State score greater than 21 for cognitive deficits; although he was illiterate with at least 13 points and signed the Term of Free and Informed Consent	Individuals with hemodynamic instability, including tachycardia or bradycardia, desaturation and fever; Glasgow scale 8, patient with bilateral or brainstem lesions, pathological changes in the electrocardiogram that make it impossible to perform the protocol, among them: ventricular fibrillation, ventricular tachycardia, atrioventricular block; have a significant change in blood pressure at rest, with a systolic blood pressure greater than 200 mmHg or a diastolic blood pressure greater than 100 mmHg; patients with decompensated heart failure or who are using beta-blockers; those who suspect and / or clinical signs of a new stroke; present a history of previous cognitive disease: as dementia or Alzheimer; patients with osteoarticular alterations that prevent the performance of tests and therapy, such as shoulder dislocation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2cwy5d	Effect of a Therapy for discomfort in the musculature of the neck region in adults	Not yet recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1785	Effect of Radiofrequency in the contract of the  trapezius upper muscle in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-14	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2cwy5d	<NULL>	Adult patients between 18 and 40 years of age; pain and muscle contracture in the upper trapezius muscle	Subjects with altered sensitivity; intraorganic metal implants; osteosynthesis; electric implants; pregnant women; subjects on drug therapy for blood circulation (use of vasodilators or anticoagulants); hemophiliacs; subjects with outbreaks of infection and with fever; elitist neoplastic disease; in topical or non-muscle relaxation treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2szg8b	The effect of ozonated oil on patients with osteoarthritis.	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1786	Ozonated oil via topic in degenerative articular disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2szg8b	<NULL>	Patients over 50 years of age; Patients who self report having the diagnosis of osteoarthritis.	Patients who have severe cognitive disorders;cancer patients; hospital discharge for less than 30 days; or indigenous people; or have, in addition to osteoarthritis, another chronic inflammatory disease will affect the laboratory results of this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-93dp9n	Efficacy of Sofosbuvir as treatment for Yellow Fever	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1787	Efficacy of Sofosbuvir as treatment for Yellow Fever: randomized clinical trial (SOFFA trial)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Fundação Faculdade de Medicina	Fundação Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-93dp9n	<NULL>	Age above 18 years, admission in one of the recruiting centers, fever (axillary temperature above 37.8°C), coming from a risk region with epizootic or confirmed human cases (defined according to updated epidemiological bulletins), transaminases above 500 U/L.	amiodarone use in the last 72 hours,  current pregnancy, women who do not accept interruption of breastfeeding, current use of sofosbuvir for hepatitis C treatment, negative RT-PCR for yellow fever, alternative diagnosis that justifies the symptoms on admission.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2pqvv4	Restorations in traumatized permanent anterior teeth	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1788	Restorations in traumatized permanent anterior teeth: a clinical, controlled and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2pqvv4	<NULL>	Age between 8 and 14 years old; having a permanent upper anterior tooth (central incisors, lateral incisors or canines) requiring class IV restoration, due to uncomplicated coronary fracture, physical and emotional conditions capable of tolerating the restorative procedure, pulp vitality and accept to respond to the questionnaire applied.	Patients with pulpal inflammation or necrosis; previous endodontic treatment; uncontrolled periodontal disease; parafunctional habits; special needs or motor deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-9j9myd	Effectiveness of an intervention designed to provide greater well-being	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	1789	Positive psychology and gratitude interventions: An randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9j9myd	<NULL>	Adult volunteers; minimum age of 18; both genders; active email account	Age less than 18 years; inactive email account; failure to complete the initial scales of the study and the sociodemographic questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7mx2d5	Online Psychotherapy for alcohol dependents from a Specialized web site	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	1790	Brief psychotherapy internet deliveried for alcohol and drug dependents	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-13	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7mx2d5	<NULL>	Men and women volunteers; score higher than twenty points at AUDIT; having an valid email acccount; use of alcohol on the thirty previous days	Abusive or dependent use of other drugs except tobaco; participation on alcohol specialized treatment;severe mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7y6f3j	Effect of video game training and conventional physiotherapy on improving the balance of the elderly	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1791	Effects of Cognitive Motor Training in real and virtual environments on postural control of the elderly: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7y6f3j	<NULL>	Community dwelling elderly individuals, aged 65 years or over; of both sexes; with a functional state capable of remaining standing, and walking without assistance; without cognitive impairment in the Mini-Mental State Examination89 (&lt;18 for illiterate individuals and &lt;26 for those with an educational level greater than 8 years); normal or corrected hearing acuity (Whisper Test)90; normal or corrected visual acuity (Snellen)91; with no prior experience with the games of the system; and who sign the Free and Clear Informed Consent.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-69cdyf	Ergometric Bicycle Exercise associated with Continuous Positive Airway Pressure in patients after Cardiac Surgery	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	1792	Non-Invasive Ventilation associated with the Ergometric Bicycle in Cardiac Rehabilitation in the hospital phase: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-08	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-69cdyf	<NULL>	"Individuals undergoing cardiac surgery of both sexes;
Between eighteen and seventy five years;
That they agree to participate in the study;
No postoperative complications that delay hospital discharge greater than eight days of hospitalization."	"Individuals who are unable to understand and follow the research procedures;
Patients who have postoperative complications of cardiac surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-3g38dx	Effects of two sessions of Physical Training on the genetic means in women aged 50 to 70 years	Recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1793	Global Screening of Genetic and Epigenetic factors sssociated with magnitude of response to different Physical Training in women 50-70 Years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g38dx	<NULL>	Woman aged 60 and over 70 and present medical clearance certificate for physical exercise	To reach a score below the cut-off point in the cognitive performance assessment performed by the Montreal Cognitive Asessment; to be diagnosed with some neurological disease and to present auditory, visual and motor deficits; to be currently smokers and / or in the last six months and to consume caffeine in the last 24 hours before the collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2vzd48	Development and application of a Phosphorus Counting Table for control of blood level of phosphorus in patients with Bone Disease in hemodialysis	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1794	Characterization and application of a Phosphorus Counting Table for control of hyperphosphatemia in patients with Bone Mineral Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vzd48	<NULL>	Patients with chronic kidney disease and disease–mineral and bone disorder in hemodialysis; age range greater than or equal to 18 years; literate or had literate carer; serum phosphorus levels less than or equal to 7,8mg/dL after thirty days of phosphate binder cessation; sign the written informed consent form	Patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-84zdp6	Effect of physiotherapeutical treatment on hip pain in women	Not yet recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1795	Randomized clinical trial: The effect of a physiotherapy protocol in Greater trochanteric pain syndrome in women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Paulista, Faculdade de Filosofia e Ciências	Universidade Estadual Paulista, Instituto de Biociências	https://ensaiosclinicos.gov.br/rg/RBR-84zdp6	<NULL>	Clinical diagnosis of major trochanter pain syndrome, chronic lateral pain in the hip greater than or equal to 3 months, presenting pain (4/10) in the visual analogue scale, tenderness in the trochanter region (4/10), pain during daily activities, pain in at least 1 of the 7 provocative clinical tests of pain, which is intended to transmit compressive or tension forces in the tendons of the abductor gluteal muscles. To present age and gender comparable to the intervention group	Presenting a body mass index more than 36 kg / m2, received some type of invasive intervention to reduce pain in the region evaluated in the last year, physiotherapeutic intervention in the last three months, present any limitation in the range of motion of the regions of the column, hip or MMII that disables gait or testing, any disease that affects the neuromuscular system or that may prevent collection, surgery on the spine or hip, any infectious condition, any neoplasia or can not commit to the weeks of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-83j396	Comparison of brain connections post open-surgery or carotid angioplasty through functional Magnetic Resonance Imaging	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1796	Brain connections analysis post Endarterectomy versus Stent carotid Angioplasty by functional Magnetic Resonance in rest state	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-23	Instituto de Neurologia e Neurocirurgia de Passo Fundo	União Brasileira de Educação e Assistencia	https://ensaiosclinicos.gov.br/rg/RBR-83j396	<NULL>	Patients 18 years old or older; with carotid stenosis above 60% asymptomatic; or patients who had a transient ischemic attack (TIA) with carotid stenosis above 50%; or ulcerated plaque;  who agree to participate in the study	Patients with severe neurological disease such as parkinsonism, dementia, epilepsy, defined cerebrovascular disease, encephalopathy, severe depression; Patients who use drugs that directly affect the central nervous system, which prevent individualized natural responses to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-8chg6q	Effects of muscle stretching on pain	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1797	An exercise program for Postural Correction and Pain symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8chg6q	<NULL>	Nursing professional; officer of a polyclinic in the city of niterói-rj; ages between 18 and 60 years; to present some postural deviation; do not practice any physical activity oriented during the period of participation in the research	Inability to perform tests and stretching exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7mry33	Surgical aperture for irrigation of the bowel in children with Constipation	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1798	Appendicostomy for the Anterograde Enema in children with Refractory Constipation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7mry33	<NULL>	Patients on follow-up in a tertiary medical care service diagnosed as refractory constipation	Patients who do not fill the diagnosis of refractory constipation criteria that is: persistence of retentive incontinence for at least 12 months on maximum tolerable doses of oral laxatives and rectal enemas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7pyznv	Training of Breathing Muscles in children after renal Transplantation	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1799	Inspiratory Muscle Training in pediatric patients after kidney Transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-22	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7pyznv	<NULL>	Renal transplant recipients up to six months post-transplant; of both sexes; aged between 6 and 18 years; under follow-up at the Nephrology Outpatient Clinic of Santo Antonio Children’s Hospital; and whose parents or guardians agree to participate by signing the written informed consent	Patients with severe underlying lung disease; associated neurological disease; orthopedic disease that not allow the test performing; contraindicated patients to perform pulmonary function tests according recommendations from Brazilian Guidelines for Pulmonary Function Testes; patients with cognitive difficulty to understand and perform tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-5m3s2s	Effects of physical exercise associated with music on behavioral, functional and mental aspects in older people with dementia who live in nursing homes	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1800	Behavioral, functional and mental factors and the Effects of Physical Exercise associated with Music in institutionalized older people with Dementia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-27	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5m3s2s	<NULL>	People aged 60 years old and over; living in nursing homes; dementia diagnosis; availability to participate in the proposed evaluations.	Severe and uncorrected auditory disorder that prevents the participant from hearing music; any cardiovascular or infectious comorbity described in the absolut contraindications list of Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aneurism of aorta, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardical infarction, acute myocarditis, pulmonary or acute systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-9s356k	Physiotherapy for Urinary Incontinence resulting from treatment of Cervical Cancer	Recruitment completed	Intervention	2018-05-16	<NULL>	<NULL>	1801	Physiotherapy in Urinary Incontinence resulting from the treatment of Cervical Cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade do Estado do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-9s356k	<NULL>	Women aged between 25 and 65 will be included in the survey; who have had treatment for cervical cancer; that show Karnofsky Performance Status above 70%; who have stopped treatment for cervical cancer for a maximum of one year and at least one month; who present with urinary incontinence; the participants must present conditions of full control so that they have the autonomy to sign the informed consent form	Women residing in the interior of the State of Pará will be excluded from the survey; that present metastases; who have other pathologies associated as neurological problems; cardiac disorders; respiratory and diabetes mellitus; metal plates; pacemaker; who already had urinary incontinence prior to treatment for cervical cancer and local infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-8xkj95	Sertraline Use on prevention of intradialytic low blood pressure	Recruitment completed	Intervention	2018-05-16	<NULL>	<NULL>	1802	Effect Sertraline use on prevention of intradialytic hypotension	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8xkj95	<NULL>	18 years of age or over; both sexes; with kidney failure; who undergo hemodialysis three times a week, with a duration of each session of at least three hours. Patients eligible for the study should present intradialytic hypotension defined by the above criteria in at least 50% of the hemodialysis sessions of the last three months prior to the start of sertraline use	Patients with psychiatric disease or major cognitive deficits; history of drug abuse; patient refusal; refusal of the patient&apos;s physician	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-776gwc	Comparison of continuous aerobic exercise effect with interval high intensity exercise in patients with heart failure	Recruiting	Intervention	2016-05-12	<NULL>	<NULL>	1803	Effect of high intensity interval training verses moderate intensity continuos training in functional capacity and quality of life of patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal de Minas Gerais	Hospital Messejana Dr. Carlos Alberto Studard Gomes	https://ensaiosclinicos.gov.br/rg/RBR-776gwc	<NULL>	Individuals with heart failure ; functional classes II and III of the New York Heart Association ( NYHA) ; ejection fraction less than 50%; both genders ; medical clearance ; optimal medical treatment	Subject that presented new cardiac event; clinical decompensation against that indicate the continuity of the physical activity program; and / or to submit physical limitation that prevents participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-4cpbr5	Effects of diamond peeling on spots in the female inguinal region	Data analysis completed	Intervention	2018-05-16	<NULL>	<NULL>	1804	Effects of diamond peeling on hyperchromic spots and folliculitis in the female inguinal region	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4cpbr5	<NULL>	Women older than 18 years; presence of hyperchromic spots in the inguinal region; literate; able to respond to research questionnaires	"Women who were in dermatologicalfunctional treatment to improve the hyperchromic spots of the inguinal region; predisposition to keloids; tissue lesions and infectious skin disease; presence of hormonal, cardiac, respiratory diseases, diabetes mellitus, systemic arterial hypertension and neoplasms;
inability to provide sensitive feedback or with changes in cutaneous sensitivity; not to attend three consecutive days of treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-67h649	Comparison between two IUD immediate postpartum	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1805	Comparison between copper IUD (intrauterine device) and levonogestrel-releasing system immediate postpartum - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-67h649	<NULL>	Age between 18 and 43 years; gestational age at delivery greater than or equal to 37 weeks; hemoglobin major than 8.0 during prenatal care; desire to use IUD as contraceptive method; immediate Postpartum of single gestation	Diagnosis or suspicion of ovular infection; diagnosis of any other infection (anywhere); active STD (sexually transmitted disease); uterine malformation (bicorn, septate);uterine myomatosis that deforms the cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-73x5yc	Effect of a Mother-oriented treatment and physiotherapy on the Mother&apos;s Anxiety, number of Gusts and Cry time in young and healthy babies	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1806	Effect of an intervention with Maternal Care guidelines and Manual Therapy on Maternal Anxiety, number of Regurgitations and time of Crying in young and healthy infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-73x5yc	<NULL>	Mothers over 18 years of age with full term newborns greater than or equal to 37 weeks of gestational age and less than 42 weeks of GI, healthy, with an Apgar score greater than 7 at the fifth minute, and with age-appropriate birth weight gestational	Mothers with impaired comprehension and verbal language will be excluded. It will be excluded newborns with Apgar less than seven in the fifth minute, malformation, neurological disease, congenital infection, and infants who throughout the study have a diagnosis of gastroesophageal reflux disease, with a history of aspiration, apnea, growth restriction , weight loss and difficulty in swallowing, allergy to cow&apos;s milk protein, in this study considered as presence of blood in the stool, inflammation of the anus, severe atopic dermatitis and use of formulas to treat food allergy; history of seizure and  or diagnosis of metabolic disease and use of medications such as domperidone, bromopride, metoclopramide, omeprazole and ranitidine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5s4czx	Acupuncture to treat the symptoms of Premenstrual Syndrome - randomized controlled study	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1807	Acupuncture as a therapeutic resource for treatment of symptoms of Premenstrual Syndrome - a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-5s4czx	<NULL>	Will include women aged between 18 and 40 years; presence of at least one physical symptom and one emotional symptom in the pre-menstrual and/or menstrual period observed in the two cycles prior to the study in non-users or users of oral contraceptives and who present three regular menstrual cycles before the study.	Women who use anxiolytics or antidepressants will not be included; with liver diseases; carriers of coagulation disorders, oophorectomized; carriers of cancer or serious diseases; carriers of psychiatric illnesses; history of radiation therapy or chemotherapy; illicit drugs and/or excessive alcoholic beverages, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-7qhv4f	Evaluation of bone loss around implants with Morse cone connection	Data analysis completed	Intervention	2018-05-17	<NULL>	<NULL>	1808	Biomechanical analysis of hybrid titanium-based abutments in Morse taper implant connection	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-26	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7qhv4f	<NULL>	Sufficient bone dimensions to install an implant with a Morse cone-type implant of at least 3.5 mm in diameter and 8 mm in height; Satisfactory oral hygiene	Patients with systemic diseases that compromise the technique. With severe maxillomandibular discrepancies. With severe parafunctional habits. Drug users, alcohol or smoking abuse (greater than 10 cigarettes / day). With coagulant or anticoagulant therapy. Immunosuppressed and / or irradiated. With oral disease requiring prior treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-8wyp8j	Effect of an educational intervention for the prevention of complications of Gestational Hypertension Syndrome	Recruitment completed	Intervention	2018-05-17	<NULL>	<NULL>	1809	Effect of an educational intervention for the prevention of complications of Gestational Hypertensive Syndrome: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-8wyp8j	<NULL>	Pregnant women; gestational age up to 33 weeks; literate	Pregnant women over 33 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-2xkfs3	Effect of labyrinth stimulation exercises associated with the repositioning technique in patients with benign paroxysmal positional vertigo	Recruitment completed	Intervention	2018-05-17	<NULL>	<NULL>	1810	Efficacy of vestibular rehabilitation in the treatment and spacing of seizures in patients with Benign Paroxysmal Positional Vertigo	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-10	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2xkfs3	<NULL>	Age above 18 years; with diagnosis of Benign Paroxysmal Positional Vertigo; test of Dix-Hallpike or Roll test positive	Central vestibular disorders; Dix-Hallpike and Roll test negative; use of vestibular suppressive drugs; motor restraint; visual restriction; cognitive restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-9wfsyj	Ideal time for Umbilical Cord Tightening for the baby	Not yet recruiting	Intervention	2018-05-17	<NULL>	<NULL>	1811	Ideal time for Umbilical Cord Clamping for the newborn: a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-25	Universidade Federal de Alagoas	Escola de Enfermagem e Farmácia	https://ensaiosclinicos.gov.br/rg/RBR-9wfsyj	<NULL>	Parturient in the period of expulsion of normal labour at normal risk and cephalic presentation; with gestational age greater than or equal to thirty seven weeks calculated by the date of the last menstrual period and or by the result of the precocious ultrasonography until the twentieth week; being this age of the newborn confirmed through Capurro method after birth. Newborns of normal delivery with cephalic presentation with an Apgar score seven in the fifth minute, which considers the characteristics of respiratory rate, heart rate, colour, muscle tone and irritability of the newborn at birth	Newborns presenting: maternal-infant Rh factor incompatibility; Neonatal anoxia; Neonatal malformations and parturient with fetus without vitality or in fetal distress; parturients who present any clinical or obstetric complications that justify the accomplishment of cesarean delivery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-3nfxvx	Randomized clinical trial comparing the use of high-flow nasal catheter vs. traditional nasal catheter after anesthesia for orotracheal intubation of preoperative patients with traumatic orthopedic surgeries	Not yet recruiting	Intervention	2018-05-17	<NULL>	<NULL>	1812	Randomized clinical trial comparing the use of the High flow nasal cannula (HFNC) vs. Traditional nasal cannula after anesthetic induction for orotracheal intubation of preoperative patients with Traumatic orthopedic surgeries	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-31	Hospital Universitário da Universidade Federal de São Paulo	Hospital Universitário da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3nfxvx	<NULL>	Patients of both sexes will be included; older than 18 years; with indication of traumatic orthopedic surgeries.	Patients younger than 18 years will be excluded; carriers of previously known chronic lung disease; and patients with hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-946bv5	Immunity of the Vaccine against Yellow Fever in patients taking medications that affect the immune system	Recruitment completed	Observational	2018-05-18	<NULL>	<NULL>	1813	Yellow Fever Vaccine immunity in patients using immunomodulatory therapies	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-09-17	Centro de Pesquisas René Rachou- FIOCRUZ	Centro de Pesquisas René Rachou- FIOCRUZ	https://ensaiosclinicos.gov.br/rg/RBR-946bv5	<NULL>	Be over 18 years of age; to present a diagnosis of Rheumatoid Arthritis; being in use of immunosuppressants; be accompanied at the University Hospital of Brasília; have previously been vaccinated against yellow fever	Pregnant women ; organic mental illness; carriers of other autoimmune diseases or neoplasms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5dsrhv	Comparation of treatments of temporomandibular joint problems	Data analysis completed	Intervention	2018-05-18	<NULL>	<NULL>	1814	Comparative study of temporomandibular disfunction therapies: randomized blind controled clinical trials	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia da Universidade Federal do Ceará	Faculdade de Odontologia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5dsrhv	<NULL>	Female gender; age between 18 and 59 years; diagnosis temporomandibular dysfunction; adequate bilateral occlusal contacts between molars and premolars; history of orofacial pain, at least during the last 6 months; absence of previous treatment for pain; pain intensity equal to or greater than 7 on a visual analogue scale from 0 to 10; good receptivity and understanding of spoken Portuguese; ability to provide free and informed consent; and availability for attendance to evaluation returns	Abuse of alcohol or illicit drugs; use of antidepressant or antipsychotic medications in the three months prior to the survey; hypersensitivity to the drugs proposed in the research; history of rheumatic or vascular disease; neurological disorders or any systemic base disorders; patients with motor or mental disorders; pregnant women, and patients who suffered some type of macro or microtrauma on the face	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-3zvgwb	Study of Solutions of Darkened Color during the Bleaching Treatment with two types of gels, regarding Color Change and Dental Properties	Data analysis completed	Intervention	2018-05-19	<NULL>	<NULL>	1815	Influence of Staining Solutions used during Dental Bleaching with high and low concentrations of Peroxides on color change and Enamel Surface Properties	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade São Leopoldo Mandic	Fundação de Amparo a Pesquisa no Estado de São Paulo-FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-3zvgwb	<NULL>	"Healthy patients between ages 18 and 30 years who have at least 24 teeth.
Female or male"	People wearing dentures or fixed/removable orthodontic appliances; Pregnant or lactanting women; smokers; Patients who take medication that can cause salivary flow reduction (antihypertensives, anticonvulsants, for example).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-66yr4x	Effects of training in lower limb exercise in patients after cardiac surgery	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1816	Effects of training cycle ergometer in patients after cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-66yr4x	<NULL>	cardiac post-surgical patients hospitalized in the ICU; of both sexes; aged 18 years or older; level of light sedation; without sedation or who are level-2 to zero by the sedation scale of Richmond Agitation Sedation; vasoactive and / or inotropic drugs less than 0.5 mg / kg / min; mean arterial pressure between 60 and 100 mmHg; heart rate between 60 and 120; muscle strength 3 by the manual muscle strength test Medical Research Council (MRC); functional independence prior to hospitalization. And the ventilatory parameters used are: FiO2 bigger than 60%; PaO2 bigger than 70mmHg; PEEP less than 8; SpO2 bigger than 90%; f less than 35irpm	Those who give up the research; evolve to death or need to be reopened surgically	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-2sk64p	Effect of a small book on home care of preterm infants	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1817	Effect of an educational technology on the home stimulation of preterm infants: clinical, non-randomized trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Enfermagem da Universidade de São Paulo	Hospital e Maternidade Rede D'OR São Luiz - Unidade Anália Franco	https://ensaiosclinicos.gov.br/rg/RBR-2sk64p	<NULL>	Family of children born with any level of prematurity who have been hospitalized in Neonatal Intensive Care Unit	Non-resident family members in the municipality of São Paulo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-7pc86g	Evaluation of the Ipelvis Application in Women&apos;s Urinary Loss	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	1818	Evaluation of the Ipelvis Application on feminine urinary disfunctions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-09	Faculdade Inspirar	Hospital de Clínicas - Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7pc86g	<NULL>	Urinary urgency; stress and mixed urinary incontinence; with ages between 18 and 59 years, with objective demonstration of urinary loss that have cognitive ability; have a compatible cell phone for installation of the Ipelvis application and who sign the Informed Consent Term	They shall be excluded from the statistical analysis women with up to six months postpartum; women with prolapse greater than Stage III by Pelvic Organ Prolapse - Quantification; women with urinary tract infection; women with pelvic pain that prevent achievement Of therapies offered or who have undergone pelvic surgery in a period of less than six months; Pacemaker or contraceptive device; Women with intrapelvic tumor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-8ndsbq	Effects of High Intensity }Training on health of younger with Obesity	Recruitment completed	Intervention	2018-02-24	<NULL>	<NULL>	1819	Effects of High Intensity Interval Training on factors associated to physical and mental health and behavioral changes in younger adults with Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	Universidade Federal de São Paulo Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-8ndsbq	<NULL>	Subjects will be included if they are young male adults 18 to 30 years old. Obese BMI 30.0 to 39.9 kg / m². Eutrophic BMI 18 to 25 kg / m² according to criteria established by the World Health Organization.	Exclusion criteria are. Positive responders for one of the questions of the physical activity readiness questionnaire (PAR-Q). Genetic, metabolic or endocrine disease – other than obesity (self-reported). Chronic alcohol consumption. Previous use of drugs which could modulate the outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-358sm6	Electrical stimulation in individuals with difficulty coordinating body movements	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	1820	Transcranial direct current stimulation in individuals with Cerebellar Ataxia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade de Medicina da Bahia	Faculdade de Medicina da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-358sm6	<NULL>	Individuals with non-progressive or slowly progressive cerebellar ataxia; literate; independent gait; magnetic resonance imaging of the brain showing diffuse cerebellar atrophy	Individuals with treatable cerebellar ataxia or other associated diseases; intellectual deficit; brain malformations; severe visual or auditory deficits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-6tps79	Motor function in patients with brain injury submitted to an exercise protocol	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1821	Functional Impact in Patients with Acute Brain Injury undergoing an Early Mobilization Protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6tps79	<NULL>	Individuals who have suffered acute brain injury; diagnosed and confirmed by clinical history and cranial tomography; admitted to the intensive care units of the Santa Casa de Campo Grande Hospital; above 18 years; of both sexes and that the persons in charge of the same are in agreement with the term of free and informed consent	Patients with evidence of pre-existing chronic brain injury; presence of external orthopedic fixators; presence of skeletal traction for fracture treatment; presence of lower limb amputation; trauma or previous surgery of the feet, pelvis or lumbar spine; presence of open abdominal wound; unstable bone injury of the spine or lower limbs; severe agitation; spinal cord involvement; pregnant women; indigenous peoples; quilombolas or institutionalized	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-9b6mnj	Laser for temporary treatment of pain in the temples, face and neck.	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1822	Low laser therapy in palliative care of temporomandibular dysfunction and orofacial and cervical cranial pain	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-24	Faculdade de odontologia da Universidade de São Paulo	Faculdade de odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9b6mnj	<NULL>	Adult participants of all ages with primary complaint of pain in the temporomandibular joint region and or orofacial and cervical skull region and or limitation of mouth opening will be included	Participants with: congenital problems with Temporomanbibular joint involvement and or orofacial and cervical skull region; neoplastic conditions; history of recent trauma in the orofacial and cervical skull region; any type of temporomandibular dysfunction treatment plaques; functional orthopedic appliances or fixed and or removable orthodontic appliance; syndromes; cleft lip and or palatine; psychiatric disorders; severe heart problems; tooth in severe precarious conditions, such as periodontitis and or indication of endodontic treatment; in use of topical or systemic photo sensitizing medications, pregnant women, skin related problems in the region to be applied the laser.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-67zvpn	Protective test to prevent nose lesions of babies that require oxygen supplied through continuous positive airway pressure with prongs	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1823	Efficacy of a nasal protector model in prevention of local lesions for newborns utilizing continuous positive airway pressure with prongs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-67zvpn	<NULL>	Newborns hospitalized in neonatal intensive or intermediary care units of the institutions chosen as place of this study; independent of city or institution of birth, which requiring positive pressure ventilatory support associated with the continuous positive airway pressure with nasal prongs interface; on admission or after initial invasive mechanical ventilation	Newborn with pre-existing nasal deformities detected during physical examination; newborn with congenital malformations of upper respiratory tract; newborn with large congenital or macrosomia anomalies; newborn with persistent physiological instability; newborn with coagulation disorder, or shock; newborn that terminates the use of positive pressure ventilatory support with continuous positive airway pressure with nasal prong before the period established for process monitoring	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-4fhbrp	Registry of patients with Pulmonary Hypertension in Southern Brazil	Recruiting	Observational	2018-05-21	<NULL>	<NULL>	1824	"Registry of patients with Pulmonary Hypertension
in Southern Brazil"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-10-02	Irmanda da Santa Casa de Misericórdia de Porto Alegre	Freda	https://ensaiosclinicos.gov.br/rg/RBR-4fhbrp	<NULL>	"Male or female patients residents in southern Brazil, of any age with a confirmatory
diagnosis of pulmonary hypertension by a right heart catheterization, from 01.Jan.2006
until 31.Dec.2017.
Patients with pulmonary hypertension from group I to V according to clinical
assessment by WHO, version 2014.
Available right heart catheterization documentation at the time of PH diagnosis
period."	"Patients with confirmatory PH diagnosis outside the specified period will be
excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-9xh4fc	Repair resin restorations on human teeth: longevity	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	1825	Composite resin repairs in anterior and posterior teeth: randomized-controled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Faculdade de Odontologia da Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9xh4fc	<NULL>	"- Participants must be over 18 years old;
- Presence of four or more composite resin restorations. The restorations should be classified with the Bravo score (USPHS) in one of the following criteria: marginal discolouration, retention, fracture, marginal adaptation, postoperative sensitivity and recurrence of dental caries.
- Presence of at least 20 teeth in occlusion, including the antagonists of the teeth involved in the study."	"People with high risk of dental caries or periodontal disease;
Orthodontic patients with fixed appliances
Presence of parafunctional habits, such as bruxism;
Presence of any oral pathology that makes dental restorative treatment impossible;
smoking;
Pregnant women and lactating."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-5t6bd9	Clinical evaluation of dental bleaching with violet LED	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1826	In vivo analysis of Violet Led associated or not with peroxides on the efficacy and safety of dental bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5t6bd9	<NULL>	"Sign Informed Consent Form; agree to not participate of any other clinical trial during this study; present good general and oral condition;
have not been undergoone dental bleaching over the last 3 years or to present shade higher than A2 (vita SCALE); teeth submitted to dental bleaching with vitality; not present any edentulous space between premolars in both arches; upper right central incisor and canine must present shade higher than A2; the participant must be over 18 and under 60 years old."	Be participating of another clinical trial; not agree to afford for the displacement until the Dental School; present dental caries or gengivitis after clinical examination; present any allergy to one of the materials used in the clinical procedures for bleaching and mineral content analysis; not be able to attend all the appoitments necessary until the end of the treatment; patients with cracks on the teeth that will receive bleaching, once this could enhance tooth sensitivity; present upper right central incisor and canine brighter than A2; present wide restorations on the teeth that will be bleached.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-7nbnpc	Effects of photobiomodulation therapy applied immediately before resistance training in type 2 diabetic women	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	1827	Low-Power Laser Effects Applied to Resistant Pre-Training in Old Type 2 Diabetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Associação Educacional Nove de Julho	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7nbnpc	<NULL>	Women aged 60 to 79 years were included; diagnosis of Type 2 Diabetes Mellitus for at least 1 year; cognitive score greater than 18 in Minimental; glycated hemoglobin above 6.5%; casual blood glucose up to 250 mg / dl; body mass index up to 40kg / m2; make use of insulin only as supplementation of glycemic control; normal or controlled systemic blood pressure with medication; released by the doctor to physical exercise	As voluntárias foram excluídas se realizassem exercícios físicos regulares ou fisioterapia motora; na presença de alterações auditivas; visuais e/ou motoras severas; ou ainda qualquer situação de saúde que impedissem a aplicação dos instrumentos avaliativos e a execução da intervenção proposta. Foram excluídas ainda se tivessem 2 faltas consecutivas ou 3 faltas alternadas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-3wghh4	Comparison of Polishing systems of veneers in anterior teeth	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1828	Effect of the Polishing System on surface roughness of composite resin veneers: randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-16	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3wghh4	<NULL>	"Be at least 18 years old; good general health; do not present periodontal disease;
Coronal darkness and/or extensive and defective restorations covering the buccal face or color and shape alterations that compromise dental esthetics; ; have an anterior tooth with a higid buccal surface for the purpose of comparison of gloss; present opposing and adjacent tooth; patients without systemic disease or allergies to the materials used; absence of parafunctional habits"	Use of removable prostheses with support on the teeth used for the sturdy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-36bjsc	Effects of supplementation with medicinal effect on the desire to eat and quality of sleep, blood glucose and cholesterol, weight loss and waist reduction	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	1829	Effects of supplementation with functional oils on behavioral, metabolic and anthropometric parameters in obese women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-36bjsc	<NULL>	Healthy women; obesity grade 1 and 2; who had abdominal obesity defined by waist circumference bigger then 88cm; age between 20 and 40 years	Pregnant women; smoking; with history of cardiovascular, hepatic, renal, neurological, hematological, oncological, endocrine and gastrointestinal diseases; with a history of eating disorder or who had any significant psychiatric disorder such as depression or psychosis; with a history of allergic reactions; presence of infections or use of drugs with interference in the lipid or glucose profile or those with severe dyslipidemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-6ffdnx	Alternatives schedules against hepatitis b in homeless person in Goias	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1830	Randomized clinical trial of alternatives schedules against hepatitis b and serum epidemiological study of syphilis and caused infections human immunodeficiency virus and viral hepatitis in homeless person in Goias	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Enfermagem Universidade Federal de Goiás	Faculdade de Enfermagem Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6ffdnx	<NULL>	Man aged 18 years or over; who have lived in a street situation for at least 30 days; who are in the place of data collection for a maximum of 30 consecutive days and who are susceptible to the hepatitis B virus.	Man with confirmed serological diagnosis of HIV; with some contraindication of the vaccine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-35jq4c	Responses of physical training on the metabolism and body fat of adolescents.	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	1831	Influence of B2 polymorphism on basal metabolism and pulmonary function in asthmatic and non-asthmatic obese subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Departamento de Educação Física (DEF), da Universidade Federal do Paraná (UFPR)	Faculdade de Educação Física da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35jq4c	<NULL>	"Conditions to participate in all evaluations
and / or intervention; presentation of the informed consent form (TCLE) and free and informed consent form (TALE) signed; individuals of both sexes between, 13 and 17 years of age; pubertal staging Tanner IV; individuals classified as eutrophic (BMI &lt;z-score +1) or overweight (BMI z-score +1);
not presenting clinical conditions such as: established diagnosis of type 1 or type 2 diabetes, familial dyslipidemia and / or treatment with statins, Untreated or uncontrolled hypothyroidism / hyperthyroidism; obesity induced by other endocrine disorders, delayed significant puberty of any etiology requiring investigation and / or treatment,
patients with a diagnosis or suspicion of growth hormone deficiency, severe asthma requiring frequent hospitalizations or use of systemic corticosteroids for more than 10 days, a history of current treatment or treatment with medications that may cause significant weight gain within three months prior to the screening visit, including corticosteroids (bariatric surgery less than 7-10 days), tricyclic antidepressants, antipsychotics and mood stabilizers, previous surgical treatment for obesity (Bariatric Surgery), known or suspected alcohol, drug or narcotic abuse, recent infections or the presence of acute inflammatory disease or chronic, genetic syndromes that lead to obesity."	To present some intercurrence that would make continuity of the intervention and / or evaluations impossible; participation in other activities that interfered in the results of the research such as (sports practice or systematic exercise, diets, other treatments); less than 70%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-22kxyc	Results of a program involving adequacy of wheelchair posture in the quality of life, satisfaction and activities of caregivers of children with cerebral palsy	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1832	Effects of postural adequacy on satisfaction, quality of life and occupations of caregivers of children with cerebral palsy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-02	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-22kxyc	<NULL>	Caregivers who accompany adolescents with clinical diagnosis of cerebral palsy for at least one year and who do not receive remuneration for care; adolescents who are aged between 10 and 19 years and who use wheelchairs in a home environment for at least one year.	Adolescents with cerebral palsy who have already undergone postural adjustments through the use of the digitized system; who are able to use the wheelchair independently, requiring no direct assistance from a caregiver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-7pcn85	Gait analysis in patients with Parkinson&apos;s Disease before and after a training program in a real and virtual environment	Recruitment completed	Intervention	2018-05-22	<NULL>	<NULL>	1833	Three-dimensional gait analysis in patients with Parkinson&apos;s Disease before and after a training program in a real and virtual environment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-7pcn85	<NULL>	"Patients diagnosed with Parkinson&apos;s disease; Age 60-80 years;
Patients able to walk more than 10 feet in a straight line; Patients treated with medication; Visual and auditory acuity good."	Volunteers with previous orthopedic surgeries; with other neurological diseases; diabetes mellitus uncontrolled; hypertension uncontrolled; uncontrolled heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8v7qhq	Effect of functional foods on Metabolic Syndrome	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1834	Effect of nutraceuticals on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal do Estado do Rio de Janeiro	Escola Nacional de Saúde Pública/FioCruz	https://ensaiosclinicos.gov.br/rg/RBR-8v7qhq	<NULL>	Subjects aged 18 or older; carrying Metabolic Syndrome criteria according to the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP ATPIII 2001); who consented formally to join the study	Those who had diagnostic for thyroid abnormalities; hepatic ou renal failure; under treatment for corticoids; hipolipemiant drugs or low calorie diet on the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8ysb3n	Evaluation of the Physiotherapy with Cycle Ergometer in the Funcional Recovery after Cardiac Surgery	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1835	Cycle Ergometer and Conventional Physiotherapy in patients submitted the Cardiac Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-31	Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-8ysb3n	<NULL>	Patients of both sexes; aged 18 or older; admitted to the ICU and underwent coronary artery bypass graft surgery and / or valve replacement.	Patients with change of the level of consciousness; motor- or neurological impairment; with persistent hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-354q7d	Comparison between two types of bone graft in post-extraction teeth: non-inferiority clinical trial	Recruitment completed	Intervention	2018-05-22	<NULL>	<NULL>	1836	Comparison between two bone substitutes in post-extraction sites: non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-354q7d	<NULL>	Need of anterior maxillary extraction; systematically healthy patients; signed by the Free and Informed Consent Form	Pregnant or lactating women; carriers of metabolic diseases; use of bisphosphonates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-9zqwhv	Psychological problems and hand function in children and adolescents with kidney disease undergoing Hemodialysis treatment	Data analysis completed	Observational	2018-05-22	<NULL>	<NULL>	1837	Psychological and functional alterations in adolescents with Chronic Renal Disease dependent on hemodialysis in initial and advanced treatment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9zqwhv	<NULL>	"Children and adolescents aged 9 to 19 years, the control group was paired with respect to gender and age;
For the sample, children and adolescents diagnosed with CKD, and dependent on hemodialysis treatment;
Signature of the Informed Consent Term (TCLE) and the Informed Consent Term (TALE), both for the group of patients and for the control group;"	"Children and adolescents with inability to understand the objectives of the study, as well as the issues presented;
Severe auditory or verbal impairment, making it impossible to understand the tests and objectives of the study;
Medical contraindication for participation;
Severe neuropsychiatric comorbidity associated."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-63w5nz	Comparing the effect of two different movements systems on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-22	<NULL>	<NULL>	1838	The incidence of postoperative pain after using a reciprocating system and a continuous rotary system: A prospective randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-63w5nz	<NULL>	Patient with physical status classified as ASA I (without systemic disorders) or II (with discrete to moderate systemic disorders) (American Society of Anesthesiologist / ASA); permanent teeth that require the need for endodontic treatment; presence or absence of periapical lesion; absence of symptomatology in the tooth to be treated; male and female gender; ages between 9 and 90 years; teeth with pulpal diagnosis: normal pulp, reversible pulpitis, asymptomatic irreversible pulpitis or pulp necrosis; teeth with apical diagnosis: normal apical tissue and with asymptomatic apical periodontitis	Pregnant patient; teeth with cracks or root fractures; patients who took pre-operative analgesic medication (in the last 24 hours), steroidal or non-steroidal anti-inflammatory and antibiotic (in the last 180 days); patients with periodontal disease; non-endodontic origin periapical lesion; previously accessed teeth; pre-filled teeth; teeth that need retreatment; teeth with pain palpation; teeth with vertical and / or horizontal pain percussion; teeth with spontaneous pain; teeth with mobility grade 2; internal or external resorption; teeth with incomplete rhizogenesis; apical obstruction of the root foramen	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8w9dbt	Effect of Acupuncture before Wisdom tooth extraction that is not yet born	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1839	Effect of Energetic Regulation with Acupuncture in molar third-party exodontia surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-23	Faculdade de Odontologia da Universidade Estadual de Campinas	Faculdade de Odontologia da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8w9dbt	<NULL>	Volunteers both genres; age between 18 and 30 years; with good general health; with four third molar teeth being the two lower molars included or semi-included with the same anatomical position	Volunteers with lower molars in antagonistic anatomical positions; weakened general health; clinical history of previous infection; carriers of severe emotional disorders; The energy level balanced between the normal range of 40 to 60	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-5jznnt	Comparison of the results obtained in the exam that evaluates the functioning of the bladder with the clinical examination to try to find out if there is difficulty for women to urinate if they have a low bladder or other gynecological diseases	Recruiting	Observational	2018-05-23	<NULL>	<NULL>	1840	Comparison of the results obtained in the urodynamic exam in the flow / pressure study phase with urethral resistance analysis (free flowmetry, maximum detrusor pressure at maximum peak urinary flow and post void residue), with the classification of POP-Q (Pelvic Organism Prolapse Qualification), for the dystopias pelvicase with the quality of life questionnaire, validated for the Portuguese language, to standardize the diagnosis of infravesical obstruction in patients with Urinary Incontinence associated w	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Universidade Federal de São Paulo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-5jznnt	<NULL>	Patients with low urinary complaints.Patients who underwent the Urodynamic Study.Patients who signed the Informed Consent Form.	Patients with urinary infection at the time of the urodynamic study.Patients with Neurogenic Bladder.Patients who refused to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-7hpfwj	The effect of Therapeutic light on the control of Dental pain during and after Bleaching performed in a dental office	Recruitment completed	Intervention	2018-05-23	<NULL>	<NULL>	1841	The effect of Phototherapy on the Dental sensitivity during and after tooth whitening with Hydrogen peroxide at 35%	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-19	Programa de Pós-Graduação em Odontologia Integrada da Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-7hpfwj	<NULL>	Have a voluntary interest in undergoing aesthetic treatment for teeth whitening; be between 18 and 30 years old, regardless of gender; presenting from the first to the first molar, in the upper and lower arches, healthy, without lesion of caries and / or restoration on either side; present the teeth with initial color B2 or darker, according to the Vita Classic scale (Vita Lumin, Vita Zahnfabrik, Bad Sackingen, Germany); present oral health (absence of lesion or any type of suggestive alteration of pathology); good oral hygiene and periodontal health.	People who have already had dental bleaching; self-reported dental sensitivities (spontaneous and / or provoked, have healthy teeth with severe color changes that can not be corrected with dental bleaching, are under medical treatment or use controlled medication, have any type of systemic alteration; history of sensitivity to hydrogen peroxide, present recessions of the gingival tissue and exposure of the dentinal tissue in the cervical region, present parafunctional habits and painful symptomatology of the temporomandibular joint (TMJ), being smoker, presenting any type of pathological alteration in the oral cavity; use of orthodontic appliance or dental prosthesis, if female, be pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-63ctjw	Influence of reduction of standard preoperative fasting time and that added with protein in patients with head and neck cancer	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1842	Influence of the standard preoperative fasting and added with protein in patients with head and neck cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Instituto Nacional de Câncer	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-63ctjw	<NULL>	All patients who are candidates for elective surgeries; who are 19 years of age or older; and consent to participate in the study through the signing of the Informed Consent Form.	Volunteers inability to receive oral feeding in the preoperative period; without adherence to any of the phases of the study protocol; in use of prophylactic antiemetics 24 hours before surgery and in the immediate postoperative period; with previous diagnosis of diabetes mellitus, chronic kidney disease and / or liver disease, obesity (WHO, 2000); with presence of gastroesophageal reflux; intestinal obstruction and cases of gastroparesis and / or pyloric stenosis and surgeries with low nutritional impact (base of skull, maxillary sinuses, thyroid gland, parotid glands, cutaneous and ocular).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-4zzc3p	Comparison of a local anesthetic technique applied by syringe or by computer	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1843	Comparative study of length and duration of Inferior Alveolar Nerve Block with Lidocaine 2% + Epinephrine 1: 100.000 applied by conventional technique or computerized system	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4zzc3p	<NULL>	Volunteers aged between 18 and 35 years; who have not undergone blockade anesthesia in the region in the two weeks prior to the study; present 02 lower molars in need of restorative treatment; not having used any medication that could alter the perception of pain in the two weeks prior to the study.	Hypersensitivity to drugs used in the study - 2% Lidocaine with epinephrine 1: 100,000; Benzocaine 20%; presence of organ dysfunction or clinically significant deviation from normal, assessed during anamnesis; odontophobic; pregnant and / or lactating women; history of drug addiction or alcohol abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-35tnj7	Effect of laser therapy on clinical and subjective aspects in implant placement: A randomized clinical trial	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1844	Influence of low level laser therapy on clinical and subjective aspects in dental implant placement: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-35tnj7	<NULL>	To be included in the sample the patients should need for extraction of any teeth due to root crack/fracture or perforation with indication of immediate implant installation; good general health, which allow the tooth extracion and implant installation procedures; time availability to attend the follow-up appointments.	Patients presenting poor general health that prevents the accomplishment of the surgery for installation of dental implant; and patients who do not have available hours to attend for dental treatment and follow-up appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-882rg2	The role of nurses in relation to nursing protocols for better care of patients in the emergency room in Brazil	Not yet recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1845	Nurses&apos; knowledge and practices in the face of the challenge of using the systematization of nursing care as an instrument of assistance in a first aid in Brazil	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-882rg2	<NULL>	Nurses filled in the Hospital; Minimum six months experience in the service	Professionals on vacation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-3p7wsr	Effects of interactive games on brain activation and quality of life of individuals with spinal cord injury	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1846	Effects of Virtual Reality on brain activation and quality of life of individuals with Spinal Cord Injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-30	Universidade de Franca	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3p7wsr	<NULL>	participants of both sexes; age between twenty and fifty years; clinical diagnosis of complete and / or incomplete spinal cord injury; at least one year of injury; be able to tolerate static posture for at least five minutes without minimal assistance; agree to discontinue the traditional treatment of physical therapy during the period of data collection.	Participants with significant orthopedic injuries that could limit seated posture, such as severe contractures or cutaneous lesions in the lower limbs; presenting spinal stabilization devices that limit mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury, eg, stroke, which may interfere with the performance of mental practice; medical diagnosis of dementia diseases such as Alzheimer&apos;s Disease, Vascular Dementia, Mixed Dementia, Lewy Body Dementia, Frontotemporal Dementia; clinical diagnosis of depression; use of antidepressant medications; cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-9d5n4g	clinical trial for evaluation of Tooth Whitening in different application techniques	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1847	Combined, At-home and In-Office Dental Bleaching: efficacy, clinical parameters follow-up and enamel evaluation of calcium and phosphorus concentrations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Faculdade Centro de Pesquisa São Leopoldo Mandic	Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-9d5n4g	<NULL>	Inclusion criteria: aged 18 to 30 years, the presence of at least 20 teeth and the presence of the elements 11, 21, 22, 12, 13, 23, 31, 32, 33, 41, 42, 43 healthy or at most 1 / 6 restored labial surface.	The exclusion criteria of this study are: teeth with initial color B1 assessed by spectrophotometer (VITA Easyshade® Advance, Vita, Germany), patients with removable dentures or fixed and removable orthodontic appliances participants pregnant or breastfeeding, smoking participants, participants with prior dentinal sensitivity, presence of active caries lesions in enamel and dentin, periodontal disease and other oral lesions, pigmented teeth tetracycline and patients who received prior bleaching treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-9w92fv	Effects of Auricular Therapy in the treatment of Premenstrual Syndrome	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1848	Effects of Auricular Therapy in the treatment of women with symptoms of Premenstrual Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9w92fv	<NULL>	WWomen aged 18-35 years; sedentary; university students enrolled regularly at the Federal University of Paraná; and who have Premenstrual Syndrome (mild to moderate) or Pre-Menstrual Dysphoric Disorder according to the criteria listed in the PSST (Premenstrual Syndrome Screening Tool)	Women classified by PSST as mild or absent Premenstrual Syndrome; in the gestational period; with irregular menstrual cycles (cycles less than 25 days or greater than 35 days); women diagnosed with secondary dysmenorrhea (fibroids, endometriosis or cysts); who have a history of abortion; cardiopathy; who use antidepressants and / or psychotropic medication in the last two months; and, that they have any type of lesion in the auricular pavilion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-9tsmpp	Acupuncture associated with electrotherapy and running in the decreased localized fat	Recruitment completed	Intervention	2018-05-25	<NULL>	<NULL>	1849	Acupoint electropolysis and aerobic activity in the reduction of localized adiposity in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-9tsmpp	<NULL>	University students; women; age between 18 and 30 years; White breed; been sedentary for two months; presence of abdominal adiposity and flank region; Body Mass Index classified as normal or overweight	Women in dermatological-functional treatment to reduce localized adiposity; patients with cardiac, respiratory, diabetes mellitus, systemic arterial hypertension and neoplasias; patients unable to provide sensitive feedback or with changes in cutaneous sensitivity; aversion or allergy to the use of electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-64wrvv	Physical Therapy for Sexual Dysfunctions Caused by the Treatment of Cervical Cancer	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1850	Physical Therapy in Sexual Dysfunctions from the Treatment of Cervical Cancer in a Public Hospital in Belém do Pará	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade do Estado do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-64wrvv	<NULL>	Women aged between 35 and 65 years; women diagnosed with cervical cancer, women who underwent pelvic radiotherapy by teletherapy or brachytherapy with or without surgery, women who agree to participate in the study by signing the informed consent form	Women with diabetes; with hyperprolactinemia, with hypothyroidism; with any other condition that may alter the results of the present study; those who refuse to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-2g5yx5	Clinical simulation in teaching to undergraduate nursing in wound assessment	Recruitment completed	Intervention	2018-05-25	<NULL>	<NULL>	1851	Clinical simulation in teaching-learning process to undergraduate nursing in wound assessment: randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2g5yx5	<NULL>	Second year undergraduate nursing students	Exchange students who have had experience with a course or training in wounds using clinical simulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-748nrs	Repetitive transcranial magnetic stimulation for tinnitus treatment	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1852	Effects of repetitive Transcranial Magnetic Stimulation on chronic tinnitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-03	Instituto de Psiquiatria Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-748nrs	<NULL>	Age between 18 and 75 years of age. Presence of tinnitus between 6 months and 5 years. Moderate to catastrophic annoyance with tinnitus measured by the Tinnitus Handicap Inventory. Normal hearing test or sensorineural hearing loss compatible with age.	"Objective tinnitus. Incapability to answer the scales and questionnaires. Neurologic or cognitive diseases. External or middle ear disease.
Tinnitus with specific treament of the basic cause as thyroid hormones, somatossensory tinnitus. Use of pacemakers or metallic components in the head and neck region. Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-29rzdh	Impact assessment of Criança Feliz Program and Book Loans&apos; Program	Not yet recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1853	Impact assessment of Household Visits and Book Loans	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-21	IDados Estudos Pesquisa e Informação	IDados Estudos Pesquisa e Informação	https://ensaiosclinicos.gov.br/rg/RBR-29rzdh	<NULL>	Families with children under 3 years old; families with pregnant women.	There are no exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-759bvb	Analysis on the maintenance of the bone around the implants with threads in their neck. Study in humans.	Not yet recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1854	Evaluation of the remodeling of bone crest and marginal bone around implants with cervical microthreads. Clinical study in humans.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Centro Universitário de Araraquara	Centro Universitário de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-759bvb	<NULL>	To be included in the study, the patient should present at least two edentulous areas with a minimum healing period of 3 months post-extraction and without the need for reconstructive therapies. These patients should have good periodontal condition and good general health status.	The exclusion criteria will be: need for prior tissue reconstruction, smokers, alcohol users, drug users, uncontrolled diabetics, oral or intravenous bisphosphonate therapy, bruxism or parafunction patients, or patients with systemic diseases that are known to interfere osseointegration of the implants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-6qr863	Use of denture adhesive in the period of adaptation with new complete dentures in patients with normal and resorbed ridges	Recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1855	Use of denture adhesive in the period of adaptation with new complete dentures in patients with normal and resorbed ridges	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-22	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6qr863	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years; both genders; users of conventional complete dentures; requiring replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva; no previous experience of denture adhesive; new dentures considered satisfactory	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-2jxgm2	Manufacture of single crowns on implants through angled abutments	Not yet recruiting	Intervention	2018-05-29	<NULL>	<NULL>	1856	Angled titanium base abutments for the reconstruction of anterior implants with screw-retained single crowns: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jxgm2	<NULL>	At least 18 years; Missing tooth in the anterior maxilla; Need for a single implant crown; Presence of one adjacent tooth at the implant site; Presence of antagonist; Adequate oral hygiene; Capability to comply with the study procedures; Signed Informed Consent Form	Ridge preservation procedure after tooth extraction performed; Pregnant or lactating women; Known or suspected non-compliance, drug or alcohol abuse; Smokers (more than 10 cigarettes/day); Currently taking drugs that influence bone metabolism; Use of bisphosphonates in the last 4 years; History of malignancy, radiotherapy or chemotherapy for malignancy in the past 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-78zr5h	The effect of Educational Intervention on self-care of the elderly with Diabetes	Data analysis completed	Intervention	2018-05-29	<NULL>	<NULL>	1857	Effect of Educational Intervention to foot self-care of the elderly with Diabetes Mellitus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-78zr5h	<NULL>	Minimum age of sixty years; diagnosis of Diabetes Mellitus; Being monitored at the basic health unit.	Impossibility to walk to the health unit; impairment of speech and vision.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-4chsdr	Study of aquatic physiotherapy in women after surgery for breast cancer	Data analysis completed	Intervention	2018-05-30	<NULL>	<NULL>	1858	Evaluation of the performance, efficacy and safety of aquatic physiotherapy in the rehabilitation of shoulder movements in women submitted to surgical treatment of breast cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Brazilian Mastology Research Network	Brazilian Mastology Research Network	https://ensaiosclinicos.gov.br/rg/RBR-4chsdr	<NULL>	"Females were included between the 7th and 20th postoperative days of mastectomy or quadrantectomy associated with axillary lymphadenectomy at levels I, II and III of Berg; 
who were regularly followed up at the services proposed for the study."	The exclusion criteria were: to present lymphedema in the homolateral upper limb before and/or after surgery, open wounds and presence of infection at the surgery site, presence of drains and/or probes, as well as clinical pathologies in activity, such as heart failure, visual impairment, and faecal or urinary incontinence. Also excluded were women with orthopedic changes in the shoulder joint, such as impact syndrome and rotator cuff tendinopathy. Exclusion criteria related to breast cancer included metastatic disease, sentinel lymph node biopsy, immediate post-mastectomy breast reconstruction, and peitoral muscle resection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-248x3v	Physical Activity and Sleep Hygiene as a treatment of Depression in the elderly	Data analysis completed	Intervention	2018-05-30	<NULL>	<NULL>	1859	Physical Activity and Sleep Hygiene: frequently neglected aspects in the treatment of Depression in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-10	Universidade Federal de Minas Gerais	Ambulatório de Neuropsiquiatria Geriátrica, Hospital Borges da Costa, Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-248x3v	<NULL>	Age above 60 years; both sexes; under medication treatment of the depressive disorder; complaints of sleep disorders.	Hemodynamic instability; severe cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-7ncggq	Evaluation of Pain after Knee Surgery using Pregabalin before and after Surgery	Recruiting	Intervention	2018-05-30	<NULL>	<NULL>	1860	Postoperative Pain analysis with perioperative administration of Pregabalin in patients submitted to Knee Arthroscopy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Hospital São Domingos	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-7ncggq	<NULL>	"Patients diagnosed with chronic knee instability; patients older than 18 years; physical status classification according to the scale of the American Society of Anesthesiologists (ASA) I and II;
without local and systemic inflammatory diseases; isolated lesions of the anterior cruciate ligament (no other knee ligaments);
no history of fractures in the knee region;
absence of previous surgeries in the knee region; operated by the orthopedist of the team;
ability to read, understand and agree to the inclusion of your data
in this research."	"Skeletally immature patients; chondral lesions greater than 2 cm2; associated surgical procedures, such as osteotomies, and other knee ligaments; neurological, muscular, rheumatologic, neoplastic or infectious diseases that could provoke some type of joint involvement (gout, multiple myeloma,
psoriasis, lymphoma, Paget&apos;s disease, rheumatoid arthritis, chronic renal failure,
osteomyelitis, ankylosing spondylitis, systemic lupus erythematosus); patients without clinical conditions, hypertensive, with coagulopathies, pregnant women; chronic use of anticoagulants; use of analgesics up to 24 h before the surgical procedure; patients who refused to sign the EHIC; patients not operated at the São Domingos Hospital; refusal or impossibility of the patient to perform the postoperative rehabilitation; non-acceptance of the anesthesiologist in following the protocol of the project; patients allergic to the medications used in the protocol; patients who declared themselves indigenous."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-858qxn	Comparation between the techniques of Extubation in the Surgical Block and the Intensive Care Unit on the regional lung ventilation assessed by Electric Impedance Tomography in patients undergoing Noninvasive Ventilation following  Heart Surgery: a cross-sectional study	Recruiting	Observational	2018-05-30	<NULL>	<NULL>	1861	Comparation of Ultra-Fast-Track and Fast-Track techniques in the regional lung ventilation assessed by Electrical Impedance Tomography in patient undergoing prophylactic nasal positve airway pressure following Cardiac Surgery: a cross-sectional study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858qxn	<NULL>	Ages between 18 and 65 years; body mass index  between 18.5 and 30 kgm2; undergo the Ultra Fast Track and Fast Track extubation techniques; without chronic obstructive pulmonary disease; pulmonary fibrosis; or chronic renal failure; or associated neuromuscular diseases; and those who have an American Society of Anesthesiologists perioperative risk score of less than 4.	Liver failure; congestive heart failure; dementia and Alsheimer&apos;s disease; left ventricular ejection fraction less than 40%; anticonvulsant; antidepressant; psychoactive drug in use and emergency reoperated patients; high surgical risk according to EuroSCORE II; presente cardiopulmonary bypass time great than 120 minutes; bleeding with thoracic drainage great than 100 mLh; renal failure with urine output less than 0.5 mLh in the first 6 hours; increased serum creatinine level less than 50% the baseline; prolonged inotropic and vasodilatory drugs support due to cardiac problems; extubation failure for hypercapnia; more than a failure in the autonomic test; mechanic ventilation assist time greater than 6 hours; hemodynamic instability; cardiogenic shock; severe hypotension with systolic blood pressure less than 90 mmHg; episode abdominal distress; nausea and vomiting; depressed level of consciousness; use of accessory muscle; respiratory rate great than 35 ipm; hypoxemia with PaO2 less than 50 mmHg with FiO2 of 50% or hypercapnia with PaCO2 great than 55 mmHg and with pH less than 7.30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3wn6tf	Effect of physical and mental training, involving two tasks together, on the functionality of the elderly	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1862	Efect of motor-cognitive training (double task) in the functionality of elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal Do Triângulo Mineiro	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3wn6tf	<NULL>	Minimum score of 18 points in the Mini-Mental State Examination (MMSE); be literate; presenting visual acuity preserved or corrected	"Inability to maintain orthostatism and to wander without the use of any auxiliary gait device; those who are submitted to another type of physiotherapeutic intervention concomitantly; participants during the study period: changes such as significant or chronic orthopedic pain, joint deformities,
three consecutive service sessions, any of the non-inclusion characteristics already mentioned"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-8shb3h	Effects of Muscular Massage with Instruments on the operation of the heart of young women practicing weight training	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1863	Effects of Instrumental Myofascial Release on cardiac autonomic modulation in young women practicing weight training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Centro Universitário de Formiga - Minas Gerais	Centro Universitário de Formiga - Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8shb3h	<NULL>	40 young women; age between 18 and 24 years; exercise bodybuilding at least three times a week for a minimum of six uninterrupted months; present vital signs such as blood pressure, heart rate, oxygen saturation and respiratory rate within the normality patterns at the time of data collection; resting heart rate between 50 and 80 beats per minute (bpm); agree and sign the Informed Consent Form	Chronic obstructive pulmonary disease; Diabetes Mellitus; Arterial hypertension; Thyroid diseases; Heart diseases; patients with pacemakers; users of medications Diuretics and Beta-blockers; obese individuals; dermatological problems; skin lesions; edema; changes in blood coagulation; vascular hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-94dhdy	Association of a Phosphorus Counting Table with Sevelamer for control of blood level of phosphorus in hemodialysis patients	Data analysis completed	Intervention	2018-05-31	<NULL>	<NULL>	1864	Association of a Phosphorus Counting Table with Sevelamer Hydrochloride for control of hyperphosphatemia in hemodialysis patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-03	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94dhdy	<NULL>	Patients on hemodialysis for at least 6 months and who underwent a dialysis regimen at three times a week with a duration of four hours per session; age range greater than or equal to 18 years; literate or had literate carer; phosphate binder use for at least 12 weeks; parathyroid hormone less than 800pg/mL; signed the written informed consent form	Patients who missed more than one hemodialysis session per month; patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases; patients with indication of use of calcium carbonate as phosphate binder and who had no indication of sevelamer hydrochloride use; hypophosphatemic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4gzj9m	Effect of Gluten Consumption on pain sensitivity of women with Temporomandibular Dysfunction	Recruiting	Intervention	2018-06-02	<NULL>	<NULL>	1865	Influence of Gluten Intake on mechanical somatosensory mechanisms of women with Myofascial Pain of the Masticatory Musculature	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4gzj9m	<NULL>	Women. 20 to 45 years. Myofascial Pain in Masticatory Musculature for at least 3 months. Pain rating of at least 5.	Toothache. Fibromyalgia. Primary Headache. Diabetes uncontrolled. Uncontrolled hypertension. Lupus. Leprosy. Multiple sclerosis. Hypothyroidism. Carpal tunnel syndrome. Intracranial hypertension. Pregnancy. Previously diagnosed disabling psychological and neurological changes. Chikungunya fever. Dieting restrictive. Present signs and symptoms of intolerance, sensitivity or allergy to gluten. They should not have been treated for TMD in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-7rh8y2	Study of three types of treatment for leg ulcers of people with problems arising from leprosy	Recruitment completed	Intervention	2018-06-02	<NULL>	<NULL>	1866	Zinc oxide versus hydrogel ointment in the treatment of chronic ulcer in people with leprosy sequelae: a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-26	Faculdade de Medicina de Botucatu UNESP	Instituto Lauro de Souza Lima	https://ensaiosclinicos.gov.br/rg/RBR-7rh8y2	<NULL>	Have treatment completed for leprosy confirmed in the medical record by ICD A30; have leg ulcer; both genres; Age between 18 and 90 years	Use of systemic antimicrobials; infected or critically colonized ulcers that present evidence of an infectious process.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3m45y3	Effect of Acupuncture to control Diabetes.	Recruitment completed	Intervention	2018-06-04	<NULL>	<NULL>	1867	A randomized controlled trial evaluating the effect of acupuncture on type 2 diabetes using the FreeStyle libre® system.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-3m45y3	<NULL>	Research participants should be able to clearly understand and cooperate with all the procedures described in the Study Consent Form, including completing the questionnaires. Men and women between the ages of 20 and 75; Patients with type 2 diabetes for at least 3 years with stable glycemic control; verified by the A1c dosage in the last 3 months without change of medication.	"Use of synthetic glucocorticoids * such as prednisone, prednisolone, methylprednisolone and hydrocortisone by oral or topical routes.
Pregnancy; Type 1 Diabetes; Antecedents or suspected nephrotic syndrome, hepatic insufficiency, hyperthyroidism, acromegaly, renal failure; Use of insulin to treat diabetes"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9z95r5	Traumatic stress: Prevalence and Intervention in Groups Exposed to Critical Incidents	Not yet recruiting	Intervention	2018-06-04	<NULL>	<NULL>	1868	PTSD: Prevalence and Assessment of an Intervention in Groups Exposed to Critical Incidents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Programa de Pós-Graduação em Psicologia da Universidade Federal de Santa Catarina	Corpo de Bombeiros Militar de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9z95r5	<NULL>	Volunteers belonging to a group exposed to critical incidents; 18 year or above; clinical or subclinical level of posttraumatic stress disorder	Volunteers who have suffered multiple-incident childhood trauma; volunteers who have previously been diagnosed with mental disorders other than posttraumatic stress disorder, acute stress disorder, or depression- or anxiety-related disorders; volunteers who have received medical, psychiatric or psychological treatment for traumatic stress disorders, depression or anxiety in the year preceding the trail; volunteers who are presently receiving medical, psychiatric or psychological treatment for mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-243frc	Evaluation of the ruler with measurements of the cervix as a learning resource	Not yet recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1869	Evaluation of the indicator of cervical dilatation as a didactic instrument	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-243frc	<NULL>	To belong to the course of Obstetrics of the School of Arts, Sciences and Humanities of the University of São Paulo; be regularly enrolled in the 5th or 7th semester; not having completed the course Integrated Curricular Internship III (Assistance in childbirth and birth)	Have experience of the vaginal touch on the manikin; no agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3rh38g	Variability biomarkers of individual responses of the Cariorespiratory Fitness to aerobic training	Recruitment completed	Intervention	2018-06-05	<NULL>	<NULL>	1870	Responsivity biomarkers of Cariorespiratory Fitness to aerobic training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Educação Física da Universidade Estadual de Campinas	Laboratório Nacional de Biociências - LNBio	https://ensaiosclinicos.gov.br/rg/RBR-3rh38g	<NULL>	Young sedentary healthy men; age between 18-30 years old	Smokers; hypertensive with systolic blood pressure higher than 140 and diastolic blood pressure higher than 90 mm Hg; diabetic with fasting glucose higher than 7.0 mmol L-1; severe obese defined defined as body mass index higher than 33 kg m-2; dyslipidemic based on medication; com evidence of heart diseases; metabolic disorders; significant chronic respiratory conditions or musculoskeletal problems interfering with exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-6frnzp	Effects of prolonged exercise on metabolic changes in insulin, inflammation and oxidation in morbidly obese subjects	Recruitment completed	Intervention	2018-06-05	<NULL>	<NULL>	1871	Effects of chronic physical exercise of moderate intensity on insulin signaling pathways, inflammation and oxidative stress in individuals with morbid obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6frnzp	<NULL>	Adults between 18 and 60 years of both sexes; availability and physical conditions to perform the tests and supervised physical exercises (control group and obese subjects submitted to physical exercise); availability to perform dietary restriction and physical inactivity (obese group submitted only to the restrictive diet) during the study period; inactive for at least 30 days (less than 150 minutes of moderate physical activity per week); no restrictive diet in the last 30 days; no use of medications for weight loss or modulation of body composition for at least 3 months; stable weight at least 3 months	Individuals with or having a first-degree history of cardiovascular diseas; hepatic impairmen; renal impairment; diabetes; thyroid disorders; menopausal women; pregnant women; nursing mothers; smokers; or in continuous use of any medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-2qpdw4	Bloog glicose control following surgery and the ocurrence of Infection on the surgical site among Liver Transplantation recipients	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1872	Postoperative Blood Glucose Control vs. Surgical Site Infection incidence among Liver Transplantation recipients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Escola de Enfermagem da Universidade de São Paulo	Santa Casa de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-2qpdw4	<NULL>	"Liver transplantion recipients, age of 18 years or older.
Liver transplantation recipients whose allograft came from deceased donors."	"Liver transplantation recipients underwent any kind of surgery with or without prosthesis implant in the 30 days before the transplantation.
Liver transplantation recipients who will be submitted to multiple organ transplantation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9w9m83	Comparative analysis in implant-supported metal ceramic and hibrid ceramic crown	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1873	"Comparative analysis of Clinical and Molecular parameters in implant-supported Metal Ceramic and 
Hybrid Ceramic crowns"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9w9m83	<NULL>	Edentulous sites for replacement of unitary prostheses in the premolar or molar regions; bone height at least 8.5 mm; minimum cervical bone thickness of 5 mm; minimum age of 18 years; ASA I or ASA II patients; periodontally healthy adjacent teeth without previous treatment of chronic / aggressive periodontal disease and without the need for prosthetic restoration; healthy natural antagonist teeth (absence of restorations or prostheses) and periodontally healthy.	History of alcoholism; smokers; illicit drug users; cardiopathy; decompensated diabetics; complex rehabilitation needs (alteration of vertical dimension of occlusion, need for other rehabilitation procedures); lack of height and sufficient bone thickness; patients with parafunctional habits (bruxism); grafted areas;  irradiated patients; patients who underwent long-term steroid therapy or bisphosphonate users; periodontally compromised patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-6vg875	The effect of Environmental Light on Sleep and Level of Urinary Melatonin in women who gave birth	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1874	The effect of Environmental Light on Sleep and Level of Urinary Melatonin in Postpartum Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-11	Escola Paulista de Enfermagem  da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vg875	<NULL>	"Postpartum women: more than 18 years of age; having given birth to an only child; living together for at least 24 hours; being literate; not working at night in the last 3 years; not using illicit drugs during pregnancy; agreeing and signing the free and informed consent term.
Newborns: born of any type of birth; full term; by gestational age (DUM); chronological age greater than or equal to 24 hours; birth weight over 2000 grams; no malformations; female or male; and those who are mothers to agree and sign the informed consent form for participation of the neonate in the study."	Postpartum women who present any type of complication after delivery; newborn in phototherapy; with malformation; or postpartum women whose neonate is transferred to another unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-297fzx	Effectiveness of educational intervention in adherence to postoperative care of stomach reduction surgery	Recruitment completed	Intervention	2018-06-06	<NULL>	<NULL>	1875	Effectiveness of educational intervention in adherence to postoperative care in bariatric surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-297fzx	<NULL>	Patients enrolled in the obesity program of the study institution; experiencing immediate preoperative; literate.	Patients using the intragastric balloon; without time availability; without a landline or mobile phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4pdpjm	Treatment of varicose veins with laser and radio frequency - comparative study.	Data analysis completed	Intervention	2018-06-06	<NULL>	<NULL>	1876	Endovenous Treatment of saphenous Insufficiency - a comparative study between Radiofrequency and Endolaser 1470 nm	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4pdpjm	<NULL>	Patients older than 18 years; with symptomatic venous disease of the lower limbs; with bilateral great saphenous vein reflux.	Patients without clinical conditions to be submitted to the proposed treatment; on the use of anticoagulants or with a diagnosis of coagulation disorder; carriers of chronic or acute inflammatory disease; history of neoplasia; age greater than 70 years; women who are pregnant or intending to become pregnant; women in lactation; presence of signs of peripheral obstructive arterial disease (ankle-arm index&gt; 0.9); history of prior varicose vein surgery; presence of significant reflux in the external saphenous vein or perforating vein, by the DUS evaluation; presence of reflux in the deep venous system, signs of superficial thrombophlebitis and recent or old thrombosis in the deep venous system, by the DUS evaluation; with lymphedema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4g4sk8	Effects of intraarticular infiltration in  rheumatoid arthritis women´s knees	Recruiting	Intervention	2018-06-06	<NULL>	<NULL>	1877	Effects of Intraarticular Infiltration of Triamcinolone Hexacetonide in Rheumatoid Arthritis women´s knees on static, functional and inflammatory activity measurements: a randomized, controlled, blinded clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-01-24	Universidade Estadual Paulista - UNESP	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-4g4sk8	<NULL>	Diagnosis of RA according to the American College of Rheumatology (ACR) Classification Criteria of 1987 or Classification Criteria for RA 2010 of the ACR / EULAR; Age over 18 years; Female gender; Analog Visual Scale (EVA) of knee pain between 40 and 80 mm; EVA of knee edema between 40 and 80 mm; Be stable with drugs modifying the course of the disease in the last 3 months and / or oral corticosteroids in the last month; Presence of refractory knee injury in the last 3 months.	Injury and / or diseases symptomatic knee than RA; radiographic classification of Kellgren-Lawrence grade IV; Knee prosthesis in the target joint; prior realization of any IIAC in the last 6 months; Symptoms of systemic or local infection; reported hypersensitivity to the drug components or contraindication to the use thereof;Suspected or confirmed pregnancy; Physical therapy or other treatment in parallel to symptom in knee; Uncontrolled systemic arterial hypertension; Previous knee surgery to be evaluated; Skin lesions at the IIA site; Deficit vision or hearing or cognitive preventing the completion of the evaluations proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-6d9cd6	Functional and posture training in patients with inflammation of the plantar fascia	Recruiting	Intervention	2018-06-06	<NULL>	<NULL>	1878	Functional training and postural control in patients with plantar fasciitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6d9cd6	<NULL>	Medical diagnosis of plantar fasciitis and /or heel spur; duration of symptoms greater than four months; ages between 30 and 65 years	Spondyloarthritis; fat-pad atrophy; proximal plantar fibroma; history of previous surgery and lower limb trauma; musculoskeletal or neurological disease that may predispose to heel pain and decrease muscle strength; discrepancy greater than 1.5 cm between lower limbs; having undergone physiotherapeutic intervention for this lesion and/or Pilates exercises in the last six months; and body mass index (BMI) greater than or equal to 34.9	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9z6hx2	Clinical Assessment of Caries Restorations in the posterior tooth with bulk-fill resin	Data analysis completed	Intervention	2018-06-06	<NULL>	<NULL>	1879	Longitudinal Clinical Assessment of Class II Cavity Restorations Using Bulk-Fill Technique: A Randomized Clinical  Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9z6hx2	<NULL>	Necessity of two Class II restorations with composite resin for decayed teeth or the necessity of changing the restoration; teeth which can be fully isolated; presence of antagonist and adjacent tooth; and teeth with vital pulp; no pain; direct pulp capping and no history of hypersensitivity	Very extensive caries lesion; pulp exposure during caries removal or cavities with a high risk of exposure; allergies to the materials to be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-573pcm	Effects of training the muscles of inspiration and training the muscles of the center of the body in professional athletes	Data analysis completed	Intervention	2018-06-07	<NULL>	<NULL>	1880	"Effects of inspiratory muscle training and
core training in professional athletes"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-573pcm	<NULL>	Males; Being an athlete at competitive level for at least one year; Having aged 18 to 35 years	Use of medications that interfere on autonomic control;respiratory diseases;cardiovascular diseases; smoking;sports injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-4t6szp	The Impact of Dance as a Complementary Therapy on the Quality of Life of Oncologic Patients	Not yet recruiting	Intervention	2018-06-07	<NULL>	<NULL>	1881	Clinical Trial: The Impact of Dance as Adjuvant Therapy on the Quality of Life of Oncologic Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Associação de Combate ao Câncer em Goiás	Financiamento Próprio dos Pesquisadores	https://ensaiosclinicos.gov.br/rg/RBR-4t6szp	<NULL>	Women in cancer treatment at Hospital Araújo Jorge ACCG; residents of the state of Goiás; with medical authorization to participate in the project	Women who although they are in cancer treatment at Hospital Araújo Jorge ACCG do not have medical authorization to participate in the intervention. And men in cancer treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-3pkcb7	Relation among calcium and vitamin D intake during pregnancy with inflammation in the placenta and clinical parameters of the newborn of women with preeclampsia	Recruitment completed	Observational	2018-06-07	<NULL>	<NULL>	1882	The relationship of calcium and vitamin D intake with the placental inflammatory parameters and clinical state in newborn of women with Preeclampsia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-05-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3pkcb7	<NULL>	For preeclampsia group, puerperas with pre-eclampsia; with or without calcium and / or vitamin D supplementation; with or without associated comorbidities will be selected. In order to compose the control group; puerperas without preeclampsia; healthy; with or without calcium and / or vitamin D supplementation will be included	The non-inclusion criteria for the preeclampsia and control group are puerperium of multiple gestation; smoking and use of illicit drugs; fetal malformations and fetal death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-62p5rf	Comparison of the retraction of 3 Dermis Substitutes used to treat Burn Sequelae	Recruitment completed	Intervention	2018-06-12	<NULL>	<NULL>	1883	Prospective, randomized, controlled study of Burn Sequelae comparing late Retraction between three dermal matrices: Integra®, Matriderm® and Pelnac®	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	Hospital das Clínicas de Ribeirão Preto	Hospital das Clínicas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62p5rf	<NULL>	Patients from the burn outpatient clinic of the Burn Unit of the HCFMRP-USP who had some chronic burn como sequela associated with aesthetic impairment; functional restriction; unstable scars or Marjolin&apos;s ulcer (carcinomatous degeneration); with at least 1 year post-burn follow-up ; in which surgical correction with partial skin graft was indicated.	Patients who lost a more than 10% of the partial skin graft, or patients who had any restrictions on the use of dermal matrix (such as allergy to any component present in the product), were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-3rx7sr	Effect of electrical stimulation applied on the scalp associated with hip musculature training in women without complaints of urinary incontinence	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1884	Effect of transcranial direct current stimulation (TDCS) combined with pelvic floor muscle training on the contraction force of the pelvic floor muscles in healthy women – Protocol for a randomized, controlled, double-blind, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-23	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3rx7sr	<NULL>	Women who had vaginal deliveries age between eighteen and fifty-nine years; No complaint and diagnosis of urinary incontinence; evaluated by Pelvic Floor Impact Questionnaire PFIQ-seven; Sexually active	Women who present with bladder prolapse greater than or equal to two; which prevent the introduction of the vaginal catheter; In treatment with radiotherapy in the pelvic region; In treatment of urinary infection or other conditions in the pelvic region; Pregnant women; Have a pacemaker; That they present contraindications to the use of CTEC history of recurrent seizure; tumors or skin infection at the site of stimulation and metallic materials implanted in the brain; Who presented anesthesia or hyperesthesia at the point of application of the ECTS; Positive cut-off point for the Mini Mental State Examination MMSE lower than eleven points already corrected for schooling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-57nftj	Effect of an educational intervention on adherence to treatment for Syphilis in postpartum women and their partners	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1885	Impact of an educational intervention on the follow-up of postpartum women with Syphilis and their sexual partners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	UFG- Hospital das clínicas da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-57nftj	<NULL>	Minimum age of 18 years; 6 hours after delivery; Infection by Treponema pallidum in prenatal, childbirth, immediate pre-delivery and / or puerperium; Indication of treatment in the last 30 days before delivery or in the puerperium; Non-treponemal test (VDRL) reagent in any titration; Record of inadequate treatment for prenatal syphilis	Inability to answer questions on forms and questionnaire; To present a diagnosis of mental disorders recorded in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-68895k	Homeopathy on mental health care	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1886	Homeopathy on primary care mental health	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-07	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-68895k	<NULL>	Users of the Basic Health Unit Cidade Aracy (Sao Carlos - Sao Paulo/Brazil), who are on antidepressants; and/or benzodiazepines; without psychiatric follow-up in the 12 months prior to inclusion	Schizophrenia; bipolar and substance use disorders (except benzodiazepines and tobacco). A suicide attempt in the 12 months prior to inclusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-84qkkv	Correlation of Genetic Characteristics with Development of Specific Diseases in Patients with Familial Adenomatous Polyposis	Recruitment completed	Intervention	2018-06-13	<NULL>	<NULL>	1887	Genotype-Phenotype Correlation in Patients with Familial Adenomatous Polyposis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Fundação Pio XII	Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-84qkkv	<NULL>	Carriers of Classical Familial Adenomatous Polyposis Syndrome. Carriers of pathogenic germline variants in the APC gene.	"Familiar members tested to the  mutation in the APC gene not carrying APC gene-related mutation.
Patients carrying the mutation in the APC gene who are  not willing to undergo the protocol of screening tests for colonic and extra-colonic manifestations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-85qvn9	Older women with urinary loss: evaluation and treatment with Exercise and Physiotherapy	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1888	Older Women with Urinary Incontinence: evaluation and intervention through Physical Exercise and Physiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-85qvn9	<NULL>	Female volunteers, with 60 years or more, with symptoms of urinary leakage during activities with efforts, urinary loss objective above two grams in pad test and preserved cognitive function.	Current or recent (within 6 months) physical therapy intervention for symptoms of stress urinary incontinence, presence of urge UI, because causes neurological or urinary tract infection, have practiced strength training for the past 6 months and presence of diseases that constitute contraindications for performing weight training as decompensated hypertension, osteoarthritis progress, fibromyalgia and surgery, fractures or ligament ruptures recent disc protrusion advanced and advanced postural deviations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-329pyp	Performance of a Bulk-Fill composite in proximal restorations in primary molars	Recruitment completed	Intervention	2018-06-13	<NULL>	<NULL>	1889	Performance of a Bulk-Fill composite in class II cavities in primary molars - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal de Santa Maria/ Pró-Reitoria de Pós-Graduação	Rachel de Oliveira Rocha	https://ensaiosclinicos.gov.br/rg/RBR-329pyp	<NULL>	Have at least one occlusal-proximal lesion involving enamel and dentin; be in good health.	Tooth with irreversible pulpitis; tooth with pulp necrosis, internal pathological reabsorption; external pathological reabsorption; presence of another material in the cavity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-6dv5kj	Effects of respiratory muscle training on pulmonary and respiratory muscle function, cardiac function and function of individuals with Parkinson&apos;s disease	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1890	Effects of inspiratory muscle training on pulmonary and respiratory muscle function, autonomic heart function and functional capacity of individuals with Parkinson&apos;s disease: a controled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6dv5kj	<NULL>	"Individuals with idiopathic PD diagnosed previously by a neurologist physician;
Aged 50-65 years; 
Classified in stages I to III of the modified Hoehn and Yahr Scale; 
Ability to walk independently."	"History of chronic or acute non-controlled cardiovascular and respiratory diseases; 
Individuals with cognitive; 
Another neurological disease; 
Change of medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-9x3tkp	Evaluation of pelvic floor muscles in orthostatic and gynecological positions in women with urinary loss	Recruiting	Observational	2018-06-13	<NULL>	<NULL>	1891	Evaluation of the strength and function of pelvic floor muscles in women with stress urinary incontinence in the standing and supine positions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-9x3tkp	<NULL>	80 women with stress urinary incontinence; or mixed urinary incontinence with predominant stress symptoms; the diagnosis of the type of incontinence was based on clinical parameters and the pad test	Patients younger than 18 years and above 65 years; with predominance of urgency or urge-incontinence symptoms; chronic degenerative diseases; uncontrolled metabolic diseases; neurological or psychiatric disorder; who have participated in pelvic floor rehabilitation programs previously and/or pelvic floor surgeries, or who are performing another type of treatment for urinary incontinence; with presence of genital prolapse grades II, III and IV; incapable of voluntarily contracting the muscles of the pelvic floor; with a body mass index greater than 25 kg/cm2; and women who feel discomfort with the devices used to evaluate the pelvic floor muscles	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8m8cf2	The effect of the release of composite resin components on restoration to gingival tissue	Recruiting	Observational	2018-06-13	<NULL>	<NULL>	1892	Release of components of a resinous restorative system	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8m8cf2	<NULL>	Older than 18 years, systemically healthy, non-smoking, with good oral hygiene, with absence of irreversible pulpal alteration, with the presence of a non-carious cervical lesion (LCNCs) that needs to be restored, normal periodontium	With severe systemic alteration, in the use of antibiotics and anti-inflammatories in the last three months, with altered periodontium, non-smoking only, who have performed other restorations in the last 6 months, pregnant women and infants, periodontal sites that presented bleeding during crevicular fluid collection or sites that prevent adequate collection of clinical parameters	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8g2rjk	Daily Oral Hygiene in Inpatients in Cardiology Unit	Not yet recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1893	Daily Oral Hygiene in Inpatients in Cardiology Unit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8g2rjk	<NULL>	Be waiting for cardiac surgery; 40 years or older at the time of data collection; Be hospitalized more than one day at the cardiology unit; Be in good physical and mental condition to perform intraoral clinical examination	Use of immunosuppressive drugs or antibiotics; Have contraindications for treatment of another disease; Have had radiotherapy treatment near the head and neck region; Patients with a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-6xtnxb	The effect of the Cycle Ergometer in the Step Counts of patients after Cardiac Surgery	Recruitment completed	Intervention	2018-06-14	<NULL>	<NULL>	1894	Cycle Ergometer and Conventional Therapy in patients after Cardiac Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-6xtnxb	<NULL>	Included in the study were patients admitted to the cardiovascular intensive care unit undergoing coronary artery bypass graft surgery and valvular surgeries, electively, with median sternotomy; aged 18 years or over; of both genders.	We excluded from the study those with difficulty understanding the activities involved in the research, and / or motor / neurological impairment, with the impossibility of using the cycle ergometer or gait independently.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8y748j	The Sleep of wheelchair rugby athletes: Train, rest and competition	Data analysis completed	Observational	2018-06-14	<NULL>	<NULL>	1895	Perception analysis of sleep and its relationship with performance in athletes of wheelchair rugby, during different phases of training	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-20	Unversidade Estadual de Campinas	Universidade federal de minas gerais	https://ensaiosclinicos.gov.br/rg/RBR-8y748j	<NULL>	Wheelchair rugby athletes from the same team, they must have been enrolled in regional, national or international competitions	The atheletes must wear the actigraphy for seven consecutive days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-7gyntj	Use of resin sealant for caries prevention and treatment	Not yet recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1896	Caries prevention with the use of resinous materials: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal do Maranhão - UFMA	Fundação de Amparo a Pesquisa do Estado do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-7gyntj	<NULL>	Individuals between 9 and 14 years old; With the presence of at least two 2nd permanent molars in infraocclusion (eruption stages 2 and 3); (ICDAS 0,1, 2 and 3); with pulp vitality; free of restorations / sealants on either side of the tooth that will be treated	Pre-young people who present with periodontal disease; do not present systemic alterations; that report previous allergies to restorative materials; who do not wish to participate in the study or who are not authorized by the parents / guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-7cfdxm	Problemas de nutrição em meninos que tem a fraqueza muscular conhecida como distrofia muscular de duchenne.	Recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1897	Nutritional Intervention in Duchenne Muscular Dystrophy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Departamento de Nutrição	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7cfdxm	<NULL>	Children and adolescents up to 19 years and 8 months at the beginning of the research; confirmed diagnosis of Duchenne Muscular Dystrophy.	Boys who show signs of acute infection on the day of the evaluations; or who, during the study, are hospitalized; undergo surgery; or do not wish to continue participating in it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-3g22mg	Effect of video for grandparents in the promotion of breastfeeding	Not yet recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1898	Effect of the use of educational technology for grandparents in the promotion of breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3g22mg	<NULL>	Grandparents whose firstborn daughters or daughters-in-law are in the third trimester of pregnancy will be included and regularly perform prenatal consultations by registered nurses, who are literate and plan to breastfeed their babies.	Grandparents whose daughters, daughters-in-law or grandchildren present some condition known to contraindicate breastfeeding and those with risk pregnancies will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-8hxpvz	Physiotherapy in women&apos;s perineum diseases in basic health care	Recruitment completed	Intervention	2018-06-14	<NULL>	<NULL>	1899	Physiotherapy in dysfunction of the pelvic floor of women in primary health care	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-8hxpvz	<NULL>	Women from 18 to 80 years	Women who present some osteomioarticular dysfunction reported by the participants that make it impossible to perform the postures at the time of practical activities. Pregnant women or those that become during the time of the research will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-78tyjr	Perineal muscle strength, sexual intercourse, and involuntary urine loss	Recruiting	Observational	2018-06-14	<NULL>	<NULL>	1900	Correlation of muscle function of the pelvic floor with female sexual and urinary functions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-78tyjr	<NULL>	The research will be conducted with women who will be submitted to the PCCU (preventive), with a minimum age of 18 years and who are sexually active	Neurological problems, hypertension, diabetes and / or menstrual periods will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-3zb24z	Effect of cashew meal in the fight against child malnutrition	Recruitment completed	Intervention	2018-06-15	<NULL>	<NULL>	1901	Effect of cashew meal in the nutritional state of children with malnutrition	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal do Maranhão - UFMA	Universidade Federal do Maranhão - UFMA	https://ensaiosclinicos.gov.br/rg/RBR-3zb24z	<NULL>	Term birth. Age between 2 and 5 years. Both sexes. Malnutrition for at least 60 days. Preserved renal and hepatic function. Do not have allergy to products coming from cashew nuts. Mentally capable legal person	Severe malnutrition with z score less than -3. User of psychotropic, antimicrobial or antineoplastic. Carrier of syndromes. Chronic disease. Having started intervention for recovery of nutritional status.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-24tf9n	Direct current neuromodulation and its benefits in different populations	Data analysis completed	Intervention	2018-06-15	<NULL>	<NULL>	1902	Transcranial direct current stimulation and the  potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-24tf9n	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 18 to 60 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded. Patients with significant cognitive dysfunction were excluded. Patients were carefully evaluated by a physician	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-555xm5	Perioperative use of pregabaline in mastectomies	Data analysis completed	Intervention	2018-06-15	<NULL>	<NULL>	1903	Pregabaline as attenuator of Acute and Chronic Post-Operative Pain in mastectomies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-09	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-555xm5	<NULL>	Women&apos;s volunteers; scheduled for mastectomies; between 20 and 65 years; ASA II and III; without renal and hepatic comorbidities.	Women&apos;s Volunteers; scheduled for mastectomies; with hepatic and / or renal comorbidities; with BMI greater than 40; with low cognitive degree; not agreeing to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-56qkdc	Quality of care among people living with HIV/AIDS in Manaus and its influence on timely treatment initiation and adherence to antiretroviral therapy	Data analysis completed	Observational	2018-06-15	<NULL>	<NULL>	1904	Research on the quality of care among people living with HIV/AIDS in Manaus and its influence on timely treatment initiation and adherence to antiretroviral therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-19	Fundação de Medicina Tropical do Amazonas - FMT/IMT/AM	Manaus, LLC	https://ensaiosclinicos.gov.br/rg/RBR-56qkdc	<NULL>	The study participants were: People living with HIV/AIDS (PLHA) 18 years old or older; PLHA who received healthcare services at FMT or the four SAEs; and PLHA who had had at least one visit at any of these health centers.	The study did not interview patients who were visiting the health center for the first time at the time of the interview. The reason for excluding these new users is that patient satisfaction questions corresponded to the last consultation, which would be irrelevant to patients who were visiting the health center for the first time. The study also excluded patients younger than 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-3v2wgx	Quality of Life of pregnant women with Zika Virus	Recruiting	Observational	2018-06-16	<NULL>	<NULL>	1905	Quality of Life of pregnant women diagnosed with Zika Virus	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-05	Universidade Federal de Goiás - UFG	Universidade Federal de Goiás - UFG	https://ensaiosclinicos.gov.br/rg/RBR-3v2wgx	<NULL>	"Participants in this study will include  pregnant women notified with Zika Viruses (confirmed and
discarded) regardless of gestational age and age; residing in Goiânia and in the Metropolitan Region, who are prenatal in public health
primary care in Goiânia and in the Maternal and Child Hospital, and that they agree to participate in the
search."	"Pregnant women notified with Zika under the age of eighteen years will be excluded when there is no person responsible for signing the TCLE; pregnant women who present a deficit
cognitive or neurological, making it impossible to fill data; pregnant women who are prenatal in private health units and who do not
agree to participate in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-5cxc2j	Effects of Time of Application of Massage on Recovery of Pain and Muscular Strength after Unusual Exercise in Buttock and Thigh Muscles	Recruitment completed	Intervention	2018-06-16	<NULL>	<NULL>	1906	Effects of Time of Application of Massage on Recovery of Muscle Damage in the Extension Muscles of the Hip and Knee	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-30	Universidade de Brasilia -Faculdade de Educação Fisica	Universidade de Brasilia -Faculdade de Educação Fisica	https://ensaiosclinicos.gov.br/rg/RBR-5cxc2j	<NULL>	Healthy young people; male; age between 18 and 30 years; six months of experience with resistance training; that answer &quot;no&quot; to all questions in the Physical Activity Readiness Questionnaire	with osteomioarticular involvement of lower limbs; diagnoses of cardiovascular pathologies; respiratory function; angina; users of medications that may affect muscle function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-23snwx	Efficacy, safety and action of Microneedling and oral Tranexamic Acid in the treatment of facial Stains.	Recruiting	Intervention	2018-06-16	<NULL>	<NULL>	1907	Clinical trial about the efficacy, safety and mechanisms of action of Microneedling and oral Tranexamic Acid in the treatment of facial Melasma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Escola Paulista de Medicina (EPM/UNIFESP)	Escola Paulista de Medicina (EPM/UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-23snwx	<NULL>	women with mild to severe facial melasma with moderately to severe mMASI clinically proven by a dermatologist titled during the medical visit and who have been untreated for melasma for at least 30 days, except for the use of sunscreen	other concomitant facial dermatoses, photosensitivity dermatoses, collagenoses, blood dyscrasias or under the use of anticoagulant medication, immunosuppressed; pregnant and lactating women;phenotypic extremes red and black, because melasma is rarely mentioned in these groups. Obese, users of oral contraceptives, sedentary or with a personal or family history of previous thrombotic event have a higher risk of thromboembolism, so will be deallocated from the block with oral tranexamic acid	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-6c36pg	Performance between real and virtual environments in people with Autism Spectrum Disorders	Recruiting	Intervention	2018-06-18	<NULL>	<NULL>	1908	Analysis of motor performance between real and virtual environments in people with Autism Spectrum Disorders: crossover longitudinal study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c36pg	<NULL>	The signing of a free and informed consent by the parents or guardians of the minors; Term of assent by the minor; Children and adolescents with mild to moderate ASD; Which courses between 1st and 5th grade of elementary school.	People with severe ASD; Comorbidities such as Attention Deficit Hyperactivity Disorder and Down Syndrome; Use of medications that may interfere with the studied variables; Withdrawal during the protocol; Functional deficiencies that prevent the accomplishment of the tasks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-57qbjv	Clinical trial of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in patients with sickle cell disease	Not yet recruiting	Intervention	2018-06-18	<NULL>	<NULL>	1909	Phase II, randomized clinical trial on the anti-inflammatory effect of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in pediatric patients and young adults with sickle cell disease and vaso-occlusive symptoms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-08-01	Centro Infantil Boldrini	Centro Infantil Boldrini	https://ensaiosclinicos.gov.br/rg/RBR-57qbjv	<NULL>	Sickle Cell Disease patients; aged 08-30 years; patients who have vaso-occlusive pain episodes despite the regular use of hydroxyurea in the clinically-adjusted dose for a period equal or superior to 24 weeks	Absence of a signed Subject Information and Consent Form/Parents’ or legal guardian’s Informed Permission; renal or hepatic insufficiency; infection at enrollment time; pregnancy or breastfeeding; regular and/or frequent blood transfusions; refusal of contraceptive measures by females in reproductive age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-8dmfjf	Effectiveness of Acupuncture on Pain in the emergency room	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	1910	Evaluation of effects of Acupuncture in Pain in the emergency room	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-02	Instituto de Assistencia Medica do Servidor Publico Estadual	Instituto de Assistencia Medica do Servidor Publico Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8dmfjf	<NULL>	older than 18 year-old; neck pain; back pain; low back pain; hip pain; shoulder pain; elbow pain; wrist pain; knee pain; ankle pain; pain in the hands or feet; carpal tunnel syndrome or fibromyalgia	severe psychiatric disorders; chest pain; suspected fractures; requiring emergency care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-892vvp	Electrical current during gait training in people after Stroke	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	1911	Functional Electrical Stimulation during gait training in people post-Stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Associação Prudentina de Educação e Cultura Apec	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-892vvp	<NULL>	Sequel of Stroke with motor conditions of training; consent of the individuals with the due signature of the consent term.	Peripheral nerve damage in lower limbs; osteo-articular deformities; cognitive and visual deficits that interfered in the understanding and execution of the proposed training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2z2cjs	Evaluation of the effectiveness and sensitivity after tooth bleaching	Data analysis completed	Intervention	2018-06-19	<NULL>	<NULL>	1912	Effectiveness and sensitivity after bleaching gels carbamide peroxide based	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-03	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2z2cjs	<NULL>	Patients with all superior anterior teeth and with restorations in a maximum of 1/6 of the vestibular surface of each element; Be over 18 years of age; Good general and oral health conditions; Sign the free and informed consent form; Possibility of attending all sessions for research control; Had no professional prophylaxis during the study period	History of any medical disease that may interfere with the study or require special considerations such as diabetes and / or presence of pathology in the oral cavity (excluding caries); Be a smoker and / or have used tobacco in the last 30 days; Have used home and / or office bleaching agents in the last year; Gingival index score greater than 1.0; Pregnant or lactating women; Teeth stained by Tetracycline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-6gbzw6	Fish oil supplementation during pregnancy to prevent postpartum depression and possible effect on breastfeeding, growth and development of the child	Not yet recruiting	Intervention	2018-06-19	<NULL>	<NULL>	1913	Omega-3 supplementation during pregnancy to prevent postpartum depressive symptoms and possible effect on breastfeeding, child growth and development	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6gbzw6	<NULL>	Adult pregnant women; without multiple gestation; without diagnosis of high risk gestation; without previous supplementation with fish oil; without fish oil intolerance; without current or pre pregnant psychological treatment; without the use of psychiatric medications	Participants with postpartum depression score greater than or equal to 10 and need for medical treatment and / or medical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-989h4f	Clinical evaluation of restorations of posterior teeth using different types of composite resins	Data analysis completed	Intervention	2018-06-19	<NULL>	<NULL>	1914	Evaluation of admira fusion vs admira fusion xtra resins in posterior teeth restorations: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-989h4f	<NULL>	Presence of cavities, fractures or cosmetic demands; first or second molars and permanent premolars needing restorations; should be performed at least two Class II restorations in each patient (the number of restorations of each material should be equal in each patient); presence of the antagonist and the adjacent tooth making contact; pulp vitalized and absence of painful symptoms; teeth that have never been subjected to direct pulp capping; no history of hypersensitivity in the teeth to be restored; size of the isthmus with no more than 2/3 of the intercuspal distance; permanent dentition.	Presence of deleterious habits and bruxism;  bad oral health and presence of periodontal disease; patients who are suffering from severe systemic diseases or allergies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-9zgxzd	Effect of different types of physical exercise in SUS patients with depression	Recruiting	Intervention	2018-06-19	<NULL>	<NULL>	1915	Effect of different low-cost physical exercise programs on the mood indicator, cognitive function, physical activity level, cardiovascular risk and cost with treatment in patients with SUS depressive disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-20	Universidade de São Paulo - Escola de educação Física e esporte	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9zgxzd	<NULL>	Have a diagnosis of major depressive episode (single or recurrent episode by the Mini International Neuropsychiatric Interview (MINI), evaluated by a psychiatrist-trained evaluator; use of pharmacological treatment for mental health (use of anxiolytic drugs or antidepressants); did not participate in a systematic exercise program in the last 6 months and be able to perform systematic physical exercise (medical authorization); be over 40 years of age; do not have chronic degenerative diseases, dementias (score &lt;23 in the Mini Mental State Examination), joint or muscle injuries that prevent him from carrying out systematized physical exercises.	Not being willing to participate in evaluations; Not having availability of participation of interventions that will occur on weekdays; make use of walking sticks, crutches or other support that hinder the practice of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2s5bhm	Clinical evaluation of two restorative approach for non-carious cervical lesions	Data analysis completed	Intervention	2018-06-20	<NULL>	<NULL>	1916	Clinical evaluation of Class V restorations using a semi direct technique - a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Instituto de Ciência e Tecnologia de São José dos Campos (ICT/SJC) - Universidade Estadual Paulista (UNESP)	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-2s5bhm	<NULL>	"• Be at least 18 years of age;
• Provide good general health;
• Do not introduce active decay or periodontal disease;
• Class V lesions, non-carious in canines premolars or with a minimum depth of 1 mm."	Medical condition that might interfere with the safety of the volunteer during the study period, or allergic reaction to substances and/or products used in the study; use of removable prosthesis with clamp resting on the study tooth; presence of caries or periodontal disease; patients under orthodontic treatment; tooth with endodontic treatment; smoking patients, patients with parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-9vddmr	Mucosadhesive formulation for Oral Mucositis relief (PHASE II and III)	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1917	Randomized double blind clinical trial of Phytomedicine for prophylactic and curative purposes of Oral Mucositis (PHASE II and III)	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-05-08	Faculdade de Odontologia da Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9vddmr	<NULL>	Cancer patients with head and neck cancer; Age greater than 18 years; Programmed to receive radiation therapy; Presence of intact buccal mucosa.	Patients with salivary gland infections or tumors; Patients with Sjögren&apos;s syndrome; Buccal mucosa presenting wounds; Indication for chemotherapy alone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-2ss28r	Associations Among Bed Bath, Sleep and Body Temperature in Intensive Care Patients	Not yet recruiting	Observational	2018-06-20	<NULL>	<NULL>	1918	Associations among Bed Bath, sleep characteristics and body temperature in the critically ill: A cross-sectional study with the Bispectral Index®	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Hospital de Clínicas da Universidade Federal do Paraná	Instituto de Tecnologia para o Desenvolvimento - Lactec	https://ensaiosclinicos.gov.br/rg/RBR-2ss28r	<NULL>	Adult and elderly critically ill individuals; admitted at the intensive care unit 2 of the Hospital de Clínicas da Universidade Federal do Paraná; with mild and moderate gravity diseases; with perspective of spending the next night at that unit; and that are able to understand and accept the terms of the Informed Consent.	Individuals with severe organ disfunction; wich compromise the comprehension and acceptance of the terms of the Informed Consent; individual who don&apos;t accept these terms; those identified as delirious; those who decide to leave the study after the inclusion. Individuals may decline participation at any time independently of justification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8zm6cv	Evaluation of Dental Sensitivity and Color Changes after Dental Bleaching in adults and adolescents	Not yet recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1919	Evaluation of Dental Sensitivity and Efficacy of Dental Whitening in adolescent and adult patients: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Faculdade de Odontologia de Pernambuco - Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8zm6cv	<NULL>	To be 12 to 20 or 40 to 50 years of age, have all permanent anterior teeth; have coloration above A2 on the VITA Classical Shade guide	To present allergy to the bleaching agent; to start orthodontic treatments, to perform restorative procedures on the buccal surface of elements 11, 21, 13, 23, 31, 41 and/or 33; not to complete the bleaching treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-2xn3g6	Impact of active video game on adolescent health	Not yet recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1920	Impact of exergame on cardiorespiratory function, macro and microcirculation of overweight adolescents: a randomized intervention study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-05	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2xn3g6	<NULL>	To be enrolled and attending the classes from the 5th to the 9th year of the public school network of the urban area of ??Campina Grande-PB selected for the study; being in the age group of 10 to 18 years; have nutritional status characterized as being overweight or obese.	"Present some motor (although temporary) or mental limitation that impedes the participation in the activities of the intervention and / or the accomplishment of the exams, as the pulmonary function tests; have any severe metabolic changes that require the use of medications or specific treatment that alter the metabolism of the lipid profile; have asthma with a recent crisis (two months prior to data collection) and / or report of exercise-induced bronchospasm; not being, at the time of the research, overweight treatment, and active video game users; 
for women, being pregnant or breastfeeding."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-26cq7n	Effects of antioxidant supplementation Coenzyme Q10 in women with Metabolic Syndrome and liver fat	Recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1921	Effects of Coenzyme Q10 suplementation in women with Metabolic Syndrome and hepatic steatosis: double-blind controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26cq7n	<NULL>	women; age between 20 and 55 years; sedentary; not menopausal; Body mass index less than 40 kg / m2; carrier of Metabolic Syndrome; with hepatic steatosis.	current gestation / lactation; smoking; alcoholism; inflammatory rheumatologic, intestinal and hepatic diseases; confirmed cancer; polycystic ovary syndrome; confirmed diabetes mellitus (type 1 or 2); refractory arterial hypertension; thyroid disease; use of Ginkgo biloba and statins; Supplementation with vitamin E or CoQ10 in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-335kdt	Effects of Laser application on the Single Hop Test of the knee	Recruitment completed	Intervention	2018-06-21	<NULL>	<NULL>	1922	Effect of Low Level Laser (LLL) in Functional Assessment (Single-Hop) of the knee	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-10	Universidade Anhanguera - Uniderp	Universidade Anhanguera - Uniderp	https://ensaiosclinicos.gov.br/rg/RBR-335kdt	<NULL>	women; professional handball player; practice of handball for at least four years and conducted training for at least five days a week; age between 15 and 30 years.	Any previous musculoskeletal injury to the knee, hip or ankle regions; participation less than 80% of the regular physical training of the handball team; use of any type of nutritional or pharmacological supplement and that contraindication to the use of the low power laser	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9w378x	The Effect of Early Physical Therapy on Heart Response in Subjects After Stent Placement by Heart Infarction	Recruitment completed	Intervention	2018-06-25	<NULL>	<NULL>	1923	Influence of Early Mobilization in the Variability of Heart Rate in subjects after Angioplasty by Acute Myocardial Infarction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal do Triângulo Mineiro - UFTM	Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-9w378x	<NULL>	"Patients hospitalized at the Coronary Intensive Care Unit of the HC - UFTM;Patients of both sexes, with age greater than or equal to 18 years;
Medical diagnosis of uncomplicated AMI (Killip I and II) with electrocardiogram (ECG) with or without ST segment elevation (successfully submitted to PTCA with residual stenosis of less than 50%).Have a sufficient level of understanding to understand the exercises to be performed (assessed by the Glasgow Coma Scale: score 3 to 15);Agree to participate in the research - signing the Term of Consent"	Patients with a history of previous MI, complicated MI (Killip III and IV); Signs and / or symptoms consistent with angina after AMI or reinfarction; Persistent anomalous pressure behavior (refractory hypertension with levels above 180 / 110mmHg); Atrial fibrillation; Malignant ventricular arrhythmias; Complex ventricular extrasystoles; Supraventricular or sinus tachycardia (greater than 120 beats per minute); Atrioventricular block of 2nd or 3rd degree; Implantation of pacemaker; Signs of low output or ventricular failure; Hypotension; Febrile state; Respiratory failure; Sequence of stroke; Lower limb amputation; Severe aortic stenosis; Left coronary trunk lesion&gt; 50%; Previous surgery of myocardial revascularization; Impossibility of progression in the protocol and hospital admission after 48 hours of the initiation of AMI	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8zmmgm	Effect of Baru Almond Intake by Adults with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1924	Metabolic Syndrome: prevalence and effect of Physical Exercise and Nutritional Supplementation in adults and the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8zmmgm	<NULL>	Adult subjects; aged between 20 and 59 years; with self-reported diagnosis of type 2 diabetes mellitus	Individuals using insulin therapy; with a history of cardiovascular disease (infarct in the last six months, unstable angina, cardiac arrhythmia and stroke); cancer; diagnosed chronic lung disease; musculoskeletal problems ; neurological deficit; with frequent consumption of some type of nut (more than 2x / week); participants in a restriction and food education program; participants in a guided exercise program; individuals with nut  and / or seeds allergy, pregnant; nursing women; women in hormonal replacement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-758cbn	A Phase I/II open-label study at a single research center to evaluate the safety, tolerability, and effects of RGX-111 gene therapy given directly into the central nervous system in subjects with severe mucopolysaccharidosis type I	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1925	A phase I/II single center, open-label study to evaluate the safety, tolerability,  pharmacodynamics and preliminary efficacy of intracisternal RGX-111 gene therapy in subjects with severe mucopolysaccharidosis type I	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2018-11-01	Hospitais de Clínicas de Porto Alegre	REGENXBIO Inc.	https://ensaiosclinicos.gov.br/rg/RBR-758cbn	<NULL>	A male or female less than 3  years of age; The subject’s legal guardian(s) is(are) willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures; Has a documented diagnosis of severe Mucopolysaccharidosis Type I (MPS I) -Hurler confirmed by homozygosity or compound heterozygosity for mutations exclusively associated with the severe phenotype; Has an intelligent quotient (IQ) score of  greater than or equal to  55; Has sufficient auditory and visual capacity, with or without aids, to complete the required protocol testing and willing to be compliant with wearing the aid, if applicable, on testing days	"Has a contraindication for an intracisternal injection (IC); Has any neurocognitive deficit not attributable to Mucopolysaccharidosis Type I (MPS I) or has a diagnosis of a neuropsychiatric condition that may, in the opinion of the PI, confound interpretation of study results; Has any contraindication to lumbar puncture; Has undergone hematopoetic stem cell transplantation (HSCT); Has had prior treatment with an Adeno-associated virus (AAV)-based gene therapy product; Has received intrathecal (IT) laronidase at any time and experienced a significant Adverse event (AE) considered related to IT administration that, in the opinion of the PI, would put the subject at undue risk; Has a platelet count less than 100,000 per
microliter; Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 × upper limit of normal (ULN) or total bilirubin greater than 1.5 × ULN at screening, unless the subject has a previously known history of Gilbert’s syndrome; Has a history of human immunodeficiency virus (HIV) or hepatitis B or hepatitis C virus infection, or positive screening tests for hepatitis B surface antigen or hepatitis B core antibody, or hepatitis C or HIV antibodies"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-3dmq83	Effects of probiotic administration in the elderly	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1926	Efficacy of administration of Probiotics in institutionalized elderly	<NULL>	1, single-arm-study, triple-blind	1	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3dmq83	<NULL>	- To be 60 years or more; being institutionalized; obtain values between 10 and 24 in the Mini Mental State Examination (MMSE), to exclude individuals with very mild dementias and very severe dementias; be able to walk	-Be less than 60 years; not being institutionalized; obtain value less than 10 and greater than 24 in the Mini Mental State Examination (MMSE); not being able to walk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-3ft2rq	Effects of robotic therapy on the gait of post-stroke individuals	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1927	Effects of robotic therapy on the gait kinematics of chronic hemiparetic individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-30	Universidade de São Paulo	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3ft2rq	<NULL>	The subjects who present the last episode of stroke, single, unilateral and ischemic for more than 6 months, without documented changes in motor or sensory impairment, will be included in the study; muscle tone or reflex activity in the 3 months prior to the subject&apos;s participation in the study; the level of spasticity equal to or less than 2 in the Modified Ashworth Scale for lower limbs, allowing individuals to perform the test, 3 to 5 according to the Functional Ambulation Category. The ankle joint should be kept in a neutral position and without deformities. In addition, they must present a minimum score in the Mental State Mini Exam according to the volunteer&apos;s schooling. The Beck Depression Scale inventory will be used to identify individuals with depression. Individuals with values greater than 63 will be excluded. The age range will be between 40 and 70 years.	Subjects with severe cardiovascular diseases, heart failure, arrhythmias or angina pectoris, will be excluded from the study; rheumatic diseases; body mass index greater than 28 kg/m² changing the reliability of the EMG data; other orthopedic or neurological diseases that compromise the collection of data through the isokinetic test and cognitive or communication deficiencies that make it impossible to perform the procedures; painful contractures or deformities in the paretic ankle; shortenings that make it impossible to perform tests or promote pain; show the range of motion less than 10o for dorsiflexion and 20o for plantar flexion according to goniometry; cerebellar ataxia; sensory deficit defined by the loss of proprioception of the first phalangeal metatarsus; hemi- sensorial neglect on neurological examination; various neurological disorders; participation in rehabilitation programs; the presence of pain during the procedures will be considered exclusion criterion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-5sgsxb	Effects of training the muscles of inspiration associated with the foundation workout of the wheelchair basketball tray on the strength of the breathing muscles and physical performance of high performance athletes	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1928	Effects of inspiratory muscle training associated with the training of the wheelchair basketball tray foundation on the aerobic physical performance, cardiopulmonary and metabolic variables of high-performance athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5sgsxb	<NULL>	practice wheelchair basketball at a competitive level for more than five months; train at least three times a week; compete in official championships of the sport	smoking; presence of cardiovascular respiratory and motor alterations that made impossible the execution of evaluation or intervention protocols; inability to understand the techniques for implementing the evaluation and intervention protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-4w9ht3	Evaluation of pain after dental bleaching done at home, with and without the presence of reservoirs in the trays	Recruitment completed	Intervention	2018-06-25	<NULL>	<NULL>	1929	Evaluation of the presence and absence of reservoirs in a home bleaching tray: randomized, multicenter and blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4w9ht3	<NULL>	Applicants must possess all canine teeth to upper and lower canine; without caries manifestations; restorations; exposed dentin and spontaneous tooth sensitivity. Able to sign a free and informed consent form. Be between 18 and 30 years old. Commit to attend for periodic examinations. Have good oral and general health. Canines with color A2 or darker compared to color scale (Vita Lumin, Vita Zahnfabrik, Bad Säckingen, Germany)	Patients who have previously performed the bleaching procedure. Pregnant or nursing. Patients with tetracycline staining (grade I, II, III or IV); fluorosis or endodontic treatment in the anterior teeth. Patients with bruxism and severe periodontitis. Continuous use of some medicine with anti-inflammatory or antioxidant action. Patients who present and / or report spontaneous dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8sxw2r	Comparison of the analgesic effect between acupuncture and dipyrone in acute tooth pain	Recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1930	Comparative analgesia between acupuncture and dipyrone in acute tooth pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-8sxw2r	<NULL>	Adult subjects; ages 18-45; of both sexes who are not using any type of pain medication in the last 12 hours with complaint of acute tooth pain of pulp origin equal to or greater than 4 in VAS; non-allergic to dipyrone.	"Patient under 18 years of age; pregnant women; acute tooth pain of less than 4 VAS intensity; toothache of non-pulp origin;
volunteers who are using some type of pain medication; allergic to dipyrone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8s4gfg	Computer aid to carry out school activities in individuals with Down Syndrome	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1931	Assistive Technology Device for conducting school activities in individuals with Down Syndrome: enhancement of the Augmentative and Alternative Communication	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8s4gfg	<NULL>	present the Informed Consent Form (TCLE); to sign the Free and Informed Consent Term (TALE); to understand the proposed task; able to perform the necessary movement; do not present symptoms of pain or discomfort during the execution of the tasks.	do not understand the task; do not want to perform the movement necessary to perform; have symptoms of pain or discomfort during the execution; limitations of movements in the upper limbs; visual limitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9kf3nq	Therapeutic value of counseling in the treatment of headache over medication use	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1932	Therapeutic value of counseling in the treatment of headache over medication use	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-23	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9kf3nq	<NULL>	Diagnostic of medication overuse headache at first appointment in Oswaldo Cruz University Hospital&apos;s headache clinics	Cognitive deficit witch restricts patient capacity to answer the questionnaires; patients taking analgesics for other type of pain besides headache; secundary headache diagnosis; pregnancy or breast-feeding; opiods overuse; previous tentative of medication overuse&apos;s withdraw; under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8bq75m	Research and stimulation on the use of eight practices that promote health in the city of Uberaba MG	Not yet recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1933	Inquiry use of eight practices that promote health in the municipality of Uberaba MG	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal Do Triângulo Mineiro	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8bq75m	<NULL>	Both sexes; age above 18 years; literate; with a minimum score of 23 in the Mental State Mini Exam; agree to participate in the meetings; sign consent form	Give up the study; not answer the questionnaires completely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9bhbrp	Changes in oxygenation of skin and muscles after the use of Functional Bandage in women with Varicose Veins	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1934	Kinesio Taping use in tissue oxygenation in women with Chronic Venous Insufficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9bhbrp	<NULL>	Must be female, be between 30 and 79 years old and present the diagnosis of chronic venous insufficiency (confirmed by Duplex Scan) or classified in stages C1, C2 or C3 of CEAP. To be included in the study the participants may not be on hormone replacement therapy and may not have symptoms of intermittent claudication, lymphedema, diagnosis of thrombosis for less than three months, heart failure, and no other type of conservative treatment for IVC, or have undergone sclerotherapy or surgery in the past three months. In addition, they can not present any contraindication to the use of KT such as open sores, trauma, edema arising from heart or kidney disease, cancer, KT allergy, and pregnancy. All participants must agree to participate in the research by signing the Informed Consent Term.	Participants who present knesio taping allergy or intolerance will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9p42nj	Proposal of a clinical guideline for attention to women with Urinary Incontinence in public health policy	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1935	"A proposal of the superiority of clinical evaluation on urodynamics in
diagnosis of urinary incontinence in women"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-01	Universidade Federal de São Paulo	Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM,	https://ensaiosclinicos.gov.br/rg/RBR-9p42nj	<NULL>	Patients with complaints of urinary incontinence. Patients who submitted to the Urodynamic Study, Patients who signed the Free and Informed Consent Form	Patient with urinary infection at the moment of the Urodynamic Study. Patients with neurogenic bladder. Patients who refused to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-26wwhz	Behavior in virtual task of people with Down syndrome	Recruiting	Intervention	2018-06-27	<NULL>	<NULL>	1936	Analysis of virtual task performance in people with Down syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26wwhz	<NULL>	Medical diagnosis of Down Syndrome; cognitive conditions to understand the orientations in relation to the task proposed in each game; and to be able to perform the necessary movement and not present symptoms of pain or discomfort during the execution of the tasks; authorization of the responsible, with the signed free informed consent term and free and informed consent term.	People with cognitive impairments that make it impossible to collaborate and understand simple orders in the proposed activities; Functional deficiencies that impede the accomplishment of the tasks; Withdrawal during the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-6cwmqc	Effect of Functional Bandaging on Women&apos;s Flexibility	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1937	Acute effect of the application of Functional Elastic Bandage on the flexibility of active young women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade Estácio de Sergipe	Faculdade Estácio de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cwmqc	<NULL>	Physiotherapy students of the Faculdade Estácio de Sergipe; Women; age from 18 to 30 years; they did not practice regular physical exercises; they did not report low back pain at the time of the evaluation	Women who were in the menstrual period, puerperal, presence of scar in the application area and those who presented an allergy to functional elastic bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-7m7vc8	Telemonitoring to improve maternal confidence in breastfeeding	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1938	Telemonitoring for improving maternal self-efficacy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7m7vc8	<NULL>	"Women in the immediate puerperal period, considered the period between the first and tenth day after childbirth;
Puerperas with at least six hours postpartum, since before that moment it would be inopportune to perform data collection, judging that the first hours after childbirth are characterized by emotional stress for the mother, making it even more difficult due to the physiological changes that occur;
Single term full term puerperal women (gestational age ? 37 weeks, &lt;41 weeks), since the clinical conditions and the environment in which the preterm newborn is hospitalized are factors that may hinder breastfeeding, in addition to that in some situations it is necessary to initiate the use of milk formulas in the child&apos;s diet;
Bereaved children 12 years of age or over, considering the Statute of the Child and Adolescent, Law No. 8,069 / 90;
Puerperas with newborns hospitalized in joint housing;
Puerperas that are practicing the AM;
Puerperas who have at least one telephone contact."	"Puerperas who declared their intention not to breastfeed;
Puerperas with age &lt;12 years or&gt; or equal to 60 years;
Puerperas that presented clinical intercurrences at the time of data collection (heart disease, nephropathy, diabetes, hypertension, among others);
Women with obstetric complications in the puerperal period (anemia, transvaginal bleeding, post-rachidial headache, among others);
Puerperas that presented some type of contraindication to breastfeeding (Acquired Immunodeficiency Syndrome, chemical dependency, among others);
Puerperas with mental restrictions that precluded the understanding of the instrument;
Puerperas who performed breast reduction or who had breast augmentation because, although these procedures do not contraindicate breastfeeding, in general, women who undergo breast reduction may decide not to breastfeed;
Puerperas with children hospitalized in the intensive care unit, judging that the sector is home to newborns with critical clinical conditions that may make breastfeeding impossible;
Puerperas whose children were born with disabilities that prevented or hindered breastfeeding (cleft palate, atresia of the esophagus, among others);
Puerperas with hearing impaired."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-3x5c7g	Treatment of Stress Urinary Incontinence in menopause	Recruiting	Intervention	2018-06-27	<NULL>	<NULL>	1939	Clinical study randomized in the treatment of Stress Urinary Incontinence in women in post-menopause	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	SOBEU - Associação Barramansense de Ensino	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-3x5c7g	<NULL>	Age range between 40 and 90 years; minimum period of one year of amenorrhea before the evaluation; without cognitive and or communication problem; who agree to participate in the study according to the informed consent.	Patients less than 40 years and older than 90 years; continents; who have urinary incontinence other than effort; have neurological; visual; auditory; cognitive; oncological; prolapse; intact hymen; vaginal narrowing; vaginal or urinary infection; gynecological uterus; recent gynecological surgery; skin lesions or diseases; allergic processes to the functional elastic bandage or the condom used; musculoskeletal conditions that prevent the performance of the tests and or treatment; being in another physiotherapeutic treatment for the pelvic floor musculature and who refuse to sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2m67zd	Comparison the effect of HDx therapy and high flux hemodialysis on endothelium function in hemodialysis patients	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1940	A randomized, open-label, crossover, clinical trial to compare the effect of HDx therapy versus high flux hemodialysis on endothelium function in hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Oswaldo Ramos - Hrim	Fundação Oswaldo Ramos - Hrim	https://ensaiosclinicos.gov.br/rg/RBR-2m67zd	<NULL>	"Male and female aged 18 years old;in hemodialysis program for at least 6 months before the enrollment; with adequate vascular access; hemodialysis 4 hours 3 times/week;
with a result of KtV 1.2 in the 3 months prior to the study and signed the ICF."	Patients with Heart failure III or IV NY class; peripheral arterial disease, previous stroke within the last 3 months before the enrollment; active inflammation or infection disease within the last 3 months before the enrollment; pregnant or lactating female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8d8rj7	"90/5000
Different devices to interact with virtual environment in people with Multiple Sclerosis"	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1941	"Analysis of different interaction devices during a Timing Task
Coincident in virtual environment in people with Multiple Sclerosis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-19	Universidade  de São Paulo	Associação Brasileira de Esclerose Múltipla	https://ensaiosclinicos.gov.br/rg/RBR-8d8rj7	<NULL>	Multiple Sclerosis diagnosis of recurrent remitting type	Changes in motor functions and pain in the dominant upper limb; during or up to one month prior to data collect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-33vyhm	Comparative study of analgesia by the use of intravenous and subarachnoid clonidine in patients submitted to Videoolaparoscopic Cholecystectomy	Recruitment completed	Intervention	2018-06-29	<NULL>	<NULL>	1942	Comparative study of the use of intravenous and subarachnoid clonidine in patients submitted to Videoolaparoscopic Cholecystectomy	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-08-23	Fundação Universidade do Amazonas	Hospital Universitário Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-33vyhm	<NULL>	Voluntary patients; of both sexes; with full autonomy; ages ranging from 18 to 50 years; weight between 50 and 100 kg; with diagnosis of cholelithiasis; classification I or II of the physical state according to the scale of the American Society of Anesthesiologists.	Patients who refuse to sign the informed consent form (EHIC); withdrawals; pregnant or nursing mothers; indigenous peoples; minor or legally incapable; patients with special needs; patients on uninterrupted use of analgesics; with a history of hypersensitivity to any of the medications used in the procedure; patients diagnosed with depression; patients with liver disease, nephropathy or with blood coagulation disorders; conversion of videolaparoscopic surgery in conventional open surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-3dv7gc	Epidemiological research on the internet: research strategies and individual characteristics that influence the adherence and participation of young adults.	Recruitment completed	Intervention	2018-06-29	<NULL>	<NULL>	1943	Internet-based epidemiological research: strategies and individual characteristics associated to recruitment and participation of young adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	Centro de Pesquisas Epidemiológicas da Universidade Federal de Pelotas	Centro de Pesquisas Epidemiológicas da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-3dv7gc	<NULL>	Be a member from the 1993 Pelotas birth cohort; have participated in the 2015 face-to-face follow-up of the 1993 cohort, held in 2015; have responded to the questionnaires applied during the face-to-face follow-up in 2015, without assistance; have Internet access in 2015; have provided an e-mail address, a Whatsapp number and a Facebook profile name in 2015	Have an invalid CPF number; have not accepted the terms and conditions of the coortesnaweb platform	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-94c26n	Noninvasive brain stimulation to improve the gait of children with cerebral palsy	Not yet recruiting	Intervention	2018-06-29	<NULL>	<NULL>	1944	Transcranial electrostimulation to facilitate gait rehabilitation of children with spastic cerebral palsy: cross-over randomized clinical trial, placebo-controlled, double-blinded	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade de Sorocaba	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94c26n	<NULL>	The children will be screened for participation in the study according to the following criteria:diagnosis of spastic CP confirmed by clinical examination; to obtain magnetic resonance imaging of the brain performed no more than two years before the beginning of the intervention; demonstrating lesion in the pyramidal system; without compromising the extrapyramidal system and cerebellum; age between five and 15 years; children levels I, II and III of GMFCS; children who have a muscular form degree equal to or greater than three in the flexor and extensor muscles of the trunk, hips and knees;  degree of spasticity of less than three in the Modified Ashworth Scale; agreement of those responsible by signing the Term of Free and Informed Consent.	Children will be excluded if are diagnosed with epilepsy or have had seizures at least 12 months before the beginning of the study, present neurological, neuromuscular or syndromic diseases associated with brain injury; have undergone orthopedic or neurological surgeries in the 12 months prior to the intervention; have undergone neurolithic blockade in the 12 months prior to intervention; present orthopedic deformities with surgical indication; have brain implants or have performed some neurosurgical procedure; have metallic implants in the regions of head, neck, thorax and / or upper limbs, have hearing aids; children with a degree of collaboration incompatible with the adequate performance in the activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-9mys6q	Effect of the use of Toothpaste with Desensitizers in reducing Dental Sensitivity and Quality of Life after in-office Dental Bleaching	Data analysis completed	Intervention	2018-06-29	<NULL>	<NULL>	1945	Effect of the use of Dentifrices with Desensitizers in the ental Sensitivity reduction and Quality of Life after in-office Dental Bleaching: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9mys6q	<NULL>	with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; they should  be dissatisfied with the color of their teeth; they should have upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale in order of luminosity.	stimulated or provoked dentin sensitivity; enamel cracks; dentinal exposures; severe intrinsic stains on the teeth (such as tetracycline or fluorosis); periodontal disease without treatment;  using any anti-inflammatory, analgesic and antioxidant action drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8bfjgk	Computer Games for Autistic Communication	Recruiting	Intervention	2018-06-29	<NULL>	<NULL>	1946	Virtual Reality and Augmentative and Alternative Communication in Autism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8bfjgk	<NULL>	Initially, all the individuals with a diagnosis of ASD; of both sexes; will be included in the study; who will follow up at APAE in Vitória-ES and Vila Velha-ES (for GE) and FMABC Outpatient Neurology; individuals with typical development; paired by age; and gender to the GE; members of the public school Dr. Geraldo José Rodrigues Alckmin in Potim, SP (for the GC).	Individuals who can not understand the orientations in relation to the proposed task; present some limitation of movement of the upper limbs; and / or limitation in visual acuity that prevents them from performing the game; and / or are unable or unwilling to complete the proposed task will be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-5n4686	Electronic Record for Continuity of Patient Care: A use case for Doctor&apos;s handovers in hospitals.	Recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1947	Electronic Record for Continuity of Patient Care: A use case for Doctor&apos;s handovers in hospitals.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Hospital das Clínicas  Universidade Federal de Minas Gerais - HC-UFMG	https://ensaiosclinicos.gov.br/rg/RBR-5n4686	<NULL>	Eighteen documents of physician handover session before intervention and 18 after the intervention randomly selected for monitoring.	Clinical documents of handover session which physicians do not agree with the voluntary participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2gwjgj	Use of Virtual Immersion Therapy to improve the Posture, Balance and Walking of children with  Hearing Loss	Not yet recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1948	Effectiveness of a training program using Virtual Immersion Therapy to improve Postural Control stability, Body Balance and Gait of children with Sensorineural Hearing Loss: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Pernambuco - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-2gwjgj	<NULL>	The children must be enrolled or in attendance in the collaborating institutions of this study; to be in the age group between 7-11 years of age; to present, through a medical report, diagnosis of sensorineural hearing loss; to have degrees of hearing loss (severe to profound) (values higher than 70 dB); dominate the Brazilian sign language, this last criterion will be used to ensure that all the commands referring to the demands of the methodology will be understood by all children, we also point out that, all children have access to learning the Brazilian language of signs in your institution of education and the child must undergo exams of auditory and vestibular function	Present any associated physical, neurological or cognitive deficits (except vestibular dysfunction); children with hearing loss using cochlear implants; Discrepancy in lower limbs greater than 2 centimeters; Children who are engaged in recreational or sports activities on a regular basis, such as ballet, soccer, swimming, or other sports training at school	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8y49vf	Leukocyte- and Platelet-Rich Fibrin for preventing Osteoradionecrosis following Tooth Extraction	Not yet recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1949	Leukocyte- and Platelet-Rich Fibrin for Preventing Osteoradionecrosis following Tooth Extraction: an exploratory study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	Universidade Ibirapuera	Hospital Heliópolis	https://ensaiosclinicos.gov.br/rg/RBR-8y49vf	<NULL>	Previous 3D conformational radiotherapy for head and neck cancer; total radiotherapy dose from 50Gy to 70Gy; at least 18 years of age; able to undergo dental surgery.	Disease recurrence (cancer); drugs that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; diseases that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; tobacco use; radiotherapy for head and neck cancer more than once.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2sv9gw	Determination of the best dose for the electrostimulation of the paravertebral muscles in the force in individuals without chronic low back pain	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1950	Determination of the dose-response for the stimulation of the multiphids in the core strength in individuals without chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-2sv9gw	<NULL>	University students of both sexes; aged between 18 and 40 years; without musculoskeletal disease or lesion in the spine or lower limbs	Uncontrolled systemic diseases, such as diabetes or hypertension; as well as volunteers who report systematic physical activity at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4ccv6f	Repercussions of electrostimulation in women with breast cancer during chemotherapy	Not yet recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1951	Repercussions of Transcutaneous Nervous Electric Stimulation applied to PC6 acupuncture point in women with breast cancer during chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	universidade federal de santa maria	universidade federal de santa maria	https://ensaiosclinicos.gov.br/rg/RBR-4ccv6f	<NULL>	Women with indications of chemotherapy neoadjuvant or adjuvant, of high and moderate emetogenic potential; age between 35 and 75 years	Central nervous system metastasis;second chemotherapy treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4crf4d	The effect of caffeine on people&apos;s perception of tinnitus	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1952	Effect of caffeine intake in tinnitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade de Brasilia - UnB	Instituto Brasiliense de Otorrinolaringologia - IBORL	https://ensaiosclinicos.gov.br/rg/RBR-4crf4d	<NULL>	Volunteers who are over 18 years of age and who seek medical consultation with tinnitus	Objective tinnitus, or acute tinnitus, or who have psychiatric and / or cognitive disorders, or alteration of the middle and / or external ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-95c4rd	Rehabilitation of patients after meniscus surgery	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1953	Influence of a rehabilitation protocol and associated or not with the low intensity laser without treatment of patients without post-surgical meniscal lesion	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-17	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95c4rd	<NULL>	Individuals in the postoperative period of partial meniscectomy of the lateral or medial meniscus; aged between 18 and 60 years, who are referred by the orthopedic sector of the Hospital São Judas Tadeu of the city of Meleiro	Presence of rheumatic, systemic, cognitive; polytraumatized patients that make the execution of the project impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-6p9ncq	Physical exercise can reduce the accumulation of fat, improve the immunity and quality of blood in people living with HIV/aids.	Data analysis completed	Intervention	2018-07-04	<NULL>	<NULL>	1954	Effects of a program of physical exercise in body composition, immune system and blood changes of people living with HIV/AIDS: a clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-6p9ncq	<NULL>	Healthy volunteers; both genders; age between 18 and 50 years; carriers of the HIV virus; regular users of antiretroviral therapy; sedentary.	Volunteer smokers; alcohol abuse; physical limitation for exercise; chronic diseases; cardiorespiratory diseases; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; disuse of therapy; incorrect training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-3n8n8b	The effect of Group Physiotherapy on quality of life, improvement of pain and shoulder movements and emotional conditions of patients with shoulder pain	Not yet recruiting	Intervention	2018-07-04	<NULL>	<NULL>	1955	The Effect of Group Physiotherapeutic Intervention on the quality of life, functionality and psychic condition of patients with Shoulder Impact Syndrome	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual Paulista	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3n8n8b	<NULL>	Diagnostic confirmation by clinical examination or image examination; Neer positive test; Hawkins test positive; pain during resistive isometric abduction; pain during passive or isometric lateral rotation resisted; pain during active shoulder lift; pain in the palpation of the rotator cuff tendons and pain in the region of the C5 and C6 dermatome.	Bilateral pain; age less than 40 years; pregnancy; systemic pathologies; physical therapy less than 3 months before the evaluation; signs of total rupture or acute inflammation of the rotator cuff; cervical spine-related symptoms; instability of the glenohumeral joint and history of fracture or surgery in the affected limb.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-7zcgdd	Effects of a water-based Exercise Program in elderly women with Knee Osteoarthritis	Data analysis completed	Intervention	2018-07-04	<NULL>	<NULL>	1956	Comparison of the effects of an Exercise Program performed in water or land in elderly with Hip or Knee Osteoarthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Departamento de Educação Física da Universidade Federal do Paraná	Centro Universitário Unibrasil	https://ensaiosclinicos.gov.br/rg/RBR-7zcgdd	<NULL>	Women; age from 60 years; diagnosed with knee osteoarthritis by a physician; able to walk with no help of assistive device; able to practice exercise.	Elderly women with diagnosed osteoarthritis or prosthesis in other lower limb joint; with medical restrictions to physical activity; participating on exercise program in last six months; with ortopaedic surgery in last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-556d22	Efficacy of Pushing Down Free Compared to Pushing Down With Command in Maternal and Neonatal Outcomes: A Randomized Clinical Trial.	Recruiting	Intervention	2018-07-04	<NULL>	<NULL>	1957	Efficacy of Spontaneous Pushing Compared to Directed Pushing in Maternal and Neonatal Outcomes: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-556d22	<NULL>	Women in the second period of labor; Low- and high-risk gestation; Gestational age between 37 and 42 weeks, between 19 and 45 years.	Twin pregnancy; Gestation with a dead fetus; Induced birth; Use of Oxytocin; Use of psychoactive drugs; Use of pharmacological analgesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4m6zdh	Behavior of multiple sclerosis patients&apos; view in computer use	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1958	Evaluation of the visual performance of people with multiple sclerosis in the use of tasks in virtual environment	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4m6zdh	<NULL>	All patients with multiple sclerosis; Both sexes; aged between 21 and 80 years; that presents some type of visual deficit except total or partial blindness	Deformity or muscle weakness in the upper limbs that prevent the manipulation of the equipment; outbreak in the last month; surgery or chemical neuromuscular block in the upper limbs in the last two months before participating in the study; presence of disorders in cognitive function and vision that potentially undermine the understanding of the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-6xqrtr	Use of the low-level Laser therapy in the treatment of Inflammation in the lateral region of the knee in women with Femoropatelar Pain	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1959	Use of the low-level Laser therapy in the treatment of inflammation in the Iliotibial Treatment in women with Femoropatelar Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-6xqrtr	<NULL>	Anterior or retropatellar knee pain when performing at least two of the following activities: sitting for prolonged time, squats, kneeling, running, climbing and descending stairs, and in jumps and landings, present pain during palpation of the patella; have symptoms of insidious onset and lasting for at least 1 month; presenting the worst pain level in the previous month of at least thirty milimeters on the visual analog pain scale (VAS); score below 83 on the Previous Knee Pain Scale (AKPS) questionnaire	Women with a sign or symptom caused by any knee dysfunction; with a recent history of surgery within three months in this joint; history of patellar subluxation or clinical evidence of meniscal injury; ligament instability; osteoarthrosis in any lower limb joint; pathology in the patellar tendon or referred pain from the spine; neurological disease; inflammatory process or have recently undergone physiotherapeutic treatment (at least 6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8hc3zf	A clinical study to evaluate the safety and blood concentration of Melatonin sublingual in healthy male research participants	Not yet recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1960	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of Melatonin Sublingual Suspension, after a single dose in healthy male participants	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-09-10	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-8hc3zf	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50Kg and BMI less than or equal to 30Kg/m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; have participated in any experimental drug study within 1 year before starting the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-92dbtx	Attention to the health of the elderly in primary health care	Data analysis completed	Intervention	2018-07-05	<NULL>	<NULL>	1961	Attention to the health of the elderly: a proposal for multidimensional evaluation and intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-92dbtx	<NULL>	Age greater than or equal to 60 years; male or female gender; be enrolled in the Primary Health Care of your municipality; and present preserved cognitive status.	Major physical disability; cognitive impairment; residence time in your municipality less than six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-9gh6js	Comparison between two forms of electrical stimulation producing contraction in the force gain of the flexor muscles of the forearm of the non-dominant hand	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1962	Comparison between the Russian current and the Aussie current in the force gain of the flexor muscles of the non-dominant hand	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-9gh6js	<NULL>	Age range between 18-30 years; female and do not practice regularized physical activities.	History of skeletal muscle dysfunctions prior, acute inflammation in the region to be researched; metallic materials implanted in the arm to be examined; pregnant women; patients with heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-3m9d74	Study of the usefulness of treatment of fungal infections in children with cancer and compromise of their immunity	Data analysis completed	Intervention	2018-07-05	<NULL>	<NULL>	1963	Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia: a randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2013-07-01	Fondo Nacional de Desarrollo Cientifico y Tecnologico, Chile	Fondo Nacional de Desarrollo Cientifico y Tecnologico, Chile	https://ensaiosclinicos.gov.br/rg/RBR-3m9d74	<NULL>	"Children and adolescent with cancer; less or equal to 18 years of age; admitted because of a febrile neutropenia episode.
Informed consent of the parent or legal guardian
assent if older than 8 years of age."	"Children with hematopoietic stem cell transplant.
Children with cancer under voriconazole or posaconazole prophylaxis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-82m8cr	Training and strengthening of the abdominal and spinal muscles in individuals with knee inflammation	Recruitment completed	Intervention	2018-07-05	<NULL>	<NULL>	1964	Efficacy of an eccentric training protocol and core muscle strengthening in individuals with patellar tendonitis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-82m8cr	<NULL>	Age between 18 and 40 years; Have a medical diagnosis of patellar tendinitis; Present pain in the region of the patellar tendon; Agreement not to undergo any physical therapy or other rehabilitation procedure during the research period or less than six months; Agreement to not undergo any drug treatment during the research period.	Have undergone physiotherapeutic treatment or other rehabilitation procedure in the last six months; Present serious cardiovascular, respiratory, neurological and orthopedic diseases; Missing three consecutive appointments without prior notice to the research team.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-7n8vq5	Effects of elastic bands and laser treatment on hand strength with restriction of blood flow	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1965	Influence of elastic bandaging and laser on palmar grip strength in a blood flow restriction protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7n8vq5	<NULL>	Individuals of both sexes; age range between 18 and 30 years; Students of the Federal University of Santa Catarina-UFSC; Only those participants who are able to carry out the proposed activities will be selected.	Individuals with any type of injury to the forearm that compromise the integrity of the musculature; Fractures in the wrist and fingers, with pain in the upper limbs for any reason; obese; hypertensive; cardiopathy; cognitive deficit; manual workers, who do physical activities daily and take medication that interferes with the final results of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4fyhhy	Muscle Contraction during Hip strengthening Exercises	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1966	Comparison of the Activity of the Middle Buttock Muscles and Tensor of the Fascia Lata, during Exercises to Strengthen the Lateral Region of the Hip	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-16	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4fyhhy	<NULL>	Be between the age group between 18 and 30 years; women; with and without complaints of pain in the patellar femoral joint; the characterization of the sample will be through IPAQ, with individuals classified as sedentary or moderate.	Individuals with the IPAQ score equal to vigorous; presence of fractures in the last 6 months; muscle lesions or some rheumatologic pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-46gj9d	Evaluation of mass loss and muscular strength in hospitalized elderly	Not yet recruiting	Observational	2018-07-05	<NULL>	<NULL>	1967	Evaluation of Sarcopenia in hospitalized elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Estadual de Ponta Grossa	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-46gj9d	<NULL>	Elderly people from 60 years of age; hospital admission of up to 48 hours; hospitalization time equal to or greater than 5 days; previous functional independence report	Seniors who can not carry out the proposed evaluations; which have: peripheral saturation less than 85%, heart rate less than 50 or greater than 140bpm before evaluation; respiratory rate greater than 35 ipm, temperature greater than 38 ° C and blood pressure variation in 20% of the current (for more or less)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-6g4mj6	Bleaching efficacy with two protocols in adults	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1968	Bleaching efficacy of 35% and 38% hydrogen peroxide with two protocols in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6g4mj6	<NULL>	To be included in this study participants had to be aged 18 years or over and had good general and oral health; participants should have at least 6 anterior maxillary sound teeth; at least 1 shade C2 or darker central incisor as assessed by value-oriented shade guide (VITA classical, Vita Lumin, Vita Zahnfabrik, Bad Säckingen, Germany).	Participants with restorations on the labial surface of their anterior teeth and non-carious cervical lesions; with full crowns or veneers; gingival recession; teeth treated endodontically or with spontaneous tooth pain; with internal tooth discoloration; teeth that had fluorosis; pregnant or lactating or had bruxism habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4r6p5v	Effect of physical exercise and nutritional programs on the health status of schoolchildren aged 4 to 11 years old from Santo Antônio de Goiás	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1969	Metabolic syndrome: metabolic, oxidative and inflammatory responses of physical exercise and nutritional programs in schoolchildren aged 4 to 11 years old from Santo Antônio de Goiás	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-02	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4r6p5v	<NULL>	Be aged between 4 and 11 years old; both genders; to reside in Santo Antônio de Goiás; to be enrolled in the city elementary school.	Have cognitive or physical disabilities; have pathologies such as respiratory, cardiologic, renal or hepatic chronic diseases, which prevent data collection and vitamin D supplementation; being in use of any medication that influences the serum concentration of lipoproteins; have used cholecalciferol supplement in the last 10 weeks; serum 25-hydroxyvitamin D levels above 75 ng/dL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-5qywrf	Effectiveness of effect of relaxation therapy with guided imagery on anxiety and pain in patients undergoing stomach reduction surgery	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	1970	Relaxation therapy with guided imagery on anxiety and pain in patients undergoing bariatric surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5qywrf	<NULL>	Patient submitted to bariatric surgery by videolaparoscopy.	Patient who presented hearing deficit or alterations; patient who was not in a position to maintain dialogue with the researcher after the end of the effects of anesthetic drugs and patient who received preanesthetic and / or anxiolytic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-366zkv	Clinical efficacy and dental sensitivity generated by hydrogen peroxide and carbamide in the office bleaching technique	Recruitment completed	Intervention	2018-07-06	<NULL>	<NULL>	1971	Clinical efficacy and dental sensitivity generated by hydrogen peroxide and carbamide in the office bleaching technique: a controlled, blinded, split-mouth clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-366zkv	<NULL>	Patients should be at least 18 years of age; good general and oral health; the 10 teeth should be present in each hemiarcate; be able to return for periodic appointments; have teeth that will be bleached free of cords; without restorations; have never been cleared before	Those who present restorations on teeth that will be bleached; have some serious pathology in the oral cavity; are pregnant or breastfeeding; have severe internal tooth discoloration; or have bruxism; a patient with chronic illness; excessive or severe calculus on the sites studied; root exposition on the teeth to be cleansed; presence of cracks in the teeth to be cleansed; users of drugs; users of alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8m8v2x	Effects of Hammock Method in incubator on pain, sleep state and heart rate of premature newborns admitted to the Neonatal Intensive Care Unit	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1972	Effects of Hammock Method on pain, sleep state and physiological variables of newborns admitted to the Neonatal Intensive Care Unit	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8m8v2x	<NULL>	Patients hospitalized at the Neonatal Intensive Care Unit of a university hospital; considered  premature;  with gestational age less than 37 weeks; up to 60 days of age; clinically stable.	clinical instability; heart rate bigger then 180 beats per minute or less than 100 beats per minute; respiratory rate bigger than 60 breaths per minute or  less than 40 breaths per minute; SpO2 less than 89%; infants needing ventilatory support; presence of infectious process; use of phototherapy; neurological problems and congenital facial malformations that would not allow the application of the Pain Assessment Scale NIPS, as well as the Sleep State Assessment Scale and Adapted Vigilance of Brazelton.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-7zh8x7	Effects of Juice Fortification with Iron and Zinc in children	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1973	Iron and Zinc Fortification effects on the Hemoglobin Level of preschool and school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-25	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7zh8x7	<NULL>	Children from 0 to 17 years of age; both sexes; enrolled at the institution Reino da Garotada de Pos.	Individuals who are taking or have taken vitamin and/or mineral supplementation for the last two months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-2yzs76	Multidisciplinary Program of Treatment of Obesity: Evaluation of Cardiometabolic Risk Factors	Recruiting	Intervention	2018-07-06	<NULL>	<NULL>	1974	Effectiveness of a Multidisciplinary Program in Evaluation of Cardiometabolic Risk Factors and Treatment of abdominal Obesity in two cities in the Northwest of Paraná	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-20	Universidade Estadual de Maringá	Universidade Estadual do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2yzs76	<NULL>	Age between 18 and 50 years; Being overweight or obese, from cutting index points Body mass index greater than or equal 25; Waist circumference greater than or equal 88 cm for women and greater than or equal 102 cm for men; Be resident in Maringa or Maringá metropolitan area; Present willingness to participate in the evaluations of the risk cardiometabólico; Agree and sign the informed consent approved by the local Ethics Committee.	"Recent abdominal surgery or Bariatric Surgery;
Pulmonary disease with oxygen dependence; Hospitalization for treatment of cardiovascular diseases in the last 6 months; Aortic stenosis;
Being pregnant or have less than 3 months post partum; Use of medicines for weight loss; Using glicocorticoides;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8wrtq9	The benefits of exergames in the variables related to health	Not yet recruiting	Intervention	2018-07-09	<NULL>	<NULL>	1975	Effects of physical training with exergames in physiological and psychobiological variables health related	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Educação Física e Danca - Universidade Federal de Goiás	Faculdade de Educação Física e Danca - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8wrtq9	<NULL>	Age between 18 and 30 years.not involved in strength training programs.body mass index (BMI) of less than or equal to 25.0 kg / m².	Contraindication for performing physical activity assessed by the physical activity readiness questionnaire (PAR-Q).illiterate. regular use of alcoholic beverages and tobacco. orthopedic, metabolic, respiratory and/or neurological diseases and/or limitations that prevent physical activity.absence in more than 15% of the sessions.disease that has repercussions on mood disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-7j75q5	The effect of intraoperative replacement solutions with hydroxyethylstarch and lactated ringer on renal function in patients undergoing abdominal uterine removal surgery	Recruitment completed	Intervention	2018-07-09	<NULL>	<NULL>	1976	Effects of intraoperative volume replacement with hydroxyethylstarch and lactated ringer on renal function of patients undergoing open hysterectomy: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-03	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7j75q5	<NULL>	Healthy volunteers; female; preserved renal function; open abdominal hysterectomy; general anesthesia;	Patient refusal; altered renal function; use of diuretics; obesity; decompensated hypertension; decompensated diabetes mellitus;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-8xt8wx	Root canal treatment in primary molars with necrotic pulp using two different pulp therapies	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1977	Pulp therapy in necrotic primary molars using CTZ paste and Zinc Oxide-Eugenol paste - a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8xt8wx	<NULL>	Lower primary molars with clinical and / or radiographic history of pulp necrosis. Crown with sufficient dental structure to be restored with stainless steel crown. Rhizolysis equal to or less than 1/3	Teeth that present calcium metamorphosis. Pathological root resorption. Coronary destruction that makes it impossible for the tooth to be restored. You have been using antibiotics for the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3sqsh8	Evaluation of the inflammation and effects of dental denture during orthodontic treatmen	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	1978	Evaluation of inflammatory activity and efficacy of dental bleaching during orthodontic treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	Centro Universitário do Maranhão	Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3sqsh8	<NULL>	Patients aged between 18 and 40 years will be included; who agree and sign the informed consent form (TCLE); with good oral health in general, with the presence of all upper teeth up to the first molar with vitality, free of caries lesions; and may have satisfactory aesthetic restorations, proven by periapical radiographs that do not involve the middle third of the dental crown; without cervical lesions (abrasion, erosion and abduction); absence of periodontal disease; have not undergone periodontal treatment within 3 months prior to the start of the study; do not present clinical signs of gingivitis and do not have systemic disorders that interfere with the periodontal condition, prior to the installation of the device; non smokers; have not undergone previous orthodontic treatment; have not used antibiotics in the 3 months prior to the study; not being on systemic medication; the initial color of the teeth should be A2 or darker by comparison with the Vita Classic scale (Vita Zahnfabrik, Bad Säckingen, Germany) organized in order of value	The study will exclude patients who had undergone tooth whitening treatment in the last 12 months; with caries, cervical lesions; pregnant or lactating women; root canal treatment; patients with restorations at buccal surface or dental prosthesis on the teeth; gingival recessions; parafunctional habits; patients who were taking medications with an analgesic or anti-inflammatory effect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-9zftgs	Analysis of patient parameters related to oxygen therapy in patients undergoing anesthesia recovery	Data analysis completed	Intervention	2018-07-09	<NULL>	<NULL>	1979	Analysis of the Aldrete Kroulik scale related to oxygen therapy in patients undergoing anesthesia recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Minas Gerais - Escola de Enfermagem	Hospital das clínicas da UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9zftgs	<NULL>	Adult, age between 18 and 64 years; Classification of American Society of Anesthesiologists (ASA) 1 or 2; elective anesthetic-surgical procedure; general anesthesia; general conventional surgery; Peripheral oxygen saturation greater than or equal to 95% upon entering the Post Anesthesia Recovery Room.	Comorbidities of the respiratory system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3wfshm	The effect of Low Intensity Laser on Nipple Traumas	Recruitment completed	Intervention	2018-07-09	<NULL>	<NULL>	1980	"Mammillary traumas during breastfeeding and the action of low intensity laser:
Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Universidade Estadual de Londrina/UEL	Universidade Estadual de Londrina/UEL	https://ensaiosclinicos.gov.br/rg/RBR-3wfshm	<NULL>	Being breastfed; Age equal or superior to 18 years; Protactile nipples with presence of pain and trauma in the nipple-aréolar region No use of any topical agent, shell or silicone intermediate in the breasts Be resident in the urban area of the municipality	Previous history or presence of malignant pathologies in the breasts; Presence of pacemaker;Reporting of photosensitivity or any adverse reactions to exposure to sunlight; Presence of cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-72zvxv	Nutritional intervention through a digital game based on the Food Guide for the Brazilian Population aimed at adolescents of the Federal District	Recruitment completed	Intervention	2018-07-09	<NULL>	<NULL>	1981	Nutritional intervention for the implementation of the Food Guide for the Brazilian Population with mobile health among adolescents of the Federal District	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-21	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-72zvxv	<NULL>	Healthy adolescents from the first grade of private schools of the Federal District; both genders; with an expected age between 14 and 17 years-old	No signature or agreement of participation in the study by the adolescent or his or her responsible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-6q6ck3	The Upward and Downward Body Position of the Belly and the development of the premature child	Data analysis completed	Intervention	2018-07-09	<NULL>	<NULL>	1982	Influences of Body Position on the motor development of preterm infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-17	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-6q6ck3	<NULL>	Preterm infants; born with under 37 weeks of pregnancy; in the city of Franca, and the beginning of high risk ambulatory monitoring in Franca`s  public health system.	The preterm infants (equal or &gt; 37 weeks); infant that have attended only the private health system; infants  that are already in process in high risk ambulatory in the public health system; and that ones that didn`t accepted the terms of participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-387v6v	Influence of the dietary period (with restriction versus time restriction) on body composition, resting metabolic rate, hunger sensation, insulinemia, leptinemia and thyroid function of obese women submitted to diets with the same energy deficit.	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1983	Influence of the dietary period (with restriction versus time restriction) on body composition, resting metabolic rate, hunger sensation, insulinemia, leptinemia and thyroid function of obese women submitted to diets with the same energy deficit.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Alagoas	Centro de Recuperação e Educação Nutricional	https://ensaiosclinicos.gov.br/rg/RBR-387v6v	<NULL>	Women; adults (19-44 years old); obese (defined as a Body Mass Index&gt; 30 kg / m²); who are willing to lose weight; who have been weight-stable for at least 1 month at the time of inclusion.	individuals using chronic medicine (anti-diabetic, antihypertensive, antiretroviral, immunosuppressive, diuretic); with a pacemaker; that present edema and/or ascites; pregnant or lactating and has not performed any surgical intervention for weight management.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3jj84f	Hygiene of total dentures in patients leaving in home care facilities	Recruiting	Intervention	2018-07-10	<NULL>	<NULL>	1984	Controled randomized clinical trial of hygiene of complete dentures in institutionalized patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3jj84f	<NULL>	60 years of age or older; complete edentulism; use of a conventional upper complete denture in acrylic resin for at least one year	The wear of conventional upper fractured, repaired or relined upper dentures; being in use or having used antibiotics, antifungals or corticosteroids for a period of three months prior to the study; using denture adhesives; being a smoker; using of prostheses with excessive accumulation of calculus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-4vtsxb	Influence of genetic risk APOE on cognitive processing of elderly with Alzheimer&apos;s disease and healthy elderly	Not yet recruiting	Observational	2018-07-10	<NULL>	<NULL>	1985	Influence os Apoe genotype on event related potentials (ERP-P300) of elderly Alzheimer&apos;s disease and healthy elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4vtsxb	<NULL>	"Healthy elderly: present preserved cognition as evaluated by the Mini-Mental State Examination. No diagnosis of depression or clinically relevant depressive symptoms assessed through the Geriatric Depression Scale (GDS-30). Elderly people without cognitive impairment and who are able to perform ERP-P300 evaluation. Not have reported any neuropsychiatric disease.
Elderly with Alzheimer&apos;s disease: Clinical diagnosis of AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Stages between mild and moderate according to the Clinical Dementia Rating (CDR). Elderly who are able to perform ERP-P300 evaluation. Not have reported other neuropsychiatric disease."	Advanced stage of Alzheimer&apos;s disease. Do not permormed ERP-P300.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3h2xcn	Antioxidant effect of carqueja infusion in climacteric women	Recruitment completed	Intervention	2018-07-10	<NULL>	<NULL>	1986	Evaluation of the antioxidant activity of Baccharis trimera infusion (Less.) Dc. in climacteric women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3h2xcn	<NULL>	Women will be included who accept to participate in the research through the signing of the Free and Informed Consent Form, TCLE. Adhere for three months to treatment with Baccharis trimera infusion. Perform all stages of research protocol evaluations.	Women will be excluded the following drug classes are in continuous use: Hormone Replacement Therapy, HRT or who have previously had this treatment; vitamin supplement, medications for HAS, DM. Women who use medicinal plants on an ongoing basis;Women with low acceptability of Baccharis trimera infusion; Women who participated in the last 6 months of research with herbs, herbal medicines and functional foods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-4pt72m	Combination of physical exercises and training in video games for post stroke people	Recruiting	Observational	2017-01-24	<NULL>	<NULL>	1987	Combination of multimodal physical exercises in real and virtual environments for individuals after chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4pt72m	<NULL>	Chronic phase stroke; territory of the Cerebral Media or in the Anterior Cerebral Artery; both types of stroke (ischemic and hemorrhagic); cognition greater than 24 points in the Mini Mental State Examination; to less than 2 months of use in forms and the Wings of Empowerment with physical exercises; (community) and without experience in Virtual Reality games.	Individuals with any type of cardiovascular complication that would contraindicate physical exercise; who underwent surgeries to attenuate clinical conditions resulting from stroke; that had a chemical blockade to reduce spasticity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-83qw93	Evaluation of postoperative bleeding of oral surgeries in patients taking oral anticoagulants.	Recruiting	Intervention	2018-07-10	<NULL>	<NULL>	1988	Postoperative oral surgery bleeding in patient using anticoagulants: clinical randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-83qw93	<NULL>	Patients taking oral anticoagulants for at least 14 days; patients with indication of small oral surgeries; patients with INR (International Normalized Norm) between 1.5 and 4.0 the day before the procedure.	Patients with blood dyscrasia or other conditions that alter blood clotting; patients smokers; diabetic patients; pregnant or lactating patients; patients with a history of allergy to tranexamic acid or reabsorbable collagen gelatin; patients using medications that may interact with medications used in this study; oral surgeries that last 40 minutes; oral surgeries with large osteotomies (third molars included and impacted); patients with INR above 3.5	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-92qgnb	Comparison between two types of implants in patients with a history of aggressive periodontitis	Not yet recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1989	Comparison between two implant surfaces in patients with a history of aggressive periodontitis: randomized, controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92qgnb	<NULL>	Older than 21 years; Need for rehabilitation of at least two dental elements with two dental implants, located in the same arch; Systemically healthy, without contraindications to oral surgical procedures; Proper oral hygiene (bleeding on probing less than 20%; plaque index less than 20%); Aggressive Periodontitis already treated; Signature of the free and informed consent form.	Pregnancy or lactation; Existence of metabolic bone disease; Use of drugs that influence bone metabolism; Use of bisphosphonates in the last 4 years; History of malignant tumor, radiotherapy or chemotherapy in the last 5 years; Smokers (greater than 20 cigarettes/day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-5dnsj7	Influence of a Balance Protocol on the gross motor function of children with Cerebral Palsy	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1990	Influence of a Balance Protocol on the gross motor function of children with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Associação de Assistência a Criança Deficiente	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5dnsj7	<NULL>	Children with Cerebral Palsy of spastic diparesia type; classified in level III of the GMFCS with age between 4 and 8 years and 11 months.	Patients who were unable to understand the proposed activities, underwent orthopedic surgery less than 12 months; and peripheral blocks less than six months old and who presented clinical intercurrences that could interfere with the rehabilitation process were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-66jx3m	Effect of resistance training on balance and muscular strength of the elderly	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1991	Assessment of the balance and muscular strength of the elderly before and after resistance training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-09	Universidade Federal do Pampa	Universidade Federal do Pampa	https://ensaiosclinicos.gov.br/rg/RBR-66jx3m	<NULL>	"Volunteers of both genders, aged 60 or
over, ability to stand and walk
independently"	"Volunteers who have any type of
amputation, no independent gait, body mass index (BMI) below 18.5 kg / m2; have been engaging in physical activity in the past 6 months
uninterrupted; hypertensive or with blood pressure values greater than 180mmHg
systolic and diastolic blood pressure
90 mmHg"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3dznfh	Effect of social media on oral hygiene habits in children	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1992	Impact of social media on oral hygiene habits in children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3dznfh	<NULL>	Guardians that authorized the participation of the scholar in the study through the signing of the Free and Informed Consent Form; scholars who signed the Consent Form and that were enrolled in the sixth to the ninth grade in the School of Application of UFSC; scholars who used fluoride toothpaste and had a Smartphone with the WhatsApp Application	Dental caries with repercussions in the pulp; scholars with orthodontic devices; with systemic diseases; and with learning disabilities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-3zjn27	The efficacy of Pharyngeal Packing during adenotonsillectomy in children	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1993	The efficacy of hypopharyngeal packing during adenotonsillectomy in children in the prevention of postoperative nausea and vomiting.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-28	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3zjn27	<NULL>	"Children aged between 4 and 12 years old;A
adenotonsillar hipertrophy; adenotonsillectomy indication for treatment of Apnea Obstructive Syndrom ou Recurrent Tonsilitis, caregiver able to give informed consent and to complete de Patient Diary reliably."	Patients with hematopoietic, cardiovascular, hepatic, kidney, neurological, psychiatric, autoimmune disease; patients that feel unable to complete the Patients´Diary.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-8grbsz	Effect of the application of previous ischemia on pain sensitivity and aerobic metabolism.	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1994	Effect of ischemic preconditioning on aerobic metabolism and pain sensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-16	Centro de Ciências da Saúde e do Esporte - UDESC	Centro de Ciências da Saúde e do Esporte - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8grbsz	<NULL>	Healthy volunteers; both sexes; non smokers; age between 18 and 40 years;	Regular use of any type of medication; smokers; osteo-articular lesion in the last twelve months;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5t582g	Comparison of Body warming devices and clinical outcomes after Heart Surgery: randomized Clinical Trial	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1995	Comparison of Cutaneous Warming Devices and clinical outcomes in the postoperative period in Cardiac Surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-5t582g	<NULL>	Age 18 years or older; submitted to elective coronary artery bypass grafting with Cardiopulmonary bypass;  Intensive Care unit admission temperature below 36 ° C and greater than 32 ° C.	Other surgical corrections associated with coronary artery bypass grafting with Cardiopulmonary bypass; use of circulatory support devices, intra-aortic Balloon Counterpulsation; extracorporeal membrane oxygenation ; ventricular percutaneous circulatory assistance previus cardiac surgery; patients with chronic renal disease; intraoperative cardiac arrest, immunosuppressed patients; acquired or hereditary coagulation disorders; liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-825cgv	Effect of Exercise Program in Group and Home-Based Exercise on the Functionality of pre-frail Elderly	Recruitment completed	Intervention	2018-07-11	<NULL>	<NULL>	1996	Effects of the Group and Home Based Exercise Program on the Functionality of pre-frail Elderly	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-825cgv	<NULL>	Women; age from 60 years; frailty detected through validated phenotypic criteria proposed by Fried et al	Elderly women with 3 or more frailty criteria proposed by Fried et al;  with medical  restrictions to physical activity; participating on exercise program in last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5fsg97	Effects of integrative therapies in health, quality of life and wellness of breast cancer women and prostate cancer men	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1997	Effects of the Brazilian integrative wellness protocol for cancer care on quality of life, wellness, and biopsicosocial factors of breast cancer women and prostate cancer men	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	https://ensaiosclinicos.gov.br/rg/RBR-5fsg97	<NULL>	Breast cancer women; prostatic cancer men; adults; in any cancer and treatment stage.	Open lesions or  wounds; recent surgeries (less than thirty days); severe immunodeficiency ( neuthrophil count less than 500 cells per / ml).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4h2cr6	Exercises to improve shoulder movement Individuals with Shoulder Dysfunction	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1998	Efficacy of an Exercise program for Scapular Dyskinesis in individuals with Shoulder Impact Syndrome	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4h2cr6	<NULL>	Individuals diagnosed with shoulder impact syndrome; Individuals who present scapular dyskinesis identified in the dynamic exam of upper limb flexion using the simple &apos;yes&apos; or &apos;no&apos; test; Aged between 18 and 50 years; Neer positive test; Hawkins Kennedy positive test;	Have surgery on the shoulder; Neoplasms or infections; Neurological disorders;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-7528x4	Comparison of the effect of Hypnosis and Electrostimulation on pain control in patients with Chronic Low Back Pain	Recruiting	Intervention	2018-07-12	<NULL>	<NULL>	1999	Comparison of the effect of two analgesic techniques on pain control in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7528x4	<NULL>	Chronic low back pain	are performing physiotherapeutic treatment by electroanalgesia, regardless of the current used; having a cardiac pacemaker; pregnant women; individuals who have performed surgical procedures in the spine; individuals who use analgesic drugs twenty-four hours (24 hours) before the interventions; individuals who present contraindication to cold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5d4s4f	Effect of therapies combination to healing of venous ulcers, leg pain and self rated health and quality of life of patients in a six month follow-up	Recruitment completed	Intervention	2018-07-12	<NULL>	<NULL>	2000	Effectiveness of interdisciplinary and multidimensional technologies in the healing of venous ulcers, leg pain and self rated health and quality of life of patients in a six month follow-up in primary care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de Goiás	Fundação de Amparo à Pesquisa do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5d4s4f	<NULL>	Being 18 years of age or older; scoring normal on Mini Mental State Exam, considering education level; presenting a leg ulcer with clinical signs of impaired venous circulation with ou without the low impairment of arterial circulation	People with liver disease, people with kidney disease, people who present no palpable peripheral arterial pulses, preventing the verification of ankle arm index (AAI); people who had an AAI less than 0.8 or greater than 1.3, or intermittent claudication when walking 250 meters or less which fades at rest, or paleness on elevation of the affected limb, even with AAI within the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-9p4f7d	needling technique and myofascial release in the treatment of neck and shoulder trigger point	Data analysis completed	Intervention	2018-07-12	<NULL>	<NULL>	2001	Acute eficcacy of dry needling versus myofascial pressure release in neck and shoulder trigger points: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-02	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9p4f7d	<NULL>	Adults aged 18 to 60 years old with chronic neck pain and symptoms lasting for at least twelve weeks; presenting with myofascial trigger point in only one upper trapezius muscle.	history of upper quadrant surgery; non-myofascial disorders, presence of myofascial trigger point bilaterally in the upper trapezius muscle; complaints of pain or injuries around the elbow or forearm; having received treatment for neck pain within the past twelve weeks; rariculopathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-3chymm	Physiotherapeutic treatment in people who underwent hip replacement surgery	Data analysis completed	Intervention	2018-07-12	<NULL>	<NULL>	2002	Comparison between two physiotherapeutic rehabilitation methods in individuals submitted to total hip arthroplasty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-30	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3chymm	<NULL>	Age between 50 and 90 years; performed ATQ due to OA; four to five weeks postoperatively; who are not enrolled or participating in another physiotherapeutic treatment program; reside in Campo Grande or region.	History of stroke; Parkinson&apos;s disease; gait disturbances of neurological origin; clinical depression or disease that compromises the level of cognition; revisions of CKD, postoperative complications such as infection or dislocation; cardiopulmonary contraindications to perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-683rjr	Evaluation of Neural Scar After Neck Surgery in Thyroid Cancer	Recruitment completed	Intervention	2018-07-12	<NULL>	<NULL>	2003	Post-operative Lateral Neck Dissection Management of Cervical Traumatic Neuromas in Patients with Thyroid Carcinoma	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	Instituto do Câncer do Estado de São Paulo - ICESP	Instituto do Câncer do Estado de São Paulo - ICESP	https://ensaiosclinicos.gov.br/rg/RBR-683rjr	<NULL>	patients with thyroid cancer who underwent to lateral neck dissection; ultrasound study evidencing nodular image in the third level neck compartment with suspected features of neuromas: oval shape; heterogeneous texture; no vascularity at color Doppler study; rigidity on elastography;	age &lt; 18 year-old; active anticoagulant treatment; malignant biopsy-proven specimens; pregnancy and breast-feeding;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4y4k7w	Effect of the follow-up of brief interventions for the use of alcoholic beverages and cigarettes in pregnant women: a randomized clinical trial	Recruitment completed	Intervention	2018-07-13	<NULL>	<NULL>	2004	Effect of monitoring of Brief Interventions for Alcohol and Tobacco use in pregnant women: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-06	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4y4k7w	<NULL>	pregnant women registered in said services; be 18 years old or over and sign the Free and Informed Consent Form.	Not receiving all the planned interventions for the study allocation group; refuse to participate in any stage of the research; being in the eighth or ninth month of gestation at the time of the recruitment of the participants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-25w6kk	Exercises to improve posture,flexibility and quality of life in1o to 13 year-old females	Recruiting	Intervention	2018-07-13	<NULL>	<NULL>	2005	The comparison of the effect of Holistic Gymnastics, Eutonia and Pilates on posture, flexibility and quality of life of children between 10 and 13 years old	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-25w6kk	<NULL>	"Age between 10-13 years;
Female gender;
Tosign the informed Consent Form (ICF)"	"sequel of orthopedic, rheumatic or neurological disease;
use of prosthetic limbs;
pain during practice of physical activities"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4nj799	Product development based on Ora-pro-nobis and its influence on feces, blood tests and anthropometric data in Adult Men	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2006	Product development based on Ora-pro-nobis (Pereskia aculeata Mill.) and its influence on the intestinal microbiota, antioxidant capacity, anti-inflammatory, biochemical and anthropometric parameters in Adult Men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4nj799	<NULL>	Men between the ages of 20 and 50; Body mass index greater than or equal to 25 kg / m² and less than 40 kg / m²; Not having participated in a weight loss program in the last six months; Be healthy	History of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; restrictive diet practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-9nt9hv	Text Messages to improve HIV Antiretroviral Therapy Compliance	Recruiting	Intervention	2018-07-13	<NULL>	<NULL>	2007	The use of Text Messages in adherence to Antiretroviral Treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-11	Universidade Federal de Santa Maria	Hospital Universitário de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9nt9hv	<NULL>	The inclusion criteria for participation in the study will be: people infected with HIV and on antiretroviral treatment; Be on medication for at least 3 months; (15 years or older), according to UNAIDS criteria.	"The exclusion criteria will be: to present some cognitive and mental limitation (which impairs comprehension and / or verbal expression); To be in prison, a
Access to mobile phones; Not knowing how to read if the person does not use tools that allow the reading of the message, since the intervention will be carried out by means of a text message; Women in the gestational period, since there is evidence that during this period there is an increase in adherence."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-7cxwg5	Use of ultrasound in disinfection during  root canal treatment	Recruitment completed	Intervention	2018-07-13	<NULL>	<NULL>	2008	Passive x Continuous Ultrasonic Irrigation in primary endodontic infections: action in the present microbiote, endotoxins and imflamatory profile	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-06-12	ICT - Universidade Estadual Paulista Júlio de Mesquita Filho	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7cxwg5	<NULL>	Patients in adulthood; Need for endodontic treatment; Permanent teeth with primary endodontic infection; Unirradicular; Presence of a single canal and periapical lesion; Absence of periodontal pockets greater than 4 mm; No mobility	Teeth that can not be insulated with the rubber dam; With root fracture; Exposure of the pulp chamber; Patients who have used antibiotics or antifungals in the last 3 months; Patients with systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-2nfy5q	The effect of selenium supplementation through Brazil nut consumption on inflammation, free radicals production and the expression of a protein that have this mineral and of microRNAs in obese women	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2009	Effect of selenium supplementation with Brazil nut (Bertholettia excelsa H.B.K.) on inflammation, oxidative stress and selenoprotein P and microRNAs expression in obese women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2nfy5q	<NULL>	BMI from 28.0 to 39.9 kg/m²; do not be pregnant or participating in another clinical trial; do not use vitamin-mineral supplements; do not smoke or drink alcohol chronically; do not practice intense physical activity; do not present food allergy to nuts or report a regular consumption of Brazil nuts.	Present recent infections, high-grade inflammation, chronic cardiovascular and gastrointestinal diseases (inflammatory bowel disease, celiac disease), and cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-8dqrdq	Training of respiratory muscles on functional variables and cardiac function in patients undergoing a bypass graft	Recruiting	Intervention	2018-07-16	<NULL>	<NULL>	2010	Individualized inspiratory muscle training on functional and ecocardiographic variables in patients submitted to myocardial revascularization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Instituto Nobre de Cardiologia	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-8dqrdq	<NULL>	Age between 30 and 60 years; Both genders; Undergoing myocardial revascularization, this procedure being done via median sternotomy and extracorporeal circulation.	Do not understand how the proposed techniques are performed; Have hemodynamic instability during inspiratory muscle assessment or training; Physical limitation, such as amputation, that compromises functional capacity assessment; Change in cognitive ability, assessed through the Confusion Assessment method for the ICU (CAM-ICU), to answer the questionnaires; Impossibility of echocardiogram repetition by the same physician; They did not agree to sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-2pcrzy	Restorative treatments for teeth with Hipomineralization of Molars and Incisors	Recruiting	Intervention	2018-07-16	<NULL>	<NULL>	2011	Therapeutic modalities in Hipomineralization of Molars and incisors: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-05	Universidade Federal do Paraná	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2pcrzy	<NULL>	Children residing in the municipality of Curitiba; present first permanent molars hypomineralization of molars and incisors MIH.	present fluorosis; tooth that requires endodontic treatment; children with orthodontic appliance; impossibility of absolute isolation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-42zsbt	Use of whey protein , vitamin D and  training in  older adults nursing home.	Data analysis completed	Intervention	2017-03-31	<NULL>	<NULL>	2012	Whey protein supplementation, vitamin D and resistance training in institutionalized older adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade do Extremo Sul Catarinesnse	Universidade do Extremo Sul Catarinesnse	https://ensaiosclinicos.gov.br/rg/RBR-42zsbt	<NULL>	Permanent residence in the institution; be able to understand instructions in Portuguese and able to understand, accept and sign the Consent Form.	Older adults people with unstable disease and or terminal stage; impaired cognitive ability as assessed by (Mini-Mental State Examination, score &lt;24 points); hemiplegia impeding participants to use resistance training equipment; Parkinson&apos;s disease; permanently in wheelchairs or bed; or older adults who have performed resistance exercises; or regularly consumed a protein or vitamin D supplement in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-9mrbrf	Using video laryngoscope for intubations in pediatric emergency	Recruitment completed	Intervention	2018-07-16	<NULL>	<NULL>	2013	Changing the view: video laryngoscope for intubations in pediatric emergency	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-23	Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9mrbrf	<NULL>	Children intubated in the emergency department; both genders; age between 1 and 18 years old	Children younger than one year; adolescents older than 18 years;another device other than laryngoscope or videolaryngoscope used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5kw3bz	Effect of tumeric extract supplementation on oxidative stress and inflammation after running	Data analysis completed	Intervention	2018-07-16	<NULL>	<NULL>	2014	Effect of Curcula longa L. supplementation on oxidative and inflammation markers after endurance exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-08	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5kw3bz	<NULL>	Men, eutrophic, aged between 25 and 50 years, amateur runners	Participants on weight loss diet/medication, diagnose with any acute or chronic diseases, taking medication that could affect the immune system, injured, smokers, and with a history of chronic alcoholism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-92sp94	Physiotherapy for pregnant women	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2015	"Pregnant Healthy:
physiotherapeutic attention to pregnant woman in primary care"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-92sp94	<NULL>	Pregnant women with ages ranging from 18 to 40 years. Between the 9th week and 32 weeks of gestation. Do prenatal care at the school&apos;s health center	Pregnant women who have some gestational risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3y4bdk	Evaluation of brain and muscle activity in recovery of impaired upper limb after stroke	Data analysis completed	Intervention	2018-07-17	<NULL>	<NULL>	2016	Evaluation of central and peripheral excitability in individuals submitted to neurological rehabilitation for the paretic upper limb after Stroke	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3y4bdk	<NULL>	Clinical diagnosis of stroke; Chronic phase of the stroke; presence of left or right hemiparesis; both sexes; age greater than 18 years; present mental competence and present at least 10 degrees of wrist extension	Individuals with hemiplegia or severe spasticity, degree of severe neurological impairment; in the use of a myorelaxant drug and to have applied botulinum toxin in the muscles of the paretic upper limb for less than six months of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-4bhr78	Effect of clinical reasoning prompts for nursing students	Not yet recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2017	Effect of clinical reasoning prompts on the diagnostic accuracy of baccalaureate nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Escola Paulista de Enfermagem	Departamento de Enfermagem da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4bhr78	<NULL>	Be a student of the baccalaureate course in Nursing; Have completed and have been approved in the subjects of Fundamentals of Nursing Care, Clinical Nursing and Surgical Nursing of EPE / UNIFESP; or have completed the disciplines of Fundamentals of Nursing Care and Nursing in Adult Health and the Elderly of UFPR.	Medical diagnosis of dyslexia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3xbnnn	Endodontic treatment versus retreatment: inflammatory and microbiological evaluation, before during and after 18 months of treatment	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2018	Primary versus secondary endodontic infection: inflammatory and lipid profile, microbial profile, endotoxin and LTA levels before and during endodontic therapy and success after 18 months of treatment	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-07-12	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xbnnn	<NULL>	Patients in adulthood; Need for endodontic treatment; Permanent teeth with primary endodontic infection; Unirradicular; Presence of a single canal and periapical lesion; Absence of periodontal pockets greater than 4 mm; No mobility.	Teeth that can&apos;t be insulated with the rubber dam; With root fracture; Exposure of the pulp chamber; Patients who have used antibiotics or antifungals in the last 3 months; Patients with systemic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-2t3hfv	Evaluation of the Efficacy of Transcranial Direct Current Stimulation in the Treatment of Cognitive Symptomatology in the Early Stages of Psychosis	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2019	Evaluation of the Efficacy of Transcranial Direct Current Stimulation in the Treatment of Cognitive Symptomatology in the Early Stages of Psychosis: Study Protocol of a Double-blind Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-16	Universidade Federal de Sao Paulo - UNIFESP	Universidade Federal de Sao Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-2t3hfv	<NULL>	Subjects of both genders, diagnosed with schizophrenia in early stage psychosis (first five years of illness), confirmed through the Structured Interview of the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders - 5th edition (SCID-5); aged 18-60 years; minimum of 4 years of education;  Intelligent Quotient (IQ) from low average to higher scores (IQ&gt;70); and the subjects should be receiving stable doses of antipsychotics for at least four weeks (antipsychotic dose stability criterion).	(1) presence of a history of cranioencephalic trauma with loss of consciousness with a time greater than 5 minutes; (2) history of central nervous system diseases that affect the brain; (3) unstable clinical conditions; (4) use of drugs that affect cognitive performance such as benzodiazepines and anticholinergic agents; (5) current diagnosis of substance abuse; (6) history of substance dependence in the last 6 months, except nicotine addiction; (7) current diagnosis of another Axis I condition, confirmed through SCID-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-8nbnc4	Evaluation of a program of physical activity in student health	Data analysis completed	Intervention	2018-07-17	<NULL>	<NULL>	2020	Evaluation of the effect of a physical activity program on aerobic fitness and cardiovascular risk markers in schoolchildren	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8nbnc4	<NULL>	Healthy volunteers; both genders, aged between 9 and 15 years.	Volunteers who can not perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-86hhb7	The effect of Hand Therapy on quality of life, improvement of pain, function and psychic conditions of patients with shoulder pain	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2021	The effect of Manual therapy on the quality of life, funcionality and psychic condition of patientes with Shoulder Impact Syndrome	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus Botucatu	Centro de Fisioterapia e Saúde	https://ensaiosclinicos.gov.br/rg/RBR-86hhb7	<NULL>	Diagnostic confirmation by clinical examination or image examination; Neer positive test; Hawkins test positive; pain during resistive isometric abduction; pain during passive or isometric lateral rotation resisted; pain during active shoulder lift; pain in the palpation of the rotator cuff tendons and pain in the region of the C5 and C6 dermatome	Age less than 40 years; bilateral pain; pregnancy; systemic pathologies; physiotherapy for less than 6 months prior to assessment; signs of total rupture or acute inflammation of the rotator cuff; cervical spine related symptoms; glenohumeral joint instability; fracture history or surgery on the affected limb and adhesive capsulitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5npmgj	Educational video to teach deaf people how to rescue someone who has had a cardiac arrest: construction, validation and evaluation	Recruitment completed	Intervention	2018-07-18	<NULL>	<NULL>	2022	Educational video for deaf people about basic living support: construction, validation and evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-17	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5npmgj	<NULL>	Be enrolled in any of the schools in which the data was collected; and have no illness or limitation that would make it impossible to watch the video or expository classroom	Have leave foreseen for the next 15 days (since the post test was also applied 15 days after the educational interventions); not complete the data collection instrument and do not have the physical conditions to participate in the practice of cardiopulmonary resuscitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7zdk7k	Functional and pain evaluation of people with Haemophilia	Not yet recruiting	Observational	2018-07-18	<NULL>	<NULL>	2023	Algofunctional evaluation of people with Haemophilia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7zdk7k	<NULL>	Diagnosis of moderate or severe A or B haemophilia;individuals aged between 18 and 60 years of age;subjects in follow-up with the multidisciplinary team at the Haemophilia Orthopedics outpatient clinic at CHC-UFPR; individuals who have had the infusion of clotting factor VIII or IX immediately prior to the evaluation;be able to understand verbal command and carry out the proposed evaluations;being prophylaxis with coagulation factor VIII or IX between 2-3 times per week as prescribed by the hematologist;individuals who agreed to participate in the study by signing the free and informed consent form.	"Diagnosis of others coagulopathies; not within the age range specified above; patients who have undergone an orthopedic surgical procedure for arthroplasty; who do not perform prophylaxis with factor VIII or IX between 2-3 times a week;
that they did not infuse the factor immediately before the evaluation; individuals unable to realize and understand the proposed evaluations"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7mthsd	Influence of Smartphone use and Masticatory Behavior on food intake	Data analysis completed	Observational	2018-07-18	<NULL>	<NULL>	2024	Influence of Smartphone use, Masticatory Behavior on Stress status in students from a University at the souhtern region of Minas Gerais state	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Lavras - UFLA	Fundação de Amparo a Pesquisa do Estado de Minas Gerais - FAPEMIG	https://ensaiosclinicos.gov.br/rg/RBR-7mthsd	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 30 years; who thought they had a habit of using their cell phone while they were feeding	Individuals who reported food restriction of any kind (e.g. diet or specific feeding behavior for athletes)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-39czsv	Comparison between Therapeutic Ultrasound and Anesthesia Injection in women with Tummy Pain caused by a pain point for more than 6 months	Recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2025	Therapeutic Ultrasound and Local Anesthetic Injection in the treatment of women with Chronic Pelvic Pain secondary to Myofascial Abdominal Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-15	Faculdade de Medicina de Ribeirão Preto - FMRP-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - HCFMRP	https://ensaiosclinicos.gov.br/rg/RBR-39czsv	<NULL>	Women older than eighteen years and not menopausal with clinical diagnosis of abdominal myofascial syndrome with presence of only one active trigger point and pain above four point four (moderate pain) in the visual analogue scale (VAS) and without previous treatments.	Pregnant women with hip prosthesis, neoplasias in the abdomino-pelvic region, with severe osteoporosis, copper IUDs, abdominal varicose veins, cognitive deficits that make the questionnaires difficult to comprehend, women with anticoagulation or hemorrhagic disorders, local or systemic infections, allergy to anesthetics, acute muscle trauma, extreme fear of needles, history of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes. Also included in the exclusion criteria are those who use chronic painkillers, anti inflammatories, and tricyclic antidepressants who have used aspirin within three days prior to injection, all patients with suspected interstitial cystitis, bowel syndrome irritable or other disease that justifies or contributes to CPP, will also be part of the criteria for exclusion of endometrioma or hernia evidenced by ultrasound of the abdominal wall, abdominal wall infections and women who are missing after the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7xk5nr	Adherence to Drug Treatment in Patients with Chronic Pain: A Clinical Trial on the Use of Tablet Organizing Box	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2026	Drug Adherence of Patients with Chronic Pain: a Clinical Trial on the Use of Pill Box	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Departamento de Anestesiologia	"Universidade Estadual Paulista ""Julio de Mesquita Filho"" Faculdade de Medicina de Botucatu"	https://ensaiosclinicos.gov.br/rg/RBR-7xk5nr	<NULL>	Patients 18 years of age or older; with diagnosis of chronic pain; by the HCFMB-Unesp Pain Outpatient Clinic for a period of less than 1 year in an uninterrupted manner; be in use of at least two types of analgesic medication like opioids, anticonvulsants, common analgesics and antidepressants, in a maximum of four times a day; residing in the city of Botucatu and region; and be responsible for the administration and organization of analgesic medications	Patients with low cognitive capacity and illiterate; patients with cancer pain or fibromyalgia; history of non-adherence to other treatments; during the study, of dose adjustments and prescription of other medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-6rcgpr	Influence of a biomodifying compound on the dentin of deciduous teeth after removal of caries with laser	Recruitment completed	Intervention	2018-07-18	<NULL>	<NULL>	2027	Influence of the dentin rewetting with chitosan after selective removal of carious lesion by Er: YAG. Longitudinal clinical analysis, photographic and evaluation, marginal adaptation of the replica of the restoration and microbiological analysis.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-10	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-6rcgpr	<NULL>	"Presence of active carious lesions into
the dentin located on the occlusal surfaces (class I) in primary molars; with vital pulps;
and no sealants, amalgam, glass ionomer cement, or composite resin restorations;patients with good general health and with no complicating medical history."	Inactive caries lesion; Interproximal active caries lesion (class II, III and IV) or cervical (class V); Extensive and deep active carious lesion; Absence of pulp vitality; Presence of sealants, amalgam, glass ionomer cement or composite resin restoration; Patient with systemic problem or medical history of systemic complications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5ncdxh	Effect of patient positioning on Nephrolithotripsy results in the treatment of Complex Renal Calculations	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2028	Impact of Patient Position on the outcomes of Percutaneous Nephrolithothomy for Complex Kdney Stones	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-5ncdxh	<NULL>	Complex Kidney Stones; Classification Guys 3 or 4; Indication of percutaneous surgery	Contraindication for percutaneous nephrolithotripsy; Ipsilateral or contralateral ureteral calculus; Bladder calculus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7hfwzj	Dressings, nutritional supplementation and teaching of the patient and caregiver for the healing of bedsores	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2029	Effect of combined technology in the treatment of pressure injuries: contribution for clinic care management	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Goiás	Centro Estadual de Reabilitação e Readaptação Dr Henrique Santillo	https://ensaiosclinicos.gov.br/rg/RBR-7hfwzj	<NULL>	"Patients 18 years of age or over; pressure injury in stages 2, 3 or 4 up until 24 cm2; body mass index equal or greater than 18,5 kg/m2 and lower than 30 kg/m2 and therapeutic plan of hospitalization in the institution for at least 30 days; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity

Caregivers 18 years of age or older; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity"	"Patients with a previous history of allergy to any plant from the Asteraceae or Pedaliaceae family; renal or liver diseases; osteomyelitis; cellulitis; systemic use of corticoids; immunosuppressants, radiation, chemotherapy less than four weeks before entering this study and myiasis

Caregivers with visual deficit that blocks visualization of the educational material for the care; hearing deficiency moderate to severe that blocks orientation comprehension"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-8dzth2	Clinical Efficacy and Gynecological Acceptance of the Product	Recruitment completed	Intervention	2018-07-19	<NULL>	<NULL>	2030	Evaluation of Clinical Efficacy and Gynecological Acceptability of Product for Health	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-10	Medcin Instituto da Pele Ltda	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8dzth2	<NULL>	66 female participants; aged 40 to 80 years; healthy with complaints of urinary incontinence and vaginal atrophy who wish to participate in the study.	Gestation or risk of gestation; use of anti-inflammatory drugs; immunosuppressants in the last 30 days or during the study; active cutaneous conditions; history of product irritation at the site of evaluation; endocrine pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-69hdz2	Speech to Patients Who Will Undergo Cardiac Surgery Reduces Stress and Anxiety	Recruitment completed	Intervention	2018-07-19	<NULL>	<NULL>	2031	Educational intervention reduces patient&apos;s stress and anxiety Cardiac Surgical: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-26	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-69hdz2	<NULL>	Inclusion criteria were elective patient for cardiac surgery; first performed the cardiac surgical procedure; be over 18 years of age; oriented in the time and space and to be in medical follow-up in the cardiac surgery service of the Hospital researched.	The exclusion criteria were patients who underwent other emergency cardiac surgeries; who had neurological sequelae or any psychiatric disorder being unable to respond to the questionnaires applied in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-47qws8	Assessment of caries risk and oral health status of infants and children aged 0 to 3 years	Recruitment completed	Observational	2018-07-19	<NULL>	<NULL>	2032	Assessment of caries risk and oral health status of infants and children aged 0 to 3 years	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-47qws8	<NULL>	Volunteers children; both genders, age between 0 and 4 years; weight within the variation limit of 15% of the normal weight considered for children	Voluntary Children over 4 years; who does not want to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7sp8mf	Beetroot leaves (Beta vulgaris L.) supplememntation improve biochemical and anthropometric parameters of Obese and Dislipidemic patients	Recruitment completed	Intervention	2018-07-19	<NULL>	<NULL>	2033	Beetroot leaves and stalks (Beta vulgaris L.): characterization and effects of antioxidant capacity in Obese and Dyslipidemic individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7sp8mf	<NULL>	Men or women aged 20 to 59 years; Body Mass Index (BMI) for obesity grade I or II (between 30 and 39.9kg/m2); presenting changes in serum lipid levels with total cholesterol &gt;200mg/dl and LDL-cholesterol above 130mg/dl, as prescribed by the Brazilian Society of Cardiology	Patients with renal or hepatic impairment, volunteers who underwent bariatric surgery and who suffered stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7x828q	Treatment of muscle knots in the neck of subjects with mandibular disfunction	Recruitment completed	Intervention	2018-07-20	<NULL>	<NULL>	2034	Treatment of muscle knots in the neck of subjects with TMD: a pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	universidade federal de sao carlos	universidade federal de sao carlos	https://ensaiosclinicos.gov.br/rg/RBR-7x828q	<NULL>	Moderate or severe TMD signs and symptoms according to Fonseca&apos;s Anamnestic Index; headache complaints; diagnosis of myogenic or mixed TMD according to the RDC / TMD (Research Diagnostic Criteria for Temporomandibular Disorder); pain in the TMJ for at least 3 months, with a minimum score of 3 cm for the Visual Analogue Scale (EVA); presence of myofacial triggers in sternocleidomastoid, suboccipital and / or upper trapezius.	Diagnosis of fibromyalgia; history of trauma or surgery in the cervical spine or temporomandibular joint; dental or pharmacological treatment with analgesics or muscle relaxants in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-655c3z	Evaluation of composite resin restorations and glass ionomer cement by applying differently the adhesive system	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2035	"Study of the clinical performance of different accession strategies of noncarious
cervical lesions restorations"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Estadual Paulista - Faculdade de Odontologia de Araçatuba	Centro Universitário São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-655c3z	<NULL>	Age between 18 and 90 years old; regardless of genre; good health; no clinical history of allergies to dental products and remedies; presence of at least 4 non-carious cervical lesions; proper oral hygiene.	Chronic systemic disease; periodontal disease and without treatment; use of orthodontic appliances; severe bruxism, with more than 50% of wear.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3bvjjm	Effectiveness of an educational booklet for the prevention of mother-to-child transmission of the Human Immunodeficiency Virus	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2036	Educational booklet for prevention of vertical Human HIV: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Ceará	Departamento de Enfermagem - UFC	https://ensaiosclinicos.gov.br/rg/RBR-3bvjjm	<NULL>	Have proven HIV status, to be performing prenatal care in the chosen institutions during the study data collection period	Present a state of physical or mental health compromised in order to make data collection unfeasible, pregnant women living in the streets and incarcerated, so that the mother&apos;s accompaniment is unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9f3wwp	Can turmeric powder treat asthma in children?	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2037	Effects of Curcuma longa L. administration to children with persistent asthma	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9f3wwp	<NULL>	Children between 7 and 18 years; with a diagnostic of persistent asthma, mild, moderate or severe, controlled or not.	Allergy to C. longa; parental request; failure to adhere to the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-6wzmwx	Effects of Ice and Electrical Current on patients with partial loss of movement and muscle stiffness	Recruiting	Intervention	2018-07-20	<NULL>	<NULL>	2038	Effects of Chryotherapy and Neuromuscular Electrical Stimulation in Spastic Hemiparetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-12	SOBEU - Associação Barramansense de Ensino	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-6wzmwx	<NULL>	Patients in the chronic phase of stroke (at least 3 months after injury); have a maximum grade 3 and minimal degree +1 spasticity according to the Modified Ashworth scale; medical indication for physical therapy; adequate understanding and communications competencies; agree to be part of the study in accordance with the authorization of free and informed consent	Patients younger than 45 and older than 90 years who present with Raynaud&apos;s disease; thromboangiitis obliterans; cryoglobulinemia; cold urticaria; uncontrolled hypertension; sensory deficiency; cold aversion; spasticity grade 4 according to the modified Ashworth scale; aphasia or Wernick&apos;s dysphasia; trophic changes at the site of electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-4hm7mz	Effect of fortification with powder nutrients in prevention and treatment of nutrient deficiency	Recruiting	Intervention	2018-07-23	<NULL>	<NULL>	2039	Effectiveness of fortification with powder micronutrients in prevention and treatment of micronutrient deficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-09	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4hm7mz	<NULL>	Children aged six to 48 months; anemic and non-anemic.	Children in treatment of anemia; malaria; HIV, hemoglobinopathies or hemochromatosis; low weight at birth; preterm birth (less than 37 weeks); twin; allergies reported to any components of the fortification sachet and/or to ferrous sulfate/folic acid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7tqc7k	Clinical pharmacology of tamoxifen in breast cancer patients	Data analysis completed	Observational	2018-07-23	<NULL>	<NULL>	2040	Tamoxifen population pharmacokinetics in breast cancer patients: metabolism study, genetic polymorphism, hormonal status and age	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7tqc7k	<NULL>	Breast cancer patients on adjuvant tamoxifen treatment for more than 80 days who have not been treated with other co-medications that may interfere with the study have been investigated. For the study, two groups of patients will be delimited according to age and hormonal status, being a premenopausal group (age less than 50 years) and another postmenopause (age higher than 60 years).	Patients with comorbidities that interfere with the metabolism of tamoxifen and the probe drugs were excluded; patients who have previously chemotherapy and / or target therapy; patients who have contraindications to the use of the probe drugs metoprolol, midazolam and fexofenadine; and psychiatric patients unable to understand ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-3kwymc	Nutritional profile and dietary patterns of patients with kidney stones	Recruitment completed	Intervention	2018-07-23	<NULL>	<NULL>	2041	Nutritional profile and dietary patterns of stone formers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de São Paulo - UNIFESP	Fundação Oswaldo Ramos	https://ensaiosclinicos.gov.br/rg/RBR-3kwymc	<NULL>	Patients diagnosed with kidney stones; confirmed by imaging; age between 18-60 years	Pregnant women; individuals with current urinary tract infection; cystinuria or other monogenic diseases; inflammatory bowel disease; primary hyperparathyroidism, severe liver disease; and current use of supplements or vitamins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9792k8	Evaluation of ultrasonic whole-mouth instrumentation in the treatment of Chronic Periodontitis in diabetic patients	Data analysis completed	Intervention	2018-07-23	<NULL>	<NULL>	2042	Evaluation of periodontal debridement in the treatment of Chronic Periodontitis in diabetic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-19	Escola Bahiana de Medicina e Saúde Pública	Ambulatório Docente Assistencial da Bahiana	https://ensaiosclinicos.gov.br/rg/RBR-9792k8	<NULL>	Presented severe chronic periodontitis verified by the presence of periodontal pockets, loss of insertion and radiographic bone loss; presence of at least 8 teeth with probing depth greater than or equal to 5 mm and bleeding at probing, of these at least 2 teeth should have a depth of probing greater than or equal to 6 mm and 2 more with depth of probing greater than or equal to 7 mm; decompensated diabetics, glycated hemoglobin value greater than or equal to 7%; minimum of 15 teeth, excluding third molars	Periapical or pulp alterations on qualifying teeth, consumption of drugs known to affect periodontal status (antibiotic, anti-inflammatory, anticonvulsant, immunosuppressant, or calcium channel blocker) within the past 3 months, periodontal treatment, including subgingival scaling and root planning in the preceding 6 months,  systemic and immunological disorders other than diabetes that require prophylactic antibiotic coverage or that could influence response to treatment, smoking, pregnancy and cardiac pace-makers users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5g4n3p	Evaluation of zika test for yellow fever vaccineted.	Not yet recruiting	Observational	2018-07-23	<NULL>	<NULL>	2043	Performance Evaluation  of the Rapid Test for Serological Diagnosis of Zika (TR DPP IgM / IgG Zika - Bio-Manguinhos) in a Cohort of Yellow Fever Vaccines	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-01-29	Instituto de Tecnologia em Imunobiológicos de BioManguinhos/Fundação Oswaldo Cruz (Fiocruz)	Ministério da ciência, tecnologia, inovações e comunicações - CNpq	https://ensaiosclinicos.gov.br/rg/RBR-5g4n3p	<NULL>	Adult participant or the person legally responsible be able to understanding and signing the TCLE. If the participant or the person legally responsible in charge is not able to sign, the TCLE can be signed by an impartial witness who has been following the whole procedure; Acceptance of participation in the study, after reading and understanding of the Informed Consent Form (TCLE) and signature of the same; Participants of both genders aged from 9 months to 4 years 11 months and 29 days, since they are not received or received by Viral Triple Vaccine or Viral Tetra within an interval of 30 days or less; Healthy adults of both genders aged 18-50 years since they are not received or received by MMR or MMR within 30 days or less; Permanent residence in the municipality where a Basic Health Unit is located, where a vaccination and collection of biological material (blood) is carried out for the study, at the time of inclusion in the study; Never have resided or stayed temporarily in an area with a yellow fever vaccination recommendation; Do not travel to areas with vaccination recommendation against yellow fever; Availability for follow-up activities throughout the study period; Agree on provide the name, address, telephone and other personal information, if applicable, if necessary (for example, in the case of a missed visit scheduled for follow-up); Availability to follow the study protocol; Acceptance for serological testing for HIV; In adult women of childbearing age, a pregnancy test (TIG); Have a good health with no significant medical history (as described in the exclusion criteria); Physical examination of significant clinical clinical trials.	Previous vaccination for yellow fever; Presumed or confirmed pregnancy, at any stage; Women who are breastfeeding; People in current or recent use of immunosuppressive drugs; People with a personal history of anaphylactic reaction to food, medicine, or vaccines; People with a personal history of egg, erythromycin, kanamycin, or gelatin allergies; People with autoimmune diseases; HIV-seropositive individuals; People with a history of thymus diseases, such as thymoma, myasthenia gravis and thymectomy due to thymoma; Persons who have received immunoglobulin, blood transfusions or derivatives in the last 60 days; Persons who have received live virus or cholera vaccines within the past 30 days or who plan to receive them within 30 days after vaccination for yellow fever; People with acute febrile illness, with compromised general health; Persons who have presented rash within the past 30 days; Persons immunocompromised by disease (eg neoplasms, AIDS, HIV infection with impaired immunity etc.) or by drugs (immunosuppressive drugs, radiation therapy etc.).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5j3h3c	Comparison between 2 and 5 minutes of  stretching in the calcaneus tendon	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2044	Comparison between 2 and 5 minutes of passive static stretching in the mechanical properties of the calcaneus tendon in young adults: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5j3h3c	<NULL>	Be between 18 and 40 years old;To be physically active, but not engaged in strength training and flexibility according to the classification of the International Physical Activity Questionnaire (IPAQ)	Do not compare with evaluations (pre or post);Withdraw your consent;Have two consecutive fouls or three interspersed without a stretching program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7354r6	Effects of Aerobic Training During Heart Rate Hemodialysis in Patients With Chronic Renal Disease	Data analysis completed	Intervention	2018-07-24	<NULL>	<NULL>	2045	Analysis of Heart Rate Variability in Exercise Supervised in Cicloergometry in Patients with Chronic Renal Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-12	Faculdade de Medicina do abc de Santo André.	Faculdade de Medicina do abc de Santo André.	https://ensaiosclinicos.gov.br/rg/RBR-7354r6	<NULL>	Outpatients of both sexes; literate; aged 18 years or over; who were undergoing renal treatment for at least six months	Volunteers who have unstable angina; uncontrolled systolic or diastolic arterial hypertension; use of antiarrhythmics; severe pneumopathies; acute systemic infection; severe renal osteodystrophy; disabling neurological and musculoskeletal disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7cp49x	Effect of a Strength and Resistance Training protocol on Heart Variability in patients with kidney disease who are not on hemodialysis	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2046	Effectiveness of a Strengthening and Aerobic Training protocol on Heart Rate Variability in Predialytic patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7cp49x	<NULL>	Stages 4 and 5 non-dialysis chronic kidney disease patients; between 18 and 60 years old; from both sexes; using no medication that alters the autonomic nervous system	Patients in the following conditions will be excluded from this study those who participated in an intervention program less than three months ago; or presenting unstable arterial hypertension with diagnosed by a physician; amyloidosis; congestive heart failure; acute infarction; myocardial infarction (up to three months); unstable angina; osteoarticular abnormalities that make it impossible for them to execute the exercise protocols; peacemaker users and those who underwent heart transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-38nfg2	Effect of supplementation of vitamin and the serum and milk of breastfeeding women	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2047	Effect of supplementation with 800 IU of vitamin E on serum alpha-tocopherol and milk of lactating women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-18	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-38nfg2	<NULL>	Women 30 to 60 days postpartum who are in the waiting room of the ambulatory care and breastfeeding their child; residents of Natal, state of Rio Grande do Norte; without diagnosis of diseases such as hypertension, diabetes, neoplasias, cardiopathies, diseases of the gastrointestinal and hepatic tract, syphilis, HIV positive; non-smokers and who had deliveries with a single concept and without malformation.	Women who do not have milk; illicit drug users who use vitamin E vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-65nfhn	Evaluation of program in oral health education in children and adolescents with chronic kidney disease	Not yet recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2048	Humanoid robots - Evaluation of artificial intelligence in oral health education in children and adolescents with chronic kidney disease: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de odontologia da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65nfhn	<NULL>	Children and adolescents aged 6 -18 years; cooperators in relation to the initial clinical examination and understanding of the questions and orientations presented; with possibility of follow-up for 1 month.	Children who presented an acute systemic picture in the last 30 days; children who are feeding via catheter, with cognitive and / or motor deficiency and with orthodontic appliance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-3r88x9	Use of Goserelin for medical treatment of Uterine fibroids	Recruitment completed	Intervention	2018-07-24	<NULL>	<NULL>	2049	Use of Goserelin for medical treatment of Uterine fibroids	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2015-10-26	Financiamento próprio	Empresa Brasileira de Serviços Hospitalares	https://ensaiosclinicos.gov.br/rg/RBR-3r88x9	<NULL>	Woman; older than 18 year; diagnosis of uterine fibroids	Menopause; cancer; drug hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7p87yr	Effect of different Toothpastes on tooth enamel	Recruitment completed	Intervention	2018-07-24	<NULL>	<NULL>	2050	Effect of different Toothpaste on dental enamel: a double blind in situ study	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	Faculdade de Odontologia de Ribeirão Preto	LaABio - Laboratório de Análise de Biomateriais	https://ensaiosclinicos.gov.br/rg/RBR-7p87yr	<NULL>	Individuals with good general health; aged between 20 and 35 years; without pathologies in the soft and hard oral tissues; not using any type of dental prosthesis or orthodontic appliance; not under medical or dental treatment; who are not participating in no other study	Individuals who use removable prostheses; individuals with altered salivary flow; individuals with decayed teeth or with periodontal disease;  individuals with digestive disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-535smn	Effects of Strength and Aerobic Training on Physical Performance in Patients with Chronic Obstructive Pulmonary Disease who Use Oxygen at Home	Recruitment completed	Intervention	2018-07-24	<NULL>	<NULL>	2051	Effectiveness of Resistance and Aerobic Training on functional performance in patients with COPD users of home oxygen therapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Parana	https://ensaiosclinicos.gov.br/rg/RBR-535smn	<NULL>	We included patients with clinical and functional diagnosis of COPD according to the criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (RABE et al, 2007), both sexes over 50 years of age, clinically stable (outside the period of exacerbation regardless of disease staging, and who used home-based oxygen therapy regardless of the time (hours / day) of use and who were not included in any rehabilitation program or physical training in the last year.	Patients with other lung diseases (asthma, pulmonary fibrosis, pneumonia) were excluded; presence of other non-pulmonary diseases considered to be incapacitating, severe or difficult to control (eg heart disease or the sequelae of acute or chronic neurological diseases), which could disrupt the application of tests; those with cognitive status compromised according to the Mini Mental State Examination (MMSE) (&lt;13 for illiterates; &lt;18 for individuals with 1 to 7 years of schooling and &lt;26 for 8 years or more of schooling).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7vwsj9	Effects of myofascial realese time with baton over the neuromuscular performance of elbow flexors	Recruitment completed	Intervention	2018-07-20	<NULL>	<NULL>	2052	Effects of different magnitudes of strength applied in massage on performance and neuromuscular activation in elbow flexors	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade de Brasilia -Faculdade de Educação Fisica	Universidade de Brasilia -Faculdade de Educação Fisica	https://ensaiosclinicos.gov.br/rg/RBR-7vwsj9	<NULL>	Healthy young people; male; age between 18 and 30 years;Physically active according to the IPAQ;	With osteomioarticular commitment of upper limbs; users of medications that may affect muscular function;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-83kysp	Acute Effect of Full-Body Vibration in Women with Fibromyalgia	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2053	Acute Effect of Full-Body Vibration Stimulation in Women with Fibromyalgia	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação De Amparo a Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-83kysp	<NULL>	Women aged 35 to 70 years; with confirmed diagnosis of fibromyalgia between 1 and 3 years; presence of sensitivity in at least 11 of the 18 specific pain points according to the American College of Rheumatology criteria.	Volunteers who present; any concomitant illness that may be exacerbated by physical activity; pregnancy; orthopedic limitations; inflammatory diseases; degenerative diseases; articular; respiratory or cardiovascular diseases; who are being followed up with a psychiatrist; who perform physical activity for the same 2 times a week; (acute hernia, thrombosis, diabetes, epilepsy, metabolic or neuromuscular diseases, orthopedic injuries and prosthetics); use immunosuppressive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-4vjrcx	The effect of Kundalini Yoga intervention in people with the diagnosis of Obsessive-Compulsive Disorder	Recruitment completed	Intervention	2018-07-25	<NULL>	<NULL>	2054	Evaluation of the acute effect of Kundalini Yoga on Obsessive Compulsive Disorder	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-24	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4vjrcx	<NULL>	Present OCD according to DSM-5; minimum age of 18 and maximum of 65 years; if taking medication, the doses should be stable for at least 3 months	Uncrontrolled systemic arterial hypertension; mental retardation; major depression with psychotic symptoms; schizophrenia; bipolar affective disorder; recent cranio-encephalic trauma with intracranial hypertension; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5hq3xh	The practice of Pilates exercises associated with Buteyko exercises in children and adolescents with asthma	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2055	Effects of the application of the Pilates method and combination with the Buteyko method in children and adolescentes asthmatics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Universidade Federal de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5hq3xh	<NULL>	"Patients of both sexes;
Age from 7 to 15 years;
Pacients with persistent asthma
moderate and severe;
In outpatient follow-up
regular."	"Volunteers who had episodes of recent respiratory infections (less than 30 days);
Cardiovascular, orthopedic and rheumatologic diseases;
Non-performance of lung function tests;
Absences from sessions (25% or more)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-63hk5w	Biotin 2.5mg oral and Minoxidil 5% increase the speed of growth of the nails of the hands in healthy adults.	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2056	Evaluation of nail growth: comparison between Biotin and topical Minoxidil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-22	UNESP - Universidade Estadual Paulista	UNESP - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-63hk5w	<NULL>	Healthy men and women; 18 to 65 years	Pregnant; infants; active smokers; active alcoholics;cutaneous or systemic pathology influencing nail growth; drugs established in the literature that alter nail growth; allergy to minoxidil or biotin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9b4v63	Evaluation of the characteristics of patients with lung disease who use oxygen for 12h / day in the period of one year	Data analysis completed	Observational	2018-07-25	<NULL>	<NULL>	2057	Evaluation of the evolutionary characteristics of patients with exercise-induced hypoxemia who use prolonged home oxygen therapy for 12 hours per day in a one-year period	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-11-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; Unesp - Faculdade de Medicina de Botucatu	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9b4v63	<NULL>	Effort Transient Hypoxemia; Do not present arterial hypoxemia at rest	Severe arterial hypoxemia; Cancer; Active smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-3cr9jh	Effect  of cinnamon supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	Data analysis completed	Intervention	2018-07-25	<NULL>	<NULL>	2058	Effect  of cinnamon (Cinnamomum zeilannicum) supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3cr9jh	<NULL>	Women with 12 months of amenorrhea; overweight or obese; age between 45 and 59 years.	use of anticoagulants, anti-lipidemic, antihypertensive and oral hypoglycemic agents and insulin; patients with hepatic dysfunction; hormone replacement; who has had chemotherapy; who has allergy or hypersensitivity to cinnamon.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5pg989	Assessment and treatment of shoulder Pain	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2059	Assessment and intervention of shoulder Dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5pg989	<NULL>	"Category 1 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form.

Category 2 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; athletes practicing regular physical activity that perform aerial launch movements; Acceptance in the Informed Consent Form.

Volunteers will be included for category 3, adults over 18 years of age, female; volunteers with complaints of wrist and hand pain with irradiation in the upper limb diagnosed as compressive syndrome will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form."	Participants who do not attend the reevaluations, do not carry out the proposed home protocol will be excluded; failure to complete the questionnaires; unable to perform the proposed exercises on the first day of the assessment; discomfort during the performance of exercises such as dizziness and nausea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8bn3y2	Effect of Blocking a nerve in the neck and arm on inflammation in shoulder surgery. Comparative study	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2060	Effect of Interscalene Block on the inflammatory response in Shoulder surgery. Comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Instituto Nacional de Rehabilitación	Instituto Nacional de Rehabilitación	https://ensaiosclinicos.gov.br/rg/RBR-8bn3y2	<NULL>	"Patients scheduled for arthroscopic surgery of the shoulder; Patients of both genders; Patients from 35 to 70 years age
Patients with American Society Anesthesiologists (ASA) physical status classification I or II; Patients who agree to participate in the study; Patients with leukocyte count within normal (count among 4 x 103/mm3 and 11 x 103/mm3)"	Patients with obesity (body mass index higher 30 Kg/m2); Patients with malnutrition; diabetes mellitus; metabolic syndrome; pre-existing coagulopathy; acute or chronic focus of infection; congenital or acquired immunological disease; collagen disease; local or systemic inflammatory disease; endocrine disease; oncological disease; psychiatric illness; organ failure; chronic pain in another bodily region; use of steroids or immunomodulators; chronic use of non-steroidal anti-inflammatory drugs; chronic use of alpha2-adrenergic agonists; previous surgery of the same shoulder and airway difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-62h256	"Evaluation of the spontaneous breathing test in 
predicting the withdrawal from mechanical ventilation after cardiac surgery 
in children"	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2061	"Evaluation of the efficacy of the spontaneous breathing test in 
predicting the success of extubation in the postoperative period of cardiac surgery 
in children: A randomized controlled trial."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-31	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62h256	<NULL>	Children; aged 0-18 years; with congenital heart disease; admitted to the pediatric intensive care unit after cardiac surgery; receiving mechanical ventilation for more than 12 hours.	preoperative mechanical ventilation; uncontrolled pulmonary hypertension; refusal to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9wqbx9	Comparative analysis of two solutions for miocardial protection in the correction of congenital cardiopathies.	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2062	Comparative analysis of myocardial protection with HTK solution and hypothermic hyperkalemic blood solution in the correction of acyanogenic congenital cardiopathies – a randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9wqbx9	<NULL>	Children with acyanotic congenital cardiopathies submitted to corrective surgery with extracorporeal circulation and aortic clamping and volunteers to participate in the study.	Children operated for correction of atrial septal defect exclusively, reoperations, palliative surgeries, emergency surgeries, negative in participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5qwkqd	Effects of bed bath on physiological changes: randomized clinical trial	Recruiting	Intervention	2018-07-26	<NULL>	<NULL>	2063	Effects of bag bath and bed bath on oxi-hemodynamics changes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-13	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5qwkqd	<NULL>	Admitted to the Intensive Care Unit studied; have an age of 18 years or more; be submitted to  procedure bed bath for purposes of promoting comfort and / or body hygiene.	patients with medical diagnosis of neurological alterations that compromise the regulation of body temperature and burns of great extent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6xmd7x	Effect of Fluoxetine on skin coloration in patients with vitiligo: a clinical study	Recruiting	Intervention	2018-07-27	<NULL>	<NULL>	2064	Effect of Fluoxetine in pigmentation of the skin in Vitiligo carriers: clinical study	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6xmd7x	<NULL>	Have a diagnosis of segmental or non-segmental vitiligo by dermatologist;be at least 18 years old;have 3 to 50% of the area of the affected body surface	Be carrying out any method of treatment for at least three months, those with any autoimmune disease, patients with more than 50% of the body surface affected, pregnant or lactating women, patients with skin cancer, patients with psychological disorders, patients with photosensitive conditions, vitiligo limited only to the genitals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2qybt6	Effectiveness and Genetic Damage associated with Tooth Whitening	Recruitment completed	Intervention	2018-07-27	<NULL>	<NULL>	2065	Effectiveness of Bleaching with 37%  Carbamide Peroxide With and Without Sonic Activation and Genotoxic Effect: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Universidade Federal do Amazonas - UFAM	Universidade Federal do Amazonas - UFAM	https://ensaiosclinicos.gov.br/rg/RBR-2qybt6	<NULL>	Patient from 18 years of age; upper teeth free of caries; anterior superior teeth free of restorations on the vestibular face; central or canine incisors showing coloration C2 or darker	Pregnant or lactating; Smokers; Users of fixed orthodontic appliance; Individuals with severe intrinsic stains on the teeth; Users of drugs with anti-inflammatory and antioxidant action; Participants with a previous history of dental sensitivity or any associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-2w9bhc	Nutritional intervention in overweight pregnant women attending primary healthcare units	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2066	Nutritional intervention study in overweight pregnant women attending primary healthcare units: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Centro de Saúde Escola - Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2w9bhc	<NULL>	Age over 18 years old; gestational age at the time of screening up to the 15th weeks and 6 days; and BMI at the time of screening between 25 and 29.9 kg per square meter	Twin pregnancy; previous diabetes; in use of weight loss medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8p9v7v	Educational Intervention in Breastfeeding	Data analysis completed	Intervention	2018-07-30	<NULL>	<NULL>	2067	Technology in Breastfeeding: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-16	Universidade Estadual de Campinas - UNICAMP	Hospital Samaritano de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8p9v7v	<NULL>	Being in the mid-term in the joint housing; Accept participating in the study for up to 60 days after the birth of the baby; Have a landline or cell phone; Be practicing Exclusive Breastfeeding during the stay in the joint accommodation.	Mothers of high and medium risk babies or premature infants who were not able to breastfeed;Puerperas with communication difficulties, whether due to hearing impairment or not speaking our language (Brazilian Portuguese).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5nx7fk	Regression evaluation of swelling in the face after orthognathic surgery with and without the use of functional elastic bandage in patients with cleft lip and palate	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2068	Regression evaluation of facial edema after orthognathic surgery with and without the use of Kinesio Taping in patients with cleft lip and palate: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-17	Hospital de Reabilitação de Anomalias Craniofaciais HRAC/USP	Hospital de Reabilitação de Anomalias Craniofaciais HRAC/USP	https://ensaiosclinicos.gov.br/rg/RBR-5nx7fk	<NULL>	"Agree to the free and informed consent term;
Agree to remain in the hospital the time necessary for the data collection;
Presence of cleft lip and palate repaired;
Both sexes aged between 18 and 40 years;
Indication for bimaxilar orthognathic surgery"	"Present hypersensitivity to Kinesio Taping tape;
To present facial lymphedema grade III and IV;
To present peripheral facial neuralgias;
To present moderate or severe hematoma in the postoperative period;
Have severe intra- or postoperative bleeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-67cjv5	Clinical study in the treatment of menstrual cramps	Recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2069	Randomized clinical trial in the treatment of primary dysmenorrhoea syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-67cjv5	<NULL>	Accept signing the free and informed consent form; age between eighteen and thirty-five years; pelvic pain caused by primary dysmenorrhea; first to the third day of the menstrual cycle; between one and ten on the analogue visual pain scale	Age less than eighteen and over thirty-five years; patients taking analgesics and other therapies for pelvic pain; gynecological pathologies; undiagnosed abdominal pain; patients with cardiac pacing; cardiac complications; degree 0 on the visual analogue pain scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3b69nt	The use of Pain Medicines after Primary Teeth Extractions: from Prescription to reality	Recruiting	Observational	2018-07-30	<NULL>	<NULL>	2070	The use of Analgesics after Primary Teeth Extractions: from Prescription to reality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Universidade Federal de Santa Maria/Pró Reitoria de Pós Graduação e Pesquisa	Universidade Federal de Santa Maria/Pró Reitoria de Pós Graduação e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-3b69nt	<NULL>	parents or guardians of children who have undergone primary tooth extraction	Parents or guardians of children who have undergone exodontia of embedded, ankylosed, fused or removed teeth without the use of local injectable anesthesia will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-7m4v7b	Evaluation of the use of Ranitidine in diabetic patients with severe infection (sepsis)	Recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2071	A phase II randomized, double-blind, placebo controlled study of the safety and efficacy of ranitidine in diabetic patients with severe sepsis and septic shock.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-04-02	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m4v7b	<NULL>	Patient with age greater than 18 years; Admitted to the Emergency Unit of Clinical Hospital of Ribeirão Preto medical school of University of São Paulo (UE-HCFMRP/USP);  diagnosis of diabetes mellitus or serum glucose &gt; 200 mg / dL at the admission; diagnosis of severe  sepsis or septic shock; ability of the patient or his or her legal representative to decide whether or not to participate in the survey before completing 48 hours of admission.	Septic Patients who do not have the criteria for severe sepsis or septic shock; continuous use of  ranitidine or other H2 antagonist; hypersensitivity to ranitidine or other H2 blockers; pregnant women; participation in another study; diagnosis of HIV; realization of chemotherapy in the last 30 days; palliative care; lymphoproliferative disease; refusal to signing the consent form (CF) or not to participate in the study; need of procedure or examination with contrast which requires the use of ranitidine as premedication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3st5sn	Test of a strategy for childhood obesity based on the Food Guide for the Brazilian Population	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2072	Effectiveness of a strategy for the treatment of childhood obesity based on the Food Guide for the Brazilian Population: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-3st5sn	<NULL>	Be between 7 and 10 years old. Be obese.	Possessing pre-existing genetic disorders associated with obesity such as congenital leptin deficiency, Down syndrome, Prader-Willi syndrome) or endocrine disorder (hypothyroidism, Cushing&apos;s syndrome). Children and adolescents with some deficiency that prevents the accomplishment of anthropometric measurements. Patients undergoing nutritional monitoring and using medications for weight loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9gchqr	Effects of a training in ensuring long term improvement of knowledge, attitudes and practices of community health workers in maternal and infant health	Data analysis completed	Intervention	2018-07-31	<NULL>	<NULL>	2073	Innovations in maternal and child care in Pernambuco - Quality evaluation cycle of maternal fetal care in maternity hospitals in Pernambuco	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq),	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9gchqr	<NULL>	Community Health Workers who work in Family Health Units that are co-managed by the municipal health authority of Recife and the Institute of Integral Medicine Professor Fernando Figueira (IMIP).	Community Health Workers who were on vacation or on any type of leave during the data collection periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-74zbms	Electrostimulation physiotherapy influence on the sexual function of women with precocious menopause: controlled randomized clinical study	Not yet recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2074	Interferential Current influence on the sexual function of women with Premature Ovarian Failure: controlled randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-74zbms	<NULL>	Women with Premature ovarian Insufficiency for one year or more;  in use of systemic hormone therapy three months or more; Age between 18 and 50 years, sexually active; Presenting sexual activity for at least six months with at least one intercourse in the last four weeks	"Women with complaints of sexual dysfunction exclusively related to the absence of desire; Use of copper IUDs, pacemakers, or some type of metal implant in the lumbar spine or hip region; Women with an acute infectious process in the vulvar region, genital ulcer or using medications that may cause mucositis; Women undergoing systemic or acute localizes allergic conditions;
Women who are known to have a chronic degenerative disease, chronic immunosuppression, pelvic or spine deformity, neoplastic diseases; Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3m7fdv	Effect of individual and group exercise on pain and fatigue caused by cancer	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2075	Effect of individual or collective kinesiotherapy on pain and oncological fatigue	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-20	Universidade Federal de Sergipe	Associação de Amigos da Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-3m7fdv	<NULL>	Anatomopathological diagnosis of breast cancer; radical or total mastectomy surgery; have or have not had adjuvant chemotherapy; removed from the drain; have up to four months of performing the surgical procedure; surgical incision healed.	Malnutrition; metastasis; lymphedema; bilateral breast cancer; immediate breast reconstruction; had adjuvant radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-7qk2cs	Transcranial current stimulation in patients undergoing hemodialysis	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2076	Transcranial Direct Current Stimulation and its therapeutic potential in patients undergoing Hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-15	Universidade Federal do Rio Grande do Norte	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qk2cs	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression, anxiety, chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6fyh2c	The effect of health education on the patient with chronic pain	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2077	Effect of a health education program on individuals with chronic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-6fyh2c	<NULL>	Individuals enrolled in the health teams of the Pituaçu family health units and Pituaçu Park; daily or near-daily pain for at least six months; between the ages of 18 and 60; who were literate.	Pregnant women; people with difficulties to understand the questionnaires; associated diseases that can reduce the level of quality of life;functional illiteracy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3qzhvg	Use of Subconjunctival Epinephrine in Retinal Surgeries in order to ease fundus visualization throughout surgery	Data analysis completed	Intervention	2018-08-01	<NULL>	<NULL>	2078	Efficacy of 0.1% Epinephrine Subconjunctival Injection versus Placebo in Intraoperative Mydriasis Maintenance during Vitrectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte - HUOL/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-3qzhvg	<NULL>	Patients submitted to isolated vitrectomy; Age of 18 or higher.	Pseudophakic patients with the cataract surgery performed in less than 6 months; History of uveitis; pseudoexfoliation; trauma; use of any systemic or topical anti-inflammatory medications within 2 weeks to surgery; Intraoperative complications; Patients submitted to scleral buckling or any anterior chamber procedure during vitrectomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8sk5j9	Validation study of the AGE-Reader device (Trade Mark) in the Brazilian population with or without kidney diseases	Recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2079	Validation study of the AGE-Reader (Trade Mark) in a sample of the Brazilian population with and without chronic kidney disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Serviço de Nefrologia do Departamento de Clínica Médica da Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP),	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8sk5j9	<NULL>	"Control group: Will include 300 individuals with age greater than or equal to 18 years; with Fitzpatrick skin phototype I to IV; no history of Diabetes Mellitus and Chronic Renal Disease or smoking.

Chronic Kidney Disease Group (CKD): 300 patients with CKD according to the criteria of Kidney International Disease Improvement Global Outcome (KDIGO) and treated at the HC-FCM-UNICAMP Nephrology Service; 75 of them in stage 3B of CKD, 75 in stage 4 or 5 non-dialytic of CKD, 75 on hemodialysis, and 75 on peritoneal dialysis; with age greater than or equal to 18 years. Patients with DM or smokers will not be excluded."	"Control Group: Individuals aged younger than 18 years; with Fitzpatrick skin type VI to VI; with a history of Diabetes Mellitus and smoking; and individuals who do not agree with the terms set forth in the Free and Informed Consent Term will be excluded.

Chronic Kidney Disease Group: Individuals aged younger than 18 years; with a Fitzpatrick skin V to VI phototype; individuals who do not agree with the terms set forth in the Free and Informed Consent Term will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9qdnws	Clinical evaluation of drugs in people with dry mouth	Data analysis completed	Intervention	2018-08-01	<NULL>	<NULL>	2080	clinical evaluation of Pilocarpine release systems in individuals with hyposalivation	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-04-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qdnws	<NULL>	"Volunteers aged 18 or over.
With clinical diagnosis of hyposalivation salivary flow at rest less than or equal to 0.1 ml / min for at least two weeks before the research with no probability of resolution during the experimental period. There is no known allergy or sensitivity to pilocarpine.Ability to give informed consent in writing and meet all testing requirements."	No possibility of changing any drug with the potential to cause xerostomia within the research period. No intervention such as: radiotherapy, chemotherapy, surgery that could change the symptoms of xerostomia in the two weeks prior to the survey or during the study period. Eye problems contraindicate the use of parasympathetic agents (eg iridocyclitis, increased intraocular pressure). Other conditions, where there is a risk of worsening of medical problems during the evaluation period (eg severe or uncontrolled asthma or pulmonary disease, hypo or hypertension (uncontrolled), hyperthyroidism, uncontrolled seizures or cardiac arrhythmias, HIV and Hepatitis C). Established oral infections (eg, candidiasis, herpes infections, mucositis, canker sores).Pregnant women and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-26gmvg	Benefits of Epidural block in pain control after liver embolization, compared to venous analgesia	Not yet recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2081	Randomized clinical trial on the effectiveness and benefits of Peridural blocking in the control of Post-embolization syndrome, compared to venous analgesia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Fundação Antônio Prudente	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-26gmvg	<NULL>	Patients of both genders; 18 years or more; submitted to hepatic embolization; consent to the free and informed consent form.	"Absolute contraindications and related to epidural block; patients who remain intubated or are reintubated in the postoperative period; present epidural block failure;
with dialysis renal insufficiency or severe hepatic impairment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-5n9cmf	Evaluation of the effect of Compression Stocking containing Natural Product in the treatment of Ulcers and Varicose Veins	Recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2082	Clinical study randomized, blind, controlled of effect of compression Stocking containing nanoencapsulated Flavonoid in the treatment of chronic venous Insufficiency	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-17	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5n9cmf	<NULL>	Volunteers with varicose veins, varicose veins plus edema, hyperpigmentation, lipodermatosclerosis, healed venous ulcer or active ulcer; age between 30 and 59 years; both genders; similar impairment of the saphenous vein	Volunteers with telangiectasias; cognitive alterations; diabetics; neuropaths; with erysipelas; lymphangitis; deep vein thrombosis; ulcer of non-venous origin; psychiatric disorders; demence; without speaking or understanding the Portuguese language; use of antibiotic or venoactive drugs in the last six months prior to the start of the research; sclerotherapy of lower limbs; surgical procedure; use of Unna boot, multi-layer dressing or dressing with topical medicine; children; morbidly obese; pregnant women; infants; patients at risk of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7dfwct	The effect of auriculotherapy and mechanical vibrations generated on oscillating vibratory platform in individuals Knee arthrosis	Recruiting	Intervention	2018-08-02	<NULL>	<NULL>	2083	Research on the effect of a procedure involving the association one of the Integrative and Complementary Practices (auriculotherapy) in the “Sistema Único de Saúde” and the mechanical vibrations generated in oscillating/vibratory platform in the manangement of individuals with a chronic non-communicable disease (Gonarthrosis)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-05	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7dfwct	<NULL>	Individuals over 18 years of age with Knee osteoarthritis or healthy (no chronic diseases or lesions in lower limbs).	individuals who are taking viscossupplementation and / or corticoids less than 12 months old; individuals currently in another rehabilitation program; individuals with clinical manifestations that did not allow the accomplishment of exercises; individuals with presence of cardiac pacemaker; individuals with recent surgeries in the lower limbs (1 year), individuals with hip or bilateral knee arthroplasty, individuals with rheumatoid arthritis and / or spinal arthrodesis; individuals who refused to sign the Informed Consent Term (TCLE).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9d2ycv	Clinical evaluation of carious dentin in caries lesions in posterior teeth before and after caries removal and the relation with the clinical success of the restoration	Recruitment completed	Intervention	2018-08-02	<NULL>	<NULL>	2084	Clinical evaluation of  carious dentin in out  in primary molars before and after excavation and the relationship with the clinical success of restoration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9d2ycv	<NULL>	Primary teeth occlusal caries in children between three to six years old	Pain history, abcess and periapical lesion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9ftypy	Pain after two different multimodal anesthesia techniques in obesity surgery	Data analysis completed	Intervention	2018-08-02	<NULL>	<NULL>	2085	Pain after two different multimodal anesthesia techniques in bariatric surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Santa Casa de Misericórida de Belo Horizonte	Hospital São José do Avaí	https://ensaiosclinicos.gov.br/rg/RBR-9ftypy	<NULL>	Patients sequentially scheduled for Roux-en-Y Reduction Gastroplasty; age between 18 and 70 years; agreement and signature of the free and informed consent term.	Chronic use of opioids; patients with chronic pain; history of chemical dependence; allergic to any of the medications used in the study; patients with any cardiac, respiratory, renal or hepatic pathology that is considered severe.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-56n3sc	Relationship between the value of suppression of the Bispectral Index and cerebral oximetry through the skin in the occurrence of delirium in cardiac surgery	Recruiting	Intervention	2018-08-02	<NULL>	<NULL>	2086	Correlation of bispectral index suppression index with transcutaneous cerebral oximetry in the occurrence of delirium in cardiac surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Sociedade Literária e Caritativa Santo Agostinho	Sociedade Literária e Caritativa Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-56n3sc	<NULL>	"Physical state ASA II or III;
Patients over 50 years of age;
Elective cardiac surgery with CPB;
Informed consent signed by the patient"	"History of previous stroke;
Degenerative disease of the central nervous system; Mini-mental and / or MoCA &lt;24;
Emergency / emergency surgery;
Patient refusal to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-255fcq	Pain assessment after treatment of channel two different preparation techniques of the root canal	Recruitment completed	Intervention	2016-08-01	<NULL>	<NULL>	2087	Postoperative pain after the use of different kinematics in root canal preparation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-26	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-255fcq	<NULL>	Patients aged 18 to 50 diagnosed with irreversible pulpitis and pulp necrosis in molars that do not show symptoms before starting treatment will be selected for the study.The root canals of the teeth to be treated should present curvature of up to 25 ° measured according with the Schneider method (Schneider, 1971).	Ingestion of any type of medication before treatment; presence of internal or external resorption; periapical pathology; lockjaw; ankylosis; periodontal index score less than 3; systemic disease; Bad severe tooth position; history of trauma; pregnancy; Bad severe occlusion associated with traumatic occlusion; anterior teeth; lack of patient compliance; intolerance history of the anti-inflammatory drugs nonsteroidal; and the presence of teeth that require endodontic retreatment, pre-operative pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-8xtc9c	Use of a smartphone app combined with streaming content and game elements to increase the level of physical activity of adults and older adults	Not yet recruiting	Intervention	2018-08-03	<NULL>	<NULL>	2088	Use of a smartphone app combined with beacons and gamification to increase the level of physical activity of adults and older adults: a sequential multiple assignment randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Federal de São Paulo	Laboratório de Epidemiologia e Movimento Humano - EPIMOV	https://ensaiosclinicos.gov.br/rg/RBR-8xtc9c	<NULL>	Age over 20 years old, without diagnosed cardiorespiratory diseases, musculoskeletal limitations, electrocardiographic abnormalities, or other conditions that preclude the safe practice of physical activity, has to own a smartphone and be familiar with the use of the device.	Basal average level of physical activity &gt;= 10,000 steps per use of walking aids, recent respiratory infections, spirometric abnormalities, stable or unstable angina on the 4 weeks prior to evaluation,  recent myocardial infarction, history of angioplasty or heart surgery, bradycardia or tachycardia, and refuse to participate by signing the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-4tmcrk	Evaluation of the precision of the guided surgery in the installation of implants	Recruiting	Intervention	2018-08-03	<NULL>	<NULL>	2089	Evaluation of the influence of guided surgery on the precision of positioning of single implants in post extraction sockets in the anterior region - Prospective randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4tmcrk	<NULL>	Over 18 years of age; good oral hygiene (plate index &lt;20%); present indication for installation of immediate unitary implants in the anterior region of the maxilla; indication of caries extraction or root fracture; remaining adequate bone levels for installation of unitary implants; present intact neighboring teeth to the area that will receive the implants.	Need for previous surgery to increase bone and / or soft tissue; patients with periodontal disease; patients with top bite or with loss of posterior occlusal support, patients with diseases or systemic conditions or who use drugs that alter bone metabolism; presence of fixed orthodontic appliances, pregnant or lactating women; heavy smokers (Above 10 cigarettes per day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-5bqfyt	Effects of strength-training on Breast Cancer Survivors	Recruitment completed	Intervention	2018-03-08	<NULL>	<NULL>	2090	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in Breast Cancer Survivors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-09	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5bqfyt	<NULL>	Staging history I to III confirmed; age between 40 and 65 years; being in menopause; not being involved in any regular exercise program in the last 6 months; have completed all cancer-related therapies, including, surgery, chemotherapy and / or radiation; be at least 6 months after treatment; hormone therapy (eg tamoxifen or aromatase inhibitor).	Osteomioarticular limitations that could compromise the exercise protocol; uncontrolled chronic disease that could represent a risk to the health of the volunteer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-3qnh96	Clinical trial of facial paralysis treatment.	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2091	Randomized clinical trial without treatment of peripheral facial palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-13	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-3qnh96	<NULL>	Participation of this study patients with medical indication for physical therapy; being in the chronic phase of the PFP with a minimum of 3 months after the injury; of different etiologies; presenting facial muscle dysfunction from Grade II to VI according to the House-Brackmann scale and who agree to be part of the independent study of the therapeutic resource that will be used.	Patients with a diagnosis of PF presenting grade I dysfunction according to the House-Brackmann scale will be excluded from the present study; which are in the initial phase of the disease and have hypersensitivity to phototherapy; skin irritation; eye problems; bacterial processes. Also excluded are patients with bilateral facial involvement and lesions or coarse facial features that may interfere with electrode contact and laser irradiation; with lack of understanding and who are performing other facial treatments simultaneously.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-5hbzf5	The effect of elastic bandage and orthopedic palm in patients with foot inflammation	Recruitment completed	Intervention	2018-08-06	<NULL>	<NULL>	2092	Comparative study between the use of functional bandage and orthopedic palm in the plantar fasciitis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-5hbzf5	<NULL>	Patients of both genders; aged between 20 and 55 years; with clinical diagnosis of plantar fasciitis; with lesion time from 2 months; presenting a misalignment of the medial longitudinal arch (flat foot and cavus) and who agreed to be part of the independent study the therapeutic resource that will be performed after the signing of the free and informed consent term	Patients with other concomitant conditions of the foot and ankle were excluded from the study; with comorbidities such as diabetes mellitus; neuropathies; insensible foot; skin irritation; allergic processes to the tape; patients with previous surgeries who are performing other treatments simultaneously with the treatments proposed in present study and who do not agree to participate in the study after reading the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-78tr7x	Effectiveness of technology for nursing care	Not yet recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2093	Multimedia application to support the systematization of nursing care to the clinical patient	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade de Fortaleza	Laboratório de Tecnologia em Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-78tr7x	<NULL>	Students regularly enrolled in the year 2018; being in the discipline of caring 3 (Semiology)	Students who have previous experiences with anamnesis and physical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7nw8wz	Impact of using an automatic bolus calculator for glycemic control in patients with type 1 diabetes mellitus	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2094	Impact of using an Automatic Bolus Calculator for glycemic control in patients with type 1 Diabetes Mellitus receiving multiple daily Insulin injections	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Irmandade Santa Casa de Misericordia de Sao Paulo	Irmandade Santa Casa de Misericordia de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nw8wz	<NULL>	Patients &gt;16 years old; HbA1c over ou equal to 6.5%; T1DM diagnosis for more than 1 year; being treated with multiple daily insulin injections (MDI); pre-prandial insulin doses adjusted according to carbohydrate count	T2DM or T1DM diagnosis for less than 1 year from the screening date; use of oral hypoglycemic agents, apart from metformin; fixed insulin injections; or using insulin dosage tables according to their blood glucose tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-6yj8sj	Vitamin D action in the treatment of Depression and reduction of Cardiovascular Risk	Not yet recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2095	Vitamin D Action in Depression and Cardiovascular Risk in Outpatient Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6yj8sj	<NULL>	"Adults in the age group of 18 to 59 years;
Both sexes;
People with depression;
Attended in psychiatric outpatient clinics;
In treatment with antidepressants"	Exclusion Criteria: patients who are already being supplemented with vitamin D, with a personal history of psychiatric comorbidities, chronic kidney disease, hypercalcemia, neoplasias and pregnant women or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-3cz6jg	Clinical characteristics of a group of smokers in a smoking cessation program	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2096	Clinical and epidemiological profile of a group of smokers in a smoking cessation program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Escola Baiana de Medicina e Saúde Pública	Escola Baiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cz6jg	<NULL>	Smoker. Over 18 years old. Sign the term of Free consent	Carrier of serious heart disease. Carrier of mental disorders. Do not sign the Term of Free Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9b4gwz	Analysis of the type of patient submitted to heart surgery and the period during and after surgery at Hospital and Maternity Marieta Konder Bornhausen	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2097	Analysis of the surgical profile and the immediate postoperative and postoperative period of patients submitted to cardiac surgery at the Hospital and Maternity Hospital Marieta Konder Bornhausen	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade do Vale do Itajaí	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-9b4gwz	<NULL>	Patients (or caregivers) who signed the ICF, who were hospitalized in an intensive care setting after cardiac surgery.	Patients who underwent mechanical ventilation for more than 24 hours; patients who did not tolerate the use of the NIV mask; protocol follow-up error	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-2njhwn	Impact of stomach reduction surgery on salivary composition and cytomorphology of oral mucosa: follow-up three and six months	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2098	Impact of gastroplasty on salivary composition and cytomorphology of oral mucosa: follow-up three and six months	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2njhwn	<NULL>	The inclusion factors will be: young adults between the ages of 18 and 40, of both sexes, with indication of gastroplasty	The exclusion factors of the sample will be: diagnosis of chronic diseases such as epilepsy, cancer, rheumatoid arthritis; bucco-dentofacial diseases or trauma; use of tobacco or illicit drugs; Diseases that alter the quantity and quality of secreted saliva, such as Sjögren&apos;s syndrome, systemic lupus erythematosus and sarcoidosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9jp5sj	Application of light at acupuncture points in the treatment of pain in children with sickle cell disease	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2099	Application of LASER acupuncture in the treatment of pain in children with sickle cell disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-06	Núcleo de Estudo em Saúde e Funcionalidade	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-9jp5sj	<NULL>	Patients with sickle cell disease confirmed by laboratory examination (falcization or hemoglobin electrophoresis test); report of joint pain in hematological consultation ; written proof of the authorization of the person responsible for inclusion in the study by signing a Free and Clarified Consent Term.	Previous history of fracture for a year or less, previous history of osteomyelitis, rheumatic fever, rheumatoid arthritis, leukemia, malignant neoplasm, child with cerebral palsy , making use of opioids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4tq9yq	Effect of Curcumin associated with LED application in the treatment of residual pockets of patients with Chronic Periodontitis and type 2 Diabetes Mellitus	Recruitment completed	Intervention	2018-08-06	<NULL>	<NULL>	2100	Photodynamic effects of Curcumin in the treatment of residual pockets in patients with Chronic Periodontitis and type 2 Diabetes Mellitus: a randomized split-mouth trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-23	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-4tq9yq	<NULL>	Patients with age equal to or greater than 30 years and less or equal than 70 years (MATARAZZO et al., 2008); diagnosis of chronic periodontitis that have undergone periodontal treatment in a period of 3 to 6 months, with at least 4 sites with probing depth (PD) bigger or equal than 5 mm and loss of clinical attachment (CAL) bigger or equal than 3 mm with bleeding on probing (BOP) (APP, 2015); patients diagnosed with type 2 diabetes mellitus (HbA1c equal to or greater than 6.5%) (SACKS et al., 2011); present at least 15 teeth, excluding third molars (ASSEM, 2015); at least 1 site with PD equal to or greater than 5 mm (residual pocket with bleeding on probing) per quadrant.	Smokers or ex-smokers for more than 12 months; patients with anemia; patient with active cancer and history of chemotherapy; history of antibiotic therapy in the previous 6 months; history of anti-inflammatory therapy in the last 6 months; patient with blood disorders; pregnancy; patient in orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7szm34	Impact of Early Mobilization on Sepsis Patients: influence of Passive and Active Exercises on the cardiovascular and inflammatory systems	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2101	Impact of Early Mobilization in Sepsis Patients: influence of Exercise on endothelial function, cardiac autonomy and inflammatory profile	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7szm34	<NULL>	Clinical diagnosis of sepsis.	atrial fibrillation;pre-existing atrioventricular block or ventricular tachycardia; recent myocardial infarction (&lt;6 months);patients with pacemaker; stroke; signs of intracranial hypertension; cranioencephalic trauma; neuromuscular disease; Body mass index (BMI) greater than 40; patient with neoplasia undergoing chemotherapy and unconsolidated fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7b8yh8	Impact of meditation practice on stress response, attention and emotion in a healthy population	Recruitment completed	Intervention	2018-08-07	<NULL>	<NULL>	2102	Impact of mindfulness based practice on stress response, emotional regulation, interoception and attention in a healthy sample	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7b8yh8	<NULL>	Age between 18 and 35 years old; Do not present any psychiatric disease (depression, schizophrenia, general or social anxiety). Do not use any psychotropic medication. Do not have experience with meditation. Sign the consent term	Miss one day of intervention (brief intervention); Miss three consecutive sessions (long intervention); Manifest any infectious disease during the study (brief intervention); Body mass indice higher than 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-8bdqzd	Cancer frequency among children and adults carrying or not a hereditary mutation that facilitate Cancer development, taking into consideration the diversity of the rural or urban environment where they live	Recruiting	Observational	2018-08-07	<NULL>	<NULL>	2103	Neonatal Screening, Mapping of the TP53 R337H mutation prevalence per municipality, Cancer history, socioeconomic profile and molecular alterations associated with tumors in the families	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Associação Hospitalar de Proteção à Infância Dr Raul Carneiro	Instituto de Pesquisa Pelé Pequeno Príncipe	https://ensaiosclinicos.gov.br/rg/RBR-8bdqzd	<NULL>	Newborn positive for mutation TP53 R337H; relatives of the positive newborn on the parental side who inherited the TP53 R337H mutation; both genders; age between 1 day and 120 years.	Relatives of the parental side who did not inherit the mutation TP53 R337H.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-5stpwb	Lung protective mechanical ventilation versus regular mechanical ventilation in patients undergoing vascular surgery of the lower limbs.	Recruitment completed	Intervention	2018-08-07	<NULL>	<NULL>	2104	Protective versus conventional mechanical ventilation for peripheral vascular surgery: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-15	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5stpwb	<NULL>	Adult ASA II to IV patients; older than 18 years; scheduled to undergo arterial bypass surgery in the lower limbs.	Patients with a body mass index above 40 kg / m2; submitted to emergency surgery; with a history of pulmonary surgery; persistent hemodynamic instability in the preoperative period; history of asthma or chronic use of corticosteroids; or patients with a history of neuromuscular disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-3h6q4c	Massage effects on  recovery process of signs and symptoms triggered by exercise in  the elbow flexors muscle	Recruitment completed	Intervention	2018-08-09	<NULL>	<NULL>	2105	Massage effects on recovery of muscle damage induced by exercise in the elbow flexors muscle	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Educação Física - UnB	Universidade de Brasíia	https://ensaiosclinicos.gov.br/rg/RBR-3h6q4c	<NULL>	Healthy and physically active men; age between 18 and 25 years; have no lesions on the lower limbs or functional limitations that impede the performance of the tests.	Will be excluded  volunteers with any osteomioarticular involvement of lower limbs as well as cardiovascular, respiratory disease and angina. Also will be excluded participants taking medications that could affect muscle function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4p6fk2	Physical exercise with limitation of blood flow to the forearm in renal patients: randomized clinical trial	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2106	Efficacy of physical exercise with restriction of blood flow on the blood vessels of the forearm pre and post-confection of arteriovenous fistula in Chronic Kidney Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	Universidade Federal da Pernambuco	Universidade Federal da Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4p6fk2	<NULL>	The study will include patients with stage 4 or 5 chronic kidney disease; of both sexes, aged between 18 and 60 years; in conservativ treatment or dialysis; and who have medical indication for the manufacture of arteriovenous fistula for the performance of hemodialysis.	Those that present cognitive deficits that may interfere in the understanding of the evaluation process or the accomplishment of the activities will be excluded; patients with a history of arteriovenous fistula production in the upper limbs or who have undergone previous local vascular procedure; those that perform manual activity with high loads; and that presented traumatic-orthopedic injuries in cervical, shoulder, elbow, wrist and hand; and those with signs of thrombophlebitis and hypoplasia / agenesis of the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7sxmn7	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of wounds in lower members	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2107	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of trophic lesions in lower members	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Fundação Educacional da Região de Joinville-UNIVILLE	Fundação Educacional da Região de Joinville-UNIVILLE	https://ensaiosclinicos.gov.br/rg/RBR-7sxmn7	<NULL>	"Older than 18 years; both genders; voluntarily agree to participate; sign the
Term of Free and Informed Consent; present trophic lesions in lower limbs with more than 30 days duration; Wounds with 1cmx1cm at 8cmx8cm; not submitted to hyperbaric oxygen therapy."	"Trophic lesions of lower limbs smaller than 1cm x 1cm or larger
8cmx8cm; submitted to hyperbaric oxygen therapy; voluntary withdrawal at any time during the research"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-45wjx4	Root canal treatment x retreatment: microbial profile and signs and symptoms	Recruitment completed	Intervention	2018-08-09	<NULL>	<NULL>	2108	Primary X secondary endodontic infections: microbial and profile, endotoxins and lipoteicoic acid levels	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-12	ICT - Universidade Estadual Paulista Júlio de Mesquita Filho	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-45wjx4	<NULL>	Unirradicular tooth of patients requiring endodontic treatment; teeth with pulp necrosis and presence of periapical lesion; need for endodontic retreatment; age range from 21 to 60 years of age, favorable health conditions, local and systemic; unirradicular teeth with unsatisfactory prior endodontic treatment performed 3 years ago or more; presence of periapical lesion visible	Periodontal disease; root fracture, exposure of the pulp chamber to the mouth; patients who used antifungals and antibiotics in the period of three months before the endodontic treatment; impossibility of absolute isolation were not included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-4ybjmt	Evaluation of therapies to reduce the sensitivity of teeth in dental lesions located near the gun	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2109	Evaluation of desensitizing therapies in Non-carious cervical lesions - randomized clinical trial, double -blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de Brasília	Corpo de Bombeiros Militar do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-4ybjmt	<NULL>	Patients who present at least one LCNC with HDC; Both sexes; Age range: from 18 to 60 years; Do not have had home treatment in the last month with dentifrices / pastes / creams or mouthwashes indicated for the treatment of dentine hypersensitivity, having in their composition: potassium nitrate, oxalates, strontium, bicarbonate of arginine or 5000 ppm / F; Not having performed office treatment with desensitizing agents for professional use such as lacquer, gels and laser therapy in the last month; Do not use anti-inflammatory or analgesics during treatment	Patients with LCNC, but without HCD; Use of continuous anti-inflammatory and analgesic medications; Use of orthodontic appliance; Presence of periodontitis or active carious lesion; Pregnant or nursing; Continuously use toothpaste / paste / creams or mouthwashes indicated for the treatment of dentine hypersensitivity, having in their composition: potassium nitrate, oxalates, strontium, arginine bicarbonate or 5000 ppm / F; Very deep LCNCs being possible to visualize the shade of the pulp chamber, indicated restorative treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-4qvfwf	Prolonged slow expiration technique in Preterm infants with Bronchopulmonary Dysplasia: is there some benefits comparing with conventional technique?	Data analysis completed	Intervention	2018-08-10	<NULL>	<NULL>	2110	Techiniques of Physical therapy respiratory and food performance of Newborn with preterm Dysplasia Bronchopulmonary	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de Santa Maria	Hospital de Caridade Dr Astrogildo de Azevedo	https://ensaiosclinicos.gov.br/rg/RBR-4qvfwf	<NULL>	prematurity; bronchopulmonary dysplasia	malformations head, neck and / or heart; genetic syndromes; intracranial hemorrhage (ICH) grade III and IV; perinatal asphyxia (Apgar score &lt;5 at 5 minutes of life); bilirubin encephalopathy, shortened frenulum of the tongue and not parental consent and / or legal guardians for the child&apos;s participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-6jhqzd	Effect of Botox Treatment on the quality of life of patients with teeth grinding and pain in the Temporomandibular Joint	Recruitment completed	Intervention	2018-08-10	<NULL>	<NULL>	2111	Effect of Botulinum Toxin Treatment on the quality of life of patients with bruxism and pain in temporomandibular joint	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Uberlândia - UFU	Universidade Federal de Uberlândia - UFU	https://ensaiosclinicos.gov.br/rg/RBR-6jhqzd	<NULL>	Pacients with bruxism.Agree to participate and sign the informed consent form (TCLE)	"Existence of active psychosis, another active or cognitive impairment, existence of serious co-morbid conditions, individuals
who have had exposure to any botulinum toxin preparation in the last 6 months, participation in another experimental therapeutic protocol, any medical condition in which the administration of the toxin
botulinum toxin is contraindicated, including myasthenia gravis, amyotrophic lateral sclerosis and other
acute history of dysphagia, history of botulism, a condition or the situation in which the investigators
confusion in the subject&apos;s ability to participate in the study, inability to understand and sign informed consent, pregnancy, do not meet inclusion criteria and individuals who are hypersensitive to any component of the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-4q53d6	Theory of chaos applied to spinal anesthesia	Recruitment completed	Intervention	2018-08-10	<NULL>	<NULL>	2112	Fractal and chaotic behavior of heart rate variability in subarachnoid anesthesia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Hospital Universitário Júluio Bandeira	Hospital Universitário Júluio Bandeira	https://ensaiosclinicos.gov.br/rg/RBR-4q53d6	<NULL>	Patients with physical status ASA I, II or III submitted to orthopedic surgical procedure of lower limbs under spinal anesthesia. By orientation and signature of the TCLE. Aged between 14 and 99 years. Sample : 60 patients.	Patients who use beta blockers or other drugs and conditions that alter the autonomic balance. Patients who refused to sign the EHIC. Patients with bleeding loss expected above 500 ml. General anesthesia, peripheral nerve blocks, epidural.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-43vpmr	Assessment of skin and scar quality after Fat Infiltration	Data analysis completed	Intervention	2018-08-10	<NULL>	<NULL>	2113	Assessment of skin and scar quality after Fat Grafting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Pernambuco - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-43vpmr	<NULL>	Women; abdominoplasty indication; between 20 and 50 years; BMI below 30; previous cesarean scar.	Smokers; patients with systemic disease; use of any medication for chronic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-463sk7	Follow-up of patients submitted to dental implant and prostheses rehabilitation	Recruiting	Observational	2018-08-10	<NULL>	<NULL>	2114	Longitudinal study of patients submitted to dental implant installation and implant retained prostheses	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-463sk7	<NULL>	To present dental absence (total or partial) that indicates the insertion of dental implant and posterior confection of dental prosthesis; To present good general state of health, that allows the accomplishment of the surgery of dental implant; Availability of time and time to attend dental appointments at the institution.	Systemic disease that prevents the accomplishment of the surgery; Unavailability to be treated at the institution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-72dvqv	Effects of açaí consumption on the health of individuals with excess weight and changes in blood fats.	Recruitment completed	Intervention	2018-08-10	<NULL>	<NULL>	2115	EFFECT OF AÇAÍ CONSUMPTION IN THE ANTIOXIDANT STATE IN THE ANSWER INFLAMMATORY AND EXPRESSION OF MICRO-RNAS IN INDIVIDUALS WITH EXCESS OF WEIGHT AND DISLIPIDEMICS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-72dvqv	<NULL>	overweight adults of both sexes, over 20 years of age, and who have dyslipidemia.	Individuals with aversion or food allergy known to açaí; Pregnant and lactating women, since the caloric restriction is not part of the food planning in these physiological conditions;  Self-reported alcoholism, as it is related to the increase in blood pressure and to alter the concentration of serum lipoproteins that are parameters in the diagnosis of dyslipidemia; Individuals on an energy restriction diet or using dietary supplements containing minerals or antioxidant vitamins, as part of the present study weight loss and antioxidant supplementation, therefore, this aspect may interfere in the results of this study; Individuals with autoimmune, infectious, cancer and AIDS diseases that may interfere with the results of the present study;  Thyroid diseases untreated and destabilized, since the thyroid regulates body metabolism, so in case of disease it may interfere in the results of the present study;  Chronic renal failure or hepatopathies, because they are diseases that compromise the whole inflammatory state and oxidative stress, besides needing nutritional care that the protocol stipulated in this project is not able to supply; Use corticosteroid substances, as it interferes with the metabolism of glucose, causing hyperglycemia and edema, which may interfere with the results of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7qnffg	The effect of muscle strengthening of the calf on the walking of children with toe walking.	Not yet recruiting	Intervention	2018-01-29	<NULL>	<NULL>	2116	The effects of muscle strengthening of the plantar flexors on the gait pattern of children with idiopathic toe walking.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal de São Paulo	Instituto de Assistência ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qnffg	<NULL>	The inclusion criteria will be: children between 5 and 11 years of age; of both sexes; diagnosed with idiopathic toe walking; that present gait in equine; with bilateral involvement and that do not present any neurological or psychiatric impairment.	The exclusion criteria will be: children under 5 years and over 11 years of age; with structural ankle deformity in equine (inability to reach the ankle neutral position passively); with central or peripheral neurological impairment; who are unable to minimally understand the questions used during the evaluations; which have undergone surgery in the lower limbs or who have undergone the application of botulinum toxin in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-528pyq	Comparison of active videogames And running practices on Endothelial, Inflammatory, Cardiovascular And Metabolic Parameters in Type 1 Diabetes people	Data analysis completed	Intervention	2018-08-13	<NULL>	<NULL>	2117	Active video vames: A coadjuvant in the treatment of Diabetes Mellitus types 1 and 2?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-528pyq	<NULL>	Were included male and female subjects Patients who regularly use insulin and do not use anceolytics; anti-inflammatories; antibiotics and or beta-blockers; do not have an osteo-articular; muscular restriction; peripheral neuropathy or any involvement or complication caused by diabetes that prevents the sessions.	All DM1 were excluded who initiate the practice of other physical exercises during the period of study will be excluded, obtain any type of complication that may be aggravated by VGA practice or by medical report, requesting the absence exit of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-9kr2jb	Benefits of Functional Training for the elderly	Recruitment completed	Intervention	2018-08-14	<NULL>	<NULL>	2118	The effect of Functional Training on physical fitness, functional capacity and lumbar pain reports in older women: clinical testing	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9kr2jb	<NULL>	Healthy elderly; aged 60-69 years, women; not physical exercise; autonomous	Bracing or prosthesis holders; difficulties for the cognitive domain; practitioner of physical exercises; not assiduous during functional training intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-923s3w	Functional skills and caregiver assistance in children and adolescents with autism using virtual reality	Recruiting	Intervention	2018-08-15	<NULL>	<NULL>	2119	Characterization of functional abilities and caregiver assistance in children and adolescents with autism spectrum disorder submitted to virtual reality	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade de São Paulo Leste - Escola de Artes, Ciências e Humanidades	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-923s3w	<NULL>	The signing of a free and informed consent by the parents or guardians of the minors; signature of the term of assent by the minor; mild and moderate degree diagnosed by a child neurologist and multidisciplinary team of the institution, will include people with autism who attend between 1st and 5th grade elementary school	Severe autism; comorbidities such as Attention Deficit Disorder with Hyperactivity and Down Syndrome; withdrawal during the protocol; functional deficiencies that impede the accomplishment of the task	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-67hvhy	Evaluation of treatment for the heart on the sensation of pain in people who are hypertensive	Data analysis completed	Intervention	2018-08-15	<NULL>	<NULL>	2120	Evaluation of a cardiac rehabilitation program on the nociceptive threshold in hypertensive individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-02	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-67hvhy	<NULL>	Individuals with a diagnosis of hypertension; Normotensive individuals; Both sexes; Adults over 40 years.	History of unstable angina, thrombophlebitis, recent embolism, infection, atrioventricular block (without pacemakers), acute myocarditis or pericarditis, arrhythmias, untreated mitral stenosis, decompensated heart failure, uncontrolled hypertension, ST segment depression, diabetes mellitus uncontrolled, fever, smokers, use of continuous analgesic, antidepressants, tranquillizers or any medication that could interfere with the nociceptive threshold, drugs and alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-2rcph2	Effects of diet on the intestinal health of patients with liver fat	Recruitment completed	Intervention	2018-08-15	<NULL>	<NULL>	2121	Effects of Nutritional Intervention on the nutritional profile, inflammation and intestinal health of outpatients with Hepatic Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-02	Faculdade de Medicina de Universidade Federal de Juiz de Fora	Faculdade de Medicina de Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2rcph2	<NULL>	Age greater than 18 years; both genders;  previous diagnosis of non-alcoholic steatohepatitis by means of liver biopsy.	Presence of chronic hepatitis B; chronic hepatitis C; autoimmune diseases of the liver; hemochromatosis; HIV-1 and 2-infected patients; patients with drug-induced; alcohol-induced liver disease (greater than 30 g / day in men or greater than 20 g / day in women); use of antibiotics in the two months prior to inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-5q5dg8	Oral Polypodium Leucotomos and Ingenol Mebutate  gel 0.05% or Colchicine cream 0.5% in the treatment of Solar Queratoses	Not yet recruiting	Intervention	2018-08-15	<NULL>	<NULL>	2122	Oral Polypodium leucotomos versus placebo associated to Ingenol Mebutate 0.05% gel or Colchicin 0.5% cream in treatment of Actinic Keratoses and Skin Field Cancerization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Medicina - Unesp Botucatu	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-5q5dg8	<NULL>	"Sign the Term of Free and Informed Consent;
• Age above 18 years of both sexes;
• Present at least three and at most ten lesions clinically compatible with actinic keratosis in each forearm, bilaterally."	"Injuries less than three or greater than ten in each forearm;
Selected treatment area that has atypical clinical appearance or other extensive dermatoses on the forearms;
Current and prior clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment;
To show hypersensitivity or allergy to any of the studied sub-substances;
Patients on any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (eg corticosteroids, anti-inflammatories, retinoids);
Immunocompromised individuals;
Coagulation disorders;
Suspected or confirmed pregnancy;
Women of childbearing potential who do not use contraceptive methods;
Women in the breastfeeding phase."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7cyp6t	Epidural anesthesia with ropivacaine and its effects in the duration of the muscular relaxation produced by rocuronium.	Data analysis completed	Intervention	2018-08-17	<NULL>	<NULL>	2123	Epidural Adminstration of ropivacaine and its effects on the pharmacodynamics of rocuronium: randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-03	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7cyp6t	<NULL>	Elective Abdominal Surgeries performed under general anesthesia with or without association of epidural analgesia; female sex; age between 18 and 65 years old. Use of neuromuscular blocking agents; physical state ASA 1 and 2.	neuromuscular, renal and hepatic diseases; BMI greater than 32.5 or less than 20.0 kg.m-2; hydroelectrolytic and acid-base disorders; use of drugs that interact with neuromuscular blockers; contraindication to spinal blocks; history of hypersensitivity to drugs used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-2phxzm	Mouthwashes for treatment of nas breath	Data analysis completed	Intervention	2018-08-17	<NULL>	<NULL>	2124	Chemical control of oral halitoses by mouthwashes: evaluation by gas chromatography and organoleptic test	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-04	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2phxzm	<NULL>	"Presence of at least 20 natural teeth;
Good oral hygiene;
Absence of periodontal disease, xerostomia, or any chronic inflammatory process;
Patients with halitosis of intra-oral cause."	"Smokers;
Alchoolics;
Pregnant or lactating;
Carriers of systemic diseases (hepatic, renal, diabetes);
Presence of pharyngeal or tonsillar infection;
Upper or lower respiratory tract inflammation;
Carriers of removable prostheses, clinically unsatisfactory fixed prostheses, dental caries, lesions on the buccal mucosa;
Individuals who have used antibiotics in the last 3 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5x762v	Vitamin A and Zinc Supplements in the Treatment of Visceral Leishmaniasis	Recruiting	Intervention	2018-08-17	<NULL>	<NULL>	2125	Effects of Supplementation with Vitamin A and Zinc in the Treatment of Visceral Leishmaniasis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Ministério da Educação	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-5x762v	<NULL>	Adult patients of both genders and children of six months of age or more; presenting the following requisites: diagnostic of visceral leishmaniasis in treatment, made at the Natan Portela Institute for Tropical Diseases IDTNP in Teresina, Piaui, Brazil, located at Rua Governador Raimundo Artur de Vasconcelos 151 Sul.	Patients with hematological malignancies; patients undergoing chemotherapy; children under six months of age; pregnant women; children who have received vitamin A supplementation in the last six months; patients who are bedridden or to swallow.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-4qb6y7	Modality of Athletics against overweight and Obesity of Adolescents.	Recruitment completed	Intervention	2018-08-20	<NULL>	<NULL>	2126	Efficacy of physical exercise (athletics modality) in coping with overweight and obesity in adolescents.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4qb6y7	<NULL>	Adolescents; overweight and obesity; ages between 13 and 18 years; students of the School of Elementary and Middle School Antônio de Almeida Lustosa.	Age under 13 years or above 18 years of age; orthopedic problem; problems that prevent them from participating in the exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-62b4z2	Relationship of changes in heart rate with stress test results in patients with Chronic Obstructive Pulmonary Disease	Data analysis completed	Observational	2018-08-20	<NULL>	<NULL>	2127	Correlation of cardiac frequency variability and ergoespirometry in patient with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-18	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-62b4z2	<NULL>	We selected patients with moderate to severe chronic obstructive pulmonary disease, former smokers of both genders, who completed a pulmonary rehabilitation program with a minimum of eight weeks	Patients who did not complete the eight-week rehabilitation program, patients who require oxygen during ergospirometry, or who are unable to participate in the study, were excluded from the study. Patients with mild impairment of Chronic Obstructive Pulmonary Disease, or with associated heart disease, understand or perform the research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-6pcrfm	Light strength exercise associated with Partial Occlusion of blood in the treatment of knee osteoarthritis	Not yet recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2128	Very low load and low volume exercise associated with Partial Vascular Occlusion in the knee osteoarthritis treatment: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6pcrfm	<NULL>	Are 50 years of age or more; Have a body mass index (BMI) of up to 35 kgm-2; Have moderate to very severe knee osteoarthritis (score between 5 and 13 on the Lequesne Questionnaire); Have score of 24 or more on Mini-Mental State Examination; Do not have peripheral vascular disease, systolic blood pressure greater than 160 or smaller than 100mmHg, diastolic blood pressure greater than 100mmHg, deep vein thrombosis, history of myocardial infarction, stroke in the last year or history of cancer; Do not have other orthopedic problems that affect gait and do not present other inflammatory myoarticular or neurological diseases; Have not undergone surgery or any invasive procedure for the knees in the last 6 months; Not participating in physiotherapeutic treatment or lower limb strengthening programs in the past three months; Not practicing regular physical activity (two or more times per week) for lower limbs (except for those who only practice walking).	Experience pain that prevents completely the exercises proposed by two consecutive sessions or three non-consecutive or who refuse to remain in the study; Begin taking medications that interfere with study outcomes or begin to exercise or other treatment modalities for knee OA after the initiation of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-4x3cnp	"Implementation of HIV Pre-exposure Prophylaxis (PrEP) for men who have sex with men and transgender individuals at high risk for HIV infection: 
A Demonstration Project in the context of Combination Prevention in Brazil, Mexico and Peru"	Recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2129	"ImPrEP - Implementation of HIV Pre-exposure Prophylaxis (PrEP) for men who have sex with men and transgender individuals at high risk for HIV infection: 
A Demonstration Project in the context of Combination Prevention in Brazil, Mexico and Peru"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-07	Instituto Nacional de Infectologia vandro Chagas (INI) - Fiocruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4x3cnp	<NULL>	"Male sex (at birth), except for transgender male; Willing and able to provide written informed consent; Age 18 years or older; HIV-1-uninfected defined as: Rapid HIV test negative at the enrollment visit; Evidence of risk for acquiring HIV-1 infection including any one of the following: a.	Condomless anal sex with male or transgender sex partners during the last 6 months; or b.	Anal sex with at least one HIV+ partner during the last 6 months; or c.	Reported rectal or urethral gonorrhea or chlamydia or syphilis in the 6 months prior to enrollment or diagnosed at enrollment; or d.	Reporting to exchange sex for money, gifts, shelter or drugs in the last 6 months; No previous history of renal disease."	Signs or symptoms of acute HIV infection; Creatinine clearance &lt; 60 ml/min as estimated by the Modification of Diet in Renal Disease (MDRD) formula; Previously diagnosed active and serious infections, including tuberculosis or osteomyelitis and all infections requiring parenteral antibiotic therapy (other than STIs requiring intramuscular injections of antibiotics); active clinically significant medical problems including poorly controlled cardiac disease (e.g., symptoms of ischemia, congestive heart failure), or previously diagnosed malignancy expected to require further treatment; History of pathological bone fractures not related to trauma; Receiving ongoing therapy with any of the following: ART, including nucleoside analogs, non-nucleoside reverse transcriptase inhibitors, protease inhibitors (except for antiretrovirals used for PEP) or investigational anti-retroviral agents, interferon (alpha, beta, or gamma) or interleukin (e.g., IL-2) therapy, agents with significant nephrotoxic potential, other agents that may inhibit or compete for elimination via active renal tubular secretion (e.g., probenecid), and/or other investigational agents; Concomitant participation in a clinical trial using investigational agents, including placebo-controlled clinical trials using such agents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5hzq77	Good bacterias in gingival disease	Data analysis completed	Intervention	2018-08-20	<NULL>	<NULL>	2130	Introduction of probiotics in periodontal therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Estadual do Rio de Janeiro	Rit Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-5hzq77	<NULL>	The  participants  according  to  the  inclusion  criteria  were  patients  with  chronic periodontitis with at least 20 teeth and Probing Pocket Depth (PPD) 5 mm in at least 6 sites	Without systemic diasease; no periodontal treatment in the last 24 months; without the use of  antibiotics  in  the  last  6  months;  without  pregnancy;  without  orthodontic  therapy;  non-smokers; no cardiac pacemaker users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-59g3wf	Anesthetic properties of two solutions used in the injection technique with less dense bone and greater penetration with the use of electronic injector	Not yet recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2131	Anesthetic properties of two solutions in the Alveolar Crest Technique Spongeous Bone Zone using injector	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-59g3wf	<NULL>	Be between 18 and 35 years of age; Patients of both sexes; Patients who were not submitted to blockade anesthesia in the region in the two weeks prior to the study; Do not use any medication of action of the central nervous system; ASA I and II patients with no history of hypersensitivity to the drugs under study; Present units 36 and 46 in need of restorative treatment;	Pregnant women; History of psychiatric illness that may compromise the ability to provide informed consent; History of drug dependence or abusive alcohol consumption; Odontophobic; Patient ASA III and IV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-3ys6h4	"Effect of a nutritional education program on 
patients with  genetic high cholesterol  quality of life"	Recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2132	Effects of HIPERCOL program on patients with heterozygous Familial Hypercholesterolemia quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-19	Instituto Nacional de Cardiologia- INC	Instituto Nacional de Cardiologia- INC	https://ensaiosclinicos.gov.br/rg/RBR-3ys6h4	<NULL>	Patients with familial hypercholesterolemia genetic diagnosis performed by Brazilian`s Heart Institute (INCOR) e attending to cardiological treatment in National Institute of Cardiology-Brazil.	"Oral feeding difficulties;
clinical suspicion or diagnosis of hepatopathy and nephropathy in dialysis; oncological patients or patients undergoing gastroplasty; previous organ transplantation; wheelchair users; congestive heart failure; postoperative cardiac surgery (30 days); nutritional follow-up in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2zx53z	Study of Vitamin D and Statins on Vascular Function in hypertensive patients	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2133	Study of Vitamin D and 3-Hidroximetilglutaril CoA redutase inhibitors administration on Endothelial Function and Renin-Angiotensin-Aldosterone system in patients with Hypertension: a double-blind placebo-controlled study	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2016-07-01	Unifesp - Universidade Federal de São Paulo	SBIAE - Sociedade Beneficente Israelita Brasileira Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-2zx53z	<NULL>	Volunteers with essential hypertension, without hypertension related organ damage. Between 18 and 75 years old.	Patients previously with: Diabetes mellitus; Autoimunne disease; Neurologic Degenerative disease; Calcium or phosphate metabolism disease; Clinical need of lipid lowering drug prescription. Beside these: Patients who refuse to sign in voluntary consent letter; Patients with severe Hypertension (Sys &gt; 180mmHg / Dias &gt;110mmHg); Patients with hypertensive organ related damage or patients with secundary hypertension diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-73xp36	Immediate effect of the virtual reality game for the upper limb on the brain and muscular activity in the patient after stroke.	Data analysis completed	Intervention	2018-08-21	<NULL>	<NULL>	2134	Evaluation of central and peripheral excitability in individuals submitted to neurological rehabilitation for the paretic upper limb after stroke.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-25	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-73xp36	<NULL>	Inclusion criteria were to present clinical diagnosis of ischemic or hemorrhagic stroke; being in the chronic phase of the disease with an occurrence of more than 3 months; presence of left or right hemiparesis; being of both sexes; regardless of ethnicity, race, and socioeconomic-cultural level, and to present mental competence assessed by the Mental State Mini-Exam.	Low level of mental competence; present hemiplegia or severe spasticity (assessed by Modified Ashworth scale - grade 4), and make use of a myorelaxant medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5f8xwb	Clinical and radiographic evaluation of the survival of the implants, conditions of the tissues around the implants and conditions associated with the effectiveness of treatment in patients rehabilitated with fixed lower denture on implants	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2135	Clinical and radiographic evaluation of the survival of the implants, conditions of peri-implant tissues and conditions associated with the effectiveness of treatment in patients rehabilitated with full-arch mandibular fixed prostheses	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5f8xwb	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use and a maximum of one (1) year.	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy; younger than 18 years; torque of the implant less than 45Ncm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-9s53kh	Evaluation of the Health of Bone and Soft Tissues around the implants of the patients who were treated with Implants and Removable or Fixed Prostheses on them	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2136	Evaluation of Peri-plantar Health in patients rehabilitated with Overdentures and Fixed Implant Prosthesis.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9s53kh	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use.	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy; younger than 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-3zty4w	Effects of active videogame system on health of children with Cerebral palsy	Recruitment completed	Intervention	2018-08-21	<NULL>	<NULL>	2137	Effects of intervention with virtual reality on the health condition of children with cerebral palsy - randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3zty4w	<NULL>	"Children to five througth twelve years old.
Diagnosis of cerebral palsy. Gross Motor Function Classification System GMFCS) I and II.
They are able to understand simple verbal commands."	"Children who do not fit the specific age group.
With bone deformities and muscle shortening limiting for the activity. Who have undergone surgery in the last year. Who have made use of botulinum toxin in the last six months. Who have sensory deficiencies (visual and / or auditory) not corrected by devices. Cardiorespiratory limitations of any intensity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-9337nv	Nursing intervention to reduce symptoms in cancer patients	Data analysis completed	Intervention	2018-08-22	<NULL>	<NULL>	2138	Multimodal nursing intervention to reduce  cancer treatment related symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-23	Escola de Enfermagem da Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9337nv	<NULL>	Breast cancer; colorectal cancer or prostate cancer; be treated with chemotherapy or radiation; older than 18 years; minimum education of four years; not present language dysfunction and oriented in time and space.	Patients illiterate or with cognitive disabilities (dementia / psychosis); patients with high demand for care (Karnofsky score of &lt;40).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-52shjp	Prevention of body temperature drop during surgery, using different models of heaters.	Data analysis completed	Intervention	2018-08-22	<NULL>	<NULL>	2139	Prevent  perioperative hypothermia using diferent heathing method	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-20	Faculdade de Ciencias Médicas da Unicamp	Faculdade de Ciencias Médicas da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-52shjp	<NULL>	Patients subjected to gastroenterológicas elective surgeries; of both sexes; Aged between 18 years and 60 years; With physical state Ps1-PS4, according to ASA-PS American Society of Anesthesiologists physical state	Patients with IMC less than 20 greater than 30; extremes of age; Initial body temperature tympanic below 36 °c or equal to or greater than 38 °c; Transfusion of more than two bags of only; Replacement volume more than 30% of the recommended by the local anesthesia service,15 ml/kg 1st-hour weight, 10 ml/kg subsequent weight and patients in which the surgical dryness proposed in the study objective was not performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2b8p4n	The effect of a substance in Green tea in the decrease of compounds formed in the food preparation process that affect human health	Recruitment completed	Intervention	2018-08-22	<NULL>	<NULL>	2140	Effect of Epigallocatechin-3-Gallate on serum concentrations of Carboxymethyl-Lysine in Inflammation, Insulin Resistance and Endothelial dysfunction caused by acute ingestion of a meal high in advanced glycation end products	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-20	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2b8p4n	<NULL>	Female; healthy; eutrophic (BMI between 18.5 kg / m2 and 24.9 kg / m2) and age between 18 and 25 years.	Cardiovascular, pulmonary or metabolic diseases; use of anti-inflammatory medications and corticosteroids; food restrictions related to the meal used in the study (potato chips, bacon and Parmesan cheese); pregnant and / or lactating; smoker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2hz3tg	Effect of administration  beneficial bacteria on the health in overweight women	Data analysis completed	Intervention	2015-06-10	<NULL>	<NULL>	2141	Effect of administration of probiotics on inflammatory markers in overweight women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2hz3tg	<NULL>	body mass index between 25 and 39.9 kg/m2; aged between 20 and 64 years; who receive outpatient care in general nutrition and nutrition in endocrinology hospital of the University Federal of Goiás	Do not perform all evaluations; Participate in a program of food restriction; Body mass index less than 25 kg/m2 or 40 kg/m2; Patients with immune diseases or immunosuppressive drugs; Patients with liver or kidney disease; chronic alcoholics; In using nutritional supplements;  Pregnant women; In insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5kj6n2	Development and Application of Educational Multimedia in oral health orientation in patients with use of teeth apparatus	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2142	Development and Application of Educational Multimedia in oral health orientation in orthodontic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Federal de Sergipe	Atlântico Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-5kj6n2	<NULL>	Patients without orthodontic appliance or fixtures installed; above 18 years; access to a smartphone; without history of orthodontic treatment.	Patients with orthodontic appliance or fixed fittings installed; children under 18 years of age; without access to a smartphone; with a history of orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-77h2pr	Effect of video games on rehabilitation in patients in the burn therapy unit in sergipe	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2143	Effects of virtual reality in patients of the therapy of the therapy unit of Sergipe burns.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-77h2pr	<NULL>	Patients with burns 2nd and 3rd grades in the thorax and upper limbs, which are hemodynamically stable, suitable for rehabilitation in terms of cognitive ability to follow simple commands, have normal or corrected vision and hearing with the use of orthoses.	Patients with sequelae of central and peripheral burns, encephalopathies, fractures, muscular distension, psychiatric disorder, use of artificial airway and mechanical ventilatory support.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-4739sb	The Effect of Horse-Assisted Therapy on Performance in Children with Cerebral Palsy: Case Study	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2144	The effect of equine therapy on functional performance in children with Cerebral Palsy: a case study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade Dinâmica do Vale do Piranga	Centro de Equoterapia Animal Amigo	https://ensaiosclinicos.gov.br/rg/RBR-4739sb	<NULL>	Child of 12 years; diagnosis of Cerebral Palsy	Equinofobia; hip dislocation; deformity of the vertebral column	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5by938	Pregnant women with diabetes and oral health	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2145	Workers Health: Pregnant women with diabetes and oral health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5by938	<NULL>	Pregnant women at any stage of gestation with diabetes mellitus	Pregnant women at any stage of pregnancy who do not have Diabetes Mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-878xgs	The importance of telephone counseling for the preparation of the Intestine Exam	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2146	Impact of nurse orientation by telephone on the preparation of the Colonoscopy Examination	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-09	Departamento de Enfermagem da Faculdade de Medicina de Botucatu	UNESP _ Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-878xgs	<NULL>	"Inclusion: Patients attending the nursing consultation for orientation to the examination, 
Patients older than 18 years"	Patients who do not have a telephone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-7prdf2	Study on the body image of Brazilian adolescents	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2147	Body Image among Brazilian adolescents: diagnosis and intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de Juiz de Fora	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais - Campus Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-7prdf2	<NULL>	To be included in this study, the adolescent/youth should be enrolled in one of the integrated technical courses or undergraduate degree of the campuses of Barbacena, Rio Pomba and Juiz de Fora from IF Sudeste MG, have no mental or eating disorder diagnosed and wish to participate voluntarily in the research.	Students whose parents do not sign the Consent Term will be excluded, those who have a mental or eating disorder diagnosed or do not wish to participate in this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-4m4pkx	Performance of people with physical disabilities in virtual reality use	Recruitment completed	Intervention	2018-08-24	<NULL>	<NULL>	2148	Analysis of motor performance of people with stroke through virtual reality	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-13	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4m4pkx	<NULL>	Inclusion criteria: diagnosed for stroke for more than one year age greater than 18 years; have the cognitive ability to understand and respond to the proposed scales with minimum score values 13, evaluated by the minimal; absence of surgeries in the assessed upper limb	As exclusion criterion, no patient was admitted with the presence of associated diseases that could interfere with the protocol, such as Parkinson&apos;s; patients with severe aphasia and visual and / or auditory disorders that impede the comprehension and response of the items of the evaluation scales	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-3zs6g9	Effects of equine therapy on postural balance, gait, performance and functional mobility and quality of life in healthy people and people with disability	Not yet recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2149	Evaluation of the stimuli produced by the intervention with equine therapy on the kinetic and kinematic variables of healthy and pathological subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-12	Universidade de Brasilia	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3zs6g9	<NULL>	"The volunteers should be have more than 6 months after stroke; have a level 3 or higher in the
Functional Ambulation Category (FAC) -
walk independently or with the help of a third party; have a score higher than
24 in the Mental State Mini Exam or appropriate score in case of
illiterates.
For subjects with multiple sclerosis: The inclusion criteria adopted were: women aged between 20 and 60 years; confirmed medical diagnosis of multiple sclerosis in its most frequent form (referent-recurrent); rated between 1.0 and 3.0 by the EDSS scale."	"Diagnosis of Bilateral Stroke with double hemiparesis; uncorrected visual or auditory deficiency;
comorbidities that may interfere with the equotherapeutic treatment, for example,
psychiatric problems, cognitive deficit with apraxia, aphasia with inability to
follow simple commands; patients with active cardiovascular diseases;
uncontrolled diabetes and weight greater than 97 kg; have practiced activity
in the last 6 months;
For subjects with multiple sclerosis:The exclusion criteria were: having had an outbreak in the last 30 days; presence of infectious and neoplastic diseases; have musculoskeletal disease in the lower limbs that compromises the performance of the tests; associated neurological diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2jnmv8	Evaluation of an adhesive for local anesthesia without use of needles in dental treatments	Recruitment completed	Intervention	2018-08-27	<NULL>	<NULL>	2150	Evaluation of a polymer device for local anesthesia: in vivo test in adult humans in clinical dental procedures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-22	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2jnmv8	<NULL>	Individuals with good general systemic health; both genders; age between 18 and 90 years; need for dental treatment of medium complexity; who need local anesthesia in routine clinical treatment.	Pregnant women; alcoholics; smokers; users of illicit and / or lawful drugs operating in the central nervous system (CNS); individuals with allergies to medications; devitalized teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5zjsrk	Oral hygiene of intubated patients and mechanical ventilation: analysis of the cost and effectiveness of discarding and reuse of materials used in plaque control	Recruitment completed	Intervention	2018-08-27	<NULL>	<NULL>	2151	Oral hygiene of patients undergoing invasive mechanical ventilation: cost-effectiveness analysis between discarding and reuse of dental brushes and lingual cleansers after disinfection in oral biofilm control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5zjsrk	<NULL>	age greater than 18 years; being intubated orally&gt; 12 hours and intubated under mechanical ventilation	difficulty in opening the buccal cavity, periodontal tumor, allergic to oral chlorhexidine or topical gel	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2r4d3h	Evaluation of a Diabetes Education Program in the clinical evolution of patients with type 1 diabetes mellitus treated at two public services in Brazil	Data analysis completed	Intervention	2018-08-27	<NULL>	<NULL>	2152	Evaluation of the efficacy of a Structured Diabetes Education Program in the clinical evolution of patients with type 1 diabetes mellitus treated at two regional reference services in Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Instituto da Criança com Diabetes do Rio Grande do Sul - ICDRS	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-2r4d3h	<NULL>	Have diagnosis Type 1 Diabetes Mellitus; be from eight and 21 years old (incomplete); have less than five years of disease; be willing to participate in the educational sessions; sign the consent form (TCLE)	Non adhere to the consent form (TCLE); have visual, auditory deficiency,  active psychiatric illness or mental disability  that compromises understanding of the educational content; participating or having participated in another diabetes education program at the time of inclusion in the study; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5t8dbp	Effect of Physical Training in Treadmills on stiffness of arteries of Diabetic patients	Not yet recruiting	Intervention	2018-08-27	<NULL>	<NULL>	2153	Effect of Aerobic Training based on maximal fat oxidation on arterial stiffness in subjects diagnosed with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Programa de Pós-Graduação em Fisioterapia - PPGFt	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5t8dbp	<NULL>	Individuals diagnosed with type 2 diabetes of both sexes; from 40 to 60 years of age; who do not exercise vigorously at maximal and frequency greater than or equal to three times a week and who agree to participate in the study and sign the term of free and informed consent.	Individuals with a history of clinically proven cardiopathy or examination; uncontrolled arterial hypertension; musculoskeletal or respiratory disorders; cognitive disturbances that prevent the understanding of the experimental procedure; pregnant women; smokers; alcoholics or users of non-licit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2w97k4	Evaluations of the effect of smoke in the periodontal surgery technique using a microscope  for treatment of root exposure caused by gingival recession	Data analysis completed	Intervention	2018-08-28	<NULL>	<NULL>	2154	Evaluations the periodontal microsurgery technique for treatment of gingival recession on smokers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Fundação de Amparo à Pesquisa do estado da Bahia (FAPESB)	https://ensaiosclinicos.gov.br/rg/RBR-2w97k4	<NULL>	"Patients smokers and nonsmokers with Miller Class I and II buccal gingival recessions equal ou greater  then 2.0 mm located in maxillary canines or premolars; probing depth (PD) smaller then 3 mm without probing bleeding; absence of cavities, restorations , pulp alterations and orthodontic appliances in the areas to be treated; good general health; absence of contraindications to the surgical procedure; did not use medications that could interfere with the health of periodontal tissue or healing.
Smokers should report a minimum consumption of 10 cigarettes per day for at least 5 years."	Smokers with daily consumption of tobacco less than 10 cigarettes per day for at least 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-846kgn	Evaluation of the durability of the effects of a knee joint mobilization in individuals with osteoarthritis	Data analysis completed	Intervention	2017-07-17	<NULL>	<NULL>	2155	Evaluation of the durability of the effects of Mulligan&apos;s mobilization with moviment (MWM) in secondary hypalgesia,functional and emotional aspects, in individuals with diagnosis of knee Osteoarthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-846kgn	<NULL>	Diagnosis of symptomatic knee osteoarthritis, mild or moderate, with radiological evidence for at least six months; Between the ages of 50 and 70; Falls within a pain range of three to seven on the Visual Analogue Scale (VAS).	Have other musculoskeletal changes; Chronic inflammatory diseases such as autoimmune diseases (rheumatoid arthritis, lupus and gout); diffuse pain in the body (fibromyalgia); neuromuscular changes such as Parkinson&apos;s disease; other mental illnesses that may make it difficult to understand and perform the procedures requested in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-6hxyft	Analysis of the whitening effect and sensitivity during dental whitening using the Violet Light: Clinical study	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2156	Analysis of bleaching and neurosensory efficacy of dental sensitivity during dental bleaching using Violet Light: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6hxyft	<NULL>	Vital and healthy upper teeth. Absence of dental caries. No visible defects of the enamel. Absence of orthodontic appliance. Good systemic conditions. Healthy oral soft tissues. Non smokers. Patients who have never performed bleaching treatment.	Conoid teeth. Direct and indirect restorations in the upper anterior region. Adverse reactions to peroxide. Use of opiates or drugs that influence the neurosensory response. Use of pacemaker. Presence of dental pigmentation (tetracycline, trauma, fluorosis and unknown etiology). Neurological diseases. Chronic or acute diseases. Dentinal exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-83xh37	Effects of Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2157	Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia: randomized, double-blind, placebo-controlled and crossover clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Campinas (UNICAMP)	Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-83xh37	<NULL>	Age between 18 and 80 years old. Clinical diagnosis of Hereditary Spastic Paraplegia. Ability to walk out of home. Assistive devices are permitted	Wheelchair bound patients. Additional neurological symptoms that may significantly impact gait such as ataxia, lower motor neuron disease, polyneuropathy, mental retardation or dementia. Fixed tendon contractures. Current botulinum toxin injection or in the last six months. Pregnants or breastfeeding. Refusal to consent form. Skin infection or inflammation at site of interest.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-75t8zp	Effects of Pilates Training on Muscle Activity during disturbance in females with chronic low back pain	Data analysis completed	Intervention	2018-08-30	<NULL>	<NULL>	2158	Effect of a pilates training program on postural control of women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-75t8zp	<NULL>	Participants who did not present: Vestibular problems ie Labirintite; Somatosensory deficiencies such as Diabetic Neuropathy; Neurological problems such as stroke, Parkinson&apos;s, Multiple Sclerosis; Any other type of impairment that could influence permanence in the orthostatic position; Had the consent of a physician to practice the Pilates classes alone; Sign the TCLE; Be between 25 and 55 years of age; Classify as physically inactive or insufficiently active.	People who participated in other physical activities; Women who did not attend Pilates classes regularly; Who became pregnant during the survey period; Have left the license for more than three months for any eventuality; Did not complete all the tests / evaluations of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-77kfj5	Evaluation of the interference in the immunity caused by anesthetics Sevoflurane versus Propofol in intraoperative obese patients (obesita): study protocol for a randomized clinical trial	Not yet recruiting	Intervention	2018-08-30	<NULL>	<NULL>	2159	Evaluation of the immunomodulatory response of Sevoflurane versus Propofol in the intraoperative of obese patients (obesita): study protocol for a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-11	Rede D&apos;Or Sao Luiz S.A.	Laboratório de Investigação Pulmonar da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-77kfj5	<NULL>	Age range 18 to 59 years; body mass index greater than or equal to 35 kilograms per square meter; signature of the free and informed consent form.	Patients with insulin; anti-inflammatory and / or immunosuppressive therapies; diagnosis of malignant disease; chronic kidney disease, with KDOQI greater than 3; chronic liver disease, with total serum protein less than 3 grams per deciliter and total bilirubin greater than 5 milligrams per deciliter; heart disease, with NYHA III or IV; obesity caused by endocrine disorder; patients with psychiatric illness that may interfere with the capacity for formal consent and compliance; persistent smoking associated with significant obstructive or restrictive lung disease, with vital capacity or forced expiratory volume in one second less than 50% of predicted value; alcohol dependence; pre-existing coagulation disorders; evident pulmonary or systemic infection, with clinically defined or increased C reactive protein above 5 milligrams per ml, leukocytosis greater than 10,000, or body temperature greater than 37 Celsius; presence of autoimmune diseases; participated in another randomized clinical trial in the last year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2c825y	Association of genetic differences in the inflammation of patients with traumatized teeth	Recruitment completed	Intervention	2018-08-31	<NULL>	<NULL>	2160	Association of host&apos;s gene polymorphisms that participate in the immune-inflammatory response of traumatized teeth	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2c825y	<NULL>	Patients of both genders. Teeth avulsed and replanted	Immunocompromised patients.  Patients taking continuous medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-3npbf8	Evaluation of biological markers (psychological and physiological) after therapy to reeducate thinking and behavior in university students with Major Depressive Disorder.	Recruiting	Intervention	2018-08-31	<NULL>	<NULL>	2161	Evaluation of psychophysiological biomarkers after Cognitive-Behavioral Therapy in university students with Major Depressive Disorder.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal do Rio Grande do Norte	Faculdade de Medicina de Ribeirão Preto - FMRP-USP, Universidade de São Paulo (USP).	https://ensaiosclinicos.gov.br/rg/RBR-3npbf8	<NULL>	"Healthy volunteer (control) - No diagnostic or history of psychiatric disorders; age from 18 to 35 years and be a student of UFRN.


TDM patient - presence of current depressive episode, with mild or moderate grade; age from 18 to 35 years and be a student of UFRN."	"Healthy volunteer - Current diagnosis of clinical disease based on anamnesis and/or laboratory tests; present suicidal risk; diagnosis of Bipolar disorder, types I or II; show specific phobic symptoms for injection-blood-injury; presence or history of psychotic symptoms, mania or hypomania, induced or not by antidepressants or substance use; abuse or dependence on alcohol and other drugs; pregnancy.

TDM patient - present severe levels of depression (according to the Hamilton Depression Rating Scale (HAM-D) and / or the Montgomery and Asberg Depression Rating Scale (MADRS)); use psychiatric or neurological medications or drugs with effects on cognition, mood, and neurovegetative functions; be in treatment by psychotherapy; show diagnostic for others mental disorder in addition to major depression; present phobic specific symptoms of injection-blood-injury; pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-2ts2kg	Use of oxygen in the skin to treat wounds	Recruitment completed	Intervention	2018-08-31	<NULL>	<NULL>	2162	&quot;Oxygen therapy topical in jets in the treatment of infected surgical wounds&quot;	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-03	Centro de estudos Augusto Leopoldo Ayrosa Galvão	Centro de estudos Augusto Leopoldo Ayrosa Galvão	https://ensaiosclinicos.gov.br/rg/RBR-2ts2kg	<NULL>	Adult patients with surgical wounds infected more than 30 days proven by laboratory examination	Patients with drainage holes and patients with chronic obstructive pulmonary disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4rj39m	Rheumatoid Arthritis patients groups	Not yet recruiting	Intervention	2018-08-31	<NULL>	<NULL>	2163	Educational groups for patients with Rheumatoid Arthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-31	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4rj39m	<NULL>	Rheumatoid Arthritis diagnosis; Management of Rheumatoid Arthritis in Rheumatology Department of Clinics Hospital of Federal University of Minas Gerais; Avaiability to attend reunions of the patient&apos;s groups; Giving informed consent (by signing the consent form).	Refusal to participate of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-3wmd9s	Eye gel surgery for correction of the retinal hole and retinal membrane with or without cataract removal	Recruitment completed	Intervention	2018-08-31	<NULL>	<NULL>	2164	Vitrectomy with or without phacoemulsification for treatment of Macular Hole and Epiretinal membrane	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Hospital das Clínicas de Ribeirão Preto	Hospital das Clínicas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3wmd9s	<NULL>	Patients with a diagnosis of idiopathic macular hole;epiretinal membrane with indication of vitrectomy surgery;Patients without cataract or with opacification of crystalline at most 2 + / 6 + cortical and 2 + / 6 + nuclear, without SCP opacity	another eye disease;Any previous ocular surgery, with the exception of intravitreal injections;Systemic disorders affecting the eye;Inability to report satisfactorily or inability to collaborate, preventing us from obtaining well-documented examinations; Crystalline opacity that interferes with the visualization of the vitreous chamber, that is, posterior subcapsular of any intensity and nuclear or cortical greater or equal to 3+.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-5xnjbc	Non-Invasive Brain Stimulation in the treatment of Pain due to brachial plexus injury	Recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2165	Transcranial Magnetic Stimulation Versus Transcranial Direct Current Stimulation in the Treatment of Neuropathic Pain due Braquial Plexus Injury: A Randomized Pilot Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Programa de Pós-graduação em Neurociência Cognitiva e Comportamento	Instituto de Neurologia e Neurocirurgia da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5xnjbc	<NULL>	"Age over 18 years
Score of 4 to 10 points in the Scale for Pain Evaluation
Persistent pain and refractory to clinical treatment for at least 6 months
Appropriate pharmacological treatment for pain for at least 1 month before the start of the study"	"Patients with other neurological or psychiatric disorders, including major ongoing depression
Previous history of substance abuse
Contraindications for rTMS and / or tDCS"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-738wng	Effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals	Recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2166	Evaluation of the acute effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals through functional parameters	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-738wng	<NULL>	Individuals over 18 years of age, both sexes, healthy	diagnosis of osteo-myocardial diseases; neurological disease that causes &quot;fear&quot; of the movements on the oscillating platform; clinical disease; at the discretion of the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4y4q7z	Training through kinesiotherapy and pilates to the pelvic floor	Not yet recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2167	Pelvic floor training in the elderly: A randomized controlled trial comparing treatment techniques through the pilates method and kinesiotherapy.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4y4q7z	<NULL>	Women aged 60 or over, living in Porto Alegre and who agree to participate in the study and who have signed the Free and Informed Consent Term.	women with disabling diseases that prevent the performance of pilates exercises that have undergone gynecological surgery will be excluded, in order to initiate any type of structured and planned physical activity, in addition to those provided for in this protocol and that present genital prolapse above the second the POP-Q classification (Pelvic Organ Prolapse Quantification System).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4m57pq	The impact of the use of beneficial bacteria and fibers on hunger, blood glucose and health	Recruitment completed	Intervention	2018-09-03	<NULL>	<NULL>	2168	The impact of the use of symbiotics on satiety, glycemia and metabolic endotoxemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4m57pq	<NULL>	The study population is composed of eutrophic women, aged between 20 and 50 years.	The exclusion criteria adopted for participation in this research will be: non-performance of all evaluations; participate in a food restriction program; Body Mass Index less than 18.5 kg / m2 and greater than 25 kg / m2; carriers of immune diseases, of hepatic or renal disease, hypo or hyperthyroidism, inflammatory and / or infectious diseases; lactose intolerant, in the use of anti-inflammatory drugs and / or antibiotics and / or immunosuppressants and / or nutritional supplements and / or insulin; chronic alcoholics; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-53f8nh	Use of auxiliary Triamcinolone acetonide in glaucoma surgery: a clinical trial	Recruitment completed	Intervention	2018-09-04	<NULL>	<NULL>	2169	Application of subtenon Triamcinolone acetonide in primary Trabeculectomies in non-inflammatory Glaucomas: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53f8nh	<NULL>	Both genders; diagnosis of clinically uncontrolled non-inflammatory glaucomas with indication of trabeculectomy.	Diagnosis of inflammatory glaucomas (neovascular and uveitic glaucoma); Diagnosis of glaucomas with associated clinically relevant cataracts, and indication of combined surgery; Previous intraocular surgery, except for uncomplicated phacoemulsification or laser surgery performed more than 6 months prior to glaucoma surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-3bz2h2	Preventive intervention of changes in Body Image, Eating Disorder and Body Dysmorphism of young adult men	Not yet recruiting	Intervention	2018-09-04	<NULL>	<NULL>	2170	Preventive intervention in Body Image Disturbances, Eating Disorder and Body Dysmorphia in young adults: a randomized controlled clinical trial in Brazilian men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de Juiz de Fora campus avançado Governador Valadares	Universidade Federal de Juiz de Fora campus avançado Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-3bz2h2	<NULL>	Students. Men. Male. Between 18 and 30 years. Any color, race or ethnicity. Be regurlamente enrolled in the Federal University of Juiz de Fora-UFJF campus Governador Valadares - MG. Opt to participate voluntarily in the study.	Possess mental disorder, food and / or dysmorphic body diagnosed. Do not respond to instruments in the follow-up period. Ask for the termination of your participation, by means of an express, free and informed expression. Expressly request not to use your data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4njb3p	Effect of therapeutic bath in pain, in sleep and vital sign in babies influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2171	Effect of therapeutic bath in pain and physiological variables of infant influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-18	UCPEL - Universidade Católica de Pelotas	UCPEL - Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4njb3p	<NULL>	Neonates and infants hospitalized at the Neonatal Semi-Intensive Therapy Unit; with a life time of at least 72 hours, 1,250 grams; up to 6 months of age; which are parents or guardians agree to participate in the study.	clinically unstable preterm infants; contraindications to the immersion bath; new borns weighing less than 1,250 kg; infants who present temperature changes; need for ventilatory support; infectious process; neurological problems; facial congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-5pn79s	Effectiveness of speech therapy for the elderly with vocal alterations	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2172	Effectiveness of a Speech-Language Therapy Program for Presbyphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-26	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5pn79s	<NULL>	Individuals of both sexes, with 60 years of age or older, diagnosed with presbylarynx, with no previous history of vocal fold lesions or who have undergone laryngeal fioricrosurgery and / or who have a previous diagnosis of pneumopathy, heart disease or neurological disease, or other laryngeal changes associated with presbylarynx.	Individuals who have undergone previous speech therapy, do not have adherence to the proposed speech-language therapy; smokers, singers, who have cognitive and neurological alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-3qpr2n	Physiotherapy  treatment of vaginal stenosis and sexual dysfunction after brachytherapy	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2173	Impact of physiotherapy on quality of life and sexual function of women after locally advanced cervical cancer brachytherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Natalia Carion Haddad	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-3qpr2n	<NULL>	Female patients; aged between 18 and 65 years; in treatment for locally advanced cervical cancer (according to FIGO staging); who will undergo brachytherapy; and those who agreed to participate in the study	Patients with cognitive deficits, with distante metastases, with collagen diseases, pregnant women,  relapsing disease, residual disease reported in writing after the end of brachytherapy, submitted to a previous hysterectomy (partial or total), active condition of Venous Deep Thrombosis, cardiopulmonary disorders that limit ADLs, pacemaker patients, acute urogenital infection, genital prolapse, inability to stand up, phlebitis, embolism, advanced osteoporosis, epileptics, and those that lack any of the assessment steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-7w4szm	Analysis of the situation of Diabetes in the state of Espírito Santo and the actions developed by health professionals	Recruiting	Observational	2018-09-05	<NULL>	<NULL>	2174	Spatial analysis of Diabetes and evaluation of health practices developed: a contribution to health planning and decision making in the state of Espírito Santo, Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7w4szm	<NULL>	Professionals working in the units for at least six months; users attended by professionals selected for at least six months; users with complications resulting from diabetes	Recent users in the unit; unregistered users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-8cnkwq	Evaluation of the effect of the school&apos;s prevention program to the use of drugs #Tamojunto2.0, version 2018	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2175	Effectiveness evaluation of the school&apos;s prevention program to the use of drugs of the Ministry of Health: # Tamojunto2.0, version 2018	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-25	Universidade Federal de São Paulo - UNIFESP	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8cnkwq	<NULL>	Being a student enrolled in grade 8 (old 7th grade) of one of the public schools randomly selected from the list of INEP, and consent to respond to the pre and post-test questionnaire.	Questionnaires without adequate codes; Students with cognitive impairment; Refusal in completing the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-7zccgr	Effects of complementary therapies associated with Cardiac Rehabilitation in patients with Chronic Heart Failure	Not yet recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2176	Effects of Noninvasive Ventilation and Inspiratory Muscle Training associated with Cardiac Rehabilitation in the kinetics of oxygen consumption in patients with Chronic Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7zccgr	<NULL>	The patients present a diagnosis of stable chronic Heart failure who are undergoing medical follow-up with a cardiologist and present stable disease suggested by the absence of any change in medication and without previous diagnosis of moderate or severe chronic obstructive pulmonary disease, exercise-induced asthma and previous hospitalization history last 3 months and anginal events in the three months before the study, with left ventricular systolic dysfunction with LVEF &lt;40% and New York Heart Association (NYHA) classification in classes II and III.	Patients with musculoskeletal diseases or any other situation that makes it impossible to perform aerobic or resisted exercises. To present worsening of signs and symptoms of HF after starting the proposed rehabilitation program. Present paradoxical breathing or persistent use of accessory breathing muscles or oxygen desaturation during the exercise program. Body mass index (BMI) &lt;35 kg / m. Any individual with severe, significant arrhythmias or unable to perform the exercise protocol associated with Non- invasive ventilation (NIV) or Respiratory Muscle Training (RMT) will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-26gmm3	Hidden Oclusal cavities in primary molars: use fluoride varnish, seal or restore.	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2177	Hidden Oclusal cavities in deciduous molares without obvious cavities: control, seal or restore	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-04	Universidade de Brasilia	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-26gmm3	<NULL>	We will select, through clinical and radiographic examination; children between 5 and 8 years of age who present primary molars with caries lesions CAST 4,;totalizing 75 teeth.	Molars with carious lesions that are radiographically located in the inner half of dentin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7b8f2c	Effects of physical exercise programs performed at outdoor fitness gym in hypertensive individuals	Recruitment completed	Intervention	2018-09-05	<NULL>	<NULL>	2178	"Effects of a Physical Exercise Program and
Guidance of Healthy Habits in Hypertensive Patients"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Metodista de Piracicaba - UNIMEP	Universidade Federal de Mato Grosso do Sul (UFMS) - Campus Pantanal	https://ensaiosclinicos.gov.br/rg/RBR-7b8f2c	<NULL>	Inclusion criteria were considered: both genders; age between 40 and 70 years; be hypertensive, according to the VII Arterial Hypertension Guideline (SBC, 2016); have clinical stability, as assessed by the cardiologist and / or clinician and medical certificate for participation in the study.	The exclusion criteria adopted were: to have diabetes and heart diseases; chronic obstructive pulmonary disease and asthma; obesity grade III; musculoskeletal and / or neuromuscular changes, which make it impossible to perform the tests and physical training; some other clinical condition diagnosed after the mandatory exams for inclusion in the program; participation in physical training programs, at the time of screening, in the last six months, and during the study; and absence in three consecutive classes in the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3j7xk2	Relationship of visual alteration with posture and its influence on body pain	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2179	Relationship of astigmatism with posture and its influence on body pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Faculdade Alfredo Nasser	Faculdade Alfredo Nasser	https://ensaiosclinicos.gov.br/rg/RBR-3j7xk2	<NULL>	Aged between 18 and 59 years; medical diagnosis of astigmatism.	Individuals with musculoskeletal changes that may influence orientation and posture control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2mk2fn	White spot lesion treatment	Recruiting	Intervention	2018-09-06	<NULL>	<NULL>	2180	Light-­induced fluorescence images as evaluation of white spot lesion treatment in orthodontic patient	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Faculdade de Odontolgia de Ribeirão Preto da USP	Faculdade de Odontolgia de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-2mk2fn	<NULL>	The following inclusion criteria will be adopted: absence of enamel hypoplasia or tetracycline pigmentation, not having used antibiotics in the 3 months prior to the study; not being on systemic medication, have not undergone periodontal treatment within 3 months prior to the start of the study, not being smokers, not be carriers of systemic disorders that could interfere with the periodontal condition, prior to the installation of the appliance, craniofacial anomalies.	Syndromic patients, deciduous dentition, patients with prosthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4kkq8c	Gel for the treatment of herpes lip lesions	Recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2181	Evaluation of precursory gel of film containing on-site anesthetic for treatment of the herpes simplex: randomized, double-blind and controlled clinical study.	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-03-10	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4kkq8c	<NULL>	Legal or minor adult volunteers with accompanying legal guardians; both genders; without current treatment regimen against herpes.	Individuals in use or who used systemic-specific antiviral medication in the 15 days preceding the study;pregnant women;patients with heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-9p9drm	The efficacy of chewing gum for pain control during orthodontic treatment	Data analysis completed	Intervention	2018-09-10	<NULL>	<NULL>	2182	The efficacy of chewing gum for pain control during orthodontic treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9p9drm	<NULL>	Patientes with aged 13 until 40 years; complete permanent dentition; moderate crowding.	Patients with elastic separators, phenylalanine allergy, TMJ symptoms, chronic use of analgesics and those that would need to use medicine for any other reason were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6sq4c9	MDMA-assisted psychotherapy in the treatment of trauma	Recruitment completed	Intervention	2017-12-13	<NULL>	<NULL>	2183	3,4-Methylenedioxymethamphetamine (MDMA) assisted psychotherapy in the treatment of Post-Traumatic Stress Disorder	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2018-02-01	Instituto Plantando Consciência	Multidisciplinary Association for Psychedelic Studies (MAPS)	https://ensaiosclinicos.gov.br/rg/RBR-6sq4c9	<NULL>	Fulfill PTSD criteria according to DSM IV, lasting at least six months; CAPS score equal or superior to 60 points, indicating moderate to severe symptoms; At least 18 years old completed; Previous attempts to relief PTSD symptoms with other therapies, without success; If on current psychotherapeutic treatment in the moment of study inclusion, participants can keep this psychotherapy. Participants in this situation must sign a permission for researchers to directly communicate with the psychotherapist outside the study team. Participants can not change therapist, increase frequency of therapy or start new therapy until the final evaluation which will happen two months after the last MDMA session. Participants who live at a distance which requires more than two hours driving to the study site must have a local therapist in their home town who can provide support in case of need. Participants are willing to abdicate the use of any psychiatric medications during the period of the study, exception made to gabapentin prescribed for pain management. In case of use of psychostimulants for ADHD in the study screening, they can keep the same dose and regime provided medication is tapered off for 5.5 half-life before each MDMA session and must not restart this medication until 10 days have elapsed from each MDMA session. Any psychoactive drug, including psychostimulants, will be progressively discontinued in order to avoid abstinence symptoms. Any medication will only be discontinued after consultation with the physician who prescribed it. Agree to, one week before each MDMA session, to abdicate from: Use of any herb supplement (except in case of prior approval by research staff). Use of any non-prescription medication (exception made to non-sterodial anti-inflammatory drugs or paracetamol, except in case of prior approval by research staff). Use of any prescribed drug (exception made to contraceptive pills, tyroid hormones or other medications with previous approval of research staff). Agree to not ingest alcoholic beverages after 24:00 in the night previous to each MDMA session; Abdicate the use of any psychoactive drug, exception made to caffeine and nicotine, for 24 hours before each MDMA session; Agree to not use caffeine or nicotine for, respectively, two and six hours after MDMA administration; Agree to not drive or operate machinery for 24 hours after MDMA administration in each therapeutic session; Are willing to be contacted by phone in order for all the research monitorings to be conducted; Must present negative pregnancy test if fertile and agree to use effective contraceptive methods during the whole study, exception made to the long term follow up; Must present a contact person (family, husband or wife, close friend or another carer) who is willing to be contacted by the researchers in case the participant present signs that want to commit suicide; Must agree to inform the researchers before 48 hours after any medical condition appears; Are fluent in Portuguese and have basic education level (&quot;Ensino Médio&quot;) completed; Agree to have all preparatory, therapeutic and integration sessions recorded in audio and video. Agree to not take part in any other clinical trial while this one lasts.	Pregnant or lactating women, or women who can potentially get pregnant during the study and are not using efficacious contraceptive methods; Have history or are currently diagnosed with type 1 bipolar disorder or dissociative affective disorder; Have signs or history of coronary arterial disease, peripheral vascular disease, hepatic disease with hepatic enzyme alterations or any other medical condition that the research staff, including the Responsible Physician, concludes to increase risks in the administration of MDMA. Hypertension according to the Brazilian Cardiology Society (Nobre et al, 2010). Hepatic disease, with the exception of asymptomatic hepatitis C patients who have undergone successful treatment before inclusion in the study; Have 48 kg or less; History of hyponatremia or hyperthermia; Have serious risk of suicide, according to psychiatric interview, responses to C-SSRS and with the clinical judgement of researchers, or according to researchers clinical evaluation are under serious risk of hospitalization during the study; Present serious risk of harming others, according to psychiatric interview and screening and with contact with previous psychiatrist who has previously treated the patient; Has used &quot;ecstasy&quot; (street drug presented as containing MDMA) more than 10 times in the last ten years or at least once in the six months before the first therapeutic session; Require therapy with psychiatric drugs during this trial, exception to drugs mentioned in item 7 of the section 4.1.1, &quot;Inclusion Criteria&quot; Are classified, according to DSM IV criteria, as individuals with drug abuse or dependence in the last 60 days, exception made to caffeine and nicotine; Are not apt to adequately read and sign an informed consent; Have any history or problem associated with drug and alcohol abuse that may, in the opinion of the researchers or the Responsible Physician, interfere with participation in this study according to its protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6t4j85	An evaluation of a medicinal herb as a treatment for Parkinson’s disease	Not yet recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2184	A phase 2, double-blind, randomized, controlled trial of the safety and efficacy of Banisteriopsis caapi versus placebo in patients with Parkinson´s disease	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-09-02	Hospital Universitário Clementino Fraga Filho - UFRJ	Hospital Universitário Clementino Fraga Filho - UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-6t4j85	<NULL>	40 l-dopa treated patients (both genders) with Parkinson’s disease fulfilling the Queen Square Brain Bank Criteria with mild to moderate motor fluctuations will be recruited.	Demented patients with the Mini Mental Status Examination Score, women of childbearing age and those receiving monoamine oxidase inhibitors or amantidine were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3n52h4	Movement analysis of individuals with knee arthosis submitted to treatment with intra-articular viscosupplementation	Recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2185	Biokinetic analysis of individuals with knee osteoarthritis submitted to treatment with intra-articular viscosupplementation	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-10-01	Instituto Brasil de Tecnologias da Saúde	Hospital de Força Aérea do Galeão	https://ensaiosclinicos.gov.br/rg/RBR-3n52h4	<NULL>	Patients registered in the surgery waiting queue; older than 60 yo; able to walk ten meters independently; without external aid.	valgus or varus deformity higher than fifteen degrees; neurological impairment; indication for bilateral TKA; OA related to periarticular fracture or of septic origin; who have functional limitations in ankle or ipsilateral hip as a result of prior trauma; who do not agree with the consent terms to the research; who refuse to receive the articular infiltrations or perform biomechanical tests; who have no autonomy to raise, sit and/or walk without assistance from other people; illiterate individuals or those who are unable to answer independently the IKDC and LEFS questionnaires; who have used in the last six months or at any time during the study period corticosteroid drugs or surgery in the affected limb.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-33tdwy	Sexual counseling for women who withdraw the breast	Data analysis completed	Intervention	2017-06-19	<NULL>	<NULL>	2186	Intervention of Sexual Counselling for mastectomized: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-11	Maternidade Escola Assis Chateaubriand	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-33tdwy	<NULL>	"Mastectomized women; To have at least six months of surgery; To be over 18 years of age;
To have started sexual activity"	Mastectomized women taking antidepressants; Mastectomized women with disabling diseases that prevent the sexual act.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7rwmvj	Influence of mechanical ventilation and heart rate on obstruction to cardiac blood flow in patients with hypertrophic obstructive cardiomyopathy	Not yet recruiting	Intervention	2018-09-11	<NULL>	<NULL>	2187	Influence of PEEP and heart rate on the maximum systolic gradient of the left ventricular outflow tract of patients with hypertrophic obstructive cardiomyopathy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-04	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-7rwmvj	<NULL>	All adult patients (&gt; 18 years) diagnosed with hypertrophic obstructive cardiomyopathy, in follow-up at the cardiology outpatient clinics of the Dante Pazzanese Institute of Cardiology, with indication of septal reduction therapy, submitted to endocardial radiofrequency ablation of septal hypertrophy, who agree to participate in the study.	Patients who did not agree to participate in the study; Age under 18 years; Chronic obstructive pulmonary disease; Previous surgical myomectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-8s8c8c	Effectiveness of using networks on reducing pain and improving sleep in premature	Recruitment completed	Intervention	2017-11-27	<NULL>	<NULL>	2188	Effectiveness Positioning Hammock on reducing pain and improving the state of sleep and wakefulness in newborn preterm infants: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8s8c8c	<NULL>	Newborns with a gestational age between twelve thirty-seven p.m. weeks; use of non- invasive mechanical ventilation; nasal oxygen catheter; without supplemental oxygen; clinically stable; be admitted to neonatal intensive care unit	Newborns with a gestational age of 37 weeks; clinically unstable; need for invasive mechanical ventilation; neurological or cardiac involvement; bad facial birth defects.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6zfy89	Quality management: control of unplanned extubation in children admitted to a pediatric intensive care unit	Recruiting	Observational	2018-09-12	<NULL>	<NULL>	2189	Quality management: control of unplanned extubation of pediatric patients in a pediatric intensive care unit	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital de Clínicas da Universidade Federal do Praná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-6zfy89	<NULL>	Patients of both genders; with ages ranging from 28 days to 14 years; intubated and mechanically ventilated; admitted to the Pediatric ICU; with an informed consent form signed by a parent or guardian.	Tracheostomized patients; pacients  with noninvasive mechanical ventilation; did not sign the Informed Consent Term pacients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3vybj7	Classification of intensive care center patients according to the workload for Physiotherapy	Recruiting	Observational	2018-09-12	<NULL>	<NULL>	2190	Classification of intensive care unit patients according to the workload for Physiotherapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-22	Hospital Universitário da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vybj7	<NULL>	Physiotherapy session of patients admitted to the adult intensive care unit of the University Hospital of University of São Paulo	Interrupted physiotherapy session; compromised data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2brcxq	Association of Infection with Parenteral Nutrition	Data analysis completed	Observational	2018-09-12	<NULL>	<NULL>	2191	Infection associated with Parenteral Nutrition: Retrospective cohort study in tertiary hospital and systematic review with meta-analysis on the association of Parenteral Nutrition with infections and mortality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2brcxq	<NULL>	Adult patients submitted to NP admitted to the Hospital de Clínicas de Porto Alegre (HCPA).	"Central peripheral insertion catheter.
Central catheter for long stay.
Sustained parenteral nutrition less than 72 h after onset."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4yz96t	Core and Mckenzie Exercises in Non-Specific Chronic Low Back Pain in Hospital Hygiene Workers	Recruitment completed	Intervention	2018-09-12	<NULL>	<NULL>	2192	Comparative Effects of Core and Mckenzie Stabilization Exercises on Non-specific Chronic Low Back Pain in Hospital Workers of the Santa Luzia Hospital of Capão Da Canoa,	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	AESC - Associação Educadora São Carlos	AESC - Associação Educadora São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4yz96t	<NULL>	Professionals in the sanitation service sector; both sexes; with symptomatology of nonspecific lumbar pain superior to grade three in the Visual Analogue Pain Scale (VAS); age between 18 and 60 years; ability to perform exercises.	History of current neurological, infectious and systemic diseases; Lumbar pain of root characteristic; pregnancy or suspected pregnancy; any co-operative dysfunction or inability to respond to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-8mpyq4	Effects of interval running and cranberry supplementation on the immune system	Not yet recruiting	Intervention	2018-09-12	<NULL>	<NULL>	2193	Effects of interval training and cranberry supplementation in immunomodulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8mpyq4	<NULL>	Present VO2max classification between 35 and 55 ml.kg-1.min-1; be engaged in running training for at least three times a week; has no musculoskeletal disorder, autoimmune, cardiac, pulmonary or hypersensitivity disease; not use anti-inflammatory drugs or food supplements, including substances with antioxidant function, at least 30 days before the study period.	Do not meet 100% of the number of sprints in one or more high intensity interval training (HIIT) protocols; do not carry out any of the pre or post evaluation of HIIT; if they are absent in one of the six sessions of HIIT; present any injury or motor impairment to perform HIIT; present any infection of the upper respiratory tract during the experiment; antibiotic use within six months prior to study; regularly consume any dietary supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the doses of cranberry proposed for the supplementation stage; present known allergy or intolerance to cranberry products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-5jv4qs	Effects of Magnesium on Endothelium in Hypertensive	Recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2194	Effects of Magnesium on Endothelial Function in Hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-5jv4qs	<NULL>	"Outpatient patients between the ages of 40 and 65 years.
Both genders, with postmenopausal women.
Hypertensive patients with systolic blood pressure greater than or equal to 140 mmHg and / or diastolic blood pressure greater than or equal to 90 mmHg.
In pharmacological treatment, with stable use of at least two antihypertensive classes in the last four weeks.
Patient with body mass index less than or equal to 35 kg / m2.
Patients with habitual food consumption maintained for at least four weeks.
Signature of the Informed Consent Term (SICT)."	"Smoking.
Diabetes Mellitus.
Hormone replacement therapy.
Hypertension with blood pressure greater than 160/100 mmHg.
Use of beta-blocker or statin.
Evidence of secondary hypertension.
Changes in thyroid function, chronic renal and liver diseases.
Clinically evident coronary disease with prior history of acute myocardial infarction and / or myocardial revascularization, with clinical signs of heart failure, symptomatic cardiac arrhythmia, or clinically significant valve disease, prior cerebrovascular accident.
Use of nutritional supplements (vitamins, minerals) for up to seven days before the start of the study.
Patients presenting with any serious illness and any condition, illness or therapy that, in the opinion of the investigator, may impair the results, interfere with the study objectives or jeopardize patient safety."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2z96w6	Effects of Multicomponent Exercise on Cognition in the elderly	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2195	Multicomponent exercise program on cognition, structure and brain function in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes- HUOL/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2z96w6	<NULL>	Age between 60 and 75 years, with medical clearance to six months before clinical evaluation.	Body mass index equal or greater to 35; use of medication that suppresses neuroendocrine system responses; not reach the minimum of 23 points in the mini mental state exam; musculoskeletal limitations that limits the practice of physical activity; report at least one yes on response in PARQ; participate in regular physical exercise programs and dietary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4sw7h7	Comparison of fat grafting techniques for reconstruction of head deformities after surgical treatment of epilepsy	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2196	A comparative randomized clinical trial of different autologous free fat grafting techniques for reconstruction of temporal contour defects after surgical treatment of epilepsy: structural fat grafting versus micro autologous fat transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Faculdade de Ciências Médicas, UNICAMP	Hospital SOBRAPAR	https://ensaiosclinicos.gov.br/rg/RBR-4sw7h7	<NULL>	Patients over 18 years of age; both genders; ASA (American Society of Anesthesiology) 1 or 2; submitted to standardized craniotomy for the treatment of temporal lobe epilepsy for at least 12 months; with temporal contour deformity; integrity of the craniofacial skeleton	Patients undergoing additional cranial surgery; pregnancy; active infection in the temporal region; previous radiotherapy; contraindications for magnetic resonance imaging such as the presence of cardiac pacing, intracranial metal clips and / or severe claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2sdy28	Probiotics use for gum disease treatment	Recruiting	Intervention	2018-09-14	<NULL>	<NULL>	2197	Probiotics use in periodontal diseases treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-2sdy28	<NULL>	Volunteers must present Periodontitis; presence of probing pocket depth &gt; 3 mm in association with clinical attachment loss &gt; 3 mm in at least 2 sites of 2 non-adjacent teeth; They must also present more than 20 teeth; age between 30 to 70 years old.	Cigarete smokers; history of previous periodontal treatment; antibiotics use within the past 6 months; pregnancy; presence of acute or necrotizing lesions; history of diabetes; rheumatic fever; neurological deficiencies; immunological diseases; use of medications that affect periodontal tissues such as phenytoin, cyclosporine, nifedipine and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-3jjbs2	Effects of two placements on the behavior of preterm infants.	Recruitment completed	Intervention	2018-09-14	<NULL>	<NULL>	2198	Effects of positioning on dorsal and right lateral decubitus on behavioral and physiological indicators of preterm newborns.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-14	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jjbs2	<NULL>	"Pre-term with post-conceptual age on the day of intervention between 32 and 36 weeks and 6 days;
Of both sexes;
Postnatal age&gt; 24 hours;
Clinically stable (free of intravenous access, in ambient air and oral feeding, by nasogastric or orogastric tube;
In the case of twins, only one was chosen by lot."	"They presented neurological impairment (hydrocephalus, microcephaly, periventricular hemorrhage grades III and IV and brachial plexus lesion;
With congenital malformation (myelomeningocele, encephalocele, agenesias and focomelias, among others);
With suspicion of some kind of genetic alteration;
With sensorial alterations (visual and auditory);
With orthopedic alterations;
With viral, bacterial or congenital infections;
With an Apgar score equal to or less than 4, at 5 minutes, suggestive of choking;
Or whose mothers abused toxic substances during pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5hdw4d	Observation by ultrasound examination of variation of a belly vein during breathing in pediatric patients	Recruiting	Observational	2018-09-14	<NULL>	<NULL>	2199	Ultrasonographic evaluation of respiratory variation of the inferior vena cava in pediatric patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-5hdw4d	<NULL>	Children between 28 days and 14 years; admitted to the Unicamp Hospital das Clínicas; both sexes	Psychomotor agitation; respiratory distress; lesions or bandages on the abdominal region that make ultrasound examination impossible will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8s2nbf	Effect of the nintendo wii sport video game on rehabilitation of the arms of patients with post polio syndrome: Application research, security and acceptance of the game	Recruiting	Intervention	2018-09-15	<NULL>	<NULL>	2200	Effects of the nintendo wii Sports interactive video game on the motor function of upper limbs of individuals with post polio syndrome: randomized clinical trial of applicability, safety, acceptability	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8s2nbf	<NULL>	Patients diagnosed with SPP established by the consensus of Healsted &amp; Rossi (1985), patients who are not performing rehabilitation and or physical exercise during the application of the treatment protocol, patients with muscle strength greater than or equal 3 on shoulders and elbows	Patients unable to commit to the established protocol of 14 virtual reality therapy sessions, patients presenting shoulder anterior and or inferior subluxation clinically assessed by palpation greater than or equal to 2 fingers,patients with deformities in the upper limbs that make it impossible to train with the videogame	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5cgp6h	Effect of aerobic training combined with strength training with elastic tube on functional capacity, blood pressure and muscular strength in hypertensive patients	Recruitment completed	Intervention	2018-09-15	<NULL>	<NULL>	2201	Functional, hemodynamic and neuromuscular modifications in hypertensive subjects submitted to concurrent training and resistance training with elastic tube	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Santa Catarina	Programa de Pós-graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-5cgp6h	<NULL>	Inclusion criteria were: aged 50 years or older; controlled hypertension (&lt;140/90 mmHg); and medical release for physical exercise.	Subjects were excluded if they had participated in an aerobic and/or resistance training program in the previous 6 months; presented congestive heart failure; recent myocardial infarction; or joint or muscular limitations that compromised the movements in any of the exercises; did not meet the minimum of 85% of the total number of sessions planned.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-7v7tj5	Clinical Study on the effect of Bleaching Toothpastes	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	2202	Clinical Trial on the effectiveness of Bleaching Toothpastes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7v7tj5	<NULL>	Both genders; older than 18 years; presence of all natural anterior superior teeth; vitalized; naturally or physiologically darkened; without restorations involving the vestibular faces; with color darker or equal to A3 in the VITA scale of the tint guide; good oral health.	Patients with dental sensitivity; cervical lesions or fractures; smokers; pregnant women and infants; children and adolescents (under 18 years of age); previous history of cancerous lesions; caries and periodontal disease; prosthetics and / or previous restorations were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-97vpjx	Exercise during hemodialysis increases the removal of accumulated substances in the body	Recruitment completed	Intervention	2018-09-17	<NULL>	<NULL>	2203	Effects of physical training with partial restriction of blood flow on the efficiency of solubility by hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-16	Universidade Católica de Pelotas	Hospital Universitário São Francisco de Paula	https://ensaiosclinicos.gov.br/rg/RBR-97vpjx	<NULL>	Patients with chronic kidney disease treated for hemodialysis for more than three months; aged 18 or over; in the use of arteriovenous fistula, as access for hemodialysis; with clinical and hemodynamic stability, in the last month of dialysis therapy those who presented hypotensive episodes in less than 15% of the sessions; able to perform the protocol of proposed physical exercises; agreed to participate in the study	Patients with cardiac events in the last three months; with current diagnosis of infection or neoplasias; history of deep vein thrombosis in the last three months; with systolic blood pressure equal to or greater than 180 at rest; diastolic blood pressure equal to or greater than 105 at rest; resting heart rate above 120 beats per minute; cognitive alterations that make it impossible to understand the instructions of the exercises; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-3cqbw8	Effect of the shape of the posterior teeth on the satisfaction, quality of life and mastication of users of dentures	Recruiting	Intervention	2018-09-17	<NULL>	<NULL>	2204	Impact occlusal surfaces of posterior teeth in satisfaction, quality of life and masticatory efficiency of complete denture wearers bimaxillary	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-19	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3cqbw8	<NULL>	Volunteers should be in good general health; both genders; absence of intraoral lesions and alteration of the perioral musculature detected by palpation; as well as signing the Free and Informed Consent Form. Edentulous individuals less than 5 years old will not be included in the sample.	Those who have given up part of the survey; were in poor health; unable to attend to where the search is performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-25x5dn	Clinical reasoning skills for physical therapy students	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2205	Teaching clinical reasoning skills to physical therapy students: a controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-25x5dn	<NULL>	Physiotherapy course students enrolled in the new curriculum (which includes Integrated Practical Activities)	Students who are not enrolled in the new curriculum of physiotherapy course  which includes the discipline of Integrative Practical Activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8ptbqn	Study of andiroba oil in the healing of mucositis	Recruiting	Intervention	2018-09-17	<NULL>	<NULL>	2206	Evaluation of anti-inflammatory, cicatricial and toxicological activities of andiroba oil - carapa guianensis aubl (meliceae) on oral mucosite in patients submitted to quimioterpia	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-05-10	Universidade Federal do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-8ptbqn	<NULL>	Have clinical signs of induced oral mucositis; age equal to or greater than 18 years; complete consciousness; with no history of radiotherapy; not receiving systemic antibiotics and antifungal drugs nor mouthwash during the study	Being under 18 years of age, having undergone radiation therapy and taking antifungal drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-6by9h2	Influence of Aquatic Physiotherapy in the weight-bearing symmetry in the sit-to-stand transfer in hemiparetics after Stroke	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	2207	Influence of Functional Aquatic Physiotherapy in the weight-bearing symmetry in the sit-to-stand transfer in hemiparetics after Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-6by9h2	<NULL>	Clinical diagnosis of stroke (6 months – 5 years); aged between 18 and 65 years; ability to follow the instructions; sit-to-stand transfer independence – hold standing position for at least 3 seconds; without Physical Therapy at the moment.	Non-collaborative patients, those who had a new episode of stroke during the study and those who underwent orthopedic surgery less than 12 months and peripheral blocks less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-2rcm2g	Safety of different doses of the antimalarial drug Primaquine on Vivax Malaria Treatment in patients Deficient of the enzyme Glucose-6-phospate Dehydrogenase	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	2208	Safety and efficacy of different regimens of Primaquine on Vivax Malaria treatment in Glucose-6-phospate Dehydrogenase Deficient patients admitted at the Fundação De Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-07-18	Fundação de Medicina Tropical Heitor Vieira Dourado - FMTHVD	Fundação de Medicina Tropical Heitor Vieira Dourado - FMTHVD	https://ensaiosclinicos.gov.br/rg/RBR-2rcm2g	<NULL>	Inclusion criteria: Male and female patients; older than 6 months of age; diagnosed with uncomplicated vivax malaria; with enzymatic activity between 10-60%	Exclusion criteria: Patients with severe malaria; hemoglobin levels below 9 g/dL; pregnant or breastfeeding females; children less than 6 months old; with severe enzymatic deficiency (enzymatic activity less than 10%); nephropathy; hepatopathy; under the use of potentially hemolytic drugs specified in the project; under the use of antimalarial drugs until two weeks before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-9d6368	Laser treatment for thyroid benign tumors or follow-up	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2209	Percutaneous Laser ablation of benign thyroid nodules versus follow-up	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-05	Instituto de Radiologia do Hospital das Clínicas / Faculdade de Medicina da Universidade de São Paulo	Comissão de Ética para Análise de Projetos de Pesquisa - CAPPesq	https://ensaiosclinicos.gov.br/rg/RBR-9d6368	<NULL>	solid or solid-cystic with less than 20% of liquid benign thyroid nodule at ultrasound; nodule volume between 5-18 mL; serum levels of thyroid hormone and TSH in the normal range values; two negative cytological evaluations for malignancy in the last 6 months; no thyroid autoimmunity expressed by ultrasound or auto-antibody elevation over 100% of the standard level; calcitonin level under normal range values; anticoagulant treatment interrupted;	age under 18 years; extensive goiter; cystic nodule; hyper functioning nodule; elevated TSH levels; autoimmune therapy; active anticoagulant therapy; cytological specimens with suspected malignancy; pregnancy and breast-feeding; thyroiditis; asymptomatic nodule;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-4mz6w9	Effect of Inspiratory and Expiratory Training on autonomic modulation, exercise capacity and pulmonary capacity of Chronic Obstructive Pulmonary Disease patients	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2210	"Influence of Respiratory Muscle Training on hemodynamic changes,
pulmonary and autonomic diseases in patients with COPD"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4mz6w9	<NULL>	Volunteers with the diagnosis of Chronic Obstructive Pulmonary Disease; who had inspiratory muscle weakness (70% of predicted maximal inspiratory pressure); with absence of heart failure; with stable pharmacological treatment; and with no comorbidity such as type 2 diabetes mellitus and hypertension.	Volunteers who had acute myocardial infarction three months before inclusion in the study; unstable ventricular arrhythmia or in the last three months before onset; acute respiratory disease; rheumatic diseases; degenerative diseases; neurological sequelae and cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-77tjsw	The efect of Glutamine in the defense system of patients with HIV/AIDS	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2211	The influence of Glutamine in the Immunological system of patients with HIV/AIDS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-04	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-77tjsw	<NULL>	The study included patients considered to be adherent to the treatment, both men and women, between 18 and 50 years of age with positive serology for HIV/AIDS, enrolled in this unit, in regular treatment / follow-up and in the use of antiretroviral drugs (zidovudine / lamivudine and lopinavir / ritonavir) for at least two years, with Global Subjective Assessment = A (well nourished), who accepted to participate in the research with prior signature of the Informed Consent Term (TCLE)	Exclusion criterion were: patients who started treatment less than 2 years ago; with comorbidities; with a history of gastrointestinal tract operations; who used drugs that induced metabolic changes, as well as drug addicts and alcoholics. Also excluded were clinically severe or unstable patients, in addition to pregnant or infants; people with some mental disorder; who used glutamine or other supplement; patients with Global Subjective Evaluation B or C (moderately undernourished or severely undernourished) and patients who did not agree to participate in the study or did not sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-7j96vz	Physiological curve of body temperature and implications for occurrence of undesirable events among university students	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2212	Physiological curve of body temperature and implications for occurrence of adverse effects between university	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-23	Universidade Federal Fluminense	Jennifer Costa Sales Honorato	https://ensaiosclinicos.gov.br/rg/RBR-7j96vz	<NULL>	Healthy volunteers, age from 18 to 44 years; of both genders; Undergraduate students of the Nursing course at the Federal Fluminense University, individuals who have e-mail and cell phone numbers to receive research notifications and who entered the college entrance examination.	Individuals with some recurrent acute infectious process; with conditions that cause sensitivity in the region of the wrists; Individuals with known endocrine disfunctions that have an impact on thermoregulation (hyperthyroidism / hypothyroidism, hypopituitarism, myxedema, pheochromocytoma; pregnant women and patients with pacemakers)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-74snst	Mobile application as a means for pregnant women to participate in all pre-natal consultations	Recruiting	Intervention	2018-09-18	<NULL>	<NULL>	2213	Mobile application as a tool for adherence of pregnant women to prenatal care.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-74snst	<NULL>	pregnant women from 15 years of age; be attended at the Basic Unit of Health of choice for the study; have cognitive ability to participate in the research; know how to read; have a smartphone that supports the application and have access to the internet.	Pregnant women from the third trimester of gestation and who are not registered in the Basic Health Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-53ds9z	Effects of short-term memory therapy using spoken stimuli and reading stories in children who do not understand what they read	Data analysis completed	Intervention	2018-09-19	<NULL>	<NULL>	2214	Effects of the intervention in phonological memory and shared reading of history in school children with difficulties in reading comprehension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulos	FAculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53ds9z	<NULL>	age between 8 and 10 years and 11 months; attending the fourth or fifth year of elementary school; not having speech therapy because of difficulties in reading, writing and speaking; have no syndromes or hearing or visual loss.	percentage greater than 25% of absences during the 15 days of therapy (intervention meetings); not carry out the activities during the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-37428y	Effect of myofascial massage on voice, breathing and body posture of female teachers - randomized controlled clinical trial	Recruiting	Intervention	2018-09-19	<NULL>	<NULL>	2215	Effects of Myofascial Release Therapy on voice, breathing and body posture of teachers with Musculoskeletal and Vocal complaints: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Pós Graduação Distúrbios da Comunicação Humana da Universidade Federal de Santa Maria	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-37428y	<NULL>	active teachers at all levels of education; in the age group of 19 to 60 years; with normal larynx or the following laryngeal (LA) conditions: triangular crevice of degree I or degree II; presence of musculoskeletal and / or vocal complaints.	professor of Brazilian Language of Signs, support rooms, singing and or music; Physical Education or in administrative activities; history of neurological, gastric, psychiatric, endocrinological, rheumatic, musculoskeletal, degenerative or pulmonary diseases; Hearing Loss; orthopedic trauma or craniofacial malformations, whiplash injury, neck surgical scars, radiotherapy and laryngeal surgery; under phonoaudiological, physiotherapeutic and / or otorhinolaryngological treatment; amateur or professional singer; habits of alcoholism and / or smoking; diagnosis of dysphonia or other AL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-7zt98f	Electrostimulation and Exercises in Postural Low Back Pain	Recruitment completed	Intervention	2018-09-19	<NULL>	<NULL>	2216	Core associated with the russian current in patients with postural back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7zt98f	<NULL>	Young adult women; ages between 18 and 35 years; presenting chronic non-specific back pain; not regular physical activity practitioners; EVA score greater than four.	Diabetes; systemic arterial hypertension (SAH); labyrinthitis; cardiovascular diseases; presence of acute inflammatory pathologies of the lumbar spine; fracture or previous surgery of the spine; neurological disorders; systemic pathology and cancer patients; pregnant women; loss of skin integrity at the site of application of the Russian current; who have undergone a rehabilitation program in the last three months; hypersensitivity to electrical stimulation; two consecutive absences or three alternating ones in the attendances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-9s6jpc	Evaluation of educational Actions to reduce sodium consumption in adults	Data analysis completed	Intervention	2018-09-20	<NULL>	<NULL>	2217	Evaluation of the impact of Actions to reduce sodium consumption in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Universidade Federal do Espírito Santo	Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9s6jpc	<NULL>	To belong to the studied institution and to accept to participate in the research	Cognitive limitations that impede the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8ttw3f	Association between Midazolam and Ketamine compared to Midazolam as sedative in Autistic patients that will be submitted to odontological treatment under general anesthesia	Recruiting	Intervention	2018-09-20	<NULL>	<NULL>	2218	Association between Midazolam and Ketamine as preanesthetic medication in patients with Autistic Spetrum Disorder submitted to odontological treatment under general anesthesia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital Alberto Rassi- HGG	Hospital Alberto Rassi- HGG	https://ensaiosclinicos.gov.br/rg/RBR-8ttw3f	<NULL>	Autistic disorder; dental treatment; general anestesia; physical condition ASA I and II	Lack of consent, cardiac diseases, prediction of difficult airway, renal disease, alergy or previous adverse reaction to medications of the study, impossibility to give the medication completely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5cqndz	The effects of Pain Neuroscience Eucation and Pilates on kinesiophobia in older people with chronic low back pain: randomized controlled clinical study	Recruitment completed	Intervention	2018-09-20	<NULL>	<NULL>	2219	Pain Neuroscience Eucation for the older people with chronic low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-04	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Mariane Marques de Campos	https://ensaiosclinicos.gov.br/rg/RBR-5cqndz	<NULL>	"Be 60 years old or over;
Be a carrier of nonspecific chronic low back pain;
Score at least the cut grade according to their education in the instrument: Mini Mental State Examination (MMSE);
Score up to 5 points on the Geriatric Depression Scale instrument (GDS-15);"	"Older people who underwent physiotherapeutic treatment for pain management in the last six months;
Older people who underwent surgical treatment for pain management;
Older people with diagnosis of Fibromyalgia;
Involvement in regular sports activities that have the same benefits as Pilates;
Active inflammatory diseases;
Pain related to previous fractures of the spine or lower limbs;
Neoplasms;
Death."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-63j85p	Effects of Pilates Training in Police with Back Pain	Recruitment completed	Intervention	2018-09-20	<NULL>	<NULL>	2220	Effects of Pilates Mat on Police Officers with Non-Specific Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-63j85p	<NULL>	The inclusion criteria establish that the participants must be state military police officers between the ages of eighteen and forty; to present chronic nonspecific low back pain for a period of more than six months; be willing to participate in three weekly sessions of Pilates classes for a period of four months and not present any injury or illness that prevents the performance of the physical tests or any exercise proposed by the Pilates Method intervention program.	The exclusion criteria of the present study include those police officers who do not complete all the pre and post intervention intervention tests; the police officers who do not regularly attend Pilates classes, that is, have twenty percent or more absences; suffer any type of injury, which prevents participation in the proposed tests or continuation of the training sessions and those participants requesting a dismissal of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-6pxpx9	Effect of exercise and muscle electrical contraction on the critical patient defense system	Recruitment completed	Intervention	2018-09-21	<NULL>	<NULL>	2221	"Effect of physical exercise and functional electrical stimulation on the immune system of
critical patients"	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2013-11-05	Hospital Agamenon Magalhães	Hospital Agamenon Magalhães	https://ensaiosclinicos.gov.br/rg/RBR-6pxpx9	<NULL>	Critical patients; submitted to mechanical ventilation; no signs of hypertension or hypotension; normal electrocardiogram; show no signs of respiratory distress; clinical-laboratory tests within normal values.	Patient with signs of intracranial hypertension; inability to walk without assistance before acute illness in the ICU; pregnant women; obese; use of cardiac pacemaker; diagnoses of neurological, vascular, orthopedic and oncological pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6bxq36	Effect of educational programs to promove adverse events reporting	Data analysis completed	Intervention	2018-09-21	<NULL>	<NULL>	2222	Impact of educational intervension for promotion adverse events culture	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Faculdade de Ciências Farmacêuticas Campus Araraquara UNESP	Conselho Nacional Para desenvolvimento Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6bxq36	<NULL>	Health professionals who worked in the care area of the hospital dependencies during the intervention period; in full; morning, afternoon and evening shifts; with no distinction of professional category	professionals of both genders, on health leave, maternity leave or other reasons for more than 3 months, residents and trainees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-4xjkgd	The performance of people with Down syndrome and the support provided by caregivers	Recruitment completed	Observational	2018-09-21	<NULL>	<NULL>	2223	Comparison between Functional Skills and Caregiver Assistance in People with Down&apos;s Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-05-26	Universidade de São Paulo-Faculdade de Saúde Pública	Universidade de São Paulo-Faculdade de Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-4xjkgd	<NULL>	children and adolescents; medical diagnosis of DS; both sexes.	presence of severe visual and/or hearing impairment; diagnosis of autism and/or other associated syndromes; diagnosis of neurological damage and/or the use of anticonvulsant medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-8vzwdg	Study of the factors that influence the treatment of blind individuals with ocular prosthesis.	Recruitment completed	Intervention	2018-09-24	<NULL>	<NULL>	2224	A qualitative and quantitative study of the factors that influences the prosthetics rehabilitation of anophtalmic patients.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-25	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8vzwdg	<NULL>	Part 1: adult subjects. both sexes; non-users of ocular prosthesis; good general health; understand the Portuguese language; anophthalmic cavity with space. Part 2: adult individuals; both sexes; users of ocular prosthesis; good general health; understand the Portuguese language.	Part 1: local inflammatory or infectious disease; neoplasms or other deformities not previously treated; presence of oculo-palpebral prosthesis; alcoholism; serious diseases; preconceived cognitive function; impossibility of attending to the returns. Part 2: local inflammatory or infectious disease; neoplasms or other deformities not previously treated; presence of eye-palpebral prosthesis; Use of antibiotic and/or topical or systemic corticosteroids in the last 3 months; alcoholism; serious diseases; preconceived cognitive function; impossibility of attending to the returns.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-26gq5n	IONTOFORESE IN LATERAL EPICONDYLITIS OF ELBOW	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2225	Effect of the Iontophoresis in the Lateral Elbow Epicondylites: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-26gq5n	<NULL>	Have signed the informed consent form (TCLE); clinical diagnosis of lateral elbow epincondylalgia (ELC), uni- or bilateral; have not received any kind of treatment.	Shoulder, neck (radiculopathy) and / or thoracic region dysfunction; local or generalized arthritis; neurological deficit; trapping of the radial nerve; limitations in arm functions; Have received conservative treatment for ELC within four weeks before entering the study; neoplasia diagnosed at the treatment site; patient with a history of adverse reaction or hypersensitivity to electrical stimulation; contraindications to the medication to be administered; pain or symptoms of unknown origin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-93hyn7	Goal-directed training to the level of trunk control and reaching in preterm infants	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2226	Effect of goal-directed training to the level of trunk control and reaching in preterm infants at the onset of reaching ability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-93hyn7	<NULL>	Extreme preterm infants with hospital discharge and low birth weight; very preterm and preterm infants moderately and late with adequate weight for gestational age, between the 10th and ninety percentile in the growth curve; both genders; age between four and six months; perform at least one and at most three ranges for one minute at the home visit.	Infants who are born with gestational age equal to or greater than 37 weeks; congenital central nervous system; signs neurological; musculoskeletal; genetic syndromes or symptoms of withdrawal symptoms associated with maternal report of abuse of alcohol and drugs; congenital infections; sensory deficits; cardiopulmonary difficulties or whose mothers have submitted episode of eclampsia or preeclampsia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5byrsc	Effect of supplementation with a synbiotic on the inflammatory response in children and adolescents with cystic fibrosis	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	2227	Effect of supplementation with a synbiotic on markers of the inflammatory response in children and adolescents with cystic fibrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5byrsc	<NULL>	Cystic fibrosis group: Children and adolescents up to and including age zero and less than or equal to 15 years; to present a diagnosis of HR based on the sweat test (sweat chloride 60 mmol / L); clinically at least 30 days prior to data collection. For controls without cystic fibrosis: children and adolescents aged 0 years and 15 years without cystic fibrosis; clinically stable at least 30 days prior to data collection	Subjects with fever, trauma, inflammatory diseases (asthma, inflammatory bowel disease, rheumatic disease), psychiatric, degenerative, cardiovascular, diabetes, glucose intolerance, renal failure, primary or secondary immunodeficiency Subjects undergoing antibiotic use at baseline, hormones, non-hormonal anti-inflammatory drugs, immunosuppressants and antihistamines, up to 30 days prior to data collection and subjects in pulmonary exacerbation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-3tq6y3	The Effectiveness of Pharyngeal Expansion Surgery Compared to Tonsil and Adenoid Removal Surgery for Treatment of Obstructive Sleep Apnea in Obese Children	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2228	The efficacy of Modified Expansion Pharyngoplasty compared to Adenotonsillectomy for treatment of OSAS in obese children	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital Estadual de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3tq6y3	<NULL>	age between 3 and 12 years old; mild to severe obstructive sleep apnea in polysomnography; child obesity (BMI greater than p95)	Age younger than3 and older than 12 years old; syndromic patients, with craniofacial alteration or neuropsychomotor impairment, patients with asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-35xhj5	Cerebral activation and behavior of the gait of women expected to fear	Recruitment completed	Intervention	2018-09-24	<NULL>	<NULL>	2229	Cerebral mapping and biomechanical pattern of the gait of women exposed by fear off fall	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-03	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-35xhj5	<NULL>	Women 60 years of age or older; present gait with and / or without auxiliary; Mine Examination of the mental state with a score from 14 considering the influence of schooling; literate or not; who agree to participate in the study.	Use of alcoholic beverage in the last 24 hours before the exam in the laboratory; report of osteoarthrosis in the vertebral column and / or endoprosthesis in lower limbs; medical diagnosis of rheumatoid arthritis; neuromuscular or neurodegenerative disease, including diabetes mellitus; sequela of neurological disease; joint pain or edema in the last 30 days; abdominal volume that prevents the visualization of reflective markers in the pelvis; Visual impairment; body mass index (BMI) equal to or greater than 30 kg / m²; use of auxiliary devices; absence of a history of falls in the year prior to the gait assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-57wppt	Project for application of Vancomycin on spinal arthrodesis with use of screws and rods	Recruitment completed	Intervention	2018-09-25	<NULL>	<NULL>	2230	Project for application of Vancomycin on surgical site of thoracolumbar spinal arthrodesis with fusion material	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-23	Hospital Cristo Redentor - Grupo Hospitalar Conceição	Hospital Cristo Redentor - Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-57wppt	<NULL>	Spinal column fracture with indication of fixation or degenerative disease with indication of spinal arthrodesis	Previous spinal arthrodesis; Known neoplasia; Denial on participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-7zmz3y	Effect of pressure splint on spasticity in the stroke	Recruitment completed	Intervention	2018-09-25	<NULL>	<NULL>	2231	Immediate effect of Johnstone pressure splint and the inhibition techniques on spasticity of plantiflexores in the stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidad Industrial de Santander	Universidad Industrial de Santander	https://ensaiosclinicos.gov.br/rg/RBR-7zmz3y	<NULL>	Age 50 to 70 years, minimal time course of evolution 6 months to 4 years, plantar flexor muscles tone up to  3 according to the Modified Ashworth Scale (MAS), Barthel Index score greater than 60, independent gait pattern with or without ambulation aids, and the ability to perform the sit to stand movement independently	Altered cognitive ability according to the Short Portable Mental Status Questionnaire or inability to follow commands; Botulinum toxin injection 6 months before the study; diabetic polyneuropathy; lower limb pain and hyperalgesia; peripheral vascular disease, fractures or musculoskeletal lesions in the paretic lower limb; and consumption of muscle relaxant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-395mfw	Effects of Resistance Training with Blood Flow Restriction on muscle strength, mass, and quality of life of Cirrhotic patients	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2232	Resistance Training with Blood Flow Restriction in Cirrhotic patients: effects on strength, muscle mass, functionality and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Cleiton Augusto Libardi	https://ensaiosclinicos.gov.br/rg/RBR-395mfw	<NULL>	Liver cirrhosis confirmed through histopathological assessment, hepatic elastography, or clinical, radiological or endoscopic criteria	Active alcohol intake in the previous 6 month; MELD score above 15; Child-Pugh class C; decompensated chronic diseases; diabetes mellitus; hepatocellular carcinoma or other neoplasms; previous liver transplantation;  severe ascites; persistent hepatic encephalopathy; clotting disorders characterized by INR superior to 1.5 or platelets inferior to 75,000; medical contraindication exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-9j3d9z	Study on Nasal Irrigation with Corticosteroid in patients with Chronic Sinusitis	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2233	"Nasal Irrigation with Corticostheroid in
Chronic Rhinosinusitis with nasal polyps:
randomized  clinical trial"	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-9j3d9z	<NULL>	Older than 18 years; chronic rhinosinusitis with nasosinusal polyposis; endoscopic nasosinusal surgery for at least 6 months; partially controlled or uncontrolled using corticosteroid nasal spray.	Refusal to participate in the study or to sign the ICF; inability to answer the questionnaires of the present study; pregnant or nursing mothers; absolute contraindication to EC use; prior diagnosis of immunodeficiencies; previous diagnosis of nasosinusal neoplasias; previous diagnosis of primary ciliary dyskinesias; previous diagnosis of cystic fibrosis; use, within 30 days prior to inclusion in the study, of oral, intramuscular or intravenous EC; use, during the study period, of oral, intramuscular or intravenous EC; nasal endoscopy evidencing an important block of the middle meatus (or nasal cavity) by polyp, edema or synechia, which does not permit visualization of the sinuses operated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-4gjhfk	Proximetacaine anesthetic effect in the eyes: comparison between eyedrops in open eyes and vaporization in closed eyes	Not yet recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2234	Anesthetic effect of Proximetacaine hydrochloride 0,5%: comparison between eyedrop instillation in open eyes and vaporization in closed eyes	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-4gjhfk	<NULL>	Adult volunteers; both genders;  consulted at the Policlinica Ronaldo Gazolla ophthalmological clinic;  need to perform aplanation tonometry for intraocular pressure measurement.	volunteers with corneal disease; Refusal in signing the informed consent; Mentally retarded that does not understand research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-3b5frf	The effect of a mouthwash on the reduction of bad breath	Data analysis completed	Intervention	2018-09-25	<NULL>	<NULL>	2235	The effect of strontium in the reduction of volatile sulfur gases in the oral cavity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-03	Universidade Estadual do Rio de Janeiro	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3b5frf	<NULL>	They were non-smokers; with no self-reported history of systemic diseases or periodontal disease; no complaints of halitosis or xerostomia; and no self-reported regular use of medicines.	Without systemic diasease; no periodontal treatment in the last 24 months; without the use of antibiotics in the last 6 months; without pregnancy; without orthodontic therapy; non-smokers; no cardiac pacemaker users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-92kmkf	Time-Response of Photobiomodulation by LEDS  On Muscular Performance	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2236	Time response by Photobiomodulation (Light-Emitting Diodes) on Muscular Performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-04	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-92kmkf	<NULL>	Male; young adults; 18-30 years; healthy; BMI 18-30 kg / m²; physically active	History of cancer in the region of the upper limbs; infection; neurological deficits; musculoskeletal lesions in the shoulder; elbow; wrist or hand before the study (6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-2b6r7q	Aleatory clinical trial: evaluation of the effect of an application for mobile phones as an aid in the prevention of Bottle Caries	Not yet recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2237	Randomized clinical trial: evaluation of the effectiveness of an application for mobile phones as an aid in the prevention of early childhood caries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-30	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2b6r7q	<NULL>	"Children aged 36-60 months; both genders; 
with high risk of dental caries; Parents or guardians must have a smartphone with Internet access; Parents or guardians must have the WhattsApp application installed on their smartphone"	Children with caries lesions with ICDAS greater than or equal to 4; Parents or guardians who can not access WhattsApp frequently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-94r9wx	Does the high level of physical activity protect the human body against the negative effects of sleep deprivation?	Recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2238	Sleep deprivation responses on cardiovascular measures in young people with different levels of physical activity submitted to a high-intensity interval exercise session	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-18	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-94r9wx	<NULL>	Low or high level of physical activity; without sleep disorders; habitual sleep of 7 to 8 hours per night; free from chronic degenerative diseases; no change in electrocardiogram at rest or during exercise; not using cardiovascular or psychotropic or vasoactive medications; present body mass index 30 kg per m2	No smoking or ex-smoker; do not consume more than 2 servings per day of alcohol; do not take coffee-type sympathomimetics or stimulants or alcohol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5zb4dg	Lasertherapy and electrical stimulation on Lateral Epicondylitis: joint function and tendon repair.	Not yet recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2239	Photobiomodulation and diadynamic currents on Lateral Epicondylitis: joint function and tissue repair	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de São Paulo	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5zb4dg	<NULL>	Volunteers will be included if they meet the following criteria: age between 18 and 70 years; less than 6 months of epicondylalgia symptoms; absence of systemic diseases; pain at palpation over the lateral epicondyle region of the elbow or common tendon pathway of the extensor muscles; pain to the movement of wrist extension against resistance Visual Analog Scale (AVE) score of pain equal to or greater than 3 and diagnosis of lateral epicondylitis of the elbow.	Will be excluded from the study volunteers who present a history of fracture in the elbow joint; carriers of osteosynthesis metal material in the upper limb; patients with cardiac pacemakers; tactile sensory deficit in the upper limb; history of conservative or surgical treatment for epicondylalgia in the last 3 months; use of anti-inflammatory medication during the experiment and volunteers who underwent corticosteroid injection in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6yf4cv	Evaluation of the effectiveness of Propolis associated with Pomegranate in Treatment of the Buccal Inflammation due denture use in elderly	Recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2240	Evaluation of the effectiveness of Propolis associated with Pomegranate in the Denture Stomatitis Treatment in elderly	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-07-11	Hospital Universitário de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6yf4cv	<NULL>	"60 years or older
Use of partial or total dental prosthesis with palatal coverage
Present denture stomatitis"	"Recent use of antibiotic or antifungal (2 months at least before the recruitment)
Cognitive decline or dementia"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5nf6wd	Community Intervention for elderly with Depression	Data analysis completed	Intervention	2018-09-26	<NULL>	<NULL>	2241	Evaluation of the feasibility of a cluter randomized controlled  trial for the Management of Depression in elderly people living in socioeconomically disadvantaged areas of São Paulo, Brazil: a pilot study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Faculdade de Medicina da Universidade de São Paulo	King's College	https://ensaiosclinicos.gov.br/rg/RBR-5nf6wd	<NULL>	Individuals aged 60 years and over, enrolled in two Basic Health Units with Family Health Strategy in the municipality of São Paulo; depression assessed with the Patient Health Questionnaire-9 (score 10 or more no PHQ-9).	Complete deafness; terminal illness; risk of suicide; or an inability to communicate (e.g., due to cognitive impairment either reported by a family member or detected by the researcher).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-4vsvy6	Music in surgeries	Recruitment completed	Intervention	2018-09-26	<NULL>	<NULL>	2242	Benefit of intraoperative Music in Orthopedic Surgeries under Spinal Anesthesia: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-20	Faculdade de Tecnologia e Ciências	Hospital Manoel Victorino	https://ensaiosclinicos.gov.br/rg/RBR-4vsvy6	<NULL>	Will be included all patients with age between 18 and 65 years, submitted to surgery of lower members, with spinal anesthesia; physical condition P1 (patients without comorbidities) or P2 (patients with comorbidities with control, for example, systemic arterial hypertension on medication and normal blood pressure values.	Patients in use or previous use (up to one year) of antidepressants or anxiolytics will be excluded; patients diagnosed with psychiatric illness using or not drug therapy; illicit drug users; patients who are unable to respond to the survey satisfactorily and those who refuse to participate in the survey. Also excluded is the patient who has already participated in the study and is undergoing a new surgical procedure and those whose surgery lasts less than one hour, in addition to cases in which there is partial or total failure of spinal anesthesia, due to the greater use of complementary sedation .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-99xnc6	Effects of physical training associated with word memorization in improving the balance of the elderly	Recruiting	Intervention	2018-09-27	<NULL>	<NULL>	2243	Effects of Cognitive motor training on postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-99xnc6	<NULL>	Elderly in the community aged 60 years or over; both sexes; functional state capable of remaining in the orthostatic position and walking without assistance; without cognitive impairment Mini Mental State Examination above 18 for illiterate and below 26 for those with educational level above 8 years; normal or corrected auditory acuity through the Whisper Test;normal or corrected visual acuity assessed by the Snellen Test; without prior experience with the Kinect Adventures system games and sign the Free and Informed Consent Form.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6wpbny	Influence of tooth protection during resin restoration: clinical trial	Recruitment completed	Intervention	2018-09-27	<NULL>	<NULL>	2244	Influence of indirect pulp protection in restorations with bul-fill ormocer based: randomizade clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6wpbny	<NULL>	"Presence of adjacent tooth and antagonist to be treated; pulp vitality and absence of painful symptomatology; teeth that never
were submitted to pulp capping; absence of history of
hypersensitivity; isthmus less than 2/3 of the intercuspal distance; teeth
permanently; adequate oral hygiene and absence of periodontal disease;
absence of systemic diseases; absence of parafunctional habits; absence
removable partial denture that rests on the tooth under study or on its
antagonist"	"Intense parafunctional habits; extensive caries lesions; pulp exposure
during caries removal or poor restoration; cavities with risk
eminent pulp exposure; spontaneous pain or percussion sensitivity"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6b2npz	Influency of the expander type on the stability of maxillary surgical expansion	Recruitment completed	Intervention	2018-09-27	<NULL>	<NULL>	2245	Influency of tooth-borne versus bone-borne on the stability of maxillary surgical expansion	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Instituto de Assistencia ao servidor público Estadual	Instituto de Assistencia ao servidor público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-6b2npz	<NULL>	patients between the ages of 17 and 60, healthy , both genders, with maxillary trasnversal deficiency	Patients with maxillofacial syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-59j8xf	Evaluation and comparison of different methodologies for the diagnosis of schistosomiasis.	Not yet recruiting	Intervention	2018-09-27	<NULL>	<NULL>	2246	Evaluation of new diagnostic methodologies for schistosomiasis mansoni in the current epidemiological scenario.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-18	centro de Pesquisas René Rachou	centro de Pesquisas René Rachou	https://ensaiosclinicos.gov.br/rg/RBR-59j8xf	<NULL>	Residents of the Santa Rita Neighborhood; both genders; over 6 years and less than 105 years.	Have received treatment for Schistosoma mansoni infection in less than 12 months from the date of collection of the biological samples; do not deliver or allow collection of biological samples.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-3zn326	Evaluation of bacteria levels and their products after root canal treatment protocol with Ultrason Activation of a calcium hydroxide solution  and the effects of endotoxins in primary root canal infections	Recruitment completed	Intervention	2018-09-28	<NULL>	<NULL>	2247	Evaluation of bacteria levels and their products after endodontic treatment protocol with Ultrasonic Activation of a calcium hydroxide solution and the effects of endotoxins in primary root canal infections	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3zn326	<NULL>	Patients of both genders; periapical bone rarefaction visible on radiography; without previous endodontic treatment, under conditions that justify the endodontic treatment; without systemic alterations, such as chronic degenerative diseases, infectious processes, autoimmune diseases or induced or acquired immunodeficiencies; absence of antibiotics in the 90 days prior to the beginning of the research	teeth with a periodontal pocket greater than 4 mm; roots with a length of less than 15 mm or greater than 25 mm; incomplete apicigenesis; loss of dental tissue that prevents absolute isolation, or root canal alterations, calcifications or resorptions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-68y7cz	How to practically adjust artificial ventilation to protect the lungs during stomach reduction surgery.	Recruiting	Intervention	2018-09-28	<NULL>	<NULL>	2248	Evaluation of Strategies for Positive Pressure Rapid Adjustment at the End of Expiration in Laparoscopic Surgery with pneumoperitoneum in Obese patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-17	Hospital Federal dos Servidores do Estado	Instituto de Biofísica Carlos Chagas Filho- UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-68y7cz	<NULL>	Will be selected for the present study adult patients with obesity class III with BMI&gt; 40 kg / m2; more than 18 years old followed by the  bariatric surgery and endocrinology services of the Servidores do Estado do Rio de Janeiro Federal Hospital and will perform bariatric surgery.	Patients or legal guardians who do not agree to participate in the study or do not authorize the participation of patients under their responsibility will be excluded from the study; patients who have not signed the term of free and informed consent before the procedure; patients with diagnosed lung disease; patients with diagnosed heart failure; patients with chest wall alterations with different cause by obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-4q3mhz	The effect of knee braces in patients with knee arthrosis	Recruitment completed	Intervention	2018-09-28	<NULL>	<NULL>	2249	Orthoses: Efficacy and Biomechanical Effects on Osteoarthritis of the knee	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4q3mhz	<NULL>	"Individuals with medial knee osteoarthritis, determined by the classification of Kellgren and Lawrence (1957) in grades 1 to 3 on the panoramic radiograph; deformity in varus of up to 10 degrees in the measurement of the anatomic / mechanical axis; individuals of both genders; age range of 60 to 75 years; individuals who did not have the surgical procedure as the first treatment option;
absence of another type of associated disease affecting the lower limbs; absence of muscular, nervous sequelae and / or previous fractures in the lower limbs; absence of neurological disorder that promotes cognitive alterations; not have used bracing prior to the study; individuals who accepted to use the orthosis as a form of treatment."	Inability to perform any of the tests; individuals who did not use the orthosis due to skin lesions; individuals who did not attend the returns for the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-57qgrj	Brief Intervention for elderly Alcoholic Beverages users	Not yet recruiting	Intervention	2018-09-28	<NULL>	<NULL>	2250	Brief Intervention for elderly Alcohol users	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Escola de Enfermagem de Ribeirão Preto - USP	Escola de Enfermagem de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-57qgrj	<NULL>	Participants will be eligible to screen those age 60 or older and have had contact with alcohol at least once in their lifetime.	The criterion of exclusion adopted will be to show visible difficulty in understanding and expressing oneself; being hospitalized due to some clinical complication; be sick and bedridden or have changed addresses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6p2vsf	Cognitive therapy may improve quality of life in people with acromegaly	Data analysis completed	Intervention	2018-10-01	<NULL>	<NULL>	2251	Think healthy: contributions of cognitive therapy to increase the quality of life in patients with acromegaly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6p2vsf	<NULL>	The criteria for inclusion in the group are patients with acromegaly in ambulatory follow-up, of both gender, aged between 18 and 70 years, with intellectual capacity to follow the intervention and who agree to participate in the study.	There are criteria for excluding the sample: suicide risk; absence of commitment to the fulfillment of written tasks and being accompanied in therapy. Sample participants shall be considered as sample loss if they are absent, not justified, for two consecutive sessions or for three alternating sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7fk9ww	Influence of core muscles in women with patellofemoral pain syndrome	Recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2252	Influence of core muscles in women with patellofemoral pain syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7fk9ww	<NULL>	retropatellar or anterior knee pain during at least two of the following activities: sitting for an extended time, climbing stairs, crouching, running, kneeling, and jumping; pain during patellar palpation; symptoms for at least 1 month, insidious onset and unrelated to the traumatic accident; pain level at least 3 on a visual analogue scale of 10cm, in the last week; More than 3 positive of the following clinical signs: Clarke test, McConnell test, Waldron test, Zohler test, upper Q test greater than 18 degrees, Noble compression test, lateral or medial patella positioning; women aged between 18 and 35 years; Ability to perform normally as activities of daily living.	Other specific knee conditions such as gonarthrosis, ligament injury, meniscus injury, patellar tendon injury, joint degeneration, osteoarthritis or referred pain from the spine; knee surgery; history of patellar displacement or subluxation; knee treatments such as arthroscopy, use of anti-inflammatories, analgesics, anesthetics, acupuncture or physiotherapy during the last 6 months; presence of neurological diseases and inflammatory processes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6b8rvt	Effects of Green Tea Supplementation after Fatty Meal in obese patients on change in blood inflammation	Not yet recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2253	Effects of acute green tea supplementation, after the ingestion of a hyperlipidic diet, in obese individuals, in  oxidative stress,  inflammatory process and in the expression of miRNAs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Medicina de Botucatu- Unesp	Faculdade de Medicina de Botucatu- Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6b8rvt	<NULL>	age greater than or equal to eighteen years and obesity (BMI greater than or equal to thirty kilograms per square meter).	Use of dietary supplements and systemic corticosteroids in the last three months, diagnosis of chronic non transmissible  diseases such as hypertension, diabetes mellitus II, dyslipidemia, thyroid disease, neoplasms, coronary artery disease, stroke, heart failure, renal or hepatic failure and allergy to food offered in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-4tk434	Evaluation of resin with antimicrobial	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2254	In situ evaluation of the microbiological behavior of acrylic resins with an incorporation of chlorhexidine	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade do Estado do Rio de Janeiro	Departamento de Prótese da Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4tk434	<NULL>	Male or female, aged between 18 to 32, healthy with no history or presence of a systemic disease, and absence of active caries or periodontal disease.	Individuals with removable prosthesis, orthodontic appliances or any dental implants; pregnant or breastfeeding; smokers; presence of cleft palate that precludes the wearing of a retainer; use of an antimicrobial mouthwash prior to enrolment in the study; and use of antibiotics against infectious diseases during the 3 months prior to the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-3w59nw	Combined effect of plyometric training with strength training with different rests on the performance of the jump space	Recruitment completed	Intervention	2018-10-02	<NULL>	<NULL>	2255	Combined effect of plyometric training with strength training in different densities on the performance of the ejambeé jump	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-27	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w59nw	<NULL>	Be a competitor of regular competitive rhythmic gymnastics training for at least two years;participate in gymnastics training at least 3x a week; be between the ages of 13 and 15; be willing to participate in all tests and training sessions; not injury or illness that prevents the physical proposed exercise described in this document	Failure to attend any of the proposed tests; failure to attend 25% or more of the training sessions; suffer any type of injury that prevents participation in the proposed tests or continuation of the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-8w35rx	Effects of an exercise protocol in standing over sedentary lifestyle of frail elderly	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2256	Effects of an exercise protocol in orthostatism over sedentary behavior of frail elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-8w35rx	<NULL>	Elderly over 60 years; diagnosis of Fragility evidenced by the presence of at least 3 of the 5 criteria: weight loss will be considered for unintentional loss greater than 4Kg in the last year or 5% of body weight, fatigue, physical inactivity, muscle weakness and slow gait; difficulty in mobility; non-participation in other exercise programs; acceptance in signing the trial Consent Form.	Inability to stay standing; impossibility to perform the exercise due to any type of clinical change or adverse effects such as pain, cardiorespiratory, orthopedic, mental or neurological changes; elderly with increased risk for falls without family or professional follow-up of a caregiver for the practice of home exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-5symrd	Comparative study between endoscopic and conventional surgery for lumbar disc herniation	Recruitment completed	Intervention	2018-10-02	<NULL>	<NULL>	2257	Randomized trial comparing endoscopic microdiscectomy and conventional open microdiscectomy for the treatment of radiculopathy due to lumbar disc herniations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Instituto de Ortopedia e Traumatologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5symrd	<NULL>	Radiating pain to lower limbs. Lumbar disc herniation with nerve compression observed in MRI. Clinical symptoms concordant with MRI images. Six weeks of conservative treatment without significant improvement. Both men and women are included.	Motor weakness grade III or less attributed to nerve compression. High migrated disc herniation. Previous lumbar surgery on the same level. Doble compression on the nerve root. Loss of disc high grater than 50%. Any other surgery contraindication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-9kyt8y	placement of hospitalized children with respiratory aid	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2258	Influence of bed positioning of patients on mechanical ventilation admitted to a pediatric intensive care unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9kyt8y	<NULL>	Will be included in the study patients of both sexes; chronological age from 28 days to 14 years incomplete; hospitalized in the PICU for more than 24 hours; using mechanical ventilation; sedated and adapted to the mechanical ventilator; with hemodynamic stability and consent of the patients parents and / or guardians by signing a free and informed consent form.	Tracheostomized patients; with previous diagnosis of pulmonary fibrosis; with unilateral lung disease; with contraindication to head elevation; and patients whose caregivers withdrew their consent from the study will be excluded from	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-5q3h2t	The analysis of the stimuli was initiated by the use of the X-Box video game associated with Kinect, on the balance, functional mobility and motor network of individuals with Down syndrome	Data analysis completed	Intervention	2018-10-02	<NULL>	<NULL>	2259	Effect of stimuli produced by X-Box Kinect on the balance, functional mobility and motor coordination of individuals with Down syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-27	Universidade Metodista de Piracicaba - UNIMEP	Associação Síndrome de Down de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5q3h2t	<NULL>	Volunteers with Down Syndrome between the ages of 4 and 14 who are able to understand the guidelines for conducting clinical trials and do not rely on help in performing the Daily Life Activities.	Volunteers with coexisting autism, cerebral palsy, blindness and deafness, previous neurological diseases, such as traumatic brain injury, muscular dystrophies and epilepsy, with institutionalized Down syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-62hsp9	Comparison of the effect of interdental toothbrush and waterpik in the cleaning around dental implants in patients wearing fixed implant-supported prothesis	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2260	Comparison of the efficacy of manual interdental toothbrush and waterflosser in the periimplantar cleaning in patients rehabilitated with fixed implant-supported prothesis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-62hsp9	<NULL>	Individuals rehabilitated with mandibular implant-supported prothesis (4 to 5 implants) type &quot;Branemark protocol&quot;; from both genders; age between 25 and 65 years; agreeing to sign the Written Informed Consent	smokers or former-smokers; individuals diagnosed with diabetes and / or immunological diseases; pregnant or lactating women; systemic use of antibiotics or anti-inflammatory drugs in the last three months; individuals requiring the use of prophylactic antibiotics for treatment; individuals who regularly or have used any type of mouthwashes in the last three months; individuals who refuse to sign an Informed Consent; patients who during the study refuse, give up or have difficulty in practicing the proposed method of oral hygiene; patients who during the study need antibiotic therapy due to any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6h8kp2	Pharmacoeconomic study of stomach reduction surgery	Not yet recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2261	Cohort study of follow-up of participants submitted to Conventional Open Bariatric Surgery versus Laparoscopic Surgery. Clinical and pharmacoeconomic evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Hospital e Maternidade São Luiz	Hospital São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-6h8kp2	<NULL>	Sign the TCLE approved by the CEP; Men and women, older than 18 years; To present a BMI greater than or equal to 35 kg / m2 associated with comorbidities or to have a BMI greater than 40 kg / m2; Clinical intractability of obesity observed by endocrinologist; Established indication for indication of bariatric surgery according to the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM) and Resolution 2.131 of 2015 of the Federal Council of Medicine (CFM).	Anesthesia risk classified as ASA IV; Portal hypertension with esophagogastric varices; Significant intellectual limitation; Current uncontrolled psychiatric disorder; Regular users of alcohol or illicit drugs; Any other prior disease that in the opinion of the investigator contraindicates participation in the study; Women of childbearing age without adequate contraception or infants; Participation in another clinical study in less than 1 year (unless justified by the investigator);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7k576j	Double treatment with Glycopyrronium and Indacaterol versus single treatment with Glycopyrronium in treatment of lung disease	Not yet recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2262	Dual therapy with Glycopyrronium and Indacaterol versus monotherapy with Glycopyrronium in treatment of Copd patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-12	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7k576j	<NULL>	Patients (men and women) with COPD confirmed by spirometry. The diagnosis of the disease will be made by performing spirometry that will confirm the obstruction to the airflow through the result of the relation between forced expiratory volume in the first second (FEV1) and forced vital capacity of less than seventy per cent after use of inhaled bronchodilator. The patient must have stable disease. No need for hospitalization in the thirty days prior to the evaluation. Preserved neurocognitive functions. Be an adult and agree to participate in the study.	Patients with respiratory tract infection or who have been hospitalized for an exacerbation in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-49ngpt	Effects of Prone and Kangaroo Positioning in preterm infants	Data analysis completed	Intervention	2018-10-04	<NULL>	<NULL>	2263	Comparison of the effects of Prone Position and Skin-to-skin contact on cardiopulmonary parameters in premature infants with Bronchopulmonary Dysplasia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-02	Hospital Agamenon Magalhães	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-49ngpt	<NULL>	Premature infants; gestational age range of 25-32 weeks; both genders; with bronchopulmonary dysplasia; cronological age between 28 and 60 days; clinically stable; using nasal cannula or oxyhood up to 40% or room air	Infants with bronchopulmonary dysplasia at invasive or noninvasive support; risk factors for respiratory instability; risk factors for cardiovascular instability; unstable to handling; contact isolation due to infection; mother´s refuse in staying in skin-to-skin contact position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-43x6kh	Effects of a intensive therapy for the legs on the way of walking and balance for people who suffered stroke.	Recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2264	Effects of Contraint Induced Movement Therapy for lower extremities on gait and balance functionality in post-stroke patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Associação de Assistência a Criança Deficiente	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-43x6kh	<NULL>	"Medical diagnosis of stroke (ischemic or hemorrhagic), with only one event, and have suffered stroke for 6 months or more at the beginning of the protocol; Clinically stable;
- Hemiparesis caused by stroke; Defict of gait caused by stroke; Hip and knee flexion intiation on the affected side; Move from sit to stand independently even with the aid of upper limbs and/or auxiliary device and/or furniture; Be able to transfer in an independent way when seated; Be able to sustain the body weight on the affected side even requiring aid from a third person, auxiliary device or furniture; Be able to walk 10 meters with or without requiring aid from a third person, auxiliary device or furniture;  Have always the same caregiver (we will accept at most 2); Be available for going to the rehabilitation center during 17 followed days (15 days for treatment, and 2 days for evaluation); Not have undergone orthopedic surgery in the last 6 months, or neuromuscular blockade in the last 3 months; Not be able to walk outside of home in an independent way."	Not accept the protocol to which was allocated by randomization; Language change that will not allow the participant to understand, as well as respond appropriately to the proposed assessment scales and exercises selected for the protocol; Clinical intercurrence between the screening and the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-8ym65t	Effects of training withi an arm ergometer adapted on the functionality and exercise capacity of COPD patients	Recruiting	Intervention	2018-10-05	<NULL>	<NULL>	2265	Effects of training withi an arm cycle ergometer adapted in functional and exercise capacity in patientes with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8ym65t	<NULL>	"Diagnosis of COPD based on clinical and spirometric criteria;
Gold classification 2 or 3 (GOLD, 2018);
Non-smokers or former smokers;
Clinically stable in the month prior to the beginning of the protocol."	"Individuals with musculoskeletal diseases that preclude participation in the protocol such as arthroses, tendinitis and upper limb (UL);
Neurological diseases with involvement of UL;
Individuals who can not complete any of the proposed activities;
Exacerbation during the collection period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6wdrhw	Study of Pegfilgrastim similar in Healthy Participants.	Not yet recruiting	Intervention	2018-10-05	<NULL>	<NULL>	2266	Phase I Clinical Study with Pharmacokinetic and Pharmacodynamic Determination of Pegfilgrastim for Subcutaneous Use in Healthy Participants.	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-01-15	CAEP - Centro Avançado de Estudos e Pesquisas	Inovatie Consultoria e Serviços em Saúde Ltda - ME	https://ensaiosclinicos.gov.br/rg/RBR-6wdrhw	<NULL>	Sign the TCLE approved by the CEP; Participants of both sexes between the ages of 18 and 55; Participant must be physically and mentally healthy through information collected from medical history, general physical examination and vital signs, laboratory tests and electrocardiogram not indicating any evidence of disease; Body mass index (BMI) greater than or equal to 18.5 and less than or equal to 29.9 kg / m2.	Diagnosis of malignant disease in the last 5 years, except for successful basal cell carcinoma; Prior diagnosis of severe asthma, sickle-cell anemia or anaphylaxis; Laboratory alteration (at the discretion of the researcher) of any nature that could compromise participation in the study; Use of legal or illegal drugs; Hypersensitivity or contraindication of use to the components of the medications studied; Participation in another clinical study in a period of less than 1 year (unless justified by the researcher); Women of childbearing age without adequate contraception, pregnant or breastfeeding; Blood donation (greater than 500 mL) in the preceding 3 (three) months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-76cmjb	Study of different materials in the control of dental sensitivity	Recruitment completed	Intervention	2018-10-08	<NULL>	<NULL>	2267	Effect of different desensitizing materials on the control of dentin hypersensitivity - Clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-20	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-76cmjb	<NULL>	"Patients of both sexes, between 18 and 70 years;
Presence of at least two teeth with dentin hypersensitivity; Presence of at least one tooth with a result above 50mm on the EVA scale; Presence of exposed dentin in the cervical tooth region; With at least two hemi- affected by the hypersensitivity condition; Bone insertion level up to 3mm"	"Dental elements covered by prosthetic or endodontic treatment; Patients in constant use or with medical history marked by chronic use of analgesics, anti-inflammatories and psychotropic drugs; Patients with orthodontic appliances; Patients who have used desensitizers in the last three months; Patient who has undergone restorative treatment on the sensitive element for less than one month; Removable partial denture abutment teeth; To present lesions with great depth (&gt; 3mm) that need pulp protection;
Use of anticonvulsants, antihistamines, sedatives and / or anxiolytics regularly, or tranquilizers, analgesics and / or anti-inflammatories 72 hours before the evaluations and acid feed; Bone insertion level&gt; 3mm; Level of cognition that makes it impossible to answer the questionnaires applied"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8v2qmk	Effect of an Intervention with Food Counseling and Physical Exercise Practice on the reduction of cardiac risk and costs for the single health system in patients with high blood pressure	Recruitment completed	Intervention	2018-10-09	<NULL>	<NULL>	2268	Effect of a Nutritional Intervention Associated with Physical Exercise in reducing cardiovascular and custodial risk of the single health system in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Federal do Vale do São Francisco	Hospital Universitário da Universidade Federal do Vale do São Francisco (HU-Univasf)	https://ensaiosclinicos.gov.br/rg/RBR-8v2qmk	<NULL>	To have a diagnosis of hypertension; have an age group between 30 and 50 years; accept to participate in the research and sign the Free and Informed Consent; own mobile phone with Android system; has no medical contraindication for the practice of physical activity and must have a medical release certificate.	Patients who refuse to follow the recommendations and test protocols will be excluded; difficult contact and / or inability to return and follow up during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-32rvkt	Influence of Strength Training combined with Aerobic Exercise on muscle performance and physical capacity in subjects with Spondyloarthritis: a clinical trail	Recruiting	Intervention	2018-10-09	<NULL>	<NULL>	2269	Influence of Strength Training combined with Aerobic Exercise on muscle performance and functional capacity in subjects with Spondyloarthritis: a clinical trail	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-31	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-32rvkt	<NULL>	Patients with clinical diagnosis of Spondyloarthritis for at least 6 months, under ambulatory medical follow-up and stabilized drug therapy; age between 18 and 60 years; residing in Campo Grande and region	Participants younger than 18 years of age; diagnosed less than 6 months of age; without stabilized drug therapy; living outside Campo Grande / MS and region; in addition to those in another systematic physiotherapy program; in febrile and infectious history of stroke; Parkinson&apos;s disease; neurological gait disorders; cognitive impairment; cardiopulmonary contraindications to physical exercise; malignant neoplasia; hip and / or knee osteoarthritis; disc herniation; uncontrolled diabetes and hypertension; knee and / or hip arthroplasty performed within 3 months; arthrodesis; pregnant women; indigenous people; quilombolas and deprived of their liberty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-33vr5n	Response of blood pressure after sleep deprivation in children of hypertensive subjects submitted to a physical exercise session	Recruiting	Intervention	2018-10-09	<NULL>	<NULL>	2270	Effect of sleep deprivation on blood pressure in young normotensive children of hypertensive parents submitted to an aerobic exercise session: Evaluation of the Mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-24	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-33vr5n	<NULL>	Young adults; normotensive; with family history of hypertension; physically active; without cardiometabolic or chronic-degenerative diseases; not using cardiovascular or psychotropic or vasoactive medications; present a body mass index between 18.5 and 29.9 kg per m2	Do not smoke; do not ingest sympathomimetics such as coffee, stimulants or alcohol in the last 24 hours prior to each evaluation; do not miss any of the research steps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-5nryr5	Effect of Duloxetine on inflammation and motor symptoms in patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2271	Effect of administration of Duloxetine on inflammatory cytokines and motor symptoms in patients with Parkinson&apos;s disease - open-label study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Santa Maria	Hospital Universitário de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5nryr5	<NULL>	Age older than 40 years, thus excluding early Parkinson&apos;s Disease; with diagnosis of Parkinson&apos;s Disease; using levodopa; for at least two weeks without antidepressants; with a Free and Informed Consent Term read and signed.	If they had dementia, glaucoma or major depression; if they suffered from heart, kidney or liver disease; if they had poorly controlled blood pressure; if they suffered from rheumatological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-6s99yw	Evaluation of pneumonia number, weaning time that help in breathing and stay of hospital time of patients that breath for tracheostomy and used Machine for Help in Cough.	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2272	Evaluation of lung infection rates, weaning time and hospital admission time in tracheostomized patients who used the use of an Insufflation- Exsuflation pulmonary mechanism  when compared to those who did not use cough assit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Hospital de Clinicas da Unicamp	Hospital de Clinicas da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-6s99yw	<NULL>	Patients both male and female; aged 18 years and less or equal to 80 years; admitted to the Intensive Care Unit; tracheostomized; underwent invasive mechanical ventilation with Fio2 &lt;60% and PEEP &lt; 10 cmH2O; hemodynamically stable; subjects who agree to participate in the research must sign a free and informed consent form.	Patients who are not in the 18 to 80 age group will be excluded from the study; Major abdominal distention; Neurologic patients without ICP control (intracranial pressure); Patients with a history of asthma or severe bronchospasm;  with a history of osteosporosis, pneumothorax, pneumomediastinum, costal arch fracture, skull base fracture, and cystic fistula; Patients who are not in ventilatory weaning.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-29nbjw	Comparative Study of Maxillary Bone Preservation after Dental Extraction with Different Biomaterials	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2273	Comparative Study of Alveolar Border Preservation after Exodontia with Different Biomaterials	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-30	Universidade de Guarulhos	Universidade de Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-29nbjw	<NULL>	Individuals who sought the specialization clinic in Implant Dentistry of the University of Guarulhos and had indication of previous exodontia to the installation of implants osseointegráveis, with more than 20 years; good general health, requiring extraction of a maximum of 2 contiguous teeth in the maxilla, the teeth being condemned for periodontal reasons, root fracture, caries and unsuccessful endodontic treatment.	Individuals under 20 years of age; smoking; people with diabetes; carriers of blood dyscrasias; patients who use anticoagulants; pregnant women; infants; patients who had dental elements with active infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-4fgh4z	Analysis of the effects of a program of physical exercise using the legs in the motor function of the arms in patients who have stroke	Not yet recruiting	Intervention	2018-10-10	<NULL>	<NULL>	2274	Analysis of the effects of an aerobic exercise program using lower member in the motor function of the upper limb in chronic patients after Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-30	faculdade de medicina de ribeirão preto	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fgh4z	<NULL>	Participants should have had an episode of ischemic stroke for at least 6 months, be between 18 and 80 years old, absence of joint blockages in the upper and lower limbs, ability to walk for 6 minutes independently and get on mini-examination of mental status score according to level of schooling.	Symptomatic cardiac arrhythmia (atrial fibrillation in anticoagulation), uncontrolled arterial hypertension (at the examiner&apos;s discretion), decompensated heart failure (functional class 2, 3 or 4), severe respiratory disorders (chronic obstructive pulmonary disease, pneumonia ), impossibility of attending the appointments and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-52ty66	Evaluation of Metformin effects over bone marrow fibrosis in primary myelofibrosis patients	Recruiting	Intervention	2018-10-10	<NULL>	<NULL>	2275	Evaluation of Metformin effects over bone marrow fibrosis in primary myelofibrosis patients - a phase II, open label, trial (FIBROMET protocol)	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2018-09-19	Fundação de Amparo à Pesquisa do Estado de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-52ty66	<NULL>	Age superior to 18 years-old. Patients who agreed to be included in the study and have signed written-informed-consent. Primary myelofibrosis diagnosis confirmed by at least two different professionals of the Unicamp hematology-patology team. Patients capable of taking oral medicine. Glomerular filtration rate above 60 ml/min. Adequate liver function (bilirubin &lt; 1,5x superior limit and AST/ALT &lt; 3x superior limit). Negative pregnant test at the beginning of the study. Accepting using contraceptive methods during study duration.	Biguanide hypersensitivity. Diabetes mellitus diagnosis. Chronic alcohol intake. Patients who are planned to be submitted to sequential image studies using iodine contrast. Untreated vitamin B12 deficiency. Being pregnant or breastfeeding. Ongoing HIV or hepatitis B/C infection. Active autoimmune diseases. Uncontrolled comorbidities: systemic arterial hypertension, cardiac insufficiency, ischemic heart diseases, cardiac arrhythmia, chronic diarrhea. Severe psychiatric disorders or social conditions that may limit adherence to the protocol and autonomy. Anagrelide and/or Ruxolitinib use in the sixty days that precede patient´s inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-4jmz36	Can a dental care intervention reduce the risk of death of patients treated in intensive care units? A clinical randomized study	Not yet recruiting	Intervention	2018-07-10	<NULL>	<NULL>	2276	Can a dental care intervention reduce the risk of death among critical patients? A cluster randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-02	Departamento de Medicina Social da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jmz36	<NULL>	The intention to treat study population will consist of any patient with ages between 18 to 100 years old admitted for ICU admission during the study period. Subsequently, in the data analysis, those who remain hospitalized for at least 72 hours and have received at least two dental treatment sessions will be considered a per protocol subpopulation.	Patients who cross the washout period, ie remain in the ICU after the interval of 1 month between the alternation of intervention to control conglomerates and vice-versa, will be excluded from the study. This exclusion will only be from the database for analysis. This does not imply the interruption of dental care if the patient needs it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-62kr6f	Effects of two different physical training associated with diet on health in obese	Recruitment completed	Intervention	2017-09-06	<NULL>	<NULL>	2277	Effects of high intensity interval training and moderate continuous associated with diet on cardiometabolic parameters in obese	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-12	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-62kr6f	<NULL>	Volunteers should not be engaged in exercise programs; body mass index between 30 and 39,9; body mass stability in the last six months.	Current smokers; body mass index greater than 40; have a clinical diagnosis of chronic non-communicable diseases; pregnant; postpartum; breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-5ggyf5	Biocompatibility of adhesive restorative materials on human teeth	Recruitment completed	Intervention	2018-10-10	<NULL>	<NULL>	2278	Immunohistochemical Expression of Metalloproteinases and Inflammatory Proteins after the use of adhesive restorative materials in human teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Faculdade de Odontologia de Pernambuco	Faculdade de Odontologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5ggyf5	<NULL>	Healthy volunteers; Both genders; non smokers; Age between 18 and 40 years; Who have fully erupted third molar teeth; Without caries; vital; With complete rhizogenesis; and adequate oral health	Patients who do not have third molar teeth or are not indicated for exodontia; Carriers of systemic and / or oral alterations; Teeth that present restorations on any surface or negative response to the thermal test of cold pulp sensitivity; Impossibility of absolute isolation; Teeth with root resorption	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-43wzk4	Laser and the Pilates Method for Non-Specific Chronic Lower Back Pain	Not yet recruiting	Intervention	2018-10-11	<NULL>	<NULL>	2279	Effects of Laser and the Pilates Method on Non-specific Chronic Low Back Pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-08	Unidade de Ensino Superior do Sul do Maranhão	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-43wzk4	<NULL>	Patients with clinical diagnosis of chronic non-specific low back pain; Age greater than 18 years and less than 40 years; Both sexes; That they do not present another pathology in the vertebral column.	"Carriers of systemic diseases; that they are performing another type of treatment; individuals with neurological disorders; with diagnosis of; vascular disease and metabolic disease; with the presence of neoplasias;
That they are in effect of any anti-inflammatory or analgesic drug by prescription or self-medication; individuals who score on the Visual Analogue Scale less than 2;and those that do not fit the inclusion criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-3v26fm	Evaluation of the quality of scars resulting from the treatment of burn sequelae with or without the use of dermal matrices	Recruitment completed	Intervention	2018-10-15	<NULL>	<NULL>	2280	Evaluation of clinical and biomechanical features of scars comparing dermal matrices in burns sequelae	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-05	Hospital das clínicas da faculdade de medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das clínicas da faculdade de medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3v26fm	<NULL>	Patients with a burn sequel with aesthetic impairment or functional restriction, with at least one year of post-burn follow-up, with indication of surgical treatment using partial skin graft with or without dermal matrix. In addition, patients included should have at least one hypertrophic scar from the burn, for purposes of comparison between study groups.	Patients who eventually lose follow up or who progress with a loss of more than 10% of the partial skin graft at the time of surgical treatment of the burn sequel will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-47ynbw	Evaluation of the results of reconstruction surgery of the anterior cruciate ligament of the knee with graft of the contralateral and ipsilateral patella ligament	Recruiting	Intervention	2018-10-15	<NULL>	<NULL>	2281	Evaluation of the results of ACL reconstruction surgery with contralateral and ipsilateral patellar ligament graft	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal de São Paulo / Escola Paulista de Medicina	Instituto de Pesquisa e Ensino do Hospital HOME	https://ensaiosclinicos.gov.br/rg/RBR-47ynbw	<NULL>	Both gender; age range between 18 and 35 years old; amateur soccer practitioners, with a minimum frequency of twice a week; clinical and imaging diagnosis by magnetic resonance imaging of traumatic lesion of the anterior cruciate ligament.	Patients submitted to meniscal suture, asymmetric varus alignment above 10 degrees, degrees III and IV cartilage lesions (ICRS) in femoral condyles and (or) tibial plateaus; history of knee surgery; associated capsular-ligamentary lesions: posterolateral, medial collateral ligament in grade III and posterior cruciate ligament.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-6z4t5y	The impact of a strategy to motivate people with Type II Diabetes Mellitus to walk	Data analysis completed	Intervention	2018-10-16	<NULL>	<NULL>	2282	Impact of motivational strategy and intention activation in the physical activity practice, walking modality, in people with Type II Diabetes Mellitus - Controlled Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6z4t5y	<NULL>	Patients diagnosed with T2DM. Older than 18 years. With medical release for the practice of PA. In regular clinical follow-up at the five above-mentioned units.	Users with mental disorders (recorded in medical records). Users in clinical conditions that made it impossible for them to perform regular PA. Users already practicing  PA prior to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-5v6g7f	Clinical study on the application of a Gel to reduce Pain in Teeth after realizing In-Office Bleaching	Recruitment completed	Intervention	2018-06-25	<NULL>	<NULL>	2283	"Comparison between the application of a Gel to reduce Dental Pain resulting from
Bleaching, before the Gel and before / after the Gel. A clinical study in patients"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5v6g7f	<NULL>	Candidates must have all teeth from canine to upper and lower canine without caries manifestations; restorations; exposed dentin and spontaneous dentin sensitivity. Can sign a free and informed consent form. Have between 18 and 40 years. Commit to attend for periodic examinations.  Have good oral and general health. Canines with color A2 or darker compared to the color scale.	Patients who have previously performed the bleaching procedure. Pregnant or nursing. Patients with tetracycline staining (grade I, II, III or IV); fluorosis or endodontic treatment in the anterior teeth. Patients with bruxism and severe periodontitis. Continuous use of some medicine with anti-inflammatory or antioxidant action. Patients who present and / or report spontaneous dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-7hf8jw	Effects of Physical Exercise on muscle mass, strength, and blood markers in HIV Patients	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	2284	"Effects of 16 weeks of Strength Training on muscle mass, strength and
markers of oxidative stress in HIV patients"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	CEFE - Programa de Pós-Graduação em Educação Física UEM/UEL	Hospital Universitário da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7hf8jw	<NULL>	Be HIV-infected; make regular and correct use of ART for at least 1 year; do not present any motor impairment that affects the performance of tests and training; do not present any severe illness; not having been involved in the last 6 months with any physical exercise program; be older than 18 years.	Are using hormones, anabolic drugs or modulating immune therapy; present state of diarrhea, nausea, vomiting or poor oral intake of food; to present systemic infection in the 30 days before the beginning of the training; present current pregnancy or lactation; present state of advanced immunodeficiency and/or opportunistic infection; present some comorbidity that prevents the practice of exercise training; present any other contraindicated medical to the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-4kqs22	REI Study - Resistance Exercise with Instability for improve cognitive health	Recruitment completed	Intervention	2018-07-09	<NULL>	<NULL>	2285	Effects of Resistance Exercise with Instability on neurocognitive functions in elderly with Subjective cognitive impairment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-16	Universidade de Pernambuco - UPE (Campus Petrolina)	Universidade Federal do Vale do São Francisco - UNIVASF	https://ensaiosclinicos.gov.br/rg/RBR-4kqs22	<NULL>	The eligibility criteria will be: i) age between 65-80 years; ii) physically inactive (structured exercise classes in the last 3 months); iii) Montreal Cognitive Assessment (MoCA) score lower than 26 (out of a total of 30); iv) absence of clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit; v) no previously diagnosed cerebrovascular, neurological or psychiatric disease; and vi) have sufficient visual and hearing capacity to complete cognitive assessment protocol.	Exclusion criteria: clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit; previously diagnosed cerebrovascular, neurological or psychiatric disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-2tstxd	Combined treatment with conventional chemotherapy and green tea capsules for elderly acute myeloid leukemia patients	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2286	Green tea as immunomodulation and antineoplastic therapy for elderly Acute Myeloid Leukemia unfit for high dose conventional chemotherapy	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2013-10-01	Hemocentro - Universidade Estadual de Campinas	Hemocentro - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2tstxd	<NULL>	Patients with AML according 2016 WHO classification, including de novo and secondary AML; age over 60 years; Eastern Cooperative Oncology Group (ECOG) performance status 0-3; informed consent, personally signed (or legal responsible person) and dated to participate in the study; be able to comply with study procedures and follow-up examinations; last chemotherapy regimen at least 60 days ago. Hydroxiurea use is allowed.	Psychiatric disorders that would interfere with consent, study participation, or follow-up; chronically impaired renal function (creatinine clearance &lt; 30 ml / min); inadequate liver function (ALT and AST over 2.5 x ULN) if not caused by leukemic infiltration; total bilirubin over 1.5 x ULN if not caused by leukemic infiltration; known HIV and/or hepatitis C infection; diagnosis of another malignancy, unless the patient has been disease-free for at least 5 years following the completion of curative intent therapy with the following exceptions: Patients with treated non-melanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this study if definitive treatment for the condition has been completed. Patients with organ-confined prostate cancer with no evidence of recurrent or progressive disease based on prostate-specific antigen (PSA) values are also eligible for this study if hormonal therapy has been initiated or a radical prostatectomy has been performed; history of organ allograft; patients who have an indication for and can undergo a non-myeloablative transplant procedure; cardiac Disease: Heart failure NYHA class 3 or 4; unstable coronary artery disease (MI more than 6 months prior to study entry is permitted); serious cardiac ventricular arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-2vjvxv	Effect of Periodontal Therapy in association with Probiotic in the microbial communities of the mouth and intestine.	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2287	Impact of Nonsurgical Periodontal Therapy in association with Probiotic in the intestinal and oral microbiome: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-10-08	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	Instituto de Microbiologia Paulo Góes da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2vjvxv	<NULL>	Subjects with eighteen years or more; who have at least fourteen natural teeth, excluding third molars; and advanced chronic periodontitis which is determined as pocket probing depth equal or greater than six mm in three or more periodontal sites and bleeding on probing in twenty percent of the sites examined.	"Exclusion criteria are the need for antibiotic prophylaxis; having received antibiotics therapy in the three-month period prior to the study; having received periodontal therapy in the six-month period prior to the study; chronic gastrointestinal diseases or abnormalities of the gastrointestinal tract; metabolic disorders; cardiovascular diseases; immunological disorders; HIV infection; be a smoker or have stopped smoking in less than 
five years; ongoing orthodontic treatment; have Body Mass Index  equal or greater than twenty-five; be pregnant or breastfeeding, if woman."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-9vdnz3	Ability of a Test that simulates spontaneous breathing predict successful extubation of Premature Infants: comparison between two protocols	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2288	Spontaneous Breathing Test as a predictor of successful extubation in Extremely Preterms Infants: comparison between two protocols	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Centro Universitário CESMAC	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9vdnz3	<NULL>	Preterm infants; both sexes; birth weight less than 1500g; Early Respiratory Distress Syndrome diagnostic; on invasive mechanical ventilation for more than 24 hours.	Presence of cardiac malformation, neurological dysfunction or genetic syndrome; occurrence of non-scheduled extubation or death before extubation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-88d9kg	"Effect of the application of Linfotaping ® in the immediate postoperative period of
knee on the formation of edema"	Recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2289	"Effect of the application of Linfotaping ® on intraoperative Arthroscopy of
knee joint on the formation of edema"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Estadual de Ponta Grossa	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-88d9kg	<NULL>	"Patients affected by traumatic meniscal injuries and anterior cruciate ligament injury, with indication of
arthroscopy;
Held at the HURCG orthopedics and traumatology outpatient clinic;
Both sexes;
Older than 18 years;
Less than 60 years."	"Peripheral venous insufficiency;
Deep vein thrombosis;
Remove the band before 72 hours of use;
Heart failure III-IV;
Renal insufficiency;
Infectious disease present, uncured;
Cutaneous lesions in the area where the tapes should be applied;
Perform physical therapy during the data collection;
Lymphedema before surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-89wcdn	Partial Removal of Caries in permanent teeth	Not yet recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2290	Clinical controlled trial of the Partial Removal of Carious Dentin in permanent teeth with shallow, medium and deep Caries lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-89wcdn	<NULL>	Individuals without distinction of race, sex or socioeconomic status will be included. In addition, participants should be in good general health. Informed Consent Form (TCLE) duly signed. Possess a carious lesion in premolars or molars. Positive response to the cold test with refrigerated gas at -20 ° C (Aerojet, Rio de Janeiro, RJ, Brazil). Negative sensitivity to percussion test. No history of spontaneous pain. Radiographic absence of periapical lesion and / or thickening of the periodontal ligament.	Individuals who use fixed orthodontic appliances, with bands or brackets that impair the appropriate clinical and radiographic examination and the isolation of the operative field. Carious lesions with depth less than 2 mm. Non-residents in study city or city change plan. Individuals with allergy to some study material. Pregnant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-64vbk2	Dorsal musculature activity in undergraduate teachers	Data analysis completed	Intervention	2018-10-19	<NULL>	<NULL>	2291	Electrical activity of the paraespinal muscles in the flexion and extension of the column in teachers of the dynamic faculty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-20	Faculdade Dinâmica do Vale do Piranga	Faculdade Dinâmica do Vale do Piranga	https://ensaiosclinicos.gov.br/rg/RBR-64vbk2	<NULL>	Be part of the staff of the Dynamic College of Piranga Valley and sign the Term of Consent Free and Clarified	Severe postural deviations; acute musculoskeletal dysfunctions; neurological changes; pregnancy; trauma to the lower back and menopause.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-4qjdxq	Effect of transcutaneous electrical nerve stimulation on the neurogenic bladder and bowel in children with neurological dysfunctions	Recruiting	Intervention	2018-10-22	<NULL>	<NULL>	2292	Effect of Parasacral Neuromodulation on the neurogenic bladder and bowel in children with neurological dysfunctions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Instituto Santos Dumont	Instituto Santos Dumont	https://ensaiosclinicos.gov.br/rg/RBR-4qjdxq	<NULL>	"Children between 2 and 18 years of age.
Children diagnosed with neurogenic bladder and bowel due to myelomeningocele."	"Lack of fundamental information in the medical records (complementary image and developmental data).
Children with non-drained / controlled hydrocephalus.
Children who have uncorrected spinal cord.
Miss 2 times to the meeting with the physiotherapy.
Do not complete 12 weeks of home treatment.
Do not adhere to treatment.
Have undergone sacral neuromodulation treatment in the last year or initiate other concurrent therapeutic modalities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8prx2m	Influence of sleep, exercise and cold application on kicking in socccer	Not yet recruiting	Intervention	2018-10-22	<NULL>	<NULL>	2293	Influence of sleep quality, postactivation potentiation and cold-water immersion on kicking mechanics and performance in young soccer players	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Estadual Paulista	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8prx2m	<NULL>	"Football practitioners, since 6 years-old
Aged between 15 and 17 years old (under 17 group)
Consent form also signed by the parents or guardians."	"Musculosqueletal injury in the last 6 monhts;
Training/ had trained or competing/ had competed at older age groups (e.g. under 20 and professional senior)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-63nqk4	Does massage increase mobility in muscles with rigidity?	Recruitment completed	Intervention	2018-10-22	<NULL>	<NULL>	2294	Does the connective tissue release increase range of motion in muscles with plastic hypertonia?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-63nqk4	<NULL>	Elderly between 60 and 90 years old, of both genders, with Parkinson&apos;s disease and elderly between 60 and 90 years old, of both genders, neurologically healthy. Elderly patients with Parkinson&apos;s disease should present minimum muscular rigidity 1 in item 22 of the UPDRS III (motor).	Participants will be excluded if they present musculoskeletal conditions that contraindicate deep neck massage, such as a history of cervical trauma, disc herniation, cervical protrusion or skin continuity solution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-2t54nx	Selective Removal of Carious in Primary Teeth using Laser: Assessment of Patient Anxiety and Performed Restorations	Data analysis completed	Intervention	2018-10-22	<NULL>	<NULL>	2295	Selective Removal of Caries Lesions using ER Laser:YAG in Primary Molars: Assessment of Patient Anxiety and Longitudinal Clinical Analysis of Restorations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-06	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2t54nx	<NULL>	The inclusion criteria of the children were: two active caries lesions  in dentin; primary molars with pulp vitality; primary molars with absence of sealants; absence of amalgam restorations; absence of glass ionomer cement; absence of composite resin restorations.	First molars without pulp vitality; presence of sealants; presence of amalgam restorations; presence of glass ionomer cement; presence of composite resin restorations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-8c7xzn	The effect of the use of Infrared Radiation Station on patients with Limb Venous Úlcers	Recruitment completed	Intervention	2018-10-22	<NULL>	<NULL>	2296	The effect of the use of Infrared Radiation Station on patients with Limb Venous Úlcers: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8c7xzn	<NULL>	to be over 18 years of age; Present medical diagnosis of chronic venous insufficiency recorded in the medical record; Being in medical follow-up at the Vascular Surgery Service of the Charity Hospital of Ijuí; No ulcer with arterial, neuropathic or mixed etiology.	to present irregularities in the frequency of attendance at the consultations; Discontinuity and nonadherence in ulcer treatment; Infected ulcer; Ischemia in the affected limb.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-7q4sdy	Effects of Infrared and water exercise in patients with fibromyalgia	Data analysis completed	Intervention	2018-10-24	<NULL>	<NULL>	2297	Effects of an infrared emitting ceramic material and hydrokinesiotherapy in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7q4sdy	<NULL>	Fibromyalgia Diagnostics; Female patients with FM (ages from 30 to 69) were selected from the Physiotherapy Clinic of the University of Southern Santa Catarina (UNISUL), Brazil.	Presence of active or previous neoplastic conditions, infection or making use of oral or local corticosteroids or anti-cytokine therapy that could influence cytokines serum levels. All of the participants were advised not to do any other regular physical activity outside the exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-2gsphv	Prevention and management of airway obstruction in children	Recruitment completed	Intervention	2018-10-24	<NULL>	<NULL>	2298	Prevention and management of airway obstruction in children: an intervention study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-2gsphv	<NULL>	Being a mother of a child born alive; be in the period between 12 to 54 hours after the birth and the tenth day of the puerperium; demonstrate physical condition, medical release for sitting or orthostatic position, no pain at the time of approach, severe bleeding, no crying, nervous, aggressive, or sleepy.	Children under 18 who were without an escort to sign the Term of Consent;who has visual or auditory deficiency, physical deficiency in the upper limbs; they presented aggressive behavior, agitation or did not interact in the first stage of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-4c575v	Effects of hip muscle strengthening on body balance in patients with chronic ankle instability	Recruitment completed	Intervention	2018-10-25	<NULL>	<NULL>	2299	Effects of hip muscle strengthening on dynamic postural control of individuals with Chronic Ankle Instability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4c575v	<NULL>	Be between 18 and 35 years old; Present history of at least one unilateral ankle sprain injury for at least 6 months; Have ankle instability; Present scores less than or equal to 25 points in CAIT; Do not have joint blockage of the movement by fixation of surgery, ankylosis or arthrofibrosis in the ankle; Have not had surgery in the lower limbs in the last 6 months; Do not be a gestational woman.	Absence of 2 consecutive days of training; Absence in at least one of the evaluations; To present pain or worsening of the clinical picture with the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9mcv8p	Exercise Program for Parkinson&apos;s Disease	Recruiting	Intervention	2018-10-25	<NULL>	<NULL>	2300	Effects of a Home Exercise Program on Motor and Non-Motor Symptoms of Individuals with Parkinson&apos;s Disease: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-11	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9mcv8p	<NULL>	Have cynical diagnosis of idiopathic PD; To be classified as stages 2 to 4 of the Hoehn &amp; Yahr Scale (HOEHN, YAHR, 1967); Presenting two or more IC symptoms, according to the Rome III Criteria (SHARIFI-RAD et al, 2017); Demonstrate ability to understand and obey simple commands; Ability to wander for at least 10m without personal assistance; Be in regular use of antiparkinsonian medications; Absence of associated pathologies that may significantly affect bowel functioning and / or postural balance and / or gait; Absence of rectal bleeding or other gastrointestinal or proctological complications.	Does not demonstrate ability to perform the proposed exercises, even after several instructions; Does not have a means of communication (telephone) for daily contact and therapeutic follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-422ssn	Evaluation of Efficacy and Gynecological Acceptability of a Product for Health Care	Not yet recruiting	Intervention	2018-10-25	<NULL>	<NULL>	2301	Evaluation of Gynecological Acceptability of Product for Health Care with Perceived Effectiveness of Hydration and Maintenance of Vaginal pH	<NULL>	3, single-arm-study, single-blind	3	<NULL>	<NULL>	<NULL>	2018-11-16	Medcin Instituto da Pele Ltda	Marjan Indústria e Comércio Ltda	https://ensaiosclinicos.gov.br/rg/RBR-422ssn	<NULL>	33 female participants; aged between 40 and 70 years; with vaginal dryness, presenting normal vaginal mucosa and who want to participate in the research	Gestation or risk of gestation / lactation; Use of anti-inflammatory / immunosuppressive / antihistamine drugs up to 3 weeks prior to screening; active cutaneous conditions; Use of other products in the genital area; Participants who use or intend to use intravaginal or systemic anti-infectives or systemic antifungal therapy during the study; Atopic or allergic history of intravaginal products; Immunosuppression by drugs or active diseases; endocrine disorders; Relevant clinical history or current evidence of alcohol or other drug abuse; Known history or suspected intolerance to products of the same category; Intense sun exposure up to 15 days before evaluation; Dermatological and / or gynecological treatments up to 4 weeks prior to screening;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-29vkvt	Effects of skin and grape seed syrup on obese subjects	Recruitment completed	Intervention	2018-10-26	<NULL>	<NULL>	2302	Effects of the supplementation of skin and seed extract of the São Francisco Valley grapes on cardiovascular, glycemic, lipidic, inflammatory responses and quality of life of adolescents and adults with excess weight	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal do Vale do São Francisco (UNIVASF)	Universidade Federal do Vale do São Francisco (UNIVASF)	https://ensaiosclinicos.gov.br/rg/RBR-29vkvt	<NULL>	Body mass index above 30 kg / m2; be sedentary.	Have diabetes mellitus; have systemic arterial hypertension; be using any method of weight loss either through lifestyle modifications, pharmacological treatment or any antioxidant and anti-inflammatory supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5h4hht	Hunter-gatherers diet in the treatment of obesity	Data analysis completed	Intervention	2018-10-29	<NULL>	<NULL>	2303	Effect of paleolithic diet in the treatment of Obesity: controlled clinical trial and systematic review	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Fundação Universidade Estadual do Ceará - FUNECE	Fundação Edson Queiroz - Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-5h4hht	<NULL>	Excess weight; consent	Pregnant women; physical or cognitive limitations; bariatric surgery; thyroid disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5nrrwc	Erva-mate influence on iron absorption from the diet in people with hereditary iron overload	Recruiting	Intervention	2018-10-30	<NULL>	<NULL>	2304	Effect of erva-mate (ilex paraguariensis st. hil.) on the absorption of iron in patients with hereditary hemochromatosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de Santa Catarina	Centro de Hematologia e Hemoterapia de Santa Catarina - HEMOSC	https://ensaiosclinicos.gov.br/rg/RBR-5nrrwc	<NULL>	hereditary hemochromatosis; live in Florianópolis, State of Santa Catarina Brazil; a minimum age limit of 18 years; maintenance treatment; homozygous for the C282Y mutation in HFE; absence of anemia and a minimum interval of one month from the last phlebotomy.	Use of chelating agents 24 hours prior to the start of the study; presence of acute or chronic infections; cancer; diagnosis for secondary hemochromatosis and  in women in the menstrual phase of the menstrual cycle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9xg5qs	Strength training in fragile and pre-frail elderly patients at Hospital São Vicente de Paulo, Passo Fundo, RS: clinical trial	Recruiting	Intervention	2018-10-30	<NULL>	<NULL>	2305	"Training of muscular strength in the elderly with fragility or pre-fragility syndrome
hospitalized at Hospital São Vicente de Paulo in Passo Fundo-RS: trial
clinical"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-30	Universidade de Passo Fundo- UPF	Hospital São Vicente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9xg5qs	<NULL>	Aged sixty or over; length of hospital stay equal to or greater than two days and equal to or less than ten days; classified as fragile or pre-fragile	were hemodynamically unstable patients; patients with bone fractures that make intervention impossible; patients with neuromuscular diseases; patients unable to obey simple commands; patients using sedation and / or neuromuscular blockers and patients who are contraindicated to receive the NMSE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5fqjr7	Effects of guarana on physical activity practitioners	Not yet recruiting	Intervention	2018-10-30	<NULL>	<NULL>	2306	Effects of guaraná (paullinia cupana) supplementation on the regulation of oxidative stress and on blood biomarkers after physical exercise in physical activity practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-05	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5fqjr7	<NULL>	"Age between 18 and 30 years;
Do not use medicines;
That they never answer &quot;yes&quot; to the Par-Q questionnaire;
That they accept to participate in the study without any type of remuneration, besides the aid of cost related to the trip to the university in the days of the collections."	"Initiate the use of any medication during the experimental phase of the research;
Suffer some injury that is not related to the symptoms of fatigue;
Miss one of the protocol days;
Ask to leave the survey."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-4pcbrp	Physiotherapeutic treatment in patients with head and neck cancer with decreased mandibular mobility due to Radiotherapy	Recruitment completed	Intervention	2018-10-30	<NULL>	<NULL>	2307	Physiotherapeutic treatment in head and neck oncology patients with Radioinduced Trismus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Faculdade Cenecista de Bento Gonçalves	Hospital Nossa Senhora de Pompéia	https://ensaiosclinicos.gov.br/rg/RBR-4pcbrp	<NULL>	Patients with a diagnosis of head and neck cancer who are undergoing or who have undergone radiotherapy in a period of up to 365 days, of both sexes, without specific age limit, patients with radiolucent trismus, linked patients to the Cancer Institute of the Pompéia Hospital of Caxias do Sul in the state of Rio Grande do Sul	Patients with temporomandibular joint dysfunction prior to the diagnosis of head and neck cancer, patients with cognitive impairment that prevent them from performing the proposed exercises, patients who do not attend at least seven sessions of the proposed treatment or who give up participating in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-42chrz	Evaluation of Adhesive for Children&apos;s Mouth Anesthesia	Recruitment completed	Intervention	2018-10-30	<NULL>	<NULL>	2308	Evaluation of the Efficacy of a Non-Invasive Anesthetic Polymeric Device - Randomized Clinical Trial in Children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-08	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-42chrz	<NULL>	Children of both sexes; from four to twelve years; healthy; which have at least two homologous and contralateral teeth in the upper arch; with indication of similar dental procedures. Teeth requiring local anesthesia in routine clinical treatment.	Children with contraindications to the use of local anesthetics; with cognitive impairments; teeth that need treatment like pulpotomy; endodontic treatment; extraction of teeth with more than two thirds of the root; deep cavity restorations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-34w59y	Effects of hydrotherapy in preterm infants admitted to the neonatal intensive care unit	Recruitment completed	Intervention	2018-11-01	<NULL>	<NULL>	2309	Effects of Aquatic Physical Therapy in prematures of the neonatal intensive therapy unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-06	Centro Universitário Franciscano	Daniela Cristina Rambo	https://ensaiosclinicos.gov.br/rg/RBR-34w59y	<NULL>	Premature infants hospitalized in the period from November 2017 to May 2018; who are stable; in ambient air or oxygen therapy via nasal glasses; minimum stay in the Neonatal Intensive Care Unit for 7 days; premature infants in orogastric feeding and signed Consent Form; by parents and / or guardians agreeing that the newborn participates in the study.	Premature infants in invasive mechanical ventilation or non-invasive mechanical ventilation; in the pre or postoperative period; with skin lesions; with neurological diseases; with sedatives; without the prescription of physical therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-62wfjg	Ventilation Effects of Two-Phase Pressure compared to conventional ventilation in patients hospitalized in the ICU with community-acquired pneumonia	Not yet recruiting	Intervention	2018-11-01	<NULL>	<NULL>	2310	Effects of Ventilation Positive Biphasic Pressure compared to Protective Ventilatory Strategy in intensive care patients with Community-Acquired Pneumonia: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Hospital Pró Cardíaco	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-62wfjg	<NULL>	Signs and symptoms of pneumonia according to current guidelines; Age greater than 18 years;Being on invasive mechanical ventilation for up to 24 hours;Free and informed consent form obtained from the family	Transplantation (Organ and / or bone marrow);HIV positive;Immunosuppressive treatment (Corticosteroid);Tuberculosis; Hospitalization in other ICUs or emergency department in the last 14 days; Pregnancy; morbid obesity;severe liver disease;Pneumothorax;Clinical decision on palliative care;Estimated duration of mechanical ventilation less 48 hours;Neoplasms and neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9ptq49	Maternal vitamin D levels on modulation of maternal and newborn inflammation	Data analysis completed	Observational	2018-11-05	<NULL>	<NULL>	2311	Vitamin D status and repercussion in the modulation of NFkB pathway in placenta and in neonatal clinical and anthropometric parameters	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Hospital Guilherme Álvaro	https://ensaiosclinicos.gov.br/rg/RBR-9ptq49	<NULL>	Healthy mothers; single fetus; submitted to normal delivery or cesarean; with no history of clinical or obstetric complications.	Chronic diseases and / or comorbidities; prematuriry; uterine abnormalities; fetal death; multiple birth; smoking, alcohol use and illicit drug use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-36nrm6	Evaluation of sleep quality of athletes on aspects involving physical training and competition period.	Recruiting	Observational	2018-11-06	<NULL>	<NULL>	2312	Sleep quality and daytime sleepiness in athletes: relation with physical training and the period of competition.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-36nrm6	<NULL>	Age between 15 and 80 years; Be seemingly healthy; Do not present comorbidity; Being an athlete of specific modalities	Athletes who have partially responded to the collection instruments will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9q7j7y	Analysis  of physiotherapy in women who often go to the bathroom	Recruiting	Intervention	2017-06-29	<NULL>	<NULL>	2313	Effect of the physiotherapeutic treatment of surface electrostimulation in the treatment of hyperactive bladder in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Medicina da Universidade de Brasília-UnB	Faculdade de Medicina da Universidade de Brasília-UnB	https://ensaiosclinicos.gov.br/rg/RBR-9q7j7y	<NULL>	Women between 60 and 80 years old; overactive bladder diagnosis	Stress urinary incontinence; use of overactive bladder medication in the last six months; previous neurological disease; cardiac pacemaker; lower urinary tract infection; vaginal infection; vaginal discharge; vaginal redness; pain on urination; supra-pubic pain; hematuria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-3mhr3t	Gain of muscular strength in patients with cardiorespiratory diseases	Recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2314	Respiratory and peripheral muscle training in patients with Chronic Cardiorespiratory Diseases	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-3mhr3t	<NULL>	Adult individuals over 18 years old will be included; both genders; carriers of chronic cardiorespiratory diseases; with a maximum of forty-eight hours of hospitalization; signed the Informed Consent Term (TCLE).	Patients with hemodynamic instability; morbid obesity; diagnosed with neuromuscular diseases; and who have lesions on the skin at the site to be electro-stimulated will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-2hqhdp	A clinical study to assess the durability dental restorations made with bioactive restorative materials: a randomized clinical trial	Recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2315	Longevity of class II restorations performed with bioactive restorative materials: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-08-15	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - ICT UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2hqhdp	<NULL>	Patients 12 to 50 years old able to provide valid information; who require at least one class II dental restoration due to active carious lesion or exchange for poor permanent tooth restoration; the tooth selected to receive the restoration must have an antagonist and adjacent tooth; without excessive tooth wear; without evident temporomandibular disorders.	Start orthodontics during the course of the research; present allergy to any material used in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-7vznbt	Effects of a Treadmill Walking Program on stationary and moving balance in the elderly in nursing homes	Not yet recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2316	Effectiveness of a Treadmill Training Programme in improving the postural balance on institutionalized older adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7vznbt	<NULL>	Functional Ambulation Categories (FAC) &gt;2; absence of cognitive deficit in the Mini-Mental State Examination (MMSE) according to educational level; absence of physical and/or functional impairment that would limit treadmill walking.	Untreated neurological or cardiorespiratory diseases; limitation of the ability to walk on the treadmill; incapacitating visual or hearing deficits that would not permit the investigation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-2sn8xv	Effect of individual sound amplification apparatus and/or Ginkgo blloba in tinnitus.	Data analysis completed	Intervention	2018-11-07	<NULL>	<NULL>	2317	Efficacy of the individual hearing aid x drug interaction with Ginkgo biloba in patients with Hearing Loss and Tinnitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Anhanguera de São Paulo	Clínica da Audibel Aparelhos Auditivos	https://ensaiosclinicos.gov.br/rg/RBR-2sn8xv	<NULL>	The inclusion criteria of the patients were: individuals over 18 years of age; complaint of tinnitus (uni or bilateral) for at least three months; (single or bilateral) sensorineural or mixed hearing loss independent of degree and configuration; both male and female were recruited.	The exclusion criteria of the patients were: have used aspirin or acetylsalicylic acid (ASA) in the last month; have used of Ginkgo biloba in the last three months; on antidepressant use; with compromised middle ear (otitis or tubal dysfunction) at the time of evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-8qp5c9	Quality of life in post Stroke patients after swimming pool balance group	Recruiting	Intervention	2018-11-07	<NULL>	<NULL>	2318	Perception of the quality of life of hemiparetic patients post Stroke in a balance group in aquatic environment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8qp5c9	<NULL>	Diagnosis of stroke. Between 6 months and 5 years of injury, resulting in right or left hemiparesis, over 18 years old. Ambulators with or without attachment, for example simple cane or walking stick. Patients who are in final rehabilitation process in physiotherapy on the land, aquatic and occupational therapy, aiming to improve functions related to the gait pattern and or specific objective of improvement of the dynamic balance and performance in double task. Patients without deformities in lower limbs and collaborative patients, able to understand activities.	Diagnosis of stroke resulting in dyskinetic disorders. Deformity in lower limbs that can not be corrected with orthoses. Non-collaborative patients or who are not able to understand the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5qmqnq	Risk for Heart Disease and Physical Therapy in Primary Prevention	Not yet recruiting	Intervention	2018-11-07	<NULL>	<NULL>	2319	Cardiovascular Risk and Physical Therapy in Primary Prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-5qmqnq	<NULL>	"Age greater than or equal to 20 years;
both sexes"	"Individuals who notice excessive discomfort for the hair puncture;
or with incapacity to understand the booklet or any other aspect, that prevent the accomplishment of any stage;
carriers of proven cardiovascular disease and / or under medication for these diseases;
respiratory, genetic, hematological, oncological or other active diseases or with identifiable sequelae"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6k7dwj	Effects of orthodontic treatment on promoting neural adaptations in adults with malocclusion	Recruiting	Intervention	2018-11-07	<NULL>	<NULL>	2320	Acute and chronic effects of Orthodontic Treatment for dental Alignment promote neural adaptations in Adults with Malocclusion: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-08	Faculdade de Ceilândia da Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6k7dwj	<NULL>	Adults between 18 and 59 years old. With malocclusion presenting anterior and / or posterior crossbite, on deep bite. Open bite. Dental crowding. Angle class I, II and III malocclusion.	Participants with a PAR index greater than 15 and less than 30 will be excluded from the clinical trial. Presenting central or peripheral neurological disorders. They suffer trauma and / or have a tumor in the head and neck region. Have scars on target skin regions of procedures. Fear of applying electrodiagnostic tests. For those with pacemakers. Users of total or partial dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6h3g4k	Effects of B-alanine and sodium bicarbonate supplementation on time to finish the 5 km race.	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2321	Effects of B-alanine and sodium bicarbonate supplementation on the performance of runners of of Aracaju-se city.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6h3g4k	<NULL>	The subjects should have presented a weekly training volume between 25 and 40km; and running pace between 4.5 and 5.5 min/km (3,69 and 3,03 m/s) in a 5km run.	Absence in 10% of the training sessions during the study; absence on the assessments; runners that have consumed creatine or BA in the last 3 and 6 months; bicarbonate or caffeine in the last month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-8tb49z	Evaluation of mobile application effectiveness for caregivers of dementia elderly	Not yet recruiting	Intervention	2018-11-08	<NULL>	<NULL>	2322	Construction, validation and evaluation of mobile application for informal caregivers of demented elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-19	Universidade Estadual do Ceará - UECE	Associação Brasileira de Alzheimer- Regional Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8tb49z	<NULL>	Be an informal caregiver of an elderly person  with dementia; have an age of 18 years or more; being in the function of informal caregiver for the minimum period of 60 days; be literate; have some familiarity with the use of mobile electronic devices (smarthphone, tablet); have electronic device of the type smarthphone or tablet; accept the storage of the mobile application developed on your smarthphone or tablet; present suggestive scores of overload in two of the subscales of the Caregiver Reaction Assessment (CRA), version adapted and validated for use in Brazil.	To present some cognitive limitation of response to baseline information (questionnaires and instruments).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-8nw464	Fixation plates made with additive manufacture used in orthognathic surgery patients to correct deformities	Recruiting	Intervention	2018-11-08	<NULL>	<NULL>	2323	CAD/CAM technology in the manufacture of rigid internal fixation plates used in patients undergoing orthognathic surgery to correct dentomaxillofacial deformity.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Ciências da Saúde, Universidade de Brasília	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8nw464	<NULL>	Age equal or superior to 18 years; healthy; no history of temporomandibular dysfunction (TMD); of any gender; that are not in continuous use of medications that may interfere with bone repair / metabolism; with indication of surgical correction of combined dentomaxillofacial deformities (maxilla and mandible, maxilla, mandible and mento); who present orthodontic appliances already in the final stage of preoperative preparation for surgery and who have not received radiotherapy in the head and neck region.	complications with the non-adaptation of the customized fixation system; postoperative infection; need surgical intervention and removal of the system (any of the two systems employed).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-928rqc	The effect of Functional Cognitive Therapy (CFT) in patients with Chronic Lumbar Pain submitted to Surgery in Lumbar	Not yet recruiting	Intervention	2018-11-08	<NULL>	<NULL>	2324	Biopsycosocial effect of Functional Cognitive Therapy (CFT) in patients with Chronic Lumbar Pain submitted to Surgical Intervention in Lumbar	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-29	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-928rqc	<NULL>	"Age between 18 and 75 years;
A history of chronic low back pain lasting at least 12 weeks;
Pain equal to or greater than 3 points END;
Surgical intervention in the lumbar spine after 3 months or more;
To those who maintained pain and / or disability after surgery on the lumbar spine;
Score 14% or more for dysfunction in the Oswestry Disability Index;
Being able to walk independently with or without help;
Understand the Portuguese language of Brazil well enough to complete the questionnaires."	"Presence of red flags such as fracture, malignancy / cancer, equine tail syndrome or progressive neurological disorder, inflammatory or infectious diseases of the spine;
Suspected or confirmed pregnancy;
Suspicion of radicular pain, dominant leg pain, positive tests of neural tissue provocation and / or altered strength, reflex or altered sensitivity to the same nerve root, both evaluated clinically;
Unstable heart conditions.
All individuals will be clarified about the objectives and procedures performed in the research and will sign the Free and Informed Consent Form approved by the Ethics Committees of the Federal University of Santa Catarina - UFSC and the Governador Celso Ramos Hospital - HGCR."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7qr4rp	Carpal Tunnel Syndrome: physioterapic treatment aiming at hand and the column	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2325	Carpal Tunnel Syndrome: physioterapic intervention and avaliation with interface between hands and vertebral column	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7qr4rp	<NULL>	20 women; aged 20 to 70 years; diagnosis of carpal tunnel syndrome; conservative treatment.	Smoking volunteers; history of alcohol or drug abuse; diagnoses of the central nervous system disease, musculoskeletal disease of the upper limbs or hormonal/metabolic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-8hqwmx	Effect of memory training allied to physical exercise in adult and elderly health parameters: association with genetic variables	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	2326	Effect of cognitive stimulation allied to physical training in adult and elderly health parameters: association with genetic polimorphisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-10	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8hqwmx	<NULL>	Healthy volunteers; both genders; 50 years or older and less than 80 years old.	Persons with a frequency of less than 75% in the activities proposed by the intervention; people with illness or mental disorder diagnosed; untreated systemic diseases that make participation impossible; uncorrected auditory and visual deficits that make cognitive tests impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5ndvwr	Effects of an Exercise Program on the Cardiovascular System and Physical Endurance of Chronic Renal patients undergoing hemodialysis.	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2327	Effects of a Resistance Exercise Program on the Autonomic Cardiovascular Function and without Physical Conditioning of Chronic Renal patients under hemodialysis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Hospital Universitário da Universidade Federal do Maranhão	Clínica de Rim e Hipertensão Arterial	https://ensaiosclinicos.gov.br/rg/RBR-5ndvwr	<NULL>	Age greater than 18 years; both genders; undergoing hemodialysis for more than 3 months; who have the cognitive ability to understand the research process and sign the informed consent form; volunteer to participate in the study.	Patients with diseases or some type of musculoskeletal disability; bone or joint disorders that make evaluations and exercise protocol impossible; dialysis by catheter in the femoral artery or catheter in the jugular vein; neurological and behavioral changes that in some way render the protocol inapplicable; patients with severe cardiovascular disease; patients presenting hematocrit less than or equal to 30% and / or hemoglobin less than or equal to 10g / D; patients with untreated mitral or aortic insufficiency / stenosis; severe pulmonary conditions; pathologies that incapacitate the study (amputation of upper limbs or lower limbs, amaurosis, deep venous thrombosis); patients who already had resistance exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-794zhy	Effect of squatting posture on low back pain in adolescents and young adults	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2328	Effect of squatting posture on the improvement of myofascial low back pain and body alignment in adolescents and young adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-794zhy	<NULL>	volunteers with chronic myofascial low back pain; age between 15 e 25 years; male and female	obese; pregnant women; wheelchair users; musculoskeletal disorders in the lower limbs; pelvic girdle and spine, such as fractures; trauma; surgery; scoliosis and kyphoscoliosis; congenital deformities in the lower limbs and spine; neurological diseases; individuals with cognitive deficits and performing physiotherapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6zys9x	Use of Transcranial Direct Current Eletrical Stimulation for treatment of involuntary movements on patients with Schizophrenia	Recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2329	Use of Transcranial Direct Current Stimulation (tDCS) for treatment of Tardive Dyskinesia in schizophrenic patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-23	Faculdade de Medicina da Universidade de Brasília - FM/UnB	Faculdade de Medicina da Universidade de Brasília - FM/UnB	https://ensaiosclinicos.gov.br/rg/RBR-6zys9x	<NULL>	Individuals diagnosed with schizophrenia (DSV-V) and clinical presentation of Tardive Dyskinesia (Schooler-Kane criteria), both genders, aged between 18 and 65 years, with no changes in drug treatment in the last 4 weeks.	Pregnant, presence of skin disease in the electrode region, patients with relevant psychiatric comorbidity (chemical dependence, suicide risk), neurological diseases (epilepsy, stroke, dementia) and clinical diseases (malignant tumors, infections, cardiac).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4s55nj	Ocular anesthetic comparison between vaporization and eyedrop instilation of tetracaina 1%.	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2330	Tetracaine 1% anesthetic effect: comparison between eye drops in open eyes and spray in closed eyes	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-4s55nj	<NULL>	All the patients who came for ophthalmological consultation in Policlínica Ronaldo Gazolla -RJ from September 2017; invitations for patient participation in the study continued until the inclusion of 50 subjects.	Presence of any infectious or degenerative corneal disease; presence of disease affecting the trigeminal nerve, such as herpes zoster; patients who do not understand the research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6pxws7	The Impact of the Motivational Interview on the behaviors and conditions of individuals with disorders for the use of psychotropic substances  - a randomized clinical trial	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2331	Motivational interview on oral health actions for psychiatric patients - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	Secretaria Municipal de Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pxws7	<NULL>	adult individuals of both sexes; with at least 18 years of age; able to speak and understand the Portuguese language; diagnosed with alcohol use disorders (F.10); marijuana (F.12); cocaine / crack (F.14); ecstasy / LSD (F.16); use of multiple drugs (F.19); were followed up by a multiprofessional team of mental health from the Center for Psychosocial Care Alcohol and Drugs	individuals under the age of 18 and over 65, the edentulous, suffering from systemic diseases or severely decompensated psychoses, in addition to those who did not consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-492q8z	Effects of aerobic and resistance exercise training on the heart performance and its relationship to genetic alteration in diabetic patients - randomized controlled clinical trial	Recruitment completed	Intervention	2015-12-02	<NULL>	<NULL>	2332	Combined effects of exercise training on cardiovascular and metabolic performance and its relation to the polymorphism AMPD1 gene in diabetic patients - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-20	Universidade Federal de São Carlos	Conselho Nacional de Desenvolvimento Cientifico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-492q8z	<NULL>	"Volunteers of both genders between 30-65 years;Clinical diagnosis of type 2 diabetes, according to the American Diabetes Association; 
Clinically stable;
Non-practicing physical activity in the last six months, with sort of sedentary, according to the American Heart Association (VO2max: 30.2 ± 4 3 ml/kg/min-1)."	Smokers, elitist, in the presence of any diseases of the respiratory system and skeletal muscle, active inflammatory disease, acute or chronic, and evidence of myocardial ischemia and / or cardiovascular pathologies to clinical and / or exercise test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4c3fz2	Comparison of muscle activity of the trunk and legs in Equine therapy and in the gait of people with Down Syndrome, Cerebral Palsy and Intellectual Deficiency	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2333	Eletromiography analisys of the trunk and inferior limbs on the hippotherapy in comparision with the independent gait in subjects with Down Syndrome, Chronic not-progressive encephalopathy of childhood and Intellectual disabilities	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-02	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-4c3fz2	<NULL>	Medical referral; be regularly enrolled in APAE / Uberaba-MG; present independent gait; both genders; aged between 5 and 18 years; signature of the term of responsibility for the practice of equine therapy by parents and / or guardian; Free and Informed Consent signed by parents and / or guardians; medical diagnosis according to each group (Cerebral Palsy, Down Syndrome and Intellectual Disability); the Cerebral Palsy group, only the spastic diparetic type individuals will be included.	individuals with uncontrolled seizures; instabilities in the spine; herniated disc; shoulder and / or hip dislocations; scoliosis above 42 degrees; acute phase rheumatic processes; acute heart diseases; hydrocephalus with valve; uncontrollable fear of the animal, associated syndromes and / or behavioral changes; difficulty understanding commands / tasks; do not make frequent use of drugs such as botulinum toxin that interfere in muscle activity specifically of the muscle groups to be evaluated in this study; abandonment and / or 2 consecutive absences.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4qt84b	Education in pain and physical therapy for patients with chronic low back pain	Recruiting	Intervention	2018-11-13	<NULL>	<NULL>	2334	Physical therapy associated with pain neuroscience education for patients with chronic low back pain - blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-16	Centro Universitário Luterano de Palmas - CEULP/ULBRA	Centro Universitário Luterano de Palmas - CEULP/ULBRA	https://ensaiosclinicos.gov.br/rg/RBR-4qt84b	<NULL>	Patients referred from the Unified Health System (SUS) by the regulation system or registered at the of Physiotherapy’s School Clinical of the Lutheran University Center of Palmas (CEULP / ULBRA) that meet the following criteria: individuals older than 18 years; with chronic low back pain (over 3 months); of both sexes; score equal to or greater than 40 in the Central Sensitization Inventory.	Patients who are in legal proceedings against the company that working or worked; chronic diseases of systemic inflammatory origin; athletes; have performed surgical procedure in any region of the spine, have internal fixators in the spine, confirmed diagnosis of disc extrusion. Also excluded are patients with red flag criteria, such as history of neoplasms or tumor, human immunodeficiency virus (HIV), fever or infection in the last 30 days, sudden and severe weight loss, spine fracture, cauda equina syndrome and signs of neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-9zbphr	Effects of laser on injuries of the posterior thigh	Recruiting	Intervention	2018-11-13	<NULL>	<NULL>	2335	Effect of Photobiomodulation on Hamstring Injury rehabilitation: a randomised clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9zbphr	<NULL>	Acute grade I or II Hamstring muscle injury.	Regular use of antiinflamatories, analgesics and/or alimentary supplements; Grade III muscle injury; Neural symptoms during evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7wdrnf	Muscle strengthening and aerobic training associated with phototherapy in knee osteoarthritis.	Recruiting	Intervention	2016-08-23	<NULL>	<NULL>	2336	Muscle strengthening and aerobic training associated with Phototherapy in knee osteoarthritis.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7wdrnf	<NULL>	Patients must present age between 50 and 75 years; osteoarthritis in the knee joint (unilateral or bilateral) lasting at least two years; present pain in three of the following: up and down stairs; kneeling; sitting and standing; running; and remain standing for 2 minutes; rating Kellgren-Lawrence grade II and III; BMI less than 35.	Patients will not be included if they have uncontrolled diabetes mellitus; untreated high blood pressure; neurological deficits (motor or sensory); peripheral neuropathies; are frequent in physical activity; alcoholics; smokers; diagnosis of cancer; fibromyalgia; not to accept the participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-2gkc7t	Effects of mirror therapy on the recovery of hand movements with partial loss of motor function in patients who suffered a stroke	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2337	Effects of mirror therapy on the recovery of motor function from the paretic hand in  patients after stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Centro Universitário Maurício de Nassau	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-2gkc7t	<NULL>	Clinical diagnosis of Cerebral Vascular Accident; presenting kinetic-functional hemiparesis diagnosis; be between 40 and 70 years old; have sequelae time between 3 and 12 months; have preserved cognitive function.	Present another associated neurological disease; have sequelae of rheumatic, orthopedic, or vascular dysfunctions in the paretic hand; three consecutive sessions during the execution of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-98wgs8	The effect of Vestibular Rehabilitation on the balance of elderly women living in a long-term institution	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2338	Efficacy of Vestibular Rehabilitation in the functional balance of institutionalized elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Centro Universitário Maurício de Nassau	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-98wgs8	<NULL>	Women aged between 60 and 85 years; preserved cognitive function; accept to participate in the research.	Volunteers with presence of auditory and / or visual disturbances; use of wheelchair; with amputation and / or bed restriction; that we do not attend the treatment for at least three times without justification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5dfnxg	"Safety evaluation of cosmetic products by 
gynecologist and dermatologist in normal conditions of use"	Not yet recruiting	Intervention	2018-11-19	<NULL>	<NULL>	2339	Gynecological and dermatological aceitabiity evaluation of cosmetics products in normal conditions of u	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Ipclin - Pesquisa Clínica Integrada	Avenca Indústria Cosmética	https://ensaiosclinicos.gov.br/rg/RBR-5dfnxg	<NULL>	Female. Age 18 to 65 years. Phototype I to IV. Intact skin in the test area. Occasional user of the category products.	Cutaneous marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn). Pregnant women or infants. Subjects with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream. Subjects with a history of allergy to cosmetic products of the tested category. Recent gynecological surgeries. Vaginal discharge. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use of corticosteroids in the experimental area up to 8 days before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-98xmss	Effectiveness of strategies in adherence to diagnostic method guidelines in cancer patients.	Not yet recruiting	Intervention	2018-11-19	<NULL>	<NULL>	2340	Effectiveness of implementation strategies in adherence to PET / CT guidelines in cancer patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-98xmss	<NULL>	Physicians specializing in oncology, hematology, proctology, thoracic surgery, pneumology, radiotherapy, pediatric oncology; To present care of SUS patients with a diagnosis of cancer with indication to PET/CT.	Not applicable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-3z7srd	Serial album for correct positioning during anesthesia during cesarean sections: clinical study	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2341	Educational tchnology for the correct positioning in Spinal Anesthesia: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-12	Universidade Regional do Cariri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3z7srd	<NULL>	Pregnant aged 18 or over; With indication of cesarean section of gestation topical; with single fetus	Pregnant women who evolve with clinical or obstetric complications, who present some difficulty in understanding and verbal expression that prevents them from participating in the educational intervention or from responding to the instruments of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7xfkpx	Effect of training with instability on a platform in patients with Parkinson&apos;s disease	Recruiting	Intervention	2018-11-22	<NULL>	<NULL>	2342	Effect of postural perturbation training on the ability to recover body balance in individuals with Parkinson&apos;s disease with freezing of gait	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xfkpx	<NULL>	Participants should present a clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist; to present the gait blocking symptom, with scores greater than or equal to 4 by the New Freezing of Gait Questionnaire scale; stages 3 or 4 of the disease by the HoehnYahr modified scale, score equal to or greater than 23 in the Mental State Mini Examination, not presenting neurological or physical dysfunctions, other than those associated with the disease, that may affect balance control.	Inability to remain balanced after postural disorders due to displacement of the body support base, lack of attention to procedures or ability to understand instructions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-728mj2	Evaluation of the development of chewing, breathing, speech and swallowing functions in children with sucking habit	Recruitment completed	Intervention	2018-11-22	<NULL>	<NULL>	2343	"Longitudinal analysis of the development of orofacial morphology and physiology
in children with sucking habits"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Faculdade de Odontologia de Piracicaba-UNICAMP	Faculdade de Odontologia de Piracicaba-UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-728mj2	<NULL>	Children with established deciduous dentition and nutritive (bottle-feeding) and non-nutritive (pacifier) sucking habit	dental carie; dental anomalies of number or shape; presence of crossbite; history of oral and facial trauma; history and presence of orthodontic or phonoaudiological treatment; report of parents or caregivers or diagnosis of respiratory and food allergies; presence of a disorder of systemic or local origin that may compromise the masticatory system; use of medications that may interfere with muscular activity, directly or indirectly, such as antihistamines, sedatives, syrups, homeopathy or other drugs depressants of the Central Nervous System; patients who are not collaborating with the data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-8nbyk7	Partial restorations of posterior teeth with computerized technology	Recruiting	Intervention	2018-11-22	<NULL>	<NULL>	2344	Clinical behavior of CAD/CAM chairside onlay restorations: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8nbyk7	<NULL>	Age above 18 years; teeth with need / indication of indirect restorations with cusp coating; the cavity must be at least 2 mm deep in the occlusal cavity and the isthmus must be at least 1/3 of the intercuspal distance or at least 2 mm in length. A maximum of two wells per patient will be included.	Tooth with bone loss and tooth mobility; presence of endodontic treatment; absence of antagonist tooth and adjacent teeth; presence of occlusal parafunction, determined by the presence of excessive dental wear / loss of OVD / attrition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-78mj2c	Study about the treatment of pre-cancer skin lesions	Recruitment completed	Intervention	2018-11-26	<NULL>	<NULL>	2345	Study on 70% glycolic acid peeling associated with 5-fluorouracil 5% compared to the topical use of 5-fluorouracil 5% cream in the treatment of actinic keratosIs: a non-randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-28	Universidade de Cruz Alta	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-78mj2c	<NULL>	Over 18 years of age; clinical diagnosis of multiple actinic keratoses in the upper limbs (hands and forearms); minimum of five actinic keratoses in each upper limb; signed by the Free and Informed Consent Form.	Decompensated systemic diseases; previous treatment of actinic keratosis in the three months prior to the beginning of the study; use of topical steroids in the four weeks prior to the study; clinical suspicion of skin cancer in the upper limbs; Known hypersensitivity to 5-fluorouracil; defects in inherited or acquired coagulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-3f5rhw	Floral Therapy in the treatment of Anxiety in students of the physiotherapy course of a state university	Recruiting	Intervention	2018-11-26	<NULL>	<NULL>	2346	Floral Therapy in Anxiety Disorders in academics of the Physical Therapy course of a state university	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Hospital Universitário do Oeste do Paraná	Hospital Universitário do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3f5rhw	<NULL>	If they are considered anxious, between the ages of 18 and 30, enrolled from the first to the fourth year of the UNIOESTE Physical Therapy course, reach medium or high anxiety levels in the IDATE-T questionnaire.	Be doing treatment with allopathic, phytotherapeutic and homeopathic medicines for anxiety; use of flowers; psychological therapy; and acupuncture during the study period. And that refer some allergy / intolerance to alcoholic products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-8mng33	Comparision between Hardinge and Minimally invasive aproaches for Hip fractures treatment using Dynamic Hip Screw	Recruitment completed	Intervention	2018-11-26	<NULL>	<NULL>	2347	Comparision between Hardinge and Minimally invasive aproaches for Intertrochanteric fractures treatment using Dynamic Hip Screw	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-26	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8mng33	<NULL>	"Been brazilian
60 years old or older
Any gender
Patients with intertrochanteric fracture in codition approprated to the proposal surgical procedure
Patients that authorize their participation through the signing of the consent form"	"Patients who declared themselves indian;
Patients with intertrochanteric fractures with obliquity reverse fracture, whose treatment with DHS is not recommended;
Patients with pathological intertrochanteric fractures due to malignant or benign tumor disease;
Cases in which the anesthesia team refused to perform the intraoperative analgesia protocol chosen for the study;
Patients who needed blood transfusion in the immediate trans or postoperative period;
Patients with low level of discernment, to answer the pre and postoperative questions, of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-4smcqb	Dental sealing of teeth  with resinous materials applied by dentistry students.	Recruitment completed	Intervention	2018-07-26	<NULL>	<NULL>	2348	The success rates of glass ionomer cement and resin-based sealants placed by third-year undergraduate dental students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4smcqb	<NULL>	Presence of at least one permanently erupted posterior permanent tooth with sealant; minimum age of 12 and maximum of 32 years; do not use orthodontic appliances; not be using medication that could influence the salivary flow; not being pregnant; possibility of attending return visits.	Teeth with restorations and sealants in the same tooth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-2gfygv	Effect of transcutaneous electrical nerve stimulation on postoperative pain in patients after surgical treatment of distal radius fracture.	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2349	Physiotherapeutic treatment of patients after radio-distal fracture during the hospital and outpatient phases.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal do Triângulo Mineiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2gfygv	<NULL>	"Age greater than 18 years;
Both sexes, female or male;
Subjected to distal radio-fracture surgery with internal fixation that are hospitalized at the UFTM Clinical Hospital;
With postoperative pain complaint;
Ability to respond to assessment;
Ability to sign the TCLE;
Absence of: neurovascular lesions; pregnancy or lactation; severe arrhythmia and use of cardiac equipment; history of epilepsy; severe medical illness, such as uremia, decompensated liver cirrhosis and cancer; psychosis unable to cooperate; and experience with TENS."	"To present dehiscence or infection in the surgical incision with exposure of the injured skin;
New surgery during the period of intervention or death;
Neurovascular lesions diagnosed after hospital intervention;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-7hg48k	Validation of a psychological distress screening tool in the emergency room	Not yet recruiting	Observational	2018-11-29	<NULL>	<NULL>	2350	Validation of a psychological distress screening tool in the emergency room	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital das Clínicas Universidade Federal de Goiás - GO	Residência Multiprofissional em Saúde - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7hg48k	<NULL>	Patients admitted to the Emergency Room of the Hospital das Clínicas, Federal University of Goiás; both sexes; age from 18 years; without distinction of race, marital status, socioeconomic status and time of illness.	Patients who do not consent to participate in the research; patient who do not present their mental faculties preserved, according to the results presented in the Mine Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-8ww6vs	Electromyographic Evaluation of the Back During Equine Therapy	Recruitment completed	Intervention	2018-11-29	<NULL>	<NULL>	2351	Analysis of Neuromuscular Trunk Activation During Equine Therapy Session	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-20	Universidade Federal de Viçosa	Centro de Equoterapia Animal Amigo	https://ensaiosclinicos.gov.br/rg/RBR-8ww6vs	<NULL>	Sign the TCLE; Age between 8 years and 11 years; Good general health; To be enrolled in Ponte Nova School	Present any joint pain or musculoskeletal dysfunction, or any other diseases or disabilities that impede participation in the research; Equinofobia; Refusal to sign the TCLE and / or Term of Assent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-78zmwr	Computer games for people with amyotrophic lateral sclerosis	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	2352	Virtual work performance analysis in people with Amyotrophic Lateral Sclerosis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78zmwr	<NULL>	Medical diagnosis of amyotrophic lateral sclerosis with cognitive conditions of task comprehension (assessed by means of two attempts of each task); for inclusion in the control group, people can not have neurological impairments; authorization of the participant or their caregivers, with due signing of the informed consent form	Individuals who can not understand the guidelines in relation to the proposed task; present some limitation of movement of the upper limbs; and / or limitation in visual acuity that prevents playing the game; and / or are unable or unwilling to complete the proposed task will be excluded from the search	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-5r5dhf	Effectiveness of virtual reality, augmented reality and neurofunctional physiotherapy in postural control and cognition of individuals with Parkinson disease	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	2353	Effectiveness of virtual and augmented reality versus neurofunctional physiotherapy in the treatment of motors and non motors symptoms in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5r5dhf	<NULL>	"Medical diagnosis of Parkinson&apos;s disease according to the criteria of the London Brain Bank (Hughes et al., 1992);
Individuals over 50 years of age;
Non-institutionalized;
Mini Mental Score that does not characterize cognitive deficit;
Hohen &amp; Yahr between 1.5 to 3.0;
Patients who accept to participate in the project and sign the informed consent form according to the criteria of the Research Ethics Committee of the State University of Londrina"	"Individuals who realize other therapeutic treatment other than medication, who has a change in medication during the course of the study or who have associated diseases, such as: other neurological diseases, severe heart diseases, amputations, cognitive or comprehension deficits;
Alteration in the stabilization of doses of antiparkinsonian during the course of the study or more than three faults in the therapies will be considered as loss. There will be replacement of the losses to avoid influencing the statistical power of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-3m6gnj	Chicken Burger with Flaxseed and its Effect on Appetite and Blood Glucose	Recruiting	Intervention	2018-12-01	<NULL>	<NULL>	2354	Nutritional, Sensory Value of Chicken Burgers Prepared with Flaxseed Flour and its Effects on Appetite, Food Intake and Postprandial Glycemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Federal Rural do Rio de Janeiro	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais-Campus Rio Pomba	https://ensaiosclinicos.gov.br/rg/RBR-3m6gnj	<NULL>	eutrophic; normoglycemic; not taking medications known to affect glycemia, fat metabolism, or appetite; no body weight fluctuation ( greather than 5kg) in the past 3 months.	Smokers, consumption of more than two doses of alcohol ((greather than 20 mL) per day, type 1 or 2 diabetic or glucose intolerant, family history of type 1 or type 2 diabetes, recent changes (within less than three months) in diet or physical activity habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-64fx6x	Cross-Education in People with Parkinson’s Disease, a Short-Term Randomized Controlled Trial	Data analysis completed	Intervention	2018-12-01	<NULL>	<NULL>	2355	Effects of unilateral and bilateral training methods on motor control and strength in individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-64fx6x	<NULL>	"Clinical diagnosis of PD by neurologist or physician according to the United Kingdom Parkinson&apos;s Disease Society Brain Bank criteria;
Modified Hoehn and Yahr Scale classification between stages 1 and 3;
No cognitive impairment as assessed by the Mini Mental State Examination (MMSE). The cut-off points for inclusion were &gt; 24 points for literate individuals and &gt; 19 for non-literate individuals;
Controlled hypertension (&lt;150/90 mmHg);
Do not have extreme obesity (&gt;40 Kg/m2);
Do not have a heart pacemaker;
Do not have amputation of upper or lower limbs;
Male and female volunteers from the Federal District;
Individuals between 40 and 80 years who do not have health problems and / or disabilities that prevent them from completing the test batteries and training program or who may have their problems aggravated due to participation in the program;
Availability to participate on activities proposed by researcher;
Have not practiced vigorous exercise at least 6 months previous."	"Any kind of trauma that prevents participation in the study;
Inability to perform any of the tests that are part of the research study;
Individuals who may voluntarily want to stop their participation in research; 
Individuals who do not have availability to participate in the research activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-89qmhc	Prevention, evaluation and exercise in heart, lung and metabolic diseases	Recruiting	Intervention	2018-12-01	<NULL>	<NULL>	2356	Prevention, evaluation and therapy of rehabilitation in cardiovascular, respiratory and metabolic disorders	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-08	Hospital Universitário Lauro Wanderley	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-89qmhc	<NULL>	Individuals over 18 years of age; both genders; all socioeconomic and cultural levels; without racial or religious distinction; passive or active smoking; hypertension; diabetes mellitus; sedentary lifestyle; dyslipidemia; cardiovascular, respiratory and metabolic disorders	Individuals with clinical worsening; hemodynamic instability; psychic crisis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-2k4z6x	Polyethylene Tereftalate Tongue Scraper:User perception and influence on breath	Recruitment completed	Intervention	2018-12-01	<NULL>	<NULL>	2357	Evaluation of polyethylene terephthalate tongue scraper	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-02	Fundação da Universidade Federal de Sergipe	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-UFS	https://ensaiosclinicos.gov.br/rg/RBR-2k4z6x	<NULL>	The volunteer must have performed some treatment in the outpatient clinics of the Dentistry Department of the Federal University of Sergipe; it should have its oral volatile sulfur compound levels higher than seventy-five parts per billion at initial reading.	Smokers; alcoholics; pregnant women; patients with mental disorders that make it difficult to understand questions present on the form; patients with morphological alterations in the tongue; patients with motor dysfunction that prevents the use of the tongue scraper.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-9tvrzb	"Research of the effect x costs in the treatment of the dwelling area of coxa skin enlargement in burned patients.
Comparison between dressing with ibuprofen, foam with silicone and cellulose fiber mesh"	Recruiting	Intervention	2018-12-02	<NULL>	<NULL>	2358	Clinical cost-effectiveness test for treatment of the different area of partial thickness skin enlargement in burned patients. Comparison between polyurethane foam with ibupphrine, polyurethane foam with silicone and fiber mesh of salinized cellulose	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Unidade de Queimados da Unidade de Emergência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo-UQHCFMRP-USP	Unidade de Queimados da Unidade de Emergência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo-UQHCFMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-9tvrzb	<NULL>	Age greater than 10 years; patients submitted to partial skin grafting of 0.2 mm, removed from the thigh region with Aesculap® brand of electric dermatome.	known allergy to the components of the dressing; cognitive disorder; sensorial losses in donor areas; sedated patients or children under 10 years or with little understanding of the objectives of the studies and communication; need to modify the type of bandage during the study period; use of another model of an electric dermatome device for removal of skin; removal of skin in a thickness other than 0.2 mm; patients previously submitted to local anesthetic blocks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-6wrxxh	Infusion of stem cells in people with Chronic Obstructive Pulmonary Disease: improvement of quality of life and physical performance.	Data analysis completed	Intervention	2018-12-03	<NULL>	<NULL>	2359	Autologous Stem Cell infusion in COPD patients: impact on quality of life and physical performance.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-10-07	Faculdade de Medicina do ABC	IEP-São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-6wrxxh	<NULL>	patients aged between 40 and 70 years, of both gender, treatment optimized for COPD with grade 2 or 3 persistent dyspnea that is, they were all using beta 2 long duration associated with long-acting anticholinergic and inhaled corticosteroids, forced expiratory volume in the 1st second (FEV1) of 30-50%; possibility of being submitted to the pulmonary rehabilitation program; cessation of tobacco addiction for at least six months.	patients with: absence of emphysema on chest tomography; active pulmonary or extrapulmonary infection or history of infectious disease for less than 3 months; previous history of coronary artery disease and / or severe ventricular dysfunction; presence of pulmonary hypertension; home oxygen therapy; advanced or hepatic renal insufficiency; detected immunosuppressive or infectious diseases; carriers of known neoplasms and collagenoses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-2hrh87	The Effect of Vocal Exercises for the voice of elderly choristers	Recruiting	Intervention	2018-12-03	<NULL>	<NULL>	2360	Effects of Semi-occluded Vocal Tract Exercises for voice of elderly choristers: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2hrh87	<NULL>	Participant of a Choir of the city of Porto Alegre associated to the Federation of Choirs of Rio Grande do Sul; individuals aged 60 years and over; accept to to participate in the study by signing of the Free and Informed Consent Form.	Smokers; previous neurological diseases; history of serious vocal problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-9qvd2c	The effect of the relationship between genetic alterations in the renin-angiotensin system and the high-intensity interval physical training on blood pressure.	Recruiting	Intervention	2018-12-04	<NULL>	<NULL>	2361	"Effects of gene-environment interaction on blood pressure: renin angiotensin system and
high intensity interval training"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade do Vale do Taquari	Universidade do Vale do Taquari	https://ensaiosclinicos.gov.br/rg/RBR-9qvd2c	<NULL>	"students, teachers and employees of the University of Vale do Taquari - Univates, men and women, between the ages of 18 and 60 who participated in the project entitled &quot;Nutrigenetic aspects of biochemical, anthropometric and behavioral markers: implications for
multifactorial diseases that obtained classification of the International Physical Activity Questionnaire (IPAQ) as low physical activity."	"ndividuals who report or present medical impediments, such as: hypertension, nephropathies,
clotting disorders, known infectious-contagious disease, renal disease, adrenal disease, pregnant women, individuals with cancer and users
of drugs that interfere with glycemic, lipidic, blood pressure or appetite suppressant levels. In addition, subjects who do not
complete the training, with more than 80% attendance at the sessions, or do not complete any of the project steps."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-5fh5r4	Direct current neuromodulation and its benefits in different populations	Recruiting	Intervention	2018-12-04	<NULL>	<NULL>	2362	Transcranial direct current stimulation and its therapeutic potential in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-04	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5fh5r4	<NULL>	Man or woman aged 18 or older; be in chronic phase of chikungunya fever (least 3 month of the initial infection) and show laboratory tests or clinical diagnostic confirmation of chikungunya virus; pain related with more than 4 in a numeric rating scale; to have physical capacity to do physical evaluation and be capable of consenting to treatment and understanding study explanations and questionnaires; having provided informed consent	Electrical implants in the body; a history of epilepsy; people who are clinically contraindicated to receive tDCS such as having metal embedded in their scalp or brain; psychiatric illness, and history of drug abuse; pregnant women; signs of severity and/or indication of hospitalization; presence of previous rheumatic disease including gout, rheumatoid arthritis, fibromyalgia, lupus and others chronic pain syndromes with diagnosis prior to chikungunya	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-2m9nq2	Exercise program unsupervised in hemodyalisis patients	Recruitment completed	Intervention	2018-12-04	<NULL>	<NULL>	2363	Impact of an unassisted exercise program proposed for patients with chronic kidney disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m9nq2	<NULL>	participants with CKD on hemodialysis treatment; more than six months; both sexes; age greater than 18 years; without previous surgical history in the last six months; who agreed to sign the informed consent form	participants with clinical instability; neurological alterations; orthopedic; those who were hospitalized during the program; they used oxygen; orthopedic prosthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-5rz5ch	Effects of Nitrous Oxide augmentation of the drug treatment of Depressive Disorder	Recruitment completed	Intervention	2018-12-04	<NULL>	<NULL>	2364	Effects of Nitrous Oxide augmentation of the Selective Serotonin Reuptake Inhibitors treatment of Major Depressive Disorder	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2016-06-10	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	O Instituto Nacional de Ciência e Tecnologia Translacional em Medicina	https://ensaiosclinicos.gov.br/rg/RBR-5rz5ch	<NULL>	Patients with major depressive episode according to the DSM-5 criteria, aged between 18 and 65 years, on antidepressant treatment without dose adjustment for more than 4 weeks, and who scored &gt; 17 on 17-item-Hamilton Depression Rating Scale.	Presence of relevant clinical conditions (cardiovascular diseases, severe arterial hypertension, renal insufficiency, liver disease, hypothyroidism, chronic obstructive pulmonary disease, B12 hypovitaminosis, epilepsy, pregnancy and breastfeeding); patients with relevant psychiatric comorbidities, especially substance use disorders (except caffeine and nicotine), clinical history of hypomania or mania episode induced by antidepressant medication; patients with clinical criteria of inpatient treatment; nasal septum and difficulty in breathing through the nose.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-9xg6dx	Electronic Staining increases the Detection of Tumors of the Large Intestine and Rectum	Recruiting	Intervention	2018-12-04	<NULL>	<NULL>	2365	Linked Color Imaging improves Colorectal Adenoma Detection	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-11-08	Santa Casa de Caridade de Bagé	Santa Casa de Caridade de Bagé	https://ensaiosclinicos.gov.br/rg/RBR-9xg6dx	<NULL>	Adults aged 30 years or older who present symptoms such as altered bowel habit; abdominal pain or discomfort; abdominal distension and rectal bleeding; adequate bowel preparation;  complete colonoscopy and; who were referred for screening or surveillance.	Age less than 30 years; advanced colorectal cancer; use of antithrombotic therapy; inflammatory bowel disease;previous colorectal resection; presence of adenomas diagnosed in a previous colonoscopy; acute lower gastrointestinal bleeding; inadequate bowel preparation; or incomplete colonoscopy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-5hgxy8	A double-blind randomized clinical trial applied to lower limb diabetic ulcers using a combination of biomembrane derived from natural latex (Hevea Brasiliensis) and  light emitting equipment	Not yet recruiting	Intervention	2018-12-05	<NULL>	<NULL>	2366	"Randomized double-blind clinical trial in diabetic ulcers of lower limbs using biomembrane association derived from natural latex
(Hevea Brasiliensis) and  light emitting equipment varied wavelength 450 to 636 nm"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5hgxy8	<NULL>	"Patients aged between 18 years and 75 years;
with history of diabetes mellitus type I or II; to present a single type A1 or A2 diabetic foot ulcer (University of Texas classification, with indication of outpatient treatment, without infection and without indication of surgical debridement, with a history of diabetic foot ulcer of more than 6 weeks duration and less of 12 months, have no allergy to latex, intellectually fit, have a cell phone with the ability to take photographs and have the application WhatsApp"	Diabetes mellitus uncontrolled with glycated Hb&gt; 10 g / dl; irregular use of medication for the disease or even without regular medical follow-up; evidence of osteomyelitis or gangrene at either end; have lesions with excessive exudate; be an active smoker, regular user of alcoholic beverages and / or illicit drugs; another chronic disease that at the discretion of the investigator compromises the participation in the study; pregnant or lactating women or women of child-bearing age without adequate contraception; participation in another clinical study in less than 1 year (unless justified by the researcher)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-738h37	Effects of Strength Training with Vascular Occlusion on the physical performance and pulmonary function of people with COPD	Data analysis completed	Intervention	2018-05-01	<NULL>	<NULL>	2367	Chronic effects of Strength Training with Blood Flow Restriction on the physical performance and pulmonary function of people with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-738h37	<NULL>	Diagnostic of moderate or severe COPD (post-bronchodilatatior VEF1 between 30 and 60% of the predicted value); aging 50 years or more; clinicaly stable for at least a month before treatment (infections or acute exarcebations); non-smokers or ex-smokers for at least a year; without cardiovascular or orthopedic diseases that make impossible performing the exercises; being under medical treatment; have bachial-ankle index between 0.9 and 1.3, indicating that there is no risk of peripherical artery disease.	Will be excluded from the sample those who: exarcebate the disease during the treatment protocol; stop taking medication; present oxygen saturation smaller then 85% during exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-477y7q	Pilates exercises to improve the balance of patients with Parkinson&apos;s disease	Recruitment completed	Intervention	2018-12-06	<NULL>	<NULL>	2368	Evaluation of the effect of the use of the Pilates Method on the improvement of balance in patients with Parkinson&apos;s disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Universidade de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-477y7q	<NULL>	Volunteers with confirmed diagnosis of Parkinson&apos;s Disease; which are clinically stable through drug therapy; who can wander without help from a caregiver; with score &lt;3 on the Hoehn &amp; Yahr Scale; who may attend Pilates services; older than 39 years;	Volunteers who present with another neurological disease that compromises the evaluation of balance, such as orthopedic diseases, severe labyrinth diseases, among others; who have more than two absences to attend to Pilates; to abandon the program for some reason; who were performing some regular physical activity or physical therapy; that present some limitation and/or contraindication to perform physical activity at the moment;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2g27rd	Clinical study with the choice of patients who present wounds and the use of natural latex insole associated with light emitting circuit of leds for light therapy	Data analysis completed	Intervention	2018-12-06	<NULL>	<NULL>	2369	Randomized clinical trial of patients with wounds: natural latex and led light emitting circuit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-05	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2g27rd	<NULL>	Patients intellectually fit, with diabetes mellitus and affected by foot ulcers of neuropathic origin. With or without clinical signs of infection and after completing and signing a consent form	Pregnant women; under 18 years or over 75 years of age; with history of alcohol or drug abuse; with symptoms and diagnoses of osteomyelitis, local tissue necrosis; with cognitive, neurological, or latex hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5jt8k2	Application of physiotherapy to reduce pressure	Recruitment completed	Intervention	2018-12-07	<NULL>	<NULL>	2370	Comparative analysis between two antihypertensive manual techniques: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-27	Faculdade Independente do Nordeste - FAINOR	Faculdade Independente do Nordeste - FAINOR	https://ensaiosclinicos.gov.br/rg/RBR-5jt8k2	<NULL>	Be over 18 years old; has high BP; not presenting decompensated cardiovascular pathologies or neurological sequelae due to stroke; ability to respond to the questionnaire.	Ocular infections; use of normopressoric drugs in an infusion pump; severe pain&gt; 7	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-9d7c7b	Effects of electrical stimulation over the skull and tight together with exercises on knee osteoarthritis	Recruiting	Intervention	2016-07-18	<NULL>	<NULL>	2371	Effects of electrical stimulation over the skull and tight together with exercises on knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-12	Instituto de Ciências da Saúde da Universidade Federal da Bahia	University of Sidney	https://ensaiosclinicos.gov.br/rg/RBR-9d7c7b	<NULL>	Volunteers with knee osteoarthritis; age of 50 years; knee pain on most days of the last month; osteophytes on radiographs and pain or difficulty to sit;lifting or climbing stairs ; score in Chronic Pain Grade (GPC ) equal to or greater than II.	"Subjects with contraindications to the use of transcranial magnetic stimulation; Presence of metal in the skull and implanted devices; history of epilepsy; pregnancy, use of drugs that may interfere with the cortical electrical activity; history of diseases that may interfere with OA knee; becoming confounders such as fibromyalgia; rheumatoid arthritis, ankylosing spondylitis; systemic lupus eritemotos; fractures in the region
knee, knee replacements; back problems causing symptoms in knee and peripheral nervous impairment; individuals unable to understand the contents of the assessment tools used."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3n4tzc	Effectiveness of educational primer for caregivers of stroke patients.	Recruiting	Intervention	2018-12-10	<NULL>	<NULL>	2372	Effect of educational primer for caregivers of stroke victims: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Estadual do Ceará -  UECE	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-3n4tzc	<NULL>	Age greater than or equal to 18 years; be a ccompanying the patient during the period of hospitalization; be one of the main caregivers of the patient after discharge; and have at least one telephone contact for the researcher to contact to carry out the other phases of the research.	Caregivers who present some mental impossibility to understand interventions and those who cannot read and write. Cases of discontinuity will be considered: telephone change after follow-up, failure to answer telephone call safter three attempt sat different day sand times, caregiver whose cell phoneis out of area or disconnected for more than 10 attempts to connect in days and schedules and no longer be the caregiver of the patient suffering from stroke. The patient or caregiver who died in the course of the research will be considered a loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-6vw9dv	Physiotherapeutic treatment in seamstresses with pain in the neck and shoulder.	Data analysis completed	Intervention	2018-12-10	<NULL>	<NULL>	2373	Physiotherapeutic approach in sewing machine operators with complaints in the cervical region and shoulder.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6vw9dv	<NULL>	Individuals of both sexes, who work in industry confections in the city of Araranguá, with chronic pain in the neck and shoulder.	Individuals with pain symptoms in the neck and shoulder do not perform 80% of the proposed treatment sessions, do not tolerate treatment, individuals with cognitive deficits or neurological patterns that may compromise the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-993dm8	Effects of physical therapy session frequency no rehabilitation of children with congenital Zika Virus Syndrome	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	2374	Effects of physical therapy on motor function and neurocognitive development of children with congenital Zika virus syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Instituto de Pesquisa Professor Joaquim Amorim Neto	Instituto de Pesquisa Professor Joaquim Amorim Neto	https://ensaiosclinicos.gov.br/rg/RBR-993dm8	<NULL>	Diagnosis of SCZV confirmed by RT-PCR or presumed by imaging findings (gestational ultrasonography and / or transfontanel ultrasonography and / or tomography), and controlled seizures.	Any clinical conditions at the time of data collection that contraindicate physical therapy, such as severe malnutrition, newly performed surgery, pneumonia and other infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-8j3kmc	Three-Month Effects of Aerobic Training plus Strength Training in College Students	Recruitment completed	Intervention	2018-12-11	<NULL>	<NULL>	2375	Chronic Effects of Concurrent Training in College Students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-14	Universidade Estadual de Londrina - UEL	Universidade Estadual de Londrina - UEL	https://ensaiosclinicos.gov.br/rg/RBR-8j3kmc	<NULL>	University students; physically inactive for at least six months; absent from chronic and musculoskeletal diseases; women; age between 18 and 25 years	physically active; symptomatic of some recurrent pain; obese with imc greater than 35	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2tdcq4	Laser and stretching for pain treatment of the perineum muscles - pilot study	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	2376	Photobiomodulation and manual therapy in the treatment of myofascial dysfunction of the pelvic floor muscles - pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-28	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Universidade Estadual de Campinas -UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-2tdcq4	<NULL>	Women with 18 years of age or older with MAP myofascial dysfunction, diagnosed for pain and or discomfort during vaginal digital palpation of the pelvic floor.	Women with Urinary Tract Infection or Pelvic Inflammatory Disease at the time of study inclusion; Women with previous pelvic radiotherapy or brachytherapy; Women with a history of cervical or endometrial cancer; Pregnant women; Women who have any other medical contraindication for intravaginal access; Women who make use of analgesic, narcotic and muscle relaxant medications; Homoaffective women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-9w3k77	Study of the Analgesic Effect of Esmolol for Weight Reduction Surgery	Recruitment completed	Intervention	2018-12-11	<NULL>	<NULL>	2377	Study of the Analgesic Effect of Intraoperative Esmolol for Laparoscopic Gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Instituto de Gastroenterologia de Sao Paulo	Universidade Federal de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9w3k77	<NULL>	Volunteers between 18 and 50 years; both genders; physical state Wing I or II; submitted to gastroplasty by bypass at the Igesp hospital; who have signed the informed consent form.	Have allergy to research drugs, have respiratory disease; renal; hematological; hepatic; cardiovascular severe; bronchial asthma; psychiatric disorder; cognitive alterations; make prior use antagonists of beta adrenergic receptors;  illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-8md6c9	Effects of strength training on the shortest range of disturbances in environments of corporal achievement, strength, functional capacity, blood pressure and skin temperature in women of advanced age	Recruitment completed	Intervention	2018-12-11	<NULL>	<NULL>	2378	Effects of strength training with blood flow restriction in different environments on morphological, neuromuscular, hemodynamic, functional and inflammatory variables in middle-aged and elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Instituto Federal de Educação Ciência e Tecnologia do Ceará	Instituto Federal de Educação Ciência e Tecnologia do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8md6c9	<NULL>	Inclusion criteria: Respond negatively to all items in the Physical Activity Readiness Questionnaire / PAR-Q; not having practiced strength training for six months; present medical certificate for training participation; absence of history of cardiovascular diseases, not having or having had any type of musculoskeletal injury in the lower limbs in the last six months.	The exclusion criterion consists of: not having 75% of frequency in the training program (FERREIRA et al., 2005)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-89rd4p	Clinical study for the evaluation of different local anesthetic dental techniques	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	2379	Comparison of pain perception using conventional and computerized anesthetic techniques: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-89rd4p	<NULL>	Patients should be at least 18 years of age with chronic periodontal disease, presenting at least one vital tooth with a clinical depth of probing greater than or equal to 4 mm in at least one of the probed sites in three different hemiarcates.	Patients in periodontal maintenance; sensitivity or any form of allergic reaction to amide-based anesthetics; have used analgesic or anesthetic medication for at least 12 hours prior to the periodontal instrumentation procedure; patients with previous history of alcoholism; pregnant or lactating women; patients with severe uncontrolled systemic disease such as heart, neurological, renal, hepatic or blood problems; psychiatric problems that could interfere with the scaling and smoothing or administration of topical anesthetics and injectables. Local pathological changes such as presence of ulcerative lesions, abscesses, acute infections; need for exodontia in the study quadrant; dentin hypersensitivity; absence of vitality or other pulp pathologies that could interfere in the measurement of the data in the teeth involved in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-7cs387	Action of Chinese Auricular Acupuncture with Laser associated with Systemic Cupping  in people with Chronic Spine Pain	Recruiting	Intervention	2018-12-12	<NULL>	<NULL>	2380	Action of Chinese Auricular Acupuncture with Laser associated with Systemic Cupping on Chronic Pain in people with Musculoskeletal Disorders in the Spine: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7cs387	<NULL>	Age (18-80 years old);  Presence of chronic pain, existing for three months or more; Self-reported pain intensity, with score ? four in the numerical pain intensity scale; and time availability for laser auricular acupuncture sessions.	Infection, inflammation or injury in the Auricular pavilion; Cancer patients; Piercing use (except normal earring); Previous energy therapy, such as massage, phytotherapy, reiki, floral therapy, yoga and homeopathy up to 3 months prior to the realization of the study; Physiotherapeutic treatment concomitant with the proposed intervention; Continuous use of medication for pain relief; neurological or psychiatric disease; Refusal to receive ear treatment by means of laser; Pregnant women and not responding to three attempts at contact made by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-9832jt	Effect of the use of L-Arginine, Caffeine or Creatine supplements associated with physical activity in women with Polycystic Ovary Syndrome with Metabolic Syndrome	Not yet recruiting	Intervention	2018-12-12	<NULL>	<NULL>	2381	Thermogenic Adaptation in Patients with Polycystic Ovarian Syndrome with Metabolic Syndrome Supplemented by Chronology with L-Arginine, Caffeine or Creatine and Training Resisted Exercise - Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Mato Grosso	Instituto Tropical de Medicina Reprodutiva e Menopausa	https://ensaiosclinicos.gov.br/rg/RBR-9832jt	<NULL>	Women with PCOS who present a metabolic syndrome, with a total age of 20-35 years in the period of the research, who are sedentary or do not practice more than two days of physical exercise, will be selected in the INTRO database , and to sign the Free and Informed Consent Form (TCLE).	Women who are not within the age range standardized by this research, ie obese women with SOP or SM, women who use steroids or other drugs that may interfere with metabolism, hyperprolactinemia, hypo / hyperthyroidism, congenital adrenal hyperplasia classical and non-classical Cushing&apos;s disease and tumors of ovary or adrenal secreting androgen women who are pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3fs2dm	Effect of Elastic Bandage on Hip Muscles, Trunk and Leg Movement, and Performance on Functional Testing in Healthy Women	Data analysis completed	Intervention	2018-12-12	<NULL>	<NULL>	2382	Effect of Dynamic Tape Functional Bandage on Gluteus Medius Muscle Function, and in Trunk and Lower Limb Kinematics and Functional Performance in Healthy Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3fs2dm	<NULL>	Female subjects; aged between 18 and 30 years old; belonging to the university community; who agreed to participate in the study; were previously enrolled in a Free and Informed Consent Term.	Presence of pain or signs characteristic of musculoskeletal dysfunction in the lower limbs and vertebral column; history of surgery and  or orthopedic dysfunction in the lower limbs in the last year; presence of cardiovascular or respiratory disease that impeded the performance of the study motions; presence of systemic or vestibular disease that affected the balance; presence of peripheral or central metabolic or neurological disease and; history of allergic reaction to the application of elastic bandages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5ktb2t	Restoration of cavities in the Cervix of the Teeth not Caused by Caries: clinical evaluation	Recruitment completed	Intervention	2018-12-13	<NULL>	<NULL>	2383	Class V Non-Carious Cervical Lesions restorations with bioactive resins: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-16	Instituto de Ciência e Tecnologia - ICT UNESP	Instituto de Ciência e Tecnologia - ICT UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5ktb2t	<NULL>	Be over 18 years of age; Being in good general health, Have an acceptable level of oral hygiene, To present at least 2 non carious cervical lesions in canines or premolars, Tooth vitality (tooth to be restored), antagonist tooth, availability to attend the evaluations	Present allergies to the materials employed, initiate the use of removable prothesis, braces or pregnancy during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5npk9s	Buzzy® and Distraction®: relief of pain in childhood vaccination	Recruitment completed	Intervention	2018-12-13	<NULL>	<NULL>	2384	Use of Buzzy® and Distraction® devices for patient reflief during child vaccination	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5npk9s	<NULL>	Inclusion among children aged two to four years who attended the UBS for vaccination, accompanied by at least one of their legal guardians, were considered eligible for inclusion for injectable immunization recommended by the PNI vaccination schedule for their respective age group.	Participants who took any analgesic in the last six hours were excluded from the sample; have some type of injury or abrasions in the region where the device will be placed; have a history of syncope during procedures involving needle; have a fever; vomiting; lowering of consciousness level; or have some type of deficiency or underlying neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5pdk45	Effects of an exercise program on the realignment of lower limbs of overweight and obese children: a randomized clinical trial	Data analysis completed	Intervention	2018-12-13	<NULL>	<NULL>	2385	Realignment of lower limbs in overweight and obese children: an eight week intervention program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-5pdk45	<NULL>	Being overweight or obese; having between 7 and 9 years of age; returning the Free Consent Form signed by an adult; returning the Assent Form signed; being a student of the José Joaquim da Silva School.	Being present in less than 85% of the sessions; participating in sports activities other than Physical Education classes; being transfered from the school; refusing to perform the exercises in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-6tzs5k	Evaluation of the use of ketamine medication in the treatment of depressed or bipolar people: a study with a control group	Recruiting	Intervention	2018-12-15	<NULL>	<NULL>	2386	Sublingual ketamine in the treatment of Mood Disorders	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Hospital São José	Hospital São José	https://ensaiosclinicos.gov.br/rg/RBR-6tzs5k	<NULL>	Volunteers who have some mood disorder and high risk of suicide; age from 14 to 74 years of age	Volunteers manifesting delusions or manic symptoms upon examination of mental state or by BPRS and / or YOUNG; present substance use disorder with recent use in the last 72 hours (except nicotine and benzodiazepines) or present severe exogenous intoxication; being pregnant or with suspected pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2cyp7c	Effects of the use of colostrum as an oral therapy in very low birth weight preterm infants under the Unified Health System (SUS)	Not yet recruiting	Intervention	2018-12-17	<NULL>	<NULL>	2387	Colostrotherapy, nutrition, pondero-estatural growth and morbimortality of preterm infants of very low weight attended by the Unified Health System (SUS): intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Estadual de Feira de Santana	Hospital Inácia Pinto dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-2cyp7c	<NULL>	Infants admitted to Neonatal Units; birth weight less than or equal to 1500g; less than or equal to 37 gestational weeks; zero diet by oral and enteral route or in total parenteral nutrition; clinically stable; until 24 hours of life.	Referring to the mother: maternal history of substance or drug abuse; presence of psychological disorder; multiple gestation from triplets; contraindications for breastfeeding (retroviruses and cytomegalovirus). Regarding the newborn: use of vasopressor medication greater than 10mcg / kg / min; needing for immediate surgical intervention; presence of syndromes and / or congenital malformations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3s7t6p	Effect of the training of the musculature of the breathing and of the movement in the capacity to carry out activities in people who undergo coronary artery bypass surgery	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2388	Effect of respiratory muscle training on the early functional capacity of individuals after myocardial revascularization surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de Alfenas	Hospital Santa Lúcia de Poços de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-3s7t6p	<NULL>	Volunteers with coronary artery disease; adults between 18 and 80 years; of both sexes.	Volunteers presenting with postoperative complications; with osteomuscular sequelae of stroke; osteomuscular sequelae that compromise the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-48k5jm	Effects of Massage on leg muscles on balance	Recruitment completed	Intervention	2018-05-14	<NULL>	<NULL>	2389	Effects of the Massage application time in the recovery of muscle damage in the hip and knee extensor muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-48k5jm	<NULL>	Young volunteers; men; healthy; physically active; not drug users that affect strength or balance	Volunteers who have musculoskeletal impairment of the lower limbs; volunteers with diseases (labyrinthitis, migraine) that compromise the balance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5rd2hx	Development of a diaphragm footbed for the treatment of wounds on diabetic feet based on a membrane with natural medicine	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2390	Development of a Diabetic Foot Insole Derived from Natural Latex with Tissue Neoform Induction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5rd2hx	<NULL>	Subject of the Regional Hospital of Taguatinga; of both sexes; age from 18 to 75 years; presenting diabetic foot ulcer of neuropathic and / or vascular origin with or without clinical signs of infection; who agree to participate and sign the TCLE (Informed Consent Form); with capacity to provide information about the tests and to collaborate with the project.	Pregnant; patient who drinks alcohol and / or drugs; evidence of osteomyelitis or gangrene somewhere on the affected extremity; topical application at the wound site after the start of the study that were not adopted in this protocol; present discomfort during the treatment application; patients who miss three consecutive times.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-3w6jxn	Simulation in the teaching of nursing diagnoses	Recruiting	Intervention	2018-12-17	<NULL>	<NULL>	2391	A Realistic simulation in the teaching-learning process of the nursing diagnostic reasoning	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-15	Universidade Federal do Rio Grande do Norte- UFRN	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-3w6jxn	<NULL>	"For the students: graduating nursing from UFRN; age equal to or greater than 18 years; attending the 6th period of the course; have studied the disciplines of semiology and semi-technical in nursing, nursing care methods and models and integral health care I.
For the Specialists: to be a member and researcher of the CIPE center; doctor; have research in the area of simulation."	"For students: disciplinary issues; not be able to participate in all stages of the research.
For the Specialists: to be inserted less than 1 year in the CIPE center; do not present an e-mail for correspondence registered in the Lattes Curriculum."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-4shrx2	The effects of cranial electrical stimulation associated with video game training in postural control and the balance of the elderly	Recruiting	Intervention	2018-06-18	<NULL>	<NULL>	2392	The effects of transcranial direct current stimulation (tDCS) associated with virtual reality in postural control and balance of the elderly. Clinical, blind, controlled, randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-4shrx2	<NULL>	Healthy elderly people aged 60 to 80 years; Both genders; Independents for standing and walking with or without auxiliary devices	Elderly with amputation in lower limb or immobilized; Musculoskeletal disorders limiting or restricting the performance of training; Chronic or progressive neurological changes of central or peripheral origin, with motor limitations; Limiting or hindering pain in the execution of the proposed activities;  Visual or auditory changes without use of corrective apparatus; Cognitive deficit, with a score lower than 14 evaluated by the Mini Mental State Examination; Skin changes (pain, open sores, hyperesthesia, anesthesia) or metallic implants in the region of the scalp; Cardiac disorders and respiratory diseases not treated or controlled or that have symptoms of shortness of breath, tachycardia; Be on treatment with chemotherapy or hemodialysis; Use corticosteroids or medicines that limit or lower the level of sleep and wakefulness; Do not agree and sign the Term of Free and Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-7k6v3v	Influence of meal frequency on reduced energy diet in body weight loss, blood sugar, blood fats, ghrelin hormone in the blood and energy expenditure of obese women	Not yet recruiting	Intervention	2018-12-18	<NULL>	<NULL>	2393	Influence of the frequency of meals in the hypocaloric diet in the loss of body weight, glycemia, Serum lipid profile, plasmatics ghrelin and energetic expenditure of obese women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-14	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7k6v3v	<NULL>	Adult women 20 to 59 years of age, obese, with a body mass index (BMI) equal to or greater than 30 kg / m2 (WHO, 1988), of any race or color, not menopausal, who have not changed body weight and who have not diet to lose weight in the last 3 months.	Women will not be included athletes, users of medication or supplements for weight control, smokers, alcoholics, with cardiac complications, clinical diagnosis of diabetes mellitus, pregnant women, infants, illiterates and those with diseases such as cancer, liver diseases and severe nephropathies. Women who do not comply with all the protocol proposed during the intervention or that present intercurrences that interfere with their eligibility during the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-95xwz8	Effect of alpha-lipoic in the control of acute pain and levels of biomarkers in surgery  of femur fracture	Data analysis completed	Intervention	2018-12-18	<NULL>	<NULL>	2394	Effect of alpha-lipoic acid as adjuvant in the control of acute pain and levels of biomarkers in surgery for correction of femur fracture	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Doutor José Frota	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-95xwz8	<NULL>	Patients older than 18 years and less than 65 years of age, of both sexes, with physical status ASA I and ASA II according to the American Society of Anesthesiologists (ASA) Anesthetic Care Guidelines, scheduled for elective surgery in femur fracture correction	Volunteers who were hypersensitive to any of the drugs used in the study, who were pregnant, had kidney disease, coagulation disorder, puncture site infection, clinical signs of hypovolemia, who could not collaborate with the evaluation of postoperative analgesia and users of illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-98wrmb	Evaluation of two chemical coadjuvants in the treatment of chronic periodontitis	Recruitment completed	Intervention	2018-12-18	<NULL>	<NULL>	2395	Comparative evaluation of two chemical gel adjuvants in the treatment of Chronic Periodontitis: 1% Chlorhexidine x 2.5% Melaleuca, a controlled clinical study randomized double blind	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-08-10	Centro Universitário Cesmac	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-98wrmb	<NULL>	Patients systemically healthy, older than 18 years and younger than 60 years of age, able to read and sign the WICF and diagnosed with chronic periodontal disease.	Patients with any pathology that negatively influence tissue healing (eg diabetes mellitus), pregnant and lactating, allergic to adjuvants that are used in the research, and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-786qk7	Electromyographic responses of posture differences through neurosensory stimuli	Data analysis completed	Observational	2018-12-18	<NULL>	<NULL>	2396	Analysis of the influence of visceral manual therapy on upper limb affections	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Católica de Pernambuco	Universidade Católica de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-786qk7	<NULL>	healthy individuals; of both sexes; are not subject to psychological treatment; agreed to participate in the study by signing the informed consent form	individuals who have some type of postural or balance deficit or have disorders of the vestibular system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-33hx6y	Pilates effects on the posture, balance and quality of life of Visually Impaired persons.	Data analysis completed	Intervention	2018-12-18	<NULL>	<NULL>	2397	Effects of a Pilates Mat protocol on the posture, balance and quality of life of the Visually Impaired of the Instito dos Cegos do Brasil Central- ICBC	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-33hx6y	<NULL>	PG – Individuals with visually impairment (Pilates intervention); CG – Individuals with visually impairment (no Pilates intervention); from the age of 18 to 59; both genders.	Individuals with a cognitive deficit; individuals who were reporting in the anamneses hearing or sensory deficiency, pathology in the labyrinth and individuals who were carrying out treatments and / or other physical activities that interference in the muscular force, flexibility and balance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-56qk5j	Influence of electrotherapy in the treatment of swallowing disorders in stroke patients	Recruiting	Intervention	2018-12-18	<NULL>	<NULL>	2398	Randomized study of the influence of Functional Electrostimulation in patients with neurogenic oropharyngeal dysphagia after Ischemic Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-56qk5j	<NULL>	40 a 70 years; clinical diagnosis of ischemic stroke confirmed through medical; oropharyngeal dysphagia after Stroke; use of enteral feeding tube; Glasgow &gt; 11	Degenerative neurological Diseases; neoplasm; pacemaker; cochlear implant; febrile state;pregnancy; anxious patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-8tww4y	Treatment of women with Urinary Incontinence in Primary Care	Data analysis completed	Intervention	2018-12-19	<NULL>	<NULL>	2399	Implementation of Assistance to women with Urinary Incontinence in primary care	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-01	Universidade Federal de Minas Gerais	Prefeitura Municipal de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-8tww4y	<NULL>	Women from the local community; aged 18 years; had never received physiotherapy intervention for pelvic floor dysfunction.	Women who could not contract their PFM; were pregnant; presented symptoms of urinary infection; neurological disorders and/or difficulty understanding the treatment protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-5p8qtf	Analysis of the capacity of detection of carotid artery calcification through a new dental examination, comparing with the medical examination used	Recruitment completed	Intervention	2018-12-19	<NULL>	<NULL>	2400	Analysis of the Accuracy of Panoramic Radiography associated with the Anteroposterior Towne Technique of Modified Towne in the detection of Calcified Ateromas - comparison with Doppler Ultrasonography	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5p8qtf	<NULL>	Patients with prior indication of Panoramic Radiography for dental treatment; with Doppler Ultrasonography of the bilateral carotid systems for cardiac monitoring purposes in less than 12 months; between 50 and 90 years.	Patients who presented difficulties in ambulation; Patients with disabling conditions that could hinder their participation; with cognitive deficit, who did not agree with the Terms of Free and Informed Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-2crd42	Effect of electrical stimulation on the scalp associated with exercise in the ability to perform day-to-day movements of elderly individuals	Recruiting	Intervention	2018-07-20	<NULL>	<NULL>	2401	Effect of transcranial direct current stimulation (tDCS) and multicomponent training on the functional capacity of elderly individuals - clinical, controlled, randomized, double blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2crd42	<NULL>	The elderly should be between 60 and 80 years old; accept the terms of the study; both genders; be independent for standing and walking with or without auxiliary devices; to be hemodynamically stable according to the Brazilian Society of Cardiology guidelines lower than the blood pressure of 140mmhg by 90mmhg	Amputation in lower limb or immobilized; musculoskeletal changes that may limit or restrict the performance of training; chronic or progressive neurological changes of central or peripheral origin with motor limitations; limiting or making it impossible to carry out the proposed activities; diagnosis of acute coronary syndrome or patients with severe cardiac events greater than 4 indicated by the functional classification of the new york heart association; pulmonary diseases as chronic obstructive disease; asthma; cystic fibrosis and interstitial lung disease; positive cut-off point for cognitive deficit screening by mini mental status examination with a score lower than 11; visual or auditory deficits or without use of corrective apparatus; heart pacemaker; contraindications to the use of transcranial direct current stimulation; history of seizure or recurrent epilepsy; brain tumors; metallic materials near the stimulus site; infection or skin lesion at the site of stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-76vccv	Association of Laser and Microneedling in Female Baldness.	Not yet recruiting	Intervention	2018-12-20	<NULL>	<NULL>	2402	Association Fotobiomodulation and Microagulhamento Hair Loss in Female Pattern (FPHL): clinical study, randomized, double-blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-76vccv	<NULL>	This study will be conducted in women; aged between 18 and 60 years; who present the female capillary fall; telogen effluvium profile; and androgenetic alopecia; Women with capillary rarefaction; Great hair loss in the last five years; gradually in the last year; they are able to perform no chemical procedure for the period of 3 months.	Scalp scarring; wear wigs; use appliqués that cause weight on the stem; use drugs continuously as anti-inflammatories; anxiolytics; antifungals; hormonal inhibitors; Have fungal or inflammatory conditions; women undergoing hormonal gynecological treatment; Uncontrolled chronic diseases such as Arterial Hypertension; diabetes; Participants unable to understand and sign the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-97q9vc	Evaluation of broken teeth with silver amalgam restoration in relation to restoration size	Recruiting	Observational	2018-06-26	<NULL>	<NULL>	2403	Evaluation of restored teeth with amalgam and fractured teeth considering the extension of the restoration	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-97q9vc	<NULL>	Be at least 18 years; Present good general health; Do not present active caries on the selected tooth; Do not stress periodontal disease on the selected tooth; To present restoration of silver amalgam with fractured tooth - case group and non-fractured - control group; Present the opposing and adjacent tooth; The teeth must have vital pulp	Medical condition that may interfere with the safety of the volunteer during the study period, or allergic reactions to substances and / or products that will be used to restore fractured teeth; Use of removable prostheses which have the clamps resting on the teeth used for the research; Patients with intense parafunctional habits, determined by excessive tooth wear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-7vgnk2	Low intensity laser therapy associated with Chamomile and Calendula in the treatment of oral Mucositis	Not yet recruiting	Intervention	2018-12-26	<NULL>	<NULL>	2404	Low intensity laser associated with matricaria recutita linn and calendula officinalis in the treatment of oral Mucositis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Fundação Valeparaibana de Ensino	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7vgnk2	<NULL>	Age between 19 and 30 years; presence of oral mucositis grade; patients receiving similar treatment protocols; patients able to cooperate with the protocol established by the research; patients capable of performing the oral hygiene protocol; patients who accept the terms proposed in this study and sign the informed consent form.	Patients who present some allergic reaction to any of the plants used in this study, or have a history of any adverse reaction to the family Asteraceae or Compositae, will be excluded; Receiving oral or intravenous anticoagulant therapy; Use topical or systemic therapy with anti-inflammatories; receive another type of standard or experimental protocol for the treatment of oral mucositis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-3vm7bf	Isokinetic Exercise in Parkinsonians	Recruitment completed	Intervention	2018-12-26	<NULL>	<NULL>	2405	Isokinetic muscle training in patients with Parkinson&apos;s Disease: influence on the gait, balance and plasma measures of oxidatives parameters	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-3vm7bf	<NULL>	Idiopathic PD diagnosed by a neurologist physician according to the CBCL, aged 50 to 72 years, stage II and / or III, according to the Hoehn and Yahr scale; Individuals who do not present with dementia verified by the ACE-R scale; Ability to wander and stand independently and safely.	"Individuals with PD who do not follow the prescription regarding the established medicines; 
Persons with PD who are in the practice of regular physical activity in the 02 months before the beginning of the study and those who have a physical activity time of more than 06 months; 
To present osteomioarticular, neurological and cardiovascular conditions, among other conditions that present medical contraindication for the practice of training that involves strength; 
Extreme obesity (&gt; 40); 
Uncontrolled hypertension (&gt; 150/90 mmHg); 
Have suffered a myocardial infarction in the last 12 months or have a cardiac pacemaker; 
Have suffered a fracture or muscle injury in the last 12 months; 
Have undergone total or partial knee arthroplasty or osteosynthesis of any nature; 
Those who present 2 consecutive absences or 03 in the total of the proposed treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-36y8cw	The effect of vitamin A in patients with sinusitis with nasal polyps	Recruitment completed	Intervention	2018-12-26	<NULL>	<NULL>	2406	"A prospective open-label randomized trial of tretinoin in patients with 
chronic rhinosinusitis with nasal polyps"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-07-25	Hospital das Clínicas da UNICAMP/Faculdade de Ciências Médicas.	Hospital das Clínicas da UNICAMP/Faculdade de Ciências Médicas.	https://ensaiosclinicos.gov.br/rg/RBR-36y8cw	<NULL>	Patient with chronic rhinosinusitis with bilateral nasal polyps; with or without allergy; with or without asthma; from any gender; older than 18 years old.	Patients younger than 18 years; women of childbearing or non-sterilized age; current or previous use of isotretinoin; history of nasal surgery for less than 5 years; non-controlled diabetic patients or poorly controlled hepatopathies and nephropathies; patients with cystic fibrosis or mucociliary diseases; presence of larger nasal tumors or malformations; cocaine or other inhaled drug user; patients with primary or secondary immunodeficiencies, coagulopathies, blood dysplasias, systemic or granulomatous vasculitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-54kjdc	Use of Bromelain in the treatment od pain and swelling on impacted third molar Surgery	Recruitment completed	Intervention	2018-12-27	<NULL>	<NULL>	2407	Use of Bromelain in the control of pain, oedema and trismus om impacted third molar Surgery	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-02	Faculdade de Odontologia de Pernambuco	Faculdade de Odontologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-54kjdc	<NULL>	Healthy patients, between 18 and 40 years old, with indications of bilaterally lower third molars surgery and with the same degree of difficulty for removal.	Patients with any systemic disease or overweight were excluded from the study; smoking; patients who have taken any medication or anti-inflammatory drugs in the last two weeks; patients who do not attend all return visits; allergic to Dipyrone or bromelain derivatives; history of pericoronitis, and patients with absence of upper and / or lower incisors due to the impossibility of measuring the oral opening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-5gf7kx	Laboratory and clinical study of implants of reduced diameter	Recruiting	Intervention	2018-12-27	<NULL>	<NULL>	2408	Biomechanical behavior of ultra-narrow diameter implants	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-07	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5gf7kx	<NULL>	"Good systemic health or clinically compensated (proven by means of medical certificate) that allows surgical procedures. Conditions whose reports or signs should be absent during anamnesis and clinical examination include uncontrolled diabetes mellitus and severe cardiovascular disease;
Accept the stabilization of their total superior dentures by means of two implants, after clarifying the information during the initial consultation (Over Group);
Patients with absence of one or more elements in areas of low occlusal load (upper lateral incisors and lower incisors) for the Uni Group;
Present adequate space in the anterior maxilla for the installation of 2 narrow implants, without the need of grafting, evaluated by clinical and radiographic examination (Over Group) and adequate space in the maxilla or mandible for the installation of 1 or more unit implants ( Uni Group);
be able to maintain adequate oral hygiene and sanitize their prostheses;
Free edge of pathologies in soft tissue and bone;
Adequately understand Portuguese, both spoken and written;
be able to provide free and informed consent."	"Pathological alterations of the alveolar borders;
Acute or chronic symptoms of disorders due to parafunction;
History of radiotherapy in the orofacial region;
Specific conditions such as alcoholism, smoking (a maximum limited number of 10 cigarettes / day was accepted);
Cognitive motor disorders;
debilitating / severe systemic diseases requiring frequent hospitalization;
Patients who do not fit into any standard of inclusion criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-8df2h4	Acupuncture treatment in elderly people with loss of muscle mass: effects on the strenght and inflammatory mediators	Data analysis completed	Intervention	2018-12-27	<NULL>	<NULL>	2409	Effects of acupuncture on the muscular strength of elderly patients with sarcopenia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-14	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8df2h4	<NULL>	male and female seniors; sedentary; who were not under acunpuncture treatment during the survey period.	Individuals who were afraid of needles; with mobility problems that prevented them to attend the data collection and processing location; who presented difficulties of understanding the treatment and the applied tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-3x9m5j	Influence of Exposure of Vital Teeth To Red Wine During at Home Tooth Bleaching: Clinical Study.	Recruitment completed	Intervention	2018-12-27	<NULL>	<NULL>	2410	Clinical evaluation of red wine exposure after bleaching of vital teeth	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Centro Universitário do Maranhão	Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3x9m5j	<NULL>	Individuals with good oral health; with all upper anterior teeth (canines and incisors) and with vitality; free of caries lesions and previous restorations; good oral hygiene; without cervical lesions (abrasion, erosion and abfraction); absence of periodontal disease; non-smokers. The initial color of the teeth should be A2 or darker compared to the Vita Classica scale.	Individuals submitted to any type of previous bleaching procedure; presenting carious lesions; non-carious cervical lesions; pregnant or lactating; patients with teeth presenting with intrinsic factors (tetracycline, fluorosis, hyperplasia); endodontic treatment; presence of anterior superiors restorations (canines and incisors); patients who report gingival retraction; dental sensitivity or parafunctional habits; patients who have previous dental prostheses; or those who are taking medications containing heavy metals; analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-37wrrs	The influence of counseling on the duration of exclusive breastfeeding	Not yet recruiting	Intervention	2018-12-27	<NULL>	<NULL>	2411	Breastfeeding counseling at home: the impact on exclusive breastfeeding	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-37wrrs	<NULL>	"GESTANT: That intends to breastfeed; That you accept to participate in the research in prenatal and later in the puerperium. 
PUERPERA AND NEWBORN: Puerper who participated in the research since the gestation; That the delivery occurred with Gestational Age (GI) equal to or greater than 37 weeks; Newborn with birth weight equal to or greater than 2,500 g."	PREGNANT: Multiple gestation; Child donation plans; Mental restrictions that make it impossible to understand the instrument; Important clinical settings in which breastfeeding is contraindicated (HIV, HTLV, use of illicit narcotic substances, etc.). PUERPERA AND NEWBORN: Change of residence of the area of coverage of the Family Health Strategy that belonged to the gestation; Childbirth and / or postpartum with important obstetric complications that make breastfeeding difficult (severe hemorrhage, etc.); Congenital malformations of newborns that may contraindicate or complicate breastfeeding; newborn sent to the Neonatal Intermediate Care Unit, Neonatal Intensive Care Unit, or equivalent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-95smwv	Social Support	Other	Intervention	2018-12-27	<NULL>	<NULL>	2412	Analysis of the independent effect of social support on adherence and success rates of tuberculosis treatment in Brazilian capitals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-21	Conselho Nacional de Pesquisas	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-95smwv	<NULL>	"Patients over 18 years of age, being diagnosed
  with tuberculosis."	Individuals with multidrug-resistant tuberculosis, transferred from other health facilities for more than 15 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9kj5nk	Acupuncture in the improvement of Inflammation of the gums in women with Diabetes	Recruitment completed	Intervention	2018-12-27	<NULL>	<NULL>	2413	Acupuncture in the improvement of Gengivite in women with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal do Piaui UFPI	Universidade Federal do Piaui UFPI	https://ensaiosclinicos.gov.br/rg/RBR-9kj5nk	<NULL>	Diabetic women who presented gingivitis after evaluation of the Gingival Bleeding Index.	Diabetic patients with healthy gingiva and diabetic patients with edentulous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-3fw9xf	Physical activity in Breast Cancer survivors: effects on physical capacity and quality of life	Recruiting	Intervention	2018-12-27	<NULL>	<NULL>	2414	Effects of different physical activity modalities on aerobic fitness, muscle strength and quality of life in Breast Cancer survivors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-26	Escola de Educação Física e Esporte da Universidade de São Paulo	Fundação Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-3fw9xf	<NULL>	Women’s volunteers; age between 35 and 75 years; from the Instituto do Câncer do Estado de São Paulo (ICESP) rehabilitation program, offered to the patients that complete breast cancer therapy; that had finished all cancer treatments.	Volunteers with metastatic disease; severe lymphoedema; obesity; organic dysfunctions (renal insufficiency, cardiac insufficiency and chronic liver disease); risk factors not controlled (hypercholesterolemia, diabetes, hypertension); alterations in the exercise test that contraindicate the practice of moderate physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9psmr5	Woman&apos;s mental health in pregnancy and postpartum	Recruiting	Observational	2018-12-27	<NULL>	<NULL>	2415	Peripartum Mood Disorders: Screening and Risk factors	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Hospital de Clínicas Universidade Federal do Paraná	Hospital de Clínicas Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9psmr5	<NULL>	Brazilians pregnant woman between 18 and 45 years, having prenatal consults in  Complexo do Hospital de Clínicas da Universidade Federal do Paraná, by any indication, between 18 and 24 weeks of gestational age.	Patients that refuse to participate of the study or that are not able to answer the questionnaires 40-60 days after delivery, or that refuse collecting a blood sample to evaluate serum levels of estradiol and progesterone or patients in drug treatment fot any type of mood disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-85hvqq	The impact of physical exercise on inflammatory markers and functional capacity in people with chronic respiratory disease	Recruiting	Intervention	2018-12-27	<NULL>	<NULL>	2416	The impact of pulmonary rehabilitation on inflammatory markers and functional capacity in patients with bronchiectasis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-85hvqq	<NULL>	Patients of both gender with clinical diagnosis of bronchiectasis, with moderate or severe according with the FACED score: age between 18 and 80 years, clinically stable (without hospitalizations or infections in the last three months of the study beginning).	Patients who presented other respiratory chronic disease associated that needed treatment or urgent intervention; other disabling diseases, severe or with difficult control; patients who did not finished the study protocol and/or those who presented exacerbations during the period of their participation in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-2f5msy	Gummy smile treatment : surgical and with the use of botulinic toxin	Recruiting	Intervention	2018-12-29	<NULL>	<NULL>	2417	Use of Botulinic Toxin and Repositioning Lip Surgery - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-10	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-2f5msy	<NULL>	Adults with age range from 18 - 50 years;  Excessive gingival display more than 3 mm during smiling; Patients having hypermobile upper lip with or without other causes of gummy smile; Normal lip separation (ILG) at rest; Medically health	Patients under 18 years; Smoking Patients; Pregnant or lactating female patients; Patients with systemic diseases or neuromuscular disorders; Gummy smile with gingival display less than 2 mm ; Patients with periodontal disease or gingival hyperplasia; Patients with cause is not hipermobility of lip; Short lip	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9fp769	Relationship between patient safety and burnout syndrome	Recruiting	Observational	2018-12-29	<NULL>	<NULL>	2418	Relation between patient safety culture and burnout syndrome in pediatric hospitals	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-18	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-9fp769	<NULL>	Health professionals; pediatric sectors; minimum of six months in the service	Administrative sector; removals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-3z5tbf	Clinical evaluation of restorations performed on tooth and outside the mouth using flexible die technique	Data analysis completed	Intervention	2019-01-01	<NULL>	<NULL>	2419	Clinical evaluation of direct and semidirect restorations using flexible die technique	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-07	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-3z5tbf	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-7pkj3q	Non Invasive Ventilation during Aerobic Exercise in patients with Heart Failure	Recruiting	Intervention	2019-01-03	<NULL>	<NULL>	2420	Effects of an Exercise Program performed with Non Invasive Positive Pressure Ventilation support in Hospitalized Patients with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-02	Instituto Nacional de Cardiologia	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-7pkj3q	<NULL>	Diagnosis of heart failure; age greater than 18 years; both sexes; functional classification by NYHA I, II III or IV; hospitalization for decompensated HF	Decompensated lung diseases; pregnancy; head trauma; brain injury; malignant arrhythmias; hemodynamic instability; acute coronary syndrome; inability to participate in physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9y8kjq	Effects of Functional and Traditional Training on indicators of physical fitness, quality of life and cardiovascular health in the elderly	Recruitment completed	Intervention	2019-01-03	<NULL>	<NULL>	2421	Functional Training versus Traditional Strength Training: Effects on indicators of physical fitness, quality of life and cardiovascular health in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9y8kjq	<NULL>	Be physically independent; be 60 years or older; do not present dysfunctions that restrict the practice of physical exercises; not to use hormone therapy medications, lipid-lowering agents, hypoglycemic agents and anti-inflammatories; not be involved in regular physical activity / exercise programs (two or more times / week) for at least six months prior to the start of the study	To present resting blood pressure above 160/100 mmHg; history of anemia, cerebrovascular disease, acute myocardial infarction, orthopedic disorders that impede joint movement; deep venous thrombosis and cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-2x2ntz	Evaluation of control of signs and symptoms of inflammation after third molar extraction	Data analysis completed	Intervention	2019-01-04	<NULL>	<NULL>	2422	"Evaluation of pain control, edema and trismus after third molar extraction
through two pharmacological regimens"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2x2ntz	<NULL>	"age between 18 and 35 years;
no systemic disease (ASA I);
not to use medications currently or in the previous week of the research;
To present the lower third molars in similar positions with similar patterns of root formation;
do not present allergy to the drugs used in the study;
To present surgical site without current signs and symptoms of infection"	"patients with a history of pregnancy or lactation; history of gastrointestinal bleeding or peptic ulcer;
allergy to aspirin or NSAIDS;
liver, kidney, haematological and central nervous system diseases;
continued use of psychoactive drugs, analgesics, steroidal and non-steroidal anti-inflammatory drugs and
smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-9t6jgv	Natural medicine made from black pickle and saffron as an alternative treatment for actinic cheilitis	Recruiting	Intervention	2019-01-04	<NULL>	<NULL>	2423	Phytotherapy formulation containing bidens pilosa and curcuma longa extract as an alternative therapy for actinic cheilitis treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-11	Faculdade de Odontologia - Universidade Federal de Goiás	Faculdade de Odontologia - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9t6jgv	<NULL>	Patients with actinic cheilitis lesions who can cooperate and who agreed to participate in the study signed the free informed consent form	Patients who don´t agreed to participate in the study signed the free informed consent form;  allergic to any component of the formulation; immunocompromised patients and those exhibiting ulcerated areas, nodularity, and bleeding in the lip that could suggest progression of SCC; and patients using medications in the target area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4gfk87	Impact of Vicryl Plus to prevent infection of leg  in the operations of Safena Bypasses.	Recruitment completed	Intervention	2019-01-07	<NULL>	<NULL>	2424	Effect of using Triclosan-impregnated Polyglactin suture to prevent infection of saphenectomy wounds in Coronary Artery Bypass Grafting surgery: a prospective, double-blind, randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-22	Instituto Nacional de Cardiologia	Johnson	https://ensaiosclinicos.gov.br/rg/RBR-4gfk87	<NULL>	Volunteers with indication of myocardial revascularization, with or without extracorporeal circulation; of both sexes, with age above 30 years	Emergency surgeries; other cardiovascular surgery; antibiotic therapy for prior infectious disease, up to one month prior; immunosuppressed patient, defined in this study as a patient with AIDS, neoplasia or use of corticoid; patients requiring carotid artery surgery; bi-laterally saponectomized; severe peripheral vascular disease; venous disease of the deep system of infertile limbs; superficial saphenous vein thrombophlebitis; psychiatric disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-5t9hp5	Influence of Multicomponent Training on Functional Capacity, Cognition and Body Composition in Physically Active Elderly Women	Recruiting	Intervention	2019-01-07	<NULL>	<NULL>	2425	Functional Training vs Traditional Training: Effect on functional capacity, cognition and body composition in physically active elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-21	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5t9hp5	<NULL>	Be over 60 years of age and; Do not present any joint or cardiac instability that indicates the performance of the training.	Regular participation in systematic exercise programs in the three months prior to the present study; Presence of uncontrolled cardiovascular and musculoskeletal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-7tvhq8	Actions to prevent pain and injury in the nipple during breastfeeding.	Recruiting	Intervention	2019-01-07	<NULL>	<NULL>	2426	Comparative study of an intervention for the prevention of pain and nipple trauma in breastfeeding.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7tvhq8	<NULL>	Have a desire to breastfeed; Be in prenatal care; Have gestational age between 35 and 37 weeks, calculated from the date of the last menstrual period or first trimester ultrasonography; Be 18 years of age or older; Have a fixed or mobile phone, for contact.	Anatomical alterations of the nipples that favor nipple trauma (inverted nipple, pseudoinverted); Residence outside the municipality of Goiânia - GO; Do not adhere to the proposed protocol on 4 consecutive days, or use another concomitant intervention; To present adverse effects to the proposed intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-8ybbm9	Evaluation of the use of isotonic serum in patients admitted to Pediatric Intensive Care	Recruitment completed	Intervention	2019-01-07	<NULL>	<NULL>	2427	Evaluation of the use of isotonic serum in patients admitted to Pediatric Intensive Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-04	Complexo Hospital de Clínicas Universidade Federal do Paraná	Complexo Hospital de Clínicas Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8ybbm9	<NULL>	Patients of both sexes admitted to the Pediatric Intensive Care Unit of the Hospital de Clínicas Complex of the Federal University of Paraná, Brazil who signed a free and informed consent form, were included.	Patients with dialysis renal insufficiency; diabetic ketoacidosis; sickle cell anemia; hypernatremia with sodium above 170mEq / L; patients who did not require a basic maintenance plan or who remained less than 24 hours in the Pediatric Intensive Care unit were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-9d94td	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity	Data analysis completed	Intervention	2019-01-07	<NULL>	<NULL>	2428	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity: A Randomized Controlled Trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-05	Universidade Estadual do Rio de Janeiro	Universidade do Porto	https://ensaiosclinicos.gov.br/rg/RBR-9d94td	<NULL>	Children and adolescents between 9 and 12 years of age are either eutrophic or overweight or obese.	Kidney disease. Hematologic disease. Liver disease. Rheumatological disease. Neurological disease. Cardiovascular disease. Respiratory disease. Infectious disease. Endocrine disease. Any type of health condition that may interfere in the evaluation of outcomes as well as contraindicate the practice of sports. Regular use of medications mainly for weight control. Participation in weight control programs through diet or exercise in up to six months before the start of the experiment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-5f5jhz	Hand Force and Maximum Bite Force in individuals with and without teeth	Recruitment completed	Intervention	2019-01-07	<NULL>	<NULL>	2429	Manual Grip Strength and Maximum Bite Force in dentulous and edentulous individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Universidade estadual Paulista Júlio de Mesquita filho	Universidade estadual Paulista Júlio de Mesquita filho	https://ensaiosclinicos.gov.br/rg/RBR-5f5jhz	<NULL>	Young women aged between 18-25 years and adults women aged between 39-59 years with the presence of natural dentition that could contain composite resin/amalgam restorations; but without fixed prosthesis in the first molars on both sides; complete edentulous adults women aged between 39-59 years; bimaxillary complete denture wearers with normal alveolar ridges; satisfactory complete dentures	Mandibular resorbed ridge patients; signs/symptoms of temporomandibular disorders; systemic or local disorders; use of medications that may interfere in muscle activity; disorders or diseases of the musculoskeletal-ligament system; rheumatoid arthritis; bimaxillary complete dentures ill-fitting and in unfavorable conditions; patients who are not in the period of adaptation with complete dentures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-7hk8n3	Combination of reduced doses of naltrexone and cranial electrical stimulation in fibromyalgia: randomized clinical trial, blind, controlled with placebo	Recruiting	Intervention	2019-01-08	<NULL>	<NULL>	2430	Association of low doses of Naltrexone and Transcranial Electrical Stimulation in Fibromyalgia: randomized clinical trial, blind, controlled with placebo	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade La Salle	Universidade La Salle	https://ensaiosclinicos.gov.br/rg/RBR-7hk8n3	<NULL>	Provide an informed consent to participate on the study; women with age between 18 and 65 years; medical diagnoses of fibromyalgia according to the American College of Rheumatology criterion (2010); know how to read and write; pain evaluated as bigger than six at the last 3 months on the Visual Analogic Scale; treatment of chronic use stable on the last 3 months;	Be using opioid drugs; pregnancy or non-use of contraceptive method; history of alcohol or drugs abuse on the last 6 months; historic of neurologic pathology; history of cardiac arrhythmia and use of drugs that change the vascular answer (adrenergic blockers, vasodilators); history of cranial traumatism moderated or severe; history of neurosurgery; systemic decompensated disease, and chronic inflammatory disease (Lupus, rheumatoid arthritis, Sjogren Syndrome, Reiter Syndrome);  history of hypothyroidism non compensated; personal history of cancer, passed or in treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-5y5sm9	Fatigue treatment in multiple sclerosis patients	Recruiting	Intervention	2019-01-08	<NULL>	<NULL>	2431	Placebo-controled, randomized clinical trial to assess the active drug response (beta-2 adrenergic agonist) in the treatment of fatigue in patients with Multiple Sclerosis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-11-05	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5y5sm9	<NULL>	Diagnosis of Multiple Sclerosis (according to McDonald&apos;s 2010 criteria); age between 18 and 70 years old; Expanded Disability Status Scale score (EDSS) up to 5.5; fatigue confirmed by Neurological Fatigue Index for Multiple Sclerosis validated for Brazil (NFI-MS/BR) and Fatigue Severity Scale (FSS)	Multiple sclerosis relapse within 30 days prior to the study; poorly controlled hypothyroidism despite of treatment; any tachyarrhythmia identified on the electrocardiogram (ECG); decompensation of chronic systemic or psychiatric diseases (such as arterial hypertension, renal and hepatic impairment, and diabetes); pregnancy or lactation; not signing the consent term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-97g48p	Orange juice and blood Orange juice intake to assess inflammation among tobacco smokers.	Recruiting	Intervention	2019-01-08	<NULL>	<NULL>	2432	Analysis of the inflammatory response and microRNAs expression of smoker patients after orange juice and orange juice with anthocyanins intake	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-06	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-97g48p	<NULL>	over 18 years old; both sexes; tobacco smokers	use of nutritional supplements;use of corticosteroids; presence of respiratory diseases; presence of diabetes melittus II, obesity; dyslipidemia; câncer; heart failure; kidney and/or liver diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-22z3jy	Evaluation of the treatment with blood cells in patients with Behçet Disease	Data analysis completed	Intervention	2019-01-08	<NULL>	<NULL>	2433	Evaluation of the action of the treatment with platelet rich plasma in patients with Behçet Disease	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-22z3jy	<NULL>	Confirmed diagnosis of Behçet disease according to established criteria according International Study Group for Behçet Disease (ISGBD); Minimum recurrence of three episodes of disease activity in the last year; presence of oral/genital ulcers, without corticosteroid use or at most with 10 mg daily (prednisone).	The exclusion criteria were: involvement of the central nervous system and/or ocular picture in activity, hematological or renal alterations; antecedent of Neoplasia in the last 5 year; use of corticosteroids in daily doses above 10 mg and use of anticoagulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-53rgg2	Effects of strength exercises for anterior knee pain.	Recruiting	Intervention	2019-01-10	<NULL>	<NULL>	2434	Effectiveness of a resistance exercise program and neuromuscular training for patients with Patellofemoral Pain Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-10	Instituto de Pesquisa e Ensino do Hospital HOME	Centro Universitário de Brasília - UniCEUB	https://ensaiosclinicos.gov.br/rg/RBR-53rgg2	<NULL>	Will be submitted in the study women with anterior pain in the knee and around the patellofemoral joint; Pain reported on at least two of the following criteria: when going up and down stairs, crouch, jump, after long sitting periods, cracking or crackling, palpation pain, report pain lasting at least two months, report a maximum of 86 points on the scale anterior pain in the knee (maximum = 100 points) and pain at least three in the numerical scale of pain.	Women with any possible degenerative changes of the knee and hip, age between 18 and 45 years, subjects with previous knee and hip surgery, history of patellar dislocation, clinical evidence of knee instability, meniscal or intraarticular lesions, evidence of edema, osgood-schlatter or sinding-larsen-johanssen, patellar tendinopathy, muscular lesions, low back or sacroiliac pain and limb length difference greater than 1cm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-2ssg4w	Physical therapy for visually impaired people	Data analysis completed	Intervention	2019-01-10	<NULL>	<NULL>	2435	Physical therapy in visual impairment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-2ssg4w	<NULL>	Blind individual or individual with low vision; age between 18 and 59 years; cognitive autonomy assessed by the cut-off points of the Mini-Mental State Examination; and no neurological, cardiac or disabling musculoskeletal diseases.	Missing three or more consecutive sessions of physiotherapy and/or missing five sessions during the period of the protocol execution. Furthermore, participants who clearly had difficulties understanding the questionnaire at some point of the study were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-75kj6t	Study about the religiosity and quality of life in hypertensive people.	Data analysis completed	Observational	2019-01-10	<NULL>	<NULL>	2436	Perception of PSF Health Professionals regarding spiritual care from users	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-04-15	Centro Universitária Adventista de São Paulo	Centro Universitária Adventista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75kj6t	<NULL>	Be enrolled in the Basic Health Unit; be over 18 years old; have no other diseases besides hypertension.	Have cognitive deficit; have diabetes; not be enrolled in the Primary Health Care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-5k7pnr	Evaluation of the caracteristics of patients with spinal tuberculosis  in a  hospital in the city of São Paulo.	Not yet recruiting	Observational	2019-01-11	<NULL>	<NULL>	2437	Evaluation of the clinical and epidemiological profile of Tuberculous Spondylodiscitis in a quaternary hospital in the city of São Paulo.	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Irmandade da Santa Casa de Misericórida de São Paulo	Irmandade da Santa Casa de Misericórida de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5k7pnr	<NULL>	Both genders; age: 1 day of life up to 100 years; diagnosis of tuberculosis of the spine. Diagnosis will be defined by: isolation of the etiological agent or by clinical and radiographic criteria characteristic of tuberculosis vertebral involvement and or pathological examination compatible with tuberculosis and / or positive therapeutic test. Isolation of the agent will be considered the presence of BAAR by the Ziehl-Neelsen method, molecular rapid test (real-time PCR) and culture for mycobacteria. The radiographic findings are visualized in radiographs of the spine according to the affected level, in the posteroanterior and profile incidences, with the following findings: aneurysmal abscess, sacral lesions, disc space reduction, vertebral collapse, kyphosis, calcification. The findings found on computed tomography are a decrease in the height of the vertebral body, osteolysis in the terminal plates of the vertebral bodies adjacent to the disc, pre-vertebral abscess, paravertebral abscess. Magnetic resonance imaging findings are hyposignal of the affected disc in weighted images at t1; hypersignal of the disc and the vertebral plateaus adjacent to the disc in t2-weighted images; epidural involvement; paraespinal abscess with a smooth abscess wall. Clinical Criteria: Indolent chronic infection associated with leukocytosis and changes in inflammatory tests, CRP and HSV, associated or not with the positive tuberculin test; Anatomopathological examination: The presence of epithelioid macrophage proliferation constituting confluent granulomas with presence of giant Langerhans cells with central foci of caseous necrosis and surrounding lymphocytic infiltrate was considered a characteristic of TB, with positive BAAR using the Ziehl-Neelsen method . The samples were submitted to routine methods for optical microscopy: 10% formaldehyde fixation, paraffin blocks cut into a 3 micron thick microtome and stained by hematoxylin-eosin (HE), Grocott (for fungi research) and Ziehl-Neelsen (for the BAAR survey). The biopsies were processed according to routine of the laboratory of Pathological Anatomy;	Do not meet the criteria for definition of tuberculo spondylodiscites case; incomplete Medical Record; incomplete image checks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-6q54t4	The effect of exercise training in patients with cardiac fibrosis with functional class II and III	Recruitment completed	Intervention	2019-01-08	<NULL>	<NULL>	2438	Cardiovascular Rehabilitation in patients after Endomyocardial fibrosis cirgury with heart failure in functional class II and III	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Instituto do Coração	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6q54t4	<NULL>	Patients with univentricle or biventricle endomyocardial fibroses; Endocardial resection surgery longer than 6 months, with or without atrioventricular valve replacement; Left ventricle ejection fraction higher than 50 percent; Functional class II or III, NYHA; and Being compensated with optimal medication.	Regular exercise training; History of artery diseases; Diabetes; Pacemakers; Obesity defined as body mass index higher than 30 kg/m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-3pf767	Stem cells for regeneration of bone tissue.	Recruitment completed	Intervention	2019-01-11	<NULL>	<NULL>	2439	Bone tissue bioengineering using stem cells.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Hospital Sírio-Libanês	Hospital Municipal Infantil Menino Jesus	https://ensaiosclinicos.gov.br/rg/RBR-3pf767	<NULL>	"20 patients with unilateral alveolar cleft defects, aged 8 to 12 years, were selected at the Cleft Lip and Palate Unit of the Hospital Municipal Infantil Menino Jesus.
All patients underwent preoperative orthodontic expansion of maxillary segments."	Previous alveolar surgery, previous eruption of the canine or incomplete records.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4bdrc9	Evaluation of microbial contamination of aesthetic orthodontic ligatures by using a molecular biology technique	Data analysis completed	Intervention	2019-01-11	<NULL>	<NULL>	2440	Microbial contamination profile on aesthetic elastomeric ligatures through the checkerboard DNA-DNA hybridization technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-02	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4bdrc9	<NULL>	Patients with good general and dental health; aged between 11 and 25 years; in orthodontic treatment and without having used mouthwashes in the last 3 months	Patients with some type of systemic disease; with poor dental health as presence of dental caries, periodontal disease; or who regularly use mouthwashes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4bghjg	Chewing Gum for Caries Treatment	Recruiting	Intervention	2019-01-14	<NULL>	<NULL>	2441	Evaluation of the Use of a Chewing Gum containing Natural Products on the Salivary Concentrations of Streptococcus mutans in Childrens	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4bghjg	<NULL>	"Children of both sexes;
No history of allergic reactions;
Aged between 5 and 12 years;
With normal pattern of growth and development;
Patients who have not undergone dental treatment during the last six months;
Children with caries (presence of at least one lesion of active caries, cavitated or not cavitated)."	"Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis);
Patients with a history of allergies to medicines, foods or other factors;
Patients with a history of chronic diseases, congenital or any systemic alterations;
Patients with a history of gastrointestinal, hepatic or renal disease;
Patients who have undergone antibiotic treatment up to six months prior to the survey;
Patients with soft tissue lesions in the oral cavity;
Patients whose parents or legal guardians refuse to sign the free and informed consent form;
Children free of carious lesions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-477nbz	Movement Control of Hand in children and adolescents living in Shelter	Recruitment completed	Intervention	2019-01-14	<NULL>	<NULL>	2442	Motor Control Manual in children and adolescents Institutionalized in Shelter	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-477nbz	<NULL>	Children and adolescents from 6 to 18 years; both sexes; institutionalized and not institutionalized in shelter; signature of the consent term; signature of the assent term.	Physical disabilities; visual impairment; hearing deficiency; cognitive deficit; neurological deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4sspn6	The use of Breast Milk compared to Glucose to reduce Pain during Collection of Examination in preterm infants	Data analysis completed	Intervention	2017-08-15	<NULL>	<NULL>	2443	Analgesic effect of Maternal Milk versus 25% Glucose during the collection of Arterial Blood Gases in preterm newborns: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Maternidade Escola Assis Chateaubriand-MEAC	Maternidade Escola Assis Chateaubriand-MEAC	https://ensaiosclinicos.gov.br/rg/RBR-4sspn6	<NULL>	All clinically stable preterm NBs were considered eligible; Regardless of gestational age (GI); Weight greater than or equal to 500 g and with a minimum; 12 hours of life and hospitalized in high risk beds in Neonatal Intensive Care Units; Making use of some form of oxygen therapy; Since most of these patients have respiratory disorders and require oxygen to improve the clinical picture. All the newborns submitted to the procedure of collection of arterial blood gases by clinical indication and medical prescription were also included in the study.	Newborns less than 12 hours old were excluded; Due to hemodynamic and respiratory instability. As a consequence, neonates with clinical instability were also excluded; The malformed ones; Children of chemical dependents; Women seropositive for the Human Immunodeficiency Virus (HIV); Neonates who have undergone recent surgical procedures; Those who have been using sedation or analgesia (fentanyl or dormonid); Those with neurological manifestations; Such as convulsions and the children of mothers with psychiatric problems; Due to the use of some medications contraindicated for breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-2h4mpn	Effect of the Intervention applied to the Exam of Cervical Cancer Prevention and the evaluation of the adequacy of the sampling of the cells collected	Recruiting	Intervention	2019-01-16	<NULL>	<NULL>	2444	Effect of the intervention applied to the Papanicolaou Test and the Adequability of the cytopathological sample	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-07	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2h4mpn	<NULL>	Women who have already started sex life; women to undergo cervical cancer screening at the time of data collection.	Patients younger than 18 years; pregnant women; women who are in the menstrual period or have undergone total hysterectomy; collection slides that have been exposed to conditions of poor storage, transportation and other logistic factors unrelated to the preparation with the uterine cervix material; unavailability of the cytopathological report at the research place.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-2nskvs	Heart Rate Variability in children with Normal and Excess Weight	Recruiting	Observational	2019-01-16	<NULL>	<NULL>	2445	Characterization of Variability of Cardiac Frequency in Eutrophic children and with Excess Weight	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-19	Universidade de São Paulo (USP)	Escola de Artes,Ciências e Humanidades da Universidade de São Paulo (EACH-USP)	https://ensaiosclinicos.gov.br/rg/RBR-2nskvs	<NULL>	Children from 6 to 10 years; term of free and informed consent and endorsement by the child; registered in municipal schools in the city of Presidente Prudente / SP.	Children with diagnosed neurological and metabolic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-89z57d	Effect of Reiki on people&apos;s well-being and feelings	Not yet recruiting	Intervention	2019-01-16	<NULL>	<NULL>	2446	Reiki&apos;s interference in subjective well-being and positive and negative feelings	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89z57d	<NULL>	To be a server of the Federal University of Sergipe; to have never experienced therapy before; to be 18 years or older; to read and write; to commit voluntarily to four sessions of Reiki and; to respond to the instruments of collection of data	As exclusion criteria, physical and intellectual inability to respond to the questionnaires that were applied and to be on vacation or on leave in the institution was considered as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-8brxg7	Pre-exercise blood flow restriction to minimize damage in the thigh muscles	Recruiting	Intervention	2019-01-17	<NULL>	<NULL>	2447	"Ischemic preconditioning to attenuate the magnitude of eccentric exercise-induced
muscle damage in lower limb: a randomized,
double-blind, placebo-controlled clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-20	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8brxg7	<NULL>	Be a healthy male, aged 18-35 years and classified as irregularly active or active in the International Physical Activity Questionaire (IPAQ); Not being involved in strength training programs for lower limbs; not with a body mass index (BMI) of less than 18.5 kg / m-2 and greater than 30 kg / m-2; not be smokers or who use vasoactive medications and nutritional supplements regularly. Do not report musculoskeletal injury to lower limbs within 3 months prior to testing; not having uncontrolled diabetes mellitus or blood pressure; have no inflammatory rheumatologic condition or severe cardiovascular and / or pulmonary disease that prevents them from performing the evaluation and the proposed exercise; not having psychiatric disease and malignant tumors; not have presented Zika or Chikungunya in the last year.	Missing some day of collection; at any time and for any reason expressing an intention to leave the study; present a health problem that prevents them from continuing to participate in the research; use of medications, electrotherapeutic equipment or other therapeutic resources to improve pain and performance during the collection period; practicing unusual or strenuous physical activities during the days of collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-3pz4dh	Effects of a home exercise program of strength and cardiopulmonary resistivity in patients with Chronic Renal Disease	Not yet recruiting	Intervention	2019-01-18	<NULL>	<NULL>	2448	Effects of a household program of exercises in patients with Chronic Renal Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3pz4dh	<NULL>	"Diagnosis of kidney disease for more than 6 months.
Patients undergoing hemodialysis at the HCPA Nephrology Service for at least 3
months.
Age equal or superior to 18 years.
Physical conditions to perform exercises and the tests proposed in this study.
CKD stability for at least 30 days, defined by the absence of
hospitalization and / or modification of the usual therapeutic regimen."	"Presence of acute myocardial infarction in the last 3 months.
Presence of pacemakers and defibrillators making it impossible to perform the
Bioimpedance.
Active inflammatory or infectious process, evidenced by leukogram outside the
limits of normality.
Decompensated coronary artery disease.
Peripheral arterial disease.
Implantable kidney transplant candidate with live or predicted donor
transplant in the next 3 months.
Cognitive, auditory and visual changes that limit the understanding of
evaluations and interventions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-9xdn2y	Influence of the nervous system on heart rate and functional capacity after supervised physical training in patients with high blood pressure: a pilot study	Data analysis completed	Intervention	2019-01-18	<NULL>	<NULL>	2449	Autonomic heart rate modulation and functional capacity in hypertensive patients before and after supervised non-exhaustive aerobic physical training: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Fundo de Apoio ao Ensino, à Pesquisa e à Extensão – FAEPEX, Universidade Estadual de Campinas – Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-9xdn2y	<NULL>	Participants who met the following inclusion criteria were considered eligible for inclusion in the study: hypertensive patients classified in stages 1, 2 and 3 (Stage 1: SBP between 140-159 mmHg and / or DBP between 90-99 mmHg; Stage 2: PAS between 160-179 mmHg and / or PAD between 100-109 mmHg and Stage 3: SBP ? 180mmHg and / or PAD ? 110 mmHg) according to the VI Brazilian Guidelines for SAH; patients rated with very weak and reasonable physical fitness according to American Heart Association criteria, which uses the maximum oxygen consumption (ml / kg / min) for classification.	Participants who presented one of the following conditions were: non-verbal communication; Grade III obesity, ie, Body Mass Index (BMI)&gt; 40kg / m2; patients with a history of coronary disease classified as moderate to high risk (classes C and D) for physical training according to the American Heart Association criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-9q7gg4	Influence of protein and creatine supplementation on the ability to perform daily living activities, quality of life and muscle structure after stroke	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2450	Influence of Protein and Creatine supplementation on functional capacity, quality of life and muscle function after Stroke	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Medicina da Unesp de Botucatu	Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9q7gg4	<NULL>	Men older than 60 years; diagnosed with ischemic stroke; with up to 24 hours of stroke; without previous disability (Modified Rankin Scale less than 1) and who agree to participate of the study.	Patients with hemodynamic instability; in mechanical ventilation / ICU; use of pacemaker and metal prostheses; with previous renal disease; with creatinine clearance less than 30ml / min / 1.73m²; using alternative route for feeding (nasoenteral tube / gastrostomy / parenteral nutrition); patients with allergy or intolerance to any component of the study products and those who do not agree to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-7kppn2	The effect of movement velocity on the performance of leg press exercise in the musculature of elderly women with knee arthrosis	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2451	Acute effect of moviment velocity on kinetic and kinematic behavior and muscle activation in women elderly with knee osteoarthritis during leg press exercise	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	https://ensaiosclinicos.gov.br/rg/RBR-7kppn2	<NULL>	"Age over 65 years;
diagnosis of osteoarthritis of the knee using the criteria for osteoarthritis of the knee of the American College of Rheumatology (ACR, 1986) or to have grade II or III knee osteoarthritis of the Kelgren and Lawrence (KL) scale;
walking independently, without support device;
being for at least six months without practicing resisted physical exercise;
and do not present as follows:
any congenital, traumatic, infectious or deformity abnormality following injury to the knee joint that may have contributed to the development of secondary OA;
inflammatory arthritis (e.g., Rheumatoid Arthritis);
grade IV knee osteoarthritis on the KL scale;
knee flexion deformity greater than 15 degrees;
inability to walk or walk with the aid of devices;
neurological problems;
neuromuscular disease or injury;
surgery on the knee (s) in the last year;
corticosteroid injection in the last three months;
uncontrolled hypertension (&gt; 150/90 mmHg);
myocardial infarction in the last six months;
unstable cardiovascular disease;
conditions that may be exacerbated by the protocol (e.g., unstable angina);
fractures within the six-month period; present painful changes in the hips and / or ankles and / or pain in the lower back; or severe comorbidity that limits participation in the study.
Clinical guidelines established by the ACR include having knee pain on most days of the month and at least 3 of the following 6 criteria: age 50 and older, joint stiffness lasting 30 minutes, crepitation, bone sensitivity, bone augmentation, and heat palpable."	"Not participating in one of the sessions;
Any limitation that impedes the continuity of the participant in the study;
Participants with BMI&gt; 30 kg / m2 (minimize artifact at EMG)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-2p8rrh	Evaluation of the effects of microphysiotherapy in women with fibromyalgia.	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2452	Evaluation of the effects of microphysiotherapy on quality of life, heart rate variability, biochemical markers and pain in individuals with fibromyalgia.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2p8rrh	<NULL>	"Inclusion criteria will be considered: women living in the
Florianópolis and in the cities of Capão Bonito-SP, São Paulo-SP, Pinhão-PR
and Guarapuava-PR aged 18 to 80 years, with the clinical diagnosis of FM.
In addition, after the inclusion will have to have the signature of the Term of Consent
Free and Informed (ICLE)."	"The exclusion criteria adopted will be: patients with
immunodepressive agents; oncological; infectious diseases; cardiovascular, renal,
hepatic, gastrointestinal or psychiatric disorders, use of anti-inflammatory drugs
or drugs that affect the inflammatory process (before and after a week of
collection of blood), pregnant or lactating, degenerative changes in the spine,
herniated discs with motor deficit, post-surgical spine or rheumatic diseases,
will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-8rkwnw	Effects of Arginine Supplementation associated with an Exercise Training Program in Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2019-01-22	<NULL>	<NULL>	2453	Effects of Arginine Supplementation associated with Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8rkwnw	<NULL>	Patients with moderate to very severe chronic obstructive pulmonary disease; with age equal to or greater than 40 years; of both sexes.	Current smoking; presence of associated diseases that make it impossible to carry out any of the study evaluations or limit the progression of training such as osteoarthritis, severe cardiovascular and neurological conditions and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4q38c8	Subtenon Block with Ropivacaine and Bupivacaine in Cataract surgery	Data analysis completed	Intervention	2019-01-23	<NULL>	<NULL>	2454	Ropivacaine versus Racemic Bupivacaine in Episcleral Block for Phacoemulsification Facectomies: double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Hospital Alberto Rassi - HGG	Fundação Banco de Olhos de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4q38c8	<NULL>	Volunteers aged between 18 and 75 years; physical status I or II according to ASA (American Society of Anesthesiologists) criteria; both sexes; candidates for phacoemulsification facectomy surgery and intraocular lens implantation with episcleral block	Volunteers with known allergy to local anesthetic; glaucoma patients; abnormal eye movement; chronic cough; anticoagulant therapy; orbital abnormalities; inability to understand study information; block failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-22zvxw	Bone metastases treatment by image-guided freezing in patients with endocrine tumors	Not yet recruiting	Intervention	2018-07-03	<NULL>	<NULL>	2455	Cone-beam computed tomography guided percutaneous cryoablation approach of bone metastases of endocrine tumors	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Instituto de Radiologia do Hospital das Clínicas / Faculdade de Medicina da Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo - ICESP	https://ensaiosclinicos.gov.br/rg/RBR-22zvxw	<NULL>	patients with bone metastases diagnosis evidenced by imaging exams (CT, MRI and/or PET-CT) and secondary to: papillary, folicular or medullary thyroid cancer; adrenal carcinoma; neuroendocrine carcinomas; metastatic bone lesions associated with: pain; risk of fracture; risk of spinal cord compression; hypercalcemia; age over or equal 18 years old; performance status (ECOG) of 0, 1, 2 or 3; life expectation over one month; patients must present pain symptoms from bone metastases and / or localized in a region of imminent risk of instability / fracture that may progress to neurological complication (for example, vertebral metastases) or functional impairment (for example, acetabular metastases); all patients must present diagnosis confirmation from metastases biopsy; the same treated patients can be treated again if they present new lesions during the study; all patients must be evaluated for treatment indication by a multidisciplinary team; the metastatic lesions may be located at the axial skeleton, costal arches, shoulder or pelvic girdle; each bone metastases assigned for treatment must be biopsy-proven and / or presenting elevation of thyroglobulin or calcitonin levels in the needle wash, if thyroid carcinoma is present; all patients must present five symptomatic bone metastases maximum; all selected metastases must have 7.0 cm diameter maximum;	"age bellow 18 years-old; active anticoagulant treatment
non-conclusive or benign cytologic specimens
pregnancy or breast-feeding undifferentiated thyroid neoplasia (anaplastic)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-8n5n3v	Clinical Evaluation of Composite Resin Restoration After Removal of Caries Lesions Using Laser	Recruitment completed	Intervention	2019-01-23	<NULL>	<NULL>	2456	Longitudinal Clinical Evaluation of resin composite restoration after Selective Caries Removal using an Er:Yag Laser	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n5n3v	<NULL>	Inclusion criteria were: four active dentin caries lesions; permanent molars with pulp vitality; permanent molars with absence of sealants; absence of amalgam restorations; absence of glass ionomer cement; absence of composite resin restorations.	First molars without pulp vitality; presence of sealants; presence of amalgam restorations; presence of glass ionomer cement; presence of composite resin restorations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4mhs32	The role of Vitamin D on metabolic and immunology profile of postmenopausal women	Data analysis completed	Intervention	2017-06-05	<NULL>	<NULL>	2457	The role of Vitamin D on cardiometabolic and immuno-inflammatory profile of postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-05	Faculdade de Medicina de Botucatu - UNESP	Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-4mhs32	<NULL>	Last menstrual period for at least 12 months, age greater than or equal to 45 years old who accept participate and vitamin D deficiency	DAC manifest presence of current or past; Cerebrovascular arterial disease; aneurysmal disease; peripheral arterial disease; chronic kidney disease; insulin dependent diabetes; liver disease; autoimmune diseases; alcoholic or drogaditas; use of pharmacological doses of VD	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-67vp85	Efficacy of medicinal plant Aloysia for anxiety symptoms	Data analysis completed	Intervention	2019-01-24	<NULL>	<NULL>	2458	Efficacy of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in anxiety symptoms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-67vp85	<NULL>	Age between 18 and 60 years; HAM-A score of at least 18 points; No history of allergy to A. polystachya or its components or to plants from Verbenaceae family; No use of psychotropic drugs; Not in psychiatric treatment; Not have used psychotropic medicines within 2 weeks; Not be smoker; Not be heavy drinker.	Patient&apos;s request; Allergy or adverse reaction attributable to the plant; Any alcohol use within 1 week or during study; Any psychotropic drug use within 1 week or during study; Any psychiatric treatment within 1 week or during study; Smoking within 1 week or during study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-5dy35n	Evaluation of polysomnography data in the treatment of sleep respiratory disorders with intraoral language stabilization device: randomized clinical trial	Data analysis completed	Intervention	2019-01-24	<NULL>	<NULL>	2459	Evaluation of polysomnographic parameters in the treatment of sleep-disordered breathing with tongue stabilizer: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-03	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dy35n	<NULL>	patients with a polysomnographic diagnosis of mild or moderate OSAS; and who did not adapt or had no access to CPAP treatment	patients on drug treatments that may modify muscle tone; alcohol users in their daily routin;, involved in any other type of treatment for OSA; or patients who were pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-6y6thg	Influence of the use of Braces in Muscular Activation in healthy individuals or with bone and muscle complaints	Recruiting	Intervention	2019-02-01	<NULL>	<NULL>	2460	Influence of the use of Orthoses in the Muscular Activation in healthy individuals and with musculoskeletal complaints	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6y6thg	<NULL>	Individuals without complaints; with musculoskeletal complaints; male and female; out of menstrual period; over 18 years of age	Any type of injury that compromises the integrity of the musculature; Fractures in consolidation; Cognitive alterations; Visual changes that make it impossible to perform the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-6wrv5y	Effectiveness of the addition of pectoral stretching in patients with subacromial impingement syndrome: a clinical trial.	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	2461	Effectiveness of adding pectoralis minor stretches to an exercise program in patients with subacromial impingement syndrome: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-6wrv5y	<NULL>	Included:Patients over 18 years of age referred from the Adult Orthopedist Department with a clinical and imaging diagnosis of SIS type II; Who accepted and signed the informed consent.	Excluded;Patients who presented pathologies of cervical origin cervical such as radiculopathy; or other pathologies of the shoulder joint complex such as osteoarthritis in the acromioclavicular or glenohumeral joints, calcific tendinitis, adhesive capsulitis, glenohumeral instability; partial or full-thickness tear rotator cuff; etc;patients who have had history of acute trauma;previous surgery or previous fracture in the affected shoulder, patients who have had corticoid infiltration in the affected shoulder in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-3ktg93	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in breast Cancer survivors	Recruitment completed	Intervention	2019-02-01	<NULL>	<NULL>	2462	Effects of Resistance Training on quality of life, mood disorders, spinal curvature, fatigue indicators and muscle performance in breast Cancer survivors	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3ktg93	<NULL>	To be between the ages of 40 and 70; to be in the menopause; to have completed all the therapies related to the treatment of the cancer, including, surgery, radiotherapy and chemotherapy; to be at least six months after treatment; to have medical release for physical exercise; and to be performing the treatment of hormonal therapy (Tamoxifeno® or Anastrazol).	To present a diagnosis of lymphedema; uncontrolled arterial hypertension, uncontrolled cardiovascular diseases, uncontrolled neurological diseases and / or orthopedic limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-7sx8j3	The effect of visceral manipulation in patients with chronic non-specific low back pain assessed during the anterior trunk flexion movement	Data analysis completed	Intervention	2017-10-30	<NULL>	<NULL>	2463	The effect of 6-weeks Osteopathic Visceral Manipulation on the flexion-relaxation phenomenon in patients with nonspecific chronic low back pain: a protocol of randomized placebo-controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-20	Associação Educacional Nover de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7sx8j3	<NULL>	Age 18 to 65 years; nonspecific low back pain for at least 3 months; pain intensity of at least 2 points as measured with 0 - to 10 - point Pain Numerical Rating Scale; functional constipation according criterias to Rome III.	"Patients with any contraindication to osteopathic visceral manipulation or that submitted to treatment at least 6 months ago. previous spine surgery within the preceding 6 months;  serious spinal pathology (e.g., metastasis, spinal fracture, inflammatory, and infective diseases, caudal equine syndrome, canal stenosis);
Serious cardiovascular or metabolic diseases; pregnancy; red flags signals; nor currently in an acute inflammatory phase of known gastrointestinal or urinary diseases (such as cholecysticis, renal calculi, peritonitis, appendicitis)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-2dy25r	Effects of prolonged knee use on fear of individuals with anterior knee pain	Recruitment completed	Intervention	2018-08-01	<NULL>	<NULL>	2464	Effects of the prolonged use of a knee brace on the kinesiophobia of individuals with patellofemoral pain: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-2dy25r	<NULL>	Anterior knee pain when performing at least two of the following activities: sitting for prolonged time, squatting, kneeling, running, climbing and descending stairs, jumping and landing; insidious onset symptoms lasting at least 4 months; the worst pain level in the previous month corresponding to at least 3 centimeters in the Visual Analogue Pain Scale (VAS); scores lower than 83 in the Knee Pain Scale (AKPS).	Individuals with a sign or symptoms of any other knee dysfunction; recent history of surgery in any lower limb joint; history of patellar subluxation, clinical evidence of meniscal injury or ligament instability; symptomatic osteoarthritis in any lower limb joint; patellar tendon pathology; referred pain coming from the lumbar spine, hips, ankle or feet; presence of neurological disease; presence of inflammatory process or symptoms of overload; prior physiotherapy treatment for PFP.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-76tbqs	Effects of a natural compound on the musculature and strength of individuals who exercised and received bodybuilding training	Recruitment completed	Intervention	2018-01-31	<NULL>	<NULL>	2465	Effects of urinary acid on muscle mass and strength in physically active individuals undergoing resistance training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-30	Faculdade de Nutrição	Faculdade de Educação Física e Dança	https://ensaiosclinicos.gov.br/rg/RBR-76tbqs	<NULL>	adult men, healthy, physically active (who performed some physical exercise, minimum duration of 150 minutes per week for at least six months, being optional strength training), age between 18 and 35 years, BMI&gt; 18.5 and &lt;29 kg / m², with availability to train three times a week in the Faculty of Physical Education of the Federal University of Goiás (FEFD / UFG), in the evening period, average protein intake of 1.6 g / kg without supplementation and that they agreed to suspend their physical activities during the study period.	"individuals who reported using supplements
(including vitamins), were smokers, had heart disease, liver disease, leukopenia, thrombocytopenia, pancreatitis, gallstones, kidney disease, diabetes, pneumonia, sepsis or infection and dysphagia for capsules."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8f8vfj	The effect of the psychological treatment in Cognitive-Behavioral Therapy for the Treatment of Posttraumatic Stress Disorder	Recruiting	Intervention	2019-02-05	<NULL>	<NULL>	2466	Efficacy of Cognitive-Behavioral Therapy for the Treatment of Posttraumatic Stress Disorder	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8f8vfj	<NULL>	Over 18 years old; diagnosis of Posttraumatic Stress Disorder.	Risk of suicide; pregnancy; borderline and antisocial personality disorders; psychosis; psychoactive substance abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-89kchg	Benefits of traditional, functional and calisthenic training in physical fitness, cardiovascular health and quality of life of the elderly	Data analysis completed	Intervention	2019-02-05	<NULL>	<NULL>	2467	Influence of Traditional, Functional and Calisthenic Training on Physical Fitness, Cardiovascular Health and Quality of Life in Older Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-29	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89kchg	<NULL>	Be physically independent; Be 60 years of age or older; Do not present medical history of heart disease, musculoskeletal disorders, diabetes, uncontrolled hypertension or any other dysfunction that restricts the practice of high intensity physical exercises; Do not use hormone therapy medications, lipid-lowering agents, hypoglycemic agents and anti-inflammatories	Regular participation in systematic exercise programs in the three months prior to the present study; Presence of uncontrolled cardiovascular and musculoskeletal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-2b9zd2	The effect of Relaxation Intervention, Mental Imaging and Spirituality (RIME) in patients with chronic kidney disease on hemodialysis: a randomized controlled trial	Recruitment completed	Intervention	2019-02-05	<NULL>	<NULL>	2468	The method of Intervention RIME in patients with chronic kidney disease on hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2b9zd2	<NULL>	Men and women aged 18-59 years;Have a medical diagnosis of Chronic Renal Disease;Being on hemodialysis for at least six months;Being from any religion or even being atheist.	Present some kind of cognitive alteration, such as dementia or cognitive deficits;Have a diagnosis of Chronic Renal Disease but are not undergoing hemodialysis;Present previous reports or experiences of psychotic pictures, or other mental illnesses;Do not accept RIME intervention as an adjunct to your conventional treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-9hspyy	Fluoride present in toothpaste as an indicator of its availability in saliva	Data analysis completed	Intervention	2019-02-06	<NULL>	<NULL>	2469	Chemically soluble fluoride found in toothpaste as a predictor of fluoride bioavailability in saliva	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-9hspyy	<NULL>	"Good general and oral health;
Salivary flow unstimulated within normalities."	"Participants using orthodontic appliances;
Participants who use medications that affect the salivary flow."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8r23ds	Effect of applying therapy with light emitting diodes on healthy men	Recruitment completed	Intervention	2019-02-06	<NULL>	<NULL>	2470	Acute effect of phototherapy by means of light emitting diodes (LEDs) on cardiovascular coupling after constant loading exercise in patients with type 2 diabetes mellitus	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8r23ds	<NULL>	Healthy men; aged 20-35 years	Cardiovascular and respiratory disorders; occurrence of a cutaneous lesion or local infection in the forearm area; history of skeletal muscle injury in the previous six months; and chronic joint disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-23b3nc	Project Migraine, Brain Stimulation and Full Attention	Recruiting	Intervention	2019-02-06	<NULL>	<NULL>	2471	Migraine Project, Neurostimulation and Mindfulness	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-23b3nc	<NULL>	"Patients of both sexes, aged 18-65 years, who have been diagnosed clinically as having chronic migraine, according to the third edition of the Classification of the International Headache Society (ICHD-3) will be selected.
Only patients who will be able to continue treatment in the twelve sessions during the four consecutive weeks pre-programmed will be accepted, although up to three alternating or two justified faults are tolerated, and these should be reset on the following business day, in order to minimize the dropouts and promote adherence to treatment. Flexible hours will be offered to receive the therapy, as well as direct contact, through telephone contact with the participants, confirming the evaluation dates and reinforcing adherence to the treatment."	Exclusion criteria include the presence of headache attributed to some other neurological pathology or associated neuropsychiatry, the use of drugs modulating central nervous system (CNS) activity, presence of metallic implants located in the head, and patients with pacemakers cardiac.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-4fbdz5	Factors associated with damage accrual in lupus patients from Rio de Janeiro, Cales project analyses	Recruitment completed	Observational	2019-02-08	<NULL>	<NULL>	2472	Cales project Association between systemic lupus erythematosus and cervix cancer	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-07-20	Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas	Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-4fbdz5	<NULL>	Systemic lupus erythematosus patients evaluated previously ten years ago and followed at the Hospital Universitário Pedro Ernesto.	Infection with HIV or HCV or HBV; or refusal to participate by the patient.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-5fhmpq	Clinical evaluation of a dental adhesive containing zinc and copper nanoparticles in composite resin restorations in dental lesions near the gingiva	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2473	Clinical Evaluation of an Universal Adhesive System containing Zinc and Copper Nanoparticles on Composite Restorations in Non-Carious Cervical Lesions: a Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5fhmpq	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-9phj2q	Effect of physical exercise on motor parameters and blood markers in post-stroke patients	Recruitment completed	Intervention	2019-02-11	<NULL>	<NULL>	2474	Effect of physical exercise on clinical-functional outcomes, modulation of epigenetic markers and levels of brain-derived neutrotrophic factor (BDNF) in peripheral blood in post-stroke patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-9phj2q	<NULL>	Inclusion criteria adopted will be stroke for at least 6 months; be over 59 years old and have the ability to walk without using a bracing.	Individuals will be excluded if they use drugs containing HDAC inhibitors; such as Valproic Acid; other associated neurological diseases; orthopedic and / or musculoskeletal problems affecting gait; cognitive impairment identified by the Mini Mental State Examination (MMSE); disability the risk of deep venous thrombosis; have sensory deficits in the hemiparetic limb; cardiac pacemaker patients; pregnant women and individuals with metal plaques and cancer in the region of the fibula head (site that will be stimulated by FES).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-3pq5th	Use of phone calls in the prevention of diabetic foot	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2475	Evaluation of the use of telephone intervention in the prevention of diabetic foot	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3pq5th	<NULL>	Those who are 18 or older will be included in the study; patients diagnosed with Diabetes mellitus for at least 2 years with or without arterial hypertension; have a fixed telephone line or personal cellular telephone.	And exclusion criteria will be: to have the diabetic foot and some cognitive deficit that makes it impossible to respond directly to the instruments of collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8hnvm7	Comparison of Phototherapy versus Therapeutic Ultrasound in the Treatment of Shoulder Injury	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2476	Comparison of the red and infrared LEDs in relation to therapeutic Ultrasound treatment on chronic Tendinopathy of shoulder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-8hnvm7	<NULL>	Medical diagnosis characterized as chronic tendinitis of the shoulder, sign the document informed consent, age between 45 and 70 years, and not using anti-inflammatory or analgesic medication at the time of the study	No chronic tendinitis of the shoulder, age out of the studied range, using anti-inflammatory or analgesic drugs, presenting other pathologies associated with tendinitis, presenting neoplasm, patients with photo sensibility, treated with other methods recently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-6c7tns	Effects of active exercises on fibromyalgia	Data analysis completed	Intervention	2019-02-12	<NULL>	<NULL>	2477	Effects of a postural orientation program in patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6c7tns	<NULL>	"Women aged 30-55 years; fulfillment of the
American College of Rheumatology 1990 or 2010 criteria for diagnosis of FM [3]; residence in the metropolitan area of Recife, PE; stable psychological, physical, and drug therapy in the preceding month."	Patients attending physiotherapy sessions, using gait assistance devices, suffering from associated autoimmune rheumatic diseases, or presenting uncontrolled comorbidities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-4q83kx	Evaluation of sleep, quality of life and ability to perform exercise before and after the use of an apparatus to treat sleep disorders in adults with non-fibrocystic bronchiectasis and obstructive sleep apnea	Not yet recruiting	Intervention	2019-02-12	<NULL>	<NULL>	2478	Evaluation of sleep quality, quality of life and functional capacity pre and post-PAP and its repercussions in adults with non-cystic fibrosis bronchiectasis and obstructive sleep apnea - a three months follow-up study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Centro Universitário Augusto da Motta	Centro Universitário Augusto da Motta	https://ensaiosclinicos.gov.br/rg/RBR-4q83kx	<NULL>	Patients with clinical diagnosis of BNF (after confirmation by HRCT and sweat test) of both genders; between 18 and 90 years old; after agreeing to participate in the study; signing the ICF; with no cognitive deficit that would interfere in the comprehension to answer the questionnaires; clinical stability at least 1 month; long-term bronchodilator use; presence of OSA confirmed by PSG.	Patients with bronchiectasis due to CF (chloride level in sweat&gt; 60 mmol / L); smoking history; presence of other pulmonary diseases (eg COPD and asthma) and / or other comorbidities that could influence the diagnosis and/or prognosis in the outcome of the disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-9pbvnm	Evaluation of the efficacy of a low cost Model for superficial vein access using ultrasound	Data analysis completed	Intervention	2019-02-12	<NULL>	<NULL>	2479	Evaluation of the efficacy of a Non-Human Experimental Model  for  superficial venous Puncture guided by ultrasound	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Faculdade de medicina do ABC	Faculdade de medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-9pbvnm	<NULL>	Nurses of the clinical body of the teaching hospital Padre Anchieta. Patients hospitalized at the Padre Anchieta Teaching Hospital; with medical indication of peripheral venous access; over 18 years old; with superficial vein in the upper limbs; with gauge greater than 0.35 cm and up to 1.5 cm deep; signature of the free and informed consent form.	Failure to accept and sign the informed consent form; Under 18; Greater than 90 years; There is no superficial vein in the upper limbs, with a caliber greater than 0.35 cm and up to 1.5 cm deep (distance between the anterior wall of the vein and the skin).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-6vzh6p	Study of the efficacy of Light Stimuli in critically ill patients	Recruiting	Intervention	2019-02-14	<NULL>	<NULL>	2480	Feasibility study of Photodynamic Therapy in patients in the critical area	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-6vzh6p	<NULL>	Both genders; under intensive care	oral cavity sanitized on the day of collection; length of stay longer than 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-5csqm4	Fish oil in adolescents for Acne treatment	Recruiting	Intervention	2019-02-15	<NULL>	<NULL>	2481	Effects of supplementation of the dry extract of Camellia sinensis and Fish oil on the nutritional, biochemical-inflammatory and metabolic profile of adolescents with different degrees of acne vulgaris	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5csqm4	<NULL>	Patients with uncontrolled steatorrhea and vomiting will not be included in the study. In addition to those who are taking anti-inflammatory drugs (non-steroids - ANES and corticosteroids), antibiotics or those with serious diseases, kidney, liver, etc.	Patients who discontinue supplements for 7 consecutive days and who fail to follow any guidelines given for the study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-565p4b	Effect of perioperative venous lidocaine on postoperative ileus time and hospital discharge after bariatric surgery by Laparoscopic	Recruitment completed	Intervention	2019-02-15	<NULL>	<NULL>	2482	Evaluation of the effect of perioperative venous Lidocaine on the return time of intestinal function and the length of hospital stay after Laparoscopic Gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal de São Paulo	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-565p4b	<NULL>	age above 18 years; obesity grade 2 or 3; under 65 years	BMI below 35; BMI above 50; children under 18; age over 65 years; allergic to lidocaine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-3253dz	Effect of Pilates Method on muscle strength, activities of daily living, amount of fat, and quality of Life in women undergoing treatment for Breast Cancer	Recruiting	Intervention	2019-02-15	<NULL>	<NULL>	2483	Effect of Pilates Method on Biomechanical, Functional, Body Composition and Quality of Life in women undergoing treatment for Breast Cancer: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3253dz	<NULL>	To be part in this study participants have to be forty years or older, have breast cancer stage one to three certified by the physician and recorded in the medical promptuary; undergoing hormonetherapy, to have an authorization to practice Mat Pilates and the tests; live in the city of Presidente Prudente; not have practiced any type of systematic physical activity six month before the study, and sign the consent form	Participants will be excluded if they have three consecutive non attendance to the intervention; more than seventy five percent of absents within a month during the  intervention; physical impairments to perform the tests and the Mat Pilates intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-76dhsn	Evaluation of the heart valve (Optimum TAVI-Labcor)	Recruiting	Intervention	2019-02-19	<NULL>	<NULL>	2484	Clinical evaluation of the Aortic Valve Optimum TAVI-Labcor	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-11	Labcor Laboratórios Ltda	Labcor Laboratórios Ltda	https://ensaiosclinicos.gov.br/rg/RBR-76dhsn	<NULL>	Individual with aortic stenosis presenting the following echocardiographic criteria: Mean gradient greater than 40 mmHg or jet velocity greater than 4.0 m / s or aortic valve area less than 0.8 cm2 (or indexed aortic valve area less than 0.5 cm2 / m2); Symptomatic symptom due to valvular stenosis, demonstrated in NYHA II Functional Classification; STS greater than 8; Male or female; From any demographic area; Age 70 years; Coexisting predictive conditions of 50% probability of death within 30 days after surgery or &quot;irreversible serious condition&quot; evaluated by at least 2 investigators; The participant who presents risk of death or irreversible morbidity in conventional valve replacement surgery and probability of success exceeding 50% in transcatheter surgery should be evaluated for the medical or anatomical factors that led to this conclusion; The participant or legal representative must be informed about the nature of the study, he / she must agree to participate and sign the consent form; The participant must be willing to participate in this Protocol of Clinical Investigation, as well as, to allow post-implant follow-up.	"Participants unable to comply with the Clinical Investigation Protocol; Evidence of acute myocardial infarction, 1 month before surgery (defined as myocardial infarction
with Q wave, or without Q wave with elevation greater than or equal to twice the dosage of creatine kinase in the presence of elevation of CK-MB and / or elevation of troponin level - WHO definition; Congenital unicuspid or bicuspid aortic valve, or not calcified; Mixed aortic valve disease - stenosis and aortic regurgitation, with predominant aortic regurgitation greater than 3+; Any cardiac invasive therapeutic procedure performed within 30 days prior to the procedure or 6 months if the procedure performed was coronary stent implantation with drug elution; Previous existence of cardiac valvular prosthesis in any position, prosthetic ring, severe calcification of the mitral annulus, or severe mitral regurgitation greater than 3+; Blood dyscrasia, defined as leukopenia - WBC less than 3000 mm3, acute anemia Hb less than 9 mg%, thrombocytopenia - platelet count less than 50,000 cells / mm³, history of hemorrhagic diathesis or coagulopathy; Untreated coronary disease, requiring revascularization; Hemodynamic instability, requiring inotropic therapy or mechanical devices for hemodynamic support; Need for emergency surgery for any reason; Hypertrophic cardiomyopathy with or without obstruction; Severe ventricular dysfunction with left ventricular ejection fraction &lt;20%; Echocardiographic evidence of intracardiac mass, thrombus or vegetation; Active peptic ulcer, or upper gastrointestinal bleeding within 3 months before
Procedure; Known hypersensitivity or contraindication to aspirin, heparin, ticlopidine, or clopidogrel, or contrast sensitivity, which may not be adequately pre-medicated; Native aortic annulus size less than 21 mm or greater than 23 mm, determined by the surgeon using CT and or echocardiogram; Stroke or recent transient ischemic attack past 6 months; Renal insufficiency - creatinine greater than 3.0 mg / dL and end-stage renal disease requiring chronic dialysis; Life expectancy less than 12 months due to non-cardiac comorbidities; Significant disease of the abdominal or thoracic aorta, including aneurysm - defined as maximal luminal diameter 5 cm, severe tortuosity, atheroma in the aortic arch - especially if greater than 5 mm, protruding or ulcerated, narrowing of the abdominal aorta - especially if there is calcification and irregular surface , or severe &quot;unfolding&quot; and tortuosity of the thoracic aorta; Features of the iliofemoral vessel that prevents the safe placement of the catheter, such as severe calcification, severe tortuosity or vessel diameter less than 7 mm to 22F; Currently participating in the clinical investigation of another medical device; Active bacterial endocarditis or other active infections; Native aortic valve leaflet, near the coronary ostia, extensively calcified."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-62wvhp	A randomized clinical study using Mta for Endodontic Treatment as a material in milk teeth	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2485	Randomized clinical assay of use the Mta in Pulpar Therapy of deciduous teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Angelus Industria de Produtos Odontológicos S/A	CCS - COU - Programa de Pós-Graduação em Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-62wvhp	<NULL>	Healthy children;molar teeth with deep carious lesion;provoked and non-persistent pain;maximum root resorption of up to 2/3 root;restorative tooth;tooth that allows absolute isolation	Primary molars with percussion sensitivity, spontaneous and persistent pain, interradicular bone loss, internal resorption, less than 2/3 of root, edema, fistula, abscess, pulp calcifications, pathological mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7v6r3t	Effect of exercises to mobility in the orofacial musculature in volunteers with temporomandibular dysfunction: brain function	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2486	Effect of isotonic exercises in the orofacial musculature in volunteers with temporomandibular dysfunction: neurophysiological	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7v6r3t	<NULL>	Age between 18 and 60 years old; temporomandibular disorder muscular diagnostic reach by research diagnostic criteria; pain between 4 and 10 in numeric scale.	Displacement of the temporomandibular joint; arthralgia; osteoarthrosis; osteoarthritis; advanced neurological and psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4dc5yc	Comparison of High Fidelity Simulator versus Dramatization: impact on satisfaction, self-confidence and knowledge of nursing students	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2487	High Fidelity Simulator x Dramatization: impact on satisfaction, self-confidence and knowledge of Nursing students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Escola de Enfermagem de Ribeirão Preto - USP	Universidade do Oeste Paulista - UNOESTE	https://ensaiosclinicos.gov.br/rg/RBR-4dc5yc	<NULL>	"Students regularly enrolled in the 3rd and 4th year of the undergraduate nursing course.
Older than 18 years;"	Failure to comply with the study steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-92r54q	Autonomic heart modulation in children and adolescents with Cerebral Palsy during task using virtual Technology	Not yet recruiting	Intervention	2019-02-25	<NULL>	<NULL>	2488	Autonomic cardiac modulation in children and adolescents with Cerebral Palsy during Virtual Reality task and its correlations with participation and functionality	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-09	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92r54q	<NULL>	Children and adolescents of both groups should be aged from 5 to 21 years old, also they must have a clear understand of the proposed activities. Statement of informed consent will be signed by a legal guardian. All participants from the experimental group (GCP) should have diagnosis of cerebral palsy. Additionally, they should be classified at levels I, II, or III of the Manual Ability Classification System (MACS). To standardizes the sample according to ICF, participants with CP should present musculoskeletal functions in the mobility of several joints of the upper limbs with mild and moderate deficiencies (b7101.1 and b7101.2), trunk muscle tonus with mild deficiency (b7355.1) and mild or moderate upper limb tonus (b7358.1 and b7358.2). Regarding to learning, application of knowledge, accomplishment of tasks and communication all individuals will have light deficits in concentration and attention (d160.11), in performing a simple task (d2100.11) and in receiving oral messages (d310.11). These domains were chosen because they are the most important to enable the execution of the proposed task of touching the computer key at the exact moment or enabling to move towards the virtual environment.	Children that have undergone surgical procedures or has taken neurolytic block 12 months prior to the training sessions will be not included in the present research. Children with Gross Motor Function Classification System (GMFCS) level V (most severe CP) or who have severe visual or hearing impairments, or photosensitive epilepsy will be excluded. Furthermore, children with other pathologies and secondary disabilities will also be excluded, such as orthopedic deformity with indication for surgery, Epilepsy, Metal implant in the skull or use of hearing aids. ?	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-2ytjzw	The influence of pilates in the treatment of low back pain	Recruiting	Intervention	2019-02-26	<NULL>	<NULL>	2489	Influence of the pilates method in the treatment of nonspecific chronic low back pain. Randomised and controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-2ytjzw	<NULL>	Volunteers aged between 18 and 35 years; Lumbar pain of degree greater than or equal to 3 on numeric scale of pain; Pain for 12 weeks or more without this relates to any pathology or specific cause.	Volunteers who have chronic low back pain of less than grade 3 and/or related to specific diseases or causes, as well as slipped discs, history of fractures in the spine, surgery, tumors, pregnancy and signs of neurological compressions; Below the age of 18 years or greater than 35; Volunteers who are receiving medical treatment and/or physical therapy will also be excluded from the search.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-6fgg7b	Effect of Cognitive Stimulation on falls in the elderly	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	2490	Effect of Cognitive Stimulation on the prediction of Falls in physically active elderly people	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6fgg7b	<NULL>	Do not have dementia; Do not present severe visual impairment or blindness;Do not present severe hearing loss or deafness; No hemiparesis or hemiplegia due to stroke; Do not present neurodegenerative disease; such as: Parkinson&apos;s disease, Alzheimer&apos;s; Multiple Sclerosis; Amyotrophic Lateral Sclerosis; among others; To be able to wander without using an auxiliary gear; Have the proper medical control of chronic diseases and risk factors; according to medical guidance. Example; Diabetes mellitus and Systolic Arterial Hypertension controlled by drug; ccording to the prescription of a doctor;	1. miss to 25% or more of the total number of meetings held; 2. Suffering hospitalization due to serious reason or hospitalization for more than 24 hours; 3. By choice, leave the research; 4. Suffering Stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7yyznm	Evaluation of different treatments for lesions on the cervix	Recruiting	Intervention	2019-02-26	<NULL>	<NULL>	2491	"130/5000
Clinical evaluation with simplified polishing techniques in composite resin restorations in caries-free cervical lesions."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-15	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7yyznm	<NULL>	"Adults between the ages of 18 and 60;
Non-carious cervical lesions (LCNC) present in posterior teeth in at least 2 hemiarcs, (splited month study model, with the following characteristics: at least 1mm deep, lesions larger than approximately 5 mm in the occlusal-gingival sense and about 2 to 3 mm deep);
Absence of periodontal disease;
LCNC teeth should have occlusal contact with the antagonist;
have occlusal balance and absence of premature contacts."	"To have active periodontal disease;
have any degree of tooth mobility;
Have uncontrolled caries activity;
Xerostomia;
Being in orthodontic treatment;
Bearing mandibular temporal dysfunction;
History of systemic diseases with repercussions on the gingiva and periodontal tissues;
History of adverse reaction to any of the materials used in this study;
have parafuncional habit;
Use of myorelaxant apparatus;
Pregnancy or lactation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-9rf33n	Application of an Electrical Therapy Technique on different body parts for Treatment of Urinary Urgency.	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	2492	Comparison of the effects of Transcutaneous Electrostimulation of the Tibial Nerve with Parassacral in women with Urinary Urgency: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9rf33n	<NULL>	Women over the age of 18; with urinary urgency, self-reported and confirmed by a score greater than or equal to 8 in the Overactive Bladder - Validated 8 - Question Awareness Tool (OAB-V8)	To present stress urinary incontinence without symptom of urgency; being with urinary tract infection during the collection period; presenting habits of alcoholism, smoking or drug addiction; lesions and altered cutaneous sensitivity in the place where the procedure will be applied; cognitive deficit; treating (medication or physical therapy) for urinary incontinence or overactive bladder; to have any neurological disease; being in the gestational or puerperium period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7n55nz	Effect of Lasertherapy in Patients with High Blood Pressure	Not yet recruiting	Intervention	2019-02-27	<NULL>	<NULL>	2493	Effect of Irradiation with Intravascular Laser on Hemodynamic Variables of Hypertensives Patients: Study Protocol for Blinded Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	Associação Educacional Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7n55nz	<NULL>	Hypertensive individuals with ages between 30 and 80 years; with a diagnosis of systemic arterial hypertension declared by medical certificate stages I or II and evidenced in ambulatory blood pressure monitoring; with drug therapy of at least 4 weeks.	Patients with hypotension prior to the application of laser; pregnant women; with glaucoma diagnosis;  using electronic implants - such as a cardiac pacemaker; with epilepsy; seizures;  history of neoplasias; photosensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-66tppc	Comparative results of the use of corticoid and hyaluronic acid in the treatment of shoulder arthrosis.	Recruitment completed	Intervention	2019-02-28	<NULL>	<NULL>	2494	Hilano G-F 20 versus triamcinolone in the treatment of primary shoulder osteoarthrosis. Randomized controlled clinical trial.	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66tppc	<NULL>	Adult patients without distinction of age or gender; Present diagnosis of primary shoulder osteoarthrosis with radiological confirmation, Segment availability during the study period; Have had previous conservative treatment without improvement of symptoms for a minimum period of 6 months; EVA of pain&gt; or equal to 4; Have signed an informed consent form to participate in the study.	Shoulder previous surgery, Shoulder viscosupplementation, Rotator cuff arthropathy, Adhesive capsulitis, Shoulder osteoarthrosis secondary to fracture, infection, osteonecrosis, rheumatologic disease, Continuous use of corticoid, Chronic treatment with immunosuppressive or anticoagulant drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-52c4wt	Physical exercise in patients with pacemakers	Recruitment completed	Intervention	2019-02-28	<NULL>	<NULL>	2495	Effect of an exercise program on patients with artificial pacemakers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Faculdade de Medicina da Universidade Federal de Goiás	Faculdade de Medicina da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-52c4wt	<NULL>	Will be included in the study sedentary patients with artificial pacemaker for at least six months, of both sexes, without cognitive deficit, aged 18 years or more, in a follow-up regimen in the Laboratory of Electrophysiology and Pacemaker of the HC-UFG or at the Arrhythmias and Pacemaker Ambulatory of Santa Casa de Misericórdia de Goiânia.	Patients who practice regular physical activity (&gt; 150 minutes of moderate intensity physical activity per week), unstable angina, implantable cardioverter defibrillator (ICD), cardiac resynchronizer, cardiac surgery less than three months, heart failure ( NYHA class III-IV), diabetes mellitus (fasting glycemia&gt; 180 mg / dL and / or glycated hemoglobin&gt; 7.0%), chronic renal failure (glomerular filtration &lt;50 ml / min / 1.73m2), left ventricular thrombi, any clinical condition that would prevent the practice of physical activity or exercise test (ET), and the impossibility of attending the rehabilitation sector three times a week during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-3x8gp8	Learning of the Movement and health conditions of children and adolescents living in Shelter	Recruiting	Intervention	2019-02-28	<NULL>	<NULL>	2496	Anthropometric Profile and Motor Learning in children and adolescents Institutionalized in Shelter	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade do Oeste Paulista - UNOESTE	Universidade do Oeste Paulista - UNOESTE	https://ensaiosclinicos.gov.br/rg/RBR-3x8gp8	<NULL>	Individuals institutionalized and non-institutionalized in shelter; with the age group of 6 to 18 years; Signature of the Consent Term; Term of Assentiment.	Neurological, cognitive, visual, auditory deficits, will be unable to comprehend and perform tasks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-2n932c	Acute effect of Whole Body Vibration in patients with Rheumatoid Arthritis	Recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2497	Acute effect of the Whole Body Vibration in the push up modified position in physical and functional parameters in upper limbs of patients with Rheumatoid Arthritis	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação de Amparo à Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2n932c	<NULL>	Women aged 40-60 years, according to the American College of Rheumatology criteria for RA, with at least 6 months of evolution. Some degree of disease activity should be present and pharmacological treatment should be stable for at least 1 month prior to the study, including analgesics, non-steroidal anti-inflammatory drugs, glucocorticoids (must be equal to or less than 15 mg / day prednisone or equivalent). The activity of the disease will be considered with the presence of signs and symptoms that, in the judgment of the physician, would require alteration of the therapy or progression to the more aggressive treatment regimen. Patients should be able to respond to the Health Assessment Questionnaire (HAQ) and global assessment of the patient&apos;s treatment and visual analog pain scale (VAS).	Patients who have sensory disorders, active infection, alcoholism or drug abuse, are pregnant or breastfeeding, using anticoagulants or other complementary treatment, presence of any concomitant illness that will prevent them from attending the sessions, presence of any another rheumatic disease, associated or not, which could interfere with the assessment of efficacy and safety and presence of serious complications of RA or that the disease is advanced. During the study, patients will maintain prior drug therapy without adjustments. Participants will be able to use analgesic during the study period if they really feel the need. However, it will be considered as data loss or a new date will be scheduled for data collection. Intra-articular infiltrations or other procedures, such as physical therapy or corrective surgeries, will not be accepted. and will not be able to use analgesics for pain. Intra-articular infiltrations or other procedures, such as physical therapy or corrective surgeries, will not be accepted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-395ffs	Physiotherapeutic treatment in people who underwent hip replacement surgery	Recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2498	Influence of exercises proprioceptive and strengthening  on strength and activation of stabilizer muscles in individuals submitted to total hip arthroplasty: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-03	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-395ffs	<NULL>	Age between 40 and 85 years; performed ATQ due to OA; four to five weeks postoperatively; who are not enrolled or participating in another physiotherapeutic treatment program; reside in Campo Grande or region.	History of stroke; Parkinson&apos;s disease; gait disturbances of neurological origin; clinical depression or disease that compromises the level of cognition; revisions of THA, postoperative complications such as infection or dislocation; cardiopulmonary contraindications to perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-6pkvss	Study of a mobile exercise app (Sworkit Personal Trainer) on physical evaluation, blood pressure and heart rate	Recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2499	Effect of a training app (Sworkit Personal Trainer) on body composition, physical fitness and hemodynamic responses of healthy subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade Uninassau São Luís	Faculdade Uninassau São Luís	https://ensaiosclinicos.gov.br/rg/RBR-6pkvss	<NULL>	"Men and Women, over 18 years of age;
Agreement and signature of the Informed Consent;
Sedentary according to the International Physical Activity Questionnaire (IPAQ)"	- Joint or muscular diseases that could prevent them from joining the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-2zhgjw	Use of sodium nitroprusside and its effect on negative symptoms in treatment-resistant schizophrenia	Recruitment completed	Intervention	2019-03-01	<NULL>	<NULL>	2500	Use of sodium nitroprusside in repeated doses, in potentiation of typical and atypical antipsychotics, and its effect on negative symptoms in treatment-resistant schizophrenia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-05-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2zhgjw	<NULL>	Male or female gender; diagnosis of schizophrenia and antipsychotic treatment; be of legal age and be between the ages of 18 and 60; refractory population, ie patients who have used at least two typical or atypical antipsychotics, for at least 6 weeks each of the antipsychotics.	Relevant medical condition (cardiovascular diseases, neurological diseases, renal failure, liver disease, hypothyroidism, hyponatremia, hypovitaminosis B12, pregnancy, breastfeeding); history of hypersensitivity and / or allergy to sodium nitroprusside; diagnosis of substance abuse or dependence according to DSM-IV-TR criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4kkq2h	Silver Hydrofibrate versus collagenase curative in the control of venous ulcer infection: a randomized clinical trial	Not yet recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2501	Hydrofiber with silver versus colagenase in the control of surface infection and biofilms of venous ulcers: randomized clinical trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4kkq2h	<NULL>	Participants will be the adult patients who were seen at the Chronic Ulcers Clinic of the Faculty of Medicine of Botucatu during the study period, presenting an age of 18 years or older, chronic venous ulcer, open ulcer over 6 weeks, with clinical signs of infection superficial.	"Ulcers of other etiologies (peripheral arterial disease, haematological causes, neoplastic, infectious, etc);
Infected ulcers, that is, when associated with erysipelas, cellulitis or lymphangitis due to the need for systemic antibiotic therapy;
Have a history of hypersensitivity to the treatments proposed.
Have venous ulcer associated with peripheral arterial disease that will be characterized when the ankle-arm systolic index  is less than 0.8 and / or absence of distal pulses, mainly tibial.
Patients will be assessed clinically and with a script to characterize venous ulcer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-9crkxr	Barriers to perform home tasks oriented soon after stroke.	Not yet recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2502	Barriers to orientation adherence for the practice of home-based tasks in the subacute post stroke phase.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9crkxr	<NULL>	Individuals with primary stroke; individuals with subacute AVE; No cognitive problems that impair participation in the research, evaluated through the Mini Mental State Examination (MMSE), presenting scores higher than 13 for illiterates and 18 points with school instruction (BERTOLUCCI et al, 1994); Age above 18 years; Residents of the region of Florianópolis and Greater Florianópolis; Do not have other neurological deficits (eg Parkinson&apos;s disease) and / or orthopedic not related to stroke.	Presence of hearing disorders that may compromise communication with the evaluators, presenting another stroke event or other health emergency that requires hospitalization during the period of data collection; not to remain in the home environment after hospital discharge in the subacute phase after stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7fqyyd	Efficacy of virtual reality exposure therapy for the fear of flying.	Not yet recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2503	Efficacy of virtual reality exposure therapy for the fear of flying: a randomized controlled trial.	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Rio de Janeiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-7fqyyd	<NULL>	DSM criteria for specific phobia of airplanes; subclinical panic disorders; subclinical agoraphobia (provided that panic symptoms do not interfere with VR exposure); generalized anxiety disorder (GAD), since flying is the main stimulus of fear; signing a form consent.	Participants who are not literate; psychopathological disorder that require immediate treatment; suicide risk; mentally retarded; dependence of psychoactive substances; cardiovascular or respiratory disease presenting some risk; pregnant; psychotic disorder; antisocial personality disorder; schizophrenia; mania; participants in concomitant psychotherapeutic treatments; epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-489ww6	Respiratory system evaluation in treatment of acute pulmonary exacerbation in children and adolescents with Cystic Fibrosis	Recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2504	Evolution of respiratory system evaluation parameters after treatment of acute pulmonary exacerbation in children and adolescents with Cystic Fibrosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade do Estado de Santa Catarina	Centro de Ciências da Saúde e do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-489ww6	<NULL>	Children and adolescents with CF; from one month to 15 years of age; hospitalized to IVA for treatment of acute pulmonary exacerbation; oriented; collaborative, in the case of children older than five years; and without neurological deficit; without auditory deficit; without visual deficit; they may not be in invasive mechanical ventilation support.	Children / adolescents who are unable to perform or terminate spirometry;  unable to perform or terminate IOS;  unable to perform or terminate functional/exercise capacity tests; requiring surgical intervention; requiring ventilatory support.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-3q52x4	Effect of physical exercise in the context of depression and its respective factors in obese individuals	Recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2505	Effect of physical exercise in the context of depression and its respective factors in obese individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Jeronimo Costa Branco	Universidade Franciscana - UFN	https://ensaiosclinicos.gov.br/rg/RBR-3q52x4	<NULL>	The individual must be linked to one of the 14 ESF of the municipality of Santa Maria-RS; To present the Body Mass Index that classifies it as obese (BMI = weight / height2) equal to or greater than 30 kg / m2; Present indicative of depression to make up the group of depressed obese; Be between 18 and 60 years of age; Not performing physical activity (self reported) in the last 3 months. Not being on antidepressant medication at the start of the study	Those individuals who present a medical contraindication for the performance of physical activity in the soil and / or water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-2jq3v9	Safety and efficacy in the treatment of vitreous floaters with ophthalmic laser	Recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2506	Safaey and efficacy in ND-Yag laser vitreolysis for symptomatic vitreous floaters: a prospective randomized trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-11-01	Instituto de Assistência Médica ao Servidor Público Estadual - SP	Instituto de Assistência Médica ao Servidor Público Estadual - SP	https://ensaiosclinicos.gov.br/rg/RBR-2jq3v9	<NULL>	Symptomatic Weiss ring (due to posterior vitreous detachment); Symptoms for at least 6 months; Posterior vitreous detachment documented in clinical examination and ocular ultrasound (B-scan); Weiss ring located at least 3mm from the retina and 5mm from the lens, if phakic; If  both eyes are symptomatic, only one will undergo the procedure	Patients unfit for, or refusing to, sign the ICF; Associated diseases that may compromise data analysis; Visual acuity in the other eye worse than 20/50; History of retinal detachment, uveitis, macular edema, glaucoma and aphakia in the studied eye	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-43hccm	Heart Rate Variability and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2507	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-43hccm	<NULL>	The patient should be aged between 20 and 59 years old and be a kidney transplantation patient for at least six months. Patients should be attended in University Hospital of Federal University of Maranhão, have a medical record number, systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively, serum hemoglobin greater than 9 g / dL, glycated hemoglobin (HbAlc) less than 11 percent and be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease, congestive heart failure, active coronary disease and recent acute myocardial infarction and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-93q4gm	Evaluation of how the understanding of oral health influences the use of fluoride toothpaste	Recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2508	Evaluation of the influence of the oral health literacy level in the execution of preventive measures considering rational use of fluoride: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Cristiane Meira Assunção	Fernanda Morais Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-93q4gm	<NULL>	All parents or responsible for children attended at Ambulatory of child at risk from UFMG Clinics Hospital (ACRIAR), during the period of study data collection will be eligible to take part of this study. Parent or responsible that is able to read, has Portuguese as mother language and sign the written consent.	Parent or responsible who as any cognitive impairment, visual and/or auditive impairment, signs of alcohol or drugs effect. Parent or responsible who were able to perform the correct dosage of fluoride toothpaste before researcher advice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-6msdqt	Changing the traumatized patient&apos;memory with Prolonged Exposure Therapy	Data analysis completed	Intervention	2019-03-04	<NULL>	<NULL>	2509	Post-exposure retrieval in the traumatized patient	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-15	Fundação de Amparo à Pesquisa do Estado de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6msdqt	<NULL>	Meet the DSM-IV criteria for PTSD according to the Structured Clinical Interview for DSM Axis I Disorders, Patient Edition (SCID-I/P); being able to report the traumatic event; have emotional reactivity to trauma recall, defined as a minimum score of 40 in the Visual Analogue Scales (VASs) after describing the traumatic event; have regular menstrual cycle (female patients who were then tested in the follicular phase, defined as the first half of their usual cycle) or were taking hormonal contraceptive.	Patients were excluded if they had any medical condition that could threaten their safety, such as heart or neurological conditions, or current suicide risk; fulfill criteria for bipolar, psychotic, or substance use disorders; were in use of medications known to affect memory reconsolidation or extinction, such as beta-adrenergic blockers, benzodiazepines and anticonvulsants; current pregnancy; and previous participation in another study that could affect the present one.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-68bwkc	Application of antimicrobial gel aiming to treat periodontal disease (gingival disease)	Data analysis completed	Intervention	2018-09-14	<NULL>	<NULL>	2510	Clinical evaluation of metronidazole semi-solid and film-forming formulations for the treatment of periodontal disease	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2015-05-05	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-68bwkc	<NULL>	Chronic periodontitis with a clinical insertion level equal to or greater than 5 mm in two or more teeth and depth of probing equal to or greater than 5 mm in one or more periodontal sites (MACHTEI et al., 1992); age range from 35 to 70 years; not have used antibiotics for at least 3 months; absence of history of allergy to the components present in the formulations tested.	"Volunteers with severe cardiovascular disease;
volunteers with problems related to pharmacokinetics, such as nephropathies, liver diseases, etc."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-72k6br	Visual feedback and gait training in novice runners	Recruitment completed	Intervention	2019-03-07	<NULL>	<NULL>	2511	Influence of visual educational and gait biomechanical strategies for prevention of injury-related risk factors in novice runners.	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Santo Amaro	Universidade Santo Amaro	https://ensaiosclinicos.gov.br/rg/RBR-72k6br	<NULL>	Runners must have one year running experience; have a weekly volume of 20 km; have long distance running experience; have a running pattern of rearfoot and a history of injury to the knees and / or feet.	Presence of traumas or fractures of the lower limbs in the last 6 months, have limb length difference of at most 1 cm and have no other musculoskeletal disorders, such as: neuropathies, obesity, rheumatoid arthritis and spurs. Possessing prostheses and orthoses in lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5w75zx	Heart Rate Oscillation in Children with Obesity after Treatment with Video Games and Exercises	Recruiting	Intervention	2019-03-07	<NULL>	<NULL>	2512	Heart rate variability of overweight children after intervention with Exergames	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-27	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5w75zx	<NULL>	Children from 6 to 11 years of age; male and female sex; with diagnosis of overweight and obesity	Children younger than 6 years and older than 11 years, individuals who use drugs that influence cardiac autonomic activity, and those who are carriers of respiratory or metabolic diseases diagnosed before the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-6vyb3f	Functional, psychosocial and related to the sleep effects of different therapies in TMD: randomized clinical trial	Recruiting	Intervention	2019-03-07	<NULL>	<NULL>	2513	Functional, psychosocial and related to the sleep effects of different therapies in temporomandibular dysfunctions: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-12	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6vyb3f	<NULL>	Positive diagnosis for TMD performed through RDC / TMD (Research Diagnostic Criteria for Temporomandibular Disorders)(DWORKIN; LERESCHE, 1992); last treatment for TMD with a minimum interval of 3 months; report of pain in the orofacial region in the last 3 months.	Impairment of cognitive ability, being unable to understand the questionnaires questions; history of head trauma related to the etiology of orofacial pain confusing the TMD diagnosis; intracranial disorders or headache; use of medications in the last 3 months that interfere with sleep quality such as muscle relaxants, anticonvulsants, antidepressants and anxiolytics; use of medication to treat TMD or muscle pain; other causes of orofacial pain such as caries, periodontal diseases, or neuropathies and fibromyalgia. pregnant or lactating patients, in recovery from myocardial infarction, or cardiac arrhythmias, congestive heart failure, cardiac block, or other conduction problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-75h3nz	Effects of scapula exercises in patients with Fracture of the distal radius	Data analysis completed	Intervention	2018-02-06	<NULL>	<NULL>	2514	Effectiveness of adding scapular control exercises to kinetic treatment in patients with distal radius fracture: Randomized simple-blind clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidad de las Americas	CDT Hospital San Borja de Arriaran	https://ensaiosclinicos.gov.br/rg/RBR-75h3nz	<NULL>	subjects over 60 years of age derived from the Adult Traumatology Service of the San Borja Arriarán Clinical Hospital, with a medical diagnosis of multifrectional extraarticular type FRD according to the AO classification, treated conservatively with closed reduction plus immobilization with plaster. Subjects that accept and sign informed consent.	Subjects presenting some immediate complication after removal of immobilization , painful regional complex type I, carpal tunnel syndrome, etc. subjects presenting a shoulder pathology diagnosed at least 1 year before the occurrence of the DRF, subacromial pinching syndrome, partial or total rupture of the rotator cuff, glenohumeral instability, adhesive capsulitis, etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-789tps	Translation and Validation of Pregnancy Mobility Index for Brazilian version	Recruiting	Observational	2019-03-11	<NULL>	<NULL>	2515	Translation, Transcultural Adaptation, Validation and Reproducibility of the Pregnancy Mobility Index for the Brazilian version	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-04-13	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-789tps	<NULL>	Pregnants with a gestational age of more than 12 weeks attended by Victor Ferreira do Amaral Maternity (MVFA); capacity for communication and understanding preserved; without distinction of color / race / ethnicity and sexual orientation and gender identity	Do not fit as volunteers high-risk pregnant women; with psychiatric and/or neurological disorders; and unable to respond to the instruments (illiterate and with speech/writing disorders) or unable to pass the tests that will be applied	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-3ppmcw	Phone calls for guidelines on Insulin Application	Not yet recruiting	Intervention	2019-03-11	<NULL>	<NULL>	2516	Phone Support in the Application of Insulin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3ppmcw	<NULL>	"The study will include those
have an age equal to or greater than 18
years; patients with a diagnosis of
Diabetes mellitus for at least 2 years
associated or not with arterial hypertension; use of insulin; have a fixed telephone line or a cellular telephone for personal use."	Cognitive deficit reported by the participant or family member that makes it impossible to respond directly to the instruments of data collection, if it is a health professional who applies insulin and reports having a hearing or speech problem.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5jy777	The paternal influence on the outcomes of a nutritional intervention conducted in overweight pregnant women	Recruiting	Intervention	2019-03-11	<NULL>	<NULL>	2517	The influence of paternal characteristics on the anthropometry of the newborn of overweight pregnant women in a clinical trial of a nutritional intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Centro de Saúde Escola - Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5jy777	<NULL>	Partners, aged 18 years and older, of pregnant women included in the intervention study, will be invited to participate in the present investigation. Thus, the criterion of inclusion of the study is to be a partner of a pregnant woman included in the nutritional intervention.	As an exclusion criterion will be adopted partners under 18 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-3vzvbx	Effectiveness of Atraumatic Restorative Treatment (fillings) and Ultra Conservative Treatment (brushing) for Dental caries in children	Data analysis completed	Intervention	2019-03-13	<NULL>	<NULL>	2518	Effectiveness and acceptance of Atraumatic Restorative Treatment (ART) and Ultra Conservative Treatment (UCT) for Dental caries in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-08	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3vzvbx	<NULL>	Children from first to fourth year at elementary school; 4 to 9 years-old; presenting at least one primary molar with cavitated dentin caries.	Non cooperative children; children using fixed orthodontic appliance; teeth with any sign of pulp involvement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-7fzqbj	Movement Learning in children and adolescents living in shelters for a Computer Task	Recruitment completed	Intervention	2019-03-13	<NULL>	<NULL>	2519	Motor learning in individuals institutionalized by Task of Timing Coincident	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7fzqbj	<NULL>	non-institutionalized and Institutionalized individuals; age group 6 to 16 years; signing of the consent term; signing of the assent term; individuals with reading and writing skills.	Individuals with physical deficits, cognitive and visual.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5hncs9	Evaluation of the effects of Elastic Stockings on quality of life and prevention of Swelling in the Lower Limbs of hairdressers after a working day	Data analysis completed	Intervention	2019-03-13	<NULL>	<NULL>	2520	Evaluation of Elastic Stocking in quality of life and prevention of Occupational Edema in hairdressers	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-25	Faculdade de Tecnologia e Ciências - FTC	Faculdade de Tecnologia e Ciências - FTC	https://ensaiosclinicos.gov.br/rg/RBR-5hncs9	<NULL>	Prolonged standing period (on average 8 hours); women; accept participating in the study; belong to classes C0 and C1 in the CEAP classification	Disagree in participating in the study; being in use of medication that could influence the formation of lower limb edema; cardiac insufficiency; renal insufficiency; hepatic insufficiency; thyroid disease; rheumatic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-9vk7gt	Treatment of hypersensivity in pacientes with Molar-Incisor Hypomineralization	Recruiting	Intervention	2018-10-23	<NULL>	<NULL>	2521	Hypersensitivity of individuals with molar-incisive hypomineralization - randomized controlled clinical study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade federal do Piauí	Universidade federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-9vk7gt	<NULL>	Volunteers with MIH; with moderate or severe dentin hypersensitivity; from 8 to 12 years; attended at the Children&apos;s Clinic of the UFPI Dentistry Course.	Children with special syndrome or need; imperfect amelogenesis; presence of caries in the first permanent molars; who use fixed orthodontic appliance; who present with gingival recession; who have used desensitizers for three months or less who have used analgesics during 8 h prior to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-8f5mny	The effects of electrical stimulation on the scalp in painful shoulder post-stroke rehabilitation.	Recruiting	Intervention	2017-10-11	<NULL>	<NULL>	2522	The effects of Transcranial Stimulation Direct Current (tDCS) on painful shoulder rehabilitation after stroke - clinical study, controlled, randomized, double-blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8f5mny	<NULL>	Adults over 18 years of age; Diagnosed with chronic stroke and complaint of shoulder pain after stroke for at least six months and be able to understand the commands evaluated by the Mini-exam of the metal state (score&gt; 11).	Contraindications to the use of non-invasive brain stimulation by metal implants near the application site; case history of seizure or epilepsy; skin infection at the application site; gestation or diagnosis of neoplasia; excessive spasticity with scores greater than 3 indicated by the modified ashworth scale on both elbow, wrist or phalangeal flexors of the affected limb; case history of progressive neurological disease; diagnosis of acute coronary syndrome, patients with severe cardiac events with scores greater than 3 indicated by the New York Heart Association functional classification; frozen shoulder diagnosis; suspicion or confirmation of recent fracture in upper limbs; diagnosis of cancer or in palliative care therapy; recent use of botulinum toxin injection in the upper limb affected in the last 3 months or need for its use during the study period; recent use of phenol injection in affected upper limb in the last 6 months or need for the use during the study period; severe sensory deficits with scores less than 2 indicated by the National Institutes of Health Stroke*; severe aphasia with scores greater than 2 assessed in the native language of the patient indicated by the National Institutes of Health Stroke; severe neglect with scores greater than 2 indicated by the National Institutes of Health&apos;s Stroke scale*; use of medications that may interfere with assessments as steroidal anti-inflammatory drugs; individuals who perform physical or homeopathic therapy during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-649bhb	Effectiveness Evaluation of a Comprehensive Care Model in Oral Health for Pregnant Women in Gestational Outcomes: Randomized Clinical Trial	Data analysis completed	Intervention	2019-03-14	<NULL>	<NULL>	2523	Validation of a Comprehensive Care Model in Oral Health for Pregnant Women and Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-649bhb	<NULL>	"Pregnant women registered in e-sus of the municipality&apos;s Basic Health Units in the study;
Have time to participate in the meetings determined during the research;Be in the first trimester of pregnancy (0 to 13 weeks) or in the first prenatal visit of the second trimester (14 to 26 weeks) during the recruitment period;Be accompanied by the Family Health team (eSF) during prenatal care at UBS."	Pregnant women with psychiatric problems;Pregnant women with HIV and / or autoimmune diseases;Pregnant women who use illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-3jytw8	To determine the oxygen saturation levels (SaO2) of the pulp of permanent molars of adult patients who will need to perform direct pulp capping due to pulpal caries exposure, through pulse oximeter evaluation before and after treatment with MTA or glass bioactive 45S5.	Recruiting	Intervention	2019-03-15	<NULL>	<NULL>	2524	Determination Of Pulp Oxygen Saturation In Molars Of Patients Submitted To Direct Pulp Capture With MTA Or Bioative Glass 45S5: Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-07	Centro Universitário do Maranhão- Uniceuma	Centro Universitário do Maranhão- Uniceuma	https://ensaiosclinicos.gov.br/rg/RBR-3jytw8	<NULL>	Patient volunteering to participate in the study, in the age group of 18 to 40 years. Presence of upper and lower permanent molars and premolars with carious lesion. Patient with no history of night pain or spontaneous pain. Pulpal sensitivity to cold test with positive response. Radiographic examination showing deep caries with an image suggestive of proximity to the pulp chamber without signs of periapical pathology. Systemically healthy patient. Patient should have the first, second or third premolar or molar contralateral to the tooth that will be performed sound CPD, as it will be considered the control.	Presence of pain.Teeth affected by trauma. Teeth with color changes; teeth with periodontal changes pocket more than 3mm; mobility and gingival edema; presence of pain on apical palpation; vertical and horizontal percussion; and teeth with pulp necrosis. Teeth with extreme  persistent pain in response to pulp sensitivity test with cold and exposure to iatrogenic pulp.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-7n496r	Effect of acute consumption of juçara juice in damage indicators caused by free radicals and inflammation before and after exercise and the relation with depressive symptoms and anxiety	Data analysis completed	Intervention	2019-03-15	<NULL>	<NULL>	2525	Effect of acute consumption of juçara juice (Euterpe edulis Martius) in oxidative stress biomarkers and inflammatory profile before and after a high-intensity interval exercise session and the relation with depressive symptoms and anxiety: a randomized single-blind cross-over trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7n496r	<NULL>	Male; age between 19 and 30 years; and physically active	Sedentary individuals; smokers; carriers of any diseases, visible or known inflammatory or infectious processes; muscleskeletal injuries in the last 3 months; users of vitamin and mineral supplements, ergogenic resources (carnitine, arginine, creatine and caffeine), anabolic steroids or medications in the month prior to the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-8qxbrg	Motor development in children exposed to social risks in the family	Recruitment completed	Observational	2019-03-15	<NULL>	<NULL>	2526	Psichomotor Development in children with Family Risk	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade do Oeste Paulista- UNOESTE	Universidade do Oeste Paulista- UNOESTE	https://ensaiosclinicos.gov.br/rg/RBR-8qxbrg	<NULL>	children from 0 to 5 years old; both sexes; enrolled in a public education institution; live in a family environment; signature of the Consent term.	diagnosis of changes in psychomotor development.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5tyrtt	Alteration of kidney function in patients undergoing video surgery	Recruiting	Intervention	2019-03-15	<NULL>	<NULL>	2527	Variations in NGAL (Neutrophil Gelatinase-Associated Lipocalin) in patients submitted to pneumoperitoneum with low and standard pressure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Santa Casa de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5tyrtt	<NULL>	Imageological diagnosis of cholelithiasis; formal indication of cholecystectomy; age between 18 and 60 years; both sexes.	Acute pancreatitis; acute cholecystitis. Presence of baseline chronic kidney disease (estimated creatinine clearance by the Cockcroft-Gault equation &lt;90).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-29xb94	Use of Topical Anesthetic Cream for pain relief caused by the injection of Spinal Anesthesia in elective cesarean sections	Not yet recruiting	Intervention	2019-03-15	<NULL>	<NULL>	2528	Use of 2.5% Lidocaine cream and 2.5% Prilocaine cream for analgesia pre lombar puncture of subaracnoideo blocking in programmed cesarians	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Financiamento Próprio	Financiamento Próprio	https://ensaiosclinicos.gov.br/rg/RBR-29xb94	<NULL>	Female patients; over 18 years; pregnant women (above 37 weeks); physical status ASA II; to be submitted to subarachnoid anesthesia for elective cesarean surgery.	"Will not be included in the study: Patients who refuse to participate in the study; patients in labor; who are taking any sedative, opioid or sleep inducing drugs; who have a history of allergy to any drug to be used in the study; severe obesity (defined by a BMI of more than 35 kg.m2), methemoglobinemia, carriers of pathologies that cause some cognitive deficit, such as schizophrenia, oligophrenia, severe depression, etc. If this occurs, the patients will be excluded from the clinical trial, but will not suffer harm in their treatment.
Patients who begin labor during the latency period of topical medication, who require cesarean section before completing 60 minutes after application of the patch containing the cream (anesthetic or placebo), who request their exclusion from the study, will be excluded from the study. study during their performance, who present an allergic reaction during anesthesia or who present partial or total failure of the anesthetic block."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-9y4z7z	Use of troat pack in orthognathic surgery	Data analysis completed	Intervention	2019-03-19	<NULL>	<NULL>	2529	Efficacy of Oropharyngeal pack in Orthognathic surgery - doble-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-13	Universidade de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-9y4z7z	<NULL>	"Age between 18 and 60 years;
Climbing orthognathic surgery of the jaws;
Physical state (ASA) I or II;
That you have a chance to leave your study participation;"	"• Previous history of nausea and vomiting;
• Previous history of motion sickness and migraine;
• Difficulty in tracheal intubation;
• When it was not possible to collect the data or to apply the proposed methodology;
• Allergy to the drugs proposed in this study;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9w5p8q	Clinical evaluation of restorations using a new resin composite	Data analysis completed	Intervention	2019-03-20	<NULL>	<NULL>	2530	Clinical Evaluation of Class II restorations using a composite resin containing the ormocer monomer. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9w5p8q	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5f6zw4	Temporomandibular joint disorder: structural changes, function and causal factors	Data analysis completed	Observational	2019-03-20	<NULL>	<NULL>	2531	"Temporomandibular disorder: morphological, functional alterations and factors
etiological"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Universidade Estadual de Ponta Grossa	Faculdade Guairacá	https://ensaiosclinicos.gov.br/rg/RBR-5f6zw4	<NULL>	Women 18 to 40 years old who reported at least one (1) of the following signs and symptoms: Referred pain in the temporomandibular joint and / or associated musculature (at least 1 episode in the last 3 months); Limitation or restriction of opening or lateralization of the mouth (lateral excursion) (at least 1 episode in the last 3 months); Pain reported in the mouth opening (at least 1 episode in the last 3 months); Sounds in the joint without pain, but with a recent episode (or at least 1 episode in the last 3 months) of pain or limitation of mouth opening; Sounds in the joint without the presence of pain, but with severity enough to cause concern to the patient or make him seek treatment; Women seeking treatment for temporomandibular dysfunction with confirmed diagnosis; Women with diagnosis of temporomandibular dysfunction, obtained by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD) Axes I and II.	History of facial traumas; history of facial neoplasms; history of facial surgeries; cognitive alterations; neurological changes; use of auxiliary devices for walking and locomotion; presence of rheumatic disease; presence of physical disability; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-7trttf	Effects of baru oil supplementation on body composition, inflammation, oxidative stress, lipid profile and blood fatty acids of hemodialysis patients	Recruitment completed	Intervention	2019-03-20	<NULL>	<NULL>	2532	Effects of exercise and nutritional intervention on functional capacity, nutritional status, health perception and quality of life of hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Goiás	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-7trttf	<NULL>	Chronic renal patients undergoing adequate hemodialysis treatment (Kt / V superior at 1.2), via arteriovenous fistula, of both sexes, aged between 25 and 70 years.	Patients with a history of acute myocardial infarction in the last six months; recent hospitalization (less than three months from the start of the study), decompensated diabetes, presence of thyroid dysfunction, patients with acute infections and patients who presented food intolerance to baru or allergy to any oilseed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-25zx8q	Pilates Method Versus Stretching in neuromuscular variables	Recruitment completed	Intervention	2019-03-20	<NULL>	<NULL>	2533	Comparison of the Pilates method and stretching in the neuromuscular variables in women with lombar pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Faculdade de Filosofia e Ciências- UNESP	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-25zx8q	<NULL>	Volunteers with chronic low back pain; female; aged between 17 and 33 years.	Neurological symptoms; discrepancy between limbs greater than two centimeters; ankylosing spondylitis; rheumatoid arthritis; disc herniation; tumor; infection; vertebral fracture; cauda equina syndrome; cardiovascular or cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-8zzwfn	Use of Virus-Specific Lymphocytes for Treatment of Patients with Low Immunity After Bone Marrow Transplantation	Not yet recruiting	Intervention	2019-03-20	<NULL>	<NULL>	2534	Expansion of virus specific lymphocytes for cell therapy in immunosuppressed patients submitted to bone marrow transplant	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-03-01	Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein	Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-8zzwfn	<NULL>	Patients of both sexes. Patients who have undergone allogeneic bone marrow transplantation. Patients who have cytomegalovirus infection or reactivation without clinical improvement or CMV copy decline after at least 2 weeks of treatment with standard anti-viral therapy.	Patients who have received ATG, Campath or other immunosuppressive monoclonal antibody in less than 28 days. Patients who have received infusion of donor lymphocytes in less than 28 days. Patients with other uncontrolled infections than cytomegalovirus. Patients with Grade II to IV active graft versus host disease (GVHD). Patients receiving corticosteroid therapy with equivalent or higher doses of prednisone 0.5mg/kg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-4493ct	Clinical Evaluation of Ceramic Restorations Glued to the Tooth	Not yet recruiting	Intervention	2019-03-21	<NULL>	<NULL>	2535	Clinical Evaluation of Ceramic Facets Luting with Ceramic Self-Etch Primer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4493ct	<NULL>	Patients older than 18 years, patients with indication for dental contact lenses or ceramic facets, at least from canine to canine, who accept the terms of the research.	Patients smokers, pregnant or lactating, patients with high risk of caries and / or periodontal disease, or patients with some systemic deficiency that prevents periodic monitoring.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-33k97n	Laboratory and clinical evaluation of a resin restorative system without bisphenol a used for gluing orthodontic brackets	Recruiting	Intervention	2019-03-21	<NULL>	<NULL>	2536	In vitro and in vivo evaluation of a resin restorative system bisphenol a free used for fixation of orthodontic brackets	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-19	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-33k97n	<NULL>	Age between 12 and 20 years; without gender preference; with complete permanent dentition; without lesions of caries and or periodontal disease; nonsmokers who will start treatment with fixed orthodontic appliances at the Orthodontics Specialization Clinic of the School of Dentistry of Ribeirão Preto USP; Patients should be good general health; have not received restorations in composite resins and or sealants in the last three months and do not engage in occupations that may be linked to BPA exposure.	Patients who are not in the criteria described in the inclusion; Patients who have received restorations in composite resins and or sealants in the last three months; and patients who have occupations related to BPA exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-84r7t9	The autonomic balance in asthmatic children	Data analysis completed	Intervention	2019-03-21	<NULL>	<NULL>	2537	The autonomic nervous system in asthmatic children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Programa de Pós-graduação em Ciências da Saúde- PPGCS-FURG	Hospital Universitário Dr. Miguel Riet Corrêa Jr. - HU-FURG	https://ensaiosclinicos.gov.br/rg/RBR-84r7t9	<NULL>	"We included all children aged 7
and 18 years old and diagnosed with asthma, attended at the Pneumology outpatient clinic
Pediatric Hospital of the University Hospital of the Federal University of Rio Grande (FURG), in the period between December 2015 and November 2016."	Patients with a diagnosis of bronchopulmonary dysplasia; cystic fibrosis; congenital cardiopulmonary diseases; immunodeficiency; chronic encephalopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-2jfwqx	Change in effort capacity and life quality after pulmonary reabilitation in pre lung trasplantation patients /Clinics Hospital of Universidade Federal de Minas Gerais	Recruitment completed	Intervention	2019-03-25	<NULL>	<NULL>	2538	Chande in six minutes walk test and life quality after pulmonary reabilitation in lung trasplantation patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-18	Hospital das Clínicas UFMG	Hospital das Clínicas UFMG	https://ensaiosclinicos.gov.br/rg/RBR-2jfwqx	<NULL>	"It must be stable from a clinical point of view.
Be motivated to participate in the program.
Be free of lung infection at the time of starting the program.
There must be no other disabling condition limiting your participation in the program.
Must be receiving medical follow-up and release for inclusion in the program."	"Be clinically unstable.
Being unmotivated to participate in the program.
Being with pulmonary infection at the time of starting the program.
Having another disabling condition that limits your participation in the program (musculoskeletal disease that prevents exercise, decompensated heart failure, uncontrolled hypertension).
Not having medical follow-up and release of it for inclusion in the program."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7g6qq8	Comparison of the effects of oral and intramuscular use of corticosteroids on pain, swelling and mouth opening and closing movements after extraction of the wisdom tooth	Data analysis completed	Intervention	2019-03-25	<NULL>	<NULL>	2539	Comparative study of the effectiveness of two routes of corticosteroid administration to control edema, trismus and pain after surgical extraction of impacted third molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-27	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7g6qq8	<NULL>	The inclusion criteria were: healthy subjects, aged over 16 years of either sex, without contraindications for corticoid treatment, no history of pericoronitis for the last 6 months, no history of recent illness that required medications that could alter the inflammatory response, no use of medication that could interfere with the healing process and who required extraction of all four third molars. The extractions were all of similar technical difficulty and orthopantomography showed positioning and depth of impaction to be symmetrical in each arch. All patients required ostectomy and tooth sectioning of the lower third molar to achieve extraction. The difficulty was determined by means of the Pell and Gregory classification.	"Occurrence of post-operative local infection
 Failure to attend second surgical procedure"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-3tknxy	Influence of lemon on the inflammatory activity of healthy women during menstruation	Data analysis completed	Intervention	2019-03-25	<NULL>	<NULL>	2540	Influence of cytotherapy on prostaglandin production in healthy women during menstruation	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2016-06-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3tknxy	<NULL>	Healthy women aged 18-40 years who signed the informed consent form	"Women who used some type of hormonal contraceptive, with a history of gynecological diseases, immunodeficiency, autoimmune diseases, malignant neoplasms or history of chemotherapy or radiotherapy.
Women who practiced intense physical activity or recently modified their physical activity patterns.
Women who used chronic drugs such as non-hormonal anti-inflammatories, immunosuppressants, anxiolytics or antidepressants, or who used some type of medication in the 15 days prior to the start of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-4g23g5	Impacts of Hormone Therapy on Transgender Women and Transvestites with HIV: A Cohort Study	Recruiting	Observational	2019-03-26	<NULL>	<NULL>	2541	Effects of hormone therapy in HIV-positive transgender women and travestis or those at high risk for infection: a cohort study	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-4g23g5	<NULL>	People assigned male sex at birth who identify as transgender women, transvestites, or a gender other than male; age 18 or older; documented Human Immunodeficiency Virus (HIV) infection; history of risky sexual behavior in the last 12 months, including: acquisition of a Sexually Transmitted Infection (STI); report of unprotected anal/neovaginal intercourse; difficulty negotiating condom use	Any condition of the volunteer that, in the opinion of the investigator, may make her participation unsafe, complicate the interpretation of the study data or interfere in the study objectives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-5xpg6j	Effects of myofascial release and stretching  on ankle mobility on healthy runners	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2542	Effects of myofascial release and static stretching on ankle dorsiflexion range of motion in healthy runners: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-18	Departamento de Ortopedia e Traumatologia da Universidade Federal de São Paulo	Thiago Costa Buran	https://ensaiosclinicos.gov.br/rg/RBR-5xpg6j	<NULL>	Healthy runners both male and female; pratice running minimum 2 times per week; age between 18 and 45 years old; no history of trunk or lower limb injury in the last 6 months.	Participants presenting pain due to one of the intervention; start some physical activity during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-89mdvw	Exercise therapy to prevent Mandibular Hypomobilit in patients with Head and Neck Cancer undergoing Radiation Therapy	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2543	Exercise Therapy to prevent Radiation-induced Trismus in Head and Neck cancer Patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-20	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-89mdvw	<NULL>	either sex; age 18 years or more; formal histopathological diagnosis of oral or oropharynx cancer; undergoing radiotherapy alone or as adjunct to surgery or chemotherapy.	motor sequelae affecting the upper extremities, face or neck region, whether secondary to stroke, facial palsy; trigeminal neuralgia; trauma or surgery that precluded completion of the exercise protocols; cognitive impairments, such as Alzheimer’s disease; senile dementia; and Wernicke-Korsakoff syndrome; history of prior radiotherapy to the head and neck region; history of surgical interventions involving resection of the mandible; current physical therapy or speech pathology interventions for trismus; initial moth opening smaller than 10 mm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-3zmh3r	Effects of the inclusion of a Functional Circuit to Aerobic and Resistance Training on functionality, physical activity in daily life and inflammation of patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	2544	Effects of the inclusion of a Functional Circuit to Aerobic and Resistance Training on functionality, physical activity in daily life and immuno-metabolic response of patients with Chronic obstructive pulmonary disease (COPD): a randomized clinical trial with follow up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Julio de Mesquita Filho - UNESP	Ercy Mara Souza Ramos	https://ensaiosclinicos.gov.br/rg/RBR-3zmh3r	<NULL>	patients diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD); clinically stable patients without exacerbations or changes in medications for at least 30 days; they are not smokers; patients who do not undergo home oxygen therapy;  patients without pathological conditions that prevent physical activity; no severe or unstable heart disease diagnosed by electrocardiogram; does not present any other pathological condition that may influence the systemic inflammatory process; not participating in another systematic exercise program.	Exacerbations or intercurrences that prevent the continuity of the training protocol; frequency of less than 75% of the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9jkmq7	Impact of new Complete Dentures on quality of life and chew in institutionalized elders	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2545	Impact of Complete Dentures on quality of life and masticatory performance in institutionalized elders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9jkmq7	<NULL>	Elderly with 60 years of age or older; fully edentulous	physical and mental limitations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9tpwc5	The effect of Conventional Transcutaneous Electric Nerve Stimulation (TENS) for treatment of Migraine crisis	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	2546	The effect of Conventional Transcutaneous Electric Nerve Stimulation for treatment of Migraine crisis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-10	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9tpwc5	<NULL>	"The selection of patients will be carried out based on electronic medical record research and routine consultations in the head and face ambulatory, following the &quot;Guidelines for clinical trials of drug in migraine&quot; (IHS, 2012). Patients with a diagnosis of primary headache classified as migraine will be included; And the major subtypes: migraine with aura and migraine without aura; (ICHD-III, 2013), respecting the following criteria:

Migraine without aura: recurrent cephalic disorder in at least five episodes with the following characteristics: duration of 4 to 72 hours, unilateral, pulsatile, moderate or severe intensity, aggravation by routine physical activity and association with nausea and / or photophobia and phonophobia ;Migraine with aura: at least five episodes with features of migraine without aura and preceded or accompanied by neural symptoms. The typical aura occurs from 5 to 60 minutes duration before the onset of pain, unilateral and completely reversible, with visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by Headaches with migraine characteristics and associated symptoms. It can be of six different types, namely retinal aura, visual aura, sensory-somesthetic aura, motor aura, aphasic aura and brainstem aura.
The study will invite patients of both genders, aged between 18 and 65 years, age at onset of illness less than 50 years, diagnosed with migraine for at least one year before being recruited to participate in the study. All should be in current treatment with the use of recommended medicines, in stable doses for at least 30 days and that present sporadic crises.The use of these recommended drugs in the literature and guidelines for the prevention of migraine will occur in conventional doses. All predicted classes of drugs may be employed, namely: calcium channel blockers, such as nimodipine, beta-blockers, such as propranolol and atenolol; Tricyclic antidepressants, such as amitriptyline and nortriptyline; And, among the anticonvulsants, only topiramate and sodium valproate. The frequencies of migraine attacks (with the use of the recommended treatment and in stable doses) should be 1 to 6 times a month, with a remission period of at least 48 hours (IHS, 2012)."	"Patients with the following criteria will be excluded from the sample: Physical or intellectual incapacity to respond to the survey questionnaire, illiterate, diabetic, pacemaker, epileptic, users of illicit substances and those diagnosed with other CNS diseases (IHS, 2012). Other classifications of migraine, such as chronic migraine (over 15 days with headache / month) and overuse of medications, eg, more than 10 days in the use of triptans for acute pain (IHS, 2012).
Ethical patients, ie the acceptable consumption of alcoholic beverages is up to 15 doses / week for men, not exceeding three daily doses and 10 doses / week for women, no more than two doses per day (WHO, 2004)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9yrydw	Effect of laser on shoulder tendinitis	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	2547	Effects of photobiomodulation therapy on repair of rotator cuff tendinopathy of the shoulder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9yrydw	<NULL>	Rotator cuff lesion grades I and II in the Neer classification; both sexes; age from 18 to 70 years; have signed the informed consent form (TCLE); subacromial pain for at least three months; two of the three positive impact tests (Jobe, Hawkins and Neer).	History of shoulder dislocation and seizure test for positive displacement; intratendine calcifications of the rotator cuff; presence of a proximal humerus anterior fracture; previous surgery on the shoulder; clinical and imaging diagnosis of total rupture in the shoulder rotator cuff tendon; adhesive capsulitis of the shoulder; acronym type III classification of Bigliani on X-ray; use of corticosteroid infiltrations three months prior to the study; presence of rheumatic and neurological diseases; pregnancy; be performing some type of therapeutic intervention for the shoulder in some other service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-2xx2r2	Treatment Program for Chronic Pain	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	2548	Rehabilitation Program in Individuals with Chronic Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade do Estado de Santa Catarina	Prefeitura Municipal de São José	https://ensaiosclinicos.gov.br/rg/RBR-2xx2r2	<NULL>	History of low back pain in the last six months and pain intensity igual ou maior que 3 (Numeric Pain Rating Scale - NPRS) on movement in at least one direction (flexion, extension or rotation).	Previous history of rheumatic disease, lumbar myelopathy, tumors, central or peripheral neurological disorders; history of major trauma, fracture or surgery in the lumbar region; signs of nerve root compression such as: major muscle weakness affecting the lower limb, decreased or abolished patellar and calcaneal reflexes, and decreased sensitivity in the lower limb dermatomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-3hj4ny	Effects of baru oil or mineral oil supplementation on the bowelfunction of hemodialysis patients	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2549	Effects of exercise and nutritional intervention on functional capacity, nutritional status, health perception and quality of life of hemodialysis patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Goiás	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-3hj4ny	<NULL>	Chronic renal patients in an adequate hemodialysis treatment (Kt / V greater than 1.2), via arteriovenous fistula, of both sexes, aged between 25 and 70 years and who did not use laxative.	Patients with a history of acute myocardial infarction in the last six months; recent hospitalization (less than three months from the start of the study), decompensated diabetes, presence of thyroid dysfunction, patients with acute infections and patients who presented food intolerance to baru or allergy to any oilseed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7jz7hm	Evaluation of the efficacy of topical treatment with tetracycline in the prevention of cutaneous loxoscelism	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	2550	Effectiveness of the use of topical Tetracycline in cutaneous Loxoscelism	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-10-01	Fundação de Amparo a Pesquisa do estado de São Paulo	Instituo Butantan	https://ensaiosclinicos.gov.br/rg/RBR-7jz7hm	<NULL>	"Patients who are victims of skin loxoscelism treated in the State of Santa Catarina will be selected and contacted by the health team and the Toxicological Assistance and Information Center (CIATox-SC) before starting any specific therapy, considering the following diagnostic criteria:
Typical cutaneous lesion, characterized by the presence of a livedoid (marmoreal) plate, surrounded by ischemic halo, accompanied or not by perilesional blisters, ecchymosis and / or endemic edema, accompanied or not by systemic manifestations;
2. Atypical cutaneous lesion with suggestive clinical history, excluding other differential diagnoses, with visceral manifestations characterized by hemolysis (to be confirmed by anemia associated with reticulocytosis, elevated bilirubin and LDH), fever, hematuria/hemoglobinuria;
3. Suggestive history, being the spider captured and the genus identified by CIATox-SC.

Sample size
Patients will be randomly divided into two groups: conventional treatment (control) and experimental treatment, in a ratio of 1: 1, for a total of 240 patients.

Inclusion criteria
Consecutive patients, of both sexes, over 18 years old, who signed a free and informed consent form with clinical diagnosis of loxoscelism treated at the health units of the municipalities of Santa Catarina, whose contact for diagnosis and therapeutic orientation be done via telephone with CIT-SC."	Patients who have received or applied any topical treatment for loxoscelism, those who arrive at the service with an indication of surgical procedure of the lesion (debridement of necrotic tissue), as well as the ones who  refer atopy or other allergic conditions arising from the use of tetracycline. Also excluded are those who, after the introduction of therapy, have any adverse effects thereof.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-66nmk2	Influence of a training using Virtual Immersion to improve the memorization process	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2551	Influence of Virtual Immersion in different environments on the consolidation of working memory	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-04	Fundação Universidade Federal do Piauí	Fundação Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-66nmk2	<NULL>	Male subjects, healthy and right-handed, according to the Edinburgh Lateral Dominance Inventory	"0
Presence of any current or past psychiatric, cognitive or behavioral disorders (neurodegenerative, cerebrovascular, traumatic brain injury, etc.) or disorders that could influence cognitive performance; to have a first-degree relative with some neurological disorder; have uncorrected vision or hearing problems; have a history of conditions or factors that may alter physiological signs, such as the use of medications (benzodiazepines), alcohol or illicit drug use; presenting attention deficit hyperactivity disorder; be less than 18 years old or over 28; change in systemic blood pressure and heart rate; participate directly or indirectly in the accomplishment of the present study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-46vshg	Clinical evaluation of the influence of calcium and fluoride  based mouthrinses in reducing tooth sensitivity and the effectiveness of color change during in-office bleaching	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2552	Clinical evaluation of the influence of calcium lactate and fluoride solution mouthrinses in reducing tooth sensitivity and the effectiveness of color change during in-office bleaching	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-46vshg	<NULL>	Including criteria: ageded 18 to 30 year, the presence of at least 20 teeth and presence of elements 13, 12, 11, 21, 22, 23, 33, 32, 31, 41, 42, 43 sound or at most 1/6 restores labial surface.	Exclusion criteria: teeth with initial teeth color assessed by spectophotometer (VITA Easyshade® Advance, Vita, Germany) B1, removable or fixed prosthesis and orthodontic appliances users, pregnant or breastfeeding, smokers, previous dentin sensitivity, generalized gingival retraction or above 2mm, presence of active caries lesions in enamel and dentin, presence of periodontal inflammation and other oral lesions, tetracycline-pigmented teeth and patients who received previous bleaching treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7x7fg2	Correlation of respiratory muscle training with the functional capacity and quality of life of patients with heart failure	Recruitment completed	Observational	2019-03-28	<NULL>	<NULL>	2553	Effects of respiratory muscle training on the functional capacity and quality of life of individuals with heart failure	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7x7fg2	<NULL>	Patients with Heart Failure of functional class III and IV; of both sexes; age between 57 and 80 years; with at least one year of outpatient follow-up with a cardiologist.	Participants with heart failure class I and II; those that are not released by medical evaluation; those who are in clinical follow-up with less than one year of follow-up by the doctor in charge; those with severe pulmonary limitation; those who do not want to participate in the study or leave without the conclusion of the study; those that obtain and exacerbate in the middle of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-54qqz5	Effect of Brazil nut supplementation on the maternal diet under the nutritional profile of human milk	Recruitment completed	Intervention	2019-03-28	<NULL>	<NULL>	2554	Effect of Brazil nut (Bertholletia excelsa) supplementation on the maternal diet under the nutritional profile of human milk	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Departamento de Tecnologia de Alimentos - UFV	Departamento de Tecnologia de Alimentos - UFV	https://ensaiosclinicos.gov.br/rg/RBR-54qqz5	<NULL>	To be included in the research, breastfeeding women should: residing in the municipality of Viçosa, MG; have born newborn term, ie, gestational age between 37 and 42 weeks, healthy, and weight appropriate for gestational age; only breastfeeding; they are producing enough milk and willing to donate the samples for research; Being in the age group between 18 and 40 years; accept participation and sign the informed consent form	Breastfeeding women who interrupt exclusive breastfeeding during the period of study; lack the evaluation; stop collecting the milk sample or present at any time allergy or intolerance to Brazil nuts will be excluded from the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-37v2zt	CAD/CAM metal-free single crowns: a clinical study	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2555	CAD/CAM metal-free single crowns: a controlled randomized clinical study	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-05-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-37v2zt	<NULL>	Participants from 18 to 60 years old; which are indicated for total crowns on posterior permanent teeth; which are available for clinical follow-up throughout the evaluation period; participants willing to pay for laboratory costs; willing and able to undergo periapical / interproximal radiographic examination when necessary; be in accordance with the Informed Consent Form (TCLE); general health consistent with the clinical evaluation period; maxillo-mandibular relationship and occlusal stability.	History of allergy to some of the materials to be used in the research; pregnancy at the beginning of the experiment; use of drugs that may interfere with the oral environment; systemic or malignant diseases at the start of the study; impossibility to be submitted to the specific techniques for conducting the research; insufficient space for proper preparation of crowns; patients with parafunctional habits; pillars that endodontically and periodontally do not show predictability until the end of the evaluation period; periodontal disease; high risk of caries; absence of more than one tooth in the posterior region; unsatisfactory oral hygiene; use of removable partial dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9cvrrs	Brazilian Fruits and Heart	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2556	Brazilian Fruits and Heart	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual Paulista - Câmpus de Marília	Universidade Estadual Paulista - Câmpus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-9cvrrs	<NULL>	"Young adult men from 18 to 30 years;
Apparently healthy; active according to the IPAQ and BMI 18,5 e 29,99 kg/m2"	Individuals with cardiorespiratory; neurological; musculoskeletal; renal; metabolic; endocrine or other reported impairments will not be analyzed to prevent them from performing the procedures; individuals with SBP&gt; 130mmHg and DBP&gt; 90mmHg at rest; smokers; alcoholics; those who are under medication that influence the autonomic nervous system; sedentary and insufficiently active according to the IPAQ.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8r8b6p	Virtual Game for teaching drug preparation and administration	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2557	Virtual Learning Technology for teaching drug  preparation and administration	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8r8b6p	<NULL>	Students enrolled regularly in the university&apos;s nursing course, at semiology, semi-technical and caregiving subject.	Students who have had some personal or professional practice related to preparation and administration of drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-7g4dhr	Effect of physical exercise for the muscles of respiration in the body&apos;s defense system in the elderly	Data analysis completed	Intervention	2019-03-28	<NULL>	<NULL>	2558	Effect of Respiratory Muscle Training on the Immune Response in the elderly	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7g4dhr	<NULL>	Adults older than 65 years of age; of both sexes; who lived in healthy nursing homes and who agreed to participate in the study by signing the ICF.	Elderly patients who did not understand some of the steps of the proposed protocols; with a body mass index above 35 mL / kg²; or with some degree of orthopedic or neurological limitation that made the tests impossible were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-67qgm2	Effects of cold water immersion on clinical, functional and performance parameters in swimming athletes	Recruitment completed	Intervention	2019-03-28	<NULL>	<NULL>	2559	Effects of systematized application of cold water immersion on clinical, functional and performance parameters in swimming athletes - a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-07	Universidade Estadual Paulista	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-67qgm2	<NULL>	"Athlete of the swimming team of SEMEPP (Municipal Secretary of Sports of Presidente Prudente);
Train regularly 6 days a week;
Be aged between 12 and 20 years;
Do not present previous musculoskeletal injury or disease that makes it impossible to train."	Provide injury or illness during the period of research that moves away from training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9nbfsf	Postoperative evaluation of lasting procedures after Laser application in the donor area: a Randomized Clinical Test	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2560	Morbidity postoperarive procedures in Tissue Graft after Laser application of Low Power in donor area: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de Odontologia UFRGS	Faculdade de Odontologia UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-9nbfsf	<NULL>	The following inclusion criteria will be applied when patients are selected: age greater than 18 years; patients requiring connective tissue grafting; systemically healthy patients, without any condition that may influence healing, including but not restricted to decompensated and / or immunodepressed diabetics and coagulation disorders; no smokers or former smokers for at least one year; patients who do not require preoperative antibiotic prophylaxis	During the course of the study the following exclusion criteria will be considered: patients who develop systemic conditions that interfere in healing; patients who start smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8rtzfn	Effects of tens (muscular surface electrical stimulation) on walking distance, function, function of the heart&apos;s nervous system and cardiorespiratory fitness of individuals with Peripheral Arterial Disease: a randomized clinical trial	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2561	Effects of tens on walking distance, functional capacity, autonomic cardiovascular function and cardiorespiratory fitness of individuals with Peripheral Arterial Disease: a randomized clinical trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Minas Gerais	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora - SUPREMA	https://ensaiosclinicos.gov.br/rg/RBR-8rtzfn	<NULL>	To be included he must initially sign the free and informed consent form. There may be no claudicating pain of non-vascular origin; uncontrolled diabetes; uncontrolled hypertension; chronic kidney disease diagnosed; acute myocardial infarction in the last three months; history of recent pulmonary embolism; neuromuscular changes that limit the functional capacity; exercise tolerance primarily limited by factors other than the claudicating symptom and cardiovascular physical therapy in the last three months.	Individuals unable to understand and perform procedures with the measurement is with higher blood pressure (BP) values superior to 200 / 110 mmHg and heart rate (HR) greater than 120 bpm;  and HR &gt; 85% of maximal predicted by age during exercise testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-97hsb9	Motor Development after Swimming Pool Treatment	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2562	Evolution of Psychomotor Development of children after Hydrotherapy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-97hsb9	<NULL>	Children of both sexes; diagnosis of motor development delay; authorization of participation in the study with signature of the consent term; acceptance of the child for research participation by the assent term.	Childrens with three consecutive absences during sessions; infectious diseases, being decompensated cardiac or pneumopathic; visual, auditory, or cognitive deficits that interfere with the evaluation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-2m4jk5	The efficacy of two speech therapy therapies in elderly patients with swallowing disorders  living in nursing homes	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2563	The efficacy of two speech therapy interventions in the elderly living in nursing homes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Pós Graduação em Ciências da Saúde da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2m4jk5	<NULL>	Elderly of both sexes; Brazilian nationality; living in nursing home at the moment of data collect; with dysphagia and with preserved cognitive capacity.	Elderly people with difficulties to understand and execute simple orders; with psychiatric; neurological; neuromuscular or neurodegenerative alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-5nqk4k	Effectiveness of Corrective Insoles in the treatment of Diabetic Foot	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2564	Efficacy of Customized Insoles in the treatment of Diabetic Foot: Randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-05	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5nqk4k	<NULL>	Volunteers over 18 years of age; of both sexes; patients with type 2 diabetes mellitus; carriers of typical diabetic neuropathy; with increased plantar pressure in the forefoot region.	Patients with fasting glycemia below 100 mg / dl and HbA1c below 5.7% in the absence of treatment; patients with movement disorders; previous history of stroke; orthopedic surgeries or ulceration and amputation of lower limbs; pregnant women; patients in whom complete and adequate physical examination was not possible; patients with balance difficulties; patients who can not move alone; patients who have another cause of neuropathy; patients who do not attend for laboratory or non-laboratory tests and who choose to give up the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-55bcbt	Evaluation of Postoperative pain and Success of Tooth Root Treatment of the Quality of Life of patients with and without Type 2 Diabetes Mellitus	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2565	Evaluation of Postoperative Pain and Success of Endodontic Treatment on the Quality of Life of patients with Type 2 Diabetes Mellitus - A Controlled Clinical Trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-55bcbt	<NULL>	Adult patients; with or without diabtes mellitus; with endodontic treatment indication in permanent molars, diagnosed with irreversible pulpitis; have contact number to be able to perform the postoperative evaluations.	Pregnant patients; administering any medication when treatment; immunocompromised; with hypersensitivity to non-steroidal anti-inflammatory drugs; patients who have teeth with endodontic complications (calcifications, external or internal resorption, partial formation of apical summit with dental drilling, with longitudinal or vertical fractures and severe periodontal disease); patients who can not have endodontic treatment completed in the same session; Patients who for any reason can not be contacted by phone for the evaluation of pain after endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-5b9jk7	Nutrition WhatsApp messages to promote healthy eating in adolescents	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2566	mHealth intervention to promote healthy eating among Brazilian adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5b9jk7	<NULL>	Seniors healthy high school adolescents of the Federal District of Brazil; both genders; with expected age between 16 and 18 years; owner of a smartphone	No signature or agreement of participation in the study by the adolescent or his or her responsible person	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9cy6py	Assessment of the implementation of an educational action focused on patients with poor anticoagulation control  in two teaching hospitals	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2567	Assessment of of the implementation of an Educational Intervention focused on patients with poor anticoagulation control using vitamin K antagonist in two teaching hospitals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Federal de Minas Gerais	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9cy6py	<NULL>	Eighteen years of age or more, both sexes, follow up in the anticoagulation clinics for at least six months, valvular or non valvular atrial fibrilation  as indication for warfarin use and time in therapeutic range below the percentage of sixty	Bedridden patients or limitation of locomotion that compromises the attendance to scheduled visits, blind or deaf, aphasia or other speech disorders that could hinder communication during study, dementia diagnosis reported in medical records, less than two international normalized ratio values in the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-6jp2qv	Randomized study of different veins for implantation of pacemaker, defibrillator and resynchronizer cables at Hospital de Clínicas de Porto Alegre	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2568	Randomized clinical trial of venous access routes for cardiovascular implantable electronic devices at Hospital de Clínicas de Porto Alegre	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-19	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6jp2qv	<NULL>	Patients with a pacemaker or defibrillator implant indication (single-chamber, bicameral or resynchronizer) who agree to participate in the study and sign the informed consent form.	Patients presenting clinical conditions that prevent randomization to one of the access routes, namely: central venous thrombosis; patients with previously implanted leads.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-78nwbg	Effects of an online social network on promoting and supporting breastfeeding	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	2569	Effects of an intervention to promote and support for breastfeeding through social maternal online network	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Hospital Universitário Lauro Wanderley	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-78nwbg	<NULL>	Mothers in the postpartum period that use the online social network Facebook; can read and write.	Illiterate mothers; under the age of 18;  seropositive for HIV or other diseases that contraindication to breastfeeding; premature fetuses; low weight; twin; congenital problems to prevent suckling at the breast.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-2gzgys	Evaluation of heart rate in postural changes in people with spinal cord injury	Recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2570	Characterization of autonomic cardiac modulation in the postural transition of sedestation to orthostatism in people with spinal cord injury	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-12	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gzgys	<NULL>	All patients with medical diagnosis of spinal cord injury with conditions to perform the proposed task will be considered eligible. For the control group; people with no neurological impairment matched by sex and age will be eligible, with proper authorization by means of a Consent Form and consent form of both groups.	Patients with cardiac arrhythmias and atrioventricular block; congenital anomalies such as congenital heart diseases; pulmonary malformations and patients using drugs that interfere with ANS; such as antiarrhythmic drugs and drugs for the treatment of diabetes mellitus such as insulin will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-6yy775	The use of the Body using as a therapeutic ally in Speech-Language Clinic: comparative analysis of language and vocal aspects in adults who Stutter - randomized clinical trial	Recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2571	"Psychomotricity and Stuttering in Speech-Language Clinic: Comparative Analysis of Perceptual-Auditory and Acoustic Vocal aspects,
Temporal Processing and Severity in Adults who Stutter - Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-06	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6yy775	<NULL>	"Volunteers aged between 16 and 40 years of age; 
of both genders; previously diagnosed with Developmental Stuttering, with stuttering severity between scores of &quot;Light to Moderate&quot; and &quot;Very Severe&quot;, based on Stuttering Severity Instrument for Children and Adults (SSI-3)"	Volunteers aged out of the proposed; significant behavioral changes; psychiatric and/or cognitive disorders; attend some other type of speech therapy at another institution/clinic during the intervention; or irregular behavior or frequency, which may compromise the accuracy of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8jdbrm	The Neurological and Clinical Effects of Game Therapy in Fibromyalgia Patients	Recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2572	Neurophysiological and clinical effects promoted by Game Therapy in Fibromyalgia: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8jdbrm	<NULL>	The inclusion criteria for the study will consist of clinical diagnosis of Fibromyalgia; female gender; autonomy to perform the exercises; preserved cognitive aspect evaluated through the Mini Mental Status Examination.	Patients who present with uncorrected visual deficit; associated neurological or psychiatric disease; orthopedic or cardiac limiting changes; lose 3 consecutive sessions of the intervention protocol; and changes in medication during the study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8rpmcg	Body Composition and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2573	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rpmcg	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-46ttz5	Renal Function and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2574	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-46ttz5	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-2vd7nb	Iron deficiency anemia in cancer patient: proposal of a new treatment	Recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2575	Iron deficiency anemia in oncological patient: proposal for the implementation of a teatment protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-2vd7nb	<NULL>	Patients 18 years of age or older; diagnosis of solid malignancies detected in an anatomopathological examination; presenting hemoglobin levels below 12 g / dl in females or 13 g / dl in males	Pregnant patients; in palliative care; with previous history of hypersensitivity to any of the iron formulations of this study; lack of adequate venous access to the infusion of the drug; refusal to continue the indicated supplementation; worsening of the oncological condition that compromises the response to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-76gtyz	The influence of proprioceptive insoles associated with acupuncture in women	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2576	The influence of acupuncture-associated proprioceptive insoles on balance, posture, muscle activity, flexibility and energy profile of meridians in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-25	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-76gtyz	<NULL>	University students, female; age between 18-30 years; sedentar;have access to Whatsapp; application for smartphones; in order to facilitate the communication.	Students who present S scoliosis; uncorrected vestibular; auditory and ocular alterations; recent fractures in the lower limb; prosthesis in the lower limb; pregnant women; BMI&gt; 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-6pt9xt	Ultrasound associated with electric current in the treatment of localized fat in the abdomen	Recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2577	Combined Therapy in Abdominal Adiposity treatment: randomized control trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-11	Centro Universitário CESMAC	Raphaela Farias Teixeira	https://ensaiosclinicos.gov.br/rg/RBR-6pt9xt	<NULL>	Women; between 20 and 40 years old; who complain of fat localized in the abdominal region; classified as normal weight or overweight by Body Mass Index (BMI) (BRASIL, 2011); who are not performing any esthetic treatment.	Women who exhibit sensitivity disorders; dermatological alterations; allergies to the active principles of the gel; and / or any condition that contraindicate the use of therapeutic resources; or who are pregnant, will be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8kkh26	Dance Program for Older Adults	Not yet recruiting	Intervention	2019-01-03	<NULL>	<NULL>	2578	Effects of Dancing on Physical-Functional Fitness, Cardiometabolic Profile, Cognition and Quality of Life of Older Adults: a Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Hospital Universitário Onofre Lopes – HUOL	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-8kkh26	<NULL>	Both sexes; age equal or superior to 60 years; fit for physical exercise; pharmacological plan unchanged in the last 4 weeks; agreeing to participate in any of the groups; not participating in a regular exercise program in the last 3 months	Not signing the consent term; history of cardiovascular diseases or events; limiting chronic lung disease; chronic kidney disease requiring dialysis; uncontrolled hypertension; diabetes in use of insulin or decompensated; high alcohol consumption; uncorrected limitations of language, hearing or sight; contraindication for exercise, shown in the cardiopulmonary exercise test; cognitive impairment according to the MEEM and/or RAVLT tests; progressive neurological disorders; cancer requiring treatment in the last two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8zzfzn	Evaluation of efficacy and safety of Penetro solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in adults	Not yet recruiting	Intervention	2019-04-02	<NULL>	<NULL>	2579	Evaluation of superiority on efficacy and safety of Penetro solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in adult population: a phase III, national, multicenter, double blind and randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-01	CAEP - Centro Avançado de Estudos e Pesquisas	Synova Pesquisa Científica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8zzfzn	<NULL>	Men or women between and including 18 and 65 years-old; women of childbearing age willing or able to use, at least, one highly effective contraceptive method throughout the study. In the context of this study, an effective method is defined as one that results in a low failure rate (i.e. less than 1% per year) when used consistently and correctly such as barrier methods, oral, injectables or implanted contraceptives, sexual abstinence or vasectomy of the partner; participants able to understand and perform all study procedures and instructions; participants who signed the Informed Consent Form (ICF) prior to any procedures regarding the study; participants diagnosed with moderate or severe nasal obstruction (i.e. at least number 5 of VAS - Visual Analogue Scale) due to cold or flu and who present symptoms within 24 to 48 hours after the onset of these symptoms.	Hypersensitivity to any of the components, including active ingredients, regarding the study medication; people that have used the study medication (Penetro) at previous time; total obstruction of one nostril by other etiologies that are not related to cold or flu, or for a period less than 24 hours and greater than 48 hours after the onset of symptoms; infectious processes of bacterial etiology (clinically diagnosed); participants on antibiotic treatment or being about to start an antibiotic therapy for another clinical condition; use of intranasal corticosteroid (7 days prior to the study) or systemic (15 days prior to the study), respecting the plasmatic half-life of the drug; use of intranasal or systemic decongestants or antihistamines in the 3 days prior to the study; participants taking inhaled or immunosuppressive drugs 7 days prior to the study; participants with nasal septum deviations (grades II and III), nasal polyps, pronounced hypertrophy of turbinates, hypertrophy of adenoids or other conditions determining nasal obstruction; use of a chronic oral respirator for 6 months or more before inclusion in the study; history of alcohol and/or drug abuse 3 months prior to the study, confirmed after a questioning done by the investigator; history of surgery in the 3 months prior to the study; being a smoker; female participants of childbearing age with a positive pregnancy test on the urine test; participation in a clinical study in the last 12 months; other diseases that, at the discretion of the principal investigator, may interfere with the results of the study; participants with known mental incapacity, language barriers or any incapacity that, at the discretion of the principal investigator, prevent the correct understanding of the Informed Consent Form (ICF) and study activities; known clinically significant systemic disease; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4ntszb	Hypertension and exercise: an intervention study in older patients	Not yet recruiting	Intervention	2019-04-02	<NULL>	<NULL>	2580	Effect of high-intensity interval training and moderate-intensity continuous training on ambulatory blood pressure, cardiac, vascular, autonomic, cerebral, psychological, metabolic and body composition outcomes in hypertensive older adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Rio Grande do Norte – UFRN	Hospital Universitário Onofre Lopes – HUOL	https://ensaiosclinicos.gov.br/rg/RBR-4ntszb	<NULL>	Both sexes; aged 60-80 years; previous diagnosis of hypertension; self-reported and clinically assessed physical activity readiness; unchanged pharmacological plan for hypertension in the last 4 weeks; willing to engage in any of the interventions; not engaging in a regular physical activity program in the past 3 months; insufficiently active (i.e., not performing 150 min/week of moderate physical activity and/or 75 min/week of vigorous physical activity, assessed through 7-day accelerometry)	Being unable or refusing to sign the consent form; previous cardiovascular events or diseases (e.g. unstable angina, severe arrhythmia, acute myocardial infarction, coronary artery disease, stroke, deep vein thrombosis, peripheral artery disease, uncontrolled arrhythmia, pacemaker use, etc.); limiting chronic pulmonary disease (emphysema, chronic bronchitis, asthma); chronic kidney disease in need of dialysis; incidence of cardiovascular or pulmonary events during the study; uncontrolled hypertension (&gt; 160/105 mmHg); diabetes with insulin use or decompensated (fasting glucose &gt; 300 mg/dl); high alcohol intake (&gt;14 doses per week); self-reported or perceived language, hearing or sight limitations that may come to hinder participation; exercise contraindication, as indicated on the maximum cardiopulmonary exercise test (e.g. EKG alterations suggesting myocardial ischemia); osteomioarticular issues that may prevent performing maximal cardiopulmonary exercise testing and moderate-to-vigorous aerobic exercise or osteomioarticular injury during the study (e.g. muscle injury resulting in limitations for exercise); neurological progressive disorders (Parkinson, multiple sclerosis, Alzheimer); cancer demanding treatment in the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-97qvzt	Oxygen muscles Evaluation and Exercise Capacity in children and adolescents with Cystic Fibrosis after a Home Physical Exercise Program	Recruiting	Intervention	2019-04-02	<NULL>	<NULL>	2581	Tissue Oxygenation Evaluation in peripheral muscles and Functional Capacity in children and adolescents with Cystic Fibrosis after a Home Physical Exercise Prescription Program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-14	Universidade Federal de Minas Gerais	Fundação Hospitalar do Estado de Minas Gerais -FHEMIG	https://ensaiosclinicos.gov.br/rg/RBR-97qvzt	<NULL>	Children and adolescents with cystic fibrosis; children and adolescents under treatment at the Outpatient Clinic of Complex Diseases of the  Hospital Infantil João Paulo II.	Patients with cystic fibrosis with acute exacerbation in the 15 days prior to the test; patients with cystic fibrosis with respiratory tract infections in the 15 days prior to the test; patients who give up participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-5qjg9t	Effects of brain stimulation in people with Anxiety Disorder	Recruitment completed	Intervention	2019-04-03	<NULL>	<NULL>	2582	Effects of Transcranial Direct Current Stimulation in persons suffered by Generalized Anxiety Disorders	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qjg9t	<NULL>	Be between 20 and 40 years old; clinical diagnosis according to the criteria of the American Psychiatric Association - DSM-V (2014), of TAG; not going through psychotherapy at the time of the study; ability to understand the purpose of the research and to answer the scales and questionnaires.	Be pregnant at the time of data collection; have a metallic, cerebral or pacemaker implant; history of epileptic disease, convulsive crisis and dependence on alcohol or narcotic substance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-7dmd7k	Development of a mobile application to apply questionnaires on diseases in the knees	Not yet recruiting	Intervention	2019-04-03	<NULL>	<NULL>	2583	Development and validation of knee questionnaires: an application for the evaluation of knee injuries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	https://ensaiosclinicos.gov.br/rg/RBR-7dmd7k	<NULL>	"Age over 65 years;
diagnosis of osteoarthritis of the knee using the criteria for osteoarthritis of the knee of the American College of Rheumatology (ACR, 1986) or to have grade II or III knee osteoarthritis of the Kelgren and Lawrence (KL) scale;
walking independently, without support device;
being for at least six months without practicing resisted physical exercise;
and do not present as follows:
any congenital, traumatic, infectious or deformity abnormality following injury to the knee joint that may have contributed to the development of secondary OA;
inflammatory arthritis (e.g., Rheumatoid Arthritis);
grade IV knee osteoarthritis on the KL scale;
knee flexion deformity greater than 15 degrees;
inability to walk or walk with the aid of devices;
neurological problems;
neuromuscular disease or injury;
surgery on the knee (s) in the last year;
corticosteroid injection in the last three months;
uncontrolled hypertension (&gt; 150/90 mmHg);
myocardial infarction in the last six months;
unstable cardiovascular disease;
conditions that may be exacerbated by the protocol (e.g., unstable angina);
fractures within the six-month period; present painful changes in the hips and / or ankles and / or pain in the lower back; or severe comorbidity that limits participation in the study.
Clinical guidelines established by the ACR include having knee pain on most days of the month and at least 3 of the following 6 criteria: age 50 and older, joint stiffness lasting 30 minutes, crepitation, bone sensitivity, bone augmentation, and heat palpable."	"Not participating in one of the sessions;
Any limitation that impedes the continuity of the participant in the study;
Participants with BMI&gt; 30 kg / m2 (minimize artifact at EMG)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-7t5bhh	Clinical efficacy of a distance exercise protocol associated with telephone professional follow-up for patients with chronic knee pain	Recruiting	Intervention	2019-04-03	<NULL>	<NULL>	2584	Clinical efficacy of a distance exercise protocol associated with telerehabilitation for patients with chronic knee pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-09	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7t5bhh	<NULL>	It will be included participants aged greater than or equal to 45 years, with chronic knee pain, defined by the International Association for the Study of Pain (IASP) as recurrent pain for at least 3 months, (score 4 on the Visual Analogue Pain Scale [EVA]) and medium to moderate physical dysfunction (score&gt; 20 of 68 on the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]).	Subjects who have undergone knee arthroplasty or other lower limb surgery will be excluded from the study, are already undergoing any treatment or exercise program, have any neurological or cardiovascular conditions that limit exercise and do not have access to a telephone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-9396d4	Strength Training Effects on Clinical Outcomes of Patients with Compensated Cirrhosis	Recruiting	Intervention	2019-04-04	<NULL>	<NULL>	2585	Strength Training Effects on Clinical Outcomes, Quality of Life and Functional and Neuromuscular Capacities of Patients with Compensated Cirrhosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Fundação Universidade de Caxias do Sul - FUCS/RS	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9396d4	<NULL>	Studied population will be of men and women with cirrhosis. To be a part of the sample, the patients will have to be in the inclusion criteria: age between 18 and 72 years, BMI 18.5-34.9, with no obesity or grade I (WHO). No force training prior to the study for 6 months, no current use of alcohol or tobacco for 6 months, if the patient is hypertensive it need to be controlled for inclusion, compensated cirrhosis Child A or B with histological documentation or through the association of laboratorial data ans image studies suggesting cirrhosis.	Exclusion criteria will be the following co-morbidities: decompensated diabetes, severe heart failure that prohibits exercise, periphereal amputations, chronic renal failure; clinical depression; muscular disease that physically impossibilits force training, decompensated cirrhosis, hence these patients cannot do heavy exercise. Regarding cirrhosis, exclusion criteria will be: decompensated cirrhosis, previous variceal bleeding without endoscopically confirmed erradication of esophageal varices, Child C, large varices, presence of ascitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4n3vwg	Effect of the electrical stimulation of the skin and heated thermal bag in normal labor	Data analysis completed	Intervention	2019-04-08	<NULL>	<NULL>	2586	Physiotherapy assistance in labor: the influence of transcutaneous electrical stimulation and the heated thermal bag during normal labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Hospital São João Batista	https://ensaiosclinicos.gov.br/rg/RBR-4n3vwg	<NULL>	Term, primiparous and multiparous women with ages ranging from 18 to 40 years, with 3 to 4 centimeters of uterine cervix dilatation, without analgesic and / or anesthetic drugs, with preservation of tactile sensitivity and cognition, were included in the study. medical authorization to perform the physiotherapy, without any complications, and who accepted to be part of the study after reading the ELCT	Pregnant women less than 18 years of age, with elective cesarean sections, with pacemakers, with some complications during labor, with morbidities such as diabetes, arterial hypertension or preeclampsia, with cognitive deficit, hypersensitivity to heat, reduced tactile sensitivity, without medical authorization to receive physical therapy and who did not agree to be part of the study after reading the ELCT	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-2c3brs	The use of the Laser in patients with Temporomandibular Dysfunction	Recruitment completed	Intervention	2019-04-08	<NULL>	<NULL>	2587	The use of Low Intensity Laser in Temporomandibular Dysfunctions: Randomized Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-02	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-2c3brs	<NULL>	"Patients with muscular or mixed TMD based on the Diagnostic Criteria for the investigation of temporomandibular disorders Axis I - Group 1 (DRC-TMD); Have not had TMD treatment for the last 6 months;
Fluency in the Portuguese language, to understand the RDC - TMD questionnaire."	Patients with therapy failures; Patients undergoing surgical procedures during the study period; Patients with complaints of side effects after the laser session.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-2z4fkw	Effect and acceptance of a substance that causes early-stage caries of permanent molars to stop developing compared to a treatment with fluoride varnish.	Recruiting	Intervention	2019-04-08	<NULL>	<NULL>	2588	Efficacy and acceptability in the use of cariostatic compared to fluoride varnish in caries lesions in enamel in first permanent molars.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2018-09-06	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2z4fkw	<NULL>	"Children who present at least one active initial carious lesion (Score 1 and 2 of ICDAS II + LAA);
Detected by visual and tactile examination on occlusal surfaces of first permanent molars at different stages of eruption, will be included in the study."	"Absence of first permanent molars; 
Permanent permanent molars, restored or with carious cavity in enamel or dentin;
Children with systemic impairment and / or special needs;
Children who have other dental treatment needs will be referred to try vacancies specializing in Pediatric Dentistry and the Pediatric Dentistry Clinic of UnB;
In addition, all individuals will receive oral hygiene guidelines and eating habits."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-6bcj43	Identification of cardiovascular risk factors in children	Data analysis completed	Observational	2019-04-09	<NULL>	<NULL>	2589	Characterization of cardiovascular risk factors and profile of cardiac autonomic modulation in school-age children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-20	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6bcj43	<NULL>	Children 6 to 10 years of age who do not use medicines that influence the autonomic activity of the heart and that do not carry previously diagnosed respiratory or metabolic diseases.	Children who present series of RR intervals with error greater than 5%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-9sm9dp	Cardiac frequency in persons with visual deficienty	Recruitment completed	Intervention	2019-04-10	<NULL>	<NULL>	2590	Variability of cardiac frequency in persons with visual deficienty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Faculdade de Medicina do abc de Santo André.	Faculdade de Medicina do abc de Santo André.	https://ensaiosclinicos.gov.br/rg/RBR-9sm9dp	<NULL>	"People of both sexes; over 18 years of age; with good visual acuity; healthy; and who do not need correctional lenses; such as glasses; will be eligible to form Group i. And people; also older than 18 years; both genders; but with visual impairment or blindness; in good general health; without other physical and mental disabilities; to constitute Group ii.
In this context; those who present visual acuity better than 20/30 in at least one eye will be admitted as participants of Group i; without visual impairment; and with visual impairment (Group II) those with visual acuity less than 20/70 and greater than 20/400 in the best eye; as blind people with visual acuity worse than 20/400; finger counts at 1 meter and even lack of light perception in the best eye according to criteria of the World Health Organization"	Those who do not meet the clinical criteria described or who refuse to participate or continue in the survey will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-9mcpjy	The use of ultrasound in the treatment of upper trapezius muscle nodules	Recruiting	Intervention	2019-04-10	<NULL>	<NULL>	2591	1 MHz and 3 MHz ultrasound in the treatment of the trigger points of upper trapezius muscle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-19	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-9mcpjy	<NULL>	Employees working in the University, aged between 20 and 40 years, of both sexes, with active trigger points in the superior trapezius muscle of the dominant side, with pains for at least 3 months, sedentary and using the computer daily.	Exclusion criteria consist of: participants who have undergone some surgical procedure in the last 3 months in the region of the neck and shoulders, who are taking some pain medication and participants who have a medical diagnosis of fibromyalgia, who present with a cognitive problem, pregnant, individuals with shoulder endoprostheses, tumors, acute post-trauma shoulder or cervical sequelae, thrombophlebitis, varicose veins and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8dyc7g	"Recruitment and flexibility of column muscles:
an evaluation of the effects of muscle release"	Data analysis completed	Intervention	2019-04-11	<NULL>	<NULL>	2592	Muscle recruitment and flexibility of spinal erectors: an evaluation of the effects from the Myofascial Release Technique	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-8dyc7g	<NULL>	students from the University; aged 18-35; both sexes	Participants who performed some physical activity in the 6 months prior to the survey; with diagnosis of any musculoskeletal lesions; significant postural deviations; pregnant or in the menstrual period; such as individuals who used generic anti inflammatory drugs during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4m3k2c	Effects of exercise in the treatment of depression, dementia and parkinson.	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	2593	Effectiveness of exercise in the treatment of major depression, Alzheimer&apos;s disease and Parkinson&apos;s disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4m3k2c	<NULL>	Seniors over 60 years. both sexes. diagnosed with major depression. Alzheimer&apos;s disease. Parkinson&apos;s disease.	Cerebrovascular infarction history. use of treatments such as electroconvulsive therapy. psychotherapy, illiterate and functional class III and IV according to the criteria of the New York Heart Association.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-62pd9w	Speech therapy rehabilitation in recovery of oral functions in patients with bone face trauma	Recruiting	Intervention	2019-04-12	<NULL>	<NULL>	2594	Speech therapy rehabilitation in recovery of stomatognathic functions in patients with face trauma	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-12	Universidade Federal do Rio Grande do Sul	Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-62pd9w	<NULL>	Over 18 years of age, able to voluntarily respond to the research protocol; Individuals with mandible fracture diagnosed by CT.	Individuals with neurological alterations that compromise oral motor functions or cognitive functions; With dentofacial anomalies; Submitted to orthognathic surgery, radiotherapy or chemotherapy for head and neck lesions previously; Have fractures of other bones of the face or skull; Internships in an Intensive Care Unit; Submitted to surgery before the first evaluation; With need of maxilomandibular fixation;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-5fn873	Assessment of the spinal anesthesia technique for benign surgery of the anus and rectum	Recruitment completed	Intervention	2019-04-12	<NULL>	<NULL>	2595	Effectiveness of modified sacral spinal anesthesia in ambulatory hemorrhoidectomies: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-28	Universidade Federal de Alagoas	Hospital Universitário Professor Alberto Antunes - HUPAA/UFAL	https://ensaiosclinicos.gov.br/rg/RBR-5fn873	<NULL>	Patients with grade III to IV hemorrhoids, anal fissure and anorectal fistula with an indication for surgical treatment that meet the following inclusion criteria: age greater than or equal to 18 years and less than or equal to 65 years of age, with I to III American Society of Anesthesiology - ASA.	Contraindication to spinal anesthesia and outpatient stay (absence of telephone contact, difficulty in transportation of locomotion, physical residence in another municipality of anesthetic-surgical intervention and outpatient admission with absence of prescribed postoperative medications), current anorectal inflammatory disease, cognitive disability to respond to the forms, any decompensated clinical pathology, neurological pathology, diabetes mellitus, urge urinary incontinence, previous prostate, renal or urologic surgery and drug allergy or any contraindication to the following drugs: propofol, midazolam, dipyrone, non-hormonal anti-inflammatory drugs, paracetamol, codeine, polyresulin and cinchocaine hydrochloride.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-2bsfm4	Effect of circuit exercises on muscular strength, balance and mood	Not yet recruiting	Intervention	2019-04-12	<NULL>	<NULL>	2596	Impact of a circuit exercise program on the physical-function capacity, on the risk of falls and depressive symptoms int he community-dwelling elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2bsfm4	<NULL>	Minimum age of 60 years; reside in the community; inactive; with a history of falls and/or risk of falling; not be participating in other research.	Bedridden or wheelchair-bound situation; motion dependent aid device; cognitive deficit; severe visual impairment; amputations or use of lower limb prosthesis; history of recent fracture of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-5745nv	Study of the use of caffeine in performance in cyclists.	Recruitment completed	Intervention	2019-04-12	<NULL>	<NULL>	2597	Effect of chronic and / or acute Caffeine in performance on the test time-trial on cyclists	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-28	Universidade Federal do Rio de Janeiro (UFRJ-Campus Macaé)	Universidade Federal do Rio de Janeiro (UFRJ-Campus Macaé)	https://ensaiosclinicos.gov.br/rg/RBR-5745nv	<NULL>	Minimum experience of two years in the modality and to have been classified among the 10 first places in the categories of the tests realized in the state of Rio de Janeiro. Training frequency of at least 3 x per week including sessions of technical and physical training. Do not be users of anabolic steroids. Athletes consuming caffeine amounts ?300 mg.day (Fit et al., 2013).	Hypertensive athletes and those who present nausea, gastritis and osteomioarticular lesions will be excluded during the experiment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3jhb3t	Use of a list of recorded words to analyze speech comprehension in children using cochlear implants	Data analysis completed	Observational	2019-04-15	<NULL>	<NULL>	2598	Use of the list of recorded words for evaluation of speech perception in children using cochlear implants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Hospital de Reabilitação de Anomalias Craniofaciais - HRAC/USP	Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-3jhb3t	<NULL>	Healthy children; both genders; age between five years to 10 years and 11 months; with typical hearing and language development	Children with hearing impairment and oral language disorders or other associated comorbidities were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3yc3bg	Proprioceptive Neuromuscular Facilitation Protocol for adults with Traumatic Upper Plexus Injury	Recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2599	Development of a protocol using Proprioceptive Neuromuscular Facilitation for treatment of patients with Traumatic Brachial Plexus Injury	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3yc3bg	<NULL>	Individuals who suffered traumatic upper brachial plexus injury; both sexes; age between 18 and 40 years; clinical diagnosis according to the routine protocol established at the service and confirmed by electrodiagnostic assessment - Electromyography (EMG) and/or Magnetic Resonance Imaging; who have indication of performing nerve transfer surgery; accompanied in the neurosurgery of peripheral nerves ambulatory at the Hospital da Restauração; with the minimum degree of comprehension necessary to understand the questions of the questionnaires, according to the Mini Mental State Examination (MMSE).	Patients with some type of articular ankylosis (shoulder, elbow, wrist); with incapacitating and uncontrolled neuropathic pain; who have suffered multi-trauma that makes it impossible to perform the positions and exercises of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-6gx9y3	Effect of aquatic exercises on the health of patients with rheumatoid arthritis	Data analysis completed	Intervention	2019-04-16	<NULL>	<NULL>	2600	Effect of hydrokinesitherapy on anxiety, depression and quality of life in patients with Rheumatoid Arthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade do Estado de Santa Catarina	Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPQ	https://ensaiosclinicos.gov.br/rg/RBR-6gx9y3	<NULL>	Female volunteers; Clinical diagnosis of rheumatoid arthritis; Present attestation that are suitable for the practice of aquatic activities; Age above 18 and with the disease in activity.	Lack of time to participate in the program, Physical incapacity to perform the physical exercise program, Heart disease or severe pulmonary disease; Resting systolic blood pressure above 180 mmHg, Dermatological problems, Urinary and / or fecal incontinence, Change medication or initiate another type of therapeutic intervention during the 12 weeks of the study and do not adapt to the aquatic environment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-4m5j4s	Non-Invasive Brain Stimulation Associated with Aerobic Exercise: Repercussions on Pain, Memory, and Sleep of Individuals with Chronic Migraine	Not yet recruiting	Intervention	2019-04-16	<NULL>	<NULL>	2601	Repetitive Transcranial Magnetic Stimulation associated with Aerobic Exercise: Repercussions on Perception of Pain, Memory and Sleep/Wake Rhythm of Individuals with Chronic Migraine	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-22	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4m5j4s	<NULL>	Individuals of both sexes between the ages of 18 and 65 who present a clinical diagnosis of chronic migraine.	Individuals with: History of seizure; Lesions in the region of the skull and/or cervical spine, as well as in the process of soft tissue healing; Presence of other neurological diseases or psychiatric disorders; Use of metal prostheses (excluding buccal cavity) or cardiac pacemaker; Pregnancy; Individuals contraindicated for the proposed aerobic exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-38s2x9	In-office bleaching sensitivity with a different application	Recruiting	Intervention	2019-04-16	<NULL>	<NULL>	2602	Sensitivity to in-office bleaching not applied in cervical area: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-38s2x9	<NULL>	Patients will be included in this clinical trial were men and women; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade A2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-345m6j	Nitric Oxide Generator device for the treatment of Pulmonary Hypertension	Data analysis completed	Observational	2019-04-17	<NULL>	<NULL>	2603	Nitric Oxide Generator for newborn Pulmonary Hypertension, a portable bedside device	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-09	Hospital de Clínicas	Consejo Nacional de Innovación, Ciencia y Tecnología (CONICYT)	https://ensaiosclinicos.gov.br/rg/RBR-345m6j	<NULL>	Written parental consent to receive the proposed therapy; newborns greater than 34 weeks of gestational age; diagnostic of severe refractory hypoxemia receiving conventional intensive care supporting treatment; no access to any other kind of inhaled Nitric Oxide therapy; oxygenation index over 10; pre and post-ductal difference in pulsioximetry equal or over 5	Neonates with multiple malformations or malformations incompatible with extra uterine life. Lack of parental consent to receive the proposed therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-4mvzz6	Effects of Physical Exercises with association of cognitive tasks on the mobility, muscle strength, cognition and quality of life of Individuals who suffered Cerebral Vascular Accident	Recruitment completed	Intervention	2018-05-21	<NULL>	<NULL>	2604	"Effects of Physical Exercises associated with increased complexity with Stimulation
in the mobility, muscular strength, cognition and quality of life of Individuals
Post-Stroke"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mvzz6	<NULL>	Post-stroke Volunteers; chronic phase of the disease; more than 6 months after Cerebral Vascular Accident, Territory of lesion in the Middle Cerebral Artery or in the Anterior Cerebral Artery, Cognition equal or superior to 21 points in the cognition score scale Montreal Cognitive Assessment (MoCA), 2 months of non-involvement in exercise programs physicist.	Cardiovascular complication that contraindicates the practice of physical exercises; involvement in other physical exercise programs, performing surgeries to attenuate clinical conditions resulting from stroke, chemical blockages to reduce spasticity, during the study that contraindicated its continuity in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-2vz89f	Study of microcirculation in Leprosy	Data analysis completed	Observational	2019-04-17	<NULL>	<NULL>	2605	Study of microcirculation in Leprosy using polarized orthogonal light (Microscan®)and laser-Doppler associated to iontophoresis: A model of dysautonomy by denervation	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-20	Universidade do Estado do Rio de Janeiro	Fundação Carlos Chagas Filho de Amparo À Pesquisa do Estado do Rio de Janeiro (FAPERJ)	https://ensaiosclinicos.gov.br/rg/RBR-2vz89f	<NULL>	"Male;
Be a tuberculoid leprosy patient under treatment;
Age between 20 and 60 years;
Present tuberculoid lesion in skin of superior and inferior limbs;
Do not have hypertension or Diabetes mellitus and other diseases that may alter microcirculatory parameters;
Do not be a smoker;
Do not present leprosy reaction state at the time of the examination;
Ability to follow the given guidelines and attend the evaluations;
Phototype I-IV of Fitzpatrick and
Sign the informed consent form."	"Obesity (BMI&gt; 35);

Spot present in another anatomical region other than superior and inferior limbs;

Single lesion of small-sized tuberculoid lesion with a recent biopsy scar occupying almost the entire lesion."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-7b2dyj	Muscular Strength and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-17	<NULL>	<NULL>	2606	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-30	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-7b2dyj	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-845hhf	Laser effect on Achilles Tendon Ruptures	Recruiting	Intervention	2017-07-21	<NULL>	<NULL>	2607	Photobiomodulation therapy associated with conservative treatment in Acute Achilles Tendon Rupture	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE	Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE	https://ensaiosclinicos.gov.br/rg/RBR-845hhf	<NULL>	Men aged between 18 to 65 years; unilateral achilles tendon rupture.	"Pacients whose treatment started after 10 days from lesion; bilateral lesion;
pacients with previous lesions in the achilles tendon."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-4wjx4q	Efficacy of educational intervention in precautions for the transmission of microorganisms in primary health care: a randomized clinical trial	Recruitment completed	Intervention	2017-11-09	<NULL>	<NULL>	2608	Educational intervention in precautions for the transmission of microorganisms in primary health care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4wjx4q	<NULL>	Nursing professionals in primary health care who are willing to participate.	Nursing professionals in primary health care who are enjoying vacations or some kind of leave at the time of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3wwwvd	The effect of acute exercise on cognitive performance in the elderly	Recruiting	Intervention	2018-06-02	<NULL>	<NULL>	2609	Effects of Physical Activity on brain function and cognition in the elderly with different levels of physical fitness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade Federal do Rio Grande do Norte - UFRN	Brain Institute Federal University of Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-3wwwvd	<NULL>	Men and women between 55 and 85 years old, with medical release and certificate of fitness to perform physical activity issued by cardiologist; attestation of the cardiologist already issued up to six months before the clinical evaluation will be accepted.	Obesity greater than grade 2 (body mass index up to 35); medication use that suppresses the responses of the neuroendocrine system; participants who do not achieve a minimum of 15 points in the mini mental state examinem; musculoskeletal limitations that limit the practice of physical activity or assessment;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-6z2dhd	Pilates in football	Recruitment completed	Intervention	2019-04-03	<NULL>	<NULL>	2610	Pilates in young soccer players	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-19	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6z2dhd	<NULL>	"The study will include athletes who:
Practice field and futsal football, male, sub 13 and sub 15 (age group between 13 and 15 years);
Participate in the sports training school of Uberaba Esporte Clube;
Those responsible agree to sign the free and informed consent form;
They have a training frequency higher than three times a week and maintain a weekly training load of at least nine hours."	"Athletes will be excluded from the study if:
Be suspended from training program;
Have muscle injury in the intervention period and / or evaluation for some game;
They underwent orthopedic surgery in the knee, ankle, hip during the evaluation period and / or intervention;
Do not attend the evaluations and / or interventions for two consecutive days;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-5mhjq5	Promoting preventive intentions in Leprosy with school adolescents	Not yet recruiting	Intervention	2019-03-07	<NULL>	<NULL>	2611	Cultural circles: promoting preventive intentions in Leprosy with school adolescents	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5mhjq5	<NULL>	"School adolescents, students of public schools in the city of Recife;
Age between 12 and 18 years;
To attend elementary school in the 7th year
Residing in the Political-administrative Regions: II, IV or VI;
Accept freely to participate in data collection through the questionnaire response"	Adolescents with special physical or mental condition, who present difficulties in understanding the questions of the instrument of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-8kf6ks	Influence of Hip and Thigh Muscle Strength in the Treatment of Patellar Dislocation.	Recruitment completed	Intervention	2018-01-31	<NULL>	<NULL>	2612	Influence of the Strengthening of the Lateral Rotators and Abductors of the Hip in the Treatment of Atraumatic Patellar Dislocation: A Randomized, Blinded Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-27	Universidade Federal de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8kf6ks	<NULL>	Inclusion criteria: individuals aged 16 years or older, of both genders, with a history of at least one episode of atraumatic, unilateral or bilateral patellar dislocation. Participants should present at the physical examination a signal of apprehension positive to the lateralization of the patella, pain upon palpation along the medial retinaculum, and increase of the patella inclination or abnormal excursion of the patella (J-sign) to flexion-extension of the knee.	Exclusion criteria: Individuals aged under 16 years and over 40 years, with loss of knee range of motion, with knee immobilized, in use of crutches or cane, with a history of traumatic patellar dislocation, with a history of meniscal injuries or anterior cruciate ligament, posterior cruciate ligament, medial collateral and lateral collateral ligaments injuries. Individuals who have undergone any surgical intervention on the hips, knees, and ankles of any lower limbs will also not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-48342g	Comparison of catheters placed in the vein regarding the formation of blood clots	Recruiting	Intervention	2019-04-18	<NULL>	<NULL>	2613	Peripheral insertion central catheter with Bioflo® technology versus Power Picc®: incidence and predictors of thrombosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital Israelita Albert Einstein	Faculdade Israelita de Ciências da Saúde Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-48342g	<NULL>	Hospitalized patients with intravenous therapy scheduled for 6 days or longer with a medical order for PICC insertion	"Patients classified as urgency, because it prevented randomization;
Patients who required a specific catheter for continuity of treatment;
Patients who required a new PICC after being recruited for the study;
Patients with a previous diagnosis of DVT;
Patients previosuly mastectomized on the side chosen for insertion of the catheter;
Patients with damaged/sclerosed peripheral venous network;
Patients with bacteremia;
Patients with dermatitis/cellulitis or trauma to the arm to be punctured."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-2gh23p	Effects CrossFit training and cranberry supplementation on the immune system	Recruitment completed	Intervention	2019-04-18	<NULL>	<NULL>	2614	Effects of extreme conditioning program and supplementation of cranberry on immunomodulation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2gh23p	<NULL>	Do not have any musculoskeletal, autoimmune, cardiac, pulmonary or hypersensitivity disorders; do not use medications or food supplements including substances with antioxidant function for at least 30 days and antibiotic at least six months prior to the study period; be enrolled in CrossFit Quest and regularly practice for at least three months.	Do not perform any of the blood collections; do not perform any of the physical performance assessments; present any injury or motor impairment to perform the training; any upper respiratory tract infection during the experiment; regularly consume any food supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the cranberry or placebo doses; have known allergy or intolerance to cranberry products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-9d8ryw	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with neck pain	Not yet recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2615	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with chronic non-specific neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Centro Universitário União das Américas - UNIAMÉRICA	Centro Universitário União das Américas - UNIAMÉRICA	https://ensaiosclinicos.gov.br/rg/RBR-9d8ryw	<NULL>	Aged between 18and 65 years; body mass index (BMI) &lt;30 kg / m², with neck pain for a period equal or greater than 3 months; a Portuguese-Brazilian version of the Neck Disability Index (NDI) score of 5 or higher and a Numeric Rating Scale (NRS) score of 3 or higher at rest or during active neck movement. The participant must be willing to participate in the study and sign the Informed Consent Term.	Participants are excluded if they had: bone diseases; bone fracture; history of tumor or cancer; cervical whiplash injury; history of neck trauma; previous spine surgery; have undergone physiotherapeutic or medical treatment for neck pain in the last 3 months prior to the study; using analgesic, anti-inflammatory and muscle relaxant medications during the week prior to the study; use of medications that could alter cardiac autonomic activity, such as (propranolol and atropine); systemic diseases; diagnosed fibromyalgia; diagnosed cardiovascular disease; orofacial pain; pregnancy; cervical radiculopathy; smoking; ethyl alcohol; diagnosed respiratory disease; diagnosed neuromuscular disease; and inability to perform the tests and answer the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-2ph4f9	Impact of dietary fiber supplementation on blood pressure inflammation in nutritional status and methylation of the aducin gene in adult women	Recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2616	Effect of dietary fiber supplementation on blood pressure and pcr values ??in adult women with methylation of the add1 gene	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2ph4f9	<NULL>	Voluntary women presenting with arterial hypertension or women without arterial hypertension aged between 20 and 60 years who do not present with serious cardiac diseases, renal, hepatic or serious psychiatric deficiencies.	Women under the age of 20 and over 60 years; who have severe cardiac, renal, liver and serious psychiatric illness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-84s2yw	A phase III double-blinded, placebo controlled study of Pracinostat in association with Azacitidin for improving survival in patients facing Acute Myeloid Leukemia	Recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2617	A phase III, double-blind, placebo-controlled, multicenter, randomized study of Pracinostat in combination with Azacitidine in patients older or equal to 18 years with newly diagnosed Acute Myeloid Leukemia unfit for standard induction chemotherapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-10-22	Helsinn Healthcare SA	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-84s2yw	<NULL>	Male or female patients equal or older than 18 years of age with newly diagnosed, histologically confirmed, AML including de novo, secondary to antecedent hematologic disorders, or treatment-related disease with intermediate or unfavorable-risk cytogenetics; patients unable to receive intensive chemotherapy regimens at enrollment, based on one of the following: a. age equal older than 75 years, or b. age less than 75 years with at least 1 of the following co-morbidities: b1. an ECOG performance status of 2, b2. clinically significant cardiovascular disease defined as: left ventricular ejection fraction (LVEF) equal or less than 50% measured within 3 months prior to Day 1, confirmed by ECHO/MUGA, congestive heart failure requiring medical therapy, chronic stable angina requiring medical therapy, prior cerebrovascular accident with sequelea, b3. clinically significant pulmonary disease defined as: forced expiratory volume in 1 second (FEV1) equal or less than 65% of expected, lung diffusing capacity for carbon monoxide (DLCO) equal or less than 65% of expected confirmed by pulmonary tests, b4. diabetes mellitus with symptomatic end-organ damage (e.g., retinopathy, nephropathy, neuropathy, vasculopathy), b5. autoimmune inflammatory conditions (e.g., rheumatoid arthritis, systemic lupus erythematous, inflammatory bowel disease, or similar) requiring chronic disease modifying therapy (e.g., etanercept, adalimumab, infliximab, rituximab, methotrexate, or similar), b6. class III obesity defined as a Body Mass Index (BMI) more than 40 kg/m2, b7. renal impairment defined as serum creatinine greater than 1.3 mg/dL (greater than 115 ?mol/L) or creatinine clearance less than 70 mL/min, b8. clinically significant cognitive impairment defined as requiring medical therapy and/or assistance with activities of daily living; presence of at least 20% blasts in bone marrow; peripheral white blood cell (WBC) count less than 30,000/?L, for cyto-reduction, hydroxyurea is allowed during screening and up to Cycle 1, Days 1-14, to reduce WBC count to less than 30,000 ?L prior to Day 1. After Cycle 1, Day 14, hydroxyurea is prohibited; ECOG performance status less or equal to 2; adequate organ function as evidenced by the following laboratory findings: total bilirubin less than 2 × upper limit of normal (ULN) or less than 3 × ULN for patients with Gilbert-Meulengracht Syndrome, Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less or equal to 2.5 × ULN; serum creatinine less or equal to 1.5 × ULN or creatinine clearance equal or greater than 50 mL/min according to institutional standards; QT-interval corrected according to Fridericia’s formula (QTcF) equal or less than 450 ms on electrocardiogram (ECG) at screening; male patient who is surgically sterile, or male patient who is willing to agree to remain completely abstinent (refrain from heterosexual intercourse) or who use barrier contraceptive measures and agree to refrain from donating sperm during the entire study treatment period; female patient who is of childbearing potential willing to use adequate contraceptive measures while participating on study, or willing to completely abstain from heterosexual intercourse during the entire study treatment period; female patient who is of childbearing potential must have a negative serum pregnancy test result within 3 weeks prior to starting study drugs; willing to provide voluntary written informed consent before performance of any study related procedure not part of normal medical care; willing and able to understand the nature of this study and to comply with the study and follow-up procedures.	Able to receive intensive induction chemotherapy; AML-associated inv(16)/t(16;16)/del(16q), t(15;17) (i.e. promyelocytic leukemia) with/without secondary aberrations; t(8;21) lacking del (9q) or complex karyotypes; resence of an active malignant disease within the last 12 months, with the exception of adequately treated cervical cancer in-situ, non-melanoma skin cancer and superficial bladder tumors (Ta [non-invasive tumor], Tis [carcinoma in situ] and T1 [tumor invades lamina propria]). Other malignancies may be considered after consultation with the Medical Monitor; life-threatening illnesses other than AML, uncontrolled medical conditions or organ system dysfunction that, in the Investigator’s opinion, could compromise the patient’s safety or put the study outcomes at risk; uncontrolled arrhythmias; any Class 3-4 cardiac diseases as defined by the New York Heart Association (NYHA) functional classification; evidence of central nervous system (CNS) involvement; previous chemotherapy for AML except for the following, which are allowed: hydroxyurea for cytoreduction, one course of hypomethylating agent therapy (i.e.; up to 7 doses of azacitidine or 3-5 days of decitabine) within 30 days prior to enrollment (Day1); use of experimental drugs within 30 days prior to screening; received prior HDAC inhibitor therapy; received prior treatment with a hypomethylating agent, except as allowed in Exclusion Criterion 7.b; known hypersensitivity to any components of pracinostat, AZA, or mannitol; history of human immunodeficiency virus (HIV) or an active and uncontrolled infection with hepatitis C virus (HCV) or hepatitis B virus (HBV); gastrointestinal (GI) tract disease that causes an inability to take oral medication, malabsorption syndrome, or a requirement for IV alimentation; prior surgical procedures affecting absorption; or uncontrolled inflammatory GI disease (e.g., Crohn’s disease, ulcerative colitis); any disease(s), psychiatric condition, metabolic dysfunction, or findings from a physical examination or clinical laboratory test result that would cause reasonable suspicion of a disease or condition, that contraindicates the use of pracinostat and/or AZA, that may increase the risk associated with study participation, that may affect the interpretation of the results, or that would make the patient inappropriate for this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3pgyyq	prospective randomized study in the use of pregabalin for control and prevention of chronic pain after inguinal hernioplasty	Not yet recruiting	Observational	2019-04-22	<NULL>	<NULL>	2618	prospective randomized study in the use of pregabalin for control and prevention of chronic pain after inguinal hernioplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	universidade de santo amaro	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-3pgyyq	<NULL>	Male patients, aged between 18 and 60 years, with primary unilateral inguinal hernia, without comorbidities	Patients on non-hormonal anti-inflammatory or corticosteroid use prior to surgery, discontinuation of medication use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-65b8f4	The effect of whey protein and acid ascorbic supplementation on nutritional status, inflammation, oxidative stress and quality of life: a study in patients with chronic renal disease on hemodialysis	Recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2619	The effect of whey protein and ascorbic acid supplementation on nutritional status, inflammation, oxidative stress and quality of life: randomized clinical trial in hemodialysis patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-65b8f4	<NULL>	Be 19 years of age or over; have a diagnosis of CKD; perform HD three times a week in a period of three months and sign the Informed Consent Form	Make use of antioxidants like Vitamin C or E; amino acids; protein or ketoacid supplements, or immunosuppressive drugs within 2 months prior to enrollment or who had an infection or hospitalization in the month prior to the start of the study. Being a carrier of the acquired immunodeficiency virus (HIV); to present a diagnosis of cancer; advanced heart failure, chronic lung disease; liver disease; metal parts in the body like cardiac stimulators, stents, metal dots; have atrophied or amputated limbs; to be hospitalized; being pregnant or breastfeeding; have sequelae that prevent the measurement of parameters and have no ability to understand or communicate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3wsdhs	Effects of pilates and aerobic exercise in women undergoing treatment for breast cancer	Recruitment completed	Intervention	2018-01-25	<NULL>	<NULL>	2620	Effects of pilates and aerobic exercise in women undergoing treatment for mammary neoplasia: a control randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-17	Hospital Universitário de Brasília	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-3wsdhs	<NULL>	Women who underwent surgical treatment for breast câncer; as well as axillary lymph node dissection; radiotherapy; chemotherapy and who complain of pain and fatigue.	Women with active câncer; lymphedema; limitation to physical exercise or with limitation to answer some questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-6qx7m5	The role of technology in obeying different types of treatment of insulin-dependent diabetes mellitus	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2621	The role of technology in self-management and adherence to different treatment regimens for insulin-dependent diabetes mellitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-28	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Associação dos Diabéticos de Ourinhos (ADO)	https://ensaiosclinicos.gov.br/rg/RBR-6qx7m5	<NULL>	Patients under following at ADO with type 1 DM or LADA. Any age. Any A1C.  Use of insulin analogues (ultra-slow - Detemir, Glargina 100, Glargina 300, Degludeca - and ultrafast - Glulisine, Aspart or Lispro). In the subgroup of patients under carbohydrate counts, those who have had this modality of treatment for at least 3 (three) months. In the subgroup of patients undergoing treatment with CSII, those who have had this treatment modality for at least 3 (three) months.	Patients with other types of DM than those previously mentioned. Patients who use insulin, but not in MDI scheme. Patients treated with conventional insulin (NPH - Neutral Protamine Hagedorn - and regular), although in an MDI scheme.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-3w744z	Compassion Meditation vs. Social Vulnerability: Effects on Individual and Collective Well-Being	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2622	Cognitively-Based Compassion Training - CBCT  vs. Social Vulnerability: Effects on Individual and Collective Well-Being	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-17	Universidade Federal de São Paulo	Escola Paulista de Enfermagem UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-3w744z	<NULL>	Healthy volunteers; both sexes; aged between 18 and 75 years; the region for at least a year; participating in some action linked to the Center of Excellence in Early Childhood for at least 3 months	Subjects diagnosed with some mental illness and in treatment of mental illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-2k6jzs	The evaluation of practices to the binomial mother in the delivery room before and after the Neonatal Resuscitation Course	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2623	The effectiveness of the Neonatal Resuscitation Course in assisting the newborn in the delivery room	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2k6jzs	<NULL>	neonates with gestational age greater than or equal to 34 weeks, incluing twins; absence of severe congenital malformation that may lead .	Mothers with positive serology for imunodeficiency virus (HIV); human limphotrophic T virus( HTLV).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-4bdbpk	Diagnostic and treatment of skin cancer lesions using Photodynamic Therapy - a less invasive technique than surgery with the application of a medication that interacts with light	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2624	Diagnostic and treatment of skin cancer using Photodynamic Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-24	Hospital Amaral Carvalho	Instituto de Física de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4bdbpk	<NULL>	patients of both sexes; older than 18 years;  present malignant lesions of the basal cell carcinoma nodular subtype (according to the International Classification of Diseases ICD 10, code D04.9) with a maximum diameter of two (2) centimeters (initial lesions); patients with multiple lesions may also be treated, provided that each lesion fits the characteristics described in the previous item; patients with impaired neurological or judgmental capacity may be included as long as the responsible relative for their care signs the consent term.	patients allergic to any of the excipients present in the formula; infiltrative basal cell carcinoma  subtype histological micro-infiltrative, sclerodermiform, and flat-cicatricial, terebrante, as well as squamous cell carcinoma or epidermoid carcinoma and melanoma; patients with porphyria; nodular lesions  of basal cell carcinoma with more than 2 cm in diameter; patients under 18 years of age; pregnant and lactating women; women of childbearing age; patients with photosensitive diseases, for example, lupus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-5chrq5	Effect of a single session of physical exercise on blood markers in adult individuals with incomplete spinal cord injury	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2625	Effect of a single session of gait training with body weight support on epigenetic parameters, brain derived neurotrophic factor levels and injury markers and peripheral blood muscle repair in adult individuals with incomplete spinal cord injury	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-16	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-5chrq5	<NULL>	For both groups, individuals with incomplete traumatic LM; aged between seventeen and fifty-five years old; of both genders and diagnosed for at least 6 months and at most 5 years of injury, will be included. For the trained groups, the subjects should be submitted to an intervention program (neurofunctional rehabilitation) for at least 6 months. For untrained groups, individuals should be performing only conventional physiotherapy.	As exclusion criteria, for both groups, all those with contraindications to weight support, such as individuals with hip fracture or lower limb or who present scabs, are included. Also, patients who present with unstable angina or other decompensated heart disease; chronic obstructive pulmonary disease; neurological diseases such as Parkinson&apos;s; stroke; who exhibit symptomatic drop in blood pressure when upright; who use medications with HDAC inhibitors valproic acid) and are undergoing active inflammation / infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-8949x2	Methods of pain relief during the Eye Examination and their neurobehavioral effects in prematuros: randomized clinical test	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2626	Neurobehavioral and physiological responses of pain in preterm infants: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-24	Faculdade de Ceilândia da Universidade de Brasília	Hospital Materno Infantil de Brasília (HMIB)	https://ensaiosclinicos.gov.br/rg/RBR-8949x2	<NULL>	Preterm newborns, born with up to 32 weeks of gestational age and 1500g of weight; of both genders; with first eye examination scheduled after 30 days of life; which show hemodynamic stability, with parameters of heart rate and oxygen saturation within the normal range, up to 120 beats per minute or above 95% oxygen saturation respectively.	Premature infants who are in assisted ventilation will be excluded from the study; have grade III or IV intraventricular hemorrhage or subsequent leukomalacia; congenital nervous system disease, neurological and renal malformation or impairment, or use of opioids and corticosteroids among other drugs that interfere with nociceptive responses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-5np2gs	Increased carbohydrate intake to improve performance of MMA fighters	Recruitment completed	Intervention	2019-04-22	<NULL>	<NULL>	2627	Effect of a Feeding Program for Strength Training on MMA	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5np2gs	<NULL>	"Healthy volunteers; males; adults; non-smokers; 
age between 18 and 35 years."	voluntary smokers; sufferers of some form of serious illness; history of alcohol or drug abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-6s3kkr	Blood pressure control with metoprolol or clonidine medications in ear, nose or throat surgeries in patients with high blood pressure	Recruiting	Intervention	2019-04-24	<NULL>	<NULL>	2628	Blood pressure control with metoprolol or clonidin in otorhinolaryngology surgery for poorly controlled hypertension patient	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-10	Hospital das Clínicas	Hospital das Clínicas	https://ensaiosclinicos.gov.br/rg/RBR-6s3kkr	<NULL>	Patients older than 18 years and up to 65 years old, hypertensive, who arrive at the surgical center to perform otorhinolaryngological surgeries	Patients with a heart rate of less than 60 beats per minute, patients with contraindication or allergy to clonidine or metoprolol, patients weighing less than 50 kg or patients weighing more than 100 kg, patients using a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-42whhj	Stair climb task training after stroke: a feasibility study	Not yet recruiting	Intervention	2019-04-24	<NULL>	<NULL>	2629	Elliptical training on improvement of stair ascent capacity of individuals with hemiparesis in the chronic phase: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-22	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-42whhj	<NULL>	As criteria for inclusion are indicated: individuals who had the BIRD for more than 18 months; residents in the community; able to provide consent, criterion set to showing the final score on the Mini Mental State examination of 13 to 18 for illiterates, low/middle education, and 26 for high Education; are over 20 years old; are able to climb ladder with or without help of auxiliary devices of March for at least 4 steps with comfortable speed. Score between 4 and 6 in MIF rating scale (M-Locomotion: Stairs); submit a medical certificate to be able to physical activity	As exclusion criteria: some unstable heart condition that can restrict your participation in a moderate exercise program (i.e. not considered suitable by the physician in charge); cognitive deficits and/or of language (aphasia of comprehension) severe when asked to answer commands simple engines, which can restrict your answer to follow instructions during the data collection and/or intervention; other relevant medical conditions that may affect your ability to walk, as vestibular disorders, severe osteoarthritis or other neurological conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-6bqp2p	Frontal brain Transcranial Magnetic Stimulation for Craving reduction in Smokers	Recruiting	Intervention	2019-04-24	<NULL>	<NULL>	2630	Dorsomedial prefrontal inhibitory Transcranial Magnetic Stimulation for Craving reduction in Smokers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Singular Psiquiatria e Neuromodulação	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6bqp2p	<NULL>	Severe nicotine use disorder as per the Fagerström Test for Nicotine Dependence (score &gt;6); at least mild craving scores in the Questionnaire of Smoking Urges-Brief (&gt;27); not presently seeking treatment for smoking; at least 18 years old; right handed, completed high school.	Severe substance use disorder as screened by the ASSIST tool; diagnosis or high risk of diagnosis of psychiatric disorder according to screening tools and clinical interview; presently taking bupropione, nortriptiline or varenicline; history of brain lesions; history of epilepsy, neurosurgical procedures or cardiac pace maker; pregnant women or high risk of pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-9v3q33	Loss urinary treatment with heat waves and pelvic floor exercises.	Not yet recruiting	Intervention	2019-04-25	<NULL>	<NULL>	2631	Fractional Microablative Radiofrequency and Pelvic Floor Muscle Trainng in the treatment of women with Stress Urinary Incontinence: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Cienciena Médicas da Universidade Estadual de Campinas (UNICAMP)	Faculdade de Cienciena Médicas da Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-9v3q33	<NULL>	Women between 45 and 65 years of age with symptoms of stress urinary incontinence and mixed urinary incontinence with predominance of the stress component identified through anamnesis and with availability to attend the therapies at the date and places scheduled for the proposed treatment.	Use of pacemaker; presence of genital prolapses stages III and IV; decompensated heart disease; cognitive deficit; peripheral or central neurological disorders; presence of any type of cancer; presence of cervical dysplasia; history of active urinary tract or vaginal tract infection; decompensated metabolic diseases; physiotherapeutic treatment with previous pelvic floor training in the last 12 months; use of estrogen via the vagina in the last 6 months; current use or in the last 6 months of oral hormone replacement therapy; patient already undergoing prolapse correction or sliding surgeries. presence of intrauterine device; MAP shrinkage force equal to zero according to the Oxford Modified Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-7t4zxq	Clinical Performance of Total Ceramic / porcelain Crowns on Posterior Teeth	Recruiting	Intervention	2019-04-25	<NULL>	<NULL>	2632	Evaluation of the Clinical Performance of Posterior Total Crowns of Monolithic Ceramics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-14	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7t4zxq	<NULL>	"Patients with good oral and systemic health;
Absence of parafunctional habit or controlled parafunctional habit;
 Proper oral hygiene;
Teeth in need of posterior unitary prosthesis, in which the dental remnant is vital or with satisfactory endodontic treatment;
 The remnant should have periodontal health and absence of periapical changes that may compromise the longevity of the treatment."	"Presence of severe periodontal disease;
Presence of removable prostheses in the 
antagonistic arch of the tooth to be treated or in the same arch;
Patients without occlusal stability or without posterior containment;
Edentulous spaces adjacent to the tooth to be restored;
Malocclusions"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-27gtnr	Physical therapy after breast cancer surgery and reconstruction	Recruitment completed	Intervention	2018-03-07	<NULL>	<NULL>	2633	Randomized clinical trial with two physical therapy protocols after breast cancer surgery and immediate reconstruction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-23	Universidade Federal de São Paulo - UNIFESP/EPM	Samantha Karlla Lopes de Almeida Rizzi	https://ensaiosclinicos.gov.br/rg/RBR-27gtnr	<NULL>	Women; older than 18 years; with breast cancer, who will be submitted to breast  surgery (radical or conservative), followed by  immediate reconstruction alloplastic (tissue expander or breast implant) or oncoplastic (breast reduction or contralateral symmetrization).	patients that will be submited to bilateral oncology surgery; patients that will be submited to reconstruction with autologous tissue or breast surgery without reconstruction; patients with motor or neurological deficits prior to surgery; patients with cognitive impairment; patients that do not accept to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-6txv3v	Application of Multidisciplinary Therapy with Electronic Means for the Obese Treatment in Adolescents.	Recruiting	Intervention	2019-04-26	<NULL>	<NULL>	2634	Application of Blended Multidisciplinary Therapy Methodology with Electronic Means for the Obese Treatment in Adolescents.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6txv3v	<NULL>	Volunteers with 14 to 19 years old; Body mass index above the 95th percentile of the curve proposed by the World Health Organization; post-pubertal Tanner Stage above five.	Genetic disease; pregnancy; previous drug utilization; chronic alcohol consumption; presence of viral hepatic diseases; other causes of liver steatosis; inability to perform physical activities; have no access to any electronic means.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-2wznfh	Goal-oriented or diet-based nutrition counseling for children who are overweight	Recruitment completed	Intervention	2019-04-26	<NULL>	<NULL>	2635	Nutritional counseling with cognitive behavioral intervention as a strategy for behavioral food change for children with overweight	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2wznfh	<NULL>	Children 5 to 10 years old with obesity according to BMI / I according to WHO and SISVAN parameters. In addition, the possibility of attending biweekly meetings for the period necessary for the development of activities together with parents and / or guardian residing in the same house.	The exclusion criteria will be children with mental and / or psychological illness that interferes with comprehension and those who are undergoing dietary / nutritional monitoring during the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-56pbrx	The relationship between balance and loss of function in people with recurrent ankle torsion	Recruiting	Observational	2019-04-26	<NULL>	<NULL>	2636	Association between postural balance and functional limitation in individuals with chronic ankle instability	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-56pbrx	<NULL>	"According to the International Ankle Consortium (GRIBBLE et al., 2013b):
Group control:
No history of ankle sprain;
Sign the free informed consent form (TCLE).

ICT Group:
History of ankle sprain, the first being for at least 12 months with inflammatory signs, in addition to interrupting physical activity for at least one day and the last episode for at least 3 months;
Feeling of falsehood without resulting in sprain and / or recurrent sprain (two episodes in the last 6 months) and / or sensation of instability confirmed by validated questionnaires (IdFAI score ?11; CAIT score ?24; 5 questions, including question one);
Sign the free informed consent form (TCLE)."	"The exclusion criteria of the study will be according to the International Ankle Consortium (GRIBBLE et al., 2013b) and will be the same for both groups:
History of lower limb surgery;
History of fractures in the lower limbs that required realignment;
Have suffered acute musculoskeletal injury to lower limbs resulting in withdrawal of physical activity for at least one day in the last 3 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-86c6jp	Evaluation of the effect of the school&apos;s prevention program Elos to aggressiveness	Not yet recruiting	Intervention	2019-04-26	<NULL>	<NULL>	2637	Evaluation of the effectiveness of the program Elos-Building Collectives to reduce aggression in children from 1st to 4th year of elementary school	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	Universidade Federal de São Paulo	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-86c6jp	<NULL>	Be a student enrolled in the 1st to 4th. year of public schools selected randomly from the INEP list, and consent to answer the questionnaire of pre and post test.	Questionnaires without adequate codes; Refusal in completing the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-5tj3jm	Evaluation of the effect of 6% hydrogen peroxide activated with violet LED light on color change and tooth sensitivity after in-office bleaching	Recruitment completed	Intervention	2019-04-26	<NULL>	<NULL>	2638	Effectiveness of in-office bleaching using hydrogen peroxide 6% with photoactivation LED Violet: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5tj3jm	<NULL>	Patients included in this clinical study should be men and women; with good general and oral health; have six upper and lower anterior teeth without carious lesions or restorations; the upper right incisor should be in color C2 or darker according to the value-oriented Vita Classical color scale (Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-79c83z	Change of lifestyle in women with breast cancer	Recruitment completed	Intervention	2019-04-26	<NULL>	<NULL>	2639	Evaluation of change lifestyle in women with Breast Cancer, through Quality of Life, Depression, Function, Nutrition appraisal and evaluation Biological Mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-15	Universidade Federal de Minas Gerais	Instituto de Previdência dos Servidores do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-79c83z	<NULL>	patients with breast cancer until one year after diagnostic in ambulatory treatment and all the treatment can practice exercise and answer the questionnaire	patient can´t practie exercise and can´t answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7h6wfr	Microscopic analysis of cleaning of dental channels with automated instruments	Recruitment completed	Intervention	2019-04-26	<NULL>	<NULL>	2640	Apical root canal cleaning comparison after preparation with reciprocating and rotary instruments - randomised trial in vivo analysis	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-7h6wfr	<NULL>	20 patients between 18 and 40 years; regardless of race and gender; with vital inferior molars indicated for exodontia by periodontal problems or without restorative possibility.	Sistemic problems; pulp necrosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-5jszxw	Analysis of the effective dose for analgesia in knee surgery with saphenous nerve block by ultrasound	Recruiting	Intervention	2019-04-30	<NULL>	<NULL>	2641	Evaluation of the Minimum Effective Concentration (CEM) analgesic of ropivacaine in ultrasound guided safeno block for knee arthroscopy Randomized, double blind study	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5jszxw	<NULL>	Knee meniscopathy; meniscectomy surgery	Patient refusal; coagulopathy; pregnancy; local infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-5km45m	&quot;Teaching of foot care&quot; in people with Diabetes Mellitus type 2: a randomized clinical trial	Recruitment completed	Intervention	2019-04-30	<NULL>	<NULL>	2642	&quot;Teaching of foot care&quot; in reducing the risk of integrity of harmful skin of people with Diabetes Mellitus type 2: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de Alfenas	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5km45m	<NULL>	Target sample size is 168 people with Type 2 Diabetes Mellitus; diagnosed for at least five years; registered in the Health Information System for Primary Care (SIAB); with a minimum age of eighteen years and maximum age not stipulated and of both genders.	Persons with T2DM who present active ulcers or lower limb amputations; deficits in cognitive ability, identified by the Mental State Mini-Exam (MMSE), and those who do not want or can not participate in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6fntmd	AAssessment of the potential for improvement in hearing health. Consumer satisfaction with sound amplification with a new high-performance hearing aid-WHO-Inc compared to existing Digital.	Recruitment completed	Intervention	2019-04-30	<NULL>	<NULL>	2643	Assessment of the potential of hearing improvement by performing a double-blind, randomized, cross-over study in the state of São Paulo. Consumer satisfaction with sound amplification in everyday life with a new high-performance hearing aid - WHO Inc. compared to advanced digital hearing aids available on the market	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6fntmd	<NULL>	"Sensorineural hearing loss with tonal thresholds of 25-85 dB NA per octave frequency between 250 and 4000 Hz, in 4 frequencies up to the threshold of 30-70 dB NA;
Not Protected with AASI in the last year;
Being in good health (self report);
Present normal vision or corrected vision for normal vision (less than or equal to 20 / 50)
Age between 21 and 75 years;
Maintain ability to speak, read and write;
No evidence of significant accumulation of wax or a foreign body in your external ear canal;"	"Presence of acute or chronic limiting diseases;
Presence of unilateral or worsening hearing loss in the last 90 days;
Blockage of the external ear canal or Ear infection or clogged ear sensation;
Otorrhea in the last 90 days;
Presence of sudden hearing loss in the last 90 days;
Dizziness or vertigo at the time of selection;
Presence of any congenital or traumatic deformity of the ear;
Presence of pain or discomfort in the ear;
Presence of conductive hearing loss or asymmetric hearing loss;
Presence of hearing loss that exceeds the limits that can be successfully aided by hearing loss (hearing loss);
Presence of air bone GAP greater than or equal to 15 decibels at 500 Hz, 1,000 Hz and 2000 Hz.
History of otological diseases or neurological disorders;
Individuals who do not speak Portuguese;
Any clinically unstable medical condition;
Any condition which, in the investigator&apos;s opinion, places the participant at unacceptable risk if participating in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4jg93f	The influence of physiotherapy on labor in low-risk pregnant women	Recruiting	Intervention	2019-04-30	<NULL>	<NULL>	2644	The Influence of Physiotherapy in labor in low risk parturients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Centro Universitário São Camilo	Hospital Ipiranga	https://ensaiosclinicos.gov.br/rg/RBR-4jg93f	<NULL>	Only those parturients who agree to participate in the study and with the disclosure of the data for academic purposes and with the consent, to be signed in the Informed Consent Term (TCLE - Appendix 1) will be included in the study. The study will include adolescents and women between 13 and 43 years of age, primiparous of normal full term delivery, with gestation from 37 to 42 weeks admitted to labor at Ipiranga Hospital with dilation of up to 7cm; not submitted to previous abdominal or urogenital surgery; not having diseases or physical conditions that could interfere with childbirth (pelvic or spinal injury, diabetes, pelvic organ prolapse, neurological diseases); not have difficulty in communication due to decreased hearing acuity or speech limitation.	Multiparous women will not be included; parturients with preterm birth or delivery with pelvic presentation, who progress to cesarean by maternal and / or fetal indication, who have metabolic diseases, pregnancy-specific hypertension (DHEG), oncology patients and with twin pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-9k2s42	Effects of protein supplementation and strength exercise on nutritional, metabolic and associated factors in bariatric patients with a further 24 months postoperative	Recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2645	Effects of protein supplementation and resistance training on nutritional, metabolic and associated factors in late postoperative bariatric patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9k2s42	<NULL>	Patients who underwent bariatric surgery (BPYR) for at least 24 months will be included; aged between 18 and 60 years.	Patients with diabetes mellitus, pacemaker, decompensated thyroid dysfunction, or who present in the postoperative period malignant or consumptive disease (neoplasms, AIDS, liver diseases, nephropathies, heart failure and degenerative diseases), psychiatric disorders using psychotropic drugs, chronic use of corticosteroids, hormone therapy or medication for weight loss, presence of amputation and gestation, and patients who were on regular use of the protein supplement for less than 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7gm9zh	Effectiveness of Mindfulness as an adjunct to treatment in Therapeutic Communities.	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2646	Effectiveness of Mindfulness Based Relapse Prevention  as an adjunct to the treatment of substance use disorder: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-17	Universidade Federal de São Paulo UNIFESP	Fundação de Amparo a Pesquisa de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-7gm9zh	<NULL>	Men and women over 18 years of age who are literate (with ability to write and read in Portuguese); who have been on treatment for UUS in one of the services for at least fifteen days; who have consented to be randomized to one of the two groups (control or experimental) .	Patients with psychotic disorders diagnosed by the physician responsible for the services participating in the research or informed by the team for clinical knowledge prior to the patient&apos;s hospitalization; who present severe cognitive impairment that prevents the completion of the scales; patients with suicidal ideation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-2gycyv	Relationship between shoulder movement and muscle function with lesions of this joint in individuals practicing Crosstraining	Recruiting	Observational	2019-04-26	<NULL>	<NULL>	2647	The relation between the mobility of the shoulder complex and the scapulothoracic muscular function and its influence on the incidence of shoulder injuries in Crosstraining practitioners	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-2gycyv	<NULL>	Crosstraining practitioners between the ages of 18 and 60 who practice for at least 6 months will be included in the study to ensure that participants are familiar with the movements of the sport and with at least 24 hours of rest to avoid the influence of fatigue in the tests. The participation of the subject will be by signing the TCLE. Participants will be divided into 2 groups: Pain / Injury Group (GCD). Participants who present at least one of the criteria, EVA&gt; 5 at the start of the collection, indicate in the demographic questionnaire at least one of the three criteria that characterize musculoskeletal injury (total withdrawal of activity for more than 1 week; of normal training, such as duration, intensity or mode, for more than 2 weeks; physical complaint severe enough to require assistance from a health professional). For the Group without pain / injury (GSD). In this group, participants who present VAS &lt;5 at the beginning of the collection will not be included, reporting none of the definitions of musculoskeletal injury in the demographic questionnaire.	Participants who have a history of fracture or dislocation or who have undergone upper limb surgery, presence of neurological alteration that may influence muscle activation, individuals who practice other than Crosstraining sports involving throwing, weight or great range of motion of the shoulder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-29q75w	Benefits of an intervention with the use of an educational handbook in the support provided by caregivers in the delivery room	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2648	Effectiveness of intervention applied in maternity with use educational manual in the support provided by chaperone in delivery room	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Departamento de Enfermagem - Universidade Federal do Ceará	Maternidade Escola Assis Chateaubriand (MEAC)	https://ensaiosclinicos.gov.br/rg/RBR-29q75w	<NULL>	"The study population will be composed of two target groups: accompanying parturients who were admitted to the Maternity Center of the Maternity School Assis Chateaubriand (MEAC), between June and November of 2019; and puerperal women who have their companions involved in this research.
The population will be divided into two groups:
CONTROL GROUP (CG): group of accompanying persons eligible to participate in the research that will receive the routine guidelines, that is, guidelines performed in the delivery room by health professionals, academics, among others; as well as puerperal women who have their companions involved in this group. Thus, part of this group will be the puerperae and their respective participants who do not receive the educational intervention proposed by the researcher.
INTERVENTION GROUP (GI): group of companions to whom an intervention will be carried out using the educational manual; For this, after the accompanying person is authorized by the MEAC social service to accompany the delivery at the Obstetric Center; he will be invited to participate in the study and, if so, the educational intervention will be applied.
The joint reading of the manual has an average duration of twenty minutes, being interrupted to clarify doubts and questions made by the companion.

During the intervention, it will be agreed with the companion not to make the manual available to other people, clarifying the justifications for this fact.
The selection of the sample will follow the following inclusion criteria: be accompanying the choice of the woman patient; be accompanying nulliparas; have completed at least the fourth year of elementary school (level of education compatible with the readability index of Flash calculated for the manual evaluated here); as well as puerperal women who have companions with this profile; will also include all the puerperas who had, during the birthing process, the presence of companions who participated in this research in both groups."	"The exclusion criteria will be: to present a state of physical or mental health compromised in order to make data collection unfeasible; have previous experience of witnessing delivery as a companion; participate in another intervention in the institution (Ex.:Roda de Conversa)

The criteria for discontinuity will be: to accompany a parturient referred for cesarean section; give up participating in the study after the start of the collection; give up or be unable to follow labor / delivery; change of address and / or telephone that makes the contact unfeasible after the birth, if the only way to establish communication with the participant is by telephone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-5284zx	Taste umami in chemotherapy with platinum coordination drugs	Recruitment completed	Observational	2019-05-02	<NULL>	<NULL>	2649	Taste umami in chemotherapy with platinum coordination drugs	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-20	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-USP	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-USP	https://ensaiosclinicos.gov.br/rg/RBR-5284zx	<NULL>	"Study group:
over 18 years of age; undergoing QTX with platinum compounds at the Chemotherapy Center.

Control Group: 18 years; healthy; group formed by the companions of patients."	Smoking subjects, submitted to radiotherapy, with oral lesions, allergic to the test product (cream cheese and monosodium glutamate)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-8n7c9p	The effect of transcranial electrical stimulation on blood pressure	Recruiting	Intervention	2019-05-02	<NULL>	<NULL>	2650	Effects of direct current stimulation (tDCS) on ventricular variability and post-exercise hypotension in resistant hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-04	Fundação de Amparo à Pesquisa do Estado de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n7c9p	<NULL>	Men and women diagnosed with resistant hypertension, according to the latest international guidelines, be able to understand, verbalize and answer questions; agree to participate in the study and sign the Informed Consent Form, after clearly understanding it; adherence to non-pharmacological and pharmacological treatment. Patients such as mild to moderate hypertension will be included following treatment for comparison control.	Clinical history or clinical symptoms of heart failure; patients with dilated cardiomyopathies, valvulopathies or pericardial conditions; carriers of cerebrovascular disease or peripheral arterial disease, nephropathy, liver disease, smoking, autoimmune diseases and use of illicit substances; pacemakers or other electrical devices implanted in the body; any physical and / or mental limitation that impedes the performance of physical exercise or abnormal condition that may interfere with the results of the study according to the researcher&apos;s judgment; significant psychic depression (?17 on the Hamilton scale and current participation in another research study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4sntgt	Efficacy of dental anesthesia in retromolar canal.	Recruiting	Observational	2019-05-02	<NULL>	<NULL>	2651	Efficacy of dental anesthesia in patients with retromolar foramen observed through cone beam computed tomography.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de odontologia de Ribeirão Preto	Faculdade de odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4sntgt	<NULL>	retromolar presence;needed inferior alveolar nerve anesthesia	jaw bone lesions;oral mucosal lesions;lidocaine allergy 3%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-8zgtmd	"Evaluation of efficacy and safety of Penetro® solution for inhalation (eucalyptol, terpin
monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in 06-17 years-old children"	Not yet recruiting	Intervention	2019-05-02	<NULL>	<NULL>	2652	Evaluation of superiority on efficacy and safety of Penetro® solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in pediatric population 06-17 years old: a phase III, national, multicenter, double blind and randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-01	Centro de Pesquisa Clínica São Lucas	Synova Pesquisa Científica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8zgtmd	<NULL>	Participants greater than or equal to 06 and less than or equal to 17 years of age; Participant with symptoms of moderate or severe nasal congestion (ie, reaching at least 5 VAS) lasting at least 24 hours and a maximum of 48 hours prior to inclusion; Negative urinary B-HCG test for female participants after menarche; Participants able to understand and perform all study procedures and instructions; Participants must have the Informed Assent Form and the Informed Consent Form prior to any procedures related to the study.	Hypersensitivity to the active ingredients of study medication; Have used the study drug (Penetro®) at some earlier time; Total obstruction of one nostril by other etiologies that are not cooled or influenza, or for a period less than 24 hours and greater than 48 hours after the onset of symptoms; Bacterial Infectious etiology (diagnosed clinically); Participants on antibiotic treatment or anticipation of antibiotic use for another clinical condition; Intranasal corticosteroid use (7 days before study) or systemic (15 days before study), respecting the plasma half-life of the drug; Use of decongestants or intranasal or systemic antihistamines in the 3 days prior to the study; Participants taking inhaled or immunosuppressive drugs 7 days before the start of the study; Participants with grade II and III septum diversion, nasal polyps, severe congenital hypertrophy, adenoid hypertrophy, or other conditions that determine nasal obstruction; Chronic oral respirator with history for 6 months or more prior to study inclusion; History of surgery in the 3 months prior to the study; Female participants with a positive pregnancy outcome through the urinary hCG test; Participation in a clinical trial in the past 12 months; Other diseases that, at the discretion of the researcher responsible, may interfere with the results of the study; Mental incapacity or linguistic barriers or incapacity that, in the discretion of the researcher responsible, prevent the adequate understanding of the information of the Term of the Free and Informed Assent and the Informed Consent Form and the activities of the study; Known clinically significant systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6rngmb	Physiotherapy in the treatment of patients with Parkinson&apos;s disease through video game therapy	Recruiting	Intervention	2019-05-02	<NULL>	<NULL>	2653	Physioterapy in balance training of Parkinson´s disease pacients with Gametherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-11	Centro Universitário do Pará	Centro Universitário do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6rngmb	<NULL>	Participants with clinical diagnosis of Parkinson&apos;s disease (ICD 10: G20); both sexes; age range between 50 and 75 years; signature of the TCLE; Have performed a physiotherapeutic review that freed him for therapy.	Do not have closed clinical diagnosis; have signs of dementia ratified by the minimal; have other diseases that impair the ability to perform the exercises; hospitalization during the research; neoplasms under treatment; visual or auditory deficiency that may compromise the participant&apos;s interaction with virtual reality; traumatic and / or orthopedic injuries that influence the gait and performance of tasks required by the evaluation scales; patients with bracing or prosthesis in the musculoskeletal system; not appear on the day scheduled for evaluation; participants in physiotherapeutic treatment during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4cxw37	Effects of laying on of hands in heart sugery&apos;s patients	Recruiting	Intervention	2019-05-03	<NULL>	<NULL>	2654	Effects of laying on of hands in patients submitted to cardiac surgery: clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Escola de Enfermagem da Universidade de São Paulo	Pronto-Socorro Cardiológico Universitário de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4cxw37	<NULL>	Patients older than 18 years, with preoperative risk assessment classified as low or medium by Euroscore (SÁ et al, 2010). Thus, patients will have Euroscore 0 to 5 points	To affirm that it does not believe in the possibility that the imposition of hands may be beneficial to health, aortic or congenital cardiac diseases, emergency or emergency surgeries, the use of antipsychotics and anxiolytics, the impossibility of walking, mental and cognitive alterations that (concomitant stroke or sequelae, brain tumors, intracranial hypertension, cognitive and behavioral deficits, sensory-motor deficits), previous renal, digestive and pulmonary diseases, infections acquired before the surgical procedure; refusal to participate in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6wfxyn	Effects of a single dose of beet juice on the vessel function of patients with hypertension	Recruiting	Intervention	2019-05-03	<NULL>	<NULL>	2655	Acute effects of sugar beet intake on the vascular function of hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-20	Hospital Universitário Pedro Ernesto - HUPE	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ	https://ensaiosclinicos.gov.br/rg/RBR-6wfxyn	<NULL>	Patients of both sexes; age between 45 and 70 years; previous diagnosis of primary systemic arterial hypertension, signed the Informed Consent Term.	Secondary hypertension; systolic blood pressure greater than or equal to 180 mmHg or diastolic BP greater than or equal to 110 mmHg; in use of beta-blockers; with diabetes mellitus; history of cancer; in use of any dietary supplement; any serious life-threatening illness; cardiovascular diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-9djpfc	Resistance Training for Falls prevention in the Older Adults	Recruitment completed	Intervention	2019-05-03	<NULL>	<NULL>	2656	Resistance Training as a Strategy for Preventing Falls in the Older Adults: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal do Vale do São Francisco - Univasf	Universidade Federal do Vale do São Francisco - Univasf	https://ensaiosclinicos.gov.br/rg/RBR-9djpfc	<NULL>	"aged 60 and older;
physically inactive (structured exercise classes in the last 6 months);
absence of clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit;
no previously diagnosed cerebrovascular, neurological or psychiatric disease;
have sufficient visual and hearing capacity to complete cognitive assessment protocol;
not being under the use of hormone replacement therapy (women)."	"had clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit;
previously diagnosed cerebrovascular, neurological or psychiatric disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-2ffwzb	Effectiveness of smoking cessation treatment	Recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2657	Effectiveness of the Continued Approach to Cognitive Behavioral Therapy for Smoking Cessation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Escola Nacional de Saúde Pública Sérgio Arouca/Fundação Oswaldo Cruz	Escola Nacional de Saúde Pública Sérgio Arouca/Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-2ffwzb	<NULL>	The general selection criteria for inclusion of all the research participants will be: age greater than or equal to 18 years old; be a smoker; be a volunteer candidate to join the Smoking Control Program of the Centro de Saúde Escola Germano Sinval Faria.	Those younger than 18 years old; those who are not smokers; those who are not volunteer candidates to join the Smoking Control Program of the Centro de Saúde Escola Germano Sinval Faria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6vp3hq	Contributions of dance in the quality of life of the elderly	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2658	The dance as a resource of the occupational therapist with the elderly: contributions in the quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-16	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6vp3hq	<NULL>	Age equal or superior to 60 years; of both genders; have four years or more of schooling; without cognitive deficits by the Mini Mental State Examination; without neuromotor deficiencies reported; without related cardiac and respiratory problems.	Be less than 60 years old; have indicative of cognitive deficits by the Mini Mental State Exam; have less than four years of schooling; to present neuromotor deficiencies; have heart and respiratory problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7zphsf	Effects of Evaluation of Exercise Capacity at the level of daily physical activities of adults of the community	Not yet recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2659	Effects of the Avaluation of Cardiorrespiratory Fitness at the level of activity and physical fitness of adults of the community	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal São Paulo	Universidade Federal São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zphsf	<NULL>	Age from 18 years; without diagnosis of cardiorespiratory, metabolic or neuromuscular diseases that prevent the performance of physical exercises	Basal cardiorespiratory fitness greater than 9 METs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4ytnzx	Evaluation of the impact of care provided by professional caregivers on the burden of family caregivers of dependent elderly: study with random sample and control group.	Recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2660	Effectiveness of care provided by a professional caregiver in reducing the burden of family caregivers of dependent elderly: randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4ytnzx	<NULL>	The sample consists of 60-year-olds and more of both sexes, who presents disability in two or more ADLs. All of them must have a family caregiver who was responsible for supervising and caring for most of the elder&apos;s activities.	Elderly people with mild dependency (one or two ADLs), who live alone, even if they are dependent or who have irregular care, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6q23nk	Effectiveness of Proerd (Education Program on Drug and Violence Resistance)	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2661	Effectiveness evaluation of the Education Program on Drug and Violence Resistance (PROERD) from de Militar Police of São Paulo State	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-25	Universidade Federal de São Paulo - UNIFESP	Polícia Militar de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6q23nk	<NULL>	No application of PROERD in the schools of São Paulo in the last 3 years	Non-student consent in completing the research instrument; application of the PROERD program in schools in the last 3 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-6y3q6c	Comparison of a protocol for the training of pelvic floor muscles isolated and associated with the electrostimulation of posterior tibial nerve for mixed urinary incontinence: a clinical trial randomized and blind	Recruitment completed	Intervention	2019-05-06	<NULL>	<NULL>	2662	Comparison of a protocol for the training of pelvic floor muscles isolated and associated with the electrostimulation of posterior tibial nerve for mixed urinary incontinence: a clinical trial randomized and blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6y3q6c	<NULL>	To present urinary incontinence, have not performed any previous physiotherapeutic treatment for pelvic dysfunctions, do not have pacemakers or cardiovascular diseases and are not pregnant.	Women presenting with an infectious condition, who present with a grade III or IV prolapse, who complain of unbearable pain at physical examination of pelvic floor muscle strength and who present more than 3 absences during the treatment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4wwj5c	Characterization of heartbeat and motor functions in people with spinal cord injury	Recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2663	Characterization of autonomical modulation and the functional profile of people with spinal cord injury	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wwj5c	<NULL>	All patients who are in clinical follow-up at Acreditando, Neuromotor Recovery, Health and Welfare Center and carrying the authorization of parents or guardians to participate in the study, with medical diagnosis of spinal cord injury, will be considered eligible.	Patients with cardiac arrhythmias and atrioventricular block, congenital anomalies, such as congenital heart diseases, pulmonary malformations, and patients using drugs that interfere with autonomous nervous system, such as antiarrhythmic drugs and drugs for the treatment of diabetes mellitus, such as insulin, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4xtw6z	Anesthesia of the  quadratus lumborum muscle guided by ultrasound as exclusive method of anesthesia in the correction of the Inguinal Hernia by videolaparoscopy	Recruitment completed	Intervention	2019-05-07	<NULL>	<NULL>	2664	Ultrasound guided quadratus lumborum block as an exclusive method of anesthesia on Extraperitoneal Laparoscopic correction of Inguinal Hernia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Santo Amaro	Instituto de responsabilidade social sirio libanes - hospital geral do grajau	https://ensaiosclinicos.gov.br/rg/RBR-4xtw6z	<NULL>	Patients with unilateral inguinal hernia, without severity criteria, ASA (American Society of Anesthesiologists) 1-2, aged between 18 and 80 years. During outpatient care, a quality of life questionnaire was applied prior to surgery, evidencing pain patterns and restrictions on preoperative activities.	Surgery time over 120 minutes, surgical complications such as bleeding, infection or conversion to open surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4qn7zg	Clinical efecctiveness and tooth sensitivity of two sorts at-home bleaching treatment	Recruiting	Intervention	2019-05-07	<NULL>	<NULL>	2665	Clinical efecctiveness and tooth sensitivity of at-home bleaching treatment with 35% carbamide peroxide versus 10% carbamide peroxide- a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4qn7zg	<NULL>	Patients who have minimum age 18 years old; good general and oral health; health vital teeth. According to Vita Classical scale, the teeth must be A2 or darker. It will be necessary that pacients agre the free informed consent form (TCLE).	Volunteers who have already undergone dental bleaching, who have dental prostheses, visible enamel cracks. Pregnant or lactating; with previous dental sensitivity history; possessing dental dimming due to pathologies or use of medications; in orthodontic treatment; who are on medication that may reduce tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-29x2pr	Cell Therapy in Women&apos;s Health	Recruiting	Intervention	2019-05-07	<NULL>	<NULL>	2666	The use of human stem cells for the treatment of stress urinary incontinence in women.	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-29x2pr	<NULL>	"Inclusion criteria.
1. Patients with moderate primary and refractory stress urinary incontinence confirmed by stress cough test; or during urodynamic study; or during the pad test."	"Exclusion Criteria
Patients with prolapse of anterior or uterine vaginal wall greater than stage 2 POP-Q;
Patients submitted to surgical procedures to repair previous SUI;
Patients with genital malformations that make it impossible to inject at the site of
middle third of the urethra;
Patients submitted to previous pelvic radiotherapy;
Patients who during clinical evaluation or urodynamics present other
diagnoses that not only SUI;
Patients who did not agree to participate in the study at any stage or the ones who are not able to read, write and understand the study;
Patients &lt;18 years of age."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-6sv58t	Electroconvulsive therapy in the treatment of psychological trauma	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	2667	Post-retrieval electroconvulsive therapy in the treatment of conditioned fear.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-6sv58t	<NULL>	Age 18 to 65. Complete diagnostic criteria for posttraumatic stress disorder (PTSD) by the DSM-IV. Identified by applying the Structured Clinical Interview for DSM Axis I Disorders. Meets the criteria of gravity and refractory to traditional treatments for PTSD, formulated on the basis of two studies that have shown efficacy and safety of therapeutic modality for PTSD (Helsley et al., 1999;. Margoob et al, 2010) or present clinical indication for ECT because of comorbidities. Provide skin conductance response and. To be able to understand and nod with the free and informed consent.	Have made abusive or recreational use of substances (except nicotine) less than 72 hours in the experimental days. Present relative contraindications to the use of ECT.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4s8qjx	Effect of soft silicone foam dressing compared to film transparent dressing in Pressure Ulcer prevention	Recruitment completed	Intervention	2017-08-31	<NULL>	<NULL>	2668	Randomized clinical trial about multilayered soft silicone foam dressing to transparent polyurethane film Effectiveness in Pressure Ulcer prevention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-22	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-4s8qjx	<NULL>	over 18 years old; high risk and very high risk for developing pressure ulcer from the Braden scale; has been evaluated by the researcher within 24 hours of hospitalization; show the heels pair healthy	allergy to the research product; being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4yht9x	Effect of a Planned Exercise Program on Physical Values and Quality of Life in Women with Breast Cancer Performing Neoadjuvant Chemotherapy	Not yet recruiting	Intervention	2019-05-23	<NULL>	<NULL>	2669	Effectiveness of a Structured Physical Exercise Oriented Program on Strength, Cardiorespiratory Fitness and Quality of Life in Women with Breast Cancer Submitted to Neoadjuvant Chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte - UFRN	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-4yht9x	<NULL>	Adult individuals; women; sedentary; age between 20 and 59 years; diagnosed with breast cancer; computed tomography scan of the abdominal region available on your chart; did not perform the first cycle of neoadjuvant chemotherapy.	Patients with metastatic disease; symptomatic cardiac or pulmonary disease; psychiatric; with intellectual physical incapacity to understand the stages of the research; in vulnerability to consent their participation or that do not obtain release of the oncologist to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-5fjprw	Short-term effects of a myofascial release made by the individual with a roll, sensation of pain at the pressure, movement, and muscular strength of posterior thigh	Recruitment completed	Intervention	2018-12-13	<NULL>	<NULL>	2670	Immediate effects of myofascial self-release with roller on pain threshold at pressure, range of motion and hamstring strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5fjprw	<NULL>	Healthy adult volunteers; both genders; age between 18 and 30 years; weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	Volunteers with a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; with lesions of the central nervous system, established deformities of lower limbs; previous hamstring muscle injury in the assessed limb; inflammatory processes established in the segment. Be performing physiotherapeutic treatment in progress; in concomitant participation in competitions and; with flexibility that exceeds the limits of the evaluation apparatus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5h983f	Exercise therapy on cording after breast cancer surgery	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2671	Physical therapy treatment of axillary web syndrome dysfunctions: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-14	Hospital Universitário de Brasília	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5h983f	<NULL>	Women over 18 years old; who underwent unilateral breast cancer surgery; with reduced range of motion compared to the contralateral limb due to axillary web syndrome; with  pain in the upper limb due to axillary web syndrome.	Inability to read; stage IV breast cancer; lymphedema; active infection in the area to be treated; dehiscence; deep venous thrombosis; physical or mental conditions that interfere in the assessment and / or treatment proposal; unavailability for weekly physiotherapeutic intervention for four weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4rqnj3	"Patient Rehabilitation Program with Lombalgia: influence
in disability scores, heart rate variability, fear, Anxiety, Depression and Resilience"	Data analysis completed	Intervention	2018-06-05	<NULL>	<NULL>	2672	"Patient Rehabilitation Program with Lombalgia: influence
in disability scores, heart rate variability, fear, Anxiety, Depression and Resilience"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-04	Universidade Federal do Maranhão	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-4rqnj3	<NULL>	Lower back pain for at least six months; disability score assessed by the oswestry index 20%; be between 18 and 65 years old; have at least six years of schooling; be able to understand and verbalize; be available to attend the program meetings	Individuals who were submitted to lumbar spine arthrodesis; who use walking aid for locomotion; Acute and oncological diseases; Major heart disease that limits rehabilitation activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-3bskgt	The influence of meditation focusing on breathing in the anxiety in LGBT	Not yet recruiting	Intervention	2018-10-03	<NULL>	<NULL>	2673	The influence of meditation practice focusing on breathing in the signs and symptoms of anxiety in the LGBT population	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-15	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3bskgt	<NULL>	"The criteria for inclusion for students participating in the meditation group is older than 18 years, be student of UFAL (Federal University of Alagoas) and LGBT; be showing signs and symptoms of anxiety through MINI (MINI International Neuropsychiatric Interview) and/or IDATE (State trait anxiety inventory).
For the control group, the inclusion criteria will be the same."	"Will be deleted the students who refuse to participate in the study; who have more than one absence per month in the meditation; those who do not fulfil the daily meditation and those who give up graduation during meditation practice.
For the control group, the exclusion criteria will be the same."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5bch9m	Effect of the use of cellular application for adhesion to treatment of adolescents with Diabetes Mellitus 1	Not yet recruiting	Intervention	2019-06-03	<NULL>	<NULL>	2674	Effectiveness of a mobile application for the clinical and educationalcare for adhesion to treatment of adolescents with Diabetes Mellitus 1: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Eline Saraiva Silveira Araújo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5bch9m	<NULL>	The population will be comprised of adolescents between 12 and 17 years old; with DM1 in follow-up at the Integrated Center for Diabetes and Hypertension (ICDH).	Those who do not appear during the data collection period or who do not have a smartphone and / or mobile internet will be excluded. There may be losses due to death or a change in the service location.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-359xvj	Application of transcutaneous electrical nerve stimulation in individuals with temporomandibular dysfunction	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2675	Transcutaneous electrical stimulation in TMD analgesia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-13	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-359xvj	<NULL>	Men and women; aged between 18 and 55 years; who presented signs and symptoms of temporomandibular myogenic dysfunction	Do not present pain in the masticatory musculature, history of systemic rheumatic disease, or were taking analgesic and / or anti-inflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-8nnpfm	Human milk lyophilisate - Phase 1 and 2 study: safety, tolerability and effectiveness	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2676	Nutrition of very low birth weight preterm newborns using a concentrate with human milk lyophilisate - phase 1 and 2 study: safety, tolerability and effectiveness	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-05-07	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8nnpfm	<NULL>	It will be included in this study, very low birth weight newborns (VLBWN) who were admitted to the Intensive Care Units and Neonatal Intermediate Care of the Children’s Hospital of Ribeirão Preto Medical School - University of São Paulo (HC-FMRP-USP). Parent or legal guardian needs to sign the informed consent to participate in the research. Inclusion criteria for LBWN are: male and female sexes; who had birth weight &gt;= 750 grams and &lt;= 1500 grams in Phase 1 and less than or equal to 1500 grams in Phase 2; from any ethnicity; prematurely born (less than 37 weeks of gestational age); considered small (SGA) or adequate for gestational age (AGA); receiving human milk, whether raw maternal (which will be kept) and / or human milk from the bank in the volume of 100 ml / kg / day; whose mother, father or legal guardian authorizes participation in this study and, thus, signed the Free and Informed Consent Form; in a situation of twinning, one of the newborns will be drawn for each group; stable hemodynamically, without use of vasoactive drugs.	The exclusion criteria (Phase 1 and Phase 2) will be: newborns considered large for gestational age; that presence of major malformations; periventricular and intraventricular hemorrhage (HPIV) degrees III and IV; children of minor mothers without accompanying.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-7ymz2q	Strategies to Optimize Access to the vaccine against Pneumonia among adults	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2677	Strategies to optimize the access of adults with clinical indications to the 23-valent Pneumococcal Polysaccharide Vaccine within the Brazilian National Public Health System.	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-01	UNESP	DIVISAO DE IMUNIZACAO DA COORDENADORIA DE CONTROLE DE DOENCAS DA SECRETARIA DE ESTADO DE SAUDE DE SAO PAULO	https://ensaiosclinicos.gov.br/rg/RBR-7ymz2q	<NULL>	"The only inclusion criterion was that the municipalities participating in the study belonged to the reference area of the Reference Center for Special Immunobiologic Products (RCSIP) of Botucatu, state of Sao Paulo. The municipality of Jahu was chosen as the municipality for implementation of the study intervention by convenience. We used as controls the remaining 69 municipalities belonging to the same RCSIP. 

Note: The present study used a strict administrative intervention at the ecological level. The sample size described in the previous item refers to an estimate of the population residing in the study areas."	There are no atiditional exclusion criteria beyond what was informed under inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-7hqk8t	Effect of Training Functional Activities on biological factors after Stroke	Recruitment completed	Intervention	2018-01-26	<NULL>	<NULL>	2678	Efficacy of Task-Specific Training in changing neurotrophic factors and impact on clinical outcomes in individuals with Stroke: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7hqk8t	<NULL>	Volunteer with clinical diagnosis of primary or recurrent cerebrovascular accident for more than six months; aged 18 years or over; with the capacity to independently roam more than 10 meters with or without gait; sedentary lifestyle or who are insufficiently active; with medical release for the practice of physical activity.	Patients with cognitive impairment (Mental State Examination) will be excluded; with a history of severe heart disease and uncontrolled blood pressure; with presence of pain or pathology that interferes with the intervention, such as vestibular disorders, severe arthritis or any disease of the nervous system; that do not allow or fear the collection of blood; who have made use of anti-inflammatory drugs in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-6nrt3x	Respiratory muscle exercise with Power Breathe® and Respiron® in healthy people	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2679	Respiratory muscle training with Power Breathe® and Respiron® in healthy subjects	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2018-08-10	Pontifícia Universidade Católica de Goiás	Pontifícia Universidade Católica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6nrt3x	<NULL>	Age between 18 and 59 years, who present normal spirometry.	Individuals with cardiac disease; pulmonary; neurological or cognitive; smoking; retinal detachment; glaucoma; recent ophthalmic surgeries as well as corticosteroids; bronchodilators and ergogenic supplements; will be excluded from regular physical activity for less than three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-3h95h7	The effect of Transcranial direct current stimulation on Numerical abilities of children and adolescents with brain injury	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2680	Use of transcranial direct current stimulation in children and adolescents with cerebral palsy: effects on numerical cognition	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2015-06-10	Centro Paulista de Neuropsicologia	Centro Paulista de Neuropsicologia	https://ensaiosclinicos.gov.br/rg/RBR-3h95h7	<NULL>	(a) age between 8 and 14 years, (b) diagnosis of hemiplegic or diplomatic cerebral palsy, (c) they are enrolled in regular schools and have no school delay for more than two years, (d) complaint of difficulties in learning math.	use of medication with action on the central nervous system; diagnosed psychiatric, genetic, metabolic or degenerative disease; epilepsy; sleep disorders; congenital malformations; IQ of less than 75	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5zcggj	3D glasses may improve adherence to treatment in Glaucoma patients that use only one eyedrop. A clinical study.	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2681	3D virtual reality may enhance adherence in glaucoma patients using monotherapy - a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-10	HCloe Clinica Oftalmológica Especializada	HCloe Clinica Oftalmológica Especializada	https://ensaiosclinicos.gov.br/rg/RBR-5zcggj	<NULL>	We included glaucoma patients with age equal to or above 18; who were already being treated at our clinics; with the minimal visual acuity 20/40 according to the Snellen table	The exclusion criteria included an age of fewer than 18-years-old; the demand for surgery during the three-month evaluation period; corneal diseases that interfered with the accurate measurement of intraocular pressure (IOP);  retinal diseases that impeded the quality of an optical tomography coherence exam (OCT) and computer perimetry.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5cnyjj	Single implant prosthesis	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2682	Single oral implant rehabilitation	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-20	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5cnyjj	<NULL>	"Patient in need of rehabilitation with unitary implants in a region that is apparent in his smile;
Patient with healthy natural homologous tooth, restored or rehabilitated with fixed crown on tooth;
Patient with balanced occlusion and no pathological signs."	"Patient with prosthetic space of two or more contiguous teeth
Absence of occlusal stability
Homologous with change of color and shape."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-843pth	Effects of Vitamins&apos; Supplementation on strength gains following Physical Training in Breast Cancer survivors	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2683	Effects of antioxidant supplementation on strength training-induced neuromuscular adaptations in breast cancer survivors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Centro Universitário de Brasília - UniCEUB	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-843pth	<NULL>	"The sample of the present study will be comprised of 40 survivors of breast cancer referred to the chemotherapeutic, radiotherapeutic and / or surgical treatment in the public and / or private hospital network. 
Must be female;
Have been diagnosed with stage I to IIIC breast cancer (1, 3);
Have completed radiotherapy and / or chemotherapy for at least six months; 
Have not been involved in exercise programs for at least six months."	"Metastatic cancer;
Cardiovascular and/or metabolic/ and/or muscular dysfunctions;
Secondary cancers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-42v548	Treatment by low level LASER in the roof of the mouth in patients with snoring and sleep apnea	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2684	Photobiomodulation by low level LASER therapy in patients with obstructive sleep apnea	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-42v548	<NULL>	Score in two or more positive categories in the Berlin Questionnaire; when performing the polysomnography examination, the apnea and hypopnea index should be greater than or equal to 15 events per hour of sleep (AHI&gt; 15 / h).	Pediatric, eudaphic and elderly patients; patients with diagnosed central apnea; alcoholic patients, smokers, oncologists, pneumopathies, patients with heart disease and with hypothyroidism; pregnant women; or patients with a history of photosensitivity (allergic). Participants unable to understand and sign the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9gnkr2	Impact of low electrical stimulation on the scalp and physical training on the adaptations of the system that regulates body functions in patients with weakness on one side of the body resulting from a stroke.	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2685	Impact of Transcranial Direct Current Stimulation and physical training on the autonomic adaptations in hemiparetic patients due to the Stroke: Clinical Trial, Controlled, Randomized, Double-blinded	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-08	UNINOVE	CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9gnkr2	<NULL>	To present hemiparesis due to stroke for more than 6 months; Mild or moderate motor impairment determined by the Fugl-Meyer test with lower limb scores between 20 and 31 points; Comfortable walking speed in the ground between 0.3 and 1.15 m / s; Classification between levels 04 to 06 in Functional Mobility Scale (FMS) - Functional Mobility Scale and ability to perform exercise on the bicycle; Presentation of AVC provings; Signature of science regarding the term of free and informed consent (TCLE); Blood test (hematological and biochemical); Image examination of lesion location; The use of beta blockers will not be considered an exclusion factor due to the large percentage of patients taking this drug, a separate analysis will be performed to see if there are baseline differences in the other patients.	To present cognitive deficits in the Mini Mental State Examination (MMSE) with scores below 17 points; Visual impairment that may interfere with the performance of the tests; Severe cardiac problems (congestive heart failure, angina, peripheral vascular disease), use of pacemaker; Contraindications to the use of CTEE (brain implant of metal clips near the area to be stimulated, history of recurrent seizure, recurrent epilepsy and brain tumors, cerebral pacemaker, bore or cracks in the cranial cavity, cutaneous lesions near the area to be stimulated and / or metal plates or devices at the ETCC stimulation site); Irregular menstrual cycle or being in the menstrual period during the evaluation; No medical certificate for the aerobic exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9wddjb	Physiotherapeutic evaluation of pregnant women practicing Pilates	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2686	Cardiorespiratory, musculoskeletal and aesthetic evaluation of pregnant women practicing the Pilates method	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-9wddjb	<NULL>	Medical authorization containing release for the practice of exercises; physiological gestation with a live fetus; gestational age above 16 weeks; physiological puerperium.	chronic-degenerative diseases; high-risk gestation; presence of any pregnancy-related pathology (polyhydramnios, pregnancy-induced hypertension (HAIG); previously diagnosed or any contraindication to physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-4dx8n4	Treatment of pain in the thoracic gorge with anesthetic injection.	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2687	Evaluation of the efficacy of Ropivacaine injection in the anterior and middle scalene muscles guided by ultrasonography in the treatment of Thoracic Outlet Syndrome.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2012-07-30	Instituto de Medicina Fisica e Reabilitação - IMREA -  HCFMUSP	Instituto de Ortopedia e Traumatologia – IOT da Faculdade de Medicina da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-4dx8n4	<NULL>	this study were subjects with a diagnosis of nonspecific, Thoracic Outlet Syndrome who included criteria for inclusion with pain in upper limbs and / or neck pain without radiculopathy or neurological impairment of the limb in question due to compressive or encephalic root causes.	"Clinical instability with acute medical conditions.
Hypersensitivity to administered medication.
Injury of the rotator cuff previously diagnosed by some imaging examination and justifying pain.
Fibromyalgia previously diagnosed."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-9tvfk2	"Effect of GPR 
on rehabilitation  and sleep after stroke"	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2688	"Effect of Global Posture Reeducation 
on rehabilitation  and sleep after stroke"	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-20	Fundação de Amparo à Pesquisa do estado de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9tvfk2	<NULL>	Patients of both sexes, with age greater than or equal to 18 years of age; Patients with Apnea and Hypopnea Index ? 15;  Patients with a history suggestive of a first acute stroke will be invited or may apply to participate in the study; Subacute stage of stroke (between 30 days and 3 months after disease onset); Magnetic Nuclear Resonance or Computed Tomography of the brain performed after hospital admission demonstrating ischemic or hemorrhagic stroke; Patients with NIHSS scores for stroke between 5 and 20 (moderate to moderate / severe stroke-motor impairment) at the time of entry study evaluation; Availability of attendance at physical therapy and assessment sessions; Accept in participating in the study and signing the Informed Consent Term (TCLE).	Patients with other associated neurological or sleep disorders that interfere with rehabilitation;Patients with renal insufficiency; Previous presence of stroke, subarachnoid hemorrhage or due to secondary cause, malformation, vasculitis, brain tumor or head trauma; Use of potent sedative drugs or continuous sedation; Patients with associated restrictive pulmonary or peripheral vascular diseases; Patients with congestive heart failure or class III or IV heart failure of the New York Heart Association Functional Classification; Non-cooperative patients due to lowering of level of consciousness, impairment of language, vision or important cognitive (verified by Montreal Cognitive Assessment (MoCA, Simões et al, 2008); Previous sleep breathing disorders under treatment; Patients who miss physical therapy sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-34mxpw	Effects of a program that assists parents in their child&apos;s education	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2689	Effects of a program to promote positive parenting practices in a socially vulnerable context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Medicina de Botucatu	Secretaria Municipal de Assistência Social  de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-34mxpw	<NULL>	part of the &quot;Cheers Milk&quot; program	caregivers of children under 2 years old; people with significant cognitive and/or emotional difficulty; more than 3 absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-55zbhb	Influence of osteopathic treatment on the autonomic nervous system of patients with chronic low back pain	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2690	Effects of osteopathic manipulative treatment on the neurovegetative system of patients with chronic low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Renan Omil Pravatta Pivetta	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-55zbhb	<NULL>	Age between 18 and 65 years of age; low back pain on most days for at least 3 months with numeric scale of pain greater than 3.	Upper motor neuron alterations; severe osteoporosis; progressive neurological deficit; positive Laségue test below 35 °; inability to complete the questionnaires; previous lumbar surgery; autoimmune diseases; neoplasms; pregnancy or withdrawal by the INSS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-7yx36h	Impact of a nutritional intervention on overweight pregnant women under neonatal adiposity, child development and maternal postpartum weight retention	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2691	Impact of a nutritional intervention on overweight pregnant women under neonatal adiposity, child development and maternal postpartum weight retention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Centro de Saúde Escola - Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7yx36h	<NULL>	Newborns of pregnant women included in the intervention study.N	Newborns with fetal malformation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-2wgrxr	Evaluation of a Training with Physiotherapeutic Exercises in the Elderly	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2692	Evaluation of the Neurofunctional Gain and Quality of Life of Elderly Patients submitted to Physiotherapeutic Care based on Multisensory Training	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-2wgrxr	<NULL>	elderly; both sexes; aged 60 or over; participate in some program carried out at UBS.	Did not present a cognitive level that would guarantee the understanding of the instruments of the study; wandering with auxiliary devices; perform another type of physical exercise concurrently; diagnosis of vestibular syndrome, visual impairment or any neurological disease and / or skeletal muscle that compromises locomotion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-5rcknr	Comparison of different antibiotic vancomycin administration regimens in patients with impaired renal function and need for dialysis	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2693	Comparison of different vancomycin administration regimens in patients with acute kidney injury in hemodialysis therapy: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-5rcknr	<NULL>	septic patients hospitalized in the intensive care sector of Clinics Hospital of Botucatu Medical School -  UNESP; over 18 years old; with AKI and clinical presentation suggestive of acute tubular necrosis (ATN) associated with sepsis; in acute renal support and using vancomycin	pregnant women, patients with AKI of other etiologies; patients who are on chronic renal replacement therapy (dialysis or renal transplantation); patients who have had their dialysis session interrupted for clinical or technical reasons; and patients with serum pre-dialysis seric levels of vancomycin greater than 25 mg/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-4sn2n6	Bucket bath in newborns	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2694	Effects of Hydrotherapy on Weight Gain in Preterm Infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4sn2n6	<NULL>	The study will include patients with gestational age between 30 and 35 weeks; between 7 and 28 days of life; clinically stable; using enteral diet;	"Will be excluded from the study newborns using ventilatory support; with neurological impairment; diseases of the digestive tract; gastrointestinal fasting; changes in the thermoregulatory system, children of mothers diabetic patients with syphilis or hepatitis B and without the signature of the parents and
free and clear;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-4c47pt	Development of a liver&apos;s drug at Hospital das Clínicas	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2695	Development of ursodeoxycholic acid 300 mg at Hospital das Clinicas of FMUSP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-19	Hospital das Clínicas	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c47pt	<NULL>	Diagnosis of Primary Biliary Cholangitis; Male or female; 18 years old; and atients on regular treatment for at least 6 months with commercial drug (Ursacol)	"Any other co-existing liver diseases; pregnancy; 
-withdrawal of consent; patients not adherent to treatment with reference drug and known intolerance to the study drugs"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-78c25h	Evaluation of safety and efficacy of a new minimally invasive procedure for weight reduction through gastric fundus ischemia.	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2696	Bariatric embolization: Safety and efficacy in weight reduction in patients with body mass index between 30 and 39,9	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-07	Hospital Federal de Bonsucesso	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-78c25h	<NULL>	Ten patients, females, over the age of 18 and under 50 years old; with a diagnosis of obesity grades 1 and 2 and Metabolic Syndrome .	Individuals weighing more than 180 kg; pregnant or wishing to become pregnant within the next six months; with history of gastric surgery, alcoholism or previous drug abuse; with coagulation disorder and presence of advanced heart, lung or liver disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-4hcvsg	Effect of infrared laser after office bleaching to reduce dental sensitivity	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2697	Effect of low power laser for reduction of bleaching-induced tooth sensitivity after in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4hcvsg	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-9fwkpk	Sleeping problems and factors associated in children and adolescents in the metropolitan region of Recife	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2698	Sleep Disorders and associated factors in children and adolescents of the metropolitan region of Recife	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-06	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9fwkpk	<NULL>	"Be 7 or 11 years old;
Present posterior crossbite (uni or bilateral) and / or atresic palate (ogival)
Present moderate to high risk of airway compromise assessed through questionnaire (Sleep Disorder Scale in children)."	Children with chromosomal syndromes, acute or chronic neuromuscular disease and previous history of any type of orthodontic and / or surgical treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-2qvnq9	Effect of Probiotics on intestinal health in adults and healthy adults	Recruitment completed	Intervention	2019-06-04	<NULL>	<NULL>	2699	Effect of Probiotics on intestinal health in adults and healthy adults: Influence of the type of cepa, dose and method of administration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-13	Patrícia Borges Botelho	Cifarma Científica Farmacêutica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2qvnq9	<NULL>	Men and women aged 19-70 who have low evacuation frequency (2-4 days \ week) and general abdominal discomfort	Volunteers who have diagnosed diseases in the GIT or complications of surgeries resulting from these diseases; presence of hepatic or renal dysfunction; those who have used antibiotics in the last four weeks. Have used in the last four weeks drugs or vitamins or minerals or herbal foods or supplements to reduce digestive symptoms. Those who consumed food containing probiotics and prebiotics before and during the intervention. Volunteers consuming nutraceutical foods with anti-inflammatory activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-5c8y6v	The Wound action effects of a Simple Suction Dressing	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2700	A Simplifield Vacuum Dressing System: a Randomised Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Hospital Geral Roberto Santos	Instituto de Ciências da Saúde da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5c8y6v	<NULL>	Healthy volunteers; persons hospitalized at the reference unit (General Hospital Roberto Santos), both genders; age greater than 18; contaminated and / or dirty wounds that are not responding in terms of cleaning to usual dressings (eg gauze, antibiotic ointments)	Diagnosis of decompensated or severe systemic disordens (cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic, morbid obesity, severe anemia, hemodynamic instability); previous use of one of the dressings studied; untreated infection or infection with systemic repercussion;  unfavorable wounds(perilesional dermatoses, wounds associated with fistulas, malignant neoplasm of the wound, wounds with exposure of vessels, nerves or viscera, periorificial wounds); use of immunosuppressants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-7wxsqv	Reference values for oxygen supply levels and use of Near_Infrared Spectroscopy (NIRS) in individuals with Diabetes	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2701	Reference values for tissue perfusion levels and use of Near-Infrared Spectroscopy (NIRS) in individuals with Diabetes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-7wxsqv	<NULL>	Individuals of both sexes will be included; type 2 diabetics; above 18 years of age; that do not have any musculoskeletal changes or comorbidity that impedes the physical effort of the proposed stress test; and who present the medical release to participate in the study.	Individuals with an inability to understand or perform any proposed test will be excluded from the sample, those with an ankle-brachial index (ABI) of less than 0.90 or greater than 1.40 and those who withdraw their consent to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3cxz39	Effects of simulation on the performance of health information systems	Recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2702	"Dissemination of technological innovation: Information System of the National
Immunization"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-3cxz39	<NULL>	"Nursing professionals working in the vaccination room with the Information System of the National Immunization Program implemented; nurses working in the vaccination ward for at least six months should have a knowledge of the work in the vaccine room and that express interest in
participate in the study."	Those professionals who do not carry out activities in the vaccine room and who do not want to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-7k6xvc	Impact of weekly speech therapy in the rehabilitation of stroke patients with swallowing disorders	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2703	Impact of weekly speech therapy in the rehabilitation of stroke patients with Dysphagia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-14	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-7k6xvc	<NULL>	"medical diagnosis of stroke;
dysphagia after stroke;
use of enteral probe for feeding; 
40 years or more."	"neoplasias;
patients who lived in places where it would be impossible to access through the means of transportation used in the home care programs of the two hospitals."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3bhhtg	Evaluation of the influence of office dental whitening on pulp	Recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2704	Evaluation of the pulpar vascular response after office dental whitening: randomized clinical test	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-06-01	Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior- CAPES	Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior- CAPES	https://ensaiosclinicos.gov.br/rg/RBR-3bhhtg	<NULL>	Volunteers between 18 and 30 years of age; regardless of gender or ethnicit; who present good oral and general health; who agree to participate in the study and present in the two arches all the anterior teeth until the second premolars. Have at least one of the anterior-superior teeth classified as A2 color or lower value compared to the Vita scale.	Individuals with caries and restorations in the region between the premolars; who underwent orthodontic treatment; who require dental extractions in the anterior region; who have already undergone previous bleaching treatment; pregnant women; infants; severe discoloration (tetracycline, fluorosis); teeth with endodontic treatment; non-carious cervical lesions; parafunctional habits; previous sensitivity; periodontal disease; smokers; use of anti-inflammatories in the last 3 months; antibiotics; antifungals or any other drug that causes effects on blood action.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-2fqwqy	Sociodemofraphic characteristics and pain assessment through  the Mcgill questionnaire in women with Primary Dysmenorrhoea submitted to Auriculotherapy	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2705	Auriculotherapy in the Treatment of Primary Dismenorriation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Associação Teresinense de Ensino SC LTDA	Associação Teresinense de Ensino SC LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2fqwqy	<NULL>	The study included women with sedentary ages ranging from 18 to 25 years old with PD diagnosis; according to the nondigorous PD guideline; with a history of a regular menstrual cycle (cycle of 27 to 32 days); non-smoker; with availability of time to perform Auriculotherapy applications; not to perform other physiotherapeutic treatments; and those who accepted to participate in the research by signing the Informed Consent Term (TCLE).	Women with other physical illnesses causing pain; history of pregnancy and / or severe heart; gynecological or autoimmune diseases; in use of any psychotropic drug or hormonal contraception in the last six months; as well as, subjects submitted prior to acupuncture treatment; volunteers with needle phobias and participants who did not respond fully to the sociodemographic questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-5sv6r8	Influence of isolated strength training and dual task strength training for the elderly: morphofunctional, cognitive adaptations and blood concentrations of brain-derived neurotrophic factor	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2706	Dual-task Strength training: morphofunctional, cognitive and hormonal adaptations in healthy elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-19	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5sv6r8	<NULL>	Age equal or superior to 60 years; not part of a structured, systematic and organized program of physical exercises; have a score equal to or higher than 20 points in the mini mental state examination (MMSE); walk independently; make available for the participation of a four-month exercise program	Physical and / or cognitive impairment to prevent physical exercise; history of heart disease (e.i. acute myocardial infarction), neurological (e.g. Alzheimer&apos;s disease), psychiatric (e.i. schizophrenia),cerebrovascular (e.i. cerebrovascular accident) or metabolic (e.i., diabetes mellitus I); not comply with a minimum of 90% of the total frequency of activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3vnwnq	Effects of the application of educational technology for guidance of parturient companions	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2707	Effects of educational technology for guiding female followers in labor in a reference maternity hospital in Fortaleza-Ceará	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Maternidade Escola Assis Chateaubriand	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-3vnwnq	<NULL>	healthy volunteers; both genders; older than 18 years; chosen by the pregnant women to participate in delivery as companions.	volunteers with cognitive impairment that prevented them from understanding the orientations that were being addressed; be accompanied by pregnant women with fetal death; companions of women who presented obstetric complications that contraindicated the use of non-pharmacological methods of pain relief.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-2w83nh	Evaluation of success and complications of implants with different types of implant-prosthesis connections.	Recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2708	Evaluation of success and survival rates, marginal bone loss and complications of implants with different types of implant-prosthesis connections: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-2w83nh	<NULL>	"In order to be included in the sample, patients will need to present the following characteristics:
Present edentulism with an indication of installation of dental implant and posterior preparation of dental prosthesis or indication of extraction of a dental element by crack / fracture or root perforation with indication for installation of immediate dental implant and posterior confection of a dental prosthesis;
To present good general state of health, that allows the accomplishment of the dental implant surgery;
Availability of time and time to attend dental appointments in institutions."	"Patients with any of the following characteristics may not be included in the sample:
Patient with some systemic disease that prevents the accomplishment of the surgery for installation of dental implant;
Patients with a history of chemo / radiotherapy in the last 10 years or who use systemic medications that may interfere with bone repair (eg bisphosphonates).
Patients who do not have available hours of care in educational institutions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-3bf686	Effect of adhesive strategy and different photoactivation times of a universal adhesive system on the longevity of composite resin restorations in patients with dental lesions near the gingiva.	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2709	Effect of adhesive strategy and different photoactivation protocols of a universal adhesive system on the longevity of composite resin restorations in patients with non-carious cervical lesions [LCNC] . Double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3bf686	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-88ykxm	Evaluation of the safety of products for health by doctors dermatologist and gynecologist under normal conditions of use	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2710	Evaluation of the gynecological and dermatological capacity of health products under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-21	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-88ykxm	<NULL>	Women. Age: 18 to 65 years. Phototype: I to IV. Whole skin of the region. Occasional user of category products	"Cutaneous marks in the experimental area that interfere in the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scarring, increased hairiness, ephelides and nevus in large quantities, sunburns). Pregnant or nursing mothers. Participants with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream.Participants with a history of allergy to cosmetic products of the category tested. Recent gynecological surgeries. Corrections. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-87dkhg	Thigh muscle strengthening associated with a therapeutic electrical stimulation compared to an isolated thigh muscle strengthening in subjects with atraumatic patellar dislocation	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2711	Quadriceps strengthening associated with neuromuscular electrical stimulation versus quadriceps strengthening alone to the treatment of atraumatic patellar dislocation: A blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-87dkhg	<NULL>	"Inclusion criteria: 
Individuals aged between 16-40 years, of both sexes, with a history of at least one episode of atraumatic patellar dislocation requiring emergency care. The participants should present with apprehension to the lateralisation of the patella, pain to the palpation of medial retinaculum and J-sign to the flexion and extension of the knee."	"Exclusion criteria: 
Individuals who are using knee imobilisation, crutches and those with restricted knee range of movement that prevents the realisation of the exercises protocol during the recruitment period. 
Individuals with a history of traumatic patellar dislocation, previous surgical treatment for patellar dislocation, those with a history of other ligaments (ACL, PCL, LCL or MCL) or meniscal injuries and those with a history of previous surgery on the lower limbs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-74hk74	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2712	Evaluation of dental acceptability of product with appreciability for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-21	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-74hk74	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	"Active dermatoses (local and disseminated) that may interfere with the results of the study. Screening or nursing. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopy. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Use of the following topical systemic medicinal products: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of lack of adherence or unwillingness to adhere to the study protocol;
Professionals directly involved in the realization of this protocol and their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-6fgy76	Own Cartilage Cells Transplantation: validation of the therapy protocol for Cartilage Lesions	Recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2713	Autologous Chondrocyte Transplantation: validation of the therapy protocol for Joint Cartilage Lesions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-6fgy76	<NULL>	Male; age between 18 and 40 years; with or without anterior cruciate ligament (ACL) injury; lesion of the articular cartilage in the femur or patella; degrees 2 or 3 of the International Cartilage Repair Society (ICRS) classification; diameter greater than 2 cm; symptomatic; without improvement with conservative treatment based on physical therapy, weight loss and medications	Superficial chondral lesion (classification ICRS grade 1); Subchondral bone lesion (ICRS grade 4); Osteoarthritis (Kellgren-Lawrence rating greater than 1); Misalignment of the mechanical axis of the lower limb in the frontal plane; Multiple ligament lesions; Previous surgeries in the affected knee; Meniscal lesions not sutured; Systemic inflammatory diseases; Inability to adhere to the rehabilitation protocol; Functional limitations due to pain in the spine or hips; Claustrophobia; Metal implants that ensure the performance of magnetic resonance; Obesity (BMI greater than 30); Smoking; Gestation; Cognitive changes with inability to read, understand and sign the EHIC.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-6n573b	Effect of Infrared LEDs compared to Respiratory Therapy Maneuvers in the Treatment of Community Pneumonia	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2714	Comparison of Infrared LED with Respiratory Physiotherapy Maneuvers in the Treatment of Community-Acquired Pneumonia	<NULL>	2, non-randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-01	Centro Universitário de Itajubá	PÂMELA CAMILA PEREIRA	https://ensaiosclinicos.gov.br/rg/RBR-6n573b	<NULL>	Participants aged 55-85 years; with a clinical diagnosis of community-acquired pneumonia (Streptococcus pneumoniae); undergoing conventional respiratory physiotherapy treatment; on oxygen therapy up to 1 L/minO2 and on antibiotic therapy (azalides, cephalosporins, fluoroquinolones); both sexes	Patients diagnosed with fungal and viral pneumonia; with hospital-acquired pneumonia (those hospitalized for more than 2 days in the previous 90 days); institutionalized; overweight (Body Mass Index – BMI: above 29.9 kg/m2); who do not sign the Informed Consent Form; who do not belong to the stated age range; who have neoplasms and a history of photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:08
RBR-97sqsb	The Dry Needling in Elderly	Recruitment completed	Intervention	2019-06-05	<NULL>	<NULL>	2715	Benefits of Dry Needling in Muscle Performance of Elderly Active	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Famema	FAP	https://ensaiosclinicos.gov.br/rg/RBR-97sqsb	<NULL>	According to the Mini Mental State Examination (MMSE); the elderly; female; older than 60 years of age; are physically independent and present a cognitive state preserved according to their level of education; according to the International Physical Activity Questionnaire ( IPAQ - Short Version); besides presenting a latent trigger point in the evaluated musculature.	Do not perform the tests; do not present trigger points in the evaluated muscles; fear of needle; history of adverse reaction to needle insertion; carry out therapy with anticoagulants; present area or limb with lymphedema or after lymphotomy surgery,; have compromised immune system ( hepatitis, bacterial endocarditis and acute rheumatoid arthritis); incapacitating lesion that does not allow testing; recent fracture of the lower limb; use of orthoses and prostheses in the lower limb; uncorrected visual disturbances; neurological disorders; uncontrolled cardiac problems and have used DN in the last 2 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-3znpr6	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2716	Evaluation of the dental acceptability of the product for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-3znpr6	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	Active dermatoses (local and disseminated) that may interfere with the study results. Pregnant or nursing mothers. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopia.Portadores de inmunodeficiencias.Transplanted renal, cardiac or hepatic. Use of the following systemic topical medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the realization of this protocol and their relatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-4dnqys	Treatment of impaired muscles after cerebral effusion by voluntarily activated electric shocks	Recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2717	Effectiveness of the Brain Interface Associated Machine Functional Electrical Stimulation in Patients with Sequelae after AVE	<NULL>	1-2, n/a, open	1-2	<NULL>	<NULL>	<NULL>	2019-03-15	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4dnqys	<NULL>	Patients post stroke at 6 months to 2 years after the injury who present motor deficit in the upper limb.	Patients with metallic implants in the limb to be treated or local hyposensitivity or allodynia. Disapproved in the Mini-mental test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5yv2xr	Use of corticoid associated with local anesthetic in anesthesia technique for video-assisted shoulder surgery	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2718	Prolongation of sensory block with the combination of Dexamethasone and Levobupivacaine in the brachial plexus block for shoulder arthroscopy	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2017-01-01	Financiamento próprio.	Financiamento próprio.	https://ensaiosclinicos.gov.br/rg/RBR-5yv2xr	<NULL>	Adult patients; age between 18 and 65 years; physical status 1 and 2 of the American Society of Anesthesiology (ASA P1 and P2); body mass index (BMI) &lt;30 kg / m2; both sexes; submitted to shoulder arthroscopy for treatment of rotator cuff rupture.	Puncture site skin infection; coagulopathy; brachial plexus neuropathy; systemic use of corticosteroids; routine use of opioids; diabetes; severe lung disease; psychiatric illness; and intolerance to one or more study medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5r93wn	Comparison of the effect and toxicity between two options for the treatment of Mucosal Leishmaniasis: Miltefosin and Liposomal Anfotericin B	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	2719	Efficacy and safety of Miltefosin in comparison with Liposomal Anfotericin B for the treatment of Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2018-03-01	Centro de Pesquisa Rene Rachou, Fundação Oswaldo Cruz	Hospital Universitário Julio Muller	https://ensaiosclinicos.gov.br/rg/RBR-5r93wn	<NULL>	Both sexes; age greater than 18 years; mucosal impairment; parasitological confirmation of Leishmania infection by one or more of the following methods: parasitological examination (direct examination or culture), histopathology, immunohistochemistry or molecular test; consentiment form signed; availability for the schedule of the study	Women in reproductive age with positive (serum) pregnancy test at the time of screening; or lactating women; or women who can not or will not use contraception during and for up to 3 months after discontinuation of treatment; Carriers of HIV infection or other immunodebilitating condition; hepatic enzimes levels 3 times above the upper limit of normal, according to reference values; previous treatment for LM in the 6 months prior to study inclusion; previous treatment with leishmanicidal drugs indicated for the treatment of other diseases in the last six months prior to inclusion;use of medications that interfere with the therapeutic response or that cause interactions with drug of the study;  A history of hypersensitivity to the drugs being tested; renal, cardiac, hepatic or psychiatric disease that at the discretion of the investigator represents a contraindication to the use of some of the treatment alternatives included in this study; disseminated leishmaniasis concomitant with mucosal involvement; intravenous drug users or other chemical dependencies; Sjogren-Larson syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-4pcbcn	Comparison of satisfaction of patients with high pressure in front of the different tools of health education	Recruiting	Intervention	2019-06-06	<NULL>	<NULL>	2720	Comparison of satisfaction of hypertensive patientes in front of the different tools of health education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-30	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pcbcn	<NULL>	Clinical diagnosis of Arterial Hypertension; in follow-up there is a minimum of 1 year; capable of effective oral communication without help	Illiterates; hearing deficiency; visual impairment; cognitive alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-48sj6d	Laser therapy in chronic shoulder pain	Recruiting	Intervention	2019-06-06	<NULL>	<NULL>	2721	Different doses of laser in patients with chronic shoulder pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Universidade Federal de São Paulo - UNIFESP	Departamento de Ciências do Movimento Humano da universidade federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-48sj6d	<NULL>	Patients with shoulder pain lasting at least 6 weeks; with ages ranging from 18 to 70 years	Patients who have had a history of significant trauma or systemic inflammatory conditions such as rheumatoid arthritis or rheumatic polymyalgia; neurological disorders that affect cognitive behavior and pain perception; disorders in the shoulder region that make it impossible to perform the assessments or protocol proposed; previous surgical procedure; pregnancy or breastfeeding; anticoagulant therapy; diabetes mellitus; heart conditions; shoulder infections; and people with contraindications to laser therapy will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-3p69hy	Evaluation of the possibility of implementing the Brazilian Food Program to Protect the Heart in people without cardiovascular diseases	Recruitment completed	Intervention	2019-06-06	<NULL>	<NULL>	2722	Evaluation of the feasibility of the Brazilian Cardioprotective Nutritional Program in primary prevention	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-21	Hospital do Coração/ Associação do Sanatório Sírio	Hospital do Coração/ Associação do Sanatório Sírio	https://ensaiosclinicos.gov.br/rg/RBR-3p69hy	<NULL>	"Individuals aged higher or equal to 18 years of both sexes who have at least one of the following conditions
Body mass index&gt; 29.9 kg / m2
Blood triglyceride concentration higher or equal to 150 mg / dl
LDL-cholesterol blood concentration higher or equal to 130 mg / dl or higher or equal to 100 mg / dl for diabetic patients
HDL-cholesterol blood level &lt;40 mg / dl
Systolic blood pressure greater or equal than 140 mmHg or diastolic blood pressure greater or equal than 90 mmHg or under drug treatment for hypertension
Fasting blood glucose higher or equal to 100 mg / dl or diagnosis of diabetes"	"Previous cardiovascular event acute myocardial infarction, stroke, peripheral arterial disease
Psychiatric or neurocognitive condition that impedes understanding of the guidelines defined by the clinical judgment of the investigators
Life expectancy less than 6 months example: malignant metastatic neoplasia)
Pregnancy or lactation
Hepatic insufficiency with previous history of encephalopathy or anasarca;
Chronic renal failure
Organ transplantation
Wheelchair
Gastroplasty a year ago
Impossibility of oral feeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-84bk8p	Seizure prediction with 24 hours of antecedence by non-invasive method	Recruiting	Observational	2019-06-06	<NULL>	<NULL>	2723	Convultion prediction with up to 24 hours of antecedence by simple and non-invasive method	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-22	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-84bk8p	<NULL>	The criteria of inclusion are age between 12 and 65 years old, diagnosis of epilepsy suspected or confirmed, and absence of skin lesions on wrist.	The criteria of exclusion are individual hospitalized at the video-EEG monitoring unit for less than 48 hours, individual displaying disconfort with the use of the wristband or with skin reaction potencially attributed to the use of the wristband, time of good quality monitoring of vital signs less than 10 hours across a sleep or wake period, individual whose diagnosis of epilepsy has not been confirmed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-72tgny	Assessment of immediate and prolonged skin irritation and / or allergy.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2724	Assessment of Primary Dermal Irritability, Dermal Irritability and Dermal Sensitization (HRIPT).	<NULL>	1-2, single-arm-study, single-blind	1-2	<NULL>	<NULL>	<NULL>	2019-04-16	Medcin Instituto da Pele Ltda.	Medcin Instituto da Pele Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-72tgny	<NULL>	Age between 18 and 70 years; Phototypes I, II, III and IV as adapted Fitzpatrick scale Annex 1; Skin of the whole test region;	"Gestation or risk of gestation and / or lactation when women; Use of anti-inflammatory drugs 30 days and / or immunosuppressants for up to three months prior to selection; Immunosuppression by drugs or active diseases;
Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days prior to evaluation or during the study period; Forecast of sea baths, swimming pool or sauna during the study; Practice water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the start of the study; Aesthetic and / or dermatological treatment in the body within 03 weeks prior to selection; Scheduled vaccination during the study period or until 03 weeks prior to screening; History of sensitization and irritation to topical product; Active skin conditions (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or cosmetics during the study; Skin reactivity; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant clinical history or current evidence of alcohol or other drug abuse; Known or suspected intolerance of any ingredient in the study products test or comparative products; History of lack of adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study. Other conditions considered by the researcher as reasonable for disqualification of study participation. If Yes, it should be described in observation in the clinical file;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-89hr2h	Electromyographic evaluation of respiratory muscles in children born Prematurely during Exercise Test	Data analysis completed	Observational	2019-06-07	<NULL>	<NULL>	2725	Electromyographic evaluation of respiratory muscles in children born Prematurely during Exercise Test	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-05-10	universidade federal de são paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-89hr2h	<NULL>	"Children between 6 and 9 years old or friends / relatives of children born prematurely. The preterm group: birth weight less than 1500 grams and gestational age less than 37 weeks and with no gait / run difficulties.
Control group: children between 6 and 9 years old, relatives or friends of the children included in the study."	Respiratory disorders such as wheezing and/or respiratory distress in the 2 weeks prior; acute pulmonary disease diagnosed by a physician;neurological and/or cognitive impairment that prevented understanding of the test; gait dysfunction; fractures and lower limb surgery in the previous 6months; hemodynamic alterations at rest such as tachycardia and/or hypertension; and hospitalization in the previous 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-2ckx5s	Acupuncture Ear ins students from an Internacional University	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2726	Auriculotherapy in academics from an International University	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Diego da Silva Ferreira	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2ckx5s	<NULL>	Students who are regularly enrolled and active in the classroom graduation courses. Accept to participate in the research. 18 years or older. Availability of time for submission to auriculotherapy sessions. They obtained high scores of signs of anxiety, stress and depression on the EADS scale. Low index in the quality of life questionnaire.	Students who are performing other energy therapy. They make use of anxiolytics and antidepressants. Pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-2bqy9p	randomized clinical trial on actinic keratoses of the face	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	2727	randomized clinical trial of microneedling followed by 5-Fluorouracil 5% versus use of 5-Fluorouracil 5% or 0.5% isolated in actinic keratoses of the face	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-03-31	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2bqy9p	<NULL>	patients with actinic keratosis on face  with minimum age of eighteen years no history preliminary melanoma	renal transplanted patients in use of immunosuppressors history of previous melanoma with health change	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5nxqy2	Jabuticaba juice effects on blood glucose, insulin and antioxidants	Recruitment completed	Intervention	2019-06-07	<NULL>	<NULL>	2728	Jabuticaba (Plinia jaboticaba) juice processed at high isostatic pressure and glycemic, insulinemic and antioxidant response in a pilot clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-06-07	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5nxqy2	<NULL>	healthy men and women aged 18-40 years; BMI 18-25 kg/m2.	allergy; hypersensitivity or intolerance to any foods/food ingredients; smokers; having a diagnosis of diabetes mellitus; hypertension or TAG; reported medical history of cardiovascular disease, cancer, liver, kidney or bowel disease; vegetarian or vegan diet; taking dietary supplements or receiving any drug treatment; pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-7fh22d	Effects of exergame and resistance training on reaction time, functional fitness and quality of life in older adults	Recruitment completed	Intervention	2019-06-07	<NULL>	<NULL>	2729	Active videogame and resistance training in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-06	Universidade Federal de Santa Catarina	Centro de Deportos da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7fh22d	<NULL>	Individuals of both sexes (target sample = 36 subjects); aged 50 years or older; not participating in regular exercise programs in the last month; not participating in active videogames in the last 12 months; people without visual and hearing impairment, which may hinder the identification of colours, images and sounds.	Diagnosis of Alzheimer&apos;s disease; Parkinson&apos;s disease; disabling neurological diseases; psychiatric comorbidities; neurodegenerative diseases; severe cardiovascular or metabolic disease; orthopedic injury that makes it difficult or impossible to carry out the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-7qjcdd	START Trial: Randomized, controlled, open and parellel trial to evaluate the efficiency and safety of intra-articular infiltration of Autologous Bone Marrow Concentrate (BMC) or Mesenchymal Stem Cell (MSC) associated with Platelet Rich Plasma (PRP) in patients with primary knee osteoarthritis	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2730	Randomized, controlled, open and parellel trial to evaluate the efficiency and safety of intra-articular infiltration of Autologous Bone Marrow Concentrate (BMC) or Mesenchymal Stem Cell (MSC) associated with Platelet Rich Plasma (PRP) in patients with primary knee osteoarthritis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-01-18	Prevent Senior Private Operadora de Saúde LTDA	Prevent Senior Private Operadora de Saúde LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7qjcdd	<NULL>	"Adults with age in between 49 and 75 years old; Clinical and radiological diagnosis of primary knee osteoarthritis with lesion of mild to moderate intensity (II and III) based on the classification criteria of the American 
College of Rheumatology (Altman et al., 1986) with radiological confirmation following a Kellgren and Laurence scale (1957); History of knee edema, pain, stiffness, gait alteration and loss of movement due to the degenerative joint process; Availability of follow-up during the study period; Have provided written voluntary consent to participate in the study, confirmed by the signature of Informed Consent Form."	BMI greater than or equal to 35; Being a carrier of other joint diseases or joint trauma, autoimmune diseases or have been subjected to the use of disease modifying drugs or intra-articular medication in the last 6 months; Evidence of secondary osteoarthrosis or with a history of other diseases in the articulation study, such as fractures, neoplasms, primary hematological disease, autoimmune, rheumatologic, neurological disease; History of acute or chronic communicable diseases, including B hepatitis; History of bone or cartilaginous disorders; Diagnosis of type I or type II diabetes, poorly controlled; Diagnosis of Hip Arthrosis through alteration in the physical examination or report with radiographic changes in the hip of the same side or contralateral; Evidence of active infection or history of infection in the joint to be infiltrated in this study; Any disease that affects the contralateral lower limb, such as consequence of OA of the knee; Deviation of the axial axis varus of 10 degrees or 15 degrees in valgus or discrepancy greater than 2.5 cm diagnosed by panoramic radiographic examination of limbs lower; Comorbidity that the physician considers as a contraindication for the infiltration of autologous stem cells; Contraindication to aspiration of the bone marrow (severe coagulopathy, skin infection in the area of ??the posterior iliac crest); Chronic treatment with anticoagulant or immunosuppressive drugs, except AAS 100mg; Use of a systemic corticosteroid in the last 3 months; Use of nonsteroidal anti-inflammatory drug in the last 15 days; Change in the use of oral chondroprotection continued for less than 3 months; Previous surgery (at any time) of the affected knee or orthopedic surgery lower limbs in the last 12 months; Present renal and / or hepatic functions out of normality; Present values ??that are not normal in laboratory tests, according to reference values; Hypersensitivity to any investigational product; Other clinical conditions which may, according to medical criteria, discourage participation in the study; Pregnant or otherwise pregnant women who do not use methods contraceptives; Development of clinical conditions that compromise the response to questionnaire and that may influence the results of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-33s6x5	Effect of a mouthwash containing Cinnamomum zeylanicum Blume (Cinnamon) for treatment of oral candidiasis	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	2731	"Clinical evaluation of a mouthwash based on Cinnamomum zeylanicum Blume (Cinnamon) on
Candida species in patients with denture stomatitis"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-33s6x5	<NULL>	Individuals aged 40 to 70 years with oral candidiasis and who wore removable dentures.	Individuals who had undergone topical and/or systemic antimicrobial treatment or were sensitive to C. zeylanicum EO or nystatin were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-54bvbb	Effect of respiratory training on quality of life of patients with traumatic spinal cord injury: a randomized controlled trial.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2732	Effect of inspiratory muscular training on quality of life of patients with traumatic spinal cord injury: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-21	Universidade de Brasília-FCE	Universidade de Brasília-FCE	https://ensaiosclinicos.gov.br/rg/RBR-54bvbb	<NULL>	The male and female, with traumatic spinal cord injury, with complete injury  (ASIA A or B) between the C4 and T4 levels occurred for at least 6 months.	Patients in programming surgical, portators of cardiopatia or pneumoopatia, sleep with infecciosas agudas or com any descompensation clinical, sleep, patients have apresentable conditions of can impossibility the training muscular inspiratory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-5qkm8k	Effects of cooling on perception of pelvic muscles in women with urinary incontinence	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2733	Effects of cryotherapy on the proprioception of pelvic floor muscles in women with urinary incontinence: a randomized, blind, crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qkm8k	<NULL>	Accept participate in the research and sign the Free and Informed Consent Form; Be 35 or older; Have a complaint of Urinary Incontinence; Not having undergone physiotherapeutic treatment for Urinary Incontinence.	Being overweight; Have allergy to latex and / or ice; Being with a urinary or vaginal infection; Have pelvic organ prolapse greater than grade II; To present cognitive and neurological disorders, uncontrolled arterial hypertension or inability to perform the evaluation; Make use of hormone replacement therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-3qhwjj	Avaliação do tratamento com a luz e as lesões pré-malignas da face e do couro cabeludo comparando duas diferentes técnicas de iluminação.	Recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2734	Pain evaluation during photodynamic therapy of the field of cancerization of the face and scalp comparing two different lighting techniques: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-02	Universidade Julio Mesquita Filho	Fundação Hospital Amaral Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-3qhwjj	<NULL>	Sign the free and informed consent form (TCLE - Annex1);Age over 50, of both sexes; Holders of at least 3 bilateral QAs with clinical similarities between hemifaces / hairy hairs; No treatments in the last 3 months.	Women of gestational age not using contraceptives; History of skin photosensitization; Hypersensitivity to porphyrins; Photodermose; Any associated immunosuppressive conditions (eg, HIV, systemic disease, use of corticosteroids, kidney transplant recipients). Note: patients with multiple QA criteria on the face and simultaneously on the scalp, will only be included in the most compromised region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-9qm3x9	Influence of an educational video to improve Vaccination against human papillomavirus	Not yet recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2735	Effect of an educational video for adherence to Vaccination against human papillomavirus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qm3x9	<NULL>	"Schoolchildren: To be a female student, to be nine years old, to be in the fourth year of elementary education in public elementary schools of Sanitary District IV of the city of Recife-PE;
Adolescents: To be a female or male student between the ages of ten and 14, to be in one of the series comprised between the fifth and ninth years of public elementary schools in Sanitary District IV of the city of Recife-PE;
Parents: to be 18 years of age or older, to have a child of age in the vaccination age, to have a child enrolled in public elementary schools in Sanitary District IV of the city of Recife-PE.
In addition, inclusion criteria for schoolchildren and adolescents have not received any dose of the HPV vaccine and, for the parents, have had a child who has not been vaccinated against HPV in order to perform the evaluation of the practice for immunization, evidencing adherence to vaccination."	"Schoolchildren: to be away from school activities due to illness or suspension;
Adolescents: being away from school activities due to illness or suspension;
Parents: have some cognitive limitation that makes it impossible to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-9g4dwc	Evaluation of the efficacy and safety of a product for health.	Recruitment completed	Intervention	2019-06-08	<NULL>	<NULL>	2736	Evaluation of efficacy for cryolipolysis membrane	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-23	Ipclin - Pesquisa Clínica Integrada	VITA VERT INDUSTRIA E COMERCIO DE COSMETICOS LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9g4dwc	<NULL>	30 participants in total. age group from 18 to 65 years. female or male. in the study regions. phototypes I to IV (according to the Fitzpatrick classification). participants agreeing to follow the procedures and requirements of the study and participating in the Institution at the time and date determined for the evaluation. Have been clarified about the research (objective, methodology, duration, risks and expected benefits). Participants who have the capacity to consent to their participation. sign the Free and Informed Consent Form; (TCLE). Participants who agree not to use products of the same category during this survey. Participants who wish to participate in the study without financial gain. They will only be refunded for expenses like food. Participants who did not participate in similar studies for at least two months prior to the study. Participants who declared that there was no risk of pregnancy during the study period.	Diabetes. Skin diseases. vitiligo. psoriasis. lupus. atopic dermatitis. Skin marks in the experimental area that interfere with the evaluation of possible skin reactions. Active dermatoses (local and disseminated) that may interfere with the study results. Pregnant or nursing mothers. History of allergic reactions. irritation or intense discomfort sensations the product category tested. Participants with a history of allergy to the material used in the study. History of atopy. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Intense sun exposure or tanning session up to 15 days prior to the initial evaluation. Prediction of intense sun exposure or the tanning session during the study driving period. Forecast to take a bath, pool or sauna during the study. Use of the following topical systemic medicinal products: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Treatment with acid vitamin A and / or its derivatives oral or topical up to 01 month before the start of the study. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the implementation of this protocol and their families	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6ws3m6	Evaluation of the Efficacy and Safety of a product for health in burned skin.	Not yet recruiting	Intervention	2019-06-08	<NULL>	<NULL>	2737	Evaluation of a health product for the prevention of burns under normal conditions of use.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Ipclin - Pesquisa Clínica Integrada	Sterifarma Produtos Cirurgicos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6ws3m6	<NULL>	Age from 18 to 65 years. Gender: male or female. All phototypes. Skin integrity in the test area, selected by the dermatologist, except for possible grade I or II skin burn resulting from radiotherapy. Participants who have given their free and informed consent, are cooperative and aware of the necessity and duration of the controls, so that a perfect adherence to the protocol can be expected. Participants able to read and understand the documents delivered (information leaflet and consent form) and what is explained to them. Participants who agree not to apply any other cosmetic products on the face during the study period, except for the research product and usual hygiene products.	"Pregnancy or lactation;
Pregnancy or lactation. Skinmarks in the test region that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large numbers). Participant with skin problem, in particular: urticaria, edema, eczema, recurrent herpes, herpes zoster occurred in the last 3 months, polycythemia, common acne with onset of nodules or cysts, psoriasis, ichthyosis, lichen planus, lupus, hyperhidrosis. Active dermatoses (local or disseminated) that may interfere with the study results. History of allergic or irritant reactions to topical products: medicines, cosmetics or health correlates of the same category (or other category, but which the investigator considers relevant). History of intense discomfort sensations to topical products: medicines, cosmetics or health correlates of the same category (or other category, but which the researcher considers relevant). Be participating or have participated in another clinical study completed less than 14 days prior to the selection. Any previously unquoted condition which, in the opinion of the investigator, could jeopardize the evaluation of the study;
History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the realization of this protocol and their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-2ppp6w	Respiratory Muscle Training in the Postoperative Period of Myocardial Revascularization Surgery	Recruiting	Intervention	2017-11-27	<NULL>	<NULL>	2738	Implications of the Training with Volume Incentive Spirometry in the Postoperative Period of Myocardial Revascularization Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-2ppp6w	<NULL>	Individuals submitted to myocardial revascularization; both sexes; between 18 and 70 years.	Individuals who present postoperative complications that could delay hospital discharge, considering the average number of days of hospitalization (maximum 10 days); individuals unable to understand and follow the research procedures (follow the evaluation protocol before and after the research intervention).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4g2jw3	"Effects of physical activities to control chronic diseases
with blood analysis, work environment and physical inactivity in military police: clinical study"	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2739	"Effects of interventions to control chronic diseases
with biochemical, environmental-occupational and
sedentary behavior in military police: clinical study"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	Universidade São Judas Tadeu	Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-4g2jw3	<NULL>	To be a military police officer, volunteer, of units: operational and administrative; Male and female; Be in the condition of &quot;active&quot; service; Have at least one year of experience in the Units they serve; Sign the free and informed consent form (TCLE); Have a medical certificate to practice physical activity assessing their clinical state of health to perform interventions with military police.	Police officers working inside the State; Police officers who are already in the paid and retired reservation; Military officers under 25 and over 58; is unable to make interventions for clinical, administrative or judicial purposes within the period specified in the schedule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-667rhb	Evaluation of the efficacy of phenol use in the sensory pathways of the hip, guided by ultrasonography, for the relief of chronic pain in patients with advanced arthrosis	Recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2740	The effectiveness of US-guided phenol block of the articular sensory branches of the obturator and femoral nerves for the relief of chronic pain in advanced osteoarthritis of the hip - A prospective study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-667rhb	<NULL>	Individuals over 18 years of age; clinical and radiological diagnosis compatible with advanced hip osteoarthritis; pain greater than or equal to 4 on a numerical scale of 0 to 10 (where zero means absence of pain and 10 the most intense pain imagined); chronic pain (more than 3 months)	Cognitive impairment or psychiatric disease; infection; coagulopathy; previous hip surgery; local deformities; other potential causes of pain referred to the hip region but not related to femoroacetabular osteoarthrosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-9msccy	Impact of H1 Forel&apos;s field deep brain stimulation on Parkinson&apos;s disease gait disorders	Recruitment completed	Intervention	2019-06-10	<NULL>	<NULL>	2741	Clinical and electrophysiological analysis of forel&apos;s field h1 deep brain stimulation on motor symptoms, cognitive variables and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-03	Hospital Santa Marcelina	Hospital Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-9msccy	<NULL>	Patients diagnosed with Idiopathic Parkinson&apos;s disease according to the criteria of Queen Square Brain Bank; be over 35 years of age and less than 80 y-old; staging of Parkinson&apos;s Disease (Hoehn and Yahr scale), greater than 2 when evaluated in the absence of antiparkinsonian drugs effect; preserved clinical response to levodopa, the patient should present at least 30 percent reduction in the score of motor score the UPDRS scale; significant motor dysfunctions for 3 hours per day or more, despite the best drug treatment; persistent motor dysfunction for at least 1 month despite drug adjustment; patient&apos;s desire to receive deep brain stimulation as a therapeutic option in PD; adequate cognitive performance for the demand associated with the necessary care in the postoperative, with the DBS equipments, and in the recognition of adverse events; availability of the caregiver or family member, and of the patient himself, to come in frequent returns to ensure the best parameters of brain stimulation	Parkinsonism associated with other neurodegenerative diseases (multisystemic atrophy; dementia with Lewy bodies; corticobasal degeneration; frontotemporal dementia; spinocerebellar ataxia); vascular parkinsonism; parkinsonism associated with antidopaminergic drugs; normal pressure hydrocephalus; traumatic brain injury; previous surgical treatment for Parkinson&apos;s Disease (pallidotomy, thalamotomy, campotomy or deep brain stimulation); patients with uncompensated systemic pathology; Parkinson&apos;s disease associated psychosis; major depression according to DSM-IV criteria - American Psychiatric Association 2000; dementia associated with Parkinson&apos;s disease, according to the criteria of the Movement Disorders Society	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-2qfz6q	The role of anesthetics in breast surgery	Recruiting	Observational	2019-06-10	<NULL>	<NULL>	2742	Total venous anaesthesia versus balanced anaesthesia in breast surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Hospital Sírio-Libanês	Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-2qfz6q	<NULL>	Female patients between the ages of 18 and 75 undergoing radical mastectomy.	"Patients with previous diagnosis of psychiatric disease
Missing analogue visual scale (EVA) data, tool used for pain assessment
Patient with pain before the surgical procedure.
Patient who used the Patient Controlled Analgesia Pump (PCA) after surgery.
Patient who underwent anesthetic block during the surgical procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6vpxz6	Assessment of the safety and efficacy of a nasal spray product.	Not yet recruiting	Observational	2019-06-10	<NULL>	<NULL>	2743	Subjective evaluation of the clinical efficacy of a nasal spray.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Ipclin - Pesquisa Clínica Integrada	Master ind. e com. de produtos odontológicos e farmacêuticos ltda	https://ensaiosclinicos.gov.br/rg/RBR-6vpxz6	<NULL>	"Age: 18 to 65 years
Female and male. Full skin in the study region (nose). Phototypes I to IV. Participants who agree to adhere to the procedures and requirements of the study and to attend the Institution on the days and times determined for the evaluations. Participants who have the capacity to consent to their participation, signing the Informed Consent Term (TCLE). Participants who agree not to use products of the same category during the conduct of this research. Participants who have not participated in similar studies for at least 2 months prior to the study."	"Diseases or medications that may directly interfere with the study or endanger the health of the research participant, according to the physician responsible for including study participants.
Immunodeficiencies. Renal, cardiac or hepatic transplanted. Erythema solar in the study region due to intense sun exposure 1 month before the study. Current use of the following medicines: corticoids, antihistamines, immunosuppressants, retinoids, anti-inflammatories. Participants who refuse to participate in the study in question.
Any condition that could interfere with the evaluations according to the investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-55mwvb	Effects of different Cementitious materials on the longevity of Ceramic crowns - A clinical research	Recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2744	Effects of different Cementation strategies on clinical performance of Zirconia crowns-A randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2013-11-28	Voco do Brasil Ltda	Voco do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-55mwvb	<NULL>	Patients must be at least 18 years of age; good general health; at least 20 teeth present in the mouth; healthy gum tissue and use of two zirconia crowns in the anterior or posterior region; Where the maximum horizontal mobility is 1mm be accepted.	Patients who suffer from bruxism, poor oral hygiene and periodontal disease will be deleted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4twg7m	Exercise with ventilation in lung disease.	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2745	Physical training in pulmonary disease with ventilatory support	<NULL>	4, single-arm-study, single-blind	4	<NULL>	<NULL>	<NULL>	2019-08-01	Programa de Pós Graduação em Saude e Desenvolvimento da Região Centro-Oeste, UFMS	Hospital Universitario Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-4twg7m	<NULL>	"Will be included volunteers with at least 35 years of age;
COPD patients according to GOLD II, III and IV criteria;
Free of exacerbation for at least four weeks;
Who are not participating in any pulmonary rehabilitation program."	"Individuals who are unable to perform Cardiopulmonary exercise test on a cycloergometer; 
Are not fit from a cardiovascular and metabolic point of view;
use of beta-blockers; signs of ischemic coronary and / or peripheral disease; uncontrolled diabetes; hypo or hyperthyroidism;  rheumatic or neurological disease; asthma; cognitive deficit; hypercapnic chronic obstructive pulmonary disease, that is, carbon dioxide blood pressure above 50 mmHg in resting arterial blood gases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6fyzgd	Assessment of the benefits of MASQUELIER&apos;s® Original OPCs within a farmer population highly exposed to pesticides in South Brazil	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2746	Double-blind randomized clinical trial assessment of the benefits of MASQUELIER&apos;s Original OPCs within a farmer population highly exposed to pesticides in South Brazil	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-06-07	International Nutrition Company (INC Agency BV)	International Nutrition Company (INC Agency BV)	https://ensaiosclinicos.gov.br/rg/RBR-6fyzgd	<NULL>	It will be included individuals with current agrochemical exposure and with a history of exposure to agrochemicals as a labor activity for at least five years. The selection of farmers has the support of the Department of Health of the Municipality of Santo Amaro da Imperatriz. Another supporting agent will be the Jorge Duprat Figueiredo Foundation for Safety and Occupational Medicine (FUNDACENTRO).	(1) Any dietary supplements with potential effects on antioxidant and inflammatory status are prohibited from 4 weeks before inclusion into this study and during the study period; (2) Any other investigational product is prohibited from 4 weeks before inclusion into this study and during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4xhrsy	Effects of a combined exercise program during hemodialysis treatment in patients with Chronic Kidney Disease	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	2747	Effects of an aerobic exercise program during intradialytic treatment in patients with chronic kidney disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-05	Universidade Federal do Rio Grande do Sul - UFRGS	Hospital de Clínicas de Porto Alegre - HCPA / UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-4xhrsy	<NULL>	"Diagnosis of Chronic Kidney Disease more than six months.
Patients in hemodialysis for at least 3 months.
Patients in hemodialysis at the Nephrology Department of the Hospital de Clinicas de Porto Alegre or in the Instituto de Doenças Renais
Older than 18 years.
Sedentary.
Physical condition to perform exercises and tests proposed in this study.
Stability of the chronic kidney disease more than 30 days."	"Patients who do not perform all stages of the study.
Presence of acute myocardial infarction in the last 3 months.
An active inflammatory or infectious process.
Decompensated coronary artery disease.
Implantable kidney transplant candidate with live donor expected to undergo transplantation in the next 4 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-5k9v4p	The influence of the autonomic nervous system in postmenopausal women with Dry Eye Syndrome	Recruiting	Observational	2018-08-09	<NULL>	<NULL>	2748	Cardiac Autonomic Modulation in Postmenopausal Women with Dry Eye Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto de Cirurgia Ocular do Nordeste, ICONE	Instituto de Cirurgia Ocular do Nordeste, ICONE	https://ensaiosclinicos.gov.br/rg/RBR-5k9v4p	<NULL>	Post-menopause; dry eye	History of hysterectomy; cardiovascular disease, infarction, and arrhythmia; pregnancy; and current diagnosis of neoplasias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6347fv	Clinical trial for evaluation of the anti-plaque effect and gingival inflammation of a mouthwash containing chlorhexidine tetrapalmitate	Recruiting	Intervention	2019-06-11	<NULL>	<NULL>	2749	Development of mouthwash containing chlorhexidine tetrapalmitate and clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara	Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-6347fv	<NULL>	"To present a proven diagnosis of gingivitis;
Presence of plaque in 30% or more of the sites;
Presence of at least 5 teeth in each hemi-arch;
A negative history of antibiotic use in the last six months before the study;
A negative history of steroid or non-steroidal anti-inflammatory drugs in the last three months prior to or during the study."	"Received periodontal treatment in the last 12 months;
To present a systemic condition that interferes in the health-disease process;
Be pregnant or breastfeeding;
Be smoker;
Present allergy to chlorhexidine;
To present partial removable prosthesis or fixed prosthesis / maladaptive restorations; 
No attendance for sample withdrawal, form filling and periodontal evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-2nf6xx	Use of mobile message for adherence to hypertension therapy	Recruitment completed	Intervention	2019-06-11	<NULL>	<NULL>	2750	Mhealth intervention for adherence to antihypertensive treatment through mobile technology	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-23	Centro Universitário de Maringá - UniCesumar	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-2nf6xx	<NULL>	Being enrolled in the HiperDia system; making medical treatment for diabetes mellitus and  or hypertension; being user of the WhatsApp app	Under 18 years old; more than 90 years; not having diabetes mellitus; not have hipertension; do not use WhatsApp app	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-7pz64y	Use of Laser in the healing of teeth Removal of patients submitted to Dental extraction after Radiotherapy in the head and neck region	Data analysis completed	Intervention	2019-06-11	<NULL>	<NULL>	2751	Use of Photobiomodulation in the Alveolar Repair of patients submitted to Exodontia after Radiotherapy in the head and neck region a double blind and randomized clinical study	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-10-01	Thyago Morais Vicente da Silva	Hospital de Câncer de Pernambuco - HCP	https://ensaiosclinicos.gov.br/rg/RBR-7pz64y	<NULL>	Were over 18 years of age; had presence of teeth requiring simple extraction; had a history of radiotherapy in the head and neck with a minimum of 60Gy in the maxilla and/or mandible; over 3 months since the conclusion of radiotherapy in the head and neck.	Patients allergic to penicillin, individuals with systemic compromise that would contraindicate the surgical procedure, in addition to patients undergoing palliative treatment, without the indication of surgical intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-65qh7j	Effect of elastic tape on shoulder tendinitis	Recruiting	Intervention	2019-06-11	<NULL>	<NULL>	2752	Kinesio tape in the injuries of the rotating sleeve: clinical test randomizado double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-65qh7j	<NULL>	Rotator cuff lesion grades I and II in the Neer classification; both sexes; age from 18 to 70 years; have signed the informed consent form (TCLE); subacromial pain for at least three months; two of the three positive impact tests (Jobe, Hawkins and Neer).	History of shoulder dislocation and seizure test for positive displacement; intratendine calcifications of the rotator cuff; presence of a proximal humerus anterior fracture; previous surgery on the shoulder; clinical and imaging diagnosis of total rupture in the shoulder rotator cuff tendon; adhesive capsulitis of the shoulder; acronym type III classification of Bigliani on X-ray; use of corticosteroid infiltrations three months prior to the study; presence of rheumatic and neurological diseases; pregnancy; be performing some type of therapeutic intervention for the shoulder in some other service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-3j787t	Effect of vitamin D supplementation and resistance training on muscle, bone, and inflammatory parameters in maintenance hemodialysis patients	Recruitment completed	Intervention	2018-08-07	<NULL>	<NULL>	2753	Effect of vitamin D supplementation and resistance training on body composition, physical capacity, inflammatory parameters and bone mineral metabolism in maintenance hemodialysis patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Associação Prudentina de Educação e Cultura APEC	Faculdade de Ciências e Tecnologia UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3j787t	<NULL>	Individuals older than 18 years; with chronic kidney disease on hemodialysis for a period greater than or equal to three months in the Hospital of Presidente Prudente “Doutor Domingos Leonardo Cerávolo”, Presidente Prudente, São Paulo, Brazil; do not have contraindications to physical activity; and accept and sign the Informed Consent.	Individuals unable to understand the procedures performed; prior diagnosis of coronary artery disease; positive exercise test for cardiac ischemia; Patients who have suffered stroke; patients with cancer, liver failure, chronic infection or acute in activity;  uncontrolled hypertension (&gt; 160 mmHg systolic or &gt; 100 mmHg diastolic); with amputated limbs; those that received cholecalciferol supplementation in the last 6 months; use of medications that affect body composition, such as corticosteroids and antiretroviral therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-58c63h	Use of percutaneous electrostimulation in the sacral region in the treatment of children with urinary tract symptoms associated with functional constipation	Recruiting	Intervention	2019-06-12	<NULL>	<NULL>	2754	Transcutaneous Electrical Nerve Stimulation in Children with Bladder Bowel Dysfunction: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-31	Glicia Estevam de Abreu	Escola Bahiana de Medicina e Saúde Peública	https://ensaiosclinicos.gov.br/rg/RBR-58c63h	<NULL>	Children and adolescents aged 05 to 17 years with vesicoureteral dysfunction	"Patients and / or caregivers who give up participating in the study after being included.
Patients who do not perform all the exams established in the care protocol.
Later diagnosis of neurological and anatomical alterations of the gastrointestinal tract and inferior urinary tract. If signs of hidden spina bifida or any other neurological abnormalities are identified on the physical examination of the lumbosacral spine, patients will be referred for a specialist investigation.
Patients with any change in urine summary such as glycosuria or osmolarity disorder, such as in diabetic mellitus and insipidus."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-8kdrbz	Prototyping of a neuromuscular stimulator and transfer of technology for using during hospital stay in the context of Health Unic System of Federal District	Recruitment completed	Intervention	2016-06-21	<NULL>	<NULL>	2755	Prototyping of a neuromuscular stimulator and transfer of technology for using during hospital stay in the context of Health Unic System of Federal District	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-27	Secretaria de Estado de Saúde do Distrito Federal	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8kdrbz	<NULL>	"Patients with traumatic brain injury,
Age between 18 and 60 years;
Patients up to 24 hours of mechanical ventilation."	"Patients diagnosed with chronic diabetes mellitus;
Patients with previous neuromuscular diseases;
Patients with a history of alcohol abuse;
HIV;
Chronic renal failure;
Patients using neurotoxic medications and / or neuromuscular blockers;
Spinal cord injury;
Pregnancy;
Skin lesions in the region to be treated;
BMI&gt; 35;
Patients with of systemic diseases;
Unstable fractures in the lower limbs that prevent the application of NMES."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5fg9c8	Comparison Between Spinal Erector Spinal Muscle Plane Block with Spinal Anesthesia and Morphine Spinal Anesthesia for Reduction of Post Operative Pain in Inguinal Hernia surgeries	Recruitment completed	Intervention	2019-06-06	<NULL>	<NULL>	2756	Comparison Between the Locking Techniques of the Erector Spinal Muscle Plan with Spinal Anesthesia versus Isolated or Opioid Spinal Anesthesia for Analgesia in Inguinal Hernioplasties: a Randomized Clinical Trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-12-04	Universidade do Sul de Santa Catarina	Sianest Servicos Integrados de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-5fg9c8	<NULL>	Patients older than 18 years; of both gender; ASA I and II; who underwent open surgery of unilateral elective inguinal hernioplasty	Patients with other surgery associated with the procedure analyzed (concomitant correction of contralateral or umbilical hernia); patients with ASA greater than III; weight less than 60 or greater than 100 kilograms; history of allergy to any medication of the study; use of anticoagulants or other contraindications to neuraxial block; postoperative cognitive deficit that prevented the patient from understanding / responding to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-29r8nr	Comparison Between Erector Spinal Plane Blocking Techniques versus Epidural Block for Postoperative for pain treatment in Open bladder surgeries	Recruitment completed	Intervention	2019-03-26	<NULL>	<NULL>	2757	Comparison Between Erector Spinal Plane Blocking Techniques versus Epidural Block for Postoperative Analgesia in Open Cholecystectomies: A Randomized Clinical Trial.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-12-03	Universidade do Sul de Santa Catarina	Sianest Servicos Integrados de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-29r8nr	<NULL>	patients over 18 years of age; ASA class I and II; undergoing elective open cholecystectomy with Kocher incision	patients requiring indication of emergency / emergency cholecystectomy; need for intraoperative cholangiography; need for posterior biliary manipulation; ASA III or higher patients; history of allergy to any study medication; use of anticoagulants; use of anticonvulsants; and deficit postoperative cognitive impairment that prevented the patient from understanding / responding to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-2q2f7h	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical trial	Data analysis completed	Intervention	2019-06-13	<NULL>	<NULL>	2758	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical tria	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidad Nacional de Colombia	Clinica de Especialistas	https://ensaiosclinicos.gov.br/rg/RBR-2q2f7h	<NULL>	"Comprised patients admitted to the 
preoperative evaluation, during the period from January to April 30 2018. Inclusion 
criteria were: persons between 50 to 75 years, patients scheduled for replacement less than 2 
months after the procedure knee"	"Exclusion criteria were: people with intellectual cognitive 
impairment, programmed to a different arthroplasty or knee replacement and denial of the 
patient to participate in research surgical procedure people."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-3s37xr	The effect of caries lesion sealing on molar teeth of milk	Recruitment completed	Intervention	2019-06-13	<NULL>	<NULL>	2759	Effectiveness of sealing of caries lesions in the internal and external half in deciduous molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-15	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3s37xr	<NULL>	Healthy volunteers; age between 4 and 9 years; one or more deciduous teeth with carious lesion on the occlusal surface; opening of the lesion less than or equal to 3 mm in the enamel, without previous restoration.	Volunteers with inappropriate behavior for dental care; immunodepressed; with special needs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-3jbnpr	Physiotherapeutic approach to pain during sexual intercourse in women with pain in the pelvic region: comparison between two techniques.	Recruitment completed	Intervention	2019-06-13	<NULL>	<NULL>	2760	Physiotherapeutic approach of dyspareunia in women with chronic pelvic pain: comparison between two techniques. A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jbnpr	<NULL>	Women over 18 years of age and pre-menopausal, with complaints of superficial dyspareunia with hypertonia of the pelvic floor muscles confirmed on palpation examination and who were sexually active.	Women with deep dyspareunia, pregnant, with untreated vaginal infection, presence of genital prolapse greater or equal to grade III, with cognitive difficulty to answer the questionnaires or who had two consecutive faults or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5mcvt6	Mckenzie method and Core stabilization exercises in lumbar pain due to disc herniation	Recruiting	Intervention	2019-06-14	<NULL>	<NULL>	2761	Mckenzie Method and Core stabilization exercises in lumbar pain due to disc protrusion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5mcvt6	<NULL>	Patients of both genders with ages between 18 and 65 years who present low back pain due to PD; not performing any other kind of physiotherapeutic approach to low back pain at the time of the study; have signed the Free and Informed Consent Form; present complementary MRI scans or computed tomography with PD report and / or disc herniation.	Severe vertebral pathologies (fracture, tumors and inflammatory pathologies, such as ankylosing spondylitis); previous surgery in the lumbar region; severe cardiovascular and cardiorespiratory disease; pregnancy; non-attendance in three consecutive or intermittent visits; patient with some neurological disorder and who can not perform the proposed exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-3x8nxn	The effect of returning the patient to the Resting Ventilator after performing the Spontaneous Breathing Test during the respirator withdrawal process	Recruiting	Intervention	2019-06-14	<NULL>	<NULL>	2762	Efficacy of the Protocol of patient Reconnection to the Mechanical Ventilator after success in the Spontaneous Breathing Test for Ventilatory Weaning	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade da Região de Joinville - UNIVILLE	Universidade da Região de Joinville - UNIVILLE	https://ensaiosclinicos.gov.br/rg/RBR-3x8nxn	<NULL>	"Age equal to or greater than 18 years;
Patients intubated on mechanical ventilation for more than 12 hours;"	"Mechanical ventilation for more than 21 days;
Patients with Glasgow Scale &lt;8;
Patients with no indication of cardiopulmonary resuscitation or reintubation;
Formal indication of non-invasive ventilation after extubation due to hypercapnia during the spontaneous breathing test;
Patients with spindle trauma, neuromuscular diseases.
Failure to obtain the informed consent term or withdrawal of study participation at any time."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-9g7kvc	Phone calls follow-up in the care of cancer patients under ambulatorial anti-cancer therapy: randomized clinical test	Not yet recruiting	Intervention	2019-06-14	<NULL>	<NULL>	2763	Telenursing in the care of cancer patients under ambulatorial antineoplastic therapy: randomized clinical test	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidade Federal do Ceará	Ambulatório de Quimioterapia do Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9g7kvc	<NULL>	Patients with diagnose of solid cancers of gastrointestinal tract, breast and lungs, because these represent the majority of people assisted in the referred outpatient care; Patients who are in the first or second chemotherapy cycle; Patients whose age is superior to 18 years old; Patients who scored 15 in Glasgow Coma Scale.	Patients who reached scores inferior to 60%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5jwzw4	Use of mobile goniometry application	Data analysis completed	Intervention	2019-06-15	<NULL>	<NULL>	2764	Validation and reliability of a goniometry application for mobile device (ANDROID): GONIOAPP	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5jwzw4	<NULL>	Students of the physiotherapy course of the Lutheran University of Brazil Campus Torres; age above 18 years; have signed the Term of Free and Informed Consent (TCLE)	Missed on one of the evaluation days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-4w8tdb	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	Data analysis completed	Intervention	2019-06-17	<NULL>	<NULL>	2765	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal da Paraíba	Savoy	https://ensaiosclinicos.gov.br/rg/RBR-4w8tdb	<NULL>	Age of 10 to 16 years that accept to participate of the research (agreement of agreement) and with consent of the parents or responsible ones (TCLE); has at least one lesion of active white spot on the vestibular face.	orthodontic appliance users; have extensive caries lesions or tooth sensitivity; children who do not allow the clinical examination. Also excluded are children and adolescents who are not residents of the metropolitan area of João Pessoa or exposed to drinking water from wells or sources other than the city&apos;s supply network	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-9chxvg	A randomized clinical study using Mta for the treatment of canal on milk teeth	Recruiting	Intervention	2019-06-17	<NULL>	<NULL>	2766	Randomized clinical assay of use the Mta in Pulpar Therapy of deciduous teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Angelus Industria de Produtos Odontológicos S/A	"Universidade Estadual Paulista  ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-9chxvg	<NULL>	Healthy children;upper and lower incisors or deciduous lower molars with deep carious lesion reaching the root pulp;spontaneous and persistent pain, dark red bleeding of difficult control; maximum resorption up to 2/3 of the root;restorable tooth;pulp exposure with clinical evidence of necrotic pulp or irreversible pulpitis.	Upper and lower incisors or deciduous lower molars with internal resorption;fistula near the gingival margin;Pulmonary calcifications; pathological mobility;periapical bone rarefaction with evidence of continuity solution in the crypt of the permanent successor germ.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-8hz5v5	Effect of scalp acupuncture in patients with chronic stoke - randomized clinical trial	Recruiting	Intervention	2019-06-17	<NULL>	<NULL>	2767	Effect of scalp acupuncture on cortical electrical activity in patients with stroke - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-25	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8hz5v5	<NULL>	Both genders; age above 30 years; sepsis of spastic hemiparesis; degree of moderate motor impairment as assessed by the Fulg Meyer scale; perform computed tomography to determine the area of the injury and clinical diagnosis; good cognitive ability; injury time over 3 months; sensory impairment assessed by the Fulg Meyer scale.	Hemiparesis due to another disease; cognitive impairment; neoplastic disease; bilateral motor and sensory sequel; hemorrhagic stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-9p4kst	How physical training is able to improve chest pain in patients without coronary disease	Data analysis completed	Intervention	2019-06-17	<NULL>	<NULL>	2768	Study of the mechanisms involved in the beneficial effects of aerobic physical training in patients with coronary microvascular dysfunction	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2012-04-02	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-9p4kst	<NULL>	"Patients with a diagnosis of coronary microvascular angina.
Patients of both genders, aged between 18 and 80 years."	"Precordial pain whose clinical features suggest non-ischemic origin;
Presence of obstructive lesions in coronary arteries that irrigate the ischemic area;
Physical limitation to aerobic exercise on treadmill;
Contraindication to the practice of moderate intensity aerobic physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-25pk92	Patient satisfaction and evaluation of the material to prepare the final smile test in aesthetic ceramic restorations.	Recruiting	Intervention	2019-06-17	<NULL>	<NULL>	2769	Mock-up evaluation for aesthetic oral rehabilitation: guide design and patient satisfaction	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-06	ABO-Goiás	ABO-Goiás	https://ensaiosclinicos.gov.br/rg/RBR-25pk92	<NULL>	Participants with a minimum age of 20 years; Participants of both genders; Participants receiving treatment with ceramic veneers in at least 10 teeth; participants who have teeth aligned and well positioned; participants who do not need major dental wear.	Participants with very vestibularized teeth, due to the impossibility of performing the mock-up without adequate prior adjustments with wear; participants who would receive some ceramic crown beyond the facets in the 6 anterior teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5c8f9m	Movement and sensibility, financial condition and welfare state of person after suffering from stroke	Data analysis completed	Intervention	2019-06-18	<NULL>	<NULL>	2770	Sensory-motor profile, socio-economic level and quality of life after Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-05	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5c8f9m	<NULL>	Individuals should authorize the procedures by signing the Free and Informed Consent Form, in addition to presenting the sequelae of stroke for at least six months.	The individuals with cognitive deficit and motor impairment that prevented the understanding and accomplishment of the evaluation were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-98r97j	Clinical investigation in deciduous teeth using Bulk Fill flow resin.	Recruitment completed	Intervention	2017-06-12	<NULL>	<NULL>	2771	Randomized double blind clinical trial using Bulk Fill flow resin in deciduous teeth by minimally invasive technique: three years of follow-up.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-98r97j	<NULL>	Healthy volunteer children; Both genders; Duly enrolled in municipal or state schools; With an acceptable oral hygiene level; With a minimum of 6 years and a maximum of 9 years.	Children who do not accept oral examination or restoration; Those that are missing on the scheduled restoration day; Those whose managers do not sign the Free and Informed Consent Form; Teeth with very deep carious lesions; Fistulated teeth; With such spontaneous pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-96mz5c	Therapeutic toys in schoolchildren: reference values in plethysmography	Recruitment completed	Observational	2019-06-18	<NULL>	<NULL>	2772	Reference values of parameters Pletismography and analysis of repercussion of institutional therapeutic toys in schools	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-26	Universidade do estado de Santa Catarina	unicamp	https://ensaiosclinicos.gov.br/rg/RBR-96mz5c	<NULL>	Absence of any history of congenital; cardiorespiratory; musculoskeletal; rheumatic and neurological disease,; as well as auditory and visual deficits; Absence of history of preterm birth; low birth weight and / or need for invasive mechanical ventilation in the neonatal period; Absence of acute respiratory disease on the day of the test;Satisfaction assessment by the questionnaire on asthma and allergies in childhood (International Study and Allergies in Childhood - ISAAC);Adequacy in the delivery of the informed consent term (TCLE) by the person responsible and the consent term for the minor.	"Inability to perform adequately any of the proposed evaluation procedures; modified pulmonary function test with values of forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) below 80% predicted by Polgar and Weng (1979) and FEV1 / FVC ratio less than 70% predicted.
Claustrophobia on entering the plethysmographic booth."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-7m2rmr	Stereotactic ablation of Hypothalamic hamartomas for seizure treatment	Recruitment completed	Intervention	2019-06-18	<NULL>	<NULL>	2773	Stereotactic ablation of Hypothalamic hamartomas for seizure treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m2rmr	<NULL>	Age between 13 and 50 years old, hypothalamic hamartoma identified on magnetic ressonance imaging and presence of refractory gelastic seizures	Alcohol Abuse, medication, or dependence on illicit substances in the Last 12 Months, clinically relevant lesions (other tumors than hypothalamic hamartoma, for example) in preoperative magnetic resonance imaging, patients undergoing chemotherapy for treatment of malignant tumors or who require chronic oral or intravenous treatment with immunosuppressants or steroids, patients unable to comply with schedule of study visits and timetable, lactating patients or with positive pregnancy test, other medical conditions that require probable hospitalization during the study, cronic infection, to have any metallic implant in the brain and current participation in another study of device investigation or drugs testing or surgeries of any nature.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-89tyds	Evaluation of Effects on Pain through the Use of Lidocaine Adhesive after Cesarean	Not yet recruiting	Intervention	2019-06-19	<NULL>	<NULL>	2774	Evaluation of the Analgesic Effects of 5% Lidocaine Adhesive in Post-operative Cesarean Section: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Instituto de Saúde Elpídio de Almeida - ISEA	https://ensaiosclinicos.gov.br/rg/RBR-89tyds	<NULL>	Age equal or superior to 18 years; Being submitted to cesarean section under spinal anesthesia; Classification of the American Society of Anesthesiologists 1 or 2.	Patients with a history of intolerance or chronic use of opioids or other medications proposed in the anesthetic procedure; Patients requiring tracheal intubation or supraglottic device during cesarean section; Patients who need to perform other surgical procedures concomitantly; Alcohol or drug addicts; Use of analgesics, opioids or not, within 24 hours prior to the procedure; Patients who report chronic pain in a previous cesarean operative wound; Inability to provide informed consent and low easily identifiable cognition; Patients with contraindication to neuroaxis blockade.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-9xrv64	Intervention to improve tracking for people with HIV	Recruitment completed	Intervention	2019-06-20	<NULL>	<NULL>	2775	Intervention to improve tracking in ambulatory care services for people with HIV	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Departamento de Medicina Preventiva da FMUSP	Programa Estadual de DST/AIDS	https://ensaiosclinicos.gov.br/rg/RBR-9xrv64	<NULL>	Outpatient care services for people with HIV; belonging to the health regions of Campinas, Osasco and São José do Rio Preto; CD4 and viral load test takers.	Outpatient services that do not care for people with HIV; outpatient services for people with HIV who are not requesting CD4 and Viral Loading.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-5z8mkc	The use of Super Glue® in perineal laceration in birth	Recruitment completed	Intervention	2019-06-21	<NULL>	<NULL>	2776	The use of ethyl cyanoacrylate glue (Super Glue®) to repair first degree perineal laceration in birth	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2016-05-04	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Hospital e Maternidade Municipal Amador Aguiar	https://ensaiosclinicos.gov.br/rg/RBR-5z8mkc	<NULL>	Non risk normal delivery 1st degree laceration that needs perineal repair.	Birth complications and others perineal conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-85d58z	Effects of exercise and athletic tape on the arm of stroke patients	Recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2777	Effects of Kinesiotherapy and Elastic Functional Banding on the upper limb of spastic hemiparetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-03	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-85d58z	<NULL>	Volunteers with active wrist movements; spasticity grades 1 to 3 in the flexor muscles of wrist and fingers 2nd Modified Ashworth Scale; medical indication for physiotherapeutic care; injury for more than 6 months; adequate comprehension skills and communication skills.	Volunteers who present with allergic processes to functional elastic bandage; degrees 0 or 4 of spasticity according to the Modified Ashworth Scale; Wernicke&apos;s aphasia; other associated neurological pathologies; history of lesions that preclude joint movements on the side of the paresis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-44np8k	The effects of Geotherapy on Heartburn and Reflux Symptoms: pilot clinical trial	Recruitment completed	Intervention	2019-06-21	<NULL>	<NULL>	2778	The Effects of Geotherapy on the symtoms of Gastroesophageal Reflux disease: pilot clinical trial	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2018-10-07	Unisul	Unisul	https://ensaiosclinicos.gov.br/rg/RBR-44np8k	<NULL>	"Be at least 21 years of age;
Have a diagnosis of gastroesophageal reflux;
Be willing to attend the sessions of the research protocol in full;
Know how to read and write;"	"Present lesions on the skin in the region where the clay poultice will be applied;
Patients undergoing recent gastroesophageal surgery (time less than 30 days), who present a surgical incision in the healing process and still under the effect of post-surgical drug therapy (analgesics, antipyretic and antiemetic);
Use of topical medications in the region that compromise the application of epigastric cataplasm."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-575f79	Dental canal infections and Impact on Quality of Life	Recruitment completed	Observational	2019-06-21	<NULL>	<NULL>	2779	Apical Periodontitis and Impact on Quality of Life	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-26	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-575f79	<NULL>	Patients older than 18 years with clinical and radiographic evidence of apical periodontitis (chronic periapical changes) requiring endodontic treatment will be included in the present study sample. Those individuals who have teeth that do not respond to the sensitivity test; have not received previous endodontic treatment and present clinical and radiographic evidence of apical periodontitis will be included.	Pregnant women, teeth with previous endodontic treatment; and number of teeth present of less than 10 will be excluded. Patients who use chronic steroid anti-inflammatory drugs will also be excluded. Patients with severe systemic complications or who use medication that requires medical consultation prior to dental treatment. Patients with communication difficulties noted during the interview. Patients who have teeth with extensive loss of dental structure that require prosthetic rehabilitation for rehabilitation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-82f4tb	Motor Imagery and Rehabilitation in Temporomandibular disorders	Not yet recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2780	Graded Motor Imagery as an aditional tool for rehabilitation in Temporomandibular disorders	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-82f4tb	<NULL>	Individuals diagnosed with TMD, according to the RDC / TMD classification; who present pain as one of the main symptoms of the dysfunction; for at least 3 months and with intensity of at least 3 according to the Visual Analogue Scale (VAS).	History of previous central pathologies and / or cognitive alterations that make it impossible the comprehension of the methods that will be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-3h4csb	The effect of music therapy in the reduction of fatigue of the patients undergoing bone marrow transplantation	Recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2781	The effect of music therapy in the reduction of fatigue of the patients undergoing hematopoietic stem cells transplantation autologous	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2018-05-02	Hospital Erasto Gaertner	Carlos Antonio Dóro	https://ensaiosclinicos.gov.br/rg/RBR-3h4csb	<NULL>	Patients submitted to autologous hematopoietic stem cell transplantation over the age of 18 years.	All the people that not relize transplant autologous	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-8xbqk5	The Effect of Diet on the Renal Function of Renal Transplant Patients: Nutritional Status and Quality of Life	Not yet recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2782	Effect of Nutritional Therapy on Renal Function of Individuals Undergoing Renal Transplantation: Evaluation of Nutritional Status and Quality of Life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8xbqk5	<NULL>	Individual volunteers, submitted to Kidney Transplantation at University Hospital Onofre Lopes (HUOL), of both genders, aged 18 years or over.	Individuals with a baseline diagnosis of Segmental and Focal Glomerulonephritis (GESF); performing multiple organ transplantation; history of recurrent transplantation due to chronic rejection; illiterate individuals who do not have a literate companion; individuals who did not complete all the steps foreseen in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-6vr58b	Pulp repair response of primary teeth after the use of a new bandage	Recruiting	Intervention	2019-06-24	<NULL>	<NULL>	2783	Pulp repair response after the use of dental/pulp biostimulation bandaging in primary teeth: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-6vr58b	<NULL>	The criteria of inclusion of the sample will include children between 5 and 9 years of age (Marques et al., 2014; Fernandes et al., 2015, Lourenço Neto et al., 2015, Lourenço Neto et al., 2016; Yildirin et al. , 2016; Juneja, Kulkarni 2017) of both genders, which are cooperative, present at least one deciduous molar with a lesion of deep caries that reaches the pulp, absence of fistula or abscess, absence of furcation and periapical injury, vital pulp with no history of pain, radiographic absence of internal and external resorption of the root, presence of at least two thirds of the radicular length proven in the radiograph and tooth with restorative possibility. The final selection for inclusion in the study will be performed at the clinical stage, where it will be verified whether hemostasis will be adequately achieved within 5 minutes after amputation of the coronal pulp (Marques et al., 2014; Fernandes et al., 2015; Lourenço Neto et al. (2006).	The exclusion criteria will be presence of systemic pathologies, history of allergic reaction to the latex of absolute isolation or local anesthetic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-5kwwxv	Effect of Laser therapy in dental trauma	Recruiting	Intervention	2019-06-24	<NULL>	<NULL>	2784	Effect of Photobiomodulation therapy in dental trauma of permanent anterior teeth,randomized blind and controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-10-24	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5kwwxv	<NULL>	Patients with a history of dental trauma; extrusive luxation; intrusive; lateral;avulsion; in anterior permanent teeth, with a maximum age of 35 years.	Deciduous teeth; permanent posterior teeth and canines; enamel fracture; enamel fracture with or without pulp exposure; coronary-root fracture root fracture;concussion/subluxation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-3y78y4	Trial to Compare the Efficacy of elástic bandage 3M Coban™ 2 Lite against the Unna Boot in Patients with Leg Ulcers	Recruiting	Intervention	2019-06-25	<NULL>	<NULL>	2785	Multicenter, Open, Randomized, Controlled Trial to Compare the Efficacy of 3M™ Coban™ 2 Lite Two Layer Compression System to the Unna Boot in Patients with Venous Leg Ulcers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-26	Escola de Enfermagem da Universidade Federal de MInas Gerais	Escola de Enfermagem da Universidade Federal de MInas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3y78y4	<NULL>	"Male or female, aged 18 years or older; Ability to walk, either independently or with the aid of a walker; Active venous leg ulceration. If multiple eligible ulcers are present in the same leg, a single ulcer of the study leg that is up 2cm apart from any other ulcer should be selected. If eligible ulcers are on both legs, the investigator will determine which ulcer to choose as the indexed ulcer; Ulcer size between 5 cm2 and 200 cm2; Ulcer present for major 4 weeks and minor 52 weeks at the time of the screening visit; Visible edema in the leg with the selected ulcer; ABI up 0.8 and minor 1.3. ABI assessment performed within the 3 months prior to enrolment is acceptable; Provided written informed consent, including permission to take photographs of the study leg, including the wound; Ability to understand the study procedures and to complete the questionnaires; Women of childbearing potential should be sexually inactive or should use one of the following acceptable contraceptive methods (and continue to use it for at least 30 days after the end of the study; Stable hormonal contraceptive for at least 3 months prior to the study;Barrier method (preservative or diaphragm) with spermicide for at least 7 days prior to the screening visit; IUD placed at least 3 months prior to the study.
Women that are not of childbearing potential should be either surgically sterile (surgical bilateral tubal ligation at least 6 months prior to the study, hysterectomy or bilateral oophorectomy at least 3 months prior to the study), or be post-menopausal for over 2 years."	"Severe arterial occlusive disease; Decompensated heart failure (New York Heart Association {NYHA} Class IV); Severe deep vein thrombosis (phlegmasia cerulea dolens) and other conditions contraindicated according to established guidelines and local procedures; Known hypersensitivity to any of the component materials, including isocyanates and synthetic rubber adhesives; Suspected clinical infection of the ulcer or any other systemic infection (requiring antibiotics); Planned or expected surgery for the ulcer during the 12 weeks following inclusion; Hospital stay planned for the 12 weeks following inclusion; Suspected or confirmed cancerous ulceration; Participation in any other prospective study interfering with this study; Any medical condition, which according to investigator’s clinical judgement, disqualifies the subject from enrollment into the study. Diabetic subjects are eligible if they are considered clinically under control or well-controlled; Autoimmune disease with use of systemic corticosteroids for more than 1 month (patients with auto-immune disease without use of systemic corticosteroids can be included). History of noncompliance to therapies; Severe impairment of the lymphatic system with severe deformation of the leg; Cardiomyopathy - diagnosis at screening; Dialytic chronic renal failure; Pregnancy;
Undergoing radiotherapy and chemotherapy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-278yfh	Effects of Aerobic Exercise Combined with Strength, done in varied ways, in patients with HIV who have used anti-disease drugs for more than one year and attended at a university hospital: a randomized clinical trial	Recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2786	Effects of a Periodized Combined Exercise Program on HAART patients for more than one year and attended at a university hospital: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-24	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-278yfh	<NULL>	Being a patient infected with HIV and using HAART for more than a year in the Infectious and Parasitic Diseases department of a University Hospital. Be between 18 and 60 years old. Good health condition for the practice of the proposed physical exercises. Being without physical activity or physical exercise for at least six months. Three-times-a-week trip availability for training location. These criteria will be verified by the physicians proposing this research (M Mário León Silva-Vergara and Fernando de Freitas Neves) during routine care.	Participant who presents any clinical complications throughout the intervention. Participant that presents some limitation that could compromise their physical integrity throughout the intervention with physical exercise. Have a diagnosis of opportunistic diseases in the last two years. Have a diagnosis of liver disease and / or nephropathy and / or neuropathy. Have a history of orthopedic surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-775d8m	Effects of using a Cell Phone Application while quitting smoking and satisfying participants of an existing Program	Not yet recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2787	Effect of the use of a mobile application on smoking cessation and satisfaction of participants in a Specialized Program	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-06-18	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-775d8m	<NULL>	Smoking patients; in the age group between 25 and 70 years.	Patients with severe psychic comorbidities;illiterate; who are not available to attend face-to-face meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-35qvjy	Evaluation of the Function of the Lungs in Patients with Pulmonary Injury in the Process of Withdrawal of the Mechanical Respirator	Recruitment completed	Observational	2019-06-26	<NULL>	<NULL>	2788	Evaluation of Pulmonary Mechanics of Patients with ARDS in Weaning Process from Mechanical Ventilation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-03	Iuri Christmann Wawrzeniak	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-35qvjy	<NULL>	Patients diagnosed with ARDS defined by the Berlin criteria for mechanical ventilation and defined by the care team beginning the weaning process of mechanical ventilation	Use of Cardiac Pacemaker;Injury in the thoracic cavity that makes impossible the placement of the electrodes of the tomograph of electrical impedance;Impossibility to perform the examination for reasons that may impair the patient&apos;s progress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-32gwpm	Effects of physical training and psychological training on performance, physiology and physical and psychological health of elite athletes	Recruitment completed	Intervention	2019-06-26	<NULL>	<NULL>	2789	Effects of physical training and psychological training on performance, physiology and physical and psychological health of elite athletes	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-32gwpm	<NULL>	Federated athlete; to be part of the same volleyball team, to be training and competing regularly; to have no injury or any health problem that could interfere with the result at the beginning of the experiments; to have a regular menstrual cycle.	Absence in training greater than 50%; Absence in interventions greater than 50%; lesion; health problem.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-4frcs6	The use of clobazam and clonazepam in conjunction with other antiepileptics in the treatment of focal epilepsies: analysis of their efficacy and adverse effects	Recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2790	The use of clobazam vs clonazepam as adjuvants in the treatment of focal epilepsy: effectiveness and adverse effects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4frcs6	<NULL>	"Diagnosis of focal epilepsy according to ILAE classification;
Focal epilepsy with at least 1 epileptic seizure every 2 months, in current use of monotherapy or polytherapy;
Age above 18 years;
Regularity and attendance at scheduled appointments."	"Comorbidities such as severe kidney or liver disease that prevent the use of therapy proposed by the study;
Use one of two study drugs, namely clobazam or clonazepam."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-56yk9m	Effects of a manual therapy technique on the stress of workers in the garment industry	Recruitment completed	Intervention	2019-06-27	<NULL>	<NULL>	2791	Acute effects of limbic touch on stress experienced by workers in the garment industry	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-07	Centro Universitário de Formiga	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-56yk9m	<NULL>	The inclusion criteria were confection workers of the city of Candeias female aged between 20 and 50 years of any educational level with a daily workload of eight hours who agreed to participate voluntarily in the research and who have not used any type of medication in the last month except contraception.	The criteria for non-inclusion were confection workers who were pregnant or breastfeeding who were using or who used any non-contraceptive medication in the last month who did not achieve a minimum score of 13 points in the Mental State Mini Examination ( MMSE) if they are illiterate or 19 points are read. The exclusion criteria were those who did not feel well during the technique and those who for any reason wished to withdraw from the research regardless of the phase of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-4ytbnk	The role of surgical removal of the adrenal gland in improving heart and blood vessel disease in patients with adrenal gland nodule and increased secretion of the hormone cortisol	Recruiting	Intervention	2019-06-27	<NULL>	<NULL>	2792	Cardiovascular features in patients with Adrenal Incidentalomas associated or not with Possible Autonomous Cortisol Secretion or with Autonomous Cortisol Secretion	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Incor - Instituto do Coração do Hospital das Clínicas da FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-4ytbnk	<NULL>	All patients diagnosed with adrenal incidentaloma and characteristics suggestive of benignity in CT and/or MRI of the abdomen (homogeneous image, density &lt;10UH pre-contrast, absolute washout&gt;60%). Patients who meet these criteria will be invited to participate in the study, involving surgical treatment (laparoscopic adrenalectomy) of their adrenal incidentalomas and/or medication of their comorbidities. Patients with bilateral lesions will undergo adrenalectomy of the larger lesion	Patients with adrenal incidentaloma and diagnosis of pheochromocytoma, primary hyperaldosteronism, Cushing&apos;s syndrome overt, adrenal carcinoma or malignancies including extra adrenal metastases; high adrenocorticotropic hormone concentration; history of alcoholism; administration of drugs that may influence cortisol metabolism, dexamethasone or cortisol secretion; patients undergoing previous open abdominal surgery; chronic renal insufficiency or any contraindication for surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-3yg34r	Study of the use of drugs used for dyslipidemia by the patients of the Pharmaceutical Care Service of the 4th Regional of Irati-PR and evaluation of service satisfaction	Data analysis completed	Intervention	2019-06-27	<NULL>	<NULL>	2793	Study of pharmacotherapeutic from the Clinical Protocol and Therapeutic Guidelines (PCDT / MS) of dyslipidemia applied to the Pharmaceutical Care Service of the 4th Regional of Irati-PR and evaluation of service satisfaction: A pharmacoepidemiological approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3yg34r	<NULL>	Patients diagnosed with dyslipidemia; using drugs from the Specialized Component of Pharmacy Assistance for dyslipidemia; over 18 years old; polymedicated; with more than 3 comorbidities.	Pregnant women; under 18; alcoholics; psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5xgjwm	Effect of Maternal Supplementation with Vitamin A, offered at different intervals, on vitamin A concentrations in breast milk and on the nutritional status of the mother and baby	Data analysis completed	Intervention	2019-07-02	<NULL>	<NULL>	2794	Impact of Maternal Supplementation with Double Megadose of Vitamin A administered at different intervals on the composition of the mother&apos;s milk and nutritional status of the mother-child binomial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal de Pernambuco	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5xgjwm	<NULL>	Age between 18 and 40 years. Low obstetric risk	Diabetes. Hypertension. Neoplasms. Diseases of the gastrointestinal tract. Liver diseases. Cardiovascular diseases. Infectious diseases. Mental disorder. Preterm birth, Twin pregnancy. Congenital malformations. Cerebral palsy. Supplementation with vitamin A during gestation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9yd86q	Evaluation of the base of the nose after orthognathic surgery: comparison of two types of Nasal Suture	Recruitment completed	Intervention	2019-07-02	<NULL>	<NULL>	2795	Assessment of alar base after orthognathic surgery: comparison of two types of Nasal Plication	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9yd86q	<NULL>	Patients submitted to orthognathic surgery; with bilateral vestibulomaxillary access; osteotomy le fort I; submitted to internal or external nasal plication.	Patients with cleft lip and / or palate, history of facial trauma, undergo rhinoplasty surgery after orthognathic surgery and before final clinical evaluation; presented dehiscence in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-69cyr2	Auriculotherapy in sleep disorders in patients with rheumatoid Arthritis.	Recruitment completed	Intervention	2019-07-04	<NULL>	<NULL>	2796	Invasive auricular acupuncture in sleep disorder in patients with rheumatoid Arthritis: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-69cyr2	<NULL>	Diagnosis of Rheumatoid Arthritis; age greater than or equal to 18 to 100 years; difficulties related to sleep: starting and / or maintaining sleep and also the presence of non-sleepy sleep for at least 1 month.	Cutaneous lesions in the auricular pavilion that prevent the placement of atrial acupuncture points; amputation of the auricular pavilion; previous otoplasty; suspected or confirmed pregnancy; phobia by needles; previous atrial acupuncture; deficits in vision, hearing or cognitive impairment that prevent the proposed evaluations from being performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-77z6q8	tDCS over the dorsolateral prefrontal cortex improves pain, anxiety and functionality in primary dysmenorrhea: a randomized sham-controlled trial.	Recruitment completed	Intervention	2019-07-04	<NULL>	<NULL>	2797	Transcranial direct current stimulation and it´s therapeutc potentiality in diferent populations.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-77z6q8	<NULL>	Aged from 18 to 40 years; regular menstrual cycle from 28 to 32 days; without breastfeeding; not history of brain surgery; not tumor hystory; not history of chronicle genitourinary infectious; without history of alcohol or drug abuse.	Mean pain score of at least 3 on the Numeric Rating Scale (NRS) during the menstrual cycle preceding the evaluation; patients presenting history of dizziness or epileptic disease; pregnancy; metal implants in the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-8nqywt	Use of music in pain relief during laser retinal photocoagulation in diabetics	Recruiting	Intervention	2019-07-04	<NULL>	<NULL>	2798	Use of music in pain relief during laser retinal photocoagulation in diabetics	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-12	NUBIA FRANCA PASSOS RIBEIRO	MARIA DO CARMO DE OLIVEIRA RIBEIRO	https://ensaiosclinicos.gov.br/rg/RBR-8nqywt	<NULL>	Have 18 years or more; to be submitted to the argon laser retinal photocoagulation procedure; have indication of bilateral achievement; perform the procedure due to very severe proliferative or nonproliferative diabetic retinopathy; and agree to participate in the survey after signing the consent form.	Alteration of auditory acuity; not liking music or associating it with negative experiences; have already performed the procedure previously; and have taken painkillers for the past six hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5prgcn	The use of a Therapeutic Tool to reduce symptoms of Depression	Data analysis completed	Intervention	2018-05-07	<NULL>	<NULL>	2799	The use of Biofeedback in reducing depressive symptoms in users of Psychiatric Outpatient Clinic and Psychosocial Care Center: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5prgcn	<NULL>	18 years of age or older; being accompanied in the service due to depression; being on medication for depression; meet the criteria of the International Neuropsychiatric Interview (MINI) for depression; present scores from 20 to 63 of the Beck Depression Inventory (BDI)	Persons in acute stage of hallucination and dissociation; in dependence on psychoactive substances, except nicotine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-59759n	Exposure to UV rays and dermatological verification of the appearance of allergies and / or irritations.	Recruiting	Intervention	2019-07-04	<NULL>	<NULL>	2800	Dermatological evaluation of photoirritant potential and topical photosensitizing	<NULL>	1-2, single-arm-study, single-blind	1-2	<NULL>	<NULL>	<NULL>	2019-04-16	Medcin Instituto da Pele Ltda.	Medcin Instituto da Pele Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-59759n	<NULL>	Participants of both sexes; Age between 18 and 70 years; Phototypes: II or III according to the adapted scale Fitzpatrick Appendix 1; Skin of the intact test region;	Pregnancy or risk of gestation, lactation when women; Prediction of bathing by sea, pool or bath during the study; Water sports practice during the study; Historical Personal of Atopy; History of sensitization or photosensitization to topical products; Previous history of pathologies worsened or triggered by ultraviolet radiation; Use of anti-inflammatory drugs up to 30 days before selection or immunosuppressants up to 03 months before; Immunosuppression by drugs or active diseases; Endocrinopatias descompensadas; Use of fotossensibilizantes drugs; Active cutaneous pathologies that may interfere with the results of the studies; History or activity of photodermatoses; Dermografismo; Personal or family history of skin cancer; Presence of precursor lesions of cutaneous neoplasia, such as melanocytic nevi and Actinic keratoses; Intense solar exposure in the test area; Use of new medications, cosmetics during the study; participation before in a study with the same product; Relevant clinical history or current evidence of alcohol or other drug abuse; Use of oral or topical treatment with vitamin A acid and or its derivatives up to 1 month before the beginning of the study; Known history or suspicion of intolerance to any ingredient in the study products,test or comparative products; Aesthetic and or dermatological treatment in the body within 03 weeks before selection; Scheduled vaccination during the study period or up to 03 weeks before selection; Other conditions considered by the researcher as reasonable for disqualification of the participation of the study. If yes, it should be described under observation in the clinical form; Employees of Medcin or the sponsoring company involved in the study, or close family member of an employee involved in the study; History of lack of adherence or lack of willingness to adhere to the study protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-6dn3mm	A pilot study evaluating the efficacy of the 204 LEDs helmet in men with initial vertex hair loss	Recruiting	Intervention	2019-07-04	<NULL>	<NULL>	2801	A pilot study evaluating the efficacy of the 204 LEDs helmet in men with initial vertex Androgenetic Alopecia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Every Eletroeletrônica Importação e Exportação LTDA – EPP	Every Eletroeletrônica Importação e Exportação LTDA – EPP	https://ensaiosclinicos.gov.br/rg/RBR-6dn3mm	<NULL>	Male volunteers; with shaved hair or who agree to shave the hair for maximum 1 mm length in all interest areas for tricoscopy analyzes; Age between 18 and 65 years, with clinical and tricoscopic diagnosis of androgenic alopecia grade III vertex and IV of Hamilton-Norwood; who attended at the dermatology clinic of the “Hospital Regional da Asa Norte”; Have signed the free and informed consent form; Have signed the authorization for use of image for research, medical publication and dissemination purposes.	Carriers of: uncompensated thyroid disease; anemia or ferritin below 20 mcg/L; FAN with titration greater than 1/320 of any pattern except nuclear fine dot pattern; VDRL with titration greater than 1/8; Carriers of other forms of non-androgenetic alopecia, such as: telogen effluvium, alopecia areata, lichen planopilaris, discoid lupus of the scalp, trichotillomania, among others; Scar at the site of the tricoscopy; Individuals with white or very light hair in color that make difficult the tricoscopic analysis and that do not accept to dye all their hair for the global and tricoscopic pictures; Individuals with hair dye allergy when necessary to use it; Individuals who are using drugs with androgenic or anti-androgenic properties, chemotherapeutic agents, finasteride or others 5-alpha-reductase inhibitors; Individuals who have performed any type of treatment for androgenetic alopecia in the last 6 months, such as finasteride, minoxidil, corticosteroids, 17-alpha-estradiol, ketoconazole, laser/LED, microneedling; Individuals who have had any flavivirus disease in the last 6 months have undergone any type of major surgery requiring anesthesia with sedation, large weight loss or other known cause of telogen effluvium; as well as at any time have undergone bariatric surgery or hair transplantation at the tricoscopy site; Individual has not used the device under study for at least 4 different days per week or if it has not been used for more than 7 consecutive days and also used more than 7 times per week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-7dghjm	Effect of Mental Stress on vascular response in Resistant Hypertension	Recruiting	Intervention	2019-07-05	<NULL>	<NULL>	2802	The role of Nitric Oxide pathway on vascular response to Mental Stress in Treatment-resistant Hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-7dghjm	<NULL>	40 to 65 years; diagnosis of essential hypertension; adherence to the treatment confirmed; blood pressure of at least 140 to 85 mmHg despite treatment with three anti-hypertensive drugs; blood pressure less than 130 to 85 with the use of four or more antihypertensive drugs.	Secondary hypertension; diabetes mellitus; stage III, IV and V chronic kidney disease; coronary artery disease; cerebrovascular disease; hepatic insufficiency; ophthalmologic disorders; regular use of nitric oxide donor drugs; stimulators of guanylate cyclase; pregnancy or lactation; current abuse of alcohol or other drugs; severe past drug allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-33rnjf	Classification of the baby who was born with low weight in Undernutrition or Preterm birth according to the response of his skin to light, a validation for the Preemie-Test	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	2803	Prematurity or Intrauterine Malnutrition? Clinical Trial for classification of the low-weight newborn through the optical properties of the skin, a validation for the Preemie-Test	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-33rnjf	<NULL>	Alive newborn. Be until the first 24 hours of life. Be equal or more than 24 weeks of gestational age at birth. Birthweight less than 2500 grams. Fetal had an obstetric ultrasound assessment before 24 weeks of pregnancy or pregnant women had trustable last menstrual period. Regarding the nested control case study be newborn with diagnosing of neonatal respiratory distress syndrome or transient tachypnea assessed until 72 hours after birth. Controls will be randomly paired by ranges of gestational age.	Be malformatted with a compromise of the structure of the skin. Has anhydramnios or fetal hydrops or genodermatoses or chorioamnionitis. In the nested case-control study present extrapulmonary conditions with tachypnea not due to prematurity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5btyvr	Effects of Aquatic Physiotherapy on the function, quality of life and risk of falls in the elderly in Curitiba	Data analysis completed	Intervention	2019-07-05	<NULL>	<NULL>	2804	Effects of Aquatic Physiotherapy on functional capacity, quality of life and risk of falls in the elderly in Curitiba	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade Dom Bosco	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5btyvr	<NULL>	Elderly aged 60 years or over; being on the waiting list for hydrotherapy at the Pardinho Ombudsman&apos;s Physical Activity Center	Elderly people with urinary or fecal incontinence will be excluded; open wounds; infectious cutaneous diseases; infectious diseases; uncontrolled blood pressure; recent postoperative period; cognitive alteration that prevents completion of the questionnaire; participation in another program of physical activity or physiotherapeutic rehabilitation; elderly with severe neurological and cardiac problems; or any other clinical problem that would contraindicate the performance of the tests and exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-3v3dqf	Effects of High Intensity Interval Training (HIIT) on Metabolic, Inflammatory, Arterial Stiffness and Myocardial Deformation in Obese women: a Randomized Clinical Trial	Not yet recruiting	Intervention	2019-07-05	<NULL>	<NULL>	2805	Effects of High-Intensity Interval Training (HIIT) on Metabolic, Inflammatory Parameters, Arterial Stiffness and Myocardial Deformation (STRAIN) in Obese women:a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-16	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3v3dqf	<NULL>	Be female; be between 18 and 35 years of age; present a picture of obesity (BMI: greater than or equal to 30 kg/m²); individuals with body weight stabilized for at least 12 weeks; who have not participated in weight reduction programs before; not suffering from cardiopathies, diabetes and / or hypertension and endocrine diseases; non smokers; who are not making use of medicines that can alter cardiorespiratory and neuromuscular systems; with readiness to participate in evaluations and interventions; and signing of the Informed Consent Form (TCLE).	Volunteers who present in the clinical evaluation and / or laboratory tests any pathology or other complications that may be risk factors or adhesion to the regular practice of the proposed physical activity; and any other condition that could interfere with the test and /or intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-46hk7r	Effects of the Use of Rehabilitation Respiratory Instruments in Elderly with Voice Problems	Not yet recruiting	Intervention	2019-07-08	<NULL>	<NULL>	2806	Effects of the Use of Respiratory Instruments in the Rehabilitation of the Elderly with Dysphonia: A Randomized Clinical Trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-46hk7r	<NULL>	patients aged over 60 years; of both sexes; with otorhinolaryngological diagnosis of dysphonia; who agree to participate in the study through the signing of the informed consent form	Patients with neurological and / or psychological disorders; patients miss more than one therapy session; will be excluded; and / or patients who have undergone previous or simultaneous speech-language therapy will not participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-8ghcx3	Effects of Type II Collagen Association on Muscle Strength in Pain and Function of Patients with Knee Arthrosis	Recruitment completed	Intervention	2019-07-08	<NULL>	<NULL>	2807	Effects of the combination of the non-denatured collagen type II (UC-II®) and the Russian current muscle reinforcement on the pain and function of patients with osteoarthritis of the knee: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8ghcx3	<NULL>	Men and women 40 to 75 years of age (this age group is justified because it covers the subjects with the stage of evolution of osteoarthritis of degree I to III); Unilateral and bilateral knee osteoarthritisfor more than three months with classification I to III in the radiological classification of Kelgren Lawrence confirmed by orthopedic doctor; Functional score of Lequesne higher than 4.5; Availability of dedication to treatment during the study period (six months); Patient agrees not to initiate any new physical or drug therapy for knee OA during the study period; Have signed the Term of Free and Informed Consent.	Grade IV knee osteoarthritis in the Kellgren-Lawrence radiological classification confirmed by orthopedist; Non-ambulatory; History of inflammatory arthropathy, septic arthritis, rheumatoid arthritis, inflammatory joint disease, uric acid gout, joint fracture, fibromyalgia, collagen genetic disease; Neurological diseases leading to cognitive deficits; History of asthma or type I or II diabetes; Psychiatric disorders; Symptomatic heart disease; Patients with clinical manifestations that do not allow the accomplishment of exercises; Presence of a skin or other type of skin disease at the level of the thigh; Urinary incontinence; Pregnancy; Alcoholism; Cancer; Patients with previous history of joint infiltration of corticoid or viscossuplementation in the knee in the last three months; History of trauma or knee surgery in the last six months; Three consecutive absences not justified physical rehabilitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9jxvpp	The physical exercise in the treatment of chronic non-specific back pain: a comparative study between bodybuilding and exercises without machines or dumbbells.	Data analysis completed	Intervention	2019-07-08	<NULL>	<NULL>	2808	The physical exercise in the treatment of non-specific chronic low back pain: a comparative study between bodybuilding and functional training.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jxvpp	<NULL>	The study sample will be composed of patients attended at the outpatient clinic diagnosed with chronic non-specific back pain of both sexes aged 18-65 years.	Patients who have undergone surgery in the spine; who are severely obese; pregnant; or who present with disabling pain to practice exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-78jx54	"Clinical and radiographic comparison of bone loss around external hexagon and cone morse implants, rehabilitated
with low platform and conventional platform connections"	Recruiting	Intervention	2019-07-09	<NULL>	<NULL>	2809	Clinical and radiographic comparison of peri bone remodelingimplant in external hexagon and cone morse implants, rehabilitatedwith reduced platform and conventional platform	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-78jx54	<NULL>	"Selected individuals must be over 18 years of age and perfect
state of general health (physical and mental). To have bilateral absence of posterior teeth in
upper and / or lower arch (Kennedy Class I, 1925) and adequate bone volume; not
grafted; for the installation of at least 2 adjacent implants (Strong SW, S.I.N.
Implants, Brazil) on each side of the arcade (upper or lower). The opposing archway shall
have natural teeth and / or fixed prostheses on teeth or implants."	"Underage and / or alcohol dependent patients; drugs; medicines;
smoking; pregnant women; or who have some systemic disease; such as diabetes
controlled; coagulation disorders; allergy; heart problems or other diseases
significant; that can influence the long-term follow-up; Or the
osseointegration; be immediately deleted. Patients with partial dentures
removable; dentures and / or overdenture; shall be excluded from the sample."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9z5t9q	The efficacy of electrical stimulation to control the symptoms of nausea and vomiting in pregnant women.	Not yet recruiting	Intervention	2019-07-09	<NULL>	<NULL>	2810	TENS efficacy on the control of nausea, vomiting and hyperemesis gravidarum in pregnant women: a randomized, blind, placebo-controlled clinical trial.	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-9z5t9q	<NULL>	Pregnant women with symptoms of nausea (defined as an uncomfortable sensation associated with a desire to vomit), vomiting (defined as oral expulsion of gastric contents), and hyperemesis (characterized by persistent nausea and vomiting leading to dehydration, ketosis, (with a weight loss greater than 5% of the total weight), triggered during gestation, which compromise women&apos;s quality of life (classified with a minimum of 3 points evaluated by numerical scale of 0 to 10 points); aged 18 years or over and medical follow-up during prenatal care.	Alteration of pain and tactile sensitivity (assessed by Buck hammer needle test and esthesiometer) or presence of skin lesion in the upper limbs; Presence of a cardiac pacemaker; Gestation of risk; Carriers of neurological abnormalities; cardiopathies; cognitive disorders and physical limitations that make it impossible to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-9s7wzm	Tomographic evaluation of palatal thickness in donor areas of soft tissue grafts filled with a collagen membrane.	Recruitment completed	Intervention	2019-07-09	<NULL>	<NULL>	2811	Tomographic evaluation of palatal mucosa thickness in donor areas of connective tissue grafts filled with collagen matrix: a randomized split-mouth clinical study	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9s7wzm	<NULL>	"Patients with multiple gingival
recessions that required connective tissue graft for root coverage, with the need of two donor area in the palate because of the extension of the receptor area; Good systemic health (ASA I); The sample unit will be the number of donor areas evaluated."	Active periodontal disease; Periodontal pockets or recessions in the palatal area greater than 5 mm; History of collagen hypersensitivity; Use of a removable partial prosthesis or mucosal-borne orthodontic devices in the maxilla; History of surgery on the palate; Use of medication that affects the periodontal tissues, such as cyclosporin A, phenytoin and calcium channel blockers; Smoking habits; Alcohol drinkers; Pregnancy and lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-59s47z	Influence of electroacupuncture parameters on brain stimulation in healthy individuals	Recruiting	Intervention	2019-07-10	<NULL>	<NULL>	2812	Influence of electroacupuncture parameters on cortical excitability in healthy individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-02	Laboratório de Eletroestimulação Funcional da Universidade Federal da Bahia	Laboratório de Eletroestimulação Funcional da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-59s47z	<NULL>	Healthy subjects aged between 18 and 45 years.	Subjects who have any disease or condition that is contraindicated the use of Transcranial Magnetic Stimulation. Any subject that has the following characteristics: have metallic implants in the skull or body; use cardiac pacemaker; history of convulsion; have chronic pain; pregnancy; use drugs that interfere with brain electrical activity; central or peripheral nerve injury affecting the upper limb; or be unable to understand the content of the evaluation tools used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-539d97	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	Not yet recruiting	Intervention	2019-07-10	<NULL>	<NULL>	2813	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Fisioclinic	Fisioclinic	https://ensaiosclinicos.gov.br/rg/RBR-539d97	<NULL>	Patients with symptoms of cervical pain, diagnosed with subacute or chronic mechanical neck pain;Chronic mechanical neck pain (CMC);Patients with limitation in the opening of the mouth of less than 40mm, without the need to suffer symptoms in the ATM; Whole age (between 18 and 50 years old);With signed written consent;No difference of sex;Patients dysfunction or disorders in the high cervical	Any surgical intervention in upper limbs, head or spine at any time of their lives;Having received previous osteopathic treatment in the last two months;Having received medical treatment two weeks before the study;Refusal of the patient to participate in the study;Any Contraindication to the application of the treatment or evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-8dghsc	Evaluation of the effect of in-vein Lidocaine done on the surgery time on pain intensity and inflammatory substance concentration (IL-6) in patients submitted to Stomach Reduction Surgery by Video	Recruitment completed	Intervention	2019-07-10	<NULL>	<NULL>	2814	Evaluation of the effect of perioperative intravenous Lidocaine on pain intensity and IL-6 concentration in patients submitted to Laparoscopic Gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-18	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8dghsc	<NULL>	Patients of both genders; obese; ASA 1 or 2; aged between 18 and 60 years old; submitted to laparoscopic gastroplasty	Diagnosis of cardiac, renal, hepatic, respiratory, psychiatric, oncologic diseases; allergy to lidocaine; who receive any analgesics 1 week before the surgery, or who receive blood derivates during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-2y8f8r	Effect of Self-chosen Intensity of Aerobic Exercise on continuity and pleasure in practice, and factors associated with the health of adolescents with Obesity	Recruitment completed	Intervention	2018-02-05	<NULL>	<NULL>	2815	Effect of Self-selected Intensity of Aerobic Exercise on adherence, affective responses and factors associated with physical and mental health of adolescents with Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Federal Institute of Sertão Pernambucano	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2y8f8r	<NULL>	Adolescents should be classified as obese according to criteria of the Centers for Disease Control and Prevention (CDC, 2000) (BMI&gt; P95th); with pubertal maturational stage (stages 3 and 4) according to criteria established by Tanner (1976); considered fit to participate in a program of 12 weeks of physical exercises after cardiological evaluation (resting electrocardiogram).	Individuals who present self-reported genetic; metabolic; endocrine diseases; report chronic alcohol consumption; prior drug use; pregnancy during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-2qycn4	Pilates Method and Postural Balance in Adolescent Soccer Players	Data analysis completed	Intervention	2019-07-10	<NULL>	<NULL>	2816	Evaluation of postural control and functional capacity in children practicing regular exercise.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Unopar - Universidade Norte do Paraná	Unopar - Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2qycn4	<NULL>	"Adolescents soccer players aged between 13 and 15 years old, training 3 times a week, for at least 1 (one) year;

Parental Permission signed by Parents or Legal Guardians and Adolescent participant."	"Previous history of surgery in the musculoskeletal system;

Presence of musculoskeletal, respiratory, neurological and / or cardiovascular diseases;

Use of medication continuously or within 30 days prior to the evaluation day;

Have received or are receiving any type of treatment for postural changes or balance problems;

Have received or be receiving any type of treatment using the Pilates method."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5j5shc	The Effects of the Hook on Cervical pain	Not yet recruiting	Intervention	2019-07-11	<NULL>	<NULL>	2817	The effects of Diacutaneous Fibrolysis in the evaluation of pain, functional status and muscular activity in patients with Cervical pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	UFJF - Universidade Federal de Juiz de Fora - MG	UFJF - Universidade Federal de Juiz de Fora - MG	https://ensaiosclinicos.gov.br/rg/RBR-5j5shc	<NULL>	"Individuals female. Age between 18 and 45 years.
Complaint of cervical pain. They must sign the TCLE: Free and Informed Consent Term."	Prior surgery in the scapular girdle region. Have received infiltration in the scapular girdle region in the previous three months. Present acute active local inflammatory processes. Present contraindications to diacutaneous fibrolysis: have wounds or skin disorders in the region of the shoulder girdle, have vascular changes, be under current treatment with anticoagulant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-4ym2j4	Effects of the Pilates Method on the Overall Health of the Elderly	Recruitment completed	Intervention	2019-07-12	<NULL>	<NULL>	2818	Effects of the Pilates Method on morphological, functional and psycho-behavioral variables in the elderly of the university community of the Federal University of Bahia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4ym2j4	<NULL>	individuals capable of practicing physical activity;aged between the ages established; individuals who present good cognitive ability and are able to respond to the study questionnaires and perform the proposed tests.	diseases and / or physical / motor and / or intellectual problems and symptoms that make it impossible to apply the questionnaires and / or to carry out evaluative tests and the intervention activities proposed for this study and are outside the established age range	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-87ckkh	Pre-Exposure Prophylaxis (PrEP) effects on kidney	Recruiting	Observational	2019-07-12	<NULL>	<NULL>	2819	Renal Function assessment among people who uses Pre-Exposure Prophylaxis (PrEP)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-10-04	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-87ckkh	<NULL>	18 years old or older; normal renal function by the beginning of the study protocol with estimated glomerular filtration ratio greater or equal to 90 mL/min; systolic blood pressure less or equal to 130 mmHg and diastolic blood pressure less or equal to 90 mmHg; no diagnosis of diabetes mellitus	to decide withdraw from this study; to present adverse renal events not related to PrEP use; diabetes mellitus diagnosis during the observational procotocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-6wvd9t	Effect of Muscular Strengthening in different positions on hip muscle stiffness and hip and knee and foot movement in healthy and sedentary adults	Recruiting	Intervention	2019-07-17	<NULL>	<NULL>	2820	Effect of Muscular Strengthening on different ranges of motion on passive stiffness of lateral hip rotators and lower limb kinematics of healthy and sedentary adults a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-6wvd9t	<NULL>	Young. Sedentary. Healthy adults, eighteen years of age or older, who have a range of medial hip rotation of at least twenty-five degrees and lateral hip rotation of at least five degrees. Perform less than thirty minutes five days a week of moderate intensity aerobic activity, twenty minutes on three days per week of aerobic activity of vigorous intensity. Perform less than two days per week of muscle strengthening or endurance activities. Have not undergone surgical procedures or hip rehabilitation or suffered musculoskeletal injury to the lower limbs / trunk in the last six months.	Inability to perform the tests. Presence of muscle contraction during the passive stiffness test of RL of the hip. Pain reported during the procedure that prevents its correct execution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-9m3bsb	Comparison between conventional surgery reduction and radiofrequency ablation in the treatment of nasal obstruction	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2821	Comparison between conventional partial inferior turbinectomy and radiofrequency ablation in the treatment of inferior turbinate hypertrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina da Universidade de São Paulo	Supri	https://ensaiosclinicos.gov.br/rg/RBR-9m3bsb	<NULL>	"Nasal obstruction secondary to inferior turbinates hypertrophy.
Patients older than 12 years.
No satisfactory response to medical treatment with topic corticoesteroids and nasal saline irrigation for at least three months."	"Obstructive nasal septum deviation (Cottle classification grade 2 or 3 or anterior deviation).
Previous nasal surgery (except adenoidectomy).
Intolerance to procedures performed under local anesthesia.
Patients with multiple comorbidities, classified as ASA 3 or superior."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-49m54y	The Effects of Electrical Stimulation and Laryngeal Massage in Patients with Muscle Tension Dysphonia	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2822	Effects of Transcutaneous Electrical Nerve Stimulation and Laryngeal Manual Therapy on Muscle Tension Dysphonia: Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA	https://ensaiosclinicos.gov.br/rg/RBR-49m54y	<NULL>	Female patients, aged between 18 and 55 years, with speech-language diagnosis of Muscle Tension Dysphonia and who agreed to participate in the study by signing the informed consent form .	Patients with cardiac comorbidities, diagnosis of thyroid disorders or who have undergone previous laryngeal surgery; neurological diagnosis or other that compromises phonation self declared by the participants; and who have performed speech therapy prior to or concurrent with the study participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-9sfgs9	Foot orthoses in the prevention injury in runners	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2823	Effectiveness of foot orthoses in preventing injury in recreational runners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-16	Universidade Federal da Bahia	Cristiano Sena da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9sfgs9	<NULL>	Individuals with no running-related injury history in the last 3 months, and who have been running for at least 4 months without interruption for at least 1 time per week.	Individuals who presented history of surgeries at the lower end and those who refused to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-4xxwwj	Effect of Unripe Banana Flour on gut and uremic compounds in patients on Peritoneal Dialysis	Recruitment completed	Intervention	2018-12-20	<NULL>	<NULL>	2824	Effect of Unripe Banana Flour on gut microbiota and uremic toxins in patients on Peritoneal Dialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4xxwwj	<NULL>	3 months or more in peritoneal dialysis; adherence to dialysis treatment.	Use of prebiotics, probiotics, synbiotics and antibiotics within the previous 30-day period at the beginning of the study; Crohn&apos;s disease or ulcerative colitis; severe hepatic disease; cancer; serum positive for the Human Immunodeficiency Virus (HIV); peritonitis or infection at the exit site; stomach or bowel resection; pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-2pcvt4	Effect of Robotic Therapy and Exercise Therapy on the Rehabilitation of the Arm of Hemiparetic People After Stroke in the Chronic Phase	Recruiting	Intervention	2019-07-18	<NULL>	<NULL>	2825	Effect of Robotic Therapy and of Kinesiotherapy on the Rehabilitation of the Upper Limb of Hemiparetic Individuals After Stroke in the Chronic Phase	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-27	Universidade Metodista de Piracicaba - Programa de Pós Graduação em Ciências do Movimento Humano	Universidade Metodista de Piracicaba - Programa de Pós Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-2pcvt4	<NULL>	Age between 18 and 80 years; single episode of ischemic vascular brain lesion for at least 6 months; upper limb motor impairment graded by the Fugl Meyer Scale, with a score of 7 for upper limb; degree of spasticity less or iqual  3 as measured by Modified Ashworth scale in the brachial biceps muscle; no range of motion limitation greater than 10 degrees of elbow extension and 10 degrees of extension of the wrist, assessed by goniometer; is not included or has participated in a robotic therapy program; have not received botulinum toxin or other types of anti-spastic drugs in the last three months.	Aphasias and agnosias that preclude the understanding of the virtual tasks proposed for the intervention; subluxation of the shoulder (anterior and / or inferior) evaluated clinically by palpation (bigger than 2 cm); presence of severe pain in the movement of the shoulder, elbow or wrist.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-8t6c99	Dental implants installed and restored provisionally immediately after tooth extraction in the aesthetic region of the smile	Recruiting	Intervention	2018-12-18	<NULL>	<NULL>	2826	Immediate placement and provisionalization of implants in the aesthetic zone	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Odontologia - UERJ	Faculdade de Odontologia - UVA	https://ensaiosclinicos.gov.br/rg/RBR-8t6c99	80	Indication of treatment with immediate dental implants in the esthetic zone	Patients ASA III or more; Patients with systemic alterations that may interfere with osseointegration; Pregnant patients; breastfeeding patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-3f3vkj	Occurrence of Mental Diseases between Diabetics in tratament with Insulin	Data analysis completed	Observational	2019-07-15	<NULL>	<NULL>	2827	Occurrence of Psychiatric Disorders between Diabetics of type II in treatment with Insulin: A case-control study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-02-03	Universidade do extremo sul catarinense	Universidade do extremo sul catarinense	https://ensaiosclinicos.gov.br/rg/RBR-3f3vkj	<NULL>	"individuals aged 60 to 79 years;
Systemic Arterial Hypertension (SAH);
Acute Myocardial Infarction (AMI);
Encephalic  Vascular Accident (EVA)."	Under 60 and over 79; without some related pathology in the inclusion criteria; to have bipolarity and schizophrenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-69dnfz	Applying ICDAS  to decrease of the disallowance rate in Dental Care Delivery Systems	Data analysis completed	Intervention	2019-07-19	<NULL>	<NULL>	2828	Application and effects of ICDAS in Dental Audit	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-10-01	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-69dnfz	<NULL>	Dentists/auditors who worked in the accredited network for more than 1 year; who had professional experience of over 10 years; who freely accepted to participate in this study; dentists who performed large quantities of dental caries treatments in the dental care delivery system, before and during the study.	Dentists/auditors who were invited but who did not agree to participate in the study; dentists who did not perform caries treatments after receiving the training; dentists who participated in the training but did not reach an acceptable level of concordance regarding ICDAS (weighted Kappa Index equal to or greater than 0.75).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5g9wfg	Impact of pharmaceutical care on patients with type 1 diabetes mellitus seen through the judical actions.	Not yet recruiting	Intervention	2019-07-19	<NULL>	<NULL>	2829	Clinical and economic impact of pharmaceutical care in patients with type 1 diabetes mellitus seen through the judicial actions: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Federal de São João Del Rei	Universidade Federal de São João Del Rei	https://ensaiosclinicos.gov.br/rg/RBR-5g9wfg	<NULL>	Patientes with type 1 diabetes mellitus, who obtain their insulines through judical actions.	Bedridden patients who can not attend the place of pharmaceutical consultations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-4nnkfb	Effects of light therapy on physical performance and recovery of postmenopausal women submitted to a high intense exercise session	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	2830	Effects of Light-Emitting Diode therapy on physical performance, on inflammatory and oxidative stress markers, and on hemodynamic and cardiac autonomic responses of postmenopausal women submitted to a high intense exercise session	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4nnkfb	<NULL>	Women; amenorrhoea of at least 12 months; able to exercise; healthy; do not present functional limitations that prevent them from exercising on the treadmill; do not present chronic diseases (diabetes, hypertension and coronary artery disease) or any pathology that can prevent their participation in physical activity; do not perform hormone replacement therapy; do not use medications that may interfere in the results of the survey; non-smoker.	Chronic diseases (diabetes, hypertension and coronary artery disease) or any pathology that may prevent their participation in physical activity; use of hormone replacement therapy; the use of medications that may interfere with the results of the research; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-98jdt3	Aerobic exercise of high intensity for treating Apnea: the effects of intensity on the disease, on heart responses, and sleep quality	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	2831	Aerobic exercise for treating of Obstructive Sleep Apnea: effects of intensity on disease severity, hemodynamics, autonomic resposes and sleep quality	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-98jdt3	<NULL>	Men and women; obstructive sleep apnea (OSA) moderate to severe (apnea-hypopnea index greater than 15 events / hour); diagnosed by nocturnal polysomnography; between 18 and 75 years old; overweight or obese; sedentary; taking stable doses of medication; not having previous treatment for OSA; medical authorization to practice physical activity	Cardiovascular; pulmonary or metabolic disease; resistant hypertension (159/99 mmHg with more than three drugs); pregnant or unable to exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-72dv9n	The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil	Recruiting	Intervention	2019-07-22	<NULL>	<NULL>	2832	The Association of Miltefosine and Pentoxifylline to Treat Mucocutaneous Leishmaniasis: A Clinical Trial in Brazil	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-09-01	Pós Graduação de Ciências da Saúde - Universidade de Brasília	Pós Graduação de Ciências da Saúde - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-72dv9n	<NULL>	Inclusion Criteria: Mucosal and/or cutaneous leishmaniasis, not treated or at least 6 months without any treatment to leishmaniasis; ages between 18 and 80 years old; for patients with cutaneous lesions: duration of disease longer then a 1 month and shorter then 4 yeas; 1 to 3 lesions; larger lesions from 10mm to 50mm; fertile female patients should use at least two contraceptive methods (hormonal and barrier); agree to participate in the study and sign the informed consent term.	Exclusion Criteria: Use of any leishmanicidal drugs six months prior; clinical or laboratorial evidences of electrocardiographic disorders; renal, hepatic, cardiac diseases, uncontrolled diabetes or AIDS; hypersensitivity to meglucamine antimoniate; pregnancy or lactation; Fertile females that do not agree to use contraceptive methods; patients that do not agree to the informed consent term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-6p4jnf	The use of thermography as assistance in Triggers Points Diagnosis and Evaluation of Therapeutic Techniques	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2833	Use of Thermography as a Relevant Method in the Diagnosis of Trigger Points and in the Evaluation of Therapeutic Techniques	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-10-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6p4jnf	<NULL>	The sample will be composed of subjects who present a moderate level of pain (EVA-3) at the trigger points of the upper trapezius muscle during the clinical examination; which do not present coagulation dysfunctions; fibromyalgia; cervical radiculopathy; surgeries of head, neck, shoulder girdle; not on anti-inflammatory / acupuncture / muscle relaxant treatment.	If the evaluation does not appear; do not agree at any point in the study with the ICF; to give up at any stage of the research; or show Aicmophobia (fear of needles).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-36y2xg	Evaluation of the efficacy of the formulation of topical anesthesia of Lidocaine / Articaine 4% and Lidocaine / Prilocaine 2.5% with and without Sodium Bicarbonate in the mucosa located posterior to upper canine teeth	Not yet recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2834	Evaluation of the efficacy of the topical formulation of Lidocaine / Articaine 4% and Lidocaine / Prilocaine 2.5% with and without Sodium Bicarbonate in palatal mucosa of upper canines	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Sergipe	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-36y2xg	<NULL>	Criteria for inclusion of volunteers in the research: age between 18-35 years; ability to provide written consent; Undergraduate or graduate student of the dentistry department of the Federal University of Sergipe who has already undergone local anesthesia without intercurrences; Not having undergone anesthesia in the region in the two weeks prior to the study; Do not use medication that changes perception of pain in the 2 weeks prior to the study; Do not present systemic changes or a history of hypersensitivity to the drugs under study.	Individuals will be informed that it is permissible to leave the study at any time without any loss. The individual may be withdrawn from the study when he or she experiences an allergic reaction or clearly drug-related allergic reaction; To present non-drug-related systemic disease during the study, requiring concomitant therapy; Failure to comply with protocol requirements, including rules related to drug use, alcohol or lack of cooperation during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5qkn8h	Effect of one or two diuretics in patients with decompensated heart failure - a clinical trial	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2835	Effect of diuretic combination in patients with acutely decompensated heart failure - a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-09-03	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5qkn8h	<NULL>	Diagnosis of acutely decompensated heart failure; age greater than 18 years; male and female; emergency admission for less than 18 hours; signs of congestion (lower limb edema, pulmonary crackles, chest X-ray with signs of congestion, jugular swelling or hepatojugular reflux, weight gain greater than 4.5 kg); endogenous creatinine clearance greater than 30 ml / min; serum potassium between 3.5 and 5.1 mEq / L; ejection fraction equal to or less than 45% in the last 12 months; to sign a free and informed consent form.	Hypernatremia; Bartter or Gitelman syndrome; renal tubular acidosis type IV; allergy to sulfa; validity of acute coronary syndrome; history of gout; gestation or lactation; septic shock; hepatic dysfunction (elevation of transaminases three times the reference value); inability to enteral intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-8fvwxq	Impact of preventive child oral health programs in Primary Health Care	Data analysis completed	Intervention	2015-03-30	<NULL>	<NULL>	2836	Impact of preventive child oral health programs in Primary Health Care	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-8fvwxq	<NULL>	Children born in 2013/2014 in the attended territory of 12 Basic Health Units of the Community Health Service of Grupo Hospitalar Conceição, located in the city of Porto Alegre, Rio Grande do Sul, Brazil and who are correctly registered and under follow-up medical attention in the Children Program; Mothers/fathers/responsible adults: the person responsible for the child’s oral health care and who follows all dental appointments in the health unit will be considered.	Children with special needs or syndromes; children who left the attended territory of Community Health Service of Grupo Hospitalar Conceição health units for more than 6 consecutive months; Mothers/fathers/responsible adults without cognitive conditions to answer the study’s surveys.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-7jy2f7	methods of caries removal - A multicenter study	Data analysis completed	Intervention	2016-10-24	<NULL>	<NULL>	2837	partial versus complete removal of decayed tissue - a multicenter controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7jy2f7	<NULL>	Teeth with occlusal contact with the antagonist and proximal contact in cases of occlusal proximal restorations at baseline; active deep carious lesions in dentin limited occlusal and occlusal proximal surface of deciduous molars; lesion in the dentine deep to 1 mm separating the injury of the pulp and the pulp to the dentin amelo junction divided by 2 the lesion must be on the inner half of dentin; absence of clinical diagnosis of pulp exposure; absence of fistula; absence of swelling and mobility not compatible with root resorption; absence of clinical signs and symptoms of irreversible pulpitis; absence of radiolucency in the furcation or periapical region or spacing of the periodontal ligament; lack of internal or external root resorption pathological; 4 to 8 years old; both sexes; good general health; children whose parents read and signed the consent form;	patients suffering from bruxism; dental erosion; fluorosis and severe hypoplasia; patients with motor problems;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-9nqszr	Different materials for the Atraumatic Restorative Treatment technique in deciduous teeth, a clinical investigation	Recruitment completed	Intervention	2017-08-24	<NULL>	<NULL>	2838	"Randomized double blind clinical trial using different materials on teeth
By ART technique: three years of follow-up"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9nqszr	<NULL>	"Healthy volunteer children; Both genders;
Duly enrolled in municipal or state schools;
With an acceptable oral hygiene level; With
a minimum of 4 years and a maximum of 9
years."	"Children who do not accept oral examination or restoration; Those that are missing on the scheduled restoration day; Those whose managers do not sign the Free and Informed Consent Form; Teeth with very deep carious lesions; Fistulated
teeth; With such spontaneous pain."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-3ddg2k	Effects of treatment of painful shoulder muscle nodules on shoulder pain, mobility, and muscle function in individuals with shoulder pain	Data analysis completed	Intervention	2018-07-10	<NULL>	<NULL>	2839	Effects of ischemic compression therapy at myofascial trigger points on pain, mobility, and muscle function of the shoulder complex in individuals with shoulder pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3ddg2k	<NULL>	Presence of at least one active or latent PGM, on the symptomatic side, in one of the following muscles: upper trapezius, lower trapezius, supraspinatus, infraspinatus, minor pectoris and middle deltoid.The subjects should have a history of unilateral shoulder pain, lasting more than one week, located in the proximal anterolateral region of the shoulder, or in the C5 or C6 dermatome region; Least three of the special tests for SIS diagnosis considered positive: Neer test; Hawkins&apos; test; Jobe&apos;s test; Painful arch test; External rotation resistance test; Gerber test and Speed biceps test.	Signs and symptoms of bilateral SIS;Primary adhesive capsulitis; Reproduction of shoulder pain which radiates to the entire upper limb; Numbness or tingling in the upper limb or any other symptom in the upper limb during foraminal compression test; History of symptom onset due to glenohumeral displacement or subluxation; Joint deformation in the glenoid or humeral head; Or fracture of the clavicle, scapula or humerus;History of surgical stabilization or repair of the rotator cuff;Groove test or positive seizure test;Signs of complete rupture of the rotator cuff, as evidenced by the positive fall test; Systemic disease involving joints such as rheumatoid arthritis and systemic lupus erythematosus and fibromyalgia, which involves myofascial tissue;Neurological pathologies; Use of analgesics and muscle relaxants 72 hours before the evaluation;Use of corticoid injection 3 months prior to evaluation;Body mass index (BMI)&gt; 28kg /m2;Symptoms of depression, with score 13 in the Beck Depression Inventory;Be there for a period of 1 month without participating in any program of physiotherapeutic treatment, stretching, strengthening or specific resistance exercises for the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-474xhn	Preoperative vessel ultrasound of surgical accesses for hemodialysis: A study of viability for use in the Single Health System (SUS)	Recruiting	Intervention	2018-01-26	<NULL>	<NULL>	2840	Preoperative doppler ultrasound of arteriovenous fistulas for hemodialysis: A study of viability for use in the Single Health System (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade de Medicina do ABC - SP	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-474xhn	<NULL>	Adult patients (age  bigger then 18 years); both genders; stable clinical condition; arterial lumen diameter bigger ou equal 2.0 mm and venous bigger ou equal 2.5 mm; axillary vein diameter bigger ou equal 4.0 mm for fistulas with expanded polytetrafluoroethylene (PTFE) prosthesis; absence of stenosis or thrombosis in the central venous system; absence of segmental stenoses or occluded arterial segments; patent palmar arch (Allen test); study authorization.	Does not fit inclusion criteria; patients who perform Doppler Ultrasound privately.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-72qkvy	Acupuncture and Phytotherapy in Anxiety control	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2841	Acupuncture and Phytotherapy in anxiety control with accompanying by the Bioeletrography technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-72qkvy	<NULL>	Individuals over 18 years of age with anxiety and / or VAS complaints for anxiety greater than 4.	Individuals who perform some drug treatment for anxiety and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-8jc5dp	Homeopathy in the integrative treatment of knee osteoarthritis	Recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2842	Homeopathy in knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-10	Unidade de Saúde Escola da Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8jc5dp	<NULL>	Women and men 50 to 75 years old with a knee osteoarthritis diagnosis (according to the American College of Rheumatology criteria) in at least one knee compartment (tibiofemoral and/or patellofemoral).	Grade 1 or 4 in Kellgren and Lawrence radiologic classification of osteoarthritis; other inflammatory chronic diseases with musculoskeletal impairment; regular use of duloxetine or similar; use of anti-inflammatory drugs. Analgesic scape medication will be allowed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5fr3qm	Light emitting diode (LED) action in the Pain control ater wisdom teeth Extraction	Recruitment completed	Intervention	2019-07-24	<NULL>	<NULL>	2843	Light emitting diode (LED) Photobiomodulation action in the control of third molars&apos; Post Exodontia Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Departamento de Odontologia da Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5fr3qm	<NULL>	ASA I or II patients who have extraction of 3rd molars indication with the same anchor position according to the classification of Pell and Gregory. Aged between eighteen and thirty years.	ASA III and IV Patients. Presence of periodontal problem. Use of antidepressants of any kind. Parafunctional habits. Smokers. History of hypersensitivity reaction to the LED (LED). History of previous pericoronarite. Odontophobic. Individuals under the age of eighteen or over the age of thirty. Diabetics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-8d755f	Respiratory muscle training in patients with respiratory diseases	Data analysis completed	Intervention	2019-07-24	<NULL>	<NULL>	2844	Respiratory muscle training in COPD patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual Paulista Rio Claro	Universidade Estadual Paulista Rio Claro	https://ensaiosclinicos.gov.br/rg/RBR-8d755f	<NULL>	Diagnosis of COPD according to the Global Initiative for Chronic Obstructive Lung Disease- GOLD; 18 to 90 years; clinically stable for at least four weeks; no smokers for at least six months,both genres.	Do not perform all the tests proposed; not to attend at least 85% of the training protocol; to present exacerbation of the disease during the period of application of the protocol; present need for hospitalization for any reason; hospital admission history in the last four weeks prior to the start of training; clinical instability; diagnosis of associated disease that prevents the performance of any of the proposed activities; participation in any pulmonary rehabilitation program; not to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-9wsg72	Effects of laser on preventing decreased sensitivity in women with breast cancer during chemotherapy	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2845	Effects of laserpuncture in the prevention of altered tactile sensory perception in women with breast cancer during chemotherapy: randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2018-07-05	Universidade Federal de Minas Gerais	Hope Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-9wsg72	<NULL>	"Pathologic anatomic report of cancer;
Beginning of treatment with antineoplastic chemotherapy containing taxanes, platines, vinca alkaloids and bortezomib alone or in combination;
Absence of PSTA, identified by symptom reporting and stoichiometry test;
Adults above 18 years."	"Hoseniasis;
Diabetes melittus;
Cognitive deficits;
Other neuropathies, including those caused by tumor infiltration;
Absence of verbalization;
Pregnant;
Performance Status greater than or equal to 3;
Acupuncture in the last 6 months for neuropathy;
Alcoholism;
Skin problems in the irradiated area;
Presence of the tumor at the irradiation sites."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-2dwbjg	Effect of a dietary supplement on fatigue and quality of life of women with Breast cancer	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2846	Effect of Paullinia Cupana on fatigue and quality of Life of women with Breast cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2dwbjg	<NULL>	Individuals of the female gender; age group greater than or equal to 30 years and up to 59 years in any antineoplastic treatment; living in the city of São Luis. Disease stage I to III.	Men or women pregnant or in stage four of the disease. Age under 30 or greater than 59 years. Individuals who can not communicate verbally or move. With mental disorders; grade three to four nausea; anorexia or do not want to continue in the study or have any kind of complication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-7qvtjk	Study of vitamin D and health conditions in pregnant women with Gestational Diabetes	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2847	"Study of vitamin D and perinatal outcomes in pregnant women with Gestational Diabetes:
a controlled clinical trial"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal do Rio de Janeiro	Maternidade Escola da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7qvtjk	<NULL>	The criteria for selection of pregnant women in the groups will be: adults (chronological age&gt; 20 years at conception), diagnosis of Gestational Diabetes Mellitus with gestational age &lt;28 weeks, single fetus gestation, nonsmokers.	As exclusion criteria: pregnant women with other chronic diseases, such as renal or hepatic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-4r26fz	Application of the knowledge, skill and attitude questionnaire regarding the Monitors used in the Intensive Care Unit	Data analysis completed	Intervention	2019-07-24	<NULL>	<NULL>	2848	"Application of cha inventory (knowledge, skill and attitude) and intervention,
the use of multiparametric monitors in an intensive care unit"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Triângulo Mineiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-4r26fz	<NULL>	The entire nursing team (nurses and technicians) was included in the survey, which currently comprises the staff of the chosen services. Thus the inclusion of all the team was intentional, considering the particular characteristics of the study group. For this purpose, they agreed to participate in the study, by signing the Term of Clarification for the participants, as well as the Free Consent Form after Clarification for Participants prepared according to Resolution 466/12 of the National Health Council (BRAZIL, 2012).	Those who were on maternity leave and leave were excluded from the study. As the forecast for the data collection was three months in some situations it was not possible to wait for the return of employees who were away for health or maternity leave. Those professionals who were reassigned from sectors, dismissed or did not participate in all stages of the research (regarding pre- and post-intervention) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-4287s4	Evaluation of neuromuscular electrical stimulation with Aussie current in muscle resistance	Recruiting	Intervention	2019-07-24	<NULL>	<NULL>	2849	Effects of the Aussie current on the strength gain of the quadriceps muscle	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-24	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-4287s4	<NULL>	Age range 18-28 years; male; sedentary for at least six months	Any type of disease contraindicated to perform physical exercises and electrostimulation; have musculoskeletal pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-82tv5q	Effect of simulation in the nursing student&apos;s knowledge	Recruitment completed	Intervention	2016-05-28	<NULL>	<NULL>	2850	Effect of simulation in the nursing student&apos;s knowledge about cardiopulmonary resuscitation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal do Rio de Janeiro	Fundação Educacional de Macaé	https://ensaiosclinicos.gov.br/rg/RBR-82tv5q	<NULL>	Second or third year degree in Nursing; to have 18 years old or more, have not had prior contact with courses or first aid and emergency training.	Technical training in nursing; Professional role as technician or nursing assistant; having first aid training; participate in research projects or extension that deal with the subject.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-46xr4r	Evaluation of the effect of immersion in ice water for recovery after physical exercise application on subjective and objective performance measures	Recruiting	Intervention	2019-07-25	<NULL>	<NULL>	2851	Evaluation of the specificity of the effect of post-exercise cold water immersion on subjective perception variables and on mechanical and physiological variables of neuromuscular origin after the application of tensional and metabolic physical stimulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-08	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-46xr4r	<NULL>	Soccer players or long distance runners; age between 18 and 40 years; minimum training frequency twice a week	Report of systemic diseases and / or chronic or acute musculoskeletal injuries in the last six months; use of drugs that act on the cardiovascular and / or autonomic system; cold intolerance; hemodynamic conditions that contraindicate the tests performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-45dh3r	Effect of Sweet Orange Aroma on Pregnant Women in Labor	Recruitment completed	Intervention	2019-07-29	<NULL>	<NULL>	2852	Evaluation of Effect of Aromatherapy with Essential Oil of Sweet Orange (Citrus sinensis L.) no Pain Relief in Pregnant Women in Labor	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-14	Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe	Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-45dh3r	<NULL>	"Term pregnant women (gestational age ? 37 weeks) attended at Maternity Zacarias Júnior in the municipality of Lagarto-SE with indication of normal delivery in the active process of labor;
Pregnant women with cervical dilatation from 4 cm;Greater than 18 years; Sign the Free and Informed Consent Form -"	"Pregnant women who report allergy or intolerance to Citrus sinensis L .;
Pregnant women who report problems with their sense of smell;Pregnant women who report depression, anxiety;Pregnant women presenting with pregnancy morbidities who do not complain of pain in the evolution of labor;  Under 18 years old;  Pregnant women who do not agree to sign the Free and Enlightened"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-27wqm5	"The Effect of Acupuncture on Anxiety in
undergraduate student"	Recruitment completed	Intervention	2019-07-29	<NULL>	<NULL>	2853	"The Effect of Acupuncture on Anxiety in
undergraduate students in the pre-examination period: a randomized, cross-over study"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-27wqm5	<NULL>	with no previous experience with acupuncture; without history of psychotropic or opioid medication use ; without disease that limits the use of acupuncture	previous experience with acupuncture; history of use of psychotropic or opioid medication; disease limiting the use of acupuncture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-58dy3y	The Effects of Crocheting physiotherapy in the assessment of pain, mobility, functional status and muscle activity in patients with Temporomandibular disorders	Recruitment completed	Intervention	2018-06-13	<NULL>	<NULL>	2854	The Effects of Diacutaneous fibrolysis in the assessment of pain, mobility, functional status and muscle activity in patients with Temporomandibular disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-58dy3y	<NULL>	Volunteers who have temporomandibular pain lasting more than 06 months; Who have a permanent dentition with at least 28 permanent teeth; Without periodontitis	Volunteers who have already suffered craniofacial trauma; who have performed previous surgery on the affected temporomandibular joint, rheumatic diseases; volunteers who use analgesics; anti-inflammatory; patients with neurological or cognitive deficits, and who have contraindications to diacutaneous fibrolysis (wounds or skin disorders in the TMJ region, vascular changes, receiving anticoagulant treatment)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-3zyq7b	Intestine manipulation and functionality in patients with intestinal constipation	Not yet recruiting	Intervention	2019-07-31	<NULL>	<NULL>	2855	Intestine manipulation and functionality in patients with intestinal constipation: randomized controlled double blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Colegio Brasileiro de Osteopatia	Colegio Brasileiro de Osteopatia	https://ensaiosclinicos.gov.br/rg/RBR-3zyq7b	<NULL>	Inclusion criteria will be adults; of both genders; aged between 18 and 60 year;s and who present a complaint of Chronic Intestinal Constipation (more than 6 months), that fit the definition of Functional Constipation in the Rome Consensus III;	Adults with an incision or tumor in the abdominal region; fractures; rheumatic diseases; acute infectious disease; or impossibility of understanding the proposed evaluations will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-5974nc	Effect of electrical stimulation on menstrual cramps	Data analysis completed	Intervention	2019-07-31	<NULL>	<NULL>	2856	Therapeutic effect of high and low frequency transcutaneous nervous electric stimulation in pelvic pain caused by primary dismenorrhea syndrome: a comparative study	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-06-01	SOBEU - Associação Barramansense de Ensino	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-5974nc	<NULL>	Age between 18 and 35 years; pelvic pain caused by dysmenorrhea; being between the first and third day of the menstrual cycle, degrees between 1 and 10 on the Visual Analogue Pain Scale (EVA)	Age inferior to 18 and superior to 35 years; use of analgesics and other therapies for pelvic pain; gynecological conditions; undiagnosed abdominal pain; heart pacemaker; cardiac complications; degree 0 on the Visual Analogue Pain Scale (VAS).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-53hjzk	Diferent doses of lactase in subjects with intolerance lactose	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	2857	Clinical trial for the evaluation of the efficacy and safety of lactase different oral dosages upon intestinal symptoms and hydrogen breath excretion in patients with hypolactasia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-04-15	Nutracom Indústria e Comércio Ltda.	Instituto Claudia Marques de Pesquisa e Desenvolvimento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-53hjzk	<NULL>	"Volunteers diagnosed with lactose intolerance;
Volunteers with genotype CC - not persistent Lactase (intolerance to lactose); Volunteers of both sexes (male or female) aged 18-55 years; BMI between 18.5 and 30 kg / m2; Good health or without significant disease, the medical judgment, in accordance with the rules set out in the protocol; Able to understand the nature and purpose of the study."	"Volunteer known to have hypersensitivity reaction known to the study of the product (lactase) or the formulation excipients including lactose; maintenance therapy for use with any drug that interacts with lactase or interferes in the results of the breath test, except for contraceptives; Treatment with laxatives, antibiotics, prokinetic (eg, metoclopramide, domperidone, cisapride and others.), Or any drugs known to influence the colonic flora or gastrointestinal motility in the month prior to the study;
Use Vitamins and dietary supplements;
History or presence of liver, renal, pulmonary, cardiac, neurological or metabolic diseases; Malignancies; organic gastrointestinal diseases; secondary hypolactasia; reported anemia or proven from the results of laboratory examination of blood count; Giardiasis and strongyloidiasis proven from the results of laboratory parasitological examination of stool; Diabetes reported or confirmed; Hypoglycemia proven from the results of laboratory examination of plasma glucose: below 55 mg / dl for men and 45 mg / dl for women;
Diseases which cause damage in the intestinal mucosa, diseases that significantly increase the gastrointestinal transit as infectious enteritis, celiac disease, inflammatory bowel disease (Chron), drug-induced enteritis or radiation, diverticular disease of the colon; History of surgery: heart (whatever), renal (exercises kidney or renal agenesis), intestinal (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon or rectum) , liver or pancreas; Volunteers smoking more than five cigarettes a day; different eating habits of the population standard, eg vegetarianism, veganism; History of alcohol consumption or use of drugs of abuse; Made use of antibiotics as regular medication (continuous use) within the 4 weeks preceding the valuation date and / or the start of the breath test; This examination Colonoscopy one month before the breath test H2 expired. After the intestinal flora colonoscopy need to 4 weeks to recover; Use of antiparasitic drugs in the 30 days preceding the breath test H2 expired. Held bowel tests, for which intestinal cleaning was done; Participation in a clinical trial in the last 12 months before the beginning of the study; Diarrhoea on the H2 breath test expired; The volunteer has any condition that prevents him from participating in the study by the judgment of the physician clinical researcher; positive pregnancy test."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-9y2p2g	An intervention with sit-stand table for decrease sedentary behavior in office workers with overweight and obesity?	Recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2858	Can sit-stand table usage affect the level of physical activity and body composition in office workers with overweight and obesity?	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9y2p2g	<NULL>	To be eligible, the workers must report not suffering from chronic systemic health problems; performing computer work for at least four hours (continuous or not) in an ordinary working day; having been performing computer work for at least five years; having been off work for no more than one month during the previous year; workplace that would allow the installation and use of a sit-stand desk for six months.	Do not consent to the Free and Informed Consent Form; give up the evaluation stages, or do not use the table properly; present some acute musculoskeletal discomfort during the study intervention; present obesity II or III; women in the gestational period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-4v7bqx	The effects of massage on specific points in the feet and stimuli in points of the ear for the treatment of pain in the lumbar region of teachers and students of the health area of ??a university in the south of the country: clinical study	Recruiting	Intervention	2019-08-05	<NULL>	<NULL>	2859	The effects of Foot Reflexology and Auriculotherapy in the reduction of non - specific acute low back pain among health professors and students: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4v7bqx	<NULL>	"To be a professor and / or student of the health area at the University of Southern Santa Catarina;
availability to participate in all the sessions that the study establishes; have pain in the lower back; do not present lesions, scars, inflammatory or infectious processes that can compromise sensitivity, manipulation of auriculotherapy points and reflex areas of the fee;
being at least 18 years old and not older than 75 years old"	To be performing specific treatment for relief of low back pain, with another complementary practice; be participating in some other research for pain relief; be pregnant; have undergone surgery in the auricle that has altered the anatomy of the nerve terminals and the auricular structure; present vascular disorders in lower limbs such as varicose ulcers and  or thrombosis, severe diabetes with loss of peripheral sensitivity; have undergone surgery on the feet and are showing signs of scarring and tenderness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-3xr6dv	Oxibuprocaine eye anesthesic effect by Eyedrops or Spray	Recruiting	Intervention	2019-08-06	<NULL>	<NULL>	2860	Comparison between 0,4% Oxibuprocaine corneal anesthesia applied by Eyedrops or Spray	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-27	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-3xr6dv	<NULL>	Adult volunteers; both genders;  Consulted at the Policlinica Ronaldo Gazolla ophthalmological clinic;  Need to perform aplanation tonometry for intraocular pressure measurement.	Volunteers with corneal disease; Refusal in signing the informed consent; Mentally retarded that does not understand research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-7gn68p	Profile of protein expression of root canal infections	Data analysis completed	Intervention	2019-08-07	<NULL>	<NULL>	2861	Proteomic profile of endodontic infections	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista	Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7gn68p	<NULL>	A total of 6 patients were included in this study, 2 with normal pulp (orthodontic indication of extraction), 2 with pulpitis and 2 with chronic apical periodontitis. Therefore, the patients should present the pulp conditions mentioned and for the endodontic treatment of the teeth with inflammation and pulp necrosis, they should be able to be isolated with a rubber dam.	Patients without systemic disease. Patients whose teeth cannot be restored.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-9xnf8r	Chemistry evaluation and patients satisfaction in relation to carbamide peroxide bleaching gels: clinical trial	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2862	Evaluation of degradation, pH and patient satisfaction with 20-22% carbamide peroxide gel flavour in at-home bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Instituto de Ciência e Tecnologia de São José dos Campos	Instituto de Ciência e Tecnologia de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9xnf8r	<NULL>	minimum of 18 years old; good general health; patients who want to retouching of bleached teeth (bleaching treatment previously); abscence of gingival recession, non carious cervical lesion, active carie or periodontal disease; do not use fixed orthodontic appliances or removable prosthesis; pressent all teeth upper and lower sencond premolars; and avaiability for recurring returns	Chemical dependents, smokers ou alcoholics; medical conditions in which can interfere in volunteer security (medicines for the treatment of chronic diseases or allergic reactions to substances to be used); pregnancy; be in another study in the same period; present bruxism, periapical alterations ou tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-2h6sck	The Effect of Electrical Stimulation on Urinary Loss, Pelvic Muscle Strength, and Quality of Life of Patients After Prostate Cancer Withdrawal	Recruitment completed	Intervention	2019-08-07	<NULL>	<NULL>	2863	The effect of Electrostimulation on Urinary Incontinence, pelvic floor muscle strength and impact on daily life of patients after Radical Prostatectomy: controlled experiment blind double randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-25	Hospital Federal dos Servidores do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-2h6sck	<NULL>	Patients with urinary incontinence after retropubic radical prostatectomy surgery; minimum time of one month and maximum of up to six months post surgery;cancer staging at low and intermediate risks	Symptoms of urinary tract infection; symptoms of lower urinary tract obstruction; anal fistula; metal implant in the body; transurethral resection of the prostate; previous radiotherapy; neurological diseases; non-execution of the proposed treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-9ryj5d	Speech therapy in patients with tuberculosis	Recruitment completed	Intervention	2019-08-07	<NULL>	<NULL>	2864	Speech therapy intervention in patients with tuberculosis in the upper airways and digestive tract	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Instituto Nacional de Infectologia	Instituto Nacional de Infectologia	https://ensaiosclinicos.gov.br/rg/RBR-9ryj5d	<NULL>	Patients who have confirmation of diagnosis of tuberculosis in the upper airways and digestive tract by one or more of the following methods: histopathology, direct examination, culture or PCR; are in attendance at the otorhinolaryngology clinic of INI / FIOCRUZ; consent to participate in the study by signing the consent form.	Patients younger than 18 years; have speech-language pathology at another institution; present chronic diseases that interfere with the otorhinolaryngological evaluation and / or speech-language therapy, such as head and neck neoplasias, stroke, Central Nervous System tumors, among others; patients with mental problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-529dpg	Effects of early mobilization on normal and cesarean birth	Data analysis completed	Intervention	2019-08-07	<NULL>	<NULL>	2865	Physiotherapy assistance in the immediate puerperium: a comparative study between normal birth and cesarean	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-529dpg	<NULL>	The study included women with 8 hours normal postpartum and 14 hours postpartum cesarean section, primiparous and multiparous, with medical authorization to perform physiotherapy, without any complications, such as hemorrhages and who accepted to be part of the study after the signature of the free and informed consent term	Were excluded from the study postpartum women less than 8 hours normal postpartum and 14 hours post-partum cesarean section, complications during delivery and postpartum, with anesthesia headache, bleeding, exacerbated pain in another body part, carriers of morbidities such as diabetes and hypertension who underwent curettage and tinnitus without medical authorization to receive physical therapy and who did not accept to be part of the study after reading the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-6n95jm	Weight-length ratio and body composition of Brazilian newborns: comparison with Intergrowth 21st	Recruitment completed	Observational	2019-08-07	<NULL>	<NULL>	2866	Weight-length ratio and body composition of term and late preterm newborns of a Brazilian cohort: comparison with Intergrowth 21st	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6n95jm	<NULL>	Babies born in Ribeirao Preto - SP in 2010, between 34+0 and 42+6 weeks of gestational age.	Incomplete data; congenital abnormalities; and twin birth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-7yqk5p	Effect of manual therapy in subjects with cardiovascular disease	Not yet recruiting	Intervention	2019-08-09	<NULL>	<NULL>	2867	Autonomic responses of coronary patients submitted to a protocol of osteopathic techniques: a crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-15	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	https://ensaiosclinicos.gov.br/rg/RBR-7yqk5p	<NULL>	Men with a diagnosis of ischemic coronary disease; above 45 years of age; who do not present a history of smoking or alcoholism; cardiovascular rehabilitation program followers who do not present a historical recruitment period for infections; do not present with unstable angina; controlled hypertension; without significant valvular disease; without uncontrolled metabolic disease	Volunteers will be excluded from the study when time series records of RR intervals show less than 95% of sinus beats; absence of attendance in at least one of the stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9yddrg	Use of Low Level Laser Therapy on Acupuncture points in patients with Chronic Tensional Headache in university students	Recruiting	Intervention	2019-08-12	<NULL>	<NULL>	2868	Analysis of the analgesic effect of Low Level Laser Therapy in Chronic Tension Headache using Acupuncture points and its positive effects on the quality of life of students of the State University of Western Paraná	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-9yddrg	<NULL>	Individuals with chronic tension headache; who are not undergoing any type of treatment; men and women; who are between 18 and 30 years of age; and who are Universidade Estadual do Oeste do Paraná scholars will be included	Individuals who use medication and who have any complications in relation to laser treatment at acupuncture points will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9mzjcb	Effect of Reiki  (integrative and complementary practice of laying hand) on anxiety  of nursing academics	Data analysis completed	Intervention	2019-08-13	<NULL>	<NULL>	2869	Effect of Reiki on anxiety level of nursing academics	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-19	Curso de Enfermagem do Instituto de Biotecnologia da Universidade Federal de Goiás - Regional Catalão	Universidade Federal de Goiás - Regional Catalão	https://ensaiosclinicos.gov.br/rg/RBR-9mzjcb	<NULL>	Academics over 18, of both sexes; not participating in other extension projects that involve integrative and complementary practices; which are compatible with the days of application of the reiki technique.	infectious and communicable diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-4w9vzg	The effects of manual therapy on market workers with undiagnosed chronic low back pain	Recruiting	Intervention	2019-08-13	<NULL>	<NULL>	2870	Effects of osteopathy on pediatric workers with non-specific chronic low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Amazonas	Universidade do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4w9vzg	<NULL>	Be a marketer; adult; voluntary; report having nonspecific low back pain persisted over a period of three months in a region of the back between the lower ribs and the gluteal fold.	Have a specific diagnosis of any spinal pathology or low back pain suggestive of secondary causes; the positive response in the Lasègue test for lumbar disc herniation; performing any type of drug treatment for low back pain; history of spinal fracture or surgery or infectious disease of the lumbar spine; waiver at any stage of the search either for reasons of force majeure or upon request.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-2qz78q	Effect of periodontal treatment on pcr and psa in patients with prostate cancer and periodontitis	Recruiting	Intervention	2019-08-14	<NULL>	<NULL>	2871	Effect of basic periodontal therapy of cpr and psa circulating levels in patients with prostate Cancer and Periodontitis	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-08	Luiza Silveira Camilotto	Luiza Silveira Camilotto	https://ensaiosclinicos.gov.br/rg/RBR-2qz78q	<NULL>	Male; age minimun 21 years; definitive diagnosis of prostate cancer determined by prostatic biopsy, performed preferably guided by transrectal ultrasonography; no professional dental prophylaxis performed in the last 3 months; minimun 06 teeth present; able and willing to understand the protocol and sign a consent form.	Positive history of periodontal treatment in the last six months; diabetes; history of myocardial infarction, stroke, or organ transplantation during the last 6 months; the need for antibiotic prophylaxis to perform routine dental procedures; use of anti-inflammatories for a long period of time, or any medicine that may interfere with periodontal aspects; smoking; patients who were unable to attend the appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-4897pw	Reduction of postoperative pain in knee ligament surgery: morphine versus femoral block	Data analysis completed	Intervention	2019-08-14	<NULL>	<NULL>	2872	Postoperative Analgesia: Intrathecal Morphine versus Femoral Block	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2013-12-03	Hospital Universitário Cajuru	Hospital Universitário Cajuru	https://ensaiosclinicos.gov.br/rg/RBR-4897pw	<NULL>	Patients submitted to elective surgery using the technique of anatomical reconstruction of the ACL with flexor tendons (semitendinous and gracilis); age between 18 and 65 years; classified as ASA I or II; score of at least 15 on the Glasgow Coma Scale; with the capacity to correctly answer the questionnaire applied by the researcher; who signed the informed consent term.	"Patients who did not meet the inclusion criteria; 
presence of other painful complaints that could confound the postoperative evaluation; sensory or motor neurological deficit of the lower limbs; infection at the puncture site; previous coagulopathies and / or INR 
less or equal 1.5; with another contraindication to the proposed technique; history of allergic reaction to some of the drugs used in the studies; patients with diabetes mellitus due to the increased probability of previous neuropathy due to the disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-72dqtm	Effects of mechanical vibration generated on a vibratory platform in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2019-08-14	<NULL>	<NULL>	2873	"Effects of mechanical vibration on oscillating/vibration platform  in patients with
Chronic obstructive pulmonary disease"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-04	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-72dqtm	<NULL>	Patients of both sexes, under follow-up at Serviço de Pneumologia do HUPE, diagnosed with COPD based on the criteria established by GOLD; patients with stable disease; with Forced Expiratory Volume in the 1st Second less than 50%; independent patients; signed by the Free and Informed Consent Form.	Patients with exacerbation for less than 3 months; patients with labyrinthitis; patients with osteoporosis reported; patients with other respiratory diseases; patients using pacemaker; patients with previous history of fractures or other orthopedic diseases submitted to surgeries with implantation of metallic material; patients with peripheral vascular disease or thromboembolism; patients smoker or severe alcoholic; patients with decompensated cardiovascular disease; patients with aneurysm; patients with previous vitreous hemorrhage; patients in malnutrition; postoperative patients; patients with neurological disease that causes &quot;fear&quot; of movements on the vibrating platform; severe or incapacitating clinical illness, at the discretion of the investigator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9sg585	The effect of laser and fluoride application in the treatment of dentin hypersensitivity	Data analysis completed	Intervention	2019-08-14	<NULL>	<NULL>	2874	Efficacy of laser and desensitizing agents in the treatment ofDentin Hypersensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9sg585	<NULL>	The sample will be composed of individuals diagnosed with dentin hypersensitivity greater than or equal to 2 in the verbal classification scale (RSV) after evaporative and tactile stimulation in at least one healthy tooth with gingival recession. Individuals above the age of 18 years, who agree to participate in the study will be included by signing the informed consent form (TCLE)	Individuals submitted to periodontal treatment in the last 30 days, individuals submitted to treatment for dentinal hypersensitivity in the last 30 days (treatment with fluoride, scraping and laser), pregnant and lactating; individuals with a carious, cavitary or restorative tooth .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-49v6j9	Profile of blood pressure and glycemic responses after interval exercise in older women attending a public health physical activity program	Recruitment completed	Intervention	2019-08-15	<NULL>	<NULL>	2875	Glucose and blood pressure responses after an interval exercise session in women with and without Hypertension	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-18	Universidade Federal do Espírito Santo	Prefeitura Municipal da Serra	https://ensaiosclinicos.gov.br/rg/RBR-49v6j9	<NULL>	Volunteers with and without arterial hypertension; participants in the exercise orientation program for at least 4 months; have a minimum age of 50 years and maximal of 70 years.	Volunteers with clinically uncontrolled systemic arterial hypertension with rest values above 160 by 105 mmHg; decompensated; cardiovascular diseases; neurological; cognitive and or respiratory disorders; cancer; presence of bone diseases; articular; difficulties in locomotion. Six participants were excluded because they did not meet the inclusion criteria; age greater than 70 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-736jwh	Easier and less expensive ovarian stimulation for women at high risk for ovarian hyperstimulation: a randomized controlled trial	Recruiting	Intervention	2019-08-15	<NULL>	<NULL>	2876	Friendly and cost-effective ovarian stimulation for women at high risk for ovarian hyperstimulation syndrome: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Laboratório de Ginecologia e Obstetricia do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-736jwh	<NULL>	Infertile women; risk of ovarian hyperstimulation syndrome;  between 18 and 38 years; antral follicle count between 20 and 39	Weight less than 60 Kg or greater than 80 kg; partner with spermogram showing total sperm count less than 1 million; do not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-36vn7j	Evaluation of scale ice on pain from dysmenorrhea in sedentary women	Recruiting	Intervention	2019-08-15	<NULL>	<NULL>	2877	Analgesic efficacy of cryotherapy in sedentary women with primary dysmenorrhea	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-36vn7j	<NULL>	Monthly condition of primary dysmenorrhea; have regular menstrual cycles; be between 18 and 30 years of age; be sedentary; agree to participate in the study	Use any other form of analgesia (such as analgesic drugs, analgesic electrical resources, physical exercises, among others); use anti-inflammatories; have secondary dysmenorrhea proven by medical examinations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-4xxz7j	Self-select intensity exercise selected for the elderly: implications of affect in community classrooms	Data analysis completed	Observational	2019-08-16	<NULL>	<NULL>	2878	Influence of functional capacity and health parameters on responses psychophysiology of the elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-30	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4xxz7j	<NULL>	Over 60 years old; at least 6 months of participation in regular physical exercises at the community center; medical authorization for physical exercise; do not have comorbidities that interfere with walking	Failure to comply with the research procedures; want for your participation in the study; feel uncomfortable in the study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-86pszd	Effect of Otosporin on the dental sensitivity of bleaching.	Recruitment completed	Intervention	2019-08-16	<NULL>	<NULL>	2879	Effect of Otosporin on dental sensitivity induced by bleaching.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-86pszd	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-8j8v74	Auriculotherapy for stress and anxiety treatment	Recruitment completed	Intervention	2019-08-19	<NULL>	<NULL>	2880	"Auriculotherapy with silicon tablets and placebo for stress, anxiety and improvement of quality of life:
Randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Instituto Terapia Integrada e Oriental	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-8j8v74	<NULL>	Volunteers with a score on the List of Stress Symptoms of 40 to 120 points corresponding to medium and high stress; Age between 18 and 60 years.	Volunteers who carry out treatment with some complementary practice simultaneously to the data collection; who use controlled-use medications, such as anxiolytics, antidepressants and herbal medicines.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-59552p	Comparison between two medications in pain control of dental infection: a clinical research in patients	Data analysis completed	Intervention	2019-08-19	<NULL>	<NULL>	2881	Comparison between isolated and associated with Codeine Paracetamol in pain con-trol of Acute Apical Abscess: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59552p	<NULL>	Patients were included in this research according to the following criteria: individuals 18 to 80 years old; diagnosis of acute apical abscess with pulpar necrosis origin; reporting mod-erate to severe pain at the first appointment (equal or superior to 40mm on VAS).	"They will be relieved to report being allergic to drugs not present, patients with a history of liver disease and infants.
Patients with chronic and / or anti-inflammatory opiates were also excluded, those who were or are users of substances such as crack, oxy, cocaine, marijuana and solvents. In addition, patients with cognitive (and therefore according to scales) as well as patients with cognitive impairment (and therefore from afar)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-7g7rq3	Analysis of cardiac and respiratory components after walking exercise in patients who suffered a stroke	Data analysis completed	Intervention	2019-08-20	<NULL>	<NULL>	2882	Cardiac Variability in Aerobic and Resistant Training of patients with Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7g7rq3	<NULL>	Patients between the ages of 40 and 65 years; verification of the stroke by image examination and medical report; injury time over one year; acceptance in participating in the intervention	Patients who could not walk or clinical conditions for walking; other neurological diseases; did not have medical clearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-7ydvpf	Use of laser and associated LEDs in people with non-specific chronic cervical pain	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2883	Analysis of the Cluster apparatus in the treatment of Chronic Neck Pain without specific etiology	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-17	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7ydvpf	<NULL>	Individuals aged 17 to 30; with non-specific chronic neck pain	Tendonitis; bursitis; disc herniation; TMJ (temporomandibular joint) trauma; osteoarthritis; tumors; cervical trauma;, infectious diseases; degenerative disc disease; pacemaker patients; pregnant women; patients with hypothyroidism; patients with heart problems; severe postural changes; perform treatment due to mental stress and anxiety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-6swqd2	Effects of Oncotherad Immunotherapy in the Treatment of Bacillus Calmette-Guérin (BCG)-Recurrent and Relapsed Non-Muscle Invasive Bladder Cancer	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2884	Effects of Oncotherad Intravesical Imunotherapy in the treatment of Bacillus Calmette-Guérin (BCG)-Refractory and Relapsed Non-Muscle Invasive Bladder Cancer patients	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2018-08-17	Universidade Estadual de Campinas (UNICAMP)	Hospital Municipal de Paulínia (HMP)	https://ensaiosclinicos.gov.br/rg/RBR-6swqd2	<NULL>	Patients, 18- to 95-year-old, with BCG-refractory and relapsed non-muscle invasive bladder cancer.  In addition, patients refractory to approved first and second line chemotherapy, who are at increased risk of progression to muscle invasive and / or metastatic disease, will be included. Acceptance of the Informed Consent Form (TCLE); multiple (greater than two lesions) and / or recurrent and / or large (greater than 3 cm) tumors TaG1-2; non-muscle invasive tumor (pT1); presence of carcinoma in situ (Cis); urothelial carcinoma of the bladder grade 3.	Patients with bladder lesion suspected of malignant neoplasm and who were not previously submitted to Transurethral Resection (TUR), ie, treatment-naive patients for the bladder tumor. Histology: adenocarcinoma, squamous cell carcinoma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-44rc4n	Effect of the use of Dexamethasone 4mg in the control of pain after the end of the treatment of the canal	Not yet recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2885	Post-operative pain control with the use of Dexamethasone4mg in patients submitted to endodontic treatment with foraminal enlargement	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-44rc4n	<NULL>	Patients in need of endodontic treatment. Both genders. ASA I and ASA II patients. Patients over 18 years of age.	Patients with a history of allergy to local anesthetics, corticosteroids and starch. Patients who used analgesics or anti-inflammatories 12 hours before the procedure. Patients were given antibiotics 48 hours before the procedure. Pregnant or lactating patients. Uncontrolled diabetic patients. Patients with open apex. Patients who needed antibiotic prophylaxis prior to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-6mvp9w	Evaluation of restorations using bulk fill ormocer based composite	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2886	Clinical evaluation of restorations in posterior teeth using bulk fill ormocer composite - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6mvp9w	<NULL>	Age between 18 and 70 years; presence of antagonist tooth; vital pulp and no painful sensation; no previous pulp caping; no previous report of sensitivity; istmus smaller than 2/3 of intercuspal distance; permanent teeth; good horal hygine and no periodontal disease; no sistemic disease; no removable prosthesis resting on the restored tooth.	Parafunctional habits; large caries lesions; pulpal exposure during the preparation; high risk of pulp exposure; pontaneous pain or after percussion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-8pcx5p	Evaluation of teeth restorations performed inside or outside the mouth	Recruiting	Intervention	2019-08-21	<NULL>	<NULL>	2887	Clinical evaluation of direct and indirect restorations of composite resin in posterior tooth clinical and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-8pcx5p	<NULL>	The inclusion criteria will be: patients with age between 18 and 80 year old; presence of adjacent tooth and antagonists to the tooth to be treated; pulp vitality and absence of painful symptomatology; tooth that were never submitted to pulp capping; absence of history of hypersensitivity; isthmus greater than 2/3 of the intercuspide distance; permanent teeth; adequate oral hygiene and absence of periodontal disease; absence of systemic diseases; absence of a removable partial denture that rests on the studied tooth or its antagonist.	The exclusion criteria will be: intense parafunctional habits; exposure to pulp during caries removal; cavities with imminent risk of pulpal exposure; spontaneous pain or sensitivity and percussion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-64rhd5	Effect of complementary therapies on anxiety, facial pain and sleep disorders.	Recruitment completed	Intervention	2019-08-21	<NULL>	<NULL>	2888	Effect of artistic and complementary therapies on the reduction of anxiety, TMD and sleep disturbances.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-64rhd5	<NULL>	Volunteers with one or more symptoms of anxiety, sleep disorder and TMD; both genders; non smokers; age between 20 and 45 years.	Volunteers outside the age group; total edentulous; users of total prostheses; smoking; history of alcohol or drug abuse; users of controlled drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-387ntq	Effects of Perineal Stretching in pregnant women who performed Exercises in the Perineal Region	Not yet recruiting	Intervention	2019-08-22	<NULL>	<NULL>	2889	Effects of Perineal Stretching in pregnant women performing Pelvic Floor Muscle Training: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-387ntq	<NULL>	Inclusion criteria will be considered: age over 18 years; gestational age of 33 weeks; primigravidae; physiological gestation; medical authorization to perform the intervention; pregnant women wishing to deliver vaginally; present medical certificate of release for participation in the research. For the pregnant women who will be part of the T Group, they will also have as inclusion criterion to have performed PFMT, during the gestational period, offered by the project approved by CEP / UFU, 3,054,152. For the pregnant women of the NT Group, the criterion is not to have performed PFMT.	The exclusion criteria will be: multiple gestation; presence of bone deformities; important muscular and nervous dysfunctions; presence of high gestational risk; unusual fetal position or risks that make vaginal delivery impossible (placenta previa); presence of risk of ascending infection; presence of vaginal bleeding; presence of cervical cancer; inability to contract the pelvic floor muscles; intolerance to vaginal palpation; presence of neurological and / or cognitive deficits that prevent the understanding of the procedures; use of prenatal pelvic floor preparation methods before being part of the study; being visibly under the influence of drugs or alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-65b5b3	Impact of Mindfulness Meditation Program on pain and quality of life in women with deep Endometriosis	Recruiting	Intervention	2019-08-23	<NULL>	<NULL>	2890	Impact of Mindfulness-Based Intervention on pain and quality of life in women with Deep Endometriosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Estadual do Rio de Janeiro	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-65b5b3	<NULL>	"Aged between 18 and 45 years; pelvic pain for more than 6 months, of intensity equal to or greater than 45 mm on the visual analog scale; 
Be under standard medical treatment. Have at least one infiltrative endometriosis nodule 2 cm or larger in size, as evidenced by magnetic resonance imaging or prior deep endometriosis surgery confirmed by histopathology."	Patients with a history of mental disorders that had a psychotic, dissociative, hallucinatory, or delusional component; suicidal ideation; an inability to attend each of the classes; inability to attend in the assessments; currently practicing meditation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-8mvbn4	Evaluation of the effect of respiratory exercises on inspiratory muscle strength and pulmonary function in patients with heart failure who participate in a cardiac rehabilitation program	Recruitment completed	Intervention	2019-08-23	<NULL>	<NULL>	2891	Evaluation of the effect of inspiratory muscle training on inspiratory muscle strength and pulmonary function in patients with heart failure submitted to a cardiac rehabilitation program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Maiqueli Arpini	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8mvbn4	<NULL>	Diagnosis of Heart Failure; optimized drug therapy; both sexes; being between the third and fourth phase of cardiac rehabilitation; participate assiduously in the cardiac rehabilitation program; sign the Informed Consent Form	Revascularization of the myocardium to less than three months; limiting orthopedic disease; being on steroid, hormonal and / or chemotherapy; history of exercise-induced asthma; miss three consecutive sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-6j2xs9	Virtual reality as distraction during exams of Urology	Recruitment completed	Intervention	2019-08-23	<NULL>	<NULL>	2892	Virtual reality during urological procedures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-6j2xs9	<NULL>	Patients older than 18 years attending the urology service for elective cystoscopy.	Patients who have a physical or mental disability that prevents them from using the technology (such as dementia or blindness).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-3s36zh	Rabies prevention: assessing the effect and cost of three (03) vaccination strategies	Not yet recruiting	Intervention	2019-08-23	<NULL>	<NULL>	2893	Rabies pre-exposure prophylaxis: Cost-effectiveness analysis of three (03) vaccination strategies	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-26	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3s36zh	<NULL>	Travelers; veterinarians; other professionals with occupational risk of exposure to rabies virus over the age of 18 years	Pre-or post-exposure rabies vaccine use; Severe allergy reported to any component of the vaccine; reported pregnancy; Disability to attend study visits; Abuse of illicit substances; Moderate to severe psychiatric illness; Immunosuppressive disease; Use of immunosuppressant medication for any reason within six (06) months prior to the study inclusion visit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-5ysgfv	Effect of coffee consumption on patients with liver fat	Recruiting	Intervention	2019-08-26	<NULL>	<NULL>	2894	Effect of coffee consumption on clinical variables, intestinal microbiota, oxidative stress and esteatose degree in patients with Non-Alcoholic Fatty Liver disease with or without polymorphism in gene PNPLA3	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-22	Instituto de Nutrição Josué de castro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-5ysgfv	<NULL>	Patients diagnosed with non-alcoholic fatty liver disease through Fibroscam; both genders; aged between 18 and 65 years.	"Patients with: another cause of hepatic steatosis (alcohol, virus, genetics) or advanced liver disease; chronic kidney disease
thyroid diseases; cushing&apos;s syndrome; cancer; pregnant or lactating women; history of upper gastrointestinal surgery; use of medications for weight loss; report of sensitivity to coffee; consumption of more than 3 cups of coffee per day."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-6tsjtz	Effect of the use of a Vibrating Instrument in the application of Dental Adhesive on the retention of restorations in Dental Lesions near the gingiva	Recruitment completed	Intervention	2019-08-26	<NULL>	<NULL>	2895	Effect of using a Vibrating Application Device compared to the Conventional Application of a Self-Etch Adhesive System in the retention of Composite Resin Restorations in patients with Non-Carious Cervical Lesions: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6tsjtz	<NULL>	Patients older than 18 years will be included; Presence of at least two non carious cervical lesion (NCCL) per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; NCCL with a maximum of 50% of enamel margin.	Pregnant women; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-878g2j	Use of Melatonin in the control of pain in face fractures	Recruitment completed	Intervention	2019-08-26	<NULL>	<NULL>	2896	Use of melatonin as an analgesic adjuvant in face fractures	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-878g2j	<NULL>	Patients between 18 and 60 years of ag; ASA I and II; who had a unilateral fracture of the zygomatic bone; with a trauma time of less than 15 days; and who showed indication of surgical treatment with at least 2 access points and fixation.	Patients who do not fit the planning of surgical and anesthetic techniques; have fractures in other regions; need coronal access; use other medications in the postoperative period; or present allergy to study medications will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-56xh4c	Efficacy and safety evaluation of new model of  intraocular lenses for cataract surgery.	Not yet recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2897	Efficiency and efficacy study of a new family of monofocal and multifocal intraocular lenses in the Cataract Personalized Solution Project.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital Evangélico de Belo Horizonte	Hospital Evangélico de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-56xh4c	<NULL>	"Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular or a combination) that was considered amenable to cataract extraction by the intracapsular facectomy method.
Adult patients 21 years of age or older.
Patients eligible for primary intraocular lens implantation.
Patients willing and able to perform clinical and follow-up examinations for a minimum of 1 year after cataract surgery.
Patients requiring intraocular lens implantation powers ranging from 10 to 30 diopters.
Patients with a visual potential of 20/40 or better in the eye indicated for intraocular lens implantation.
Patients with a corneal cylinder corrected for less than 1 diopter."	"Patients with any pathology of the anterior segment in which the intracapsular facectomy procedure with primary IOL implant is contraindicated (examples: keratoconus, dystrophy or corneal scars, anterior uveitis).
Patients with corneal inflammation or edema, including but not limited to: keratitis, keratoconjunctivitis and ceratouveitis.
Patients with uncontrolled glaucoma or glaucoma under treatment.
Patients with history of retinal detachment.
Patients with diabetic retinopathy (proliferative or non-proliferative).
Patients with congenital, metabolic, traumatic or complicated cataract.
Patients with marked microphthalmia or aniridia.
Patients who had previous ocular surgery of the proposed eye.
Patients who have already received other IOLs in the contralateral eye.
Irregular corneal astigmatism.
Amblyopia.
Clinically significant changes in the retinal / macular pigment epithelium.
Neovascularization of the iris, the camerular and retinal angle.
Severe recurrent inflammation of the anterior or posterior segment of unknown etiology.
Optical atrophy.
Patients with immunodeficiency (infectious, neoplastic or drug).
Patients on chronic systemic steroid use or immunosuppressive drugs.
Patients simultaneously participating in another clinical trial.
Patients with a strong dependence on intermediate vision, night vision, or specific occupational requirements (eg, commercial pilots and professional drivers)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-5rhp9j	Comparison between Lumbar Quadrant Blockade and Morphine made in Spinal Anesthesia for pain reduction after cesarean section	Recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2898	Comparison between Lumbar Quadrant Blockade and intrathecal Morphine for postoperative analgesia in Cesarean Section	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rhp9j	<NULL>	The inclusion criteria will be: ASA I and ASA II patients; with gestational age of at least 37 weeks; normal and single gestation,age between 18 and 60 years.	Os critérios de exclusão serão: inabilidade de compreender ou verbalizar a escala de avaliação da dor;  coagulopatias congênitas; anormalidades anatômicas e infecção localizada.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-6y6tyc	Parameterization of Respiratory Rate Alarms in Mechanical Ventilators before bathing in Invasive Mechanical Ventilation patients.	Recruitment completed	Intervention	2019-08-27	<NULL>	<NULL>	2899	Parameterization of mechanical ventilator alarms before body hygiene of patients on invasive mechanical ventilation.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-11	Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	https://ensaiosclinicos.gov.br/rg/RBR-6y6tyc	<NULL>	Adults between 18 and 100 years old; intubated or tracheostomized and on invasive mechanical ventilation in assisted or assisted-controlled mode at the time of bathing; with oncohematological disease as the basic diagnosis; patients with at least 4 uninterrupted hours of invasive mechanical ventilation before bathing and 4 uninterrupted hours of mechanical ventilation after bathing.	Patients using mechanical ventilator with misalignment or technical failure and patient with Acute Respiratory Distress Syndrome (ARDS).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-2t5j87	Anxiety in children undergoing dental treatment: a comparative study	Recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2900	Anxiety in children undergoing dental treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2t5j87	<NULL>	"Children attended at the pediatric outpatient clinic of the State University of Western Paraná.
Age between 8 and 9 years.
Children of both genders."	Children with physical disability and / or mental impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-46rtbv	Comparison between training of two virtual games in the thigh muscle and functional performance of the lower limb	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2901	Comparison between the effects of plyometric training and virtual training on electromyographic activity, kinematics, and functional performance of the trunk and lower limb	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-46rtbv	<NULL>	women aged 18 to 30 years; healthy	Women who had serious health problems; current or previous injuries in the lower limbs; signs of inflammation; pain and joint instability in the knee	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-3q6j7x	Acute effect of a Futsal Match on mood status, memory and attention in individuals with Chemical Dependence	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2902	Emotional states, Physical Exercise and cognitive functions in people with Alcohol and Drug use Disorder in the CAPS ad	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-26	Centro Universitário Católico Salesiano Auxilium	Centro Universitário Católico Salesiano Auxilium	https://ensaiosclinicos.gov.br/rg/RBR-3q6j7x	<NULL>	The inclusion criteria were: male gender; aged between 18 and 45 years; diagnosis of drug dependence, guided by the International Classification of Diseases (ICD-10) regardless of the time of treatment and dependence; no health restrictions and limitations identified by the PAR-Q questionnaire; and no impairment in mental state identified by the mini-mental state examination.	The exclusion criteria were: to present physical or mental limitations that prevented participation in the futsal match	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-785c8h	Comparison of Effectiveness in the Control Of Pain In Surgery Between Articain 4% With Adrenaline 1:100.000 and Lidocaina 2% With Adrenaline 1:100.000 In Inferior Third Molars Extractions: Randomized Clinical Study	Recruitment completed	Intervention	2019-08-27	<NULL>	<NULL>	2903	Comparison of effectiveness in the control of transoperatory pain between articaine 4% with adrenaline 1:100.000 and lidocaina 2% with adrenaline 1:100.000 in inferior third molars extractions: randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-08	Faculdade de Odontologia da Universidade Federal do Ceará campus Sobral	Faculdade de Odontologia da Universidade Federal do Ceará campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-785c8h	<NULL>	"Pacients with correct indication for third molars removal;both genders; with ages between 18 and 45 years; indication analyzed with imaginological exams ( panoramic or periapical radiographic); without any systemic diseases
without any periodontal disease; simetric mandibular third molars, with similar class and position;With 2/3 of root formation;pacients that agreed with the Consent Term"	Pacients with acute pericoronaritis and supuration; Bone lesions associated with mandibular third molars; Pacients with no agreement to the study; Pacients ASA III, IV,V and VI; Pacients with presence use of drugs that can may be affect the cicatricial process; Pacients with only one mandibular third molar; Pacients with unsimetric mandibular third molars	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-8svbbf	Whitening effect of mouthrinse and its safety: clinical study	Recruitment completed	Intervention	2019-08-27	<NULL>	<NULL>	2904	"The efficacy and safety of a whitening mouthrinse: randomized controlled
clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-25	Instituto de Ciência e Tecnologia UNESP	Instituto de Ciência e Tecnologia UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8svbbf	<NULL>	18 years old until 55 years old; good general health; abscence of gingival recession, clinical signs of noncarioues cervical lesions or active carie, periodontal disease, fluorosis or enamel deffects; do not use orthodontic devices or removable prothesis; present all the teeth; had not been submited to bleaching treatment previously; avaiability to return in appoitments; teeth color A2 or darker; good gingival condition - abscence of inflammation or irritation	Use of medicine for chronical disease or allergies; somokers; pregnant; participating in another study in the same time; presence of restorations on anterior teeth; use of products fluoride-based or dessensibilizing; tooth sensitivity; bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-3w3kmg	Study on the application of mobilization in the first 48 hours of hospitalization in comparison to the mobilization associated with muscle stimulation with electrical impulses in patients hospitalized in the ICU	Not yet recruiting	Intervention	2019-04-08	<NULL>	<NULL>	2905	Randomized trial about the application of an early mobilization protocol in comparison with early mobilization associated with neuromuscular electrical stimulation in critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-07	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3w3kmg	<NULL>	Patients admitted to the ICU for less than 48 hours; older than 18 years; both sexes; signature of the Free and Informed Consent Form is mandatory; exclusion criteria	Inability to walk without assistance before the acute illness that led to ICU admission; Previous neuromuscular disease that may delay or stop the ventilatory weaning (such as severe myasthenia, amyotrophic lateral sclerosis); Hip fracture, unstable cervical or pathological fracture (patient with block mobilization)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-4vrz2m	Evaluation of DNA damage in anesthesiologists	Data analysis completed	Observational	2015-03-25	<NULL>	<NULL>	2906	Damage assessment in the genetic material in anesthesiologists	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-05-07	Departamento de Anestesiologia	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4vrz2m	<NULL>	Anesthesiologists to compose the exposed group medical and clinical settings to compose the control group; healthy volunteers; both genders; non-smoking; age between 23 to 75 years.	Malignants diseases; infectious diseases; inflammatory diseases; alcohol consumption; use of tobacco; illicit drug use; use of medications; use of vitamin supplementation; radiation exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-954xsg	Monitoring of caries lesions among primary teeth after block with resin infiltrant	Data analysis completed	Intervention	2016-04-01	<NULL>	<NULL>	2907	Progression of early proximal caries lesions on primary molars after Sealing with Resin Infiltration: longitudinal follow up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-07	Faculdade de odontologia da Universidade Federal do Rio Grande do Sul	Jonas de Almeida Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-954xsg	<NULL>	Patients with at least 2 not clinically evident carious lesions that only involve proximal surface, in primary molars that presents radiolucence to the outer third of dentin.	Children who refuse to carry out longitudinal follow-up radiographs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-5szbt9	Effects of physical exercise in the treatment to stop smoking	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	2908	Aerobic training effectiveness in functional parameters in cessation of smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Universidade Estadual Paulista - FCT/UNESP	Universidade Estadual Paulista - FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5szbt9	<NULL>	Eligible participants should meet the following inclusion criteria: smoking at least 10 cigarettes / day; age between 18 and 60 years; clinically stable individuals with no change in medications for at least 30 days; desire to stop smoking.	Smokers who have pre-existing chronic cardiorespiratory diseases (arrhythmias, uncontrolled hypertension, chronic cough, chronic bronchitis, pulmonary emphysema or FEV1 / FVC &lt;70%); individuals with pathological conditions that prevent the performance of physical exercise (orthopedic or neurological diseases); individuals with another pathological condition that may influence the systemic inflammatory process (metabolic or rheumatic diseases); use of nicotine replacement drugs and / or antidepressants as an aid in smoking cessation; Alcohol abuse; pregnant women current or intending to become pregnant during the exercise protocol; and participants from another systematic exercise program for at least 20 minutes a day, three days a week for three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-6gf6dx	Study of occupational exposure in anesthesiologists	Data analysis completed	Observational	2017-09-12	<NULL>	<NULL>	2909	"Evaluation of redox status, inflammatory response, telomeres and gene expression in 
anesthesiologists"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6gf6dx	<NULL>	Anesthesiologists to compose the exposed group medical and clinical settings to compose the control group; healthy volunteers; both genders; non-smoking; age between 23 to 75 years.	Malignants diseases; infectious diseases; inflammatory diseases; alcohol consumption; use of tobacco; illicit drug use; use of medications; use of vitamin supplementation; radiation exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-76w7cj	Effect of using a new Instrument XP-Endo Finisher in Root Canal Treatment	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	2910	Effect of the XP-endo Finisher Instrument on the reduction of Periapical Lesions in posterior teeth: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-76w7cj	<NULL>	Any individual presenting with posterior teeth with a clinical picture of pulp necrosis and radiographic evidence of apical periodontitis, presenting lesions greater than 2 mm in diameter;Agree to participate and sign the informed consent form	"Teeth with great coronary destruction, requiring prosthetic rehabilitation; Present any pre-existing general and / or oral clinical condition that puts the individual at risk during the study;
Being pregnant or breastfeeding; Patient with generalized periodontal disease or affecting the tooth that needs endodontic treatment; Allergic reaction to chemicals used in endodontic treatment;Teeth that do not present complete root formation - incomplete rhizogenesis; Teeth that present radiographic evidence of internal or external root resorption; Teeth whose root canal is calcified; Teeth submitted to previous endodontic treatment; History of antibiotic use prior to treatment; or need for antibiotic prophylaxis (eg bacterial endocarditis); Teeth that present vital pulp tissue, even if radiographically there is presence of radiolucent image associated with the periápice; Teeth that, during the endodontic treatment, show signs of root fracture; When, during the endodontic procedure, accidents and complications occur, specifically root perforations and instrument separation within the SCR; Patients who do not return to reassessment appointments"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-4qdx3v	Different materials for the technique of Atraumatic Restoration in deciduous teeth of children, a clinical investigation with 3 years of follow-up	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2911	Randomized double blind clinical trial using different materials in deciduous teeth of children by the ART technique: two years of follow-up	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4qdx3v	<NULL>	Healthy Volunteer Children; both genders; duly enrolled in municipal schools; with an acceptable oral hygiene level; with a minimum of 4 years and a maximum of 9 years	Children who are missing on scheduled restorations day; those responsible do not sign the Free and Informed Consent Form; children who do not accept by bad behavior the oral examination or the realization of the restorations; teeth with very deep carious lesions; fistulated teeth; with such spontaneous pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-4rjgc3	Evaluation of Blood Pressure, Heart Rate and Glycemia in Patients submitted to different types of Interval Training	Recruiting	Intervention	2018-08-29	<NULL>	<NULL>	2912	Evaluation of Cardiorespiratory and Metabolic Variables in Patients submitted to different types of Interval Training: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4rjgc3	<NULL>	The following inclusion criteria will be adopted: women; between 40 and 65 years; arterial hypertension; diabetes mellitus; without experience with high intensity interval training.	Will be exclued from the study who present: feverish or self-reported infectious disease; self-reported smoking; chronic disease, myocardial revascularization surgery; arrhythmias and extrasystoles frequent in resting conditions or triggered during clinical stress test; unstable angina; obstructive pulmonary disease; neoplasia; renal insufficiency; sequelae of stroke; osteomioarticular changes; hepatic insufficiency and uncontrolled hypothyroidism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4gmvpg	Translation of the Expected Consequences of Hearing Aid Ownership questionnaire into Portuguese	Data analysis completed	Observational	2019-08-28	<NULL>	<NULL>	2913	Cultural adaptation of the Expected Consequences of Hearing aid Ownership (ECHO) questionnaire for Brazilian Portuguese	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-27	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gmvpg	<NULL>	Signature of Consent Form and Free Clarified; diagnosis of hearing loss; good general health, so that they can be presented to the clinic for care; the same or more than 18 years; comprehension capacity to respond to the questionnaire.	Refusal to reply to the questionnaire; did not have comprehension capacity to answer the questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9ttmzj	Effect of Respiratory Muscular Training of Mucopolysaccharidosis patients on movements and respiratory volumes, functionality and quality of life	Recruiting	Intervention	2019-08-28	<NULL>	<NULL>	2914	Effectiveness of Respiratory Muscle Training of patients with Mucopolissacaridose in toracoabdominal kinematics, respiratory function and mechanics, functionality and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-25	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9ttmzj	<NULL>	Patients with a diagnosis of Mucopolysaccharidosis; confirmed by enzymatic dosing by blood test; from 6 to 60 years old; registered at the Breno Bloide Institute for rare diseases in the state of Pernambuco; Brazil; and who are over six years of age who agree to be part of the research and who sign the terms	Patients younger than six years of age and; over 60 years old; those who do not understand the controls for performing the evaluations will be excluded from the study; In relation to the specific evaluation tests; only those that are contraindicated for performing the specific test will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-2j5294	Effects of beer on recovery of cardiac activity after aerobic exercise	Recruitment completed	Intervention	2019-08-28	<NULL>	<NULL>	2915	Effects of beer on autonomic heart rate control recovery following submaximal aerobic exercise	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-07	Faculdade de Juazeiro do Norte	Faculdade de Juazeiro do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2j5294	<NULL>	Eutrophic; age 18 to 40 years	Smoking; cardiorespiratory and neurological disorders; musculoskeletal injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8bh5k7	Immediate effects of Acupuncture on strength and muscle pain	Data analysis completed	Intervention	2019-08-29	<NULL>	<NULL>	2916	Effects of the Acupuncture application on the delayed onset muscle soreness (DOMS) and in the muscle contraction capacity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8bh5k7	<NULL>	"Participants should have at least two years of resistance training experience, in which the biceps curl exercise was part of their training routines.  Participants were considered as physically active, i.e., exercised from two to three times per week using light to moderate intensities,  before the commencement of the experiment.
Participants above 18 years or older"	Participants with upper limb articular and muscular conditions that could affect muscle strength, e.g., tendinitis, bursitis, recent fractures, etc., hypertension or hypotension and or under the effect of drugs such as corticoids, psychotropic, anti-inflammatory, and analgesic, were excluded from the study.  In addition, participants with an excessive fear of needles were not included. Aged over 40 years-old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-3j2xxq	A phase III double blind placebo controlled  study of MEDI4736 for improving survival in patients facing completely ressected Non-Small Cell Lung Cancer	Recruiting	Intervention	2019-08-29	<NULL>	<NULL>	2917	A phase III prospective double blind placebo controlled randomized study of adjuvant MEDI4736 in completely ressected Non-Small Cell Lung Cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-02	Canadian Cancer Trials Group	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-3j2xxq	<NULL>	Histologically confirmed diagnosis of primary non-small cell carcinoma of the lung (NSCLC) according to WHO Classification of Tumours. Patients with large-cell neuroendocrine carcinomas are not eligible. Patients must consent to release of an adequate histological specimen for this protocol, and the tissue blocks must be available for submission after registration. Failure to provide tissue blocks for PD-L1 expression assessment will render the patient ineligible; patients must be classified post-operatively as Stage IB (&gt; 4cm in the longest diameter), II or IIIA based on pathologic criteria; surgery and previous therapy for NSCLC: a pre-surgical PET scan of the thorax and a MRI or CT scan of the brain is considered standard of care and thus must be done prior to surgery. Patients in whom this was not done prior to surgery may still be enrolled providing that appropriate imaging is performed prior to randomization; b. complete surgical resection of the primary NSCLC is also mandatory. All gross disease must have been removed at the end of surgery. All surgical margins of resection must be negative for tumour; c. lymph node mapping is defined by The International Association for the Study of Lung Cancer (IASLC) lymph node map. The nodal tissue should be labelled according to the recommendations of the American Thoracic Society. Accordingly, it is recommended that a minimum of 3 (three) lobe specific mediastinal nodal stations (N2), one of which should include station 7, and at least one N1 station - inclusive of the ones removed with the pulmonary specimen have been sampled at the end of the procedure; d. if preoperative CT and/or PET are suspicious for mediastinal nodal involvement, it is recommended that invasive mediastinal staging with mediastinoscopy or EBUS-TBNA be performed. Station 5 or 6 lymph nodes may be accessed by anterior mediastinotomy or VATS. This may also occur at the time of the surgical resection. If invasive staging shows disease in regional lymph nodes, they must be surgically removed. It is recommended that complete mediastinal lymph node dissection be undertaken for stage IIIA tumours; e. surgery may consist of lobectomy, sleeve resection, bilobectomy or pneumonectomy as determined by the attending surgeon based on the intraoperative findings. Patients who have had only segmentectomies or wedge resections are not eligible for this study. Note: Where a resection has been extended by means of a wedge resection of an adjacent lobe in order to ensure complete resection of a tumour at or crossing a fissure between lobes, if the margins are clear this is acceptable. Where the resection of a second tumour nodule, even where not considered to be a co-primary, is undertaken by means of a wedge resection of a separate lobe then the patient is not eligible; prior systemic therapy: a. pre-operative (neo-adjuvant) platinum based or other chemotherapy is not permissible; b. patients may have received prior post-operative platinum based chemotherapy as per standard of care. Patients who discontinue chemotherapy for toxicity prior to completion of all planned chemotherapy are eligible; c. if adjuvant platinum-based chemotherapy is given, it is strongly recommended that this be started within 8 weeks of surgery; d. patients must have recovered from all acute, reversible toxic effects from chemotherapy (excluding alopecia); e. patients who have not received adjuvant chemotherapy, and meet all other eligibility criteria, may be eligible under the following circumstances: all patients who are eligible for adjuvant chemotherapy must be offered adjuvant chemotherapy prior to any discussion about this trial and that must be documented; the patient has declined adjuvant chemotherapy, and in the opinion of the investigator, this is the patient’s final decision after receiving appropriate information and adequate time to make the decision; if in the view of the investigator, adjuvant chemotherapy is contraindicated due to an underlying intercurrent illness/ laboratory abnormality, which is not considered reversible within a reasonable timeframe for the patient to be eligible for adjuvant therapy, which must be documented; no prior anticancer therapy for treatment of NSCLC other than standard post-operative adjuvant chemotherapy is permissible; radiation: patients with N2 disease only who receive adjuvant post-operative radiation therapy are eligible provided they meet the protocol specified timing criteria for surgery, adjuvant chemotherapy and randomization. Pre-operative radiation therapy is not permissible; timing between surgery and adjuvant chemotherapy and randomization: surgery: a. a minimum of 3 weeks must have elapsed between NSCLC surgery and randomization. A minimum of 4 weeks must have elapsed for other types of surgery. Complete post-operative wound healing must have occurred following any surgery; b. no more than 10 weeks may have elapsed between surgery and randomization for patients who have not received adjuvant chemotherapy; for patients after adjuvant chemotherapy: for patients who received post-operative adjuvant platinum-based chemotherapy, a minimum of 2 weeks must have elapsed (but no more than 10 weeks) from the last administered dose of chemotherapy to the date of randomization; for patients after post-operative adjuvant radiation therapy: for patients who received post-operative adjuvant radiation therapy, the patient must meet the protocol specified timing criteria for surgery, adjuvant chemotherapy and randomization. The post-operative radiation therapy must be completed prior to randomization; the patient must have an ECOG performance status of 0, 1; hematology (done within 14 days prior to randomization and with values within the ranges specified in the protocol): if anemic, patients should be asymptomatic and should not be decompensated. Transfusions are permissible; biochemistry (done within 14 days prior to randomization and with values within the ranges specified in the protocol); patient able and willing to complete the quality of life, economics and other questionnaires. The baseline assessment must already have been completed within required timelines prior to randomization. Inability (illiteracy, loss of sight, or other equivalent reason) to complete the questionnaires will not make the patient ineligible for the study; patients must be accessible for treatment and follow-up; age of at least 18 years	Patients with a history of other malignancies, except adequately treated non-melanoma skin cancer, curatively treated in-situ cancer, or other malignancies curatively treated with no evidence of disease for &gt; 5 years following the end of treatment and which, in the opinion of the treating physician, do not have a substantial risk of recurrence of the prior malignancy; a combination of small cell and non-small cell lung cancer, pulmonary carcinoid tumour or large-cell neuroendocrine carcinoma (LCNEC); history of autoimmune disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener’s granulomatosis, Sjögren’s syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis. Note: patients with Grave’s disease and/or psoriasis not requiring systemic therapy within the last two years from randomization and patients with hypothyroidism (e.g. following Hashimoto syndrome) stable on hormone replacement are not excluded; history of primary immunodeficiency, history of allogenic organ transplant, use of immunosuppressive agents within 28 days of randomization* or a prior history of severe (grade 3 or 4) immune mediated toxicity from other immune therapy (* note: intranasal/inhaled corticosteroids or systemic steroids that do not to exceed 10 mg/day of prednisone or equivalent dose of an alternative corticosteroid are permissible); live attenuated vaccination administered within 30 days prior to randomization; history of hypersensitivity to MEDI4736 or any excipient; patients who have experienced untreated and/or uncontrolled cardiovascular conditions and/or have symptomatic cardiac dysfunction (unstable angina, congestive heart failure, myocardial infarction within the previous year or cardiac ventricular arrhythmias requiring medication, history of 2nd or 3rd degree atrioventricular conduction defects). Patients with a significant cardiac history, even if controlled, must have a LVEF &gt; 50% within 12 weeks prior to randomization; concurrent treatment with other investigational drugs or anti-cancer therapy; patients with active or uncontrolled infections or with serious illnesses or medical conditions which would not permit the patient to be managed according to the protocol [this includes but is not limited to: known clinical diagnosis of tuberculosis; known active hepatitis B infection (positive HBV surface antigen (HBsAg)). Patients with a past or resolved hepatitis B infection (defined as presence of hepatitis B core antibody (anti-HBc) and absence of HBSAg) are eligible; known active hepatitis C infection. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RA; known human immunodeficiency virus infection (positive HIV antibodies); known pneumonitis or pulmonary fibrosis with clinically significant impairment of pulmonary function]; pregnant or lactating women. Women of childbearing potential must have a urine pregnancy test proven negative within 14 days prior to randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-6369bw	Treatment before and after shoulder muscle injury surgery	Data analysis completed	Intervention	2019-08-30	<NULL>	<NULL>	2918	Rehabilitation pre-and post-operative of Rotator Cuff injury	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Ciências Médicas e da Saude de Juiz de Fora - Suprema	Faculdade de Ciências Médicas e da Saude de Juiz de Fora - Suprema	https://ensaiosclinicos.gov.br/rg/RBR-6369bw	<NULL>	Individuals a history of shoulder pain after trauma and diagnosed with rotator cuff injury by an orthopedic shoulder surgeon through clinical examination and confirmed by magnetic resonance imaging	Fractures or pre-existing shoulder conditions such as adhesive capsulitis; joint instability; and labral lesion were excluded; as were those who were absent at any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-59hy2k	Metabolic and inflammatory effects of decreasing preoperative fasting time in preschool children undergoing inguinal hernia repair	Data analysis completed	Intervention	2019-08-30	<NULL>	<NULL>	2919	Metabolic and inflammatory results of reducing preoperative fasting time in preschool children undergoing inguinal hernia repair	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-26	Santa Casa de Misericórdia de Cuiabá	Santa Casa de Misericórdia de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-59hy2k	<NULL>	The enrolled patients were children aged from 2 to 6 years; who were to be treated at the hospital Santa Casa of Misericórdia;  presented an anesthetic risk classified as ASA I or II (healthy patient or small morbidity); and were to be operated for  inguinal elective herniorrhaphy (small and moderate inguinal hernias).	Where excluded patients with other concomitant surgical diagnoses detected during hospitalization; as well as patients with giant inguinal hernias; those whose surgeries were cancelled due to respiratory symptoms; patients whose parents declined to participate in the study; with failure during collection of blood samples; who did not correctly followed the perioperative protocol delineated by the research where also excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-3z39v3	Functional training and pilates in individuals with Parkinson&apos;s disease	Recruiting	Intervention	2019-08-30	<NULL>	<NULL>	2920	Effects of functional training and mat pilates in elderly patients with Parkinson&apos;s disease: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Uberlândia	Faculdade de Educação Física da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3z39v3	<NULL>	Individuals with Parkinson&apos;s disease between 60 and 80 years old, members of a extension project; classified in stages I and II according to the Hoehn Yahr Scale; without cognitive alterations; medical release for physical activity	Cardiovascular or respiratory alterations; fractures or soft tissue injuries in the last six months that would disrupt the performance of the activities and the accomplishment of other therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-658n6w	High dose of therapeutic ultrasound in the treatment of patellar tendinopathy	Recruiting	Intervention	2018-05-18	<NULL>	<NULL>	2921	High-energy dose of therapeutic ultrasound in the treatment of patellar tendinopathy: a controlled, randomized and blinded, clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-658n6w	<NULL>	Volunteers of both sexes; with diagnosis of unilateral or bilateral patellar tendinopathy; aged between 18 and 40 years-old; with localized pain at the inferior patellar pole/superior aspect of patellar tendon when perform single leg decline squat, jumping, landing, running, abruptly changing direction and with a score of less than 80 on the Victorian Institute of Sports Assessment - Patella (VISA-P) questionnaire.	Participants will be excluded if they present a history of nervous and/or musculoskeletal injuries in the low back spine and/or lower limbs in the last 6 months, signs and/or symptoms of other diseases and/or another disorders affecting the knees, including systemic and rheumatic diseases and/or pre-existing dysfunctions (clinically evaluated and detected), previous history of knee or patellar tendon surgery, use of intra-articular medications in the knee in the last 6 months, or pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-2x4pv6	Mindfulness and quality of life of mental health professionals	Recruitment completed	Intervention	2018-10-08	<NULL>	<NULL>	2922	Effects of a mindfulness based intervention in the quality of life of mental health professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-25	Faculdade de Medicina de Botucatu (FMB-UNESP)	Faculdade de Medicina de Botucatu (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-2x4pv6	<NULL>	Mental health professionals working on direct patient assistance on brazilian public mental health services; healthy volunteers.	Accutely ill professionals; Professionals who were absent in more than 4 meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8nkhhk	Safety and efficacy of intramuscular vaccination without aspiration before injection: a randomized clinical trial	Not yet recruiting	Intervention	2019-09-03	<NULL>	<NULL>	2923	Safety and immunogenicity in intramuscular injection of vaccine without aspiration prior to injection: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-23	Universidade Federal de Alagoas - UFAL	Hospital Universitário Professor Alberto Antunes - HUPAA	https://ensaiosclinicos.gov.br/rg/RBR-8nkhhk	<NULL>	Healthy volunteers; both genders; age between 18 and 59 years.	Individuals with immunosuppressive disease or treatment; acute febrile illness; made use anti-inflammatory drug, analgesic or antipyretic 24 hours before vaccination; history of allergic reaction to any of the components of the Hepatitis A vaccine; pregnant women; history of hepatitis A disease; history of vaccination against Hepatitis A; previous titration of antibodies against the Hepatitis A virus (anti-HAV IgG); persons undergoing blood transfusion or use of blood products in the last 28 days; persons who are unable to respond on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-7zwzs3	Analysis of Cinnamaldehyde to be used in the Treatment of Fungal Infection due to the use of dental prostheses	Not yet recruiting	Observational	2019-09-03	<NULL>	<NULL>	2924	Efficacy and Safety of Cinnamaldehyde in the Treatment of Buccal Candidiasis associated with the use of dental prostheses: Clinical Trial, Randomized, Controlled and Blind	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7zwzs3	<NULL>	"Fase I: The study will include healthy individuals and users of upper removable total prosthesis, belonging to the age group from 40 to 70 years.
In order for there to be no confusion of signs and symptoms relevant to possible adverse effects of the test product with signs and symptoms of disease, healthy subjects were selected as defined by the Phase I clinical trial definition.
fase II: Individuals belonging to the age group from 40 to 70 years old, with oral candidiasis and dental prosthesis user, with a signed and signed Free and Informed Consent Term."	Fases I e II: Individuals undergoing topical and / or systemic antimicrobial treatment and who have a sensitivity reaction to cinnamaldehyde, cinnamon or Miconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9d5cr6	Effect of respiratory exercise in children with leukemia under treatment without heart control.	Recruitment completed	Intervention	2019-09-03	<NULL>	<NULL>	2925	Effects of Respiratory Kinesiotherapy in children with Leukemia undergoing treatment on Cardiac Autonomy.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-02-19	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9d5cr6	<NULL>	Children and adolescents on leukemia treatment; both genders; age range 4 - 15 years old.	Volunteers with lung, neurological, or drug-related illnesses in addition to those used to treat leukemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9m4bh7	Evaluation of pain, edema and trismus; oxidative stress markers and quality of life in mandibular third molar surgeries under different preemptive analgesia protocols: randomized clinical trial.	Recruiting	Intervention	2019-09-04	<NULL>	<NULL>	2926	Evaluation of clinical parameters, oxidative stress markers, and quality of life in mandibular third molar surgeries under different preemptive analgesia protocols: randomized, factorial, clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9m4bh7	<NULL>	Healthy individuals (American Society of Anesthesiologists - ASA I) of both genders; aged 18-35 years; who are required to remove the lower third molars; will be invited to participate in this study. In addition, the following inclusion criteria will also be adopted: (1) third unerupted mandibular molars; (2) third molars that present, in panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer.	Will be excluded volunteers who meet at least one of the following criteria: history of photosensitivity; smokers; pregnant or lactating; users of medications that interact with drugs used in this study; patients with orthodontic bands in mandibular second molars; confirmed history of NSAID allergy; signs of any pre-operative inflammatory or infectious condition; systemic diseases; neurological disorders. In addition, the volunteer who has used any NSAID within a period of up to 21 days prior to the surgical procedure will also be excluded from the study because of the possibility of residual residual anti-inflammatory effects, which may influence the outcomes of the present study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-3n9wxw	The effect of Platelet Rich- plasma on facial aging	Data analysis completed	Intervention	2019-09-04	<NULL>	<NULL>	2927	The use of Platelet Rich Plasma in the treatment of skin aging	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-18	Centro de Hematologia e Hemoterapia - HEMOCENTRO	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3n9wxw	<NULL>	Healthy volunteers; women; non-smokers; age between 40 and 65 years; Glogau grade II or III photoaging; Fitzpatrick phototype I-IV	Volunteers smoking; history of alcohol or drug abuse; pregnant or in the puerperium; facial aesthetics with absorbent material (hyaluronic acid), laser use in the last year, use of retinoic acid, application of botox or filling and surgical procedures; patients with a history of photosensitivity and of keloid or hypertrophic scar; patients with lesions of infected or inflamed skin on the face in the last year; underlying diseases such as uncontrolled hypertension, liver disease, renal, haematological, inflammatory, rheumatologic, diabetes; patients who have or have had dysplasias;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-986tpd	Influence of calcium and / or vitamin D supplementation in patients with Polycystic Ovarian Syndrome.	Recruiting	Intervention	2019-09-05	<NULL>	<NULL>	2928	Metabolomic analysis in Polycystic Ovarian Syndrome and its application in a randomized clinical trial with calcium and vitamin D supplementation.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-986tpd	<NULL>	Clinical trial: women with medical diagnosis of Polycystic Ovarian Syndrome; age between 18 and 40 years.	Type II diabetes; autoimmune disease; adrenal, renal and hepatic diseases; thyroid disorders; cancer or tumors; acute inflammatory disease; hyperprolactinemia; hypogonadism and pregnancy. Volunteers treated with the following medications will also be excluded: steroid and non-steroidal anti-inflammatories; isotretinoin; cyclosporin; antiretrovirals; insulin; metformin and oral contraceptives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9pkxn2	Active Life: discovering healthy paths	Data analysis completed	Intervention	2019-09-05	<NULL>	<NULL>	2929	Active Life: discovering healthy paths	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-16	Universidade Federal de Santa Catarina	Illinois University of Urban-Champaign	https://ensaiosclinicos.gov.br/rg/RBR-9pkxn2	<NULL>	"Study participants were men and women aged 60 or older;
no severe physical and/or mental health impairments;
not participate in physical activity programs in the past six months."	"Heart attack and/or stroke in the past six months;
cancer diagnosis in the past six months;
other severe medical conditions in the past six months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-44bjjf	Does Ketamine in anesthesia produces superior, inferior or similar analgesia compared to Morphine in uterus removal surgery	Data analysis completed	Intervention	2019-09-09	<NULL>	<NULL>	2930	Does intrathecal Ketamine produces superior, inferior or similar analgesia compared to Morphine in Abdominal Hysterectomy surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Hospital São José do Avaí	Santa Casa de Belo Horizonte - Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-44bjjf	<NULL>	The study enrolled women; over 18 years old; scheduled for elective abdominal hysterectomy at Hospital São José do Avaí; ASA I-III patients.	patients unlikely to be fully cooperative during the study; allergy to dipyrone/ketoprofen; non-indication for spinal anesthesia; cognitive impairment; severe renal impairment; lack of consent to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-2y2zgy	Effects of an educational activity on adolescent knowledge, attitude and practice regarding cervical Cancer prevention	Recruitment completed	Intervention	2019-09-10	<NULL>	<NULL>	2931	Effects of an educational intervention on adolescent knowledge, attitude and practice regarding cervical Cancer prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Ceará - UFC	Universidade Federal do Ceará - UFC	https://ensaiosclinicos.gov.br/rg/RBR-2y2zgy	<NULL>	Adolescent; women; age between 13 and 19 years old; regularly enrolled in school	Have a disability that compromises the responses of the adolescents during the research and the involvement of the educational activity, as well as participation in social intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-44g6qp	Benefits of different ways of practicing bodybuilding	Recruitment completed	Intervention	2019-08-29	<NULL>	<NULL>	2932	"Acute and chronic adaptations of different resistance training protocols and
concurrent"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-15	Faculdade de Nutrição-Universidade Federal de Goias	Faculdade de Nutrição-Universidade Federal de Goias	https://ensaiosclinicos.gov.br/rg/RBR-44g6qp	<NULL>	Individual from 60 to 85 years old; both sexes; untrained	Acute or terminal musculoskeletal disease; cardiovascular disease; unstable cardiovascular condition; recent history of acute myocardial infarction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-89rvgg	Axillary web syndrome -  Physical therapy treatment after Breast cancer surgery.	Recruiting	Intervention	2019-09-11	<NULL>	<NULL>	2933	Axillary web syndrome - Clinical trial of physiotherapeutic conduct after Breast cancer surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-21	Patricia Vieira Guedes Figueira	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89rvgg	<NULL>	Women from 18 years of age. Invasive or non-invasive breast cancer. Breast cancer surgery (mastectomy, quadrantectomy, lumpectomy), with some axillary procedure: Sentinel Lymph Node Biopsy (SLNB) or Axillary Lymph Node Dissection (DLNA). Presence of axillary web syndrome in the evaluation. Voluntary consent.	Previous surgeries in shoulder, breast ou axilla.Anterior orthopedic or rheumatic shoulder changes, such as frozen shoulder, cuff injury, impact syndrome, arthritis, fractures, and arthritis. Immediate reconstruction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-96j9xn	Effect of exercise on body fat, blood glucose, blood pressure and body damage in type 2 diabetic	Data analysis completed	Intervention	2019-09-11	<NULL>	<NULL>	2934	Effect of a training program on body composition, glycemic profile, blood pressure, inflammatory process and oxidative stress in type 2 diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-96j9xn	<NULL>	Medical diagnosis of type 2 diabetes at least 12 mouths; 40 to 65 years; 25 to 35 kg/m² BMI; be sedentary or insufficiently active in IPAQ-vc (MATSUDO et al., 2001); regular drug hypoglycemic treatment; do not use insulin and anti-inflammatory drugs.	Changes in drug hypoglycemic treatment; begin chronic use of anti-inflammatory drugs; injuries in muscles; bones and/or tendon; significant changes in nutritional behavior or physical activity; as well as miss 25% of training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-27cqn5	Use of transdermal Testosterone in women with decreased sexual desire and tendency for aggressiveness: a double blind randomized clinical trial	Recruiting	Intervention	2019-09-11	<NULL>	<NULL>	2935	Use of transdermal Testosterone Nanoemulsion in women with Hypoactive sexual desire and tendency for aggressiveness: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-05	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-27cqn5	<NULL>	Women between 18 and 45 years old with regular menstrual cycles; decreased sexual desire; sexual activity present with at least one sexual event per month with actual partner; be in good general health; use of an effective contraceptive method; women over 40 years old should have a clinically acceptable mammogram in the last 2 years;	Sexual dysfunction caused by another medical condition; body mass index (BMI) below 18 kg / m2 or above 35 kg / m2; undiagnosed genital bleeding; androgen therapy in the last 6 months; antiandrogen therapy for acne or hirsutism in the last 5 years; moderate or severe acne, hirsutism, or androgenetic alopecia; participant with any hyperandrogenic syndrome; any clinical illness or severe depression, active cancer, or treatment of malignancy in the last six months; pregnancy or breastfeeding; do not come to our center for follow-up study visits;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9zrx3d	The influence of simultaneous physical exercise training associated with attention and memory tasks on the changes related to aging	Recruitment completed	Intervention	2019-09-12	<NULL>	<NULL>	2936	Aging, cognition, physical exercises and cognitive stimulation as preventive and therapeutic strategies for cognitive decline associated with age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Naina Yuki Vieira Jardim	Natáli Valim Oliver Bento-Torres	https://ensaiosclinicos.gov.br/rg/RBR-9zrx3d	<NULL>	Performance within the normality standards in the mini mental state examination. Absence of a history of cranioencephalic trauma. Failure to history of stroke. Absence of history of depression. It is necessary to be without exercising regularly and systematically for at least six months.	Age less than sixty years. Score below the normality standards in the mini mental state examination.History of traumatic brain injury. History of stroke. History of depression. Regular practice of physical exercise in the last 6 months. Visual acuity above twenty by thirty according to the Snellen test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-2gvcbq	Surgical treatment of vaginal wall prolapse using the anchoring system or traditional technique	Recruitment completed	Intervention	2019-09-13	<NULL>	<NULL>	2937	Sacrospinous ligament fixation using the Splentis anchoring system versus traditional technique for women with apical vaginal prolapse: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gvcbq	<NULL>	Women; age between 50 and 80 years; symptomatic cervical or vaginal prolapse greater than stage II; primary or secondary prolapse; with or without associated urinary incontinence	Genitourinary malignant neoplasia; pelvic radiotherapy; clinical diseases that made the surgical procedure unfeasible; collagen diseases; acute infectious disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-45nf55	Evaluation of the association of removable partial denture supported by implants distal extension.	Not yet recruiting	Intervention	2012-04-23	<NULL>	<NULL>	2938	Evaluation of the remaining alveolar ridge height, the masticatory efficiency and success rate of implants in patients with Kennedy Class I arches rehabilitated with removable partial dentures supported by implants.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-15	Neodent	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-45nf55	<NULL>	"All patients should have been rehabilitated at the Federal University of Rio Grande do Norte;
Every patient should be bilateral mandibular posterior edentulous;
Every patient should be larger than toothless in order to standardize the sample;
The patient must have a height between the mandibular canal and the alveolar bone margin posterior of at least 7mm."	"Will be excluded from the sample patients over 70 years or a weakened state of health;
Diabetic patients;
Patients with osteoporosis;
Patients with periodontal disease, patients not signing the consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-8mq8bs	Buried or exposed pins in wrist fractures - What causes more infection? A randomized clinical trial	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	2939	Buried or exposed K-wires in distal radius fractures - What causes more infection? A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-09	Universidade Federal do Pará	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-8mq8bs	<NULL>	Patients of both genders; equal or over 18 years-old; with distal third radius fracture treated with closed reduction and percutaneous fixation with 2 Kirschner wires of 1.5mm of caliber.	Patients under 18  years-old; open fractures; Immunossuppressed patients;  necessity of more than two Kirschner wires to fix the fracture; open reduction; associated fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-37v5s3	Efficacy of fluoride gel on incipient enamel lesions: a randomized clinical trial	Data analysis completed	Intervention	2018-05-14	<NULL>	<NULL>	2940	Efficacy of 1.23% acidulated phosphate fluoride gel on incipient enamel lesions: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-37v5s3	<NULL>	"Have at least one incipient enamel lesion in vestibular, palatal or occlusal surface in deciduous or permanent dentition; Have
access to fluoridated water and use fluoridated toothpaste."	Systemic alterations that may interfere in the development of caries; Have received topical fluoride in the last six months; Cognitive impairment who can not adhere to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-3gjdkr	The use of videogame as a resource for the recovery of post-stroke patients	Recruiting	Intervention	2019-09-13	<NULL>	<NULL>	2941	The use of virtual reality as a physiotherapist in the rehabilitation of hemiparetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-17	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-3gjdkr	<NULL>	30 individuals from UEAFTO will be recruited or by spontaneous demand. that obey the following criteria: patients of both sexes, aged 35 years and over, with diagnosis of Hemiparesis after ischemic stroke, with a predominant upper limb involvement, with the ability to ambulate, and who does not perform, at the time of the study, physiotherapeutic treatment	The study will not include individuals who do not have sufficient cognitive function to understand the commands and orientations during the course of the interventions, significant visual alterations that compromise the visualization of VR commands, balance changes associated with other diagnosed diseases, wheelchair or bedridden, who perform physiotherapeutic care during the period in which the study will be developed, individuals with uncontrolled systemic arterial hypertension with traumatic-orthopedic lesions and who do not sign the ethical consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-8s6cwz	Investigation of the effectiveness of elastic taping associated with thigh and hip strengthening in the treatment of anterior knee pain	Not yet recruiting	Intervention	2019-09-13	<NULL>	<NULL>	2942	Investigation of the efficacy of Kinesio Taping method with an exercise protocol to the treatment of Patellofemoral Pain: A randomised, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-15	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8s6cwz	<NULL>	"Inclusion criteria: 

Women;
Aged between 18 and 40 years;
Clinical diagnosis of patellofemoral pain (PFP);
Unilateral or bilateral symptoms;
History of anterior knee pain for at least three months;
Worsening pain in at least two PFP-related activities, such as climbing and descending stairs, jumping, kneeling, sitting for a long period;
Pain on palpation of the medial or lateral facet of the patella."	"Exclusion criteria:

Women with any degree of osteoarthritis;
History of previous surgery on the spine, hips, knees, ankle or foot;
History of patellar instability or patellar dislocation (traumatic or atraumatic);
History of a previous ligament or meniscal injury;
Sensibility to the material used to apply the Kinesio Taping method."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-6fy9t5	Electrical Stimulation and calf Exercises for leg Ulcer healing	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2943	Neuromuscular Electrical Stimulation and Exercises for calf for healing lower limb Venous Ulcers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6fy9t5	<NULL>	"Be over 18 years old;
Being a carrier of IVC, diagnosed by an angiologist, and classified in class 6 of CEAP (PORTER, MONETA, 1995)
Being able to wander and perform physical activities for 60 minutes with resting intervals;
Do not have decompensated cardiorespiratory insufficiency;
Have not had recent venous thrombosis;
Do not have neuropathies in the lower limbs;
Do not present intermittent claudication;
Be in possession of a medical certificate releasing it for the accomplishment of the proposed physical activities;
Have signed the consent form to participate in the study."	Painful ulceration; Active local infection; Inability to perform evaluation tests or treatment protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-439vzm	Vitamin D supplementation in patients with Cystic Fibrosis	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2944	Vitamin D supplementation in patients with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-23	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-439vzm	<NULL>	Serão incluídos no estudo crianças, adolescentes e adultos (até 20 anos) com diagnóstico de fibrose cística, vinculados ao serviço de Pneumologia da PUCRS, que aceitarem participar mediante a assinatura do Termo de Consentimento Livre e Esclarecido (TCLE)	Serão excluídos do estudo pacientes submetidos à avaliação de transplante de pulmão ou os já transplantados e aqueles colonizados com Burkholderia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-9wd3tt	Acute effect of cervical spinal manipulation on muscle strength: randomized clinical trial	Recruitment completed	Intervention	2019-09-16	<NULL>	<NULL>	2945	Effects of joint manipulation of the spine	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade do Estado do Amazonas	Centro Universitário do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9wd3tt	<NULL>	The individuals who were present at the University, volunteers, adults, who were asymptomatic about pain in the cervical region and signed the informed consent form were included.	Exclusion criteria were the absence of dysfunction in the cervical region when the evaluator applied the intervention, in addition to those who presented a positive response to the vertebral artery test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-2mg3xw	Effects of olive oil treatments for facial dark spots	Data analysis completed	Intervention	2019-09-16	<NULL>	<NULL>	2946	Clinical efficacy of oral and topical treatments based on olive oil extract titrated in hydroxytyrosol to melasma control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-2mg3xw	<NULL>	30 to 50 years old; phototype III and IV (Fitzpatrick, 1998); facial hyperpigmentations patterns.	hyperpigmentations not diagnosed as melasma in the malar region; pregnancy or breastfeeding; individuals with a history of adverse reactions with the use of cosmetic products; individuals in the use of drugs capable of producing an abnormal skin response; cosmetic and dermo-cosmetic whitening treatments, superficial chemical peels and laser for less than 3 months; use of oral antioxidant supplementation for less than 3 months; localized or generalized dermatological diseases; excess hair on face.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-5fqbj9	Turmeric and LED in the treatment of sore throat	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2947	Photodynamic action in the treatment of streptococcal pharyngotonsillitis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5fqbj9	<NULL>	Inclusion criteria: Age between 18a and 45a; Signature of the Informed Consent Form; Presence of fever&gt; 38ºC, oropharyngeal hyperemia, hypertrophy or presence of exudate in palatine tonsils.	Exclusion Criteria: Use of antibiotics in the 24 hours prior to admission without protocol; Clinical therapy using the antibiotic (sepsis, peritonsillar abscess, heart failure, immunodeficiency, clinical suspicion of Lemierre&apos;s syndrome).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-4stzq4	Cough and diaphragmatic breathing exercise: is there airway repercussion in children with cystic fibrosis?	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2948	Long-term follow-up of the Cystic Fibrosis patient profile	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Hospital Infantil Joana de Gusmão	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4stzq4	<NULL>	Children between six and 15 years of age; clinically stable; with diagnosis of CF confirmed according to the Brazilian Guidelines for diagnosis and treatment of CF; no neurological deficit; no auditory deficit; no visual deficit.	Children who are unable to perform or terminate IOS will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-63qsqx	Effects of Mindfulness on the well-being of college students	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2949	Effects of MBI (Mindfulness-Based Intervention) on the well-being of college students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-15	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-63qsqx	<NULL>	Men and women over 18 years of age; who are enrolled in an undergraduate or postgraduate course at a Brazilian university; who are interested in the objectives of the study; and who agree to participate in the research.	Uncompensated psychotic disorder; severe cognitive impairment; and / or have already completed a group of mindfulness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-9kk7p2	Liver consequences of cysteine, glutathione and taurine deficiency in classical homocystinuria	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2950	Functional consequences and therapeutic intervention in hampered production of cysteine, glutathione and taurine in classical homocystinuria	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Rio Grande do Sul	Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9kk7p2	<NULL>	Age over 18 years; for patients: molecular diagnosis of CBS deficiency	Patients with gastric, hepatic or kidney disease; smoking; illicit drug users;Acetaminophen or N-acetylcysteine hypersensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-94vwv2	Assessment of the hydration potential of a gynecological product and evaluation of the appearance of allergies or irritations.	Recruiting	Intervention	2019-09-16	<NULL>	<NULL>	2951	Evaluation of Dermal and Gynecological Acceptability of a Medical Device (Irritability and Sensitization in the Genital Mucosa) and Evaluation of the Moisturizing Potential by Corneometry	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-12	Medcin Instituto da Pele Ltda.	Medcin Instituto da Pele Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-94vwv2	<NULL>	Healthy women complaining of vaginal dryness; Age range between 45 and 65 years; Intact skin in the region of product analysis; No history of reaction to topical products	Pregnancy or risk of gestation and or lactation; pathologies and or cutaneous lesions such as psoriasis, sensitive skin, skin cancer, rosacea, atopic dermatitis or other medical criteria to be considered at the time of evaluation; hyperpigmentation in the area of Test that interfere in the evaluation of possible reactions vascular malformations, scars, increased pilosity and large amount of nerves; Active cutaneous pathologies and or lesions local and or disseminated in the evaluation area; use of the following Topical or systemic medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to 30 days before selection or considering immunosuppressants, the interval should be 3 months before selection; Decompensated endocrinopathies; Immunosuppression by drugs or active diseases; Relevant clinical history or current evidence of abuse of alcohol or other drugs; Aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; Alteration of hygiene habits up to 04 weeks before selection, such as: Alteration of brand and type of body and intimate soaps and etc. ; Atopic or allergic antecedents to category products; Known history or suspected intolerance to Products of the same category; Cutaneous markers in the experimental area that interfere in the evaluation of possible cutaneous reactions vascular malformations, scars, increased pilosity and nevus in large quantity; Participants with Known congenital or acquired immunodeficiency; Professionals directly involved in conducting the present study both from the research center and from the sponsor; Other conditions considered by the appraiser physician as reasonable for Disqualification of the study&apos;s participation. If yes, it should be described under observation in the clinical form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-493n4m	Evaluation of Three Methods to Predict Difficult Intubation during Anesthesia	Recruitment completed	Observational	2016-08-09	<NULL>	<NULL>	2952	Evaluation of Three Multivariate Models for Predicting Difficult Intubation During Anesthesia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-12-01	Hospital Lifecenter	Hospital Lifecenter	https://ensaiosclinicos.gov.br/rg/RBR-493n4m	<NULL>	Patients scheduled to undergo surgery with general anesthesia and tracheal intubation	Refusal in participate, Facial or cervical trauma, Airway pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-45qckt	The effect of sodium bicarbonate intake on performance and tiredness after repeated exercise in soccer players	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2953	Effect of Sodium Bicarbonate intake on performance and fatigue following a repeated sprint session in soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-45qckt	<NULL>	The inclusion criteria adopted for participation in this research were soccer players from a professional soccer club; age between 14 and 15 years; in systematized training; no previous history of muscle injuries, no regular use of medications; have parental or maternal authorization to participate in the study.	The exclusion criteria adopted for participation in this research were unavailability for participation in the assessments; in use of food supplementation; history of injury in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-4vsv5c	Depression Acceptance and Commitment Therapy in the Elderly	Data analysis completed	Intervention	2019-09-17	<NULL>	<NULL>	2954	Cognitive Behavioral Therapy and Geriatric Depression: A Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4vsv5c	<NULL>	60 years or older; reside in the research city; not being in psychotherapy, achieving the expected score on the EDG-15 (instrument for geriatric depression) and the MMSE (cognitive deficits).	Not reside in the research city; being in psychotherapy; present evidence of dementia (MMSE) or absence of depressive symptoms (EDG-15) in the respective instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-3h5sc8	Adding expiratory muscle training to breath stacking technique on clinical and functional outcomes in patients with neuromuscular disease	Not yet recruiting	Intervention	2019-09-17	<NULL>	<NULL>	2955	Comparison between maximal insufflation technique associated with expiratory muscle training with maximmum isolated insufflation in patients with neuromuscular diseases	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3h5sc8	<NULL>	"Diagnosis of neuromuscular disease confirmed by neurologists at the referral center for neuromuscular diseases at Brasília Support Hospital prior to screening for recruitment; age over 16 years; preserved cognition, evidenced by a score greater than or equal to 24 points in the Mini-Mental Status Exam;no barium allergies; without tracheostomy or mechanical ventilation; no diaphragmatic pacemaker
- without associated respiratory disease"	less than 16 years; pregnancy; previous kidney disease or other concomitant diseases; respiratory diseases during the study; hospitalization in intensive care units (ICUs) during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-5f9gps	Evaluation of the strategy of applying universal adhesives on non-carious lesions	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2956	Evaluation of adhesive strategy of universal adhesives in Non-Carious Cervical Lesions: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-11-19	CEUMA - Centro Universitário do Maranhão	CEUMA - Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5f9gps	<NULL>	Age between 18 and 70 years; minimum of 4 non-carious cervical lesions per individual; minimum of 20 teeth in occlusion; good oral hygiene; cervical lesions deeper than 1mm; vital teeth; teeth without mobility.	Endodontically treated teeth; periodontal disease; xerostomia; orthodontic appliance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4wwj44	Performance of healthy elderly and Parkinson&apos;s patient in a dual task	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2957	Executive function and verbal fluency assessment in patients with Parkinson disease	<NULL>	4, single-arm-study, double-blind	4	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4wwj44	<NULL>	"Being able to read and write, normal or corrected vision to both groups.
PD group: 3 or lower score on Hoehn &amp; Yahr scale, being able to perform part B of Trail making test in no longer than 300 seconds."	Score below the standardized values (according to the number of years of education) in Mini Mental State Examination, uncontrolled cardiovascular, respiratory, orthopaedic, reumatologic, metabolic disease by self-report, absence in the second session of training and assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4p9s5y	The use of the Laser for treatment of Sclerosus Lichen in the female external genitalia	Recruiting	Intervention	2019-09-17	<NULL>	<NULL>	2958	Use of CO2 Laser therapy for the treatment of Vulvar Atrophic Sclerosis Lichen	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-03-27	Hospital Universitário da Universidade Federal de Juiz de Fora - UFJF	Hospital Universitário da Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-4p9s5y	<NULL>	Women attended at the outpatient clinic of the Gynecology Service of the University Hospital of the Federal University of Juiz de Fora - UFJF, with genital atrophic lichen sclerosus diagnosed by histopathological evaluation of vulvar biopsy.	Women who have used or used other therapeutic methods for lichen in the last 30 days; women with differential diagnoses identified in the biopsy, such as vulvar intraepithelial neoplasia or vitiligo.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-7pxgth	Muscle training program on very old people with systemic arterial hypertension	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2959	Effects of a physical activity program on very old people with systemic arterial hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade Federal de Goiás/ Faculdade de Medicina	Universidade Federal de Goiás/ Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-7pxgth	<NULL>	Elderly people with 80 years old or more, enrolled in the service for more than 6 months; who have not exercised for at least three months; stable hypertension (no change in hypotension for at least 3 months) and agree to take part in the research through signing of the Informed Consent Forms (ICF).	"Hypertension, Congestive heart failure, recent myocardial infarction less than 6 months or in rehabilitation, recent embolism (systemic or pulmonary, acute infectious diseases, ventricular tachycardia and other severe arrhythmias, neuromuscular diseases untreated, or musculoskeletal and joint diseases untreated, chronic renal insufficiency, unbalanced diabetes
recent cerebrovascular accident (less than 6 months) or incapacitating, medical certificate denying the physical ability to practice physical activity; clinical and laboratory tests that contra indicates the practice of physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-86yjpg	Effect of açaí-juçara pulp consumption on inflammation of overweight adults	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2960	Effect of juçara pulp (Euterpe edulis Martius) in epigenetic modifications and inflammatory status in monocytes of obese adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal de São Paulo - UNIFESP campus Baixada Santista	Universidade Federal de São Paulo - UNIFESP campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-86yjpg	<NULL>	The study included volunteers with obesity (BMI between 30.0 and 39.9 kg / m2) with insufficiently active lifestyle, male and female, aged 31 to 59 years, according to the classification of the adult phase of the Organization World Health Organization (WHO, 2005).	Body mass index (BMI) below 29.9 kg/m2 or above 40.00 kg/m2; Infectious diseases and/or severe chronic diseases; Using medications that interfere with the inflammatory cascade, lipid metabolism and food consumption, such as statins, aspirins, hormones and/or antidepressants; Abuse of alcohol and drugs; - Pregnancy; Menopause.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-9c2my6	Comparison of two components in phenol peels	Recruitment completed	Intervention	2019-09-17	<NULL>	<NULL>	2961	Randomized controlled trial comparing the Efficacy of two components in the Phenol-croton oil formula	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital Heliópolis	Hospital Heliópolis	https://ensaiosclinicos.gov.br/rg/RBR-9c2my6	<NULL>	phototypes between I and III according to Fitzpatrick&apos;s; photoaging according to Global Photoaging Score Types III and IV; non smoking	"Recent history of skin lesions or surgeries in the past three months; Medical history of heart disease and/or arrhythmias of any nature, kidney failure or hepatic disease; Medical history of Asthma or Chronic Obstructive Pulmonary Disease (COPD); Medical history of Iron Overload (Hemochromatosis); Use of oral Isotretinoin (13-cis-retinoic acid) in the past six months; Patients with immunosuppressive Conditions, Decompensated Diabetes or Systemic Conditions which interfere on the healing/scaring process such as Malnutrition and Neoplasms; Personal history of keloid.
Smoking.
Collagenose.
Pregnancy or Breastfeeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-2gw2f5	Clay poultice combined with therapeutic exercises for pain reduction in patients with osteoarthritis	Data analysis completed	Intervention	2019-09-18	<NULL>	<NULL>	2962	Effect of geotherapy combined with kinesiotherapy and resistance exercise in knee osteoarthritis: single-blinded randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Centro Universitário Adventista de São Paulo	Centro Universitário Adventista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gw2f5	<NULL>	diagnosis of osteoarthritis; older than 20 years of age	presence of any other chronic disease; total or partial prosthesis in one or both knees or hips; presence of heart disease; uncontrolled hypertension; rheumatoid arthritis; fibromyalgia; neurological diseases affecting mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-8sdwws	Mindfulness in the care of students and the perception of their teachers and family members in the promotion of well being	Recruitment completed	Intervention	2019-09-18	<NULL>	<NULL>	2963	Mindfulness and Storytelling with elementary students and Perception of practice by teachers, family and students	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Universidade Federal de São Paulo	Natura	https://ensaiosclinicos.gov.br/rg/RBR-8sdwws	<NULL>	Educators, teachers and family members of the Elementary School of EMEFs.	Students and teachers who are away, holiday or retired will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4vp7gw	Effect of a balance training in the postural control in patients during hemodialysis	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2964	Effect of a balance training in the static postural control in patients during hemodialysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-20	Universidade Federal de Juiz de Fora	Faculdade de Fisioterapia UFJF	https://ensaiosclinicos.gov.br/rg/RBR-4vp7gw	<NULL>	Volunteers in hemodialysis for at least 3 months; both genders; at least 18 years old; agrred to sign the consent form	Volunteers presenting cognitive impairment; physical impairment;  unstable and severe comorbidities; hospitalization in the last 3 months before teh study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4f7g2x	Use of current Aussie-type neuromuscular electrostimulation with abdominal fat and muscle resistance evaluations	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2965	Effect of the Aussie current on localized fat and abdominal resistance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-4f7g2x	<NULL>	over eighteen years of age; female; have fat located in the abdominal region; have a BMI greater than 18.5 and less than 29.99; sedentary	obesity; perform any type of aesthetic procedure with the purpose of reducing localized fat; have some contraindication to the use of the Aussie current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-9y6qvx	Evaluation of pulmonary expansion technique in the immediate postoperative period of cardiac surgery	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2966	Alveolar Recruitment Maneuver in the Post Operative Heart Surgery: Randomized Clinical Trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-02-19	ICS UFBA	ICS UFBA	https://ensaiosclinicos.gov.br/rg/RBR-9y6qvx	<NULL>	Older than 18 years. Both sexes. Admitted to the cardiovascular unit of the Ana Nery Hospital. Patients in immediate postoperative cardiac surgery, namely: myocardial revascularization and aortic or mitral valve exchanges, or the combination of these surgeries.	Thoracic deformity. Difficulty or inability to swallow and release airways. No cough reflex. Hemodynamic instability. Psychomotor agitation. Previous pneumectomy. Risk of pleural fistula. Postoperative pulmonary resection. Bullous or cavitary lesions. Hemoptysis. Non-drained pneumothorax. Increased intracranial pressure &gt; 20 mmHg if sustained. Patients with neuromuscular diseases. Neurological complications during the postoperative period. Dependence on mechanical ventilation. Previous cardiac surgery. Chronic obstructive pulmonary disease. Emphysematous Bubbles. Asthma. Morbidly obese. Pulmonary hypertension. Left ventricular dysfunction with ejection fraction lower than 35%. Emergency surgery. Use of ventricular assist device. Arrhythmia associated with hemodynamic instability. Alveolar hemorrhage. Signs of refractory hypoxemia on admission. Pulmonary thromboembolism. Unilateral total atelectasis (a patient with a need for bronchoscopy). Chest wall Trauma. Need to transfer to another hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4j342n	Acute Effect of Interval and Continuous Training of Moderate Intensity on Cardiometabolic Responses of Type 2 Diabetics Hypertensive subjects	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	2967	Acute Effect of Interval and Continuous Aerobic Training of Moderate Intensity on Blood Glucose, Blood Pressure and Flow-Mediated Dilatation of Type 2 Diabetics Hypertensive subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4j342n	<NULL>	Subjects of both sexes; aged 40-60 years; with type 2 diabetes; with hypertension on stage one or two; with no history of regular exercise for at least six months; with sedentary habits	Subjects with cardiovascular disease; individuals with comorbidities associated with diabetes; with any other chronic disease; subjects with functional limitations; with joint problems; smokers; who use insulin; who use vasodilatory medications; women who have not reached menopause; women doing hormone replacement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-2pb8gq	Development of a Brain-controlled Gait Apparatus to restore the walking of people with Spinal Cord Injury	Data analysis completed	Observational	2019-09-18	<NULL>	<NULL>	2968	Walk Again Project: development of a Robotic Orthosis Controlled by Biological Signals to restore the ambulation in patients with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-04	Associação Alberto Santos Dumont para Apoio à Pesquisa	Associação Alberto Santos Dumont para Apoio à Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-2pb8gq	<NULL>	18 years old or over; Lesion T4 to L2; SCI AIS A, B, C or D; Presence of chronic, traumatic, six months to 3 years of SCI.	"Has seizures; Has contractures in the legs (shortening of a muscle or tendon); Do not have time for project activities; Participates in other research; Cardiopulmonary instability; Abuse of alcohol or drugs, psychiatric illness, or history of head trauma with loss of consciousness within 3 months of recruitment; Use of drugs known to exert negative effects on motor recovery; Cognitive deficit; Pregnancy or of childbearing potential and not using adequate contraception; Presence of ferromagnetic material in the skull, except in the mouth; 
Presence of cardiac and/or neural pacemakers;
Untreated depression; Spasticity at the lower end of a MAS score equal or higher than 2; Uncontrolled diabetes; Severe osteoporosis; Decubitus ulcer that may interfere with the belt placement or any other necessary feature of the LT BWST-assisted robot and the exoskeleton."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-8dymr8	Impact of a nurse-oriented educational strategy on the reduction of hospital readmissions in patients with heart failure	Data analysis completed	Intervention	2019-09-18	<NULL>	<NULL>	2969	Impact of a nurse-oriented educational strategy on the reduction of hospital readmissions in patients with heart failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8dymr8	<NULL>	Patients of both sexes. Aged 18 years or more. With the medical diagnosis of heart failure with systolic dysfunction ejection fraction greater than or equal to 49% by the echocardiogram. Admitted for clinical decompensation related to changes of vital parameters and laboratory tests and/or image.	With cognitive deficit assessed by mine mental State examination. Without the possibility of telephone contact. Functional Class 4 by NYHA. With visual, auditory deficit and impaired mobility. And those who are participating in another research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:01
RBR-5kh98y	Use of Allopurinol versus Trimetazidine as the third drug for the relief of angina pectoris. Randomized clinical trial	Recruiting	Intervention	2019-09-19	<NULL>	<NULL>	2970	Allopurinol versus Trimetazidine as a Third-Drug Therapy for Angina. A Randomized Clinical Trial.	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-07-15	Faculdade de Medicina da Universidade Federal da Bahia	Faculdade de Medicina da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5kh98y	<NULL>	"Patients with stable coronary artery disease (CAD)
diagnosis through cardiac catheterization evidencing at least
an epicardial coronary artery with stenosis greater than 70%. Symptomatic angina despite clinical treatment
optimized with a beta-blocker agent at a maximum tolerated dose and a
dihydropyridine calcium channel antagonist agent. Age&gt; 18 years. Consent to participate in the study."	Patients with obstruction of the left coronary artery greater than 50%. Patients who are asymptomatic from angina after initial clinical optimization. Acute myocardial infarction in the last 2 months. Renal insufficiency with creatinine clearance &lt;45ml / min. Hepatic insufficiency. Concomitant use of azathioprine. Refusal to participate in the study and / or sign the informed consent form. Participation in another research protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-9zr2fr	Immersion anesthesia in  knee arthroplasty surgery: a new proposal to reduce pain and analgesics consumption.	Recruiting	Intervention	2019-09-19	<NULL>	<NULL>	2971	Immersion anesthesia in total knee arthroplasty: a new proposal to reduce pain and opioid consumption. Randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Fundacao Hospital Adriano Jorge	Instituto de Ortopedia e Traumatologia da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-9zr2fr	<NULL>	Patients regularly enrolled in the institution where the study will be performed  with classic indication scheduled for knee replacement, recommended by Camanho, will be included: medial or lateral clamping with obliteration of the articular space, deviations in the femoro-tibial varus greater than 15 degrees. Deviations in femoro-tibial valgus greater than 10 degrees; frontal plane femorotibial subluxation greater than 10mm. Tibial anteriorization in relation to the femur on lateral radiographs. Severe impairment of two of the three knee joint compartments (medial femorotibial, lateral femorotibial or patellofemoral), and conservative treatment failed for at least three months when these criteria were not met. Patients with primary degenerative knee osteoarthritis. For this radiographic evaluation, patients with knee arthrosis stage  III and IV were considered according to the Kellgren-Lawrence classification. Patients aged 50 to 80 years. Patients who are willing and able to sign written informed consent for study involvemen. Following a reasonably detailed study description, patients willing to participate in treatment, as well as pre-, intra- and postoperative evaluation criteria. Patients operated by the principal investigator and his team	Patients with previous knee surgeries will be excluded from the study. History of knee fractures. Neurological, muscular, rheumatological, neoplastic or infectious diseases that could cause some form of joint involvement (gout, multiple myeloma, psoriasis, lymphoma, Paget&apos;s disease, rheumatoid arthritis, chronic renal failure, osteomyelitis, ankylosing spondylitis, systemic lupus erythematosus.; Patients undergoing revision or bilateral knee replacement.  Patients with more than 30 degrees of malalignament  of the knee (varus or valgus) tibial femoral.  Patients with any contraindications to the use of acetaminophen, aspirin, tranexamic acid, tenoxicam, dexamethasone or any other study-related medication; Patients on chronic opioid use (defined as daily use for more than 3 months). Patients with advanced kidney disease (defined as Glomerular Filtration Rate minus than 30) or severe liver disease.  Patients who are chronic alcohol users (defined as more than 1 dose per night for women or more than 2 doses per night for men. Patients with a score of  3 from the American Society of Anesthesiologistis. Patients with poorly controlled diabetes mellitus (glycated hemoglobin bigger than 7.5 in pre-admission tests). Patients on steroid or immunosuppressive drugs within 3 months of surgery. Preoperative history of venous thromboembolism or deep vein thrombosis. Patients with a hypercoagulability disorder. Patients with a concomitant physical condition that may require analgesic treatment during study follow-up. Patients with body mass index bigger than 40 kg / m2. Patients with bacteremia, systemic infection or surgical site infection. Patients currently involved in another drug or device study. Patients undergoing general anesthesia. Patients not operated at the study hospital. Refusal or impossibility of the patient to perform postoperative rehabilitation. Non-acceptance by anesthesiologist to follow project protocol. Allergic patients to the medications used in the protocol. Patients who claim to be indigenous	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4z26bv	Impact of Community Health Agent&apos;s Capacitation on Food Education	Recruitment completed	Intervention	2019-09-19	<NULL>	<NULL>	2972	Impact of Community Health Agent&apos;s Capacitation on Food Education: pilot study in Vitória/ES	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Espírito Santo	Secretaria Municipal de Saúde de Vitória	https://ensaiosclinicos.gov.br/rg/RBR-4z26bv	<NULL>	Participating in this stage will be the Community Health Agents linked to the service of the municipality of Vitória / ES with at least 18 years of age that has agreed to participate in the study by signing the Term of Free and Informed Consent (TCLE).	Cognitive problems that compromise data collection and participation in educational activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-4v4298	Respiratory Exercises with children with Cleft lip and/or palate	Data analysis completed	Intervention	2019-09-19	<NULL>	<NULL>	2973	Muscular expiratory training in children with cleft lip and/or cleft palate: Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Hospital da Criança Santo Antônio	https://ensaiosclinicos.gov.br/rg/RBR-4v4298	<NULL>	Subjects with Cleft Lip and/or Palate; aged between three and 12 years; corrected by surgery of cheiloplasty and palatoplasty	Patients with cleft lip and palate who had any other associated malformation; those with intellectual disability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-2c6ymn	Effects of shiatsu-associated physical therapy on pain and fatigue in patients with Multiple Sclerosis	Recruiting	Intervention	2019-09-19	<NULL>	<NULL>	2974	POSSIBLE SHIATSU EFFECTS ON PAIN AND FAILURE IN PEOPLE WITH MULTIPLE SCLEROSIS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-06	Centro Universitário Filadélfia	Centro Universitário Filadélfia	https://ensaiosclinicos.gov.br/rg/RBR-2c6ymn	<NULL>	Volunteers with diagnosis of multiple sclerosis; of both sexes; older than 18 years; with staging of 0 to 6; were not classified during the 3-month period prior to the start of the study.	Volunteers with neurological diagnosis besides multiple sclerosis; unable to understand or perform the tests proposed in the study; the physical or psychological impossibility of individuals; being hospitalized at the time of data collection or outbreak at the time of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-76xrqj	Effect of psychotherapy on Heart Failure	Data analysis completed	Intervention	2019-09-20	<NULL>	<NULL>	2975	Mental health in Heart Failure: prevalent diagnoses and psychological intervention from short-term psychoanalytic listening	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-11	Faculdade de Medicina da Universidade Federal Fluminense	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-76xrqj	<NULL>	Patients over 18 years of age and of any NYHA functional class	Psychotherapy patients; with psychotropic use during intervention; severe neurological sequel; severe psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9b3fzp	High intensity interval exercise and cardiopulmonary capacity	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2976	Effect of different protocols of high intensity interval exercise with low volume on the cardiorespiratory capacity of inactive adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b3fzp	<NULL>	The inclusion criteria in the study are: age between 18 and 40 years;  male and female sex;  be apparently healthy;  physically inactive (ie individuals who perform less than 150 min / week of moderate physical activity or less than 75 min / week of vigorously active physical activity regularly for at least three months (verified by accelerometer) ; Body mass index (BMI) between 18.5 kg / m2 and 29.9 kg / m2;  without ostiomioarticular lesions; have experience with treadmill exercise.	The exclusion criteria of the study are:  individuals who regularly practice high intensity interval exercise;  use of drugs that modulate cardiorespiratory function;  being smoker or stopped recently (in the last 6 months) and  any type of injury that makes it impossible to continue the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4w6yh4	Stress and metabolic markers in response to acute exercise	Data analysis completed	Intervention	2017-07-31	<NULL>	<NULL>	2977	Stress and metabolic markers in response to acute exercise in women between 25 and 40 years of age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde	Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4w6yh4	<NULL>	Apparently healthy women; Sedentary; Do not be a smoker; Without hypertension, diabetes, hyper or hypothyroidism; No use of antinconceptional or any hypoglycemic.	Participant with hypertension; diabetes; Use of medications that influence the cardiovascular or endocrine system; With musculoskeletal limitation for walking or running. Also, do not agree to participate in all research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-53wq87	Orientation of perineal exercises during postpartum to prevent urinary loss	Recruiting	Intervention	2012-01-26	<NULL>	<NULL>	2978	Study about the influence of pelvic floor exercises orientation regarding urinary loss prevention on postpartum period	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-53wq87	<NULL>	Women that had a vaginal or cesarean delivery during the study period on Maternidade Carmela Dutra, Florianópolis, SC	"Postpartum women that present the following conditions: 
- neurologic urinary incontinence
- history of urogenital cancer
- cognitive deficit
- diagnosed neurological diseases
- blindness
- illiterate
- younger than 18 years old
- episiotomy associated with local conditions (important edema and excessive pain)
- drug dependents
- those that do not have a telephone for further contact."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4995cr	Influence of verbal command on upper limb motor improvement of subjects after stroke	Data analysis completed	Observational	2019-09-20	<NULL>	<NULL>	2979	Different focus of attention on improvement of upper limb motor performance post-stroke	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi (Facisa)	https://ensaiosclinicos.gov.br/rg/RBR-4995cr	<NULL>	"Greater than 18 years old;
Clinical diagnosis of stroke (ischemic or hemorrhagic);
Just one stroke;
Realize flexor and extensor synergies by the Fugl Meyer scale;"	"Sensory impairment;
Cognitive impairment;
Aphasia;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9frj8q	Effects evaluation of web-based tailored tool to prevent mistreatment among intimate partners	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2980	Usability and efficacy evaluation of a web-based tailored intervention to prevent dating violence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Departamento de Psicologia Clínica da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9frj8q	<NULL>	It will be included youth aged 15 - 29 years old involved in a current affective-sexual relationship	"To have less than 15 years old and more than 29 years old;
Do not be involved in a current affective-sexual relationship during recruitment phase"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4w2qwh	Comparative study between two techniques of applying Dry Needling to painful neck points in young adults	Recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2981	Comparative study between two techniques of  Dry Needling applying on trigger points in young adults with Neck Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-21	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-4w2qwh	<NULL>	Of both sexes; aged between 18 and 30 years; with pain in the cervical region (neck pain); presence of upper trapezius trigger points and scapular lift	Individuals who are using pain-reducing medication (s) and / or have effects on skeletal muscle, anticoagulant medications, individuals with decompensated diseases, haemophilia, who are allergic to needle metal, with needle phobia or who are undergoing some other treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-78vcb9	Healthy Eating Promotion Program	Recruitment completed	Intervention	2019-09-22	<NULL>	<NULL>	2982	Evaluation of the implementation and effectiveness of the Healthy Eating Program in Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Universidade Federal de Minas Gerais - UFMG	Secretaria Municipal de Saúde de Nova Lima	https://ensaiosclinicos.gov.br/rg/RBR-78vcb9	<NULL>	20 years of age or older; be enrolled in the UBS; present a cognitive capacity that allows answering the questionnaires and / or participating in the actions.	The units that participated in research and extension activities focused on the promotion of healthy eating in the past two years and professionals that are linked to the development of the research, in order to avoid the influence of other interventions on the results, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-55g6cm	Evaluation of the effectiveness of toothpastes in reducing gum bleeding	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2983	Evaluation of the effectiveness of toothpastes in reducing gum bleeding	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55g6cm	<NULL>	Good general health; ability to read, understand and sign the Informed Consent Form; willingness to comply with study procedures and sampling schedules; at least 20 natural permanent teeth without crown (excluding third molars); mean gingival index (Löe &amp; Silness 1967) greater than or equal to 1.5; at least 6 teeth with a minimum of one bleed site on marginal probing	Have a history of allergy to previously used oral hygiene products or their ingredients; have a history of alcohol or drug abuse; have infectious diseases (e.g hepatitis or AIDS); have a medical condition that could compromise patient safety or the quality of study results; need antibiotics before dental treatment; use anti-inflammatory, immunosuppressive, antimicrobial, anticoagulant or antibiotic drugs within 30 days prior to the start of the study; continuous use of medications known to affect gum tissues; have important oral conditions (including but not limited to oral or soft tissue hard tumor (s), gingival hyperplasia, moderate to severe periodontitis including two or more periodontal pockets greater than 5 mm with bleeding on probing),presence of orthodontic bands or removable partial dentures; presence of five or more carious lesions requiring immediate restorative treatment; being pregnant or breastfeeding; referring to the use of tobacco products; having any pre-existing medical condition prohibiting the subject from eating or drinking for periods of up to 2 hours, have participated in a clinical study involving oral care products in the previous month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9hc9dz	Agents used for dental sensitivity during whitening: a clinical study	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2984	Evaluation of In-Office Desensitizing Agents used during 35% Hydrogen Peroxide Bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	São Leopoldo Mandic - SL Mandic	São Leopoldo Mandic - SL Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9hc9dz	<NULL>	Presence of at least 20 permanent teeth (including all anterior teeth); be between 18 and 30 years of age; absence of restorations in the six upper anterior teeth; absence of active caries or periodontal disease; commitment not to use tobacco during the study period.	History of any systemic disease that may interfere with the results; have undergone any previous bleaching treatment; patients using analgesics and / or anti-inflammatories; pregnant or breastfeeding patients; Patients smokers; teeth with tetracycline stains; patients with orthodontic appliances or removable prostheses; patients with gingival retraction or with cracks in the enamel; patient with previous dental sensitivity; patient with poor oral hygiene and presence of active caries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-6bvnx6	Physical therapy to improve walking in people with Parkinson&apos;s Disease.	Recruiting	Intervention	2019-09-23	<NULL>	<NULL>	2985	Effect of the transcranial direct current stimulation (tDCS) associated with Physical Therapy on freezing of gait and functionality after Parkinson’s disease.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6bvnx6	<NULL>	Participants will be individuals with Parkinson’s Disease, who will be eligible, if they: are over 40 years of age; are able to walk at least 14 meters, independently, with or without assistive devices; walk at speeds lower than 1.1 m/s; have experienced freezing episodes over the past month, according to the Part I of the New Freezing of Gait Questionnaire (Nieuwboer et al 2009); have adapted to their current anti-Parkinsonian medication for at least 2 weeks; provide written consent.	They will be excluded, if they: have cognitive deficits, which will be screened by the Mini-Mental State Examination. The cut-off scores are 26 for people with high levels of education, 18 for people with elementary and middle levels, and 13 for illiterate people (Bertolucci et al 1994);suffer from unstable cardiovascular disease or other uncontrolled chronic conditions that would interfere with the safety and conduct of the training and testing protocol or interpretation of the results; over 100 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4yy2f8	Health education for the interaction between mother and baby in the neonatal unit	Recruiting	Intervention	2019-09-23	<NULL>	<NULL>	2986	Nursing educational technology for the promotion of the mother-child bond in a neonatal intensive care unit	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4yy2f8	<NULL>	The sample will consist of the mother-child binomial in NICU with Gestational Age between 31 weeks and 36 weeks and 6 days. The booklet will be applied to mothers of newborns during the first three days of hospitalization of the baby in the NICU.	"Mothers with less than 8 years of education required to understand the educational booklet, mothers of preterm or congenital malformations and term newborns with hypoglycemia or mild respiratory discomfort are excluded since it is necessary in the least 8 days of follow-up in the survey.
For the non-participating observation phase, mothers who do not have a frequency of visits of at least 3x per week will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-2dhtzh	Adherence to self-care in leprosy in the light of Everett Rogers Theory	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2987	Adherence to self-care in leprosy in the light of Everett Rogers Theory	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Programa de Pós-Graduação em Enfermagem da Universidade Federal da Paraíba	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-2dhtzh	<NULL>	Patients in treatment with MDT who met the inclusion criteria were considered eligible: age of majority, confirmation of leprosy diagnosis, multibacillary operational classification, with treatment between the second and ninth supervised dose (avoiding termination of the treatment during the intervention process).	The new cases, considering that these situations individuals receive guidance at the time of consultation, and therefore have a prior lack of a pathological condition; those unable to perform activities of self-care due to visual impairment, mental disorder and / or severe physical limitations; and patients with disabilities of cognitive understanding that prevent participation in educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-3zfkgt	Bleaching efficacy and tooth sensitivity of active application of a in-office bleaching agent	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2988	Clinical evaluation of 20% hydrogen peroxide in-office bleaching gel effectiveness with and without sonic activation in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3zfkgt	<NULL>	Being aged 18 years old or older, having good general and oral health, having anterior maxillary teeth free of cavity or restorations on buccal surface, having maxillary central incisors shaded on C2 ou darker assessed by Vita Classic (Vita Zahnfabrik, Bad Säckingen, Alemanha).	Participants with orthodontic devices, pregnant or lactating, severe internal tooth discolouration (tetracycline, fluorosis or pulpal death), bruxism or other pre-existent pathologies that may cause spontaneous tooth pain (gingival recession or dentin exposure), non-carious cervical lesions, anterior restorations or who were using antioxidant or antiinflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-99gyq8	Effects of pulmonary rehabilitation-associated melatonin hormone on sensation of difficulty breathing, respiratory muscle strength, ability to perform daily living activities and sleep quality in individuals with chronic lung disease	Not yet recruiting	Intervention	2019-09-24	<NULL>	<NULL>	2989	Effects of pulmonary rehabilitation-associated melatonin on dyspnea, respiratory muscle strength, functional capacity, and sleep quality in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-03	Universidade Federal do Ceará Programa de Pós Graduação em Ciencias Médicas	Centro Universitário Estácio do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99gyq8	<NULL>	Selection criteria for rehabilitation program will includ patients from the Pulmonology Service of the WCUH-FUC; of both sexes; above 18 years; with medical diagnosis of Chronic obstructive pulmonary disease based on the Global obsctructive lung disease guideline; stability with no exacerbations or worsening of respiratory symptoms; no increased use of rescue medication and ability to mobilize independently	The exclusion criteria for rehabilitation program will be the patient will submit to exacerbation of Chronic obstructive pulmonary disease; orthopedic or neurologic impairment that might render the subjects incapable of completing the exercise training; patients who not continue rehabilitation for 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-2v26nz	The effectiveness of electrical stimulation in the head and sleep quality in patients with Parkinson&apos;s disease: assessment of balance before and after stimulation	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2990	The efficacy of cranial electroacupuncture and sleep quality in patients with Parkinson&apos;s disease: assessment of pre and post-intervention balance	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-05	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2v26nz	<NULL>	Score on the Hoehn &amp; Yard scale between two and three; Score on the MoCA scale above twenty-five; More than one year of Parkinson&apos;s disease; Six months or more of levodopa use.	Neuromuscular, visual and vestibular diseases; Falls in the last six months; Use of medications that affect balance; Exercises twenty-four hours before the evaluation;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-9dx9g7	Analysis of bone loss around implants subjected to immediate occlusal loading and late occlusal loading	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2991	Radiographic and microbiological evaluation of periimplant bone surface. Clinical study comparing Immediate-Loaded Implants and Late-Loaded Implants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-9dx9g7	<NULL>	Inclusion criteria were patients with single or múltipla; unilateral or bilateral losses of molars or lower premolars; with age above 18 years of both sexes; non-smokers; free of systemic problem;, with good oral health status and did not require previous bone reconstruction.	The exclusion criterion was the patients who did not agree to participate in the study and did not fulfill the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-7dg79b	Application of a Physiotherapy treatment for undiagnosed Headache associated with muscle pain in students of a public university	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2992	Application of a Physiotherapeutic Protocol for nonspecific muscle tension-associated Headache in students of a public university	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7dg79b	<NULL>	Individuals regularly enrolled in the UEPA Physiotherapy course of both sexes who present a non-specific headache at least once a week, associated with muscular tension in the neck, shoulders or back of the body.	Individuals with a specific diagnosis of specific headache; headache frequency less than once a week; individuals with headache not associated with muscle strain on the neck, shoulders or back of the body; individuals who are not available twice a week for the application of the physiotherapeutic protocol and who present a contraindication to the use of infrared.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-33ybrc	Study of the therapeutic effect of an added gel with Pequi Oil on the functionality of patients with knee osteoarthritis.	Recruiting	Intervention	2018-04-29	<NULL>	<NULL>	2993	Study of the therapeutic effect of nanoestrutured pharmaceutical preparation incorporated with Pequi Oil (Caryocar Coriaceum) in the functionality of patients with Gonartrosis.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Fundação Universidade Federal do Sergipe	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-33ybrc	<NULL>	"Be over 50 years old; Radiography showing grade 2 to 4 gonarthrosis according to the Kellgren-Lawrence scale (KELLGREN, et al., 1957); Pain in the knee; Complete at least one of the American College of Rheumatology (ALTMAN, et al., 1986) classification criteria.
According to Kellgren-Lawrence (1957), changes in X-rays caused by osteoarthrosis are classified as: normal (grade 0); possible narrowing of joint space and defined osteophyte (Grade II); defined narrowing of the joint space, multiple moderate osteophytes, some subchondral sclerosis and possible deformity of the bone contour (Grade III); articular space narrowing, severe subchondral sclerosis, defined deformity of the bone contour and presence of large osteophytes (Grade IV).
The classification criteria of the American College of Rheumatology are (ALTMAN, et al., 1986): Clinical and physical evaluation (knee pain and three of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, bone fragility, joint heat). Clinical, physical and radiographic evaluation (knee pain and one of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, crackling of the active movement and presence of osteophytes).
Clinical, physical, and laboratory evaluation (knee pain and five of the following: over 50 years of age, less than 30 minutes of morning joint stiffness, bone fragility, bone enlargement, joint heat, crackling to active movement."	Presence of autoimmune diseases; Open wounds or skin lesions in the knee region; Chronic diffuse pain (fibromyalgia); Cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-89489x	Possible Effects of the Use of Silicon Oxide Pads in Cases of Cervical Spine Pain in Academics of Dentistry	Data analysis completed	Intervention	2019-09-24	<NULL>	<NULL>	2994	Possible Effects of Stiperterapia in Cases of Pain in the Cervical Spine in Academics of Dentistry	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-89489x	<NULL>	"Academic students enrolled in Unisul&apos;s Dentistry course and attending the 5th to 10th phase that corresponds to the period of clinical practice and present a complaint of cervicalgia;
Age from 19 years."	"To present injury due to trauma or disc herniation in the cervical region;
Have a history of allergy or tape intolerance;
Present any skin lesion in the area corresponding to the cervical / scapular region;
Continued or frequent use of analgesic or myorelaxant medications;
Being in physical therapy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-4nmdwr	Effects of pecan nut consumption on the metabolism of adults with Obesity	Recruitment completed	Intervention	2019-09-24	<NULL>	<NULL>	2995	Metabolic effects of pecan nut consumption in adults with Obesity: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4nmdwr	<NULL>	Volunteers aged 20 to 59 years; body mass index (BMI) equal to or greater than 30 kg / m² due to excess body fat; who agreed to participate voluntarily in the study; and that they would be willing to follow the proposed recommendations.	Participants with: 1) psychiatric disorders, history of cancer, endocrine disorders (adrenal diseases, thyroid diseases, polycystic ovarian syndrome, diabetes mellitus and dyslipidemia in drug and non-drug treatment), spoliation status (fever, malabsorption syndrome, surgery), inflammatory, infectious, autoimmune, renal, cardiovascular, hepatic (cirrhosis, hepatitis, and hepatic insufficiency) diseases; 2) use of weight-loss, appetite-suppressing, immunosuppressive, anti-inflammatory, corticosteroid, antibiotic, hypolipidemic, antidiabetic, anticoagulant, antihypertensive, hormonal (except stable contraceptive use for at least 6 months); 3) frequent consumption of nuts, including peanuts and baru almonds (one or more times in the week); 4) allergy or food intolerance to any type of nuts (including peanuts or baru almonds); 5) use of dietary supplements; 6) alcoholics, smokers or drug abuse; 7) women in climacteric, pregnant and nursing mothers; 8) performing restrictive diet or dietary treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-66359j	Evaluation of inhaled medications to improve breathing during exercise in patients with Pulmonary Arterial Hypertension	Not yet recruiting	Intervention	2019-09-25	<NULL>	<NULL>	2996	Evaluation of inhalation inteventions to attenuate the abnormalities of respiratory mechanics during patient&apos;s exercise whit pulmonary arterial hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa e Eventos (FIPE)	https://ensaiosclinicos.gov.br/rg/RBR-66359j	<NULL>	Patients diagnosed with pulmonary arterial hypertension according to the Nice classification, 2013, confirmed by right cardiac catheterization at rest. Stable drug treatment in the last 3 months. Symptomatic, with dyspnoea. In functional class of the New York Heart Association II and III.	Non-HAP Pulmonary Hypertension, that is, Groups 2 to 5 will be excluded, as well as patients with other comorbidities that may cause limitation of exercise capacity. Use of prolonged home oxygen therapy. That they present FEV1VF &lt;0.7. Be involved in regular physical activity programs in the last 3 to 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-6qzktx	Sensitivity after posterior restorations: clinical trial using a Glutaraldeyhe-based desensitizer	Recruitment completed	Intervention	2019-09-25	<NULL>	<NULL>	2997	Post-operative sensitivity in posterior composite restorations: a double-blind randomized clinical trial of a Glutaraldeyhe-based desensitizer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6qzktx	<NULL>	Age: between 18-50 years old; have at least four carious lesions and / or indications for restoration replacement (fracture, secondary caries, provisional restoration), with a depth higher than or equal to 3 mm measured from the central sulcus; the teeth to be restored must be vital and in occlusion with the antagonist	Severe or chronic periodontitis; parafunctional habits; continued use of medication that may alter pain perception (analgesic, anti-inflammatory); patient under whitening treatment; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-9mfcyv	Estudo clínico da efetividade de sabonetes líquidos desinfetantes no controle da placa bacteriana presente em dentaduras	Data analysis completed	Intervention	2019-09-26	<NULL>	<NULL>	2998	"Estudo clínico da efetividade de sabonetes líquidos desinfetantes no controle do
biofilme presente em próteses totais"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Faculdade de Odontologia de Araraquara	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9mfcyv	<NULL>	Be between 45 and 80 years old; To be a user of superior removable total dentures;  Do not use any chemical cleaning agent on your dentures during the period of the research and at least 3 months; Present normal salivary flow with mean of 0.7 mL / minute and at least 0.5 mL / minute; Show good general health for at least 6 months; The total dentures should be able to be used (with stability, without fractures and without the presence of repacking material); The prosthesis should not be more than 5 years old.	Whose prosthesis presents problems in the adaptation, need of relining, repairs and or fractures; With systemic infectious diseases (hepatitis, AIDS) or local; That they present oral Candidosis at any level according to the modified Newton classification; With serious and limiting diseases; In the treatment of malignancies or who use immunosuppressive, systemic antibiotic and / or antifungal medicines in the three months prior to the study; With special needs, physical disabilities, or with committed manual dexterity; Smokers; Diabetics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-8kwxbg	The intervention of Restricted Therapy in children with Paralyzed Upper Limb	Recruitment completed	Intervention	2019-09-26	<NULL>	<NULL>	2999	"The intervention of Induced Congestion Therapy in children with Brachial Palsy
Obstetric: a blind, controlled and randomized study"	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Associação de assistência á criança deficiente	Associação de assistência á criança deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8kwxbg	<NULL>	Diagnosis of Obstetric Brachial Paralysis of the Erb-Duchene or Klumpke type; Both genders and age between 4 and 8 years; Be able to respond cognitively to the commands requested by the therapist; To be able to attend the care association for disabled children Ibirapuera for 3 weeks for 3 hours / day; Motorally be able to perform active movement of the MSA at least 45 degrees of shoulder flexion and abduction; 20 degrees elbow extension; 10 degrees of wrist extension and three finger movement and including the thumb.	Diagnosis of obsteric brachial palsy Complete; Perform motor therapy with occupational therapy or aquatic physiotherapy during the intervention period; Present musculoskeletal deformity that reduces the range of motion of the affected upper limb in each joint with shoulder or elbow or wrist by more than 10 degrees always considering the expected normal value.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-39jnp4	Caffeine&apos;s Effects on improving Physical Performance	Recruitment completed	Intervention	2019-09-26	<NULL>	<NULL>	3000	The biology of Ergogenic Caffeine Effects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-39jnp4	<NULL>	Healthy subjects; male; age between 18 and 25 years; do not practice physical activities regularly. more than 150 minutes per week.	Lumbar disease; cardiac arrhythmia; convulsion; gastric problems; use of nutritional supplements or ergogenic aids; structural or functional deformities; cognitive problems; smoking; use of tricyclic antidepressants; use of caffeine-containing medicines; hypertension; diabetes; BMI over 25; phobia for blood collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-9p66gk	Nutritional follow-up in radiotherapy patients	Data analysis completed	Intervention	2019-09-26	<NULL>	<NULL>	3001	Nutritional follow-up in patients with head, neck and esophageal Cancer undergoing radiotherapy treatment (chemo)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Sheila Cristina Pootz	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9p66gk	<NULL>	Diagnosis of head and neck or esophageal cancer; individual does not have another catabolic disease such as HIV or cirrhosis; both genders; age between 18 and 100 years.	Age under 18 years; carrier of another catabolic disease such as cirrhosis or HIV; tumor located in different region of head and neck or esophagus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-3p3nz8	Effect of an interdisciplinary treatment on the consumption of industrialized foods in overweight women.	Recruiting	Intervention	2019-09-26	<NULL>	<NULL>	3002	Effect of an interdisciplinary intervention on the consumption of ultra-processed foods in overweight women.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Ana Paula Grotti Clemente	Ana Paula Grotti Clemente	https://ensaiosclinicos.gov.br/rg/RBR-3p3nz8	<NULL>	"Intervention Group: Women; aged 19 to 45 years; overweight; residents of Denisson Menezes or its surroundings; among the first 55 people to appear at the service with interest to participate in the protocol.
Control Group: Women aged 19 to 45 years old; overweight; residents of Denisson Menezes or its surroundings; between position 56 and 110 of the list of interested subscribers to participate in the study."	Women who have previously taken anabolic androgenic steroids or psychotropic drugs; pregnant women; lactating women; and individuals who have experienced morbid resulted in prolonged hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-54c7zt	Effect of different Periodontal Maintenance intervals on the perimplant biological complications.	Recruitment completed	Intervention	2019-09-26	<NULL>	<NULL>	3003	Effect of different Supportive Periodontal Therapy protocols on the incidence of perimplant biological complications.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-54c7zt	<NULL>	to be 40 to 60 years old; to smoke at least 20 cigarrets a day; to have at least 20 teeth; to present more than 20 % of sites with clinical attachment loss  greater than 6 mm and probing pocket depth greater than 5 mm, bleeding on probing. The affected teeth should present more than 30 % of alveolar bone loss; to have lost one or two teeth which need to be replaced by implant supported protheses; to read and sign an informed consent to this study protocol.	need of antibiotic prophylaxis for surgical procedures; history of antibiotics or periodontal therapy in the last six months; use of long term antiinflammatory drugs; history of cronic diseases which could interfere with the course of periodontal diseases, including diabetes, rheumatoid arthritis, immunodeficiencies; pregnancy or nursing; need of alveolar bone regeneration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-3rs7sx	Educational actions on breastfeeding for pregnant women in limoeiro do norte	Recruitment completed	Intervention	2019-09-27	<NULL>	<NULL>	3004	Health education in the first quarter of pregnancy: promoting breastfeeding among pregnant women in limoeiro	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Instituto Federal de Educação, Ciência e Tecnologia do Ceará	Instituto Federal de Educação, Ciência e Tecnologia do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3rs7sx	<NULL>	be pregnant in adulthood, from 19 years and up to 50 years; be in the first trimester of pregnancy. perform prenatal care at one of the ten basic health units in limoeiro do norte-ce.	pregnant women who answered the knowledge evaluation form incomplete; who gave up before the end of the educational activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-6n4q8v	Effect of early intervention program for premature babies who were hospitalized in the Neonatal Intensive Care Unit	Recruitment completed	Intervention	2019-09-27	<NULL>	<NULL>	3005	Effect of a family-centred intervention program on motor and cognitive development of preterm infant of Neonatal Intensive Care Unit: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-6n4q8v	<NULL>	Infants born preterm (IG below 37 weeks) who are admitted to the neonatal intensive care unit after birth, without congenital orthopedic or central nervous system malformations, and whose parents or guardians sign the Inform Consent forms. The babies should be evaluated after hospital discharge; not exceeding 3 weeks corrected age or 43 weeks postconceptional age	Infants who were born term or post-term (IG above 38 weeks) or preterm infants who were not hospitalized in the Neonatal Intensive Care Unit after birth with congenital orthopedic or central nervous system malformations will be considered as exclusion criteria for the study. whose parents or guardians do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-65q4hg	Effect of vitamin C supplementation on children with Osteogenesis Imperfecta	Data analysis completed	Intervention	2019-09-27	<NULL>	<NULL>	3006	Evaluation of musculoskeletal pain and collagen production in patients with vitamin C supplemented osteogenesis imperfecta: pilot study of a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-65q4hg	<NULL>	Patients with OI (types I, III and IV) and without other associated diseases. Age range from zero to 18 years. Patients who underwent intravenous disodium pamidronate treatment cycles at the HIJG every 2, 3, 4, or 6 months between January and December 2018. Patients who had conditions for oral medication administration. Patients who do not use continuous analgesics, continuous anti-inflammatory drugs or antidepressants for pain control or other medical indication.	PParticipants who did not attend the hospital for disodium pamidronate administration. Participants who presented temporary or permanent suspension of disodium pamidronate administration during the data collection period. Participants who did not have blood samples collected during the first or second data collection. Participants who did not return for the second data collection. Participants who used continuous analgesics, continuous anti-inflammatory drugs and antidepressants for pain control or other medical indication after the first data collection. Participants reporting inadequate vitamin C supplementation between data collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-4bhxpb	Randomized clinical study on the performance of materials for the treatment of sensitive teeth due to enamel stains.	Recruiting	Intervention	2019-09-27	<NULL>	<NULL>	3007	Randomized clinical trial of the performance of materials for treatment of hypersensitivity caused by Molar Incisor Hypomineralization (HMI).	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-09	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-4bhxpb	<NULL>	Children born in Bauru aged between 6 and 10 years old students from public schools;Teeth with HMI without loss of structure; Tooth with HMI without caries lesion;Tooth with HMI and sensitivity	Children with syndromes related to enamel malformation;Children who do not collaborate with the exam due to misbehavior;Children with orthodontic appliances at the clinical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-48tw95	The effect of protein amount on food for ICU cancer patients	Recruiting	Intervention	2019-09-27	<NULL>	<NULL>	3008	The effect of Protein supply on critical cancer patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-48tw95	<NULL>	Older than 18 years; patients who remain in the ICU for up to 7 days; use of enteral and / or parenteral nutritional therapy.	Under 18 years old; patients on end-of-life care or withdrawal of life support treatments within 7 days of inclusion; pregnant; contraindication of protein supply by the medical care team; acute or chronic kidney injury; dialysis dependence; acute or chronic liver failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-5cfqyw	Skeletal and dental arch changes following rapid maxillary expansion: a prospective randomized controlled study	Recruitment completed	Intervention	2017-08-17	<NULL>	<NULL>	3009	Skeletal and dental arch changes following rapid maxillary expansion: a prospective randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-22	Universidade Norte do Paraná (UNOPAR)	Universidade Norte do Paraná (UNOPAR)	https://ensaiosclinicos.gov.br/rg/RBR-5cfqyw	<NULL>	"Patients with Angle Class I malocclusion and cross-bite or maxillary atresia;
Patients with mixed dentition and acceptable oral health;
Patients aged 7 -10 years , with first permanent molars in occlusion;
Caucasian;
Absence of agenesis, loss of permanent teeth and supernumerary teeth."	Patients that had undergone orthodontic treatment or had a syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-3wrnrf	Effect of fibers on intestinal transit and inflammation of patients with Pre-Dialytic Chronic Renal Disease	Not yet recruiting	Intervention	2019-09-28	<NULL>	<NULL>	3010	Effect of prebiotics on intestinal transit and inflammation profile of patients with Pre-Dialytic Chronic Renal Disease.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-3wrnrf	<NULL>	Patients with non-dialytic stage V chronic kidney disease; over 18 years of age; who do not have gastroenterological pathologies; do not have cancer; and do not use continuous laxatives	Patients younger than 18 years of age; with gastroenterological pathologies; pregnant women of any gestational age; cancer; patients on continuous use of laxatives; patients with CKD of any other stage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-22md2n	Influence of chitosan gel on dentin erosion. Clinical and photographic evaluation of restorative teeth	Recruitment completed	Intervention	2019-09-28	<NULL>	<NULL>	3011	Influence of chitosan on the biomodification of eroded dentin. Clinical and photographic longitudinal analysis of restorations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-22md2n	<NULL>	Patients selected should be 18 to 60 years old. The criterion of inclusion of the patient will be the presence of at least two erosive lesions, located on the palatine or lingual surface of homologous teeth with pulp vitality. The teeth should have a positive response to the thermal test performed with Endofrost (Roeko, Langenau, Germany).	Will be excluded from the research the patients who present teeth with pain and / or spontaneous sensitivity, fistula and / or edema	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-4vr87t	Effects of combining Dry Needling and Therapeutic Ultrasound on the treatment of neck muscle tension points	Recruitment completed	Intervention	2019-09-30	<NULL>	<NULL>	3012	"Effects of the combination of Dry Needling and Therapeutic Ultrasound on the treatment of
Trigger Points in the upper trapezius muscle"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Centro Universitário de Anápolis	Centro Universitário de Anápolis	https://ensaiosclinicos.gov.br/rg/RBR-4vr87t	<NULL>	Young adults with active or latent trigger point (PG) in the upper trapezius muscle aged between 18 and 50 years old; with complaints of pain over three months were included. To confirm the diagnosis of myofascial PG; the following criteria were require; a palpable tense band in the upper trapezius muscle; range of motion limitation; a point sensitive to palpation and pain referred local or in specific areas according to the evaluated muscle	Participants diagnosed with fibromyalgia; radiculopathy; myelopathy; cervical vertebral fractures; needle phobia; coagulation disorder; muscular derelaxants; and physical therapy in the last three months in the cervical region will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-5n32n5	Evaluation of application protocol for at-home bleaching with 4% Hydrogen Peroxide	Recruitment completed	Intervention	2019-09-30	<NULL>	<NULL>	3013	Evaluation of application protocol of the 4% Hydrogen Peroxide for at-home bleaching - a randomized double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5n32n5	<NULL>	At least 18 years old; good general and oral health; absence of caries and restorations in the anterior superior teeth; upper canines showing color A2 or darker according to color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany).	Use of dental prosthesis or orthodontic appliances; have deep dental stains (tetracycline and fluorosis stains); pregnant or lactating women; volunteers with any other pathology that may cause sensitivity (such as recession, dentin exposure or the presence of visible cracks in the teeth); parafunctional habits, volunteers who have already undergone tooth whitening procedures or who have previous spontaneous hypersensitivity; to make continuous use of medications that may alter pain perception (painkillers and anti-inflammatory drugs).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-72j2yh	Influence of treatment directed to pregnant women on smoking cessation during pregnancy and after delivery	Recruitment completed	Intervention	2019-10-01	<NULL>	<NULL>	3014	Influence of brief intervention directed to pregnant women on smoking cessation during pregnancy and after delivery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-72j2yh	<NULL>	Pregnant womem; current smokers; age between 14 and 45 years	No pregnant womem; never smoking or former smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-7mf794	Result of action to increase acceptance and adhesion to school feeding in the city of Sumidouro-RJ	Recruiting	Intervention	2019-02-26	<NULL>	<NULL>	3015	"Impact of intervention aiming for greater acceptance and adhesion to school feeding:
community-based trial in Sumidouro - RJ"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade do Estado do Rio de Janeiro - Instituto de Medicina Social	Universidade do Estado do Rio de Janeiro - Instituto de Medicina Social	https://ensaiosclinicos.gov.br/rg/RBR-7mf794	<NULL>	Healthy volunteers; both genders; age between 8 and 19 years; be regularly enrolled in the schools participating in the study; sign the &quot;Term of Assent&quot;; return of the &quot;Free and Informed Consent Form&quot; signed by parents and / or guardians.	Age less than 8 years and greater than 19 years; not be regularly enrolled in the schools participating in the study; not agree to sign the &quot;Term of Assent&quot;; not to return the &quot;Free and Informed Consent Form&quot; signed by parents and / or guardians.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-263wr8	Immediate effects of different Physical Therapy Techniques in the Balance of non-exercising elderly women	Not yet recruiting	Intervention	2019-10-01	<NULL>	<NULL>	3016	Acute Effects of different stabilization techniques of Proprioceptive Neuromuscular Facilitation on the Balance of Sedentary Elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESCOLA DE EDUCAÇÃO FÍSICA FISIOTERAPIA E DANÇA	UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESCOLA DE EDUCAÇÃO FÍSICA FISIOTERAPIA E DANÇA	https://ensaiosclinicos.gov.br/rg/RBR-263wr8	<NULL>	Women who are 70 years of age or older will be included in the study. That they do not perform regular physical exercises and that they do not present chronic labyrinthitis; diseases of the central nervous system such as multiple sclerosis and cerebral palsy; abnormalities of the spinal cord such as trauma or degeneration of the spinal cord; peripheral nerve diseases such as peripheral neuropathy; degenerative muscular diseases like muscular dystrophy; myotonic dystrophy and myositis; skeletal abnormalities and diseases such as skeletal dysplasia and chondrodystrophy; blindness; Parkinson&apos;s disease; stroke with sequelae of spasticity or hypotonia.	Older people who are not able to perform the tests proposed during the evaluations will be excluded from the counting and statistical procedure of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-7x8tbx	Effect of Omega-3 on Blood Inflammation in Overweight and Liver Fat Patients	Recruitment completed	Intervention	2019-10-01	<NULL>	<NULL>	3017	Mechanism of ômega-3 fatty acids in the inflammatory process via GPR120 in blood cells of Overweight individuals with Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-05	FCA Unicamp	UNiversidade federal de sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7x8tbx	<NULL>	Patients with excess body weight (body mass index (BMI) greater than or equal to 25.0 kg / m2) between the ages of 19 and 75, of both sexes, diagnosed by the physician of the Hospital Universitário, Universidade Federal de Sergipe, Hepatology Outpatient Clinic with fNon-alcoholic fatty liver disease (NAFLD), as a result of the presence of fat in the liver by ultrasonography, negative serological results for hepatitis B and C, absence of autoimmune diseases, absence of current or previous clinical history of alcohol abuse, absence of other liver diseases caused toxins or metabolites (eg corticosteroids, high doses of estrogen, methotrexate, tetracycline, calcium channel blockers, amiodarone or tamoxifen). The patients should be residents of the Aracaju Metropolitan Region, which is composed by the cities of Aracaju, Nossa Senhora do Socorro, Barra dos Coqueiros and São Cristovão.	Patients pregnant, nursing, allergic to fish and crustaceans, smokers, carriers of diseases that can lead to change in body weight such as hypo or hyperthyroidism, hypogonadism, hyperandrongenism in women, Cushing&apos;s syndrome and other types of secondary obesity, as well chronic kidney disease, cancers and inflammatory bowel disease. Also excluded are individuals taking anti-inflammatory drugs and who in the last three months prior to the study made use of nutritional supplements such as vitamins, minerals, oils and fats or those who are doing some treatment for weight loss and those who have lost more than 10% body weight in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-6vjhrs	Immediate and late effect of cryotherapy on balance, proprioception and muscle activity in healthy young men	Recruitment completed	Intervention	2019-10-01	<NULL>	<NULL>	3018	Immediate and late effect of cryotherapy on the static balance, the joint position sense and the electromyographic activity in young and healthy men	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidad Industrial de Santander	Universidad Industrial de Santander	https://ensaiosclinicos.gov.br/rg/RBR-6vjhrs	<NULL>	Male students; age between 18 and 25 years old.	Participants with no previous history of musculoskeletal; or neurological lesions; alterations in the vestibular system; Raynaud&apos;s phenomenon; or any medical condition that may affect the balance in the standing position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-54xy8b	Efficacy of tylex-associated to a desensitizer in tooth sensitivity induced by office bleaching	Not yet recruiting	Intervention	2019-10-01	<NULL>	<NULL>	3019	Efficacy of codeine/paracetamol-associated to a desensitizer in tooth sensitivity induced by office bleaching: a randomized, controlled, triple-blind clinical trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-54xy8b	<NULL>	Patients should be at least 18 years of age; good general and oral health; upper anterior teeth with no restorations; never bleached before.	Patients who present previous restorations; pregnant or breastfeeding; have discoloration of the dental element caused by trauma; severe fluorosis; darkening caused by endodontic treatment and requiring internal bleaching (non-vital); habits of bruxism or without good oral health; any previous or current health problems (in the stomach, heart, kidney and liver); continuous use of anti-inflammatory drugs and/or analgesics; systemic diseases such as diabetes, hypertension; known allergy to codeine phosphate 30mg/paracetamol 500mg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-336mnh	Clinical and radiographic evaluation of the efficacy of pulpal revitalization treatment: randomized clinical trial	Recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3020	Clinical and radiographic evaluation of the efficacy of the application of an enamel matrix derivative (Emdogain) in regenerative endodontics: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-08	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-336mnh	<NULL>	"To be eligible in this study it will be necessary for patients to have the following characteristics:
Patient who volunteers to participate in the study, in the age group of 8 to 15 years; Possess at least one tooth with open apex and pulp necrosis with or without periapical lesion; Radiographic examination showing open apex with 2 mm diameter;
Healthy patient with absence of known allergies to the medicines used in the procedure, immune or systemic disease"	Tooth with closed apex, apical cysts and existing disease requiring long-term anti-inflammatory treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-9s8yt9	Assessment of muscle stress in patients with moderate to severe COPD	Recruitment completed	Intervention	2019-10-02	<NULL>	<NULL>	3021	Assessment of muscle stress in patients with moderate to severe COPD	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-16	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-9s8yt9	<NULL>	Inclusion criteria were sedentary patients with moderate to severe COPD diagnosed according to the GOLD criteria, who did not engage in any clinically stable physical activity.	We excluded oxygen-dependent patients with a locomotor or neurological disorder and clinical instability, such as an indication of changes in treatment regimen or exacerbation of any severity in the previous 12 weeks and concomitant diagnosis of malignant diseases, chronic heart failure, liver disease or neuropathy, or actively engaged in any physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-7bn9gc	Reduction of preoperative fasting time on scheduled cesarean section	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3022	Abreviation of the fasting pre-operative in the cesarean elective	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Hospital Universitário Julio Müller HUJM	Universidade Federal de Mato Grosso UFMT	https://ensaiosclinicos.gov.br/rg/RBR-7bn9gc	<NULL>	Women 18 to 40 years of age; above 39 gestational weeks Present body mass index (BMI kg / m²) suitable for gestational age according to the chart of Atalah et al 1997 Single fetus Elective caesarean with wall opening abdominal pain by the Pfannenstiel technique Present ASA (American Society of Anesthesiologist) score I and II Be submitted to the regional anesthetic technique; Ability to understand the rationale of the study evaluations; Signed the free and informed consent form.	Patients who do not adhere to the protocol at any stage of the study and who present: Anemia (Hb &lt;11.0 g / dL); Gestational Diabetes (Fasting glycemia above 95 mg / dL by the TGO reference value: (&gt; 140/90 mmHg); Renal or hepatic disease; C-reactive protein&gt; 6.0 mg / L; Clinical repercussion of gastroesophageal reflux for the gravidic condition (Hyperemesis gravidarum, abnormal anatomy of the upper gastrointestinal tract); Operating time greater than two hours; Blood collection in the non-scheduled period; Preoperative complications requiring an emergency or major intraoperative cesarean section (eg hemorrhage).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-2kkb6d	Analysis of the effectiveness of cinnamon in the reduction of sugar and fat levels of adults with type 2 Diabetes	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3023	Analysis of the effectiveness of cinnamon (Cinnamomum verum) in the reduction of glycemic and lipidic levels of adults with type 2 Diabetes	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2kkb6d	<NULL>	Volunteers of both genders; aged between 18 and 80 years; diagnosis of type 2 diabetes confirmed for at least five years; taking oral antidiabetics; with HbA1c values between 6.5 and 8.0%; preserved cognitive functions.	Volunteers with cinnamon allergy; Patients who use another herbal medicine for diabetes treatment; Patients using cinnamon for diabetes treatment; Patients diagnosed with alcoholic liver disease, cirrhosis or abnormal basal liver function; Patients on insulin therapy; Women breastfeeding, pregnant or on contraceptives; Patients with heart, liver or respiratory failure; Patients with bleeding disorders and who are taking coumarin derivatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-8w44f6	Clinical trial of the effect of breathing exercise on expiratory force and abdominal muscle in stroke patients	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3024	Effect of Respiratory Muscle Training on expiratory muscle strength and abdominal electrical activity in the acute phase of Stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP	lorena	https://ensaiosclinicos.gov.br/rg/RBR-8w44f6	<NULL>	Patients aged 18 years and under 80 years of age admitted to the stroke unit of the Clinical Hospital of the Botucatu Medical School, with clinical diagnosis of ischemic stroke by magnetic resonance or computed tomography with up to 80 years will be evaluated. 72 hours of the ictus, absence of disability prior to hospitalization with score less than or equal to 1 in eMR, item 1a (level of consciousness), 1c (Commands: open / close eyes, shake and release hand), language and facial paresis NIHSS less than equal to 1, no previous dementia or other associated neuromuscular diseases, no severe valvulopathy and previous major thoracic or abdominal surgery under 1 year, no congestive heart failure class III and IV, no asthma or decompensated chronic obstructive pulmonary disease (COPD) with a closed diagnosis.	Patients with previous complaints of dysphagia, clinical instability, invasive mechanical ventilation or palliative care will be excluded, those who fail to perform the MIP / MEP assessment protocol, ventilometry, non-adaptation to training, worsening of clinical and hemodynamic status and those who do not agree to participate in the study or refuse to continue the training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-62sxcr	The Bad Ragaz Method On The Functionality Of Diabetic	Data analysis completed	Intervention	2019-09-17	<NULL>	<NULL>	3025	Effect Of The Bad Ragaz Method On The Functionality Of Diabetic Elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	UNIVERSIDADE FEDERAL DO PIAUÍ	UNIVERSIDADE FEDERAL DO PIAUÍ	https://ensaiosclinicos.gov.br/rg/RBR-62sxcr	<NULL>	"The research will include the elderly in the clinical sector physiotherapy school in the
between 60 and 80 years of age; regardless of gender; those who agreed to participate in the
research through the signing of the informed consent form (TCLE)."	"Will be excluded from the research the gerontans who present psychiatric disorder;
injuries; metabolic decompensation; labyrinthitis; otitis; low cognition; second
advocated by the Ministry of Health, through the Mimi Mental State Examination (BRASIL,
2006) or those who withdraw their consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-85fsrb	Folic acid excess: effects on vitamins B2 and B6 concentrations, tryptophan and immune system	Data analysis completed	Intervention	2019-10-03	<NULL>	<NULL>	3026	Folic acid excess: effects on vitamins B2 and B6 metabolism, tryptophan catabolism and immune response	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85fsrb	<NULL>	Healthy subjects; both sexes; aged between 18 and 45 years	Individuals under 18 years, chronic alcoholics; patients with acute or chronic diseases; pregnant women; users of immunossupressive medications, vitamins or vitamin supplements; blood donors in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-8xyzjg	Evaluation of Laser Application in Bone Healing after tooth removal in Head and Neck Radiotherapy patients	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3027	Evaluation of Photobiomodulation in Bone Repair after tooth extraction in patients submitted to Head and Neck Radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xyzjg	<NULL>	Individuals aged 18 to 79 years with a history of OSCC of any region of the oral cavity who have been treated with conformational radiotherapy (3DRT) exclusively or not for at least 1 year and who present teeth with need for extraction in the maxilla or mandible included in the radiation field.	Individuals undergoing oncologic treatment or with relapse of the lesion, as well as pregnant women; infants and patients under 18 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-3r3mqw	Effects of a containing ora-pro-nobis product on the gut and anthropometric data in adults	Data analysis completed	Intervention	2019-10-03	<NULL>	<NULL>	3028	Development of containing Ora-Pro-Nobis (Pereskia aculeata Mill.) Product and its influence on intestinal microbiota, antioxidant capacity, anti-inflammatory, biochemical and anthropometric parameters in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3r3mqw	<NULL>	Women, aged between 20 and 60 years. Fat percentage above 25%. Not having participated in weight loss program in the last six months; Be healthy.	"Have a diagnosis of autoimmune, endocrine, cardiac, cerebrovascular, renal, hepatic, gout, gastrointestinal, inflammatory and / or infectious diseases;
have made use of dietary supplements, laxatives and antibiotics in the last six months;
have undergone surgery in the last six months;
have made regular use of alcohol, cigarettes and other drugs in the last year;
be vegetarian;
being on herbal remedies or preparations;
exhibit allergic reactions to product components;
be pregnant or nursing;
have ingested probiotic in the last year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-2b8qtg	Effect of a single phototherapy session on lower limb muscle fatigue	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3029	Single-session temporal effect of cluster phototherapy on lower limb muscle fatigue in sedentary young adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-2b8qtg	<NULL>	healthy; sedentary; volunteers	Neurological and cognitive impairment; cardiorespiratory diseases and history of joint and muscle injury in the last six months; muscle and joint injury; or absences during specific evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-9d8cxh	Pain perception during Cleaning of dental roots in patients with systemic chronic diseases using Local Anesthesia	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3030	Pain perception during Scaling and Root Planing in patients with systemic chronic diseases using Local Anesthesia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-06-01	Curso de Odontologia - Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9d8cxh	<NULL>	Patients with mild to severe localized / generalized periodontal disease (stage I to IV, classification 2018) with 4 sites with probing depth measurements greater than 4mm in at least two teeth per quadrant,   with clinical attachment loss greater than  1mm, presence of supra and subgingival calculus and / or dental biofilm as well as presence of bleeding on probing and / or marginal suppuration; over 18 years old; being under medical supervision due to chronic diseases (pulmonary, cardiovascular and metabolic).	Patients in periodontal or orthodontic maintenance; history of allergy, sensitivity or any form of allergic reaction to amide-based anesthetics; pregnant or lactating women; patients with severe uncontrolled systemic disease and without specialized medical follow-up; psychiatric problems that may interfere with scaling and root planing or administration of topical anesthetics and injectables; local pathological alterations such as presence of ulcerative lesions, abscesses, acute infections; volunteers who require dental extraction in the selected quadrants; need for antibiotic prophylaxis prior to treatment; patients who used analgesic and anti-inflammatory drugs within 12 hours prior to treatment; individuals with a history of alcoholism; smokers; dentin hypersensitivity or other pulp pathologies that may interfere in the measurement of the data in the teeth involved in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-7bd3xy	Oxygen therapy under pressure facilitates the healing of chronic wounds on the feet of diabetic patients	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3031	Hyperbaric oxygen therapy facilitates the healing of chronic wounds on the feet of diabetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-04	Faculdade de Medicina do ABC - SP	Faculdade de Medicina do ABC - SP	https://ensaiosclinicos.gov.br/rg/RBR-7bd3xy	<NULL>	Adult patients (age greater than18 years); Stable clinical condition; Diabetes type 1 and 2 ; Foot wounds with Grade 2, 3 and 4 of Wagner; Lesions with more than 1 month, uncured; Authorization for the study; Patients of the SUS(Single Health System) .	Failure to fulfill one of the inclusion criteria; Patients who have contraindications for  hyperbaric oxygen therapy, absolute or relative: chemotherapy with bleomycin, chronic obstructive pulmonary disease, prior spontaneous pneumothorax, chronic sinusitis, chronic media otitis , unstable angina, severe congestive heart failure, claustrophobia, severe dementia, depression and history of seizures; Patients with macroangiopathy (absent of distal pulses).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-6yg2z9	Immunoprophylaxis with BCG vaccine combined with the use of rifampicin in a single dose in contacts less than 15 years old at home of patients with Leprosy	Not yet recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3032	Immunochemioprophylaxis in the prevention of Leprosy contacts in children under 15 years of age	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Mato Grosso	Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-6yg2z9	<NULL>	Individuals younger than 15 years (5 years to 14 years, 11 months and 29 days); household contacts of new leprosy cases diagnosed and registered in the National Notification of Injury Information System (SINAN/MT) in 2018 (treatment or treatment virgin) up to 4 weeks of MDT use) of both sexes; who resided or resided within five years before/during the diagnosis of the index case.	It is those who refuse to undergo the clinical examination; who are diagnosed with leprosy during the examination; those who have a history of hypersensitivity after the previous dose of the vaccine or any component of the vaccine; pregnant women, patients receiving high dose corticosteroids ( 2 mg/kg/day for children up to 10 kg or 20 mg/kg/day for individuals over 10 kg) for a period of more than two weeks; patients taking other immunosuppressive therapies (antineoplastic chemotherapy, radiotherapy, among others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-3hknrw	Effect of a Diet with fewer Calories and a low-Meat diet in the metabolism of humans	Recruiting	Intervention	2018-07-26	<NULL>	<NULL>	3033	Study of the metabolic and molecular changes involved in Caloric Restriction and in the Hypoprotein Diet in humans	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-10	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3hknrw	<NULL>	Volunteers of both genders; non smokers; age between 30 and 60 years who present type 2 diabetes mellitus, who do not use insulin and who present dyslipidemia.	Volunteers with BMI above 35, smokers and who use insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-4hhwjb	Evaluation of denture cleansers. A clinical trial.	Recruiting	Intervention	2018-11-09	<NULL>	<NULL>	3034	Hygiene protocols for the treatment of Denture-related stomatitis, analysis of local and systemic parameters: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4hhwjb	<NULL>	Patients can be of both genders; general good health status; bear superior complete dentures in good condition; phosthesis mades in thermally polymerized acrylic resin and acrylic teeth; present regular hygiene habits; present DS pictures between types IB, II or III; a level that is perceptible to severe halitosis and odor of the prosthesis; the prosthesis should present biofilm with a score equal to or greater than 1 according to the Additive Index.	Presenting a prosthesis with problems of adaptation; with relinizations; repairs or fractures; present allergy to any of the products studied; chronic non-controlled diseases; infectious diseases; have used some medicines such as antibiotics, antifungals, immunosuppressants, anticoagulants and steroids during the last 3 months; have used mouthwash solutions in the last 15 days prior to the survey; does not possess enough manual dexterity to perform the hygiene of the prostheses and the cavity; do not understand the Portuguese language; have cognitive problems that may interfere with compliance with the guidelines provided.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-2vj7sw	Analysis of the evolution of patients with Chronic Cervicalgia as a function of the Treatment of Choice.	Data analysis completed	Intervention	2019-01-02	<NULL>	<NULL>	3035	Analysis of the clinical evolution of the Patient with Non-specific Chronic Neck Pain as a Choice of Treatment Choice. A randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-2vj7sw	<NULL>	Current neck pain. Neck pain continued for at least the last twelve weeks.	Irradiated neck pain. Neck pain associated with dizziness. Osteoporosis. Psychological disorders. Vertebral fractures Tumors Metabolic diseases. Previous neck surgery Red Flags (Night pain, severe muscle spasm, loss of involuntary weight, symptom mismatch). Physiotherapeutic treatment continued in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-2q24nb	Manual and instrumental therapy for the treatment of women&apos;s neck pain	Recruiting	Intervention	2019-09-29	<NULL>	<NULL>	3036	Ischemic Compression in the Treatment of Myofascial Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-10	Universidade Federal de Santa Catarina- UFSC	Universidade Federal de Santa Catarina- UFSC	https://ensaiosclinicos.gov.br/rg/RBR-2q24nb	<NULL>	Present active trigger point in the upper trapezzius;present pain in the cervical region beginning within three months; present pain level greater than 3 in the visual analogue scale (VAS).	Present whiplash injury and / or cervical pathologies such as disc herniation or Thoracic Gorge Syndrome; be performing treatment for pain in the region of the neck and shoulders; make use analgesics, anti-inflammatory and / or muscle relaxant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-5dj3ym	Health Product Safety Assessment	Recruitment completed	Intervention	2019-09-30	<NULL>	<NULL>	3037	Evaluation of dermatological acceptability of health products under normal use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-10	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-5dj3ym	<NULL>	Female and male. Age 18 to 65 years. Phototype I to IV. Whole skin of the region. Occasional user of category products	"Cutaneous marks in the experimental area that interfere in the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scarring, increased hairiness, ephelides and nevus in large quantities, sunburns). Pregnant or nursing mothers. Participants with a history of allergy to the material used in the study.
History of atopy. Participants with a history of allergy to cosmetic products of the category tested. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use with corticosteroids in the experimental area up to 8 days before the start of the study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-8cb56q	Comparison between debriefing techniques for support diagnostic reasoning in nursing students	Not yet recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3038	Debriefing techniques as a help tool for diagnostic  reasoning of nursing students  randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Marcella Ferroni Gouvea	Marcella Ferroni Gouvea	https://ensaiosclinicos.gov.br/rg/RBR-8cb56q	<NULL>	Students registered in the second year of undergraduate Nursing course at the Federal University of Viçosa; and which are studying the discipline &quot;Nursing Skills II; both sexes; age  18 years old	It will be excluded from this study, students with training in other higher or technical courses in health; those who already have skill as a professional in the preparation of nursing diagnoses; who do not accept to participate in this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-2z7pkq	Effects of Neuromuscular Electrical Stimulation in Patients After Stroke	Recruitment completed	Intervention	2013-08-05	<NULL>	<NULL>	3039	Effects of Neuromuscular Electrical Stimulation in Patients After Stroke: Are There Evidences for Plasticity in The Spinal Cord Circuitry Associated With Spasticity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-10	Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	"Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista ""Julio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-2z7pkq	<NULL>	Will be included in the study, volunteers of both gender; with the diagnosis of stroke that may be hemorrhagic or ischemic, regardless of age. The stroke should have occurred for at least six months and spasticity of at least one point on the modified Ashworth scale.	Volunteers will be excluded from the study if they: Don´t have spasticity according to the Modified Ashworth Scale, present expression aphasia and comprehension (reported in medical records),cognitive and behavioral alteration (reported in medical records)and have a deficit of surface sensitivity (detected through assessment before the intervention).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-6y4r29	Comparison of thick and thin graft for root coverage	Recruitment completed	Intervention	2019-10-07	<NULL>	<NULL>	3040	The influence of subepithelial connective tissue graft thickness on root coverage outcomes. A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y4r29	<NULL>	Pacients non- smokers, age &gt; 18 years old, no systemic diseases or conditions that could affect periodontal health or healing ( ASA 1 or ASA2 Only), no Periodontal  Disease,  good oral hygiene (full mouth plaque index, and gingival index &lt; 20%), identifiable cementum-enamel junction and able and willing to provide informed consent for the surgery and study.	Voluntary withdrawal , Non compliance with study protocol, smokers or former smokers, pregnancy or lactation, previous surgical root coverage treatment , recession defects associates with caries or restoerations, history of destructive disease  in the area of interest, systemic healing disorders ( e.g., AIDS, diabetes mellitus,tooth with deep extensive erosion or abrasion, tooth severely malpositioned that may cause papillae height loss(i.e. malposition, rotations and versions, occlusal interferences or without antagonist)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-7292kp	Tongue tie: Speech therapy follow-up after surgery	Recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3041	Tongue frenulum: Speech therapy follow-up after surgical intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-05	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7292kp	<NULL>	Children with need to perform tongue frenulum surgery referred to the Child and Adolescent Clinic of the Faculty of Dentistry of UFRGS.	Children with head and neck malformations and cognitive changes;children who have already performed surgical procedure for the frenulum of the tongue; children who underwent or undergo speech therapy; children without upper and / or lower incisor teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-6kfbtt	Effects of physical therapy during hemodialysis in patients with chronic kidney disease.	Recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3042	Effects of a Respiratory and Motor Physiotherapy Protocol on Chronic Renal Patients During Hemodialysis: Randomized and Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade do Sul de Santa Catarina	Hospital Governador Celso Ramos	https://ensaiosclinicos.gov.br/rg/RBR-6kfbtt	<NULL>	Patients of both sexes; age between 19 and 75 years; diagnosis of chronic kidney disease and who have been on a regular hemodialysis program for at least three months.	Carriers of severe respiratory disease; neurological disease; severe heart disease; amputees; wheelchairs; presence of thrombosis; gastrointestinal bleeding; smokers; patients who perform previous regular physical activity or who perform physiotherapeutic intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-69pf3b	Study of dengue in a child population	Recruiting	Observational	2014-02-21	<NULL>	<NULL>	3043	Formation for a prospective cohort study of dengue in a child population	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-05-22	Instituto de Pesquisa Clínica Evandro Chagas	Instituto de Pesquisa Clínica Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-69pf3b	<NULL>	"pregnant women in the third trimester of pregnancy
living in Manguinhos"	"high-risk pregnancy
possibility of changing address"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-5t95n5	Comparison between different types of exercises to strengthen in patients with osteoarthritis of the knee	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	3044	Effect of strength training in different kinetic chains in pain, quality of life, the pattern of muscle recruitment during ascent and descent of stairs and joint position sense in patients with osteoarthritis of the knee	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-20	Universidade Federal de Uberlândia	Fundação de Apoio Universitário	https://ensaiosclinicos.gov.br/rg/RBR-5t95n5	<NULL>	Individuals of both sexes between 50 and 80 years, which presented diagnosis of osteoarthritis (OA) according to the criteria of the American College of Rheumatology, accompanied by radiological evidence, affecting one or more compartments of the knee, at the mild or moderate, with knee pain for six months or more and bilateral involvement.	Participants will have other musculoskeletal changes, chronic inflammatory diseases such as autoimmune diseases (rheumatoid arthritis, lupus, etc), diabetes mellitus, and neuromuscular disorders such as Parkinson&apos;s disease, vertigo and other conditions that may affect the sensory and control of movement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-5d25w3	Amazonian Oil intake on Metabolic Syndrome	Recruiting	Intervention	2019-10-08	<NULL>	<NULL>	3045	Effect of amazonian oil intake on Metabolic Syndrome patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Lívia Martins Costa e Silva	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5d25w3	<NULL>	Individuals between 30 and 65 years old; both genders; diagnosed with MS according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III, 2001); consulted at the Nutrition Clinic of the João de Barros Barreto University Hospital (HUJBB).	Patients with abnormal thyroid function; chronic kidney and / or liver disease; patients with neurodegenerative diseases such as dementia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-76cd72	Weight loss using different amounts of carbohydrates in the diet of fighters: impact on health and sports performance	Recruitment completed	Observational	2016-10-05	<NULL>	<NULL>	3046	Restricted energy for weight loss with different proportions of carbohydrates in the diet of fighters: impact on health and sports performance	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-08	Departamento de Nutrição da Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-76cd72	<NULL>	Being male; being over 18 and under 60 years old; are in off-season period; with over 5 years of practice in sport; 1.5 to 2h training / d and 4 to 5 times per week; have as a minimum graduation blue band; are from 4 to 10% of their body weight over the category in which they compete.	Recent weight loss history; conditions and / or are in medical or nutritional counseling for specialized treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-83ckh3	Comparison of drugs for anxiety relief before heart surgery	Data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	3047	Randomized blind prospective study: a comparison of midazolan, morphine or clonidine as premedication for cardiac surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-08-01	Instituto de Cardiologia do Rio Grande do Sul	Ari Tadeu Lírio dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-83ckh3	<NULL>	Patients undergoing cardiac surgery with cardiopulmonary bypass; age of 18-65 years.	Non-elective surgery; weigh less than 50 or more than 100 kg; history of psychiatric disorder; ASA physics status of class IV; patients with a mental impairment, knowledge about allergy to studied drugs;  patients with congenital cardiac disease and the patients that don&apos;t give informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-7sxygc	Effect of Physical Activity and blood glucose after meal in people with Diabetes	Recruitment completed	Intervention	2019-10-08	<NULL>	<NULL>	3048	Effect of Physical Activity on postprandial blood glucose in individuals with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Ceará	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7sxygc	<NULL>	Both sexes, age between 40 and 80 years, clinical diagnosis of diabetes mellitus type, pharmacological plan unchanged in the last eight weeks	Fasting glycemia greater than 250 mg / dl, insulin treatment, body mass index greater than 39.9 kg / m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-4fdmhm	Distúrbios mentais maternos na gestação e no pós-parto: detecção  e tratamento que refletem na relação familiar	Recruitment completed	Intervention	2019-10-08	<NULL>	<NULL>	3049	Maternal neuropsychiatric disorders in the pregnancy-puerperal cycle: detection and early intervention and its consequences in the family triad	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4fdmhm	<NULL>	Pregnant women with depression; Pregnant Women at Risk for Depression	High Suicide Risk; Substance dependence; Performing prior psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-2b4fyr	A long-term study with a multi-specialty approach to evaluate the acceptance of the accelerated recovery protocol in patients who were submited a  videolaparoscopic surgery for colorectal diseases	Recruitment completed	Intervention	2018-01-16	<NULL>	<NULL>	3050	A prospective study of the acceptance of the multimodal accelerated recovery protocol, Fast-Track,in patients submitted to videoolaparoscopic colorectal surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-15	Hospital Felicio Rocho	Hospital Felicio Rocho	https://ensaiosclinicos.gov.br/rg/RBR-2b4fyr	<NULL>	Patients older than 18 years of age, who had colorectal diseases and indicated elective surgical treatment by laparoscopy, with anastomosis, with or without ostomy	Patients submitted to conversion from laparoscopic surgery to open surgery, by laparotomy;Patients with colorectal cancer in the terminal stage;Patients with ASA III classification, or higher;Patients with mental disorders or psychiatric disorders;Patients with previous esophageal, gastroduodenal or pancreatic surgery;Patients with contraindication to laparoscopic surgery;Pregnant patients;Patients who refuse to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-7p6568	Oral hygiene in critically ill patients	Recruiting	Intervention	2019-10-08	<NULL>	<NULL>	3051	Oral hygiene in critically ill patients - a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7p6568	<NULL>	Patients admitted to the Intensive Care Unit of the Federal University of Uberlândia Hospital das Clínicas from 2019 to 2020; dependent on mechanical ventilation for more than 48 hours; regardless of gender; over 18 years old; head trauma victim	Patients under 18 years of age; undergoing endotracheal intubation 48 hours before admission; mechanical ventilation dependents before 48 hours; diagnosis of pneumonia prior to admission; burns; pregnant women; patient in palliative care; patients with restrictive measures; brain death at presentation; if the research participant is identified	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-587ptd	Health Product Irritability and Sensitization Assessment through Contact Test	Not yet recruiting	Observational	2019-10-08	<NULL>	<NULL>	3052	Assessment of Primary, Accumulated Dermal Irritability and Health Product Sensitivity by Patch Test _Mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-18	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-587ptd	<NULL>	"Healthy skin in the region of study (back); Age 18 to 65 years; Gender: male or female; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation / allergy to the material used in the study; o Have signed the Informed Consent Form (FICF);
Participants wishing to participate in the study without financial gain. They will be reimbursed for test-related expenses such as transportation and food."	"Participants who refuse to participate in the study in question.
Skin tags in the experimental area that interfere with the evaluation of possible skin reactions;
Active dermatoses (local and widespread) that may interfere with the study results;
Pregnant or lactating women;
History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines;
o Volunteers with a history of allergy to the material used in the study;
History of atopy;
History of conditions aggravated or triggered by ultraviolet radiation;
carriers of immunodeficiencies;
Kidney, heart or liver transplantation;
Intense sun exposure or tanning session up to 15 days prior to initial assessment;
Prediction of intense sun exposure or tanning session during the study period;
Prediction of bathing in the sea, pool or sauna during the study;
Participants who practice water sports;
Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection;
Treatment with acidic vitamin A and / or its derivatives orally or topically within 1 month before the start of the study;
Expected vaccination during the study or up to 03 weeks before the study;
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-88r347	The effect of music on the improvement of patients with breast cancer undergoing chemotherapy	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	3053	"Effect of musical stimulation on the reduction of adverse symptoms and hemodynamics
(blood pressure and heart rate) in patients with breast cancer in
chemotherapy treatment."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-88r347	<NULL>	Volunteers with breast cancer; women; between 16 and 75 years; in chemotherapy	Extremes of age; metastatic cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-4b7tyd	Physical activity intervention with motion sensors in adolescents	Not yet recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3054	Effect of a physical activity intervention - home based on cardiometabolic risk factors  in  adolescents	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-10	Gessika Castilho dos Santos	Antonio Stabelini Neto	https://ensaiosclinicos.gov.br/rg/RBR-4b7tyd	<NULL>	Be enrolled in basic education regularly; be between 13 and 18 years old; being overweight or obesity ( greater than 85th percentile); not be diagnosed with: cardiovascular disease, diabetes,  hypertension; not having been participating in a physical activity or exercise program for at least three months; do not have any kind of genetic, neoplastic or mental disease.	The adolescente will be excluded if: he/she doesn´t meet the pre-participation recommendations in the physical tests and did not participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-8s5v5f	Comparison between the effects of neuromuscular training and video game rehabilitation in the treatment of Parkinson&apos;s disease patients	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	3055	Comparison between the effects of fnp-based training and virtual rehabilitation in the treatment of Parkinson&apos;s disease patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-06	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-8s5v5f	<NULL>	Age between 40 and 80 years; to present PD in the 1 to 3 stage according to the modified Hoehn and Yahr classification; sign the Free and Informed Consent Form and the Authorization of Images and Testimonials.	Present cognitive alterations according to the Mini Mental State Examination, observing the following score: if illiterate: score below 19 points, with 1 to 3 years of schooling: score below 23 points, with 4 to 7 years of schooling : score lower than 24 points, and above 7 years of schooling: score lower than 28 points; have neurodegenerative diseases, excluding PD, and osteomioarticular diseases that prevent physical activity, uncontrolled chronic diseases (hypertension, diabetes mellitus, chronic pain), unstable cardiovascular diseases (acute heart failure, recent myocardial infarction, unstable angina and uncontrolled arrhythmias), in addition to being a user of alcohol and / or other toxic substances, contraindications to exercise according to the criteria of the American College of Sports Medicine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-8q58cj	Different application times of myofascial release on anterior thigh muscle strength	Recruitment completed	Intervention	2019-10-09	<NULL>	<NULL>	3056	Effect of different duration times of application of myofascial release on quadriceps femoris strength: A randomized experimental study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-14	Julio Guilherme Silva	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8q58cj	<NULL>	"Men between 18-35 years old; physically active; verified by the
international physical activity questionnaire (IPAQ)"	Lower limbs post-operative history in the last 12 months; unconsolidated fractures in the lower limbs; respiratory or cardiovascular diseases considered to be risky or limiting factor for the strength test; lower limb and/or lower back pain during the tests and difficulty performing the requested procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-6d7twh	Prospective, randomized study of chronic pain in the inguinal region and recurrence after inguinal hernia surgery by videolaparoscopy by intra-abdominal technique comparing mesh fixation with staples, glue or just its placement	Data analysis completed	Intervention	2019-10-09	<NULL>	<NULL>	3057	Prospective , randomize study of inguinodinia and recurrence after videolaparoscopic inguinal hernioplasty by transabdominal technique comparing mesh fixation with tackers , glue or no fixation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-6d7twh	<NULL>	patients of both genders; age between 18 and 75 years; body mass index (BMI) less than 35 kg / m2; unilateral inguinal hernia patients classified as Nyhus Type II or III; American Society of Anesthesiology Physical State Classification (American Society of Anesthesiology - ASA) I, II and III.	Patients with bilateral inguinal hernia; recurrence , encarcerated; strangled; ; Users of chronic painkillers; Corticosteroid users; patients with fibromyalgia; patients on antidepressants; anxiolytics, carbamazepine, diphenylhydantoin, gabapentin, and pregabalin; patients with previous surgery on the ínguino-crural region; right iliac fossa; hypogastrus; Patients with benign prostatic hyperplasia, not released after urological evaluation; Patients undergoing prostatic surgery for cancer or not; American Society of Anesthesiology (ASA) IV and V Physical State Classification and Users of Illicit Drugs and Alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-6pxpvx	Health of school children with food difficulties who receive supplementation for six months	Not yet recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3058	Clinical evolution of pre-school children with feeding difficulties supplemented during six months: a prospective controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de São Carlos	Clínica Nutre	https://ensaiosclinicos.gov.br/rg/RBR-6pxpvx	<NULL>	Age between 24 and 60 months. Presence of feeding difficulty characterized as at least one of the aspects mentioned below by parents or guardians to the professional who referred and validated in the initial assessment made by the nutritionist, namely: Inadequate amount of macro and / or micronutrient intake; Inadequate quality of food; Inadequate variety of food; Presence of one of the eating difficulty criteria elaborated by Kerzner et al and described in the IMFED system, namely: Misinterpretation of parents; Agitated child with little appetite; Emotionally compromised or neglected child; Presence of organic disease; Highly selective ingestion Food phobia.	Presence of cow&apos;s milk protein allergy; Presence of lactose intolerance; Impossibility of oral feeding; Presence of neoplasia, renal failure, liver failure; or heart disease under treatment; Presence of genetic syndrome; Presence of anorexia nervosa; Presence of chronic diarrhea or inflammatory bowel disease; Delayed growth and development related to chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-4mdb59	Clinical trial involving patients with indication of endoscopic drainage of Pancreatic Collections with the aim to compare rates of displacement of two type of prothesis: with and without anti-migration systems	Recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3059	Randomized clinical trial to evaluate the migration rate of fully covered self-expanding metal stent with anti-migration systems compared to fully covered self-expanding metal stent without anti-migration system in the Endoscopic Treatment of Fluid Pancreatic Collections	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Hospital das clínicas da Universidade de Sao Paulo	Hospital das clínicas da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mdb59	<NULL>	Patients of any age; any gender; with the diagnosis of fluid pancreatic collection with definite ethiology of acute pancreatitis identified by abdominal radiological study after 4 weeks of onset of acute event; with symptoms such as pain or compression of the intra-abdominal organs by the collection or infected collections or causing sepsis	"Patient who refuses to sign the informed consent;pancreatic fluid collection with less than 4 weeks after acute pancreatis;Cystic Formation less than 6 centimeters and without symptoms;
food residues in the stomach during endoscopic exam;collection distant from the pancreas that prohibit endoscopic drainage because because it has no contact with the stomach or duodenum; evidence of bleeding inside of the collection; septic shock defined as an abdominal sepsis that does not respond to intravenous fluid and requires cardiac inotropic support or vasopressors"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-3jhzz3	The effect of combined aerobic exercise with upper limb therapy on central nervous system growth factors and the manual dexterity of individuals after stroke	Recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3060	The effect of aerobic exercise associated with Modified Constraint Induced Movement Therapy in chronic hemiparetic subjects: Randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-10	Universidade Federal de São Carlos - UFSCar	Universidad del Rosario	https://ensaiosclinicos.gov.br/rg/RBR-3jhzz3	<NULL>	"Individuals with hemiparesis who present the last episode of stroke (ischemic or hemorrhagic) for more than 6 months (chronic phase after stroke). Individuals with more than one stroke may be included as long as the insult involves the same hemisphere. Only individuals who have strokes involving the territories of the middle and anterior cerebral arteries will be included. Individuals must submit a referral, imaging tests and medical report with the diagnosis of stroke. The age range should be between 35 and 80 years.
As a criterion for the implementation of the ICM protocol, all participants should present a minimum active movement of 45 ° of flexion and abduction of the shoulder, 20 ° of elbow extension, 10 ° of wrist extension, 10 ° of abduction or extension of the thumb , and 10 ° extension in at least two fingers (metacarpophalangeal and interphalangeal joints) beyond the thumb.
In addition, they should show asymmetry in the use of the upper limbs with a score of ? 2.5 in the Motor Activity Log quantity scale. For the proposed activities, individuals should be able to remain in the seated posture without trunk and arms support 1 minute."	"individuals with cognitive deficits according to the Mental State Mini Exam (score less than 13 for illiterate individuals, 18 for individuals with 1 to 7 years of study, and 26 for individuals with more than 8 years of study); individuals smokers, alcohol users, users of illicit drugs; individuals with structural abnormalities in cardiovascular systems such as hypertrophic cardiomyopathy, aortic aneurysm, left bundle branch block; and respiratory; individuals with uncorrected auditory and visual deficits; electrocardiogram (ECG) abnormalities such as ischemic changes, arrhythmias (atrial fibrillation, atrial flutter), conduction disorders, both at rest and during the clinical exercise test, to be lauded by a cardiologist. In addition, individuals with historical diseases or osteomioarticular alterations that prevent the performance of the procedures or generate pain during the activities, obese (BMI&gt; 28 kg / m2), with diabetes and uncontrolled hypertension, comprehension aphasia, apraxia, stroke bilateral, acute or subacute (&lt;6 months) stroke, transient vascular accident and other central and peripheral nervous system diseases and / or insult due to HIV. Also not included are individuals who are participating in other experimental or rehabilitation studies and who have had botulinum toxin application in the last three months prior to evaluation.

Individuals will have their participation interrupted in the study, if they present pain during the procedures, changes such as postural hypotension, angina, marked alteration of blood pressure (PAsystolic &lt;100 mmHg or&gt; 160 mmHg and PAdiastolic &lt;60 mmHg or&gt; 110 mmHg) or frequency (HR max = 220-age - men or 210-age women), as well as peripheral oxygenation &lt;90% or perception of dyspnea on the BORG&gt; 15 scale (0-20)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-6hnmxv	Assessment of skin irritability.	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3061	Dermatological assessment of primary dermal irritability accumulated and sensitization.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-08	Ipclin - Pesquisa Clínica Integrada	Vita vert industria e comercio de cosmeticos ltda	https://ensaiosclinicos.gov.br/rg/RBR-6hnmxv	<NULL>	Full skin in the study region (back); Age 18 to 65 years; Gender; male or female, Participants with phototypes I; II; III and IV (according to Fitzpatrick&apos;s classification); Absence of irritation  allergy history to the material used in the study; Have signed the Term of Free and Informed Consent (TCLE); Participants who want to participate in the study without financial gain. They will only be reimbursed for transportation and food expenses.	"Participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions (pigmentation disorders; vascular malformations; scarring; increased hairiness; ephelides and nevus in large quantities; sunburn); Dermatoses (local and disseminated) that could interfere with the results of the study; Pregnant women or infants; History of allergic reactions; irritation or intense discomfort feelings to topical products; for health and medicines; Volunteers with a history of allergy to the material used in the study; History of atopy; History of conditions aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Kidney; cardiac or hepatic transplanted patients; Intense sun exposure or tanning session up to 15 days prior to initial evaluation; Forecast of intense sun exposure or session of bron during the course of the study; Forecast of bathing; pool or sauna during the study; Participants practicing aquatic sports;
Use of the following topical systemic medicinal products; immunosuppressive; antihistaminic; non-hormonal anti-inflammatory drugs; and corticosteroids up to two weeks prior to selection; Treatment with acid vitamin A and  or its derivatives via oral or topical use up to 01 month before start of the study; Vaccination prediction during the study or up to 03 weeks before the study; Any condition not mentioned above that in the opinion of the investigator could compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-7jtmpc	"Mothers of newborn infants before the time or in the right time hospitalized in neonatal ICU, under the use of natural intervention based on flowers: 
clinical research where neither the researcher nor the participant nor the statistician knows which group they belong to and the groups are made by lot"	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3062	Mothers of premature and premature newborns hospitalized in a neonatal ICU, under intervention of Bach florals: clinical trial, triple blind, randomized	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-17	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jtmpc	<NULL>	Puerperas older or younger than 18 years old with free and informed consent, for adults and  or parents and guardians, and Term of Assent, for minors, with no age limit, single-gestation, whose premature born less than 37 weeks old, who are hospitalized at the Neonatal or Semi-Intensive Care Unit for at least 48 hours, who have visited the child at least once, do not present a contraindication to breastfeeding, and have started the expression of the milk in the first 24 hours of hospitalization, which exhibit some level of stress measured from the Parental Stress Scale: Neonatal Intensive Care Unit	Mothers of newborns who are breastfeeding directly in the mother, puerperal women using galactagogues and  or anxiolytics and antidepressants, with mammary malformation or reduction or mammoplasty; foreigners, due to the difficulty of communication and cultural difference, drug users, who do not have a mobile phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-57t7vb	Comparison of different training methods in diabetic health parameters	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3063	Acute and chronic comparison of different methods of training in kinanthrometric parameters, Cardiovascular, biochemical and metabolic disorders of diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-08	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-57t7vb	<NULL>	Will be included female and male volunteers over 10 years until 90 years and who do not have medical restriction to exercise or any kind of secondary diseases that may be aggravated due to research participation (secondary diseases already diagnosed by the doctor responsible for each diabetic (eg, peripheral and or central vasculopathies, retinopais and amputations).	Those who do not finish the sessions (acute), begin the practice of physical exercises during acute and chronic designs, or suffer any type of osteo-articular injury that prevents the practice of physical exercises or at the request of the doctor responsible for the exercise. each diabetic outside the scope of the research. In the chronic phase, volunteers who do not participate in at least 50% of the sessions will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-4rhbpq	"Phytochemical study and development of human supplementation based on
biochemical exams  with a standardized extract of watercress"	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3064	"Phytochemical study and development of human supplementation based on
biochemical parameters with a standardized extract of Nasturtium officinale R.Br.
Brassicaceae"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Universidade Federal do Pararna	Universidade Federal do Pararna	https://ensaiosclinicos.gov.br/rg/RBR-4rhbpq	<NULL>	Volunteers with a physical disability, such as spinal cord injury; cerebral palsy and amputated; aged between 18 and 65 years old;  para-sport practicer; being a member of Physical disability of Parana.	Volunteers using cholesterol, diabetes, antibiotics and anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-64gk7r	Clinical study to evaluate different adhesives in denture retention	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3065	Clinical, microbiological and patient-centered evaluation of different denture retention adhesives. Randomized crossover clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-26	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo.	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-64gk7r	<NULL>	Being clinically satisfactory users of total maxillary and mandibular prostheses (duration of prosthesis use is 1 year or less); properly understand both spoken and written Portuguese; be able to provide informed consent; being able to understand the study procedures and have the ability to perform them	"Presence of oral mucosal lesions such as denture-induced fibrous hyperplasia, papillomas or traumatic ulcerations associated with prosthesis bases or prosthesis-related stomatitis;
Impaired cognitive function;
Inability to attend returns for evaluation and maintenance;
Patients on medications such as antibiotics, antifungals, immunosuppressants, anticoagulants and corticosteroids during the last 3 months prior to the survey."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-9crqgt	Differences between two types of nutritional education programs	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3066	Internet - based nutrition education versus conventional nutrition education: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de Alagoas	Instituto Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-9crqgt	<NULL>	Age between 10 years and 19 years; students from Ifal Murici and Satuba campus; students from Monsenhor Clóvis Duarte de Barros State School, União dos Palmares	Inability to perform anthropometric measurements; special needs; pregnant or nursing; patients with acquired immunodeficiency syndrome; patients of type I diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-5xrnrm	Effect of orientation on stress and quality of life of elderly relatives with behavioral changes	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3067	Effect of an educational intervention on the emotional or psychological distress and quality of life of family caregivers of elderly with neuropsychiatric symptoms	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-18	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5xrnrm	<NULL>	Inclusion criteria for the elderly to be 60 years of age or older; male or female; with medical diagnosis of Alzheimer&apos;s disease or mixed dementia; classified as mild dementia or moderate dementia; in the outpatient clinic of geriatrics and dementias; presenting one or more neuropsychiatric symptoms and being cared for by a family member. inclusion criteria for the caregiver be the main family caregiver of the elderly selected for the research; reside with the elderly; male or female; aged 18 years or over; reside in the city of Ribeirão Preto; present emotional or psychological erosion and present a preserved cognitive state	Exclusion criteria for the elderly be institutionalized; classified as severe dementia.there is no exclusion criterion for the caregiver	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-3tk7fw	The effect of virtual reality on rehabilitation of elderly with balance disorder	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3068	Immersive virtual reality in the rehabilitation of elderly with postural balance alteration: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-13	Universidade Federal de Sergipe	Universidade Estadual de Ciências da Saúde de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3tk7fw	<NULL>	Male and female individuals; aged between 60 and 79 years old; with balance changes, previously diagnosed by a specialist doctor (otolaryngologist, neurologist or geriatrician).	Elderly unable to understand and respond to simple verbal commands; unable to remain independently in the standing position; in use of walking aids; with severe or uncompensated visual impairment with corrective lens use; with orthopedic disorders that result in limited movement; use of lower limb prostheses; have performed body balance rehabilitation in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-36dr7t	Effect of a toothpaste containing fluorine, calcium and phosphate for the treatment of tooth sensitivity.	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3069	Effect of a fluoride, calcium and phosphate dentifrice on the treatment of dentin hypersensitivity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Norte do Paraná - UNOPAR	Editora e Distribuidora Educacional S/A	https://ensaiosclinicos.gov.br/rg/RBR-36dr7t	<NULL>	Adult patients; age between 18 and 45 years; both genders; healthy; without systemic changes or continuous use of medications; having at least one tooth with an exposed root surface caused by abrasion, abrasion, erosion or gingival recession from which a painful response is elicited by a blast of air	PPatients with physiological changes; not classified as ASA I (pregnant women, patients with chronic diseases, patients with infectious foci in the oral cavity); teeth with evidence of pulpitis (tooth nerve pain), carious lesions, defective restorations, and active severe periodontal (gum) disease; use daily analgesic medication or any other medication that may mask painful symptoms; routinely use desensitizing toothpaste or any other desensitizing agent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-2kcbxz	Evaluation of the effectiveness of a single session of Solution Focused Brief Therapy to improve specialized treatment adherence in users of alcohol and other drugs	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3070	Evaluation of the effectiveness of a single session of Solution Focused Brief Therapy to improve specialized treatment adherence in users of alcohol and other drugs	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2019-05-29	Cristiana Nelise de Paula Araujo	Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2kcbxz	<NULL>	Individuals who seek the CAPSad user embracement.	Being unable to respond to the instruments at the time of the interviews, according to the researcher&apos;s evaluation; be less than 18 years of age; have been sent by court order.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-38kgxy	Effect of Neuroscience Education in Pain combined to Pilates in Catastrophization for Elderly with non-specific Chronic Low Back Pain: A Randomized Controlled Trial	Data analysis completed	Intervention	2019-01-03	<NULL>	<NULL>	3071	Pain Neuroscience Eucation for the older people with chronic low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-38kgxy	<NULL>	"Participants will be recruited from the municipality of São Carlos through advertisements in the community and media.
Individuals aged 60 years or older with non- specific chronic low back pain who score the minimum score according to schooling in the Mini Mental State Examination MMSE and do not present depressive symptoms in the Geriatric Depression Scale GDS-15.For the classification of chronic pain was used the criteria of the International Association for the Study of Pain IASP, which recommends that, for research, the chronicity of pain is defined as lasting more than six months (IASP, 2015)."	All older people that have undergone physical therapy for pain management within 6 months prior to the intervention, or undergone surgical treatment for CLBP were excluded, involvement in regular sports activities that have the same physical benefits as Pilates, such as improved muscle strength and stretching. Those with diagnosis of central sensitization syndromes (such as fibromyalgia), cancer and active inflammatory diseases, or with pain associated to previous spine or lower limbs fracture, and those that already regularly performed physical activities with therapeutic aims of stretching and strengthening similar to Pilates will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-8dv3kg	Effects of virtual reality based exercise on mental and physical health of elderly resident in long-term care facility	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3072	Effects of virtual reality based exercises on mental health, physical performance, muscular quality, inflammatory profile and cerebral activity of elderly resident in long-term care facility: double-blind, randomized, controled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal Fluminense	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-8dv3kg	<NULL>	To be elderly long-term care facility resident. To have preserved comunication capacity	Have a history of severe heart disease without medical release to perform physical exertion. To present acute musculoskeletal injuries that make it impossible to perform the exercises. To present severe sequelae of cerebrovascular accident or advanced neurodegenerative diseases. To present impossibility of applying the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-63pc4t	Relation of GREEN TEA with the prevention of CÂNCER OF THE LARGE INTESTNE AND RECTUM	Recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3073	Impact of Green Tea supplementation and it&apos;s relationship in the prevention of Colorretal Cancer in a western population	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-06-01	A.C.Camargo Cancer Center	Essentia Farmácia Homeopática	https://ensaiosclinicos.gov.br/rg/RBR-63pc4t	<NULL>	Patients older than 20 years with Lynch syndrome with a mutation identified or meeting Amsterdam criteria will be included in the study with colonic colonoscopy of the screening colonoscopy; participants who agree to participate in the research by signing the Free and Informed Consent Form.	Presence of inflammatory bowel disease (such as ulcerative colitis and Crohn&apos;s disease); history of organ transplantation or co-administration of immunosuppressive drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-26frc3	Evaluation of the benefit of different doses of dipyrone in third molar surgery	Recruitment completed	Intervention	2019-10-10	<NULL>	<NULL>	3074	Evaluation of the efficacy of different doses of dipyrone in third molar surgery: clinical trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-26frc3	<NULL>	Healthy patients aged between 18 and 35, thus patients who did not present systemic alterations nor used continuous medication. The lower third molars should have the same angulation (mesio-angular, rectangular, vertical or horizontal), similar root formation, and the same degree of impact as Pell and Gregory classification. The teeth should be impacted. The patient should also not have pericoronitis within the last 30 days before surgery, and the region could not have signs of inflammation.	Patients who did not agree to participate in the study after reading the consent form; had an allergy to the medicines used; did not fit the planning of surgical and anesthetic techniques; had a history of haematological disease or gastrointestinal bleeding; pregnant and lactating women; smokers; did not return to the second surgery (surgery on the opposite side); used other medications in the postoperative period; postoperative infection; difference greater than 10 minutes between the surgical times of the operated sides.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5syh8r	Restorations of cavities near carious gingiva with single increment resin	Recruitment completed	Intervention	2019-10-11	<NULL>	<NULL>	3075	Restoration of caries-free cervical lesions with composite bulk fill resin - clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Universidade Estaudual do Oeste do Paraná	Universidade Estaudual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5syh8r	<NULL>	"Adults 18 to 60 years of age;
Lesions close to the gingival tissue present in structurally compromised posterior teeth (class V);
Absence of periodontal disease;
The teeth must have occlusal contact with the antagonist;
Possessing occlusal balance and absence of premature contacts."	"Possessing active periodontal disease;
To have dental mobility in grades I, II and III;
Possess uncontrolled caries activity;
Xerostomia;
Being in orthodontic treatment;
Bearing mandibular temporal dysfunction;
History of systemic diseases with repercussion in the gingiva and periodontal tissues;
Adverse reaction history to any of the materials used in this study;
To have a parafunctional habit;
Use of myorelaxant apparatus;
Pregnancy or lactation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2cxg63	Soothing effect of natural medicines prior to extraction of the wisdom tooth.	Recruitment completed	Intervention	2019-10-11	<NULL>	<NULL>	3076	Sedative effect of the association between Valeriana officinalis L and Humulus lupulus L. on anxiety control in patients submitted to mandibular mandibular third molar extractions.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2cxg63	<NULL>	Healthy volunteers ASA I; age between 18 and 30 years; presence of bilateral mandibular third molars included, asymptomatic and in similar positions and surgical difficulties based on the internationally accepted scientific classification of Pell and Gregory, verified by current panoramic radiography.	Patients ASAIII or IV; history of use of any type of anxiolytic drug in the 15 days prior to the beginning of the research; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation; previous history of pericoronaritis; extremely anxious or odontophobic patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-7w84sz	Analysis of lumbar spine movement with mobilization and with digit pressure	Recruiting	Intervention	2019-10-11	<NULL>	<NULL>	3077	Analysis of lumbar spine movement mobilization versus pressure movement mobilization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7w84sz	<NULL>	Healthy male volunteers aged 18 to 30 years.	Women; male under 18 and over 30 years old; medical diagnosis of neurological diseases; orthopedic; traumatological; rheumatologic diseases that promote changes in static balance or cause chronic pain; uncontrolled arterial hypertension and cutaneous lesions in the lumbar spine / lower limbs that might prevent data collection and / or interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5rzmzf	Care plan for carers of people with dependency	Not yet recruiting	Intervention	2019-10-11	<NULL>	<NULL>	3078	Instrumentation of informal caregivers of care-dependent patients during hospital-to-home transition	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-5rzmzf	<NULL>	"Care dependent person: age between 18 and 59 years; be the first episode of hospitalization for disabling illness; in the emergency care sectors; medical clinic or post-surgery sector of the University Hospital and Municipal Hospital; minimal upward forecast; have a Barthel index of 10 to 30 evaluated at the time of research recruitment;
 
Informal caregiver: 18 years of age and over and less than 80 years old; be primary informal caregiver; reside in the municipality; be literate; able to read and write; no intention to move the municipality during the research period; and be classified in the Mini Mental State Examination with scores between 22 24 and 26 according to educational level"	"Care dependent person: be transferred to a hospital or care institution other than home; need specialized health care;

Informal Caregiver: do not speak Portuguese"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2bn2z4	Effects of two physiotherapeutic interventions in women with loss of urine following stroke	Recruiting	Intervention	2018-12-11	<NULL>	<NULL>	3079	Effects of tibial and parasacral nerve stimulation techniques in women with hyperactive neurogenic bladder after stroke.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-06	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2bn2z4	<NULL>	The inclusion criteria of the patients in this research are: age between 40 and 70 years; carriers of ischemic or hemorrhagic stroke; who has more than one month post AVC with overactive bladder; without infection in the urinary tract and bladder tumor, without cognitive deficit (mini-mental&gt; 18).	The criteria for excluding patients in this research are pregnant women, women who already had urinary incontinence before the stroke episode, women who have pacemaker implantation and taking neurogenic bladder medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-4n2c59	Absorption of Amoxicillin tablets in overweight volunteers	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3080	Determination of pharmacokinetic profile of Amoxicillin tablets in overweight volunteers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-16	Hospital Universitário Regional de Maringá	Hospital Universitário Regional de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-4n2c59	<NULL>	Volunteers with obesity according to the classification proposed by the World Health Organization (BMI 30 to 40 kg / m²); being between 18 and 50 years old; have signed the consent form.	Intolerance or hypersensitivity to Amoxicillin and other antibiotics of the class; kidney or liver failure; pregnancy; breast-feeding; users of alcohol or illicit drugs; use of prokinetics (metoclopramide, erythromycin or domperidone); participation in clinical study in the last 3 months; have thrombocytopenia, anemia, heart disease, diabetes and / or hypertension, and endocrine disorders; being under 18 years old and over 50 years old; volunteers with difficulty in swallowing and / or presenting fistulas, significant stenosis or obstruction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-6wjnjh	Auditory function assessment in elderly with hearing loss before and after hearing rehabilitation	Recruiting	Intervention	2019-10-14	<NULL>	<NULL>	3081	Auditory function assessment in elderly with presbycusis before and after hearing rehabilitation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	UNESP Universidade Estadual Paulista Julio de Mesquita Filho, Campus de Marília	UNESP Universidade Estadual Paulista Julio de Mesquita Filho, Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-6wjnjh	<NULL>	Age group of 60 years or more; both genres; presence of hearing loss / presbycusis; indication of an otorhinolaryngologist to adapt hearing aids	Presence of alteration of the middle ear and / or hearing loss in the frequencies of 0.50, 1 and 2 kHz and / or thresholds 71 dBNA in the frequencies of 3 to 8 kHz, detected by impedanciometry and pure tone audiometry; positive tracing of cognitive impairment detected by the MoCA - Montreal Cognitive Assessment, in its Portuguese version.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-7h9mmy	Education on evidence-based health for journalism students	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3082	"Medical journalism: evidence-based healthcare teaching for journalism students
as a tool to improve the quality of information"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7h9mmy	<NULL>	"3rd and 4th year undergraduate students in journalism or recent graduates in journalism in 2016 at Faculdade Cásper Líbero.
Spontaneously and voluntarily agreeing to participate in the educational intervention."	Do not agreeing to participate (as a volunteer)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5kk5j2	Implementation of a quality improvement program for cardiac enzymes ordering in critically ill patients	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3083	Implementation of a quality improvement program for cardiac enzymes ordering in critically ill patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto Sírio-Libanês de Ensino e Pesquisa	Instituto Sírio-Libanês de Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-5kk5j2	<NULL>	Patients admitted to one of the study units and the intensivist request for serum cardiac enzymes measurement; older than 18 years old.	Unit stay less than 12 hours; pregnancy; life expectancy less than 48 hours; end-of-life care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-683qhf	Use of high concentration whitening gel to reduce dental sensitivity after tooth whitening	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3084	Use of high concentration Carbamide Peroxide to minimize Postoperative Sensitivity and obtain good Bleaching Results	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-10	UEPG - Universidade Estadual de Ponta Grossa	CESCAGE - Centro de Ensino Superior dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-683qhf	<NULL>	Healthy volunteers; Both genders; Age between 18 and 40 years, with upper and lower anterior teeth with vitality; Adequate oral hygiene; With central incisors that should be A2 or darker in color according to the Vita scale (VITA classical, VITA Zahnfabrik, Bad Säckingen, Germany)	Voluntary smokers; Pregnant and lactating women; Patients with teeth showing staining caused by tetracycline; Fluorosis; Hyperplasia; endodontic treatment; Presence of restorations in the eight upper and lower anterior teeth; Previous dental sensitivity; Parafunctional habits; Cervical lesions (abrasion, erosion and abfraction), periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-8bt38c	Allergic inflammatory cytokine analysis and concentration of nickel ions in patients with orthodontic appliance	Recruitment completed	Intervention	2019-10-14	<NULL>	<NULL>	3085	Analysis of type IV hypersensitivity cytokines and their correlation with the concentration of nickel ions in saliva and urine of patients under orthodontic treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-25	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8bt38c	<NULL>	Healthy volunteers; both genders; non smokers; Minimum age of 12 years, with Class I malocclusion, Angle; No previous orthodontic treatment; Without missing teeth; Without extensive metal restorations; No systemic diseases.	Patients who do not sign the free and informed consent; Patients on immunosuppressive drugs; Patients using drugs that involve hypersensitivity as antibiotics or ati-inflationary.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5kbzdh	Dietary supplementation with Omega in pregnant and the placentary vascular resistance assessed through the doppler of the uterine arteries	Not yet recruiting	Intervention	2018-06-19	<NULL>	<NULL>	3086	Dietary supplementation of Omega 3 and the participation in the placentary vascular resistance mechanism in pregnant people: a comparison with normal pregnant women without use of Omega, chronic hypertensions in use of AAS and  pregnants with thrombophilia and use Heparina or  AAS	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina de Barbacena	Faculdade de Medicina de Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-5kbzdh	<NULL>	"Pregnant women enrolled in prenatal care of the institution.
Pregnant women who signed the free and informed consent form.
Pregnant women who attend the appointments (with even a missed prenatal) and agree to perform the protocol of the service, clinical examinations and imaging.
Pregnant women with hereditary or acquired thrombophilias identified
previously.
Pregnant women with identified risk factor for preeclampsia or CIUR selected from ACOG and NICE data adapted for this study:
i. Identification of two anamnesis clinical data (clinical history of PE in previous pregnancy, history
PE in first-degree relative, BMI&gt; 35 kg / m2, hypertension, nephropathy, disease
autoimmune).
ii. Identification of anamnesis clinical data associated with changes in uterine artery doppler in the
first trimester (IR, PI or bilateral doppler notch).
iii. MAP identification&gt; 100 in the first trimester of pregnancy associated with clinical history or Doppler
altered uterine artery (PI, IR, uterine artery notch)."	"Pregnant women - under 19 years.
Pregnant women who are absent from consultations - two or more consecutive prenatal absences.
Pregnant women who do not accept to use the omega in the prenatal or have intolerance to the use of the omega.
Smoking patients.
Gestantes without risk factor or thrombophilia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-467t4b	Osteopathic manipulation in adults with chronic gastritis and its influence on posture and movements of the stomach	Recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3087	Stomach mobility and motility, trunk posture and osteopathic manipulation in adults with chronic gastritis	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-18	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-467t4b	<NULL>	Chronic gastritis group: Adults between 18 and 59 years of age will be considered; of both sexes; endoscopic examination, accepted up to two years after its completion, of the presence of chronic gastritis.	Exclusion criteria for the two groups: another gastrointestinal alteration; pregnant women; pre-existing rheumatologic diseases, except osteoarthritis; relevant decompensated comorbidities (cancer, diabetes, thyroid disorders); hypotension and limiting respiratory diseases; arterial or venous insufficiency; renal or hepatic heart disease; presence of chronic postural deformities (scoliosis, kyphoscoliosis and true difference between limbs); thoracic / abdominal surgeries; neurological dysfunctions; changes in cutaneous integrity in the abdominal thoraco region, vestibular alteration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2pxsw7	Physiotherapeutic performance in the treatment of Mastalgia in women of the Center for Care of Women and Children (CASMUC)	Data analysis completed	Intervention	2019-10-15	<NULL>	<NULL>	3088	Physiotherapeutic performance in the treatment of Mastalgia in women of the Center for Care of Women and Children (CASMUC)	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2pxsw7	<NULL>	Patient diagnosed with Mastalgia not related to breast cancer, referred to CASMUC&apos;s medical outpatient clinic, above 18 years of age, and who accepted to participate in the study after reading and signing the Informed Consent Term (TCLE).	Women with uncontrolled systemic arterial hypertension and cognitive dysfunction were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5gdwzz	Comparison between sternal closure with sternal plate fixation versus steel wire after transverse sternotomy for bilateral pulmonary transplantation	Recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3089	Comparative study between esternal closure with sternal plate fixation versus steel wire in patients submitted to previous bilateral transverse thoracosternotomy (clamshell incision) for bilateral pulmonary transplantation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-29	Incor (Instituto do Coração)/ FMUSP (Faculdade de Medicina da Universidade de São Paulo)	Incor (Instituto do Coração)/ FMUSP (Faculdade de Medicina da Universidade de São Paulo)	https://ensaiosclinicos.gov.br/rg/RBR-5gdwzz	<NULL>	Above 18 years old; Belonging to the InCor transplant queue; Eligible for sequential bilateral lung transplantation submitted to clamshell incision.	Patients undergoing a new surgical procedure after lung transplantation requiring manipulation of the steel wires or sternal fixation plate other than for osteomyelitis; Intraoperative death; Patients who underwent unilateral lung transplantation or who did not undergo clamshell incision.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-5d26k2	Effectiveness of Behavioral Interventions aimed at Self-Care in Diabetes Mellitus	Recruitment completed	Intervention	2019-10-15	<NULL>	<NULL>	3090	Evaluation of the Effectiveness of Behavioral Interventions aimed at Self-Care in Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-05	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5d26k2	<NULL>	Degree of education above the fourth grade of elementary school and the possibility of attending bimonthly three times the educational practices.	patients with diabetes with reading disability; chronic complications (defined as renal failure; blindness; limb amputation; among others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-3c8wwt	Effects of Manual Osteopathy Treatment on the Signs and Symptoms of Lumbar Pain Volunteers	Recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3091	Effects of Osteopathic Manipulative Treatment on the Signs and Symptoms of Low Back Pain volunteers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-18	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3c8wwt	<NULL>	Present disability due to low back pain; classified by the Oswestry questionnaire; be between 18 and 50 years old	Presence of tumors of any kind; Being on medical treatment for low back pain or other symptoms and for depression; Having undergone any surgical procedure on the lumbar spine; Carriers of systemic, neurological, rheumatological diseases; Pregnancy; Being on physical therapy treatment; osteopathic pain in the last 3 months; have had amputation of the first phalanx of the fingers; have a pacemaker; have had myocardial infarction; have eaten or smoked in the last 2 hours prior to collection; have consumed alcohol in the last 24 hours prior to collection; Being on hormones and antidepressants; If the volunteer is using these drugs, the pharmacokinetics of the drug will be analyzed in the scientific literature, to verify if the time of effect of the drug ceased when the bioelectrographic collection; If the volunteer is still on the medication, her data will not be used in the analysis of the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-2kt4fj	The use of health applications and its relationship with the eating practices of adults and elderly individuals from Passo Fundo (RS)	Not yet recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3092	Influence of the use of health applications on eating practices of adults and elderly individuals from Passo Fundo (RS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Luísa Victória Biasi	Universidade de Passo Fundo (UPF)	https://ensaiosclinicos.gov.br/rg/RBR-2kt4fj	<NULL>	Have a smartphone with Android OS version 4.3 or higher; affinity with the use of applications; have internet at home and / or mobile	Pregnant women; elderly aged 80 years or older; people in need of special diets	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-6rkz85	Effect of sleep duration on performance-deficient, visually impaired athletes, physical performance, and hormones related to sleep, melatonin, and cortisol	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	3093	Effect of sleep duration on high performance poor visually impaired athletes, on physical performance and hormonal responses	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Capes	Fundo de apoio ao ensino, à pesquisa e extensão - Faepex	https://ensaiosclinicos.gov.br/rg/RBR-6rkz85	<NULL>	"For the data collection will be selected 12 Brazilian high performance athletes,
(B1, B2, B3), who participate in national competitions
Box and Brazilian Championships) and international of the modality swimming.
Regardless of age and gender."	"Athletes who make continuous use of
control sleep and depression. Also excluded are those that are in the depression."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-5s4yqh	Study of the application of protocol in the prevention of peri-intraventricular haemorragia in preterm newborns	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3094	Study of the Application of a bundle in the prevention of peri-intraventricular haemorragia in preterm newborns	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Estadual do Ceará	Maternidade Escola Assis Chateubriant	https://ensaiosclinicos.gov.br/rg/RBR-5s4yqh	<NULL>	To be premature with gestational age less than or equal to thirty-four (34) weeks at birth and / or Birth weight less than or equal to 1,500 (one thousand, five hundred) grams.	Newborns with congenital malformations, genetic syndromes and those with congenital infections of the TORCHS group (syphilis, rubella, herpes, toxoplasmosis and cytomegalovirus).  Newborns who died before the first ultrasonographic examination or were transferred to another institution due to overcrowding of the Neonatal Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-4dvhts	Transamin&apos;s benefit in decreasing blood loss in knee prosthesis patients	Recruitment completed	Intervention	2019-10-16	<NULL>	<NULL>	3095	Efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-21	Fundacao Hospital Adriano Jorge	Fundacao Hospital Adriano Jorge	https://ensaiosclinicos.gov.br/rg/RBR-4dvhts	<NULL>	Patients were regularly enrolled in the institution where the study was performed with a classic indication of TKA, recommended by Camanho: medial or lateral clamping with obliteration of the joint space, deviations in femoro-tibial varus greater than 15º; deviations in femoro-tibial valgus greater than 10º; femorotibial subluxation in the frontal plane greater than 10 mm; anteriorization of the tibia in relation to the femur in the profile radiography; severe involvement of two of the three knee joint compartments (femorotibial medial, femorotibial lateral or femoropatellar), and failure of conservative treatment for at least three months, when these criteria were not fulfilled. Patients with primary degenerative knee OA; for this evaluation, the patients with stage of knee arthrosis  III were considered, according to Ählback, modified by Keys	Patients who underwent knee prosthesis revision surgery, who did not use medial articular access, patients not operated by the senior surgeon, patients with rheumatoid arthritis, multiple scars, and those who refused to sign or did not understand were excluded from the study. TCLE. Any patient with decompensated diabetes mellitus (fasting glycemia&gt; 140 mg / dL), uncontrolled systemic hypertension (SBP &gt; 200 mmHg), peripheral vascular disease, previous thromboembolic events, acute myocardial infarction, neoplasia, active infection, rheumatoid arthritis, obese with (American Society of Anesthesiologists - ASA score&gt; III) and use of anticoagulants had their clinical condition reassessed and surgical procedure postponed. Patients who declared themselves indigenous	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-9rzr3r	Effects of hypertonic saline and Dornase alfa in children with cystic fibrosis	Recruitment completed	Intervention	2019-10-16	<NULL>	<NULL>	3096	Immediate effects of hypertonic saline and Dornase alfa on respiratory mechanics in children with cystic fibrosis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Renata Maba Gonçalves	UDESC	https://ensaiosclinicos.gov.br/rg/RBR-9rzr3r	<NULL>	This study included children and adolescents with CF between 6 to 14 years of age, under regular follow-up at the CF outpatient clinic in the Joana de Gusmão Children&apos;s Hospital (HIJG) in Florianópolis/SC-Brazil. The diagnosis was confirmed by two altered sweat tests (chlorine greater than 60mEqs/l) and confirmed genetic alterations. All participants were clinically stable at the time of data collection, according to the application of specific clinical scores. To assure clinical stability and inclusion of the participants, the Cystic Fibrosis Clinical Score (CFCS) [18] and the Cystic Fibrosis Foundation Score (CFFS) [19] for pulmonary exacerbation were applied.	Individuals who exhibited infection or upper airway alterations (coryza, sneezing, obstruction of nose, rhinitis and epistaxis) and who were unable to perform any of the study procedures were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-2c3kyz	Vacuum dressing for suture healing in pilonidal cyst surgery	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3097	Use of negative wound pressure device in surgical treatment of Pilonidal Cyst in closed technique.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-19	universidade de santo amaro	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-2c3kyz	<NULL>	Patients with primary or recurrent Pilonidal Cyst	Patients using anti-coagulants or decompensated systemic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-3w2scz	Effectiveness of minfulness in comparison to    non-drug standart therapy in smoking cessation	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	3098	Effectiveness of minfulness in comparison to   cognitive behavioral therapy in smoking cessation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w2scz	<NULL>	"Active smokers; over 17 years old; living in Curitiba, Brazil; with a current consumption equal or superior to 10 cigarettes a day; that haven´t achieved smoking abstinence for more than three months in the last year; who express a desire to quit smoking and consent to participate in the
study by signing the informed consent form (ICF)."	"The following will be excluded from the study: Alcoholics; drug addicts; patients taking medications for smoking cessation including
buproprion, nicotine in any form of administration and vanericline. Illiterate will also be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-5zm8cw	Use of photodynamic therapy in keloids	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	3099	Use of photodynamic therapy with methyl-aminolevulinic acid preventing recurrence and improving quality of live in patients with keloid scars: a protocol for a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-5zm8cw	<NULL>	This study will be conducted in men and women over 18 years with keloid.	"Who are pregnant or lactating. Who has received any medical treatment for the keloids in the last 6 months. Who has active neoplasms
Who has epilepsy. Who has diabetes. Who uses corticosteroids chronically. Who has history of allergy or hypersensitivity to the drugs (m-ALA and/or Lidocaine). Lesion dimensions that requires more complexity on the excision (like general anesthesia, reconstruction procedures) than ambulatorial surgery. Lesions larger than 10 cm². Who do not tolerate procedures with local anesthesia. Who cannot understand the study or do not sign the consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-8b27t9	Pharmaceutical Care for patients with Diabetes using Insulin	Recruitment completed	Intervention	2019-10-16	<NULL>	<NULL>	3100	Pharmaceutical Care for patients with Diabetes mellitus treated with Insulin	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8b27t9	<NULL>	Patients with diabetes mellitus treated with conventional insulin, attended by the Pharmacy of the Family Health Center of Fernandes Pinheiro; with cognitive ability; who agree to participate in the research by signing the Informed Consent Form.	Patients with cognitive difficulties who do not have a companion or caregiver, hindering the understanding of the pharmaceutical and study guidelines. Diabetes mellitus patients receiving insulin analogues or not receiving insulin treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-7y8rtz	Laser therapy effectiveness on skin with chemotherapy Side Effects, randomized clinical trial	Recruitment completed	Intervention	2019-10-16	<NULL>	<NULL>	3101	Intervention on the systemic adverse effects of modified intravascular laser irradiation of blood chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Unesp- Universidade Estadual Paulista	Unesp- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7y8rtz	<NULL>	Patients aged 18 years or older; in exclusive outpatient treatment; no self-reported cognitive impairment by patient and companion; with solid tumors; submitted to at least one chemotherapy cycle before data collection	Excluded patients will be those undergoing oral and / or subcutaneous and / or intramuscular chemotherapy only; those who do not have cognitive conditions to answer the form; as well as colostomized individuals; those taking medications known to affect the immune system; in hematological treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-567trz	Evaluation of the effect of a 6% potassium nitrate gel on tooth sensitivity during and after office whitening in adult patients	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3102	Effectiveness of a 6% potassium nitrate gel on sensitivity during and after office bleaching in adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-567trz	<NULL>	Patients of both sexes were included in the present study; aged between 18 and 40 years; who had at least six upper anterior teeth free of caries and restorations on the buccal surface; central or canine incisor with A2 or darker coloration; satisfactory oral hygiene; absence of periodontal disease.	The individuals excluded from the study were users of fixed orthodontic appliances; pregnant women; lactating women; severe intrinsic stains on teeth (stains due to tetracycline, fluorosis and pulped teeth); who were consuming any anti-inflammatory and antioxidant drugs; using desensitizing toothpaste; participants with a previous history of tooth sensitivity or any associated pathology (bruxism, gingival recession, noncarious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-6yrddt	Effects of sports and functional training in quality of life of adults with visual impairment	Recruitment completed	Intervention	2019-10-17	<NULL>	<NULL>	3103	Effect of sport exercises and functional training in levels of physical activity, physical fitness, pleasure and quality of life of adults with visual impairment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Escola Superior de Educação Física da Universidade Federal de Pelotas	Escola Superior de Educação Física da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6yrddt	<NULL>	The inclusion criteria for the study were to be in the age group of 18 years to 59 years and to have visual impairment (vision worse than 20/60) clinically proven.	People with other associated impairments (physical, hearing or intellectual) were not eligible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-2dc8kz	Effects of the selective strengthening technique for the internal musculature of the foot in type II diabetic volunteers. Randomized and controlled study	Not yet recruiting	Intervention	2019-10-17	<NULL>	<NULL>	3104	Effects of the selective strengthening technique for intrinsic skin musculature in diabetic volunteers of type II. Randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2dc8kz	<NULL>	Type II diabetes mellitus, according to American Diabetes Association criteria; between 20 and 70 years old; of both sexes; in diet therapy or with oral antidiabetic drugs  and signing the term of free and informed consent.	Individuals with type II DM with very high risk, ie those with previous ulcers and / or amputations, clinical diagnosis of hemiplegia, paraplegia, or Parkinson&apos;s disease; limb amputation; a history of alcohol or drugs; a herniated disc; leprosy; severe arthritis that prevents walking; insanity; intellectual disability; and other psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-9jgsb5	Using Behavioral Nutrition techniques for health promotion	Data analysis completed	Intervention	2019-10-17	<NULL>	<NULL>	3105	Using Health and Wellness Coaching techniques to change parameters of health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Escola de Educação Física e Esportes da Universidade de São Paulo	Escola de Educação Física e Esportes da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jgsb5	<NULL>	Women; overweight; premenopause	Men; women who are normal weight or obese; menopausal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-9fv3f4	Evaluation of the use of Pioglitazone combined with conventional Antifungals for treatment of meningitis caused by the fungus Cryptococcus	Not yet recruiting	Intervention	2019-10-17	<NULL>	<NULL>	3106	Randomized double-blind Pioglitazone repositioning trial combined with Antifungals for treatment of Cryptococcal Meningitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9fv3f4	<NULL>	Older than 18 years. Cryptococcal meningitis.	Under 18 years. Pregnancy. Diabettes mellitus. Active liver failure. Bladder tumor. Recurrence of cryptococcosis. Prior antifungal therapy. Hypoglycemia. Congestive heart failure. Hypersensitivity to pioglitazone. Sertraline. Amiodarone Atorvastatin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-5xwt6t	Spinal anesthesia for elective cesarean section. Use of local anesthetic at different doses of Fentanyl. Randomized Clinical Trial	Recruitment completed	Intervention	2019-10-18	<NULL>	<NULL>	3107	Spinal anesthesia for elective cesarean section. Use of the Bupivacaine Association at Different doses of Fentanyl. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Centro de Atenção Integral à Saúde da Mulher - Universidade Estadual de Campinas	Centro de Atenção Integral à Saúde da Mulher - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5xwt6t	<NULL>	ASA II or III; pregnant women; elective cesarean; age range from 18 to 65 years.	Chronic Fetal distress; acute fetal distress; body mass index higher than 40	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-8np98x	Realistic simulation with same profession students and with different profession students for teamwork competencies development: randomized clinical trial.	Recruiting	Intervention	2019-10-18	<NULL>	<NULL>	3108	Uniprofessional and interprofessional high fidelity simulation for the development of collaborative competencies: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-12	Alexandra Martins	UNIEURO - Centro Universitário Euro-Americano	https://ensaiosclinicos.gov.br/rg/RBR-8np98x	<NULL>	Healht science students (nursing, physiotherapy, nutrition and pharmacy); duly enrolled from the 5th semester onwards; enrolled for realistic simulation activity.	Students with any communication impairment; who do not sign the Informed Consent Form; who do not respond to the assessment tool.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-5h2yvf	Effect of maternal colostrum administration on oral mucosa of preterm infants on rates of late neonatal infection	Recruiting	Intervention	2018-09-27	<NULL>	<NULL>	3109	Impact of colostrum administration on the oral mucosa of preterm and very low weight on the sepsis rate: Randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-05	Universidade de Caxias do Sul	Hospital Geral de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h2yvf	<NULL>	Newborns with gestational age equal to or less than 30 weeks and / or weighing 1,500 g or less; signing of the Informed Consent Form (TCLE) by the parents or guardians of the concept.	Newborns without child support during hospitalization; RN carriers of complex congenital malformations; neonatal problems that contraindicate colostrum; HIV positive mothers; mothers who use drugs and / or substance abuse that contraindicate the supply of breast milk; use of vasopressor drugs; RN from twin pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2592hd	Fluid replacement in patients undergoing neurosurgery	Recruiting	Intervention	2019-10-20	<NULL>	<NULL>	3110	Evaluation of Plasma-Lyte and 0.9% Sodium Chloride Administration in Hydroelectrolytic Balance, Acid-Base, and Renal Function in Neurosurgery: Randomized Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-03	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2592hd	<NULL>	Patients undergoing neurosurgery, tumor resection, or aneurysm clamping and who are 18 years of age and older and classified as physical status ASA I, II, and III, according to the American Society of Anesthesiologists classification.	Patients or legal representative who do not accept to participate in the study, with refusal to sign the consent form; patients under 18 years old; any other neurosurgical procedure other than tumor resection or aneurysm clipping (head trauma, ventriculo-peritoneal shunt, etc.), patients with chronic kidney injury, pre-existing abnormality of acid-base and electrolyte disorder, pregnant women and patients in use of previous diuretics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2rnbw6	Relationship between oxytocin and borderline personality disorder	Not yet recruiting	Intervention	2019-10-20	<NULL>	<NULL>	3111	Association assessment between oxytocin and borderline personality disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2rnbw6	<NULL>	"women over 18 years of age; literate; of childbearing age; in contraceptive use for more than six months; who agree to participate by signing the Free and Informed Consent Form approved by the Ethics and Research Committee of the HCFMRP; who agree to measure levels of estrogen and progesterone to delineate the menstrual cycle; that are in the follicular phase of the cycle. For inclusion in the TPB group, women should have: a diagnosis of BPD performed using the criteria established by the DSM-5 classification; being in outpatient treatment.
In the control group, only women with no history of current or previous psychiatric disorder evaluated by SCID-5 will be admitted. In the study of continuous use, they will be admitted to women with BPD of childbearing age, over 18 years of age, without pretense of becoming pregnant within the next 6 months, who are literate and who agree to participate and sign the ICF approved by the HCFMRP Ethics and Research Committee. In addition, in this group, only women with a diagnosis of BPD will be accepted, based on the criteria established by the classification of DSM-5 (APA, 2014), in outpatient treatment; who agree not to modify their treatments during the study period."	Participants will be excluded from the study if they refer to clinical diseases that have a major impact on the functioning of the organism, such as degenerative diseases, neurological diseases, cancers, hematological, pulmonary, renal, hepatic and cardiovascular diseases; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2ccsnr	Evaluation of respiratory muscle strength before and after liver surgery and postoperative respiratory muscle training	Recruiting	Intervention	2019-10-21	<NULL>	<NULL>	3112	Preoperative assessment of respiratory muscle strength in open hepatectomy and postoperative inspiratory muscle training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Ciências Médicas	Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-2ccsnr	<NULL>	Individuals who underwent open hepatectomy of either sex of any race; ethnicity; sexual orientation; gender identity; class or social group; agreeing and signing the Informed Consent Form.	Laparoscopic hepatectomy surgery; hemodynamic instability; active bleeding; did not remove the artificial respiratory prosthesis in the first postoperative period; do not sign the free and informed consent form; non-collaboration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7pckqt	Postoperative pain measurement after knee anterior cruciate ligament reconstruction surgery with analgesic medications within the joint	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	3113	Evaluation of postoperative pain in patients undergoing arthroscopic knee anterior cruciate ligament reconstruction with intraarticular analgesic solutions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Fundacao Hospital Adriano Jorge	Fundacao Hospital Adriano Jorge	https://ensaiosclinicos.gov.br/rg/RBR-7pckqt	<NULL>	The following inclusion criteria were adopted: diagnosis of chronic knee instability; older than 18 years; classification of physical status according to the American Society of Anesthesiologists (ASA) I and II scale; no local and systemic inflammatory diseases; isolated injuries of the anterior cruciate ligament (ACL only), with no history of fractures or previous knee surgery; use as a graft the medial flexor tendons; operated by the principal researcher and his team	Exclusion criteria were: skeletally immature patients; chondral lesions larger than 2 cm2; associated surgical procedures such as osteotomies, and other ligaments; patients without clinical conditions, hypertensive, with coagulopathies, pregnant; chronic use of anticoagulants; analgesic use up to 24 h before the surgical procedure; patients who refused to sign the consent form; patients not operated at the institution: the anesthesiologist&apos;s refusal to follow the project protocol and patients who declared themselves indigenous; older than 65 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7y35v6	Effects of the combination of strengthening exercises and blood flow block on hand strength gain	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	3114	Comparison of different strengthening protocols associated with blood flow restriction to increase handgrip strength	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Universidade Federal de Santa Catarina- UFSC	Universidade Federal de Santa Catarina- UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7y35v6	<NULL>	Female volunteers; aged between 18 and 25 years old; students; and able to perform the proposed activities were included.	Volunteers with a history of forearm injury that compromised muscle integrity; or who had a history of fractures in the wrist and fingers, upper limb pain; hypertensive patients; heart disease; cognitive impairment; manual workers; and practitioners were excluded of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-8bkkp6	Electrical stimulation of the tibial nerve in women with urinary loss: Randomized clinical trial	Recruiting	Intervention	2019-10-22	<NULL>	<NULL>	3115	Effect of different currents of electrostimulation in the tibial nerve in women with urinary incontinence: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual Paulista, Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8bkkp6	<NULL>	For the present study, all women who present complaints of Bladder Hyperactivity with increased urinary frequency, nocturia or urge-incontinence; negative diagnosis for low urinary tract infections; mixed urinary incontinence.	Criteria for non-inclusion will be cognitive deficit; psychiatric disorders; pregnancy; diagnosis of neurogenic bladder; prolapse of pelvic organs above grade II; ongoing urinary tract infections; use of anticholinergic drugs; calcium antagonists, beta-antagonists, and dopamine antagonists; those who do not sign the Informed Consent Term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2fm8j9	The role of intestinal bacteria in obese patients with cardiovascular risk (metabolic syndrome)	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3116	Role of the Intestinal Microbiota for management of Metabolic syndrome and Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Faculdade de Medicina da Universidade São Paulo	Faculdade de Medicina da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2fm8j9	<NULL>	Receivers: Caucasian women between the ages of 18 and 60 with a Body Mass Index (BMI) between 30 and 40 kg / m2 - obesity grade I and II - who meet the 2005 International Diabetes Federation (IDF) criteria for metabolic syndrome.	"Receptors: patients with comorbidities that may interfere with data evaluation, use medications for metabolic syndrome, use antibiotics / pro-biotics in the past 90 days, previous cholecystectomy surgery, or have recent weight changes. Patients who refuse to participate in the study or who do not sign any of the terms of consent will also be excluded.
	Donors: donors who have received antibiotics for the last three months, who have risky sexual behavior"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-248jys	Efficacy of 4% Articaine anesthesia in the buccal region of the mandible with the Infiltrative Technique	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3117	Anesthetic efficacy of 4% Articaine with 1: 100.000 Epinephrine by the Vestibular Infiltration Technique	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual de Maringá - UEM	Universidade Estadual de Maringá - UEM	https://ensaiosclinicos.gov.br/rg/RBR-248jys	<NULL>	Painful symptomatology in one or more mandibular molars; symptomatic irreversible pulpitis; ASA I and ASA II patients; teeth that can be isolated and rehabilitated	Patients under 18 years of age; pregnant and lactating women; allergic to local anesthetics; using drugs that alter the pain threshold; teeth with open apex; root fracture; absence of lip numbness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-67gq6k	It is possible to make skin contact with skin and breastfeeding in women with caesarean section	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3118	Skin contact with scheduled caesareans and a companion. Utopia or reality	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-67gq6k	<NULL>	Women of 20-40 years inserted in the surgical list from May to May for cesarean section of the Virgen Macarena University Hospital in Seville with fetal presentations not compatible with vaginal delivery; disproportion of the pelvic head that prevents vaginal delivery; women with previous or marginal placentas that prevent vaginal delivery; previous or iterative caesarean sections that contraindicate vaginal delivery; progression failures; women whose newborn does not require the assistance of a pediatrician because the newborn will be evaluated immediately after caesarean section by the neonatology as a healthy child and the assessment of the Apgar test at 5 minutes will be 9 or 10; caesarean section between 37 and 41 weeks of gestation; controlled pregnancy where no fetal alterations or malformations have been appreciated; the mother had initially decided to breastfeed her baby and must sign the informed consent stating her desire to participate in the study	Women who for various reasons; by their own decision; due to complications do not make skin contact with immediate skin; women with complications during cesarean operation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7s5vfn	The use of Medicinal clay for the treatment of Low back pain	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3119	Geotherapy and Non-specific Low back Pain: an application study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-26	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7s5vfn	<NULL>	Be at least 18 years old and at most 59 years old; have low back pain; to be a student and / or collaborator of UNISUL or to be in the queue of the Clinical School of Naturology.	Present lesions on the skin, where the clay poultice will be applied; use of topical medicines in the region where the modality will be applied; use chronic opioid pain medications that exceed 500mg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-4kzgt4	Effectiveness of bleaching with carbamide peroxide using sonic ativation and genetic toxicity	Data analysis completed	Intervention	2019-10-22	<NULL>	<NULL>	3120	Effectiveness of bleaching with 37% carbamide peroxide with and without sonic activation and genotoxic effect: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4kzgt4	<NULL>	Patients included in this clinical trial were men and women over 18 years; who were in good general and oral health; with six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients were excluded; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2md9kk	Impact of a non-dietary nutritional approach on outpatient obese women	Recruitment completed	Intervention	2019-10-22	<NULL>	<NULL>	3121	Impact of intuitive eating program on obese women with ambulatory follow-up: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-26	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-2md9kk	<NULL>	Being with BMI between 30 and 39.9kg / m²; female; age between 20 and 59 years; patients in the first consultation in the outpatient clinic.	"People with diabetes mellitus; heart disease; renal disease; hypothyroidism; hyperthyroidism; cancer; psychotic disorders;
binge eating; Being on medications that interfere with weight and / or appetite, such as appetite suppressants and thyroid hormones;
Be pregnant, breastfeeding or in a period of up to six months postpartum; Chronic alcoholic; People practicing supervised regular physical activity at the time of
screening; People performing nutritional follow-up at another health unit during the study period. Termination criteria: Participants who by their own choice attend less than fifty percent of the outpatient appointments scheduled; Participants who decide to withdraw their free consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-94529v	Effects of exercise and athletic tape in patients with lumbar disc herniation	Recruiting	Intervention	2019-10-22	<NULL>	<NULL>	3122	Effects of segmental stabilization and functional elastic bandage in patients with lumbar disc herniation	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-06-04	SOBEU - Associação Barramansense de Ensino	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-94529v	<NULL>	Both genders; age between 18 and 59 years; lumbar disc herniation proven by computed tomography or nuclear magnetic resonance; pain 3 cm or more according to the numerical pain scale (NDE) for at least 3 months; not being under physical therapy	Under 18 and over 59 years old; pain less than 3 cm according to the numerical pain scale (NDE); pain for less than 3 months; previous spinal surgeries; neurological disorders; asymptomatic, extruded, thoracic or cervical herniated disc; impediment to perform the exercises; cognitive inability to participate in the evaluations or perform the proposed treatments; allergic processes of the bandage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-74srwz	Dual-layer stent versus close cell-stents: a carotid angioplasty stenting randomized trial	Recruitment completed	Intervention	2019-10-23	<NULL>	<NULL>	3123	Randomized double-blind clinical trial of carotid angioplasty with distal cerebral protection filter comparing closed-cell stent with double-layer stent	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Hospital de Clínicas de Ribeirão Preto - Universidade de São Paulo	Hospital da Cidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-74srwz	<NULL>	Patient over 18 years of age; Life expectancy greater than 1 year; Internal carotid artery stenosis&gt; or = 70% associated with ipsilateral symptoms such as TIA, stroke or retinal ischemia; Internal carotid artery stenosis&gt; or = 70% asymptomatic	"Contraindication for antiplatelet therapy;
Contraindication for use of iodinated contrast media;
Patients with stroke or TIA classified by A-S-C-O as C1 or O1, that is, they present mitral stenosis; prosthetic heart valve; AMI in the previous 4 weeks; mural thrombus in the left chambers; left ventricular aneurysm;
documented history of chronic or transient AF or flutter with or without &quot;spontaneous echo contrast&quot;; thrombus in the left atrium; sinus node disease syndrome; dilated cardiomyopathy; FE &lt;35%; endocarditis; intracardiac mass; patent foramen ovale plus thrombosis in situ; FOP plus concomitant pulmonary embolism or DVT and preceding cerebral infarction; dolicectasis complicated with aneurysm; polycythemia vera, thrombocytosis&gt; 800,000; LES; criteria for SAAF; Fabry disease; sickle cell anemia; ruptured cerebral aneurysm, with or without demonstration of spasm in the cerebral infarct territory; homozygous for hyperhomocystinuria; acute arterial dissection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7bwj6r	Effect of Acupuncture on Leukopenia and Language Appearance in Women with Breast Cancer during Chemotherapy: Randomized Clinical Trial	Recruiting	Intervention	2019-09-26	<NULL>	<NULL>	3124	Effect of Acupuncture on the Mononuclear Fraction of Peripheral Blood and Language Aspect in Women with Breast Cancer During Chemotherapy: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-28	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7bwj6r	<NULL>	Breast cancer diagnosis; adjuvant and neoadjuvant treatment with anthracyclics and minimum age of 18 years.	Previous history of leukopenia; metastatic disease; other cancers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-595x7r	The effect of virtual reality on the static and dynamic balance of stroke patients.	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3125	The Effect Of Virtual Reality on the Static and Dynamic Balance on Patients with Stroke.	<NULL>	4, single-arm-study, double-blind	4	<NULL>	<NULL>	<NULL>	2019-07-01	Financiamento próprio	Financiamento próprio	https://ensaiosclinicos.gov.br/rg/RBR-595x7r	<NULL>	Individual with stroke; chronic; static and dynamic balance deficit.	Individuals with acute stroke; individuals without static and dynamic balance deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-6xkcrw	Effects of positioning the newborn on the hammock in the Neonatal Intensive Care Unit to improve pain, stress and development.	Not yet recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3126	Effects of Hammock Positioning in the NICU for pain relief and stress and improvement of motor development	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado de Santa Catarina	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-6xkcrw	<NULL>	preterm newborn (gestational age less than 37 weeks) admitted to the intensive care unit; Low or extremely low birth weight newborn (under 2500g)admitted to the intensive care unit; chronological age greater than 24 hours of life; respiratory and hemodynamic stability; without continuous sedation and / or use of amines.	show signs or symptoms of neurological disorders; malformations; grade 2 or more of peri-intraventricular hemorrhage; severe heart disease; severe respiratory distress, immediate postoperative; phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-3snw7t	Influence of wearing glasses to filter blue light in the nighttime period on the perception of sleep quality and clinical parameters of critically ill patients	Not yet recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3127	Influence the  blue light filter in the nighttime period on the perception of sleep quality and clinical parameters of critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3snw7t	<NULL>	The sample will be composed of patients older than 18 years; who suffered a primary event of acute myocardial infarction with or without supra-level ST tracking; hospitalized to an intensive care unit; with a minimum score of 14 points in the Glasgow Coma Scale; with a stay of at least 12 hours in the unit, without cognitive impairment; in spontaneous ventilation or using noninvasive ventilatory support	Blind patients of the quiasmatic type will be excluded. Also excluded are patients who are in Killip IV; sedata; inpatient women without the use of delayed bladder catheterization;  inincontinent men without the use of delayed bladder catheterization and who do not adapt to the use of a non-invasive device for urine collection (Uripen®); patients who have predictors related to sleep apnea such as: Body Mass Index (BMI) greater than  35; Score greater than 10 on the Epworth daytime sleepiness rating scale; Snoring; witnessed apneas; wheezing that suffocates the night; unfavorable clinical outcome (hemodynamic and respiratory instability); confirmed diagnosis of sleep apnea and patients who were discharged during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7c4wys	Postoperative hematimetric evaluation of total knee arthroplasty with and without suction drain	Recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3128	Postoperative hematimetric evaluation of total knee arthroplasty with and without suction drain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Faculdade Ciências Médicas de Minas Gerais	Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7c4wys	<NULL>	Participants diagnosed with primary or secondary arthrosis in at least one knee joint with clinical indication (refractory pain, flexion-extension range of motion restriction and / or joint instability) and radiological (knee osteoarthritis grading systems): Alback, modified by Keys III and / or kellgren-Lawrence II) for total knee arthroplasty surgery.	Have a diagnosis of mild primary arthrosis of the knee (Alback, modified by Keys less than III and / oukellgren-LawrenceI) without indication for substitute surgery; have hematological diseases; inflammatory arthropathies be a candidate for revision total knee arthroplasty (second total knee arthroplasty); being medicated with anticoagulant; have post traumatic knee arthrosis with previous synthesis surgeries; have indication of bilateral total knee arthroplasty at the same surgical time; besides the patients who, despite being selected, had insufficient data collection to evaluate the outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7ms43m	Comparative evaluation of the mandible head / mandibular fossa relationship in patients with symptomatology or not in two positions by computed tomography	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3129	Comparative evaluation of the mandible head / mandibular fossa relationship in asymptomatic and symptomatic adult individuals in the centric and maximal intercuspal clearance through cone beam computed tomography	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7ms43m	<NULL>	To participate in the study, besides belonging to the pre-established age groups for each group of this study, the individuals of the sample should present all dental elements (the presence of third molars being optional) and the absence of previous report of unilateral or bilateral articular ankylosis. or significant trauma in the TMJ region.	The criteria used to exclude any individuals from participation in this research were: previous orthodontic treatment, signs of advanced periodontal disease, subjects undergoing previous occlusal adjustment, history of facial trauma, systemic diseases with anatomical degeneration of the mandible or mandibular fossa, trismus. and teeth with active caries process that can cause odontogenic pain. These criteria were determined with the objective of eliminating factors that could mask the initial conditions, introduce etiological and / or iatrogenic factors or prevent the implementation of the methodology present in this work. RDC / TMD exclusion factors such as myospasm, myositis, muscle contracture, polyarthritis, acute traumatic injuries, and temporomandibular joint infections were also used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7w8txn	Use of electrostimulation with Russian current to treat lumbar pain	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3130	Analysis of the efficacy of the Russian current in the treatment of lower back pain through muscle hypertrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7w8txn	<NULL>	The study included sedentary female individuals; with a maximum age of 30 years; height 1.70 m; weight 75.0 kg and BMI 25 kg/m2; who presented chronic non-specific low back pain (presence of low back pain for at least 12 weeks); with a convenience sample	Individuals with surgeries in the lumbar region; skin lesions in the region to be stimulated; pregnant women; diagnosis of neurological or musculoskeletal problems (others than chronic lumbar pain); and the performance of physiotherapeutic treatment in the last three months from the day of the evaluation were discarded; besides the non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2x8xh8	A placebo-controlled study of Ipatasertib in combination with Atezolizumab and Paclitaxel as a treatment for patients with advanced breast cancer	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3131	A phase III, double-blind, placebo-controlled, randomized study of Ipatasertib in combination with Atezolizumab and Paclitaxel as a treatment for patients with locally advanced unresectable or metastatic triple-negative breast cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-17	Hospital Perola Byington	Hospital Perola Byington	https://ensaiosclinicos.gov.br/rg/RBR-2x8xh8	<NULL>	Women or men with 18 to 65 years with locally advanced unresectable or metastatic triple-negative adenocarcinoma of the breast who have not received prior systemic chemotherapy in this setting may be eligible for this study.  In patients with BRCA-associated tumors, platinum chemotherapy as potentially the preferred treatment option should be taken into consideration when determining whether this study may be appropriate for these patients.  Patients may have received prior chemotherapy in the neoadjuvant or adjuvant setting if treatment was completed at least 12 months prior to randomization. Locally advanced unresectable disease must not be amenable to resection with curative intent.  Patients must have sufficient tumor tissue and comply with all eligibility criteria to be enrolled. Signature (s) of Free and Informed Consent (s) signed; Women or men, aged 18 or over at the moment of signing the Informed Consent Term; Provision and ability to conduct all assessments related to the study, including PRO assessments, in the investigator&apos;s judgment; Measurable disease according to RECIST (Pre-irradiated lesions may be considered as measurable disease only if the progressive disease has been unequivocally documented at that location since the radiation.); Functional Capacity of 0 or 1 according to the Collaboration Group in East-American Oncology; Adequate hematological and organ function within 14 days before the first treatment of the study on Day 1 of Cycle 1; Life expectancy of at least 6 months; For women of childbearing potential: agree to remain abstinent or use contraception and agree to refrain from donating eggs; For men agree to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods and agree to refrain from donating sperm, a histologically documented triple-negative breast adenocarcinoma that is locally advanced or metastatic and is not amenable to resection with curative intent;  Dispatch of a formalin-fixed and paraffin-embedded tumor tissue block (FFPE) or at least 15 freshly cut serial tumor blades not stained from the most recently collected tumor tissue (for PD-L1 status and other secondary and exploratory assessments required by the Protocol). Cytology or FNA samples will not be acceptable. Tumor tissue of bone metastases that is submitted to decalcification will not be acceptable; If a more recent sample is insufficient or unavailable, a patient may still be eligible if the patient can provide a block of tissue (preferred) or at least 15 unblotted serial slides of an older tumor archived tissue or is willing to consent and undergo an extra thick or excisional needle biopsy of the non-target lesion on pre-treatment (if it is accessible and the biopsy can be safely obtained). In general, at least three biopsies per thick needle will be required;	Inability to adhere to study and follow-up procedures; History of malabsorption syndrome or other condition that would interfere with enteral absorption or result in inability or unwillingness to swallow pills; Active infection requiring systemic antimicrobial treatment (including antibiotics, antifungal agents and antiviral agents); Known HIV infection (there should be a negative HIV test at screening); A clinically significant history of liver disease consistent with Child-Pugh B or C Class including active viral hepatitis or other hepatitis, current drug / drug or alcohol or cirrhosis abuse; Current treatment with antiviral therapy for HBV; Large surgical procedure, open biopsy or significant traumatic injury within 28 days prior to Cycle 1 Day 1 or anticipated need for a large surgical procedure during the study; Placement of a vascular access device will not be considered a major surgery; Pregnancy or lactation or intention to become pregnant during the study or within 28 days after the final dose of ipatasertibe / placebo, 5 months after the final dose of atezolizumab / placebo and 6 months after the final dose of paclitaxel, whichever occurs later; Class II, III or IV heart failure according to the New York Heart Association, ejection fraction left ventricle less than 50% or active ventricular arrhythmia requiring medication; Unstable angina present or history of myocardial infarction within 6 months before Day 1 of Cycle 1; Congenital long QT syndrome or QT interval corrected by the Fridericia formula (QTcF) at screening more than 480 ms; History or presence of an abnormal ECG that is clinically significant in the investigator&apos;s opinion (including complete left bundle branch block, second or third degree heart block or evidence of prior myocardial infarction); Need for chronic corticosteroid therapy more than 10 mg prednisone per day or equivalent dose of other anti-inflammatory corticosteroids or immunosuppressive agents for a chronic disease; Any other disease, metabolic dysfunction, physical examination findings, or clinical laboratory findings that in the investigator&apos;s opinion lead to reasonable suspicion of a disease or condition that contravenes the use of a investigational drug or that may affect the interpretation of the results or puts the patient at high risk for treatment complications; History of or known presence of brain or spinal metastases as determined by computed tomography (CT) or magnetic resonance imaging (MRI) evaluation during screening or previous radiographic evaluations; Any previous systemic therapy for locally advanced or metastatic triple inoperable breast adenocarcinoma; Patients who have received palliative radiotherapy for peripheral sites;Pleural effusion, pericardial effusion or uncontrolled ascites; Known hypersensitivity or contraindication to any component of the study treatments, including the excipient of paclitaxel, macrogolglycerol ricinoleate; Peripheral neuropathy Grade greater than or equal to 2; History of Type I or Type II diabetes mellitus requiring insulin; History of or autoimmune disease or active immunodeficiency including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener&apos;s granulomatosis, Sjögren&apos;s syndrome, Guillain- Barré or multiple sclerosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-7dc5mh	Physiotherapy on the risk of fall in the elderly	Data analysis completed	Intervention	2019-10-10	<NULL>	<NULL>	3132	Comparison of an aquatic physiotherapy vs conventional physiotherapy protocol in the risk of falling in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-7dc5mh	<NULL>	Seniors were over the age of 60 and had reported fall incidents in the last 6 months	The exclusion criteria involved individuals who were conducting other types of treatment that could interfere in the sample, such as osteopathic manipulative techniques; conventional physiotherapeutic treatments; recent fractures; neurological diseases; fecal or urinary incontinence; arthritis in the hips or limiting knees; severe aphasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9tzrzx	Results of the hospital care of acerto project	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3133	Acerto project: impact on hospital care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-9tzrzx	<NULL>	Participate in this study patients undergoing surgeries assisted by the team of general surgeons and who are admitted to the surgical clinic during the research period.	Patients under 18 years of age; patients from other specialties; those transferred to other sectors of the hospital and those who evaded will not be included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-5fm97x	Effect of active video games on students during physical education classes in school	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3134	Effect of exergames practice on children and adolescents during physical education classes in school	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5fm97x	<NULL>	Participation of students invited to compose the project sample will be voluntary; Inclusion criteria are no health limitations that prevent participation in exercise evaluations or protocols; Students included to participate in the study should be in the elementary or high school classes, and should be between the ages of 07 to 18 years; be able to participate regularly in the physical education classes proposed by the school.	Exclusion criteria for the research participant are: withdrawal request by the participant or guardian; presentation of some physical limitation that makes the practice of exergames impossible; attend less than 75% of classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-42nhd6	Human studies to evaluate the effect and safety of passion fruit peel extract on reducing high blood pressure	Not yet recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3135	Clinical phase II assessment to assess the effectiveness, safety and tolerability of the peel extract of Passiflora edulis in the reduction of blood pressure in patients with Arterial Hypertension stage I	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2019-07-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-42nhd6	<NULL>	both sexes; age between 18 and 60 years; distolic arterial pressure between 90 and 99 mmHg in the mean of two measurements with a 5-minute interval in the sitting position on the right brachial artery using a sphygmomanometer; systolic blood pressure lower than 160 mmHg;  never had treatment for hypertension; agree to participate in the study with the signature of the TCLE	secondary hypertension; diagnosis of fasting diabetes or glycemia greater than 120 mg/dL; kidney disease with creatinine&gt; 2 times the upper limit of normal; obesity defined by a body mass index&gt; 30 kg / m2; endocrine diseases (hyperaldosteronism, hypercortisolism, hyperthyroidism, pheochromocytoma); liver disease with ALT or AST&gt; 2 times the upper limit of normal; peptic ulcer in the last 3 months; severe respiratory failure; hemorrhagic disease; Neoplasia and user of intravenous substances; pregnant or nursing women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-8xk2rg	Outcome of a type 2 Diabetic Multiprofessional Team Intervention Program	Recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3136	Impact of a Multiprofissional Intervention Program on patients with recent Diabetes diagnosis type 2	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-10-20	Universidade Federal do Mato Grosso do Sul	Universidade Federal do Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8xk2rg	<NULL>	Patients with type 2 diabetes mellitus; age over 18 years; 3 to 6 years of diagnosis; waist circumference greater than or equal to 80 for women and greater than or equal to 94 for men; on insulin or oral hypoglycemic agents; with medical clearance for the practice of moderate intensity physical activity, walking modality, registered in the UBS of the study.	Users who do not have conditions of effective oral communication or who are diagnosed with mental disorders (recorded in the medical record), which could compromise the understanding of the information or intervention used, users with clinical conditions that prevented them from performing regular physical activity (such as problems). neurological, vascular, orthopedic or other motives) or with the presence of diabetic neuropathy (diabetic foot examination), diabetic retinopathy and diabetic nephropathy, presence of viral hepatitis B and C in diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-38dgqc	Evaluation of Microbiology, Immunology and Gene expression in Pulp infections	Recruitment completed	Observational	2019-10-25	<NULL>	<NULL>	3137	Microbiological evaluation, endotoxin quantification and analysis of immunological expression and polymorphism of endodontic infections	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-12-14	Programa de pós graduação em Odontologia do Instituto de Saúde de Nova Friburgo	Programa de pós graduação em Odontologia do Instituto de Saúde de Nova Friburgo	https://ensaiosclinicos.gov.br/rg/RBR-38dgqc	<NULL>	Will be included older patients who wanted to participate in the research will be included; need for endodontic intervention or extraction for primary endodontic infection; presence of periapical injury	Patients who do not agree to sign the free and informed consent form; used antifungals, analgesics, anti-inflammatory drugs and antibiotics in the last 3 months, with endodontic lesions associated with periodontal disease, secondary endodontic infections, teeth with spontaneous pain, root fracture, pulp chamber exposure, impossibility of absolute isolation, curved channels, atresics. or calcified.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-6kr745	Evaluation of new toothpaste formulations for total denture cleaning	Recruiting	Intervention	2019-10-28	<NULL>	<NULL>	3138	Evaluation of experimental dentifrices based on essential oils for total prosthesis hygiene - in vitro and in vivo studies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Faculdade de Odontologia de Ribeirâo Preto	Faculdade de Odontologia de Ribeirâo Preto	https://ensaiosclinicos.gov.br/rg/RBR-6kr745	<NULL>	Inclusion criteria will be: total toothless individuals of any age; both genders; with good overall health;users of superior total dentures for at least one year and with presence of prosthetic stomatitis in the upper arch. As for prostheses must be made with acrylic resin base and artificial teeth and be in good conditions of use, and with the presence of biofilm on the inner surface according to the Additive Index.	Will be excluded individuals who have used antibiotics in the past three months or users of prostheses with products for denture rebasing, repairs or fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-4syyz2	The effect of an intervention for nurse education on tube feeding	Recruitment completed	Intervention	2019-10-28	<NULL>	<NULL>	3139	The effect of an educational intervention for nursing teaching on enteral nutritional therapy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Estadual de Campinas	Irmandade Nossa Senhora das Mercês da Santa Casa de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-4syyz2	<NULL>	Care nurses from units that treat adult patients on enteral nutritional therapy.	Distance nursing, vacation or medical leave; admitted during the study process initiated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9yrqwh	The influence of the type of anesthesia on the appearance of changes in brain activity after video surgeries, in which the patient&apos;s head is tilted downwards	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	3140	"Analysis of two anesthetic techniques in the appearance of postoperative delirium of cancer patients submitted to surgeries
of videolaparoscopy in trendelenburg position"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-18	Fundação Antônio Prudente	A.C. Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-9yrqwh	<NULL>	patients from the AC Camargo Cancer Center; aged 18 years or over; American Society of Anesthesia (ASA), less than 3, submitted to elective laparoscopic surgery in a Trendelenburg position, minimum period of 2 hours and who agree to sign the free and informed consent form.	Absolute contraindication and related to spinal anesthesia; with difficult airway prediction with possibility of awake intubation; With previous diagnosis of: cognitive disorder and / or depression; chronic use of benzodiazepines (use during the last 12 weeks); referred to perform the postoperative ICU; with diagnosis of anemia (Hemoglobin &lt;10); with diagnosis of current infection; with renal disease with stage&gt; G3a (glomerular filtration rate &lt;45 ml / min / 1.73 m2; with body mass index (BMI) characterized by obesity (BMI&gt; 30 kg / m2);with history of nausea / vomiting in previous anesthetic procedures; with diagnosis of malignant hyperthermia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-235jts	Dental sensitivity: prevalence and treatment	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3141	Cervical dentin hypersensitivity: prevalence and treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-235jts	<NULL>	Orto1 study: patients older than 18 years; completed corrective orthodontic treatment; permanent dentition erupted prior to orthodontic treatment; agree to participate; good general health. Orto2 study: patients older than 18 years; completed corrective orthodontic treatment; permanent dentition erupted prior to orthodontic treatment; agree to participate; good general health; clinically diagnosed dentin hypersensitivity. Perio1 study: patients older than 18 years; completed non-surgical periodontal treatment; agree to participate; have good general health. Perio2 study: patients older than 18 years; completed non-surgical periodontal treatment; agree to participate; good general health; clinically diagnosed dentin hypersensitivity.	Orto1 study: in orthodontic retreatment; use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentin hypersensitivity. Orto2 study: in orthodontic retreatment; use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentine hypersensitivity; allergic to the components of the formulations that will be used. Period study1: use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours before clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentin hypersensitivity. use of anti-inflammatory, analgesic and / or psychiatric medications (chronic or up to 72 hours prior to clinical evaluations); pregnant or lactating women; carious lesions; endodontic treatment; pulp and / or periapical lesion; in treatment for dentin hypersensitivity; who underwent periodontal surgery in the last 3 months; restored in the last 3 months; fixed or removable prosthetic abutments; with prosthetic crowns; extensively restored; restorations covering the cervical region and / or regions that interfere with the assessment of dentine hypersensitivity; allergic to the components of the formulations that will be used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-28jpfd	Flexibility, Strength, and Balance of Menopausal Women Practicing Exercise	Recruitment completed	Intervention	2019-10-29	<NULL>	<NULL>	3142	Flexibility, Muscular Strength, and Balance in Physically Active Climatest Women and Menopause	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-29	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-28jpfd	<NULL>	Inclusion criteria are all female participants in menopausal climacteric period between the ages of 45 and 65, who are able to perform exercises that were hemodynamically stable and participants in the extension project.	Women who had a severe chronic disease with a blood glucose lower than 70 mg / dl or higher than 250 mg / dl and a blood pressure greater than or equal to 120 mmhg were excluded and who were unable to perform the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-5qp73j	Acute effect of Physiotherapy on patient&apos;s blood cells after Fracture Fixation Surgery	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3143	Acute effect of Physiotherapy on Cell Markers of Postoperative Fracture patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-14	Universidade Feevale	Fundação de Saúde Pública de Novo Hamburgo	https://ensaiosclinicos.gov.br/rg/RBR-5qp73j	<NULL>	Age between 18 and 59 years old; both sexes; first postoperative day of lower limb fracture fixation; Clinically stable; Making use of anti-inflammatory medication	Ribs fractures and / or upper limbs and / or preventing the intervention; diagnosis of rhabdomyolysis; limitations that prevent exercises performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-6pncm9	Melatonin assessment on sleep and metabolism of overweight night workers	Recruitment completed	Intervention	2019-10-29	<NULL>	<NULL>	3144	Effect of melatonin on sleep and metabolism of overweight night workers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pncm9	<NULL>	Women; age 20-50 years; body mass index less than ou equal to 25.0 and less than 40.0 kg/m²; working for at least six months on the current night shift; commiting not to change eating or physical activity habits while participating in the study.	Pregnant women; lactants; having children under one year old; eating disorders diagnosed by a doctor; holding a second night shift job; body mass index less than 25.0 or more than or equal to 40.0 kg/m²; regular use of medications or supplements that influence sleep, alertness and the circadian timing system (barbiturates, antidepressants, benzodiazepines, soporifics, melatonin, methylphenidate, modafinil); past history of neurological or psychiatric disorders, drug and/or alcohol abuse, sleep-wake cycle disorders, cardiovascular disease (excess treated systemic arterial hypertension), metabolic problems (except treated dyslipidemia and type 2 diabetes mellitus), inflammation and/or physician-diagnosed chronic infections; having had anemia or donated more than 400 ml of blood in the last three months prior to study participation; having had major surgery in the last six months prior to participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-38krf2	Exercise and pain education in individuals with chronic pain	Not yet recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3145	Physical therapy for muscle strengthening and endurance associated with pain education	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-38krf2	<NULL>	Pain for at least three months; intensity of at least 3 on the Visual Analogue Scale (VAS); clinical diagnosis of dysfunction to the musculoskeletal system; not undergoing any treatment or physical activity at the time of admission to the study	History of central lesion; cognitive disorders that compromise the understanding of the procedures or that affect motor control; cardiovascular and / or respiratory alterations that are not under clinical follow-up or that compromise the exercise; surgical procedure in the area of pain; pregnant women; malignant tumor; absolute contraindication to general exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9wk8rq	Heart rate variation in newborns exposed to melody during fetal period	Data analysis completed	Intervention	2019-10-29	<NULL>	<NULL>	3146	Heart rate in newborns exposed to melody during fetal period – controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Instituto de Medicina Integral Prof Fernando Figueira	Instituto de Medicina Integral Prof Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9wk8rq	<NULL>	Newborns between 3 and 47 days whose mothers listened to the melody according to study methodology; Newborn with good vitality at birth; Healthy newborns; Term newborn.	Post term newborns; Preterm newborns; Newborns over 47 days old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-7s9rw2	Performance of children playing football in games	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3147	Analysis of motor performance in virtual reality tasks in football practicing children	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2018-12-12	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s9rw2	<NULL>	Healthy volunteers, age range between 07 and 17 years; Playing soccer for at least 1 year; for at least 2 times a week.	Presence of neurological or orthopedic diseases in the period of occurrence; Significant acute illnesses; Difficulty playing computer games due to motor limitations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9yrnbg	Use of a substance to prevent and control mouth inflammation caused by radiotherapy	Data analysis completed	Intervention	2019-10-29	<NULL>	<NULL>	3148	Use of Glutamine in the prevention and control of Radio Induced Oral Mucositis	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2010-10-16	Universidade Estadual da Paraíba	Daliana Queiroga de Castro Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9yrnbg	<NULL>	Patients of both sexes; regardless of ethnicity; over 18 years of age; undergoing head and neck radiotherapy with at least half of the oral mucosa area included in the radiation fields.	Patients submitted to palliative RT; those who could not open their mouths; and those who used prophylactic topical drugs or mouth rinse; and those who presented Karnofsky Performance Status&lt;70 were excluded; Interruption of use for just one day and not coming to the dental evaluation resulted in the elimination of the patient from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-459d4r	The effect of topical anesthesia on patients with dental anxiety	Recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3149	The comparative effect of topical anesthesia on patients with different levels of dental anxiety	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-20	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-459d4r	<NULL>	"ASA I
Need for extraction of bilateral superior third molars."	"Patients with systemic comorbidities;
Pregnant or breastfeeding women;
Patients taking continous use medications;
Patients with a history of anemia or methemoglobinemia;
 Patients with a history of drug allergy to the drugs selected for the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-484pf5	Heart rate during games in athletes with Spinal Cord Injury	Recruiting	Observational	2019-10-30	<NULL>	<NULL>	3150	Heart Rate Variability Modulation in Virtual Reality game in athletes with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-13	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-484pf5	<NULL>	Diagnosis of spinal cord injury; Agree to participate in the research; Present preserved motor activity for extension of upper limbs; Display active trunk control	Have functional disabilities that make collection impossible; missing one or more collection days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-383vcp	Use of Intranasal Oxytocin during Detoxification of Crack/Cocaine	Recruiting	Intervention	2015-09-21	<NULL>	<NULL>	3151	Protection targets to women crack users	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-05	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos Estratégicos	https://ensaiosclinicos.gov.br/rg/RBR-383vcp	<NULL>	"For both groups: female; age 18-50 years; absence of menopause; with right-handed manual dominance; HIV-; no metals in the body; no recent tattoo (2 months), BHCG -; declare abstainers from non-tobacco drugs in the last 2 weeks; no evidence of claustrophobia, no history of eye, ear and brain surgery; no administration of benzodiazepines and neuroleptics in the last 24 hours; no history of head trauma, literate.
For the control group: Declare no substance-related disorder.
For the case group: Diagnosis of cocaine-related disorder (crack) according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition."	Controls reporting on use of psychiatric medications; positive urine test for cocaine, benzodiazepine, amphentamine, opioids and alcohol; illiterate; Psychotic syndromes; have been pregnant for the past 6 months; have an IQ &lt;70; neurological disease; metal prostheses; and / or tattoos or other metallic artifacts that make magnetic resonance imaging unfeasible. Possess claustrophobia; chronic respiratory disease; deviated septum type III; presence of lesions in the nasal mucosa; history of head injury; or currently have nasal congestion. Healthy group participants with ongoing mental disorders; crack users who have declared themselves abstinent for more than two months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-78vysg	Clinical trial for the subcutaneous recombinant human erythropoietin biosimilar in healthy adult male population	Not yet recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3152	Phase I, monocentric, open-label clinical trial to determine the pharmacokinetics and pharmacodynamics of subcutaneous recombinant human erythropoietin in healthy adult male population	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-02-10	Laboratório Daudt Oliveira Ltda.	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-78vysg	<NULL>	Informed Consent Form approved by IRB signed; male; age between 18 and 55 years; be characterized as a healthy research participant from medical history, general physical examination and vital signs, laboratory tests and ECG indicating no evidence of disease; have a BMI equal or greater than 18 and equal or less than 29.9 kg/m2; have a body weight of 60 - 100 kg; normal iron metabolism tests	Cardiovascular disorders and BP greater than 145/90 mmHg; history of venous thrombosis; presence of iron deficiency anemia or clinical history of autoimmune or hereditary anemia; clinical history of chronic or acute bleeding in the 30 days before the start of the trial; prior erythropoietin therapy; signs or clinical history of spinal cord aplasia; changes in the electrocardiogram that, at the physician&apos;s discretion, does not recommend the participant&apos;s stay in the trial; have a history of excessive alcohol consumption for at least 6 months prior to the trial (drinking 5 or more alcoholic beverages in one day or 15 or more alcoholic beverages per week); be a smoker or have quit smoking for less than 6 months; participant who consumes 5 or more cups of tea or coffee per day and cannot abstain during the trial period; participants with chronic diseases; hypersensitivity or contraindication of using the components of the medications studied; blood donation (more than 500 mL) or major surgery within 3 months prior to signing the Informed Consent Form; participation in clinical trial protocols in the last 12 months; any clinical condition or laboratory abnormality which, at the discretion of the investigator, could compromise trial participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-8ddc92	Study of different types of physical training in people living with HIV	Recruitment completed	Intervention	2019-10-30	<NULL>	<NULL>	3153	Physiological and immunological responses of different models and intensities of Exercise in acute and chronic period of training in people living with HIV	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8ddc92	<NULL>	The inclusion criteria for the study will be: to present a positive serology for the HIV virus and to be using ART for at least 6 months (closed to the HIV- group); be physically enabled (without any motor impairment) to perform the tests and trainings; have no severe disease; be between 18 and 60 years of age; present the cardiological medical certificate for the practice of physical exercises.	The exclusion criteria adopted for both groups (HIV + and HIV-) will be: present diarrhea, nausea, vomiting or poor oral intake of food; have had systemic infection within 30 days; pregnancy or have a presence of less than 85% of the training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-8yfq4g	Effects of classic mat pilates exercises performed on the ground, with Ballet Barre exercises, performed standing, on postural control strategies.	Recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3154	Effects of regular lumbopelvic stability exercise on postural control strategies	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-09-30	Universidade de São paulo	Universidade de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-8yfq4g	<NULL>	Inclusion criteria over 19 years;  low back pain for at least 12 weeks; pain scale between 3 and 7 by the Rolland-Morris questionnaire.	"As exclusion criteria medical contraindication that presents some risk; physical and / or mental disability; fracture; or serious soft tissue injury in the 6 months prior to the study; as well as history of neurological; cardiovascular or respiratory alterations; vestibulopathies and peripheral neuropathy; high blood pressure; diabetes or any uncontrolled chronic disease. Being in rehabilitation treatment (acupuncture; physical therapy; global posture rehabilitation; pilates; yoga and others).
Individuals with low back pain classified as &quot;severe disability&quot;; according to the questionnaire translated and validated in Portuguese Rolland Morris; whose sum is equal to or greater than 14 points; which indicates severe disability. (Mascarenhas, 2011)
Unwillingness to complete study requirements;  or to be randomized into intervention groups; more than two absences."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-44jkr3	Study to detect Raynaud&apos;s phenomenon in a healthy population in the Midwest region of Brazil with assessment of patient&apos;s finger circulation through videocapilaroscopy examination	Recruiting	Observational	2019-10-30	<NULL>	<NULL>	3155	Study of the prevalence of Raynaud&apos;s phenomenon in a healthy population in the midwest region of Brazil with morphological and anatomical evaluation of patients&apos; microcirculation through videocapilaroscopy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-29	Hospital de Base do Distrito Federal	Hospital de Base do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-44jkr3	<NULL>	Brazilians; employees of the Federal District Health Department; age 18 to 65 years	over 65 years old; under 18 years old; foreigners; patients with rheumatic connective tissue disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-3mvbsk	Better living: impacts of Therapy For Exercise in the health of elderly	Recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3156	Effects of the volume and intensity of the Physical Exercise, comparing the complexity of the Motor Task on the cognitive capacity of elderly persons with Mild Cognitive Impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Universidade do Oeste de Santa Catarina - Unoesc	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-3mvbsk	<NULL>	Individuals aged 60 years and over; with mild cognitive impairment or early dementia; medical health service monitoring; who voluntarily agree to participate in the study will be considered eligible.	Exclusion criteria involve elderly patients with cardiovascular impairments; musculoskeletal or visuospatial limitations that may contraindicate or present discomfort to the exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-5mv7jd	Effects of the consumption of white or red grape juice in the muscular damage of rugby athletes	Recruitment completed	Intervention	2019-10-31	<NULL>	<NULL>	3157	Effects of consumption of white or red grape juice on oxidative stress and muscular fatigue in rugby athletes: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-02	Centro Universitário Metodista	Centro Universitário Metodista	https://ensaiosclinicos.gov.br/rg/RBR-5mv7jd	<NULL>	Male players will be included, aged between 20 and 30 years and at least 1 year play as holders of the rugby team of Caxias do Sul / RS and have daily training routines, between the game itself and physical training.	Injured athletes who are out of training and / or competing in the past six months, athletes using anti-inflammatory drugs, and athletes who have an aversion or allergy to the components of grape juice will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-2c4xxb	Effects of grape juice consumption improvements in functionality and cognition of individuals with Parkinson&apos;s disease who perform aquatic physiotherapy	Recruitment completed	Intervention	2019-10-31	<NULL>	<NULL>	3158	Effects of grape juice consumption on biomarkers, functionality and cognitive function of individuals with Parkinson&apos;s disease who perform aquatic physiotherapy: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2c4xxb	<NULL>	The participants with diagnosis of Parkinson&apos;s disease will be included after a confirmation by qualified professional, who accept to participate in the intervention, the included participants must regularly attend Parkinson&apos;s care in the clinic of the Southern Methodist University Center.	Any complications during the application of the intervention, or any restriction regarding the consumption of the juice.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-428w2f	"Local effect of a gel on the healing of
wounds after surgery to remove wisdom"	Recruiting	Intervention	2019-10-31	<NULL>	<NULL>	3159	Local effect of slow oxygen release on wound healing: third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-428w2f	<NULL>	Individuals who have the indication of bilateral extraction of impacted third molars.	Those individuals who do not perform bilateral extraction of affected impacted third molars, who do not subscribe to the ICCT, individuals who are allergic or intolerant to the substances used in the study, in treatment that affects blood clotting, in psychiatric treatment, pregnant or lactating women, women who do use oral contraceptives, diabetics, with periodontal disease or active infection, smokers of more than 10 cigarettes per day and individuals with poor and non-cooperative hygiene.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7sx64c	Use of testosterone cream applied to skin in women with hypoactive sexual desire and quality of life	Recruitment completed	Intervention	2019-10-31	<NULL>	<NULL>	3160	Transdermal use of testosterone nanoemulsion in women with desire hypoactive sex disorder and quality of life: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-25	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7sx64c	<NULL>	Women over the age of 18 and the maximum age of 45 who are menstruating physiologically; decrease in sexual desire; sexual activity present with at least one sexual event per month and with current partner; be in good general health; being on contraceptive method (MAC); women over 40 years of age should have a clinically acceptable mammogram within the last 2 years;	"Sexual dysfunction caused by another medical condition; body mass index (BMI) below 18 kg / m2 or above 35 kg / m2;
undiagnosed genital bleeding; androgen therapy in the last 6 months (testosterone implant, testosterone transdermal cream, oral testosterone or injectable testosterone);
 antiandrogen therapy for acne or hirsutism in the last 5 years;
moderate or severe acne, hirsutism, and androgenetic alopecia;
participant with any hyperandrogenic syndrome; any clinical illness or severe depression, active cancer, or treatment of malignancy within the last six months; pregnancy or nursing;
not attending our center for follow-up study visits"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-5x9gss	Evaluation of different restorations types in tooth with root treatment.	Recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3161	Randomized clinical trial of restoration with different direct technique in endodontically treated molars.	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-05-01	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5x9gss	<NULL>	Molars and pre-molars; Endodontic treatment; Absence of pain and endodontic complications; Contact with the antagonist;	Significant tooth loss that justify indirect restorations; Patient with bruxism; Presence of extense parcial prothesis; Total prothesis as antagonist.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-22qrch	Assessment of irritability and sensitization of health products through (patch test)	Not yet recruiting	Observational	2019-11-01	<NULL>	<NULL>	3162	Assessment of thermal irritability, accumulation and sensitization of health products by patch test _ mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-22qrch	<NULL>	"Healthy skin in the study region; Age 18 to 65 years; Gender: male and female; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation / allergy to the material used in the study; Having signed the Informed Consent Form (ICF);
Participants wishing to participate in the study without financial gain. They will be reimbursed for test-related expenses such as transportation and food"	"Participants who refuse to participate in the study in question.
Skin tags in the experimental area that interfere with the evaluation of possible skin reactions;
Active dermatoses (local and widespread) that may interfere with the study results;
Pregnant or lactating women;
History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines;
Volunteers with a history of allergy to the material used in the study;
History of atopy;
History of conditions aggravated or triggered by ultraviolet radiation;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Prediction of intense sun exposure or tanning session during the study period;
Prediction of bathing in the sea, pool or sauna during the study;
Participants who practice water sports;
Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection;
Treatment with acidic vitamin A and / or its derivatives orally or topically within 1 month before the start of the study;
Expected vaccination during the study or up to 03 weeks before the study;
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Included participants are advised not to change diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-83jr3x	Effect of consumption of a mix of dried and oiled fruits and dark chocolate (70% cocoa) on the control of cigarette craving in abstinent smokers	Recruitment completed	Intervention	2019-11-01	<NULL>	<NULL>	3163	Effect of the consumption of a mix of dried fruit and oilseeds and bitter chocolate (70% cocoa) on the modulation of craving in smokers on abstinence treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-04	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-83jr3x	<NULL>	Users of more than 20 cigarettes / day, with Systemic Hypertension (SAH) and / or Diabetes Mellitus (DM)	Poly-users of psychoactive substances, people with psychiatric illnesses or cognitive deficits, cancer, Acquired Immunodeficiency Syndrome (AIDS), those who were in nutritional follow-up, and those who did not accept or did not fulfill the aforementioned inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7sgsn5	Comparison of two techniques of separation of the Lingual Frenulum	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3164	Comparative analysis between two Lingual Frenotomy surgical techniques	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidade do Extremo Sul Catarinense (UNESC)	Universidade do Extremo Sul Catarinense (UNESC)	https://ensaiosclinicos.gov.br/rg/RBR-7sgsn5	<NULL>	Infants who have ankyloglossia and will be submitted to lingual frenotomy. In the Criciúma macroregion.	Infants aged six months or more; presence of other congenital malformations; prematurity; genetic syndromes; and mild ankyloglossia. Conditions that make it impossible to perform surgery; or the refusal of those responsible for the research participation. Patients with relapsed ankyloglossia. No signature of the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-4dx6fk	Effects of Periodontal Treatment in renal conditions	Recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3165	Effects of Periodontal Treatment in renal outcomes of Pre-Dialytic patients: randomized controlled trial of 12 months of follow-up	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-06-27	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4dx6fk	<NULL>	Stage 3 and 4 chronic kidney disease; Glomerular filtration rate lower than 60 ml / min / 1.73 m², without being in dialysis; Having more than 18 years of age; Not being HIV positive; Not having diagnosis, nor being in treatment of malignant neoplasia; Do not be pregnant or nursing; Moderate periodontitis according to the definition criteria of (2 or more interproximal sites with depth of probing of 5mm or more or 2 or more interproximal sites with loss of insertion of 4mm or more); Present at least 10 teeth present; Negative medical history of any systemic condition that necessitates the use of antimicrobial chemoprophylaxis.	Periodontal treatment in the last 6 months; Pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-4m2xk8	Restorative Treatment versus Dental Sealants in the Posterior Permanent Teeth: A Randomized Controlled Trial	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3166	Conservative Treatment of Caries Lesions in Posterior Permanent Teeth: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-4m2xk8	<NULL>	Healthy volunteers; both genders; from 12 years of age; premolars and / or permanent molars; at least one occlusal surface active caries lesion with radiographically radiolucent in the external dentin (limited to 50% in depth); cavity width that does not contra indicate sealing; absence of previous restorations on any face of the tooth.	Patients with systemic diseases that may influence their oral health; orthodontic  pacients or teeth-fixed devices selected for the study; advanced periodontal disease with poor prognosis for tooth maintenance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8qwnjg	Effects of Respiratory Physiotherapy in individuals with Kidney Disease	Not yet recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3167	Effects of Respiratory Muscle Training and Peripheral in the physical fitness of individuals with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Metodista de Piracicana	Universidade Metodista de Piracicana	https://ensaiosclinicos.gov.br/rg/RBR-8qwnjg	<NULL>	Will be included participants from 20 to 69 years, who have stage V (five) CKD; HD treatment for at least three months, three times a week; with hemodynamic stability; able to perform the evaluations and proposed training and agree to participate in the study.	Obese individuals (BMI Bigger or equal 30Kg / m2) who have a history of lung disease, decompensated heart disease, musculoskeletal and / or neuromuscular disorders that preclude the test will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8mj2qf	Homeopathy on primary care of cocaine-related disorders	Not yet recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3168	Homeopathy on primary care of cocaine-related disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-21	Prefeitura do Município de Itajaí	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-8mj2qf	<NULL>	Assist score for cocaine between 4 and 26.	Negative urinary benzoilecgonine detection (&lt; 150 ng/mL).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-6bv5hy	Comparison of the occurrence of pain after root canal treatment performed on teeth with mortified nerve with or without injury to the root of the tooth using two mechanized canal cleaning systems and two canal cleaning limits.	Data analysis completed	Intervention	2019-11-06	<NULL>	<NULL>	3169	Comparison of postoperative pain incidence in endodontic treatments performed on Pulp Necrosis teeth with or without apical lesion using two mechanized instrumentation systems and two apical instrumentation limits	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6bv5hy	<NULL>	Inclusion criteria were teeth diagnosed with asymptomatic necrosis pulp; confirmed by a negative response to pulp vitality tests with heat and cold; with or prior radiographic periapical lesion and without clinical symptoms such as pain; fistula; edema and palpation sensitivity.	We excluded from the study vital teeth, previous endodontic retreatment; teeth with open apex; teeth with periodontal problems that have periodontal probing greater than 3 mm; internal and external root resorption, dental traumatism; treatments not a single session; root canals where it was not possible to realize the patency of the apical foramen and patients allergic to some compound of the medicine ibuprofen. Also excluded were those with spontaneous pain that were included in the study; who used analgesic or anti inflammatory medication in the last ten days, who had systemic diseases and those who refused to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7gfj5r	Assessment of life habits and health status associated with Fatigue	Recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3170	Fatigue Prevention and Management in Mine Workers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Ouro Preto	Vale S A	https://ensaiosclinicos.gov.br/rg/RBR-7gfj5r	<NULL>	Workers shortlisted for the high performance operator program according to the company&apos;s operational technical criteria will be included in the study	"Operators who submit will be excluded:
Evidence of substance abuse or dependence in the last 5 years.
Non-medical psychiatric treatment at least 4 weeks before study.
Clinically significant 24-hour Holter abnormality as complex ventricular arrhythmias, defined as sustained ventricular tachycardia, second-degree mobitz type II or more atrioventricular block, sinus pauses longer than 3 seconds, presence of more than 30 episodes of extrasystoles per hour, and atrial fibrillation or flutter
Decompensated metabolic disorders such as diabetes with glycated hemoglobin (HbA1c) greater than 9% and dyslipidemia with LDL greater than 180 mg / dL or triglycerides greater than 500 mg / dL.
Degenerative chronic diseases (autoimmune, neoplasia, immunodeficient disease and neurological diseases).
Operators with signs and symptoms of infectious diseases.
Gastrointestinal disorders with altered absorption.
Carriers of moderate to severe sleep disorder
Using the following medicines: amitriptyline, clomipramine, imipramine, nortriptyline, fluoxetine, sertraline, paroxetine, venlafaxine, citalopram, lithium carbonate, valproic acid, sodium divalproate, carbamazepine, risperidone, olanzapine, haloperidol, monoaminoxpride inhibitors, moclobemide or selegiline."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-92vx4g	Study of maxillary sinus lift surgery with atraumatic techniques	Recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3171	Comparative analysis of maxilar sinus lift by the atramatic and osseodensification techniques - prospective, randomized, controlled and split mouth study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-08	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-92vx4g	<NULL>	Inclusion criteria are: bilateral edentulous patients in the posterior maxillae who require atraumatic bilateral maxillary sinus lifting; presenting a minimum of 5mm bone height (bone crest to inferior wall of maxillary sinus); willing to volunteer in accordance with the Informed Consent Form; to undergo clinical, photographic and tomographic examinations, implant installation with bilateral maxillary sinus lifting; as well as, they should commit to the clinical and tomographic follow-up returns.	Exclusion criteria are: patients with indication for implant placement only in one maxillary hemiarch; patients with indication of left and right maxillary implants, but with indication of sinus lift in only one or without indication of lift; Smoking patients; patients with systemic diseases; pregnant or lactating patients; patients who use medications that may interfere with the healing process; patients with periodontal diseases or carious and endodontic lesions; patients under 18 years and patients not committed to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8fffvv	Acute effects of Phototherapy on the Functional Capacity of patients Admitted to Hospital   Intensive Care Unit	Recruitment completed	Intervention	2019-11-07	<NULL>	<NULL>	3172	Acute effects of Photobiomodulation by Leds (light-emitting diodes) on the Functional Capacity of patients Admitted to Hospital   Intensive Care Unit	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Brasil	Associação Piauense de combate ao câncer/ hospital São Marcos	https://ensaiosclinicos.gov.br/rg/RBR-8fffvv	<NULL>	Adults (higher than 18 years old) hospitalized in  intensive care unit (ICU) of a philanthropic hospital due to postoperative cardiac surgery or acute respiratory failure	Patients with plegia, paresis, amputation or congenital deformities in at least one limb, and patients with data insufficiently described in their hospital chart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-3fwgnj	Evaluation of serum markers to differentiate high blood pressure of pregnancy from kidney disease of lupus	Recruiting	Observational	2019-11-07	<NULL>	<NULL>	3173	Evaluation of angiogenic and antiangiogenic factors for differential diagnosis of preeclampsia and systemic lupus erythematosus with nephritis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-03	Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas	Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-3fwgnj	<NULL>	Pregnant patients diagnosed with systemic lupus erythematosus between will be sequentially enrolled upon prenatal admission.	Patients who do not wish to participate in the study; multiple pregnancies; pregnancies that are interrupted before 20 weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7ycfcg	Effects of additional protein consumption on weight, musculature and quality of life of cancer patients	Recruitment completed	Intervention	2019-11-07	<NULL>	<NULL>	3174	Effects of leucine supplementation on nutritional status, sarcopenia and quality of life of cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Jessika Soares	Faculdade de Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-7ycfcg	<NULL>	Diagnosis of cancer of the esophagus, stomach, pancreas or biliary tract, attended at the oncology clinic of the hospital; in exclusive chemotherapy; decrease or deficit in food intake; with nutritional risk, evidence of fat loss and / or muscle mass, not receiving a protein supplement enriched with leucine or other branched-chain amino acids, not participating in any muscle strengthening program that agrees to participate voluntarily.	Patients without nutritional risk; presence of edema; mental disorders; cognitive or walking disability; use of pacemakers or metal parts in the body; with use of enteral therapy and / or total parenteral nutrition; absorptive dysfunctions; obstruction of digestive access and use of protein supplementation prior to study or during recruitment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7djc66	Use of intranasal oxytocin during detoxification of crack/cocaine	Recruiting	Intervention	2019-11-07	<NULL>	<NULL>	3175	Protection targets to women crack users	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2018-09-15	Secretaria Nacional de Políticas Sobre Drogas	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-7djc66	<NULL>	Volunteers; aged 18-52 years; with primary diagnosis of cocaine crack dependence according to DSM-5; female; participants must be abstinent at 7 days prior to the start of the intervention; participants must consent to be randomly allocated to experimental conditions.	Being pregnant; puerperal or nursing or menopausal; currently using hormone therapy; women who have had total hysterectomy; diagnosis or suspicion of autoimmune or neurological diseases and / or syndromes (stroke, Parkinson and Alzheimer&apos;s); diagnosis or suspected current decompensated and / or severe endocrine, cardiovascular, pulmonary, renal, gastrointestinal disorders; have moderate or severe psychotic syndrome; level III obese women; presence of intellectual impairment (IQ &lt;70); women receiving corticosteroid therapy, glucocorticoid or any exogenous steroid therapy; women with an infectious condition or acute febrile syndrome; have significant nasal congestion; have type III nasal septum deviation (cases considered severe with deviated septum in which breathing is impaired); have mucosal lesions; have a history of head trauma moderate or severe (Glasgow &lt;12); HIV +.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-5bs7dr	Oral sensitivity in patients with tongue disorders	Recruiting	Observational	2019-11-07	<NULL>	<NULL>	3176	Oral stereognosis in subjects with tongue lesions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5bs7dr	<NULL>	Presence of tongue lesions (Benign migratory glossitis, Fissured tongue and Hairy tongue); Age between 18 and 45 years; Good general health; Good cognitive status, assessed by applying the Mini Mental State Examination (MMSE); Complete permanent dentition (with optional third molar presence) and no more than one absent premolar in the quadrant.	Presence of benign or malignant lesions / neoplasms in the tongue or oral cavity in general; Presence of neuromuscular diseases; Presence of facial malformations; Severe malocclusion; Bruxism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-3d8fd2	The effects of brain current and treadmill walking on the treatment of Binge Eating	Recruiting	Intervention	2019-11-11	<NULL>	<NULL>	3177	Effects of Brain Electric Stimulation associated with Aerobic Exercise in the treatment of Food Compulsion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	NEMO-Neuromodulação cerebral	UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-3d8fd2	<NULL>	Binge-eating and overweight or obese grade I volunteers; both genders; age between 20 and 49 years old; not having been exercising regularly for at least 6 months.	Be in nutritional follow-up or intervention; women intending to become pregnant during the study period; pregnant or lactating women; history of severe depression or other severe psychiatric comorbidities; use of appetite-modulating medications; history of cardiovascular disease, kidney failure, and diabetes mellitus; body mass index outside the established criteria; impossibility to exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7p6vsr	Effectiveness of an Educative Booklet in promoting healthy lifestyle for people with HIV/Aids	Not yet recruiting	Intervention	2019-11-11	<NULL>	<NULL>	3178	Development, validation and effectiveness of an Educative Booklet in promoting healthy lifestyle in the context of Arterial Hypertension for people with HIV/Aids	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-7p6vsr	<NULL>	People with HIV/Aids; of both genders; with age above 18 years; accompanied in the outpatient clinic of infectology of Walter Cantídio University Hospital; in use of antiretroviral drugs for at least 6 months; who are able to read and understand the booklet according to the Health Literacy Scale.	Pregnancy; mental illness and medical diagnosis in medical records; be homeless, collective shelters or deprived of their liberty in penitentiaries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-9f8c78	Use of organic propolis to prevent and treat oral ulcers caused by radiotherapy in head and neck cancer patients	Recruiting	Intervention	2019-11-12	<NULL>	<NULL>	3179	"Evaluation of organic propolis types 4 and 6 as coadjuvant in the prevention
and treatment of oral mucositis in patients undergoing radiotherapy in the
head and neck region"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Faculdade de Odontologia de Piracicaba - UNICAMP	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-9f8c78	<NULL>	olunteers with primary malignant neoplasms in the mouth or oropharynx; submitted to 2D, 3D or IMRT adjuvant radiotherapy, exclusive or associated with chemotherapy	"Patients previously irradiated in the head and neck region; patients who present some type of discomfort or a history of
propolis allergy; patients who do not have minimum clinical conditions for use of propolis voluntarily"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-52bw3b	Treatment of Advanced Vaginal Prolapse: Prospective, Randomized Study	Not yet recruiting	Intervention	2019-11-12	<NULL>	<NULL>	3180	Up Hold x Splentis in the treatment of advanced Pelvic Organ Prolapse: Prospective and Randomized Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Maternidade Escola Vila Nova Cachoeirinha	Hospital Maternidade Escola Vila Nova Cachoeirinha	https://ensaiosclinicos.gov.br/rg/RBR-52bw3b	<NULL>	Adult women, over 45 years old,constituted offspring, with stage III or IV advanced pelvic organ prolapse, treated at a single referral center, at Hospital Municipal e Martenidade Escola - Dr Mário de Moraes Altenfelder Silva - Vila Nova Cachoeirinha.	Vaginal, cervical or uterine cancer; Genital system or urinary tract infection; During pregnancy; Sensitivity or known allergy to polypropylene; Hypertrophic uterine cervix; Pelvic Radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8vd2bp	The effect of Diazepam on facilitating placement of devices during Tubal Ligation procedure	Recruitment completed	Intervention	2019-11-12	<NULL>	<NULL>	3181	Effect of diazepam on facilitating the placement of devices during tubal sterilization procedure by hysteroscopy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Hospital das Clínicas de Ribeirão Preto - HCRP	Hospital das Clínicas de Ribeirão Preto - HCRP	https://ensaiosclinicos.gov.br/rg/RBR-8vd2bp	<NULL>	82 women were recruited, after being evaluated in the Contraceptive Outpatient Clinic and released for such procedure, having fulfilled all the criteria of Law 9.263 (Law on Family Planning), 1996 (article 226 of the Federal Constitution).	Minimum age of 25 years and maximum of 45 years; women with an allergic reaction to the nickel component in the devices; women who are pregnant or in the immediate puerperal period; chronic use of medications that could interfere with the pain threshold; uterine malformation; single or bilateral anterior tubal ligation or surgery; signs and or symptoms of vaginal or cervical infection;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-2ctm5q	The effect of Pilates treatment on the physical function and immunity of patients with HTLV-related nervous system disease	Data analysis completed	Intervention	2019-11-12	<NULL>	<NULL>	3182	Impact of Pilates treatment on the clinical and immunological profile of patients with Paraparesis tropical spasticity / lymphotropic virus-associated myelopathy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2ctm5q	<NULL>	The inclusion criteria selected individuals of both sexes; aged over 18 years old; with confirmed HTLV-1 infection and clinical diagnosis of HAM/TSP	Individuals who were under 18 years old or who had any disease that prevented treatment by Pilates exercises or presenting any disease that could influence the patients’ symptoms and unrelated to HAM/TSP; such as bone tuberculosis and the occurrence of pain caused by disc herniation or fibromyalgia; were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-36srkn	Effect of anesthesia associated or not with adrenaline, related to pharmacodynamics, pharmacokinetics and pharmacogenetics.	Recruiting	Intervention	2019-11-12	<NULL>	<NULL>	3183	Pharmacogenetic study and PK / PD after infiltrative application of lidocaine with or without adrenaline in saliva samples by LC MS / MS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-36srkn	<NULL>	"The participant must be in treatment at LAFFIC and should be in good general health,
with no infection and no systemic disease. To be included in the research, the participant must not be taking any medication that could alter their perception of pain, or even antidepressant, diuretic or anticoagulant medications. These data will be verified in the anamnesis form contained in the FOB / USP medical record and / or updated before scraping and evaluation of each participant&apos;s general health history."	Patient with periodontal disease; patients with systemic diseases; patients with infection at the scraping site; patients with cardiovascular, renal or liver disease; patients taking antidepressant, diuretic or anticoagulant medications; patients with a history of allergy to any local anesthetic or vasoconstrictor; pregnant and lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-6qgc6m	Influence of gene P450 (CYP2C9) on clinical efficacy and pharmacokinetics of Piroxicam after third molar surgery	Recruitment completed	Intervention	2019-11-13	<NULL>	<NULL>	3184	Influence of genotype of cytochrome P450 (CYP2C9) on clinical efficacy and pharmacokinetics of Piroxicam after lower third molar surgery	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2013-10-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-6qgc6m	<NULL>	Healthy volunteers of both genders; between 18 and 60 years; are not making use of nonsteroidal anti-inflammatory drugs in the last 7 days.	Local anesthetics allergy, history of gastrointestinal bleeding or ulcers; kidney disease; asthma; allergy or sensitivity to aspirin or any other anti-inflammatory non-steroid agent; pregnant or nursing women; patients using antidepressant; diuretic or aspirin; patients received antibiotics for 30 days prior to surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-3bjjf4	Analysis of stress and sleep hormones in the nursing team that works the day after receiving massage to control symptoms and ways to cope with stress, pain and sleep: a randomized clinical trial	Recruitment completed	Intervention	2019-11-13	<NULL>	<NULL>	3185	Analysis of cortisol and melatonin in daytime nursing workers in the management of stress, pain, sleep and occupational coping strategies after the use of massage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-05	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bjjf4	<NULL>	Women aged 20 to 45 years; sleep period performed totally in the dark; belonging to the morning shift; score of 40 or more from the List of Stress Symptoms; working time in the hospital between one and three years; return of vacation or medical leave after 30 days.	"Smoking; hypertensive; use of beta-blockers, glucocorticoids, psychotropic and anxiolytics; pregnant women;
hysterectomized; professionals with holidays marked or on medical leave during the research period; early use of the previous drugs in the collection period; up to four sessions of other integrative practices two months ago; of integrative practices (during the period of data collection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-2xc5vr	Low Intensity Laser Therapy in Skin Injury Caused by the Use of Orthopedic Cage	Recruiting	Intervention	2019-11-13	<NULL>	<NULL>	3186	Photobiomodulation in Cutaneous Lesion Caused by the Use of Circular External Fixator: Clinical Study, Placebo Controlled and Randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Clínica Dr Ayres Fernando Rodrigues	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2xc5vr	<NULL>	Participants over 18 years of age, both genders; with preserved cognition; using circular external fixator due to bone discrepancy; pseudarthrosis or bone deformity.	Participants with active neoplasms; palliative care; osteomyelitis; infected skin lesion; decompensated diabetics; or participation in another concomitant clinical trial; aged above 70 years or younger than 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-8f4s9d	Does the laser in combination with exercises improve pain and function of patients with knee osteoarthritis?	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	3187	Does the low-level laser therapy in combination with therapeutic exercises improve pain and function of patients with knee osteoarthritis? A randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de São Carlos	Departamento de Fisioterapia (DFisio) da UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-8f4s9d	<NULL>	Present OA diagnosis at least in one knee compartment (tibiofemoral and/or patellofemoral); present grade 2 or 3 in the radiographic examination of OA; present a minimum pain intensity of 4 cm in the visual analogue scale (total of 10 cm) at the most affected knee	Body mass index (BMI) greater than or equal to 35 kg/m2; physical therapy in the 3 months prior to recruitment; intra-articular therapy with steroid anti-inflammatory drugs in the knees 6 months prior to recruitment; ankle, knee or hip surgery of both limbs; and present any medical condition that could affect the participation in the study (cardiorespiratory, neurological and/or musculoskeletal diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-82szgp	Effects of eight weeks of traditional set and intra-set interval training on muscle strength and power	Recruitment completed	Intervention	2019-11-15	<NULL>	<NULL>	3188	Effects of eight weeks of traditional versus cluster set training on muscle strength and power	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-15	Universidade Federal do Rio de Janeiro - UFRJ	Universidade Federal do Rio de Janeiro - UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-82szgp	<NULL>	Be between 18 and 24 years old; be physically active; do not perform strength training at the gym or perform inconsistently for up to 6 months	Present positive PAR-Q; present osteomioarticular injury that interferes with evaluation results or training; make use of disallowed resources to increase training or evaluation performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-9zzg4d	Evaluation of dental sensitivity after bleaching using a bleaching gel with bioglass nanoparticles	Other	Intervention	2019-11-15	<NULL>	<NULL>	3189	Effect of hydrogen peroxide 35% bioglass nanoparticles-containing on tooth sensitivity for in-office bleaching: A randomized triple blind clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9zzg4d	<NULL>	Age between 18 and 30 years, regardless of gender; have a voluntary interest in undergoing aesthetic treatment for teeth whitening; agree to the Informed Consent Form (ICF); present from first to first molar, in the upper and lower arches, healthy, without caries lesion and / or restoration with extension to the buccal face of the teeth; present teeth with initial color A2 or higher, according to the Classic Vita scale; present good oral health (absence of injury or any type of alteration suggestive of pathology) and systemic; have good oral hygiene and periodontal health (absence of gingivitis and periodontitis, the latter being considered as the presence of two or more teeth with 3mm probing depth).	Patients who have already undergone teeth whitening treatment; patients with self-reported dental sensitivity (spontaneous and / or provoked); have teeth with severe color change (staining by tetracycline, fluorosis, hypoplastic; and / or traumatized; have teeth endodontically treated, among which will undergo the whitening procedure; are undergoing medical treatment or are using controlled medication; 6. Are using anti-inflammatory and / or analgesic medications, having recessions of gingival tissue and exposure of dentine tissue in the cervical region, having functional and painful symptoms of the mandibular temporomandibular joint (TMJ), having teeth with clinically visible cracks or fracture; orthodontic appliance or any type of prosthetic restoration, female patients who are pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-6y7m8z	Treatment of efforts urine losses through conventional physical therapy and Virtual Games.	Recruitment completed	Intervention	2016-06-16	<NULL>	<NULL>	3190	Protocol of treatment for mixed urinary incontinence through kinesiotherapy and virtual reality - Wii Fit Plus.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6y7m8z	<NULL>	45 and 70 years of age; no hymen intact; have  urinary incontinence in Pad Test 1 hour; unable to exercise for the muscles of the pelvic floor; their informed consent; not make use of hormone replacement therapy for three months; not have done perineoplasty; without prolapse grade III or IV; no history of epilepsy.	Not understand simple verbal commands; can not contract the pelvic floor muscles in isolation; to present vaginal or urinary tract infection; withdraw consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-9x9n75	Osteopathic treatment of head pain and nasal congestion in adult sinusitis	Recruiting	Intervention	2017-07-04	<NULL>	<NULL>	3191	Effect of using osteopathic techniques on pain and nasal congestion symptoms in adult patients with chronic rhinosinusitis: randomized and controlled clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-09	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9x9n75	<NULL>	Volunteers with clinical diagnosis of sinusitis; Nasal congestion symptom and or face pain; Both genders; non smokers; Age between 18 and 55 years	Volunteer smokers; Diagnosis of chronic diseases, cancer and skin diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-7sf399	Use of Acupuncture as a therapeutic resource for the treatment of chronic pain in patients with hemophilia.	Recruitment completed	Intervention	2019-11-18	<NULL>	<NULL>	3192	Acupuncture in Hemophilic Patients with Chronic Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-16	Faculdade de odontologia de piracicaba	universidade de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7sf399	<NULL>	Man. Age between 18 to 65 years. Moderate and Severe Hemophiliac A and B. Chronic pain.	Woman. Acute situation of hemarthrosis and muscle bleeding. acute synovitis. neoplasms. chemical or radioactive synoviorteses. joint infiltration. fracture within a period of up to 06 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-9xzsyx	Analysis of Intellectual Capabilities in People with Multiple Sclerosis in Virtual Games	Recruiting	Observational	2019-11-18	<NULL>	<NULL>	3193	Analysis of Cognitive Functions in people with Multiple Sclerosis in Virtual Activities	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-22	Universidade de São Paulo	Associação Brasileira de Esclerose Multipla	https://ensaiosclinicos.gov.br/rg/RBR-9xzsyx	<NULL>	All patients under clinical follow-up for Multiple Sclerosis will be considered eligible in the Brazilian Multiple Sclerosis Association.	Patients with visual impairment; with motor deficits that prevent them from performing the task; with presence of fatigue; with deformity or muscle weakness in the upper limbs; who have had an outbreak in the last month; performing surgery; chemical neuromuscular blockage in the upper limbs in the last six months prior to study participation; who are unable to perform the task in a single attempt with the verbal instructions and demonstrations provided	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-848sdg	Effects of Diet to Combat Hypertension, Improve Obesity and Intestinal Bacteria in High Blood Pressure Patients	Recruitment completed	Observational	2019-11-18	<NULL>	<NULL>	3194	"Effects of the intervention of the method to combat hypertension through diet
(DASH) on cardiovascular risk factors, endothelial function and intestinal microbiota
in patients with cardiovascular disease"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-848sdg	<NULL>	Elderly female and male patients with body mass index (BMI) above 18.5 Kg / m² for both sexes, older than 60 years up to 85 and diagnosed with systemic arterial hypertension according to the study will be included in the study. the Brazilian Society of Cardiology criteria. The fit patients who were invited to participate in the research by reading and signing the Informed Consent Form (ICF). Patients will be followed for 6 months in monthly outpatient consultations, R24h were performed in all consultations in both groups. For GI patients, recipes adapted to the DASH diet model will be performed. Laboratory tests, body composition analysis and food frequency questionnaire will be performed at the beginning and end of the research. Patients will be followed up via phone contact, email or text messages weekly.	The study considered patients ineligible for prebiotics, probiotics, symbiotics supplementation in the last 3 months or receiving antibiotic therapy. Patients with glomerular filtration rate &lt;60 ml / min, presence of pacemaker, presence of infectious or autoimmune disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-74j2z5	Immunological and clinical evaluation of supporting dental tissues using local simvastatin a controlled clinical trial	Recruiting	Intervention	2019-11-18	<NULL>	<NULL>	3195	Immunological and clinical evaluation of local use of Simvastatin in patients with Chronic Periodontitis a randomized double masked clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-27	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-74j2z5	<NULL>	Age between 30 years and 70 years. At least 15 teeth in the mouth excluding third molars. Diagnosis of generalized chronic periodontitis according to Armitage et al 1999, which provides for the collection of clinical, radiographic findings and verification of medical and dental history. As clinical periodontal findings, patients should have at least 30% of the periodontal sites with PCS and NCI &gt; 4mm and bleeding on probing. In addition, they should have radiographic evidence of bone loss around the viable teeth. D) Go to scheduled return visits, and should be able to maintain good biofilm control at reevaluations (O&apos;Leary plaque index &lt;30%)	Patients with medical history linked to systemic diseases. Hypersensitivity to any type of statin. Have used any type of antibiotic for at least 3 months prior to the study. Had peridontal treatment 6 months before the beginning of the trial. Being pregnant and / or breastfeeding. Alcohol users, smokers and ex-smokers (5 years at least). Patients with cancer and / or undergoing chemotherapeutic / radiotherapeutic treatment. Patients diagnosed with aggressive periodontitis. Also excluded from the analyzes dental elements that have pathogenic endodontic ivolvement, third molars and dental implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-9r2mqz	Validation study of a new dental biofilm evaluation protocol in children with mixed dentition from 7 to 12 years old	Recruiting	Intervention	2019-11-18	<NULL>	<NULL>	3196	Validation of the reliability of the optical fluorescence method for the diagnosis of dental biofilm after application of antimicrobial photodynamic therapy in young permanent molars: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9r2mqz	<NULL>	There will be 40 children aged 7 to 12 years, all patients from the Pediatric Dentistry Outpatient Clinic of the University of Nove de Julho; The evaluated and treated dentition will be the healthy dentition, in molars, following the IHOS evaluation	The exclusion criteria of this protocol will be children who are taking interceptive orthodontic appliances; Children with a recent history of oral and or nasal surgery; Children who present a feverish state in the act of consultation and collection; Children undergoing viral and or infectious throat, nose and oral mucosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-4q8rgp	Effect to use occlusal bite on the progression of dental abrasion	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3197	Effect of occlusal plaque on the progression of abfration lesions	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4q8rgp	<NULL>	Two visually perceptible lesions on the buccal surface of the teeth; visually perceptible and without indication of restoration; with or without TMD and / or the presence of excessive occlusal wear due to teeth clenching and / or grinding.	Non-carious cervical lesions in patients with GERD; using continuous medication that could interfere with salivary flow and promote dental erosion; those diagnosed with less than 2 abfraction lesions; very extensive lesions and teeth with gyroversion; or without antagonist and adjacent teeth and with idiopathic erosion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-3c7rt3	Effects of different types of Aerobic Exercise and Weight Training protocols combined on adult health indicators with Obesity	Not yet recruiting	Intervention	2018-02-07	<NULL>	<NULL>	3198	Effects of different Concurrent Exercise Training protocols in health indicators of Obese adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-26	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3c7rt3	<NULL>	"To be voluntary;
Have BMI greater than or equal to 30kg / m²;
Having a minimum and maximum age of 20 and 50,
respectively;
To present medical certificate releasing him to practice physical exercises;
To present an electrocardiogram performed in the last year;
Not being engaged in physical exercise programs since the last 3 months;
Do not be a smoker;
Do not drink alcohol in excess (5 doses at a time)."	"Have the BMI greater than 39.9kg / m2;
Have a diagnostic of some other chronic disease;
Have any physical, visual, auditory, motor or cognitive deficiency;
Use of any medication for the control and / or treatment of obesity;
Have performed some surgical procedure aiming the weight reduction."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-2gv5c2	Effects of yoga on different health markers	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3199	Effects of yoga on heart rate variability, electroencephalogram, quality of life, salivary cortisol and functional neuroimaging by magnetic resonance in healthy adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2gv5c2	<NULL>	Healthy volunteers; both genders; age between 18 and 40 years; no experience with Bhastrika Pranayama	Diagnosis of heart problems; chronic rhinitis; frequent use of aspiration bronchodilator; regular use of beta blocker or stimulant and any drug that interferes with cardiac modulation; diagnosis of neurological or psychiatric disorders; pregnancy; metallic implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-875zsw	The Effect of different electrotherapy modalities on pain, funtion and life quality maintenance on individuals with knee osteoarthritis (OA)	Recruiting	Intervention	2017-11-24	<NULL>	<NULL>	3200	The Effect Of Interferential Current (IC), Transcutaneous Electrical Nerve Stimulation (TENS), Australian Current (Aussie) On Pain, Function And Quality Of Life Maintenance On Individuals With Knee Osteoarthritis (OA)- Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Faculdade de Educação Física - UnB	Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-875zsw	<NULL>	Men and women over 60 years of age who do not exercise regularly - frequency less than 3 times a week (Blackburn et al, 2006), with a diagnosis of knee OA; Signs of OA in at least one of the knee joint compartments (tibiofemoral and / or patellofemoral joint) (Brenner et al., 2003; Hortobágyi et al., 2004); Grade 2 or 3 on radiographic examination, according to Kellgren &amp; Lawrence criteria, and present a minimum score of 4 cm in VAS confirmed by a medical professional; Not having undergone physiotherapeutic treatment in the 3 months prior to the research project; No infiltration with corticosteroid in the knee (previous 6 months); Bennell et al., 2003); In addition, a lack of medical restriction that impossibilitate to participate in the proposed evaluations (cardiorespiratory, neurological and / or musculoskeletal changes) and previous knee or hip surgeries.	Obtain a score of less than 18 points in the Mini- Mental State Examination in the case of illiterate elders and less than 24 for the school-aged elderly (Lourenço; Veras, 2006); Get scores greater than 10 on the EDG-30 Geriatric Depression Scale (Almeida and Almeida, 1999; Stoppe Júnior et al., 1994); Have a total absence of more than 25% of the total number of sessions;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-3vt4bs	Effect of exercise training in inflammatory process control in patients with chronic obstructive pulmonary disease	Recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3201	Effect of exercise training in inflammatory process control, mediated by Th17/Treg response in patients with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-19	Hospital das Clínicas da Faculdade de Medicina da USP	Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-3vt4bs	<NULL>	Patients with chronic obstructive pulmonary disease; aged over 50 years; non smokers, of both genders; clinically stable; who have not participated in regular physical training in the last 6 months	Patients with other chronic lung disease; or with rheumatoid arthritis; multiple sclerosis; decompensated diabetes; autoimmune hepatitis; chronic cardiovascular disease; malignant tumor; or with acquired immunodeficiency syndrome - AIDS; use of immunosuppressive drugs; presence of musculoskeletal disorders that make it impossible to perform physical exercise; continuous use of oxygen therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2d4vvv	Efficacy of conventional and BoNTA treatment in patients with Temporomandibular (TMD) disorder	Data analysis completed	Intervention	2019-11-19	<NULL>	<NULL>	3202	Efficacy of conventional and BoNTA treatment in patients with Temporomandibular (TMD) chronic pain	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-04	Faculdade de Odontologia de Piracicaba, Universidade estadual de Campinas	Faculdade de Odontologia de Piracicaba, Universidade estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2d4vvv	<NULL>	Female volunteers; aged 18-45 years; with muscular TMD; with pain for more than 3 months; using contraception; with all teeth; class I of Angle; having stable occlusion.	Volunteers with trauma in the face and TMJ; with bruxism; wearing dentures; on orthodontic treatment; using anti-inflammatory medication, analgesic and / or muscle relaxant; with coagulopathy; with neuralgia; with arthritis; osteoarthritis; diabetes; neurological disorders; primary headache; fibromialgy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-4gn9rv	Pelvic physiotherapy in the transgender population	Recruitment completed	Intervention	2019-11-19	<NULL>	<NULL>	3203	Performance of pelvic physiotherapy in the transgender population	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4gn9rv	<NULL>	For Transgender Women:Transsexual women who underwent sex reassignment surgery; individuals 18 to 60 years old. For Transsexual Men: transsexual men; over 18 years old; in use hormone therapy; having or not performed transsexualizing surgeries such as Mastectomy of Masculinization or Total Hysterectomy	Transsexual women who did not undergo sex reassignment surgery; Transsexual women reassigned in trial period; men not on hormone therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-6f2npm	The epi-no in the preparation for vaginal delivery	Recruiting	Observational	2019-11-19	<NULL>	<NULL>	3204	Implications of using epi in preparation for vaginal delivery	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6f2npm	<NULL>	"Ge: primiparous postpartum women; 18 to 40 years old; who made use of Epi-No during pregnancy for normal delivery
Gc: primiparous postpartum women; 18 to 40 years old; who did not use Epi-No during pregnancy for normal delivery"	Women who have some cognitive deficit; risk pregnancy; multiple gestation; other type of delivery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-6jccqs	Effects of Physical Training on elderly Hypertensive Patients	Recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3205	Effects of Periodized Concurrent Physical Training on hemodynamic and biochemical variables of elderly Hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Facudade Estácio de Sergipe - FASE	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-6jccqs	<NULL>	Elderly women; aged 60 to 80; hypertensive stage I and II; sedentary; no target organ damage	Volunteer smokers; history of alcohol or drug abuse; mental disorder; having systolic and diastolic blood pressure above 180 mmHg and 110 mmHg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2jq26n	Effects of electric current treatment on diabetic foot healing	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3206	Effects of therapeutic resources on vascularization and healing of diabetic foot	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jq26n	<NULL>	Patients of both sexes aged 40 years and over; with type II diabetes mellitus who have vascular and / or neurological complications in the lower limb due to diabetes mellitus.	Patients with diabetes who have lower limb amputation; some psychiatric disorder that may not understand and opt for their participation in the study; active infectious processes; decompensated hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2hth8p	Motion capture assessment in upper limb neurofunctional rehabilitation in patients with chronic stroke	Recruitment completed	Intervention	2019-11-19	<NULL>	<NULL>	3207	Kinematic evaluation in upper limb neurofunctional rehabilitation in patients with chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual de Maringa	Universidade Estadual de Maringa	https://ensaiosclinicos.gov.br/rg/RBR-2hth8p	<NULL>	Inclusion criteria for research patients will be: (I) clinical diagnosis of stroke; (II) be between 30 and 70 years old; (III) agree and sign the voluntary participation consent form; (IV) time of injury greater than six months; (V) sequelae of neuromotor dysfunction resulting from stroke and (VI) earn over 18 Mini-Mental Test points.	Exclusion criteria for patients under study will be: (I) diagnosis of neurological or cardiovascular instability, exercise contraindication (uncontrolled hypertension); (II) severe neuropsychological insufficiency (global aphasia, severe attention deficit or neglect), the patient should be able to follow instructions, understand the tasks performed, minimize differences in the final outcome due to lack of understanding of the tasks requested and performed, (III) impairment of the upper limb that prevents the performance of tasks and (IV) 18 points or less in the Mini-Mental Test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-26kn3b	Effects of exercise on a stationary bicycle combined with training of the respiratory muscles in individuals with Parkinson&apos;s disease.	Recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3208	Comparison between training of upper limb respiratory and peripheral resistance on the respiratory function of patients with Parkinson&apos;s disease: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-14	Instituto de Ciências da Saúde da Universidade Federal da Bahia	Clínica Escola de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-26kn3b	<NULL>	Being on regular medication for Parkinson&apos;s disease; being on the medication &quot;on&quot; period; have age greater than or equal to 50 and less than or equal to 80 years; present stage 2, 2.5 or 3 according to the Hoehn and modified Yahr classification.	To present neurodegenerative diseases excluding Parkinson&apos;s disease; osteomioarticular diseases that make it impossible to practice physical activity; chronic non-controlled diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular diseases (acute heart failure, recent myocardial infarction, unstable angina and uncontrolled arrhythmias); use of alcohol and other toxic substances; practicing or practicing a physical exercise program in the last 6 months; or participate in or participate in regular resistance training (2-3 times per week) in the previous 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-8rgwcq	Resistive Training in Coronariopathy with Diastolic Dysfunction	Not yet recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3209	Progressive Resistive Training combined with Inspiratory Muscle Training in Coronariopathy with Diastolic Dysfunction: Clinico-functional cardiovascular outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-28	Hospital Universitário Maria Rosa Pedrossian	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8rgwcq	<NULL>	Patients of both sexes; Age between 35 and 75 years old; Patients with chronic coronary artery disease by clinical and angiographic criteria, in different degrees of diastolic dysfunction by echocardiographic criteria; Patients who are stable for more than 30 days of symptoms, in regular use of prescription drugs; Patients with HFPEF (LVEF higher than 50%) or HFREF (Ejection Fraction between 30% and 50%);Assessed patients should be able to perform transthoracic doppler echocardiography, inspiratory muscle assessment, peripheral vascular doppler, treadmill exercise cardiopulmonary exercise testing, and to respond to the Minnesota quality of life questionnaire voluntarily before and after the experimental intervention	"HF patients and EF lower than 30%; HF patients and EF higher than 30% in Functional Class IV; Recent myocardial infarction (less than 30 days), unstable angina (more than 30 days) or sustained complex ventricular arrhythmia; Severe valvulopathies with surgical indication; Uncontrolled SAH: systolic BP higher than  190 mmHg  or diastolic BP higher than 120 mmHg;
Inability to exercise on a treadmill due to severe neuromuscular, neurological, orthopedic or psychological limitation; Patients without echocardiographic criteria of diastolic dysfunction by either pulsed or tissue Doppler; Patients with nonobstructive coronary insufficiency or nonatherosclerotic coronary heart disease"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-5y4t9t	This study aimed to compare photobiomodulation and the use of non-steroidal anti-inflammatory drugs after surgical removal of lower lip lesions with the high intensity diode laser.	Recruitment completed	Intervention	2019-11-21	<NULL>	<NULL>	3210	Comparative analysis of the use of non-steroidal Photobiomodulation and Anti-inflammatory after surgical removal of Lower Lip Lesions with High Power Diode Laser	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5y4t9t	<NULL>	The study included patients who sought care and were referred to the Interdisciplinary League for Combating Oral Cancer (LINCCO) and agreed to participate. Subjects will be studied, regardless of gender and age, with clinical diagnosis of lower lip injuries. For the inclusion of individuals, lesions should present a clinical aspect of mucocele.	Individuals on continuous use of analgesic or anti-inflammatory medication, immunosuppressed or immunosuppressed were excluded from this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-7gvrmm	Effects of Occlusion Exercise on blood pressure in patients with Knee Arthrosis	Recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3211	Effects of a single session of Blood Flow Restriction Training on hemodynamic, autonomic and vascular responses in individuals with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)	Faculdade de Medicina, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gvrmm	<NULL>	Post-menopausal women between 40-85 years, with knee osteoarthritis according to the criteria proposed by the American College of Rheumatology. The participants should present grade II or III of severity of the osteoarthritis according to Kellgren &amp; Lawrence and pain rated between 2 and 8 in the visual analogue scale.	The participants will be excluded if they present: cardiovascular, pulmonary, metabolic or any other disease that could preclude the procedures; systolic blood pressure greater than 160/105 mmHg; ischemia or arrhythmia during the exercise test; lower limb venous insufficiency; previous thrombosis and/or phlebitis in lower limbs; musculoskeletal impairment that preclude the performance of physical activity; body mass index greater than 35 kg/m2; under use of medications affecting the autonomic nervous system (e.g., beta blockers, and non-dihydropyridine calcium channel blocker); under use of anticoagulants; under glucocorticoid infiltration in the last 3 months; or under use of any glucorticoid in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-9hg244	Management of thoracotosmy tube with lung ultrasound.	Recruitment completed	Intervention	2019-11-22	<NULL>	<NULL>	3212	Management of thoracotosmy tube with lung ultrasound	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Alexandre Zanchenko Fonseca	Hospital Geral do Grajau	https://ensaiosclinicos.gov.br/rg/RBR-9hg244	<NULL>	Patients submitted to pleural drainage due to pneuothorax and hemothorax	Pulmonary disease; subcutaneous emphysema	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-8xjjqy	Effect of Strength Training on Neuromuscular Adaptations in Older Women and Youth	Recruitment completed	Intervention	2019-11-22	<NULL>	<NULL>	3213	The Trainability of Neuromuscular Adaptations of Older Women and Youth	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-08	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-8xjjqy	<NULL>	"Seniors aged 60 to 82 years;
Elderly women who were only practicing the Prev Quedas project gymnastics;
Elderly women who independently maintained their daily activities, verified through Baecke&apos;s Modified Questionnaire;
Only those who presented medical examination authorizing the practice of strength exercises participated;
Elderly women who obtained a completed application form in the Prev Quedas project."	"Elderly women with clinical conditions that represented an impediment to performing the proposed exercises, or associated with increased health risks (for example: blindness, limb amputations, diseases of the following types: degenerative, osteomioarticular, metabolic, renal, severe heart disease: angina, coronary heart disease, uncontrolled hypertension, arrhythmias, valvular disease, and heart failure; difficulty in maintaining the standing position or use of orthosis to aid gait; and cancer);
Elderly women with spinal problems with medical restriction;
Those who underwent surgery and / or hospitalization in the last 12 months;
Older women with low educational level;
Elderly women who used 5 (five) or more medications;
Those who participated in a bodybuilding program in the last 12 months;
Older women with a history of falling in the last 12 months;
Elderly women with low cognitive ability verified through the Mini Mental State Examination;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-65cxtr	Effect of Coffee on the vascular reactivity of Overweight and Obese individuals	Recruitment completed	Intervention	2019-04-08	<NULL>	<NULL>	3214	Acute effect of Coffee in the Endothelial Function of Overweight and Obesity individuals: A double-blind, randomized, cross-over clinical trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-28	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-65cxtr	<NULL>	Individuals older than or equal to 25 years and less than 60 years; both sexes; low risk or intermediate cardiovascular risk characterized by the overall risk score; with overweight and obesity grade I according to the classification of the World Health Organization.	Individuals with high and very high cardiovascular risk, according to the Update of the Brazilian Dyslipidemias Directive and Prevention of Atherosclerosis; not have performed a lipid profile test in the last year; inability to ingest caffeine; infectious diseases active or treated in the last 30 days; neurological disease; type diabetes mellitus; familial dyslipidemia; smokers; hospitalization in the last 2 months; Renal insufficiency; hepatical cirrhosis; chronic obstructive pulmonary disease; coronary artery disease; cardiac insufficiency; atrial fibrillation; severe peripheral arterial insufficiency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-7fhgkk	The effects of Dance and Pilates in people with Cerebral Palsy	Recruitment completed	Intervention	2019-01-16	<NULL>	<NULL>	3215	Dance and Pilates in Cerebral Palsy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7fhgkk	<NULL>	Individuals with cerebral palsy; age range between fifteen and twenty nine years old; presence of muscular hypertonicity determined to passive motion test; which do not any physical exercise or therapeutic treatment parallel to the development of protocols research; do not present cardiopathies; do not present neoplasies.	Exclusion criteria will be those with cognitive or psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-45kv2n	Comparison of hydrotherapy anddry land exercise associated with lasertherapy on pain relief, stretching and daily activities in elderly patients with knee osteoarthritis	Recruitment completed	Intervention	2016-03-02	<NULL>	<NULL>	3216	Comparison of physiotherapy aquatic and dry land exercise associated with low level laser therapy in perception of pain, flexibility and life daily activities in elderly with knee osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-45kv2n	<NULL>	Volunteers knee osteoarthritis; both genders; age between 60 and 80 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-74rqnz	The effect of a wrist orthosis night using in the pain and paresthesia in persons with carpal tunnel syndrome	Recruitment completed	Intervention	2016-03-15	<NULL>	<NULL>	3217	Randomized clinical trial of nocturnal wrist orthosis therapy in the function and symptoms of carpal tunnel syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-04	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-74rqnz	<NULL>	Medical and kinetic-functional diagnosis of carpal tunnel syndrome; test electromyography to report to carpal tunnel syndrome in grade I or II; absence of musculoskeletal disorders in elbow and shoulder joints; pain and symptoms present for at least six months; active range of motion of shoulder flexion and abduction greater than or equal 120°; active range of motion of elbow flexion of 100° and wrist extension of 30°; positivity for Tinel and Phalen tests.	History of trauma or previous surgery in the upper extremities or spine; subluxation of acromioclavicular joint and/or glenohumeral joint; osteoarthritis or tendinopathy in the shoulder, elbow, wrist and hand; rheumatic, degenerative or neurological disease; partial or complete rotator cuff tear or other complex muscles of the shoulder joint; being in physical therapy or using orthosis for less than three months prior to research; positivity for lateral and medial epicondylitis tests;positivity in at least two of the following tests: Neer, Hawkins, painful arc between 60 ° and 120°, Jobe, infraspinatus test, apprehension test, replacement, sulcus sign, Rowe and Speed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-46yxnr	Suplementation of nutrients like zinc and coenzyme Q10 in peoples with Down Syndrome	Recruiting	Intervention	2019-11-25	<NULL>	<NULL>	3218	Suplementation of Zinc and Coenzyme Q10 in individuals with Down Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal do Rio Grande do Norte - UFRN	FarmaFórmula Cidade Alta	https://ensaiosclinicos.gov.br/rg/RBR-46yxnr	<NULL>	Individuals who agree to participate in the research; as well as those responsible; have ages between 5 and 9 years; are present at the institution during the evaluation period	Participants with antioxidant therapy; diabetics; congenital heart disease, nephropathy; individuals with systemic inflammation and / or severe disease that makes it impossible to perform the study; smoking individuals; those who make use of alcoholic beverages; individuals who are in some type of pharmacological therapy, including vitamins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2v5gvd	Physiotherapy techniques and preparation for normal delivery: A protocol accomplished at the northeast of Pará	Recruitment completed	Intervention	2019-11-25	<NULL>	<NULL>	3219	Physiotherapy techniques and preparation for normal delivery: A protocol at a pre natal reference care at the region of the Caetes, northeast of Pará	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-20	Núcleo de Medicina Tropical/Universidade Federal do Pará	Núcleo de Medicina Tropical/Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2v5gvd	<NULL>	Primigravida of normal risk between 18 and 35 years old that want to have a normal delivery and that are in regular prenatal follow-up.	Hight risk pregnant womem, pregnant womem that can not do pelvic physiotherapy or regular exercises, that present abortion risk or risk for having a premature delivery, that have had abortion or pelvic surgery and that present cognitive disturbance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-9cbp8s	Effects of exercise training with power control in muscle strength, cholesterol and body fat postmenopausal women	Recruitment completed	Intervention	2016-04-04	<NULL>	<NULL>	3220	Effects of physical training and diet control on muscle strength, cardiorespiratory fitness, biochemical variables and body composition in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9cbp8s	<NULL>	Female volunteers; aged between 50 and 65 years; present in the menopausal period without menstruation for 1 year or more; possess a medical certificate to perform the tests required and participate in the training program.	Present physical limitations or any health problems that prevent the implementation of the evaluation or bodily practices; accumulate three consecutive unexcused absences or 4 unexcused absences during the month of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9fqwyw	Therapy for the treatment of children with inattention and hyperactivity	Recruitment completed	Intervention	2016-03-18	<NULL>	<NULL>	3221	Cognitive behavioral therapy in the treatment of children with attention-deficit hyperactivity disorder (ADHD)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-07-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fqwyw	<NULL>	"Aged 7 to 14 years; 
Indicative of ADHD as a primary disorder; 
No indications of developmental delays.
Total sample is 40 participants"	"Prematurity;
Established diagnosis of other conditions (intellectual déficit; epilepsy; genetic syndromes; HIV; hydrocephalus; brain lesions)
Current use of other medications except methylphenidate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7t6rg2	Pelvic organ prolapse: comparison of two surgical techniques for the treatment of uterine prolapse	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	3222	"Comparison of two surgical techniques for treatment of uterine prolapse: sacrospinous vault fixation and use anterior mesh with 
colpopromontofixation"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-7t6rg2	<NULL>	Women with stage uterine prolapse 3 and 4. Women menopausal between 55-75 years. Are only included postmenopausal women because the genital prolapse is a condition more prevalent in this age group and has developed differently when it occurs in premenopausal women. To homogenize the group, we will select only postmenopausal women. Sample size target will be 90 women with uterine prolapse stage three and four.	Women who do not wish to participate in the study. Women with cognitive impairment and illiterate and unable to understand the questionnaires. Women who have or have had gynecological cancer. Women with pelvic floor surgery antecedent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-26q4z9	Effects of exercises with action observation and aquatic physical therapy in arm recovery after stroke	Recruitment completed	Intervention	2016-03-23	<NULL>	<NULL>	3223	Comparative study between action observation training and hydrotherapy in upper limb recovery after stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Mato Grosso do sul	Universidade Federal de Mato Grosso do sul	https://ensaiosclinicos.gov.br/rg/RBR-26q4z9	<NULL>	Sample consists of 60 adult participants with a minimum age of 40 years and maximum age of80 years. Inclusion criteria: diagnosis of a single episode of ischemic or hemorrhagic stroke occurred between 3 months and 2 years in good health condition; with brachial- facial hemiparesis; with mild to moderate and independent walking even under use of any assistive device for ambulation	Exclusion criteria: more than one episode of stroke; with evidence of lesions in the cerebellum; brainstem or bilateral hemispheric injury. Aphasia; clinically unstable and comorbidities that interfere with motor function and severe spasticity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-6268zz	Effect of root planning in microbiological, White blood cells, immunoglobulins and pro and anti inflamatory cytokines dosage in blood and saliva from periodontitis and type 2 diabet persons	Recruitment completed	Intervention	2016-03-05	<NULL>	<NULL>	3224	Effect of mechanical periodontal therapy in microbiological, imunocelular, immunoglobulins and pro and anti inflamatory cytokines dosage in periferal blood and saliva from type 2 diabet persons	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-20	Universidade de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6268zz	<NULL>	Minimum of 15 teeth; least 30 percent of the sites with periodontal probing depth greater than or equal to 4 mm; at least two teeth with greater insertion loss than 3 mm; Age greater than or equal to 30 years. The control group will consist of individuals aged greater than or equal to 30 years; systemically healthy; Clinical and radiographic periodontal health; Minimum 20 teeth with less clinical probing depth or equal to 3 mm; lower insertion level at 3 mm; less than 10% of sites with bleeding on probing	Periodontal treatment in the last six months; Continued use of medications such as antibiotics, immunomodulators or anti-inflammatory drugs in the last three months; Systemic diseases that interfere with periodontal condition, except for diabetes for the test group (HIV, immune disorders, morbid obesity (BMI 40 kg / m2) or underweight (BMI less malnourished 18.5 kg / m2), etc.) ; Pregnant or lactating; smoking; Under age 30; Indigenous groups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7kzh4p	Cohort study of children born in Campinas and Paulínia-SP	Recruitment completed	Observational	2016-04-07	<NULL>	<NULL>	3225	Cohort study of children born in Campinas and Paulínia-SP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Centro Infantil Boldrini	Instituto Ronald McDonalds	https://ensaiosclinicos.gov.br/rg/RBR-7kzh4p	<NULL>	"It will be eligible for this study pregnant women in the first trimester of pregnancy, user  of one of the 63 Public  Health Center Services /  Basic Health Unit/SUS located in Campinas City, São Paulo, Brazil.
Additionally, it will be included pregnant women in the first trimester of pregnancy, user of one service among  9 Public Health Centers /  Basic Health UNIT / SUS located in Paulínia City , São Paulo, Brazil"	"Pregnant women in late pregnancy, who did not answered the epidemiological questionnaire and did not participate with the peripheral blood collection.
Pregnant women who do not perform prenatal care in the Public Basic Health Units / SUS located in the Cities of Campinas and Paulinia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7kcr2p	Evaluation of muscle strength, exercise capacity, heart rate and blood inflammatory of patients with chronic obstructive  pulmonary disease submited to physical exercises	Recruitment completed	Intervention	2016-03-31	<NULL>	<NULL>	3226	Functional and biological evaluation of subjects with chronic obstructive pulmonary disease submited to protocols of physical training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-29	Faculdade de Ciências e Tecnologia - Unesp	Faculdade de Ciências e Tecnologia - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-7kcr2p	<NULL>	Patients must have a diagnosis of chronic obstructive pulmonary disease; both genders; tifennau index less than 70 percent; be aged between 45 and 70 years; being clinically stable.	Cardiac comorbidities and musculoskeletal disorders; exacerbation within one month of the initial evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-86mhm2	Dexamethasone effect on the duration of interescalenic brachial plexus block guided by ultrasound for videoarthroscopic shoulder surgery	Recruitment completed	Intervention	2016-04-05	<NULL>	<NULL>	3227	Dexamethasone effect on the duration of interescalenic brachial plexus block guided by ultrasound for videoarthroscopic shoulder surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-12-03	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-86mhm2	<NULL>	patients submitted to videoarthroscopy shoulder surgery	patients under 18 years old, previous history of allergy to any used medication in the procedure and diabetes (because of potential hyperglicemia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7hrnhg	Effect of body weight-based Strength Training in hypertensive elderly	Recruitment completed	Intervention	2019-11-25	<NULL>	<NULL>	3228	Acute effect of a strength-based Alternative Training session on Blood Pressure in hypertensive elderly: a randomized crossover trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7hrnhg	<NULL>	Regularly participate in the PROCOR extension program for less than six months; have medical authorization for physical exercise; be 60 years old or older; have a diagnosis of hypertension or have controlled blood pressure with medication.	Osteomioarticular limitations for the execution of strength exercises; episode of acute myocardial infarction or have had cardiac surgery for less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-5xtfj9	Short-term effects of cupping as pain and movement therapy and lumbar spine	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	3229	Immediate effects of cupping on pain and range of motion of the lumbar spine	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5xtfj9	<NULL>	Healthy adult volunteers; both genders; age between 18 and 60; weight within the limit of variation of 15% of that considered normal for men and women, taking into account the height and physical structure.	Volunteers with a history of alcohol or drug abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; with lesions of the central nervous system, deformities established in the spine, previous lesion in the spine, inflammatory processes in the evaluated segment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-2vd6f2	Effects of swimming pool physical activities on the breathing of people with Parkinson&apos;s Disease	Recruitment completed	Intervention	2019-11-25	<NULL>	<NULL>	3230	Parkinson&apos;s Disease and Physical Therapy: Repercussion analysis of intervention programs with Terrestrial and Aquatic Physical Activities - Fisiopark	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2vd6f2	<NULL>	The inclusion criteria will be both genders; with clinical diagnosis of idiopathic PD within the stages 1 to 4 on the Hoehn and Yahr scale gravity; obtain the clinical certificate for aquatic physical activity and to attend heated swimming pool.	The exclusion criteria will be: not to present independent gait, related or not to PD; another disease that could interfere with physical assessments, such as changes in the balance of vestibular origin; visual or auditory sensory deficit that impedes accompanying verbal and visual instructions; any respiratory clinic or cardiovascular disease; history of pulmonary surgery; recent respiratory tract infection; do not agree with the consent term; relatives contraindication to frequent heated pool, such as fever, incontinence, severe blood pressure alteration, open wound; absence of more than 10% of the intervention; change in L-dopa-based drug intake parameters during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7wv259	Fixed regimen analgesic use compared with regimen if needed for pain after gum surgery: a randomized controlled trial	Data analysis completed	Intervention	2019-11-25	<NULL>	<NULL>	3231	Pain and analgesic consumption after surgical periodontal treatment	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2016-05-04	Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-7wv259	<NULL>	Adult patients; Patients of both sexes; Patients in need of periodontal surgery with total flap to restore supracrystal insertion tissues.	Patients who use systemic analgesics; patients who use systemic antimicrobial, patients who use systemic anti-inflammatory drugs; patients who use systemic muscle relaxants; patients on systemic anxiolytic or antidepressant use; patients with previous chronic or acute pain, related or not to the oral cavity; patients who have difficulty understanding instructions (cognitive changes), impairing the application of the scales proposed by the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-6jqp52	Characterizantion of food habits in women with Facial pain	Recruiting	Observational	2019-11-27	<NULL>	<NULL>	3232	Characterizantion of food habits in women with Temporomandibular joint disorders (rdc/tmd)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6jqp52	<NULL>	"The sample will be composed of women aged between 18 and 55 years old; who have no loss of more than five dental elements;
maladaptive prostheses; moderate to severe periodontal disease; dental or intraoral or extraoral lesions that may compromise the function
chewing. Will also be included in the sample women with orofacial pain; but can not have other painful disorders
chronic diseases; food intolerances and other systemic conditions that may lead to food restriction."	"Participants with cognitive impairment that precludes their participation in the study; as well as those who do not accept to participate
or leave after inclusion, will be deleted."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-8fwwj6	Short-term effects of physiotherapy techniques (myofascial release and proprioceptive neuromuscular facilitation), the movement and flexibility of posterior thigh, power and balance of amateur soccer players	Data analysis completed	Intervention	2019-08-28	<NULL>	<NULL>	3233	mmediate effects of myofascial release compared to proprioceptive neuromuscular facilitation in balance and power, range of motion, and flexibility of knee flexors of amateur soccer players	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8fwwj6	<NULL>	Healthy adult volunteers; both genders; age between 18 and 35 years; weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	Volunteers with a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; with lesions of the central nervous system, established deformities of lower limbs; previous hamstring muscle injury in the assessed limb; inflammatory processes established in the segment. Be performing physiotherapeutic treatment in progress; in concomitant participation in competitions and; with flexibility that exceeds the limits of the evaluation apparatus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9ypz5m	Performance on computer tasks in people after stroke	Recruiting	Intervention	2019-11-28	<NULL>	<NULL>	3234	Performance transfer between real and virtual environment in post stroke people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-04	Escola de Artes, Ciências e Humanidades-EACH/USP	Escola de Artes, Ciências e Humanidades-EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9ypz5m	<NULL>	Both genders; Present sequelae of stroke with motor conditions to perform the task on the computer with the paretic upper limb; cognitive task comprehension and visual conditions; authorization of individuals with due signature of the free and informed consent form	People who have difficulty playing computer games; difficulty of comprehension; visual impairment; difficulty interacting with technology; those who have weakness or fatigue during the task	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7jp5mr	Forms of communication of sexual pairs of people with sexually transmitted diseases	Recruitment completed	Intervention	2019-11-29	<NULL>	<NULL>	3235	Strategies for notifying sexual partners of people with sexually transmitted infections	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7jp5mr	<NULL>	The indexing criteria for patients were: mean age equal to or greater than 18 years, regardless of sex; serological diagnosis of STIs, hepatitis B and C and / or association associated with STI (genital ulcer, urethral discharge, genital warts); have been diagnosed during care performed at the health unit; sex dating (s) to be notified, regardless of the affective-sexual bond; express a desire to communicate with their partners.	Exclusion considerations: patient-indexes who do not agree with their adherence data or are not entitled to receive physicians within one month after diagnosis of STI; the usual before diagnosis has been used; women diagnosed with vaginal discharge syndrome due to the possibility of alterations due to other causes not associated with STIs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-8sv2kp	Study on the use of Cefixime for the treatment of syphilis in Brazil	Not yet recruiting	Intervention	2019-04-26	<NULL>	<NULL>	3236	Trial evaluating the clinical efficacy of cefixime for treatment of early syphilis in non-pregnant women	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-8sv2kp	210	"Female, 18 years of age or older; non-pregnant; able to provide informed consent; test positive for syphilis with a positive TPPA and an RPR titer equal to or greater than 1:8; non-cephalosporin allergic; non-penicillin allergic; agree to be called once a day by study staff to be reminded to take study drug; able to swallow pills; willing to attend follow-up visits at 3, 6, and 9 months after completion of the study treatment; willing to take oral contraceptive or use condom to prevent pregnancy during the
study period; HIV negative"	Female under 18 years of age; HIV positive; pregnancy test positive or clinical pregnancy; prior history of syphilis or syphilis treatment within 6 months of study screening; allergy to penicillin or cephalosporins (including allergy to cefixime); in the judgment of the interviewer, has a medical condition or other factor that might affect their ability to follow the protocol; previous enrollment in the study; presenting a condition that would not allow reliable informed consent (alcohol abuse or substance misuse); lacking mental capacity to give informed consent to participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-8h4dty	Impact of a physical exercise program on the health of people with epilepsy: clinical trials	Recruitment completed	Intervention	2019-11-29	<NULL>	<NULL>	3237	"Effects of physical exercise on health outcomes and epileptic seizure control
of people with epilepsy: a randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-19	Escola Superior de Educação Física da Universidade Federal de Pelotas	Instituto Federal de Educação, Ciência e Tecnologia Sul-riograndense	https://ensaiosclinicos.gov.br/rg/RBR-8h4dty	<NULL>	People with epilepsy diagnosed; both sexes; age between 18 and 60 years.	Impossibility to practice physical exercise; unable to answer a questionnaire; practice regular exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9vsnz4	Analysis of the implantation of the home mechanical ventilation on the better at home program	Not yet recruiting	Observational	2019-12-02	<NULL>	<NULL>	3238	Analysis of the implantation of the home mechanical ventilation (VMD) in services of the better at home program	<NULL>	3, n/a, n/a	3	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Alemão Oswaldo Cruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9vsnz4	<NULL>	Home care services that possess the minimum conditions of admission of patients in invasive ventilation; Patients in invasive mechanical ventilation, regardless of age and cause that led to chronic ventilation, with conditions to receive care at home; services, patients and caregivers who agree to participate in the study.	Home care services that are not interested in participating in the study; home care services that do not have the minimum structure for the safe dehospitalization of patients in mechanical ventilation; refusal of the patient and/or family member to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-4gq8mk	Metabolic and Respiratory Changes in Footballers	Data analysis completed	Intervention	2019-12-02	<NULL>	<NULL>	3239	Analysis of metabolic and respiratory changes in adolescent football athletes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-30	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4gq8mk	<NULL>	Healthy and hemodynamically stable volunteers; male gender; soccer athletes; age between 14 and 15 years.	Frequency of participation less than seventy-five percent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9zytwf	Effects of orthodontic treatment with clear aligner and conventional fixed appliance	Recruitment completed	Intervention	2019-10-25	<NULL>	<NULL>	3240	Effects of orthodontic treatment with clear aligner and fixed appliance: randomized clinical trial	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-06-12	Align Technology, Inc	Unopar	https://ensaiosclinicos.gov.br/rg/RBR-9zytwf	<NULL>	Fifteen to 35 years of age; both sexes; Angle Class I malocclusion; moderate anteroinferior crowding and treatment without extraction.	Absence of permanent teeth, anterior or posterior open bite, anterior or posterior crossbite, previous orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8zz8fw	Effect of Resistance Training on Blood Pressure in adolescents	Recruitment completed	Intervention	2019-12-02	<NULL>	<NULL>	3241	Responses and Adaptations of a Resistance Training Program in reducing Cardiovascular Risk Factors and their relationship with Post-exercise Hypotension in school adolescents in the city of Lagarto-SE	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8zz8fw	<NULL>	Healthy volunteers; Both genders; non smokers; age between 18 and 60 years	Sick volunteers; presence of secondary hypertension; pregnant teenagers; age over 18 years; resistance training practitioners; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-9ypbtf	Study of HPV Vaccine adverse events and protection in patients with Juvenile Lupus and Juvenile Dermatomyositis	Data analysis completed	Intervention	2019-12-02	<NULL>	<NULL>	3242	Study of safety and immunogenicity of the vaccine against human papillomavirus (HPV) in patients with Systemic Lupus Erythematosus (JSLE) and Juvenile Dermatomyositis (JMD)	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-11-03	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Departamento de Pediatria e Puericultura da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9ypbtf	<NULL>	Being female; Be between 9-20 years old; Have been diagnosed with one of the following immune system disorders before the age of 17 and before their first quadrivalent vaccine against human papillomavirus: juvenile systemic lupus erythematosus or juvenile dermatomyositis; Have not received the three doses of the quadrivalent human papillomavirus vaccine	The absence of parental consent for those under 18 or consent from the patient or control; refusal of any blood collection; hx of suspected or proven cervical carcinoma; being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-63rw34	Avaliation of effectiveness of a preemptive analgesia protocol in the extraction f third lower molars	Recruitment completed	Intervention	2019-12-03	<NULL>	<NULL>	3243	Efficacy of different analgesy protocols in the extraction of mandibular third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-17	Universidade Federal do Ceará- Campus Sobral	Universidade Federal do Ceará- Campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-63rw34	<NULL>	Having lower third molars; any indication of extraction; being over eighteen years old and less then forty years old; having teeth in similar positions according to the Winter and Pell and Gregory classifications; having teeth with at least two thirds of root formation	Allergies or adverse reactions to medications used; presence of any tooth-associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4zkjfx	Health education of patients with gastrointestinal neoplasia in antineoplastic chemotherapy and quality of life, functional capacity and fatigue	Recruiting	Intervention	2019-12-03	<NULL>	<NULL>	3244	Health education on quality of life, functional capacity and fatigue of patients with digestive system neoplasia in antineoplastic chemotherapy: a quasi experimental study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4zkjfx	<NULL>	The study will include patients diagnosed with CA of the digestive system aged 18 years or older undergoing intravenous antineoplastic chemotherapy treated at the HC / UFTM chemotherapy service. To this end, they agreed to participate in the study by signing the Informed Consent Form, as well as the Free Informed Consent Form prepared according to Resolution 466/12 of the National Health Council (BRAZIL, 2012).	Will be excluded from the study patients who underwent antineoplastic chemotherapy treatment and / or previous radiotherapy; in adjuvant radiotherapy treatment; diagnosis of metastatic AC, which will perform less than three treatment cycles and / or change chemotherapy protocol during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5wmn5k	Effect of stretching exercises on balance in older women	Data analysis completed	Intervention	2019-12-03	<NULL>	<NULL>	3245	Effect of flexibility training on postural control in older women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-12	Escola de Enfermagem Aurora de Afonso Costa- Universidade Federal Fluminense	Instituto de Educação Física -UFF	https://ensaiosclinicos.gov.br/rg/RBR-5wmn5k	<NULL>	Inclusion criteria were: elderly women aged 60 years or older, those who independently maintained their daily activities through the Baecke Modified Questionnaire, elderly women who practiced only the Prev Quedas water exercise, without participating in another exercise program. physical and those who presented medical examination authorizing the practice of physical exercises.	Exclusion criteria were: elderly women with diseases diagnosed by the doctor that compromised postural control, such as blindness or low vision, labyrinthitis, osteomioarticular diseases, Parkinson&apos;s disease and Alzheimer&apos;s disease, low cognitive ability, previous history of stroke and fall; elderly women who presented two consecutive or more absences in the proposed training, without replacement, in the same week of absence or in the following week; elderly women with a history of falling in the last 12 months; elderly women with low cognitive ability verified through the Mini Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-2btctk	Physical Training in Postmenopausal Obese Women	Data analysis completed	Intervention	2019-12-03	<NULL>	<NULL>	3246	Physical Training in Postmenopausal Obese Women: Evaluation and Intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade de Educação Física e Fisioterapia	Faculdade de Educação Física e Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-2btctk	<NULL>	The inclusion criteria will consist of: Being between 45 and 65 years old; be obese, do not have physical problems or cardiovascular complications that prevent the performance of physical activities; have no history of any serious pathology; present a medical certificate confirming that they are able to practice physical exercise; not being a smoker; not make use of alcoholic beverages; have the menstrual cycle interrupted for another 12 months	"The criteria for not including the study will be: Make use of hormone replacement therapy; present a diagnosis of serious illnesses or
that compromise physical activity"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-9qwppm	3D Changes Associated with Surgically Assisted Rapid Palatal Expansion (SARPE): Cranial Base Overprint	Data analysis completed	Intervention	2019-12-04	<NULL>	<NULL>	3247	Surgically assisted rapid maxillary expansion (ERMAC): dental and skeletal effects assessed by cone-beam computed tomography	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade de São Paulo (USP)	Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-9qwppm	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; weight within the range of 15% of the weight considered normal for men and women, taking into account the height and physical structure, which have transverse maxillary deficiency and broad oral corridors.	Volunteers with untreated periodontal disease and / or caries lesions; systemic diseases; use of drugs that may alter bone metabolism; mechanical complications of the expanders and absence of CBCT images.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4pysrs	University extension project for atraumatic treatment of dental caries: from assistance to sustainability, interaction between university and public health	Data analysis completed	Intervention	2019-12-04	<NULL>	<NULL>	3248	University extension project on Atraumatic Restorative Treatment: from assistance to sustainability, interaction between university and public health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-15	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4pysrs	<NULL>	"Presence of one or more caries lesions in enamel and / or
dentin in deciduous or permanent elements; age between 6 and 14 years old; both genders"	Absence of restorations or caries lesions on primary or permanent teeth; age below 6 years or above 14 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-95ddhp	Assessment of eye inflammation after intravitreal injection injection	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3249	Randomized, double-blind clinical trial to evaluate inflammation following intravitreal injection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-95ddhp	<NULL>	Patients with indication for intravitreal anti-VEGF injection followed by vitrectomy to treat complications of diabetic retinopathy.	Glaucoma; previous or current history of uveitis; previous vitreoretinal surgery; patients who have contraindications to the use of anti-VEGF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-6fb473	Assessment of Gynecological and Dermatological Acceptability of Health Product under Normal Conditions of Use	Recruitment completed	Observational	2019-12-05	<NULL>	<NULL>	3250	Assessment of Gynecological and Dermatological Acceptability of Health Product under Normal Conditions of Use_MKLAB	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-6fb473	<NULL>	"Women; Age 18 to 65 years old; Phototype I to IV
Whole skin of the region; Occasional user of category products"	"Skin markings in the experimental area that interfere with the evaluation of possible reactions
Pregnant or lactating women;
Participants with a history of allergy to the material used in the study;
History of atopy;
Use of vaginal cream;
Participants with a history of allergy to products of the tested category;
Recent gynecological surgeries;
Discharge;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis)
Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-69c4qq	Effect of aged garlic extract on cardiovascular health: a randomized 12-week placebo-controlled study	Recruiting	Intervention	2019-06-03	<NULL>	<NULL>	3251	The effect of aged garlic extract on the blood pressure of hypertensive patients and their relationship to the nutritional status of vitamins b6, b9 and b12	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-04-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-69c4qq	<NULL>	Arterial hypertension	Psychiatric disorder; allergy to garlic and sulfur; terminal illness; anemia; infection; pregnancy; use of multivitamin or garlic supplement in the last 6 months; can not give informed consent; are participating in another clinical trialand and malnutrition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-33mj49	Comparison of Tomography with Clinical and Surgical Evaluation in the Diagnosis of Bone Defects	Recruitment completed	Observational	2019-12-05	<NULL>	<NULL>	3252	Accuracy of Cone-Beam Computed Tomography in Defining the Type of Furcation Injury in Upper Molars	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade Federal de Goiás	UniEvangélica	https://ensaiosclinicos.gov.br/rg/RBR-33mj49	<NULL>	patients older than 18 years with periodontitis in upper molar teeth; who underwent previous non-surgical periodontal therapy and showed no improvement in periodontal disease.	Maxillary molars with furcation injury that simultaneously had caries; cervical resorption; fused roots; metallic crowns or amalgam restorations near the alveolar bone crest; Endodontically treated teeth that could generate artifacts compromising image quality; Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-9d78qy	Effect of gum treatment in hypertensive patients	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3253	Effect of non-surgical periodontal Treatment in patients with periodontitis and Refractory Arterial Hypertension	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-9d78qy	<NULL>	Patients over 35 years old; Have at least 12 teeth present; Diagnosis of generalized periodontitis according to periodontal classification: insertion loss in 2 non-adjacent interproximal sites, clinical insertion loss (CIN) greater than or equal to 3mm in 2 teeth, except for: gingival recession, dental caries, endoperiodontal injury, occurrence root fracture, presence of loss of insertion in the distal face of a second molar and associated with poor positioning or extraction of the third molar; a gingival condition would be described as localized when less than 30% of the teeth are affected; greater than 30% of teeth are affected by periodontal disease; Patients diagnosed with major refractory arterial hypertension equal to 140 and / or 90mmHg.	Smokers or former smokers less than 12 months old; Patient with anemia; Active cancer patient; Patient with blood disorders; Pregnancy; Patient with chronic kidney disease; Patient with decompensated Type II Diabetes Mellitus; Bacterial endocarditis; Having received some kind of prior periodontal therapy; Patient using any medication such as antibiotic or anti-inflammatory and systemic conditions that affect the progression or periodontal treatment; Patient undergoing chemotherapy and / or head and neck radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-24vtrb	Effectiveness of nursing intervention to prevent falls in the elderly	Not yet recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3254	Effectiveness of a nursing intervention instrument for fall prevention in hypertensive elderly	<NULL>	n/a, single-arm-study, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-02	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-24vtrb	<NULL>	Elderly with systemic arterial hypertension; have Nursing Diagnosis Risk of falls; being accompanied and registered at the Basic Health Unit I, headquarters II or Boa Fé; have an age greater than or equal to 65 years or greater than or equal to 75 years; live with a partner or family members.	Elderly with diabetes mellitus; have some mental disorder; elderly traveling on the day of recruitment of the survey participants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4fgknb	Effects on blood pressure of conventional strength training, handgrip training and combined training (strength training + handgrip training)	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3255	Cardiovascular Effects of Dynamic, Isometric and Combined (Dynamic + Isometric) Resistance Training in Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-4fgknb	<NULL>	Men between 30 and 65 years old; with diagnosis of hypertension and under antihypertensive medication with drug and dose maintained at least in then previous 4 months; not taking anti-hypertensive drugs that directly affect cardiac autonomic regulation (such as beta-blockers and non-dihydropyridine calcium channels inhibitors); not practicing physical exercise more than twice a week or more than 150 minutes/week; no resistance exercise practice in the previous 6 months.	Presence of secondary hypertension and/or target-organ lesion; systolic/diastolic blood pressures equal to or greater than 160/105 mmHg; obesity level II or superior; other cardiovascular diseases besides hypertension; diabetes with complications or in use of insulin; presence of osteoarticular diseases that limit resistance exercise execution; electrocardiographic alterations during maximal exercise  test that suggest cardiovascular diseases; change in dose or medication during the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-27j6zg	Aerobic training at different times of day: Vascular and autonomic adaptations in hypertensive elderly	Recruiting	Intervention	2019-12-06	<NULL>	<NULL>	3256	Aerobic training at different times of day: Vascular and autonomic adaptations in hypertensive elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27j6zg	<NULL>	Men and women; age between 60 and 90 years; hypertensives receiving anti-hypertensive drugs for 4 or more months; neither receiving beta-blockers nor non-dihydropyridine calcium channel blockers; neither chronotype type; inactive or insufficiently active; available to participate in the interventions at both proposed times of day (morning and evening), not taking any hormone replacement.	Presence of cardiovascular diseases beyond hypertension; presence of osteomioarticular problems that unavailable to practice exercise; systolic and diastolic blood pressures higher than 160 and 105 mmHg, respectively; obesity level 2 or above; presence of diabetes with complications or receiving insulin; presence of organ-target damage; presence of complex arrhythmias and/or ischemia during exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-3y869j	Delay in surgery following neoadjuvant chemotherapy in advanced ovarian cancer	Recruiting	Intervention	2019-12-06	<NULL>	<NULL>	3257	Retarded surgery following neoadjuvant chemotherapy in advanced ovarian cancer	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2019-09-26	Vanessa da Costa Miranda	Instituto do Cancer do Estado de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3y869j	<NULL>	"A subject will be considered eligible for inclusion in this study if all the following criteria are met: Female patients more than 18 years;
histologically confirmed epithelial ovarian cancer, fallopian tube carcinoma or primary peritoneal carcinoma, high grade serous or endometrioïd, with the exception of mucinous, clear cell and carcinosarcoma histologies; performance status less than 2; documented International Federation of Gynecologic Oncology (FIGO 2014, Appendix 1) stage IIIB-IIIC-IV unsuitable for complete primary cytoreductive surgery (confirmed by open laparoscopy or by laparotomy); patient must be judged resectable after 3 courses of Neoadjuvant chemotherapy; adequate bone marrow, liver and renal function to receive chemotherapy and subsequently to undergo surgery: white blood cells (WBC) more than 3x109/L, absolute neutrophil count (ANC) more than 1,5x109/L, platelets (PLT) more than 100x109/L, hemoglobin (Hb) more than 9 g/dL, serum creatinine less than 1.25 x upper normal limit (UNL) or creatinine clearance more than 30 mL/min, serum bilirubin less than 1.25 x UNL, AST(SGOT) and ALT(SGPT) less than 2.5 x UNL; signed informed consent obtained."	Subjects meeting any of the following criteria must not be enrolled in the study: Mucinous, clear cell , carcinosarcoma and low grade serous carcinomahistologies; synchronous or previous other malignancies within 3 years prior to starting study treatment, with the exception of adequately treated non-melanomatous skin cancer or carcinoma in situ (of the cervix or breast or other sites); patients with brain metastases, seizure not controlled with standard medical therapy, or history of cerebrovascular accident (CVA, stroke) or transient ischemic attack (TIA) or subarachnoid hemorrhage within 6 months from the enrollment on this study; any other concurrent medical conditions contraindicating surgery or chemotherapy that could compromise the adherence to the protocol; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5m42mh	Effectiveness of a protected activation exercise program in patients with arthroscopic rotator cuff surgery	Recruiting	Intervention	2018-12-18	<NULL>	<NULL>	3258	Effectiveness of a supervised early exercise program in patients with arthroscopic rotator cuff repair: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-5m42mh	<NULL>	Subjects of both genders; whose age range is between 18 and 55 years with medical diagnosis of total rupture of the supraspinatus muscle, based on clinical and imaging criteria (ECOTOMOGRAPHY and MRI); submitted to arthroscopic repair with simple suture by the team of Traumatologists of the HCSB Arriarán; accept and sign the informed consent.	subjects with massive rotator cuff tear (2 or more tendons and / or injury greater than 5 cm) and with presence of associated lesions Example; Glenohumeral Instability; Adhesive Capsulitis; Cervical Hernia etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-6685wt	Clinical evaluation of Ozone gas efficiency on Tooth sensitivity and Tooth whitening	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3259	Clinical evaluation of the toxicity and efficiency of Dental Bleaching associated with Ozone gas	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-6685wt	<NULL>	The third molars must be sound; and with initial color of teeth A2 or more saturated.	Pregnant and lactating patients; patients who had teeth with severe internal discoloration (resulting from tetracycline stains, fluorosis or endodontic treatment); patients with teeth under potential conditions for sensitivity, such as gingival recession, dentin exposure and poor enamel formation; patients who reported sensitivity already existing at the time of the anamnesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8w8599	Effect of Anti Microbial Photodynamic Therapy on the Treatment of Oral Candidosis	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3260	Use of Anti-Microbial Photodynamic Therapy in the treatment of Oral Candidose: Clinical, controlled and randomized test	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-08	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8w8599	<NULL>	Cases of patients with erythematous candidiasis located in the oral mucosa; Patients older than 18 years and under 100 years old; Patients who do not receive treatment for other diseases with systemic antifungal	Patients with other types of oral candidiasis; Pregnant women; Patients who did not receive nystatin treatment at least six months prior to the start of the study; Patients who do not attend for follow-up;Patients older than 100 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-35w9bw	Effects of whole-body vibration on biomarkers of the elderly at different stages of sarcopenia	Recruiting	Intervention	2019-12-09	<NULL>	<NULL>	3261	Effect of the stimulation of the whole body vibration in parameters neuroendocrine-inflammatory and redox status of elderly people in different stages of sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-15	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-35w9bw	<NULL>	Persons of both sexes aged 60 years and over; Postmenopausal women; Have not participated in any physical training program in the three months prior to the beginning of the assessments; Do not have acute illness that prevents the carrying out of the assessments; have a chronic disease, it is controlled, not being on immunosuppressive and / or anti-inflammatory medication, not presenting symptoms suggestive of cognitive impairment, according to the Mini-Mental State Examination.	Presence of epilepsy; gallstones; kidney stones; neuromuscular and neurodegenerative diseases; stroke/strokes; serious heart disease or those who have an implant; by-pass or stent; and refusal to sign the Informed Consent Term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-7rwgzt	Effect of Brazil Nut consumption on mineral Selenium compounds in the continuous use of cholesterol-lowering drugs	Data analysis completed	Intervention	2017-08-07	<NULL>	<NULL>	3262	Effect of Brazil Nut (Bertholletia excelsa H.B.K.) consumption on Selenocomposites in the chronic use of Statins	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rwgzt	<NULL>	Adults subjects of both sexes; in chronic use of Statins; with muscle disorders in the case of individuals in the study group; no muscle disorders in the case of individuals in control group	Presence of serious cardiac complications or other diseases such as thyroid; hematological; congenital; autoimmune; liver disease; renal failure; cancer; associated infections; osteoporosis; postoperative; antibiotics and vitamin and mineral supplements; food allergy to oilseed; current alcoholism and smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8pfq8c	Functional exercise program associated with neuromodulation in pain, physical abilities and quality of life of patients with fibromyalgia.	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3263	tDCS Associated Functional Exercise Program in pain, functional Performance and quality of Life of Fibromyalgia Patients: Randomized, placebo-controlled, Double-Blind Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Monayane Grazielly Leite Matias	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8pfq8c	<NULL>	Being a woman diagnosed with fibromyalgia in the age group between 30 and 70 years old; present availability to attend the intervention; not hypersensitive to electric current; have not had previous treatment with tDCS; have not performed regular exercise in the last 3 months; and have a medical certificate allowing the practice of exercise.	Presence of epileptic disease, history of seizure, psychiatric disorders, presence of rheumatic disease, except Fibromyalgia; pregnancy, metallic brain implant; at any time and for whatever reason express a desire to leave the study; missing during the ETCC protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4zsf45	Effects of pulmonar expansion maneuver on pulmonar complications in children after immediate heart surgery	Recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3264	Effects of alveolar recruitment maneuver on complications pulmonary disorders in children in the immediate postoperative Congenital Heart Diseases: A Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-11	Hospital martagão gesteira	Hospital martagão gesteira	https://ensaiosclinicos.gov.br/rg/RBR-4zsf45	<NULL>	All children between 6 months and 6 years, who have had cardiac surgery of congenital heart disease with median sternotomy who have been admitted to mechanical ventilation and remain on the ventilator during the proposed intervention period will be included.	Children with hemodynamic instability, such as hypotension, psychomotor agitation, previous pneumonectomy, bronchopleural fistulas, hemoptysis, non-drained pneumothorax, and hypertension will be excluded if they present with a chest deformity, difficulty or inability to swallow and release airways that do not present cough reflex, intracranial. In addition, children with neuromuscular diseases will be excluded; children who have suffered neurological complications during the postoperative period; children who develop dependence on MV and still need to be transferred from the ICU of Martagão Gesteira Hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5d27tn	Study comparing the incidence of complications between different cutting modalities in endoscopic biliary access	Recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3265	Prospective randomized trial comparing the incidence of adverse events between pure cut and endocut cutting modes employed in endoscopic sphincterotomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-08	Faculdade de Medicina da Universidade São Paulo	Faculdade de Medicina da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5d27tn	<NULL>	"Patients with indication for ERCP with papillary papillotomy without previous papillotomy
Older than 18 years
Agreement with the consent form
Selective cannulation of the biliary tract through the major duodenal papilla"	"Non-acceptance of the consent form
Previous papillotomy
Incorrigible coagulopathy
Need for cannulation of the biliary tract by advanced modalities: Fistula; Precut, transpancreatic sphincterotomy
Surgical history that does not allow endoscopic access to the biliary tract (Billroth II, Roux-en-Y gastrectomy, etc.)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-6nj4mk	Effects of Aquatic Physiotherapy on Epigenetic, Inflammatory and Neutotrophic factors in Parkinson&apos;s disease patients	Data analysis completed	Intervention	2019-12-10	<NULL>	<NULL>	3266	Effects of an Aquatic Physical Activity program on clinical-functional parameters, peripheral modulation of epigenetic mechanisms, inflammatory markers, and Brain Derived Neurotrophic Factor (BNDF) levels in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-6nj4mk	<NULL>	As inclusion criteria for both control and exercise groups, subjects should present Parkinson Disease diagnosed by a neurologist (rule out parkinsonisms with other causes). In addition, they must be able to participate in the proposed physical activity program and sign the consent form. The participants need to be between 50 and 80 years old.	As exclusion criteria for both CONTROL AND EXERCISE groups, the individual should present characteristics of cognitive deficits verified through the application of the MoCa Questionnaire. Specifically for the EXERCISE group, as exclusion criteria, aspects such as the inability to participate in aquatic physiotherapy will be adopted, besides the individual presenting other diagnosed neurological and orthopedic pathologies that preclude their participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-3dgcpv	Is it safe to prescribe antibiotics at the commonly administered dose for patients with stomach reduction surgery? Study of available concentration of oral amoxicillin	Data analysis completed	Intervention	2016-12-05	<NULL>	<NULL>	3267	Is it safe to prescribe antibiotics in tablets dosage form for bariatric patients? Oral bioavailability study of amoxicillin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-09	Núcleo de Pesquisa Clínica e Bioequivalência	Universidade Estadual de Maringá (UEM)	https://ensaiosclinicos.gov.br/rg/RBR-3dgcpv	<NULL>	"Health volunteers who have undergone bariatric surgery by the technique Roux in Y gastric band at least 3 months ago;
To be over 18 years or under 55 years old;
Has signed the Written Informed Consent Form."	"Intolerance or hypersensitivity to Amoxicillin;
Renal or hepatic faillure;
Pregnancy;
Brest-Feeding;
Alcohol or illicit drugs user;
Use of prokinetic drug (metoclopramide, erythromycin or domperidone);
Enrollment at Clinical Study in the last 3 months;
Show thrombocytopenia, anemia;
Bariatric patients by others techniques then Roux in Y gastric band;
Be under 18 or over 55 years old;
Bariatric surgery over 5 years ago;
Bariatric surgery for less than 3 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-92m2m9	Active mind: cooking and gardening class for healthy aging	Recruitment completed	Intervention	2019-12-10	<NULL>	<NULL>	3268	Envelhecimento saudável com oficinas de culinária e horta: um estudo de intervenção para idosos da coorte EPIDOSO	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92m2m9	<NULL>	To be eligible should be participant from the EPIDOSO cohort study; aged people more than 60 years old; Clinical Dementia Rating (CDR) scored zero or half; respectively; no dementia and questionable dementia; both sexes.	Dementia diagnosed by trained gerontologist with Clinical Dementia Rating -CDR (CDR=1 is mild dementia, CDR=2 is moderate dementia and CDR=3 is severe dementia); depression (escala de depressão em idosos-GDR=5); gastrectomia; HIV positive; alcoholist; chronic renal failure; multiple sclerosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-2m93s5	Evaluation of elasticity, color change and ultrastructure of aesthetic orthodontic ligatures	Data analysis completed	Intervention	2019-12-10	<NULL>	<NULL>	3269	Aesthetic elastomeric orthodontic ligatures: Evaluation of Elastic Properties, Color Change and Ultra Surface Structure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m93s5	<NULL>	Patients aged between 12 and 20 years; with good general and dental health; without metal tooth restorations; in orthodontic treatment and without having used mouthwashes in the last 3 months before the beginning of the experiment	Patients with some type of systemic disease; with poor dental health as the presence of dental caries, periodontal disease; or who regularly use mouthwashes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8mdyhd	Evaluation of the efficacy of listening to music on anxiety, blood pressure, heart rate, respiratory rate, oxygen saturation and pain after cardiac surgery: a randomized clinical trial.	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3270	Effect of musical hearing on anxiety, pain and cardiorespiratory parameters in cardiac surgery: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8mdyhd	<NULL>	Patients undergoing elective cardiac surgery by median longitudinal sternotomy during the data collection period.	Patients who are unable to maintain dialogue with the researcher; who have deficit or hearing and / or cognitive impairment; who are using sedative or anxiolytic medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-2vmpz9	Effects of a Formulated Drink on post exercise Recovery	Recruitment completed	Intervention	2019-12-10	<NULL>	<NULL>	3271	Effects of a Formulated Drink on post exercise Recovery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2vmpz9	<NULL>	Healthy volunteers; College students; male; age between 18 and 30 years; regular frequency of soccer practice at least twice a week.	Volunteers who took drugs, smokers, who used dietary supplements (multivitamins or protein supplements) in the last three months; milk allergy; were injured and / or ill in the last month prior to the start of the study; those who expressed interest in abandoning the study or presenting a factor such as injury and / or need for drug treatment during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8zh26b	Consequences of tooth movement with fixed braces in bone grafted regions	Recruitment completed	Intervention	2019-12-11	<NULL>	<NULL>	3272	Effects of the movement of the teeth with orthodontic appliance, in graft bone regions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Faculdade de Odontologia da Universidade Federal da Bahia	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8zh26b	<NULL>	"Patients of both genders, older than 18 years, who are being treated at the UFBA Orthodontics specialization clinic will be included.
They have had lower first molars absent, with atrophy of the bony ridge in vestibular-lingual thickness; presence of second and third adjacent lower molars; first molar superior extruded antagonist and general good health. In addition, they should have in their treatment plan autogenous bone graft in the edentulous region of the first lower molar, uni or bilateral; mesialization of the second and third lower molars, uni or bilateral; and intrusion of the first molar upper antagonist."	Patients with systemic diseases or changes or syndromes will be excluded; medicines that may affect bone metabolism and or root resorption index; and who had a history of trauma in the teeth studied. In addition, smokers and pregnant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-86xv46	Effects of a school intervention on adolescent health	Not yet recruiting	Intervention	2019-12-11	<NULL>	<NULL>	3273	Effects of a school-based intervention on executive function, sedentary behavior and nutritional status of adolescents	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-86xv46	<NULL>	State public schools that work with elementary school from 7th to 9th grade; Have spaces for the practice of physical activities, such as courts and gyms; Adolescents between 12 and 16 years old and properly enrolled.	Physical disability; Intellectual disability; Endocrine disorders; Cardiovascular disease; Diabetes mellitus; Be pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-6nv3c5	Effect of the use of a cream with leucine and lactic acid associated with electrostimulation in contouring facial	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3274	Development of a cream containing leucine and lactic acid to increase facial muscle tone in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-26	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nv3c5	<NULL>	Female sex; be healthy; body mass within the range of 15% of the weight considered normal for men and women, taking into account height and physical structure; skin photo type 1 to 4 (color of skin)	Present any type of physical or mental diseases, which interfere with the use of cream in a continuous form and  in the evaluation measures, have carried out some sort of facial surgery, deficiency or absence of cutaneous sensibility, presence of scars, allergies, hematoma and/or abrasions on the face, perform any type of treatment in aesthetic centers during the study period. Women  were also excluded from the study  with occurrence of tooth pain, pregnant or lactating diseases with infectious process and/or inflammatory process in facial region, acne grade 3, use of pacemakers and metal plates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-6rkfp2	Clinical evaluation of Ion z glass ionomer cement restorations in children	Recruitment completed	Intervention	2019-12-12	<NULL>	<NULL>	3275	Efficacy of Ion Z glass cement in microbin control in carie inclusive interior dentina	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-09	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6rkfp2	<NULL>	"Children who are 4 to 7 years old;
IC signed by the parent or guardian of the child;
TA filled in by the children;
Present at least 1 deciduous molar with carious lesion on the occlusal surface, with radiographic depth in the inner half of dentin;"	"The exclusion criteria:
Children who exhibit inappropriate behavior during dental care;
Decayed teeth with clinical and radiographic signs of pulp involvement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-9yqtqn	Using Artificial Intelligence techniques to understand the cardiorespiratory system	Recruiting	Observational	2019-12-12	<NULL>	<NULL>	3276	Machine Learning Techniques for Modeling the Aerobic System	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal de São Carlos (UFSCar)	Universidade de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-9yqtqn	<NULL>	Will be included volunteers men and women; with a body mass index of less than 35kg / m2; non-alcoholic; non-drug users; non-neurological or osteoarticular disease patients that impede the exercise protocol	Volunteers who exhibit electrocardiographic changes at rest; clinical exercise test (ST segment depression; ventricular; supraventricular arrhythmias; atrial fibrillation; atrioventricular block; sustained supraventricular tachycardia; non-sustained atrial tachycardia) are excluded; do not complete all of the proposed assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8pxcth	Crr: Cardiac Resuscitation Project	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3277	RCR Project - Prototype for Basic Life Support	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8pxcth	<NULL>	Young people between 18 and 40 years old; healthy; know how to apply cardiac massage; belong to healthcare	Not knowledge of the technique; upper limb orthopedic disease; upper limb pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7cbqt3	Analysis of particle diameter influence of a bone substitute of bovine origin, in the repair of bone surrounding the dental element, submitted to bone preservation technique after extraction. Randomized Clinical Trial.	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3278	Analysis of the influence of a xenogenic bone substitute particle&apos;s diameter on reparation of fresh dental alveoli, submitted to alveolar preservation. Randomized clinical study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-7cbqt3	<NULL>	Thirty dental elements, incisors and maxillary premolars will be used, indicating extraction, and all adult participants of both genders	Active periodontal disease or previously affected teeth; current or previous smoker; head and neck radiotherapy; medical contraindication for dental surgery; diabetes; use of bisphosphonate and / or cyclosporine medicines; osteoporosis; osteopenia and periapical lesions on adjacent teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-2t5zpd	Supplementation of turmeric compounds in hemodialysis patients	Recruitment completed	Intervention	2019-12-12	<NULL>	<NULL>	3279	Supplementation of bioactive compounds in hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-14	Faculdade de Nutrição - Universidade Federal de Goiás	Fundação de Amparo a Pesquisa do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2t5zpd	<NULL>	Patients of both sexes, from 20 to 70 years old, under treatment of HD&gt; three months with access by arteriovenous fistula.	Pregnant women; nursing mothers; amputees; patients who report allergy or intolerance to curcuma ou piper nigrum; or present: infectious process; chronic liver disease; sepsis; intestinal malabsorption; cancer; Acquired immunodeficiency syndrome; patients with difficulty swallowing; recent hospitalization (&lt;3 months); decompensated diabetes; those who are consuming vitamin supplement or non-steroidal anti-inflammatory drug.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-4msyxn	Evaluation of temporary crowns made by conventional and 3D printed materials: Randomized clinical trial	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3280	Evaluation of implant-retained temporary crowns made by conventional and 3D printed materials: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-19	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4msyxn	<NULL>	To be included in the sample, patients will need to have the following characteristics: Having previously performed the installation of dental implants, which are considered osseointegrated, thus enabling the manufacture of prostheses on the implants; Have indication of making a temporary cemented crown on the implant using prosthetic component of the trunnion type; Have good general health, which allows dental treatment; Have time and time available to attend dental appointments at the institution.	Patients with any of the following characteristics may not be part of the sample: Patient with any systemic disease that prevents dental treatment; Patients who do not have time available for care in educational institutions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-54dqtf	Physiotherapy and burns	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3281	Physical therapy in burn patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-12	Faculdade de Ceilândia - Fundação Universidade de Brasília	Hospital Regional da Asa Norte – HRAN	https://ensaiosclinicos.gov.br/rg/RBR-54dqtf	<NULL>	Subjects over 18 years old with a diagnosis of hypertrophic scars; subjects who have 4 regions with hypertrophic scars	Subjects diagnosed with diabetes mellitus; diseases related to collagen production; subjects using corticosteroids; subjects with keloid diagnosis; subjects who have contact dermatitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-5wsz24	Evaluation of the effect of the drug Ketorolac Trometamol compared with physiotherapy treatment in patients with temporomandibular dysfunction	Recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3282	Evaluation of therapeutic efficacy of Cetorolaco Trometamol in comparison of Physiotherapic treatment in patients with Temporomandibular Dyfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5wsz24	<NULL>	"Patients of both sexes, from 18 to 50 years old;
Diagnosis of Temporomandibular Joint / Muscular Dysfunction (TMD), with pain for at least 60 or 90 days, confirmed after clinical evaluation by a dental professional;
Patient examined and considered in good health, according to medical judgment, without severe comorbidities; Patient is able to understand the nature and purpose of the study, including the risks and adverse effects and with the intention to cooperate with the researcher and to act in accordance with the requirements of the entire protocol, which is confirmed by signing the Terms of Reference. Informed Consent, performed before any procedure."	Patient has known hypersensitivity to non-steroidal anti-inflammatory drugs or a history of serious adverse reactions to any medicinal product. Body mass index (BMI) less than 18 or greater than 30; Current or recent history (within the last 12 months) of drug, drug or alcohol abuse; He was hospitalized for any reason for four weeks prior to the start of the study; Patients with a clinical history of serious heart, kidney, liver and lung disorders; Pregnant and / or nursing women; Patient undergoing specific treatment (orthodontic) for TMD at least 02 months; Patient using any medication with analgesic and / or anti-inflammatory action that cannot be suspended during the wash out period, which corresponds to 5 times the half-life of the drug; Participation in any experimental study or ingestion of any experimental drug three months prior to commencement of this study; EVA less than 05; Has any condition that the investigator deems relevant for non-participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7mz2kr	Effects of multicomponent exercise program in the group and/or  at home in community-dwelling older adults	Not yet recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3283	Effects of center and/or home-based multicomponent exercise program in community elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7mz2kr	<NULL>	60 years of age and over; not participating in an exercise program for 6 months prior to project participation	Physical restrictions to perform the tests and/or exercises; cognitive deficits based on the Mini-Mental State Examination scores adjusted by educational level; medical contraindications for participation in exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8dqcfw	Life skills in medical students	Recruitment completed	Intervention	2019-12-12	<NULL>	<NULL>	3284	Life Skills in Medical Students	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-8dqcfw	<NULL>	The individuals included in this study will be the students from the 1st to the 6th year of the medical school; of both sexes; aged 18 to 70 years; who are regularly enrolled in the course and who agree to participate in the study through the Informed Consent Form.	Academics who refuse to answer or who incompletely answer the data collection instruments will be excluded from the research; who are not regularly enrolled in the course; that belong to other courses of the institution and that present impossibility of verbal and visual communication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-5dfqzp	Evaluation of the effect of photobiomodulation on the control of symptoms of patients with burning mouth syndrome	Recruiting	Intervention	2019-12-13	<NULL>	<NULL>	3285	Evaluation of the effect of Photobiomodulation on the control of symptoms of patients with Burning mouth syndrome: controlled, randomized and double-blinded study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-16	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dfqzp	<NULL>	Patients will be recruited from those undergoing treatment on the Oral Diagnostic Center, School of Dentistry, University of São Paulo  diagnosed with Burning mouth syndrome and whom agree to participate by reading and signing the consent form	Patients with another condition such as candidiasis hyposalivation and nutritional deficiencies; possibly have the origin of the oral symptomnsthese changes and will be excluded from the study as well as those who cannot attend to the  clinic for low-level laser application or is currently using clonazapem	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-65336k	Randomized Clinical Trial of the antibacterial effect, clinical and radiographic success of endodontic treatment in primary teeth	Recruiting	Intervention	2019-12-13	<NULL>	<NULL>	3286	Randomized Clinical Trial of the antibacterial effect, clinical and radiographic success of endodontic treatment in primary teeth using different root canal irrigants and chemical auxiliaries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Valdineia Maria Tognetti	Valdineia Maria Tognetti	https://ensaiosclinicos.gov.br/rg/RBR-65336k	<NULL>	Participants whose parents and / or guardians agree to participate in the survey; participants without systemic impairment and with no medical history of local and systemic allergic reactions to any medications; participants not submitted to antibiotic therapy at least one month before microbiological collection; participants with at least one deciduous tooth (anterior or posterior) with clinical and radiographic diagnosis of pulp necrosis due to carious lesion; teeth in condition to be restored; deciduous teeth with at least two thirds root remaining; with degree 0 (absent) or 1 (slightly higher than normal) mobility; with absence of periodontal pocket; no previous endodontic treatment; no internal resorption	Participants who do not agree or participate in the study or do not collaborate with it will be excluded; with systemic changes; who have been on antibiotic therapy at least one month before the start of treatment and / or during the evaluation period; deciduous teeth with reversible pulpitis; not recoverable; with extensive pathological internal and external resorption; excessive mobility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8k345j	Effect of pentoxifylline use on cardiac function in patients with chagasic cardiomyopathy	Recruitment completed	Intervention	2019-12-13	<NULL>	<NULL>	3287	Effect of prolonged use of Pentoxifylline on myocardial perfusion abnormalities, arrhythmic events and the evolution of left ventricular systolic dysfunction in chronic chagasic cardiomyopathy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k345j	<NULL>	The patients will be recruited from the population already attended at the specialized outpatient clinics of the Cardiology Center of the University of Ribeirão Preto Medical School Hospital das Clínicas. The study will include patients with a diagnosis of chronic chagasic heart disease confirmed by two distinct serological tests indirect immunofluorescence and enzyme immunoabsorption assay showing typical left ventricular segmental parietal mobility changes evidenced by transthoracic echocardiography that characterize chronic myocardial involvement by the disease. Study participants should have preserved left ventricular ejection fraction or with a slight reduction greater than 35%, may exhibit mild symptoms of heart failure	Patients with another etiology for myocardial dysfunction such as alcoholism will be excluded, previous myocardial infarction, known coronary artery disease, use of cardiotoxic or illicit drugs and peripartum cardiomyopathy, primary valvular heart disease and pericardial disease. Patients with comorbidities that compromise functional capacity such as severe chronic obstructive pulmonary disease will also be excluded; severe liver disease; collagenosis, untreated thyroid dysfunction. Coronary artery disease should be excluded by cardiac catheterization in those patients with ischemic perfusion defects on myocardial perfusion scintigraphy who exhibit 2 or more risk factors for atherosclerotic coronary artery disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-867k9g	Effects of a single session of Exercise in the blood pressure of patients with Rheumatoid Arthritis and High Blood Pressure	Recruiting	Intervention	2019-12-13	<NULL>	<NULL>	3288	Effects of a single session of Aerobic Exercise on blood pressure at rest, in response to stressful stimuli and in ambulatory conditions in Hypertensive patients with Rheumatoid Arthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-21	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)	Faculdade de Medicina, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-867k9g	<NULL>	Female sex; 20-60 years; hypertension; rheumatoid arthritis diagnosis; under usual care of the rheumatoid arthritis outpatient care at the Hospital das Clínicas of the Faculdade de Medicina of the Universidade de São Paulo.	Established cardiovascular and metabolic diseases; musculoskeletal problems that preclude the participation in exercise; ischemia or severe arrhythmias at rest or in the exercise test; class II obesity; use of medication that directly affect the autonomic nervous system (beta-blockers and non-dihidropiridin calcium blockers).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-22pqs9	The effect of bioactive compound supplementation on obesity treatment	Recruiting	Intervention	2019-12-17	<NULL>	<NULL>	3289	Bioactive compounds supplementation effects on the gene expression of inflammatory markers and macrophage infiltration in obese women	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-06-01	Flávia Campos Corgosinho	Faculdade de Nutrição - Universidade Federal de Goiás (FANUT-UFG)	https://ensaiosclinicos.gov.br/rg/RBR-22pqs9	<NULL>	Obese women with BMI above 40kg / m² between 20 and 59 years of age.	Presence of acute inflammatory diseases; infectious diseases; neoplastic diseases; genetic syndromes; present age under 20 years; chronic consumption of vitamin supplements; alcohol (&gt; 30g / day) (SBD, 2017); illicit drugs; do not live in the metropolitan region of goiania; swallowing problems and presenting any kind of intolerance or allergies to food supplement sources.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-8gd5g8	Educational intervention in the Adherence of the elderly to actions that prevent falls	Recruitment completed	Intervention	2019-12-17	<NULL>	<NULL>	3290	Effect of Educational intervention on Addressing elderly to fall preventive Measures: almost experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-8gd5g8	<NULL>	"Be 60 years and over;
Perform at least one of the physical activities offered by the Elderly Living Center."	To present cognitive and mental difficulty verified through the application of the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-85hgcg	Impact of Shock Wave Therapy on male Sexual Impotence after Prostatectomy	Recruitment completed	Intervention	2017-09-22	<NULL>	<NULL>	3291	Impact of Low-Intensity Extracorporeal Shock Wave Therapy in the treatment of Erectile Dysfunction in patients undergoing Radical Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-25	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-85hgcg	<NULL>	Radical prostatectomy with nerve sparing; Age less than or equal to 75 years; Preserved libido; IIEF-5 of at least 18 (International Index of Erectile Function; stable relationship for at least three months.	uncontrolled diabetes mellitus; hypogonadism; uncontrolled psychiatric condition; pelvic radiotherapy or androgen deprivation therapy; complications in the postoperative period with surgical intervention (Clavien-Dindo&gt; II).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-5ctpcr	Therapeutic effect of red laser to promote relieve of headache	Recruitment completed	Intervention	2019-12-17	<NULL>	<NULL>	3292	Double-blind, crossing over and randomized clinical trial on analgesic effects in migraneous by transcutaneous irradiation in radial artery with 660 nm laser	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-08	Universidade de Araraquara	Universidade de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-5ctpcr	<NULL>	Only participants who meet the criteria required by the International Headache Society for migraine-type headache (CLASS. SIC, 2014); age over 18 years and above 80 years; complain of headache for more than six months and recurrent episodes; report 3 episodes of migraine per month; reported onset of migraine before age 50; have at least 3 months of history and 2-8 attacks per month, with progression of moderate to severe pain symptoms lasting more than 2h; report headache medication use 14 days / month within 3 months prior to study; If they use migraine prophylaxis, you should be stable for 30 days before and throughout the study.	Users of cardiac pacemakers, history of epilepsy, cardiac arrhythmias, being in gestational period; scheduled or undergoing surgical procedures during treatment or 20 days prior to the start of the study; have other primary headache conditions with 15 or more days of pain per month; use opioids for more than 10 days within 30 days prior to screening; have systemic disease or neurological or psychiatric condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5g38dt	Evaluation of metformin effects in patients with primary myelofibrosis, post-polycythemia vera and and post-essential thrombocythemia	Recruiting	Intervention	2019-12-17	<NULL>	<NULL>	3293	Open lable phase II study of metformin activity in patients with primary myelofibrosis, post-polycythemia vera and post-essential thrombocythemia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro de Hematologia e Hemoterapia - Hemocentro (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-5g38dt	<NULL>	Patients over 18 years. Patients who were diagnosed with primary myelofibrosis, post-polycythemia vera and post-essential thombocythemia according to the World Health Organization in 2017, regardless of JAK2 mutation. Patients who are not taking another medication for the treatment of myelofibrosis or who have received treatment for myelofibrosis within 6 weeks prior to study drug initiation. Patients with oral access to the drug. Patients with life expectancy more or equal to 6 months. Palpable spleen measuring 5 cm or more below costal margin. Peripheral blood counts less or equal to 10%. ECOG less or equal to 2. Glomerular filtration rate (GFR) greater or equal to 60mL/min. Adequate liver function (AST or ALT at levels not exceeding 3x the upper limit of normal, total bilirubin at levels not higher than 2x the upper limit of normal). Negative pregnancy test prior to study initiation and agreement on contraceptive use for women of childbearing age.	Patients with known hypersensitivity and / or prior therapy with metformin or its excipients. Diabetes mellitus requiring use of insulin and another oral antidiabetic agent. Human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C (HCV) (except for chronic infections treated or cured for HBV and HCV, which will be accepted). Concomitant use of all herbal supplements during the study (including but not limited to St. John&apos;s wort, kava, None, gingko biloba, dehydroepiandrosterone [DHEA], or ginseng) is prohibited. Megestrol acetate (Megace) or medroxyprogesterone if used as an appetite stimulant is allowed. Uncontrolled conditions due to intercurrent illness, including, but not limited to, ongoing or active infection, refractory systemic hypertension, symptomatic congestive heart failure (New York Heart Association [NYHA] class III functional classification), unstable angina pectoris, cardiac arrhythmia, or psychiatric / social disease that would limit compliance with study requirements. Previous neoplasms, except for skin carcinomas for more than 2 years. Pregnant or breastfeeding patients. Any major surgery, extensive radiotherapy, delayed toxicity chemotherapy, biological therapy, or immunotherapy within 6 weeks prior to clinical trial screening. Any prior or concomitant use of another JAK2 inhibitor. Any investigational medication other than study drug in the 6 weeks prior to the first dose of study drug. Use of hydroxyurea, interferon, prednisone, thalidomide, busulfan, lenalidomide, anagrelide within 6 weeks prior to the first dose of study drug. Hematopoietic growth factor receptor agonists (eg erythropoietin (Epo), granulocyte colony stimulating factor (GCSF), romiplostim, eltrombopag) should not be used as they may be associated with increases in spleen size. Growth factors should not have been used for at least 6 weeks before the first dose of study drug.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-7zhgb3	Comparison of treatment of platelet-rich plasma non-healing wounds in patients with venous abnormalities	Data analysis completed	Intervention	2019-12-17	<NULL>	<NULL>	3294	Comparison of the treatment of chronic ulcers with platelet rich plasma in patients with venous insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7zhgb3	<NULL>	Diagnosis of chronic venous insufficiency; at most 80 years old and minimum of 18 years; ulcer with diameter 10 to 40 cm²	Exclusion criteria will be: base diseases of influence on healing, patients with malignant neoplasia in the last five years, lupus, carriers of ulcers neuropathic or arterial diseases, or any other type of ulcer in the lower limbs that is not related to chronic venous insufficiency; the patients who presented 3 (three) consecutive absences or 6 (six) alternate and the non-consent to participate in the research willingly and spontaneously, Uncontrolled Systemic Arterial Hypertension (SAH), Acquired Immunodeficiency Syndrome (HIV), Anemia, Stroke or Acute Myocardial Infarction (AMI) in the last 3 months, Renal insufficiency (creatinine more than 2 mg / dl), Liver Disease (TGO more than 2x upper limit, INR more than 1.5), surgery or major trauma in the last 2 months, pregnant woman, mental retardation, inclusion in other studies in the last 30 days and relative of first or second degree of another patient in the study group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-35yzss	Evaluation of the effects of maxillary expansion anchored on mini-implants	Recruiting	Intervention	2019-12-17	<NULL>	<NULL>	3295	Evaluation of the effects of rapid maxillary expansion anchored on mini-implants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-35yzss	<NULL>	Skeletal maxillary atresia with indication of maxillary expansion; age between 11 to 15 years; permanent dentition with first premolars completely erupted;  balanced facial profile (straight); good general and dental health.	Presence of periodontal disease; endodontic problem in any upper teeth ; canine, or upper premolar or molar agenesis; previous orthodontic treatment; presence of cleft palates or syndromes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-6pws57	Effects of luting agents on performance of metal free crowns	Recruiting	Intervention	2019-12-18	<NULL>	<NULL>	3296	Effects of gic luting agents on the clinical performance of metal free crowns - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6pws57	<NULL>	Age between 18 and 70 years old, Health adult patient older than 18 years old; Patient requesting two full-crown restorations (both on anterior or both on posterior teeth); Occlusal contact of the tooth to be restored with the antagonist tooth; The selected teeth do not require endodontic treatment our were (or will) be properly endodontically treated before the research treatment; The selected tooth has not structural loss OR have more than ½ of remaining crown structure OR have less than ½ of the crown structure but can be restored after receive intraradicular post; Tooth mobility degree 0 or 1 according to Miller (no mobility or up to 1mm).	Signs of bruxism; Severe periodontal disease on all teeth or on the teeth indicated for treatment; Systemic disease that counter indicate dental treatment; Pregnancy; Allergy to the restorative materials; Selected tooth showing mobility degree 2 or 3 according to Miller; Clinical or radiographic signs of active periapical or bifurcation lesions; Invasion of the biologic width; Root fractures; Tooth with painful symptoms and impossible to treat, being extraction indicated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-43vvkt	Effects of resistance exercise  in elderly with sarcopenia	Recruiting	Intervention	2019-12-18	<NULL>	<NULL>	3297	Effects of resistance exercise  on biochemical, physiological, cognitive and behavioral parameters in elderly with different  sarcopenia levels	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-14	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-43vvkt	<NULL>	individuals of both sexes aged 65 to 80 years old;do not use drugs that induce myopathy or food control;not participate in any regular exercise program in the last 3 months;present medical clearance for physical exercise	"Have physical limitations, or diseases that compromise the practice of physical exercise;to present cardiovascular diseases with associated complications that prevent the practice of physical exercise;present severe psychiatric illness (major depression);present neurological diseases: stroke ,  transient ischemic accident, head injury, Parkinson&apos;s and Alzheimer&apos;s disease; intake of anti-inflammatory drugs, erythropoietin and acetylcholinesterase inhibitors
drug addiction ,alcoholism and illicit drugs
communication and visual impairment that prevent the practice of physical exercise
exhibiting vertigo;any osteomioarticular injury during the intervention period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-6gh6s9	Dietary intervention in metabolic syndrome and its association with the genetic profile of lactose intolerance	Recruiting	Intervention	2019-12-19	<NULL>	<NULL>	3298	Influence of lactose-free diet on metabolic syndrome: role of polymorphisms in the genes for lactase, adiponectin and its receptor, GIP and its receptor, TCF7L2, TNF-alpha, IL-6 and NFK-B	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade do Estado da Bahia	Associação de Pais e Amigos dos Excepcionais (APAE)	https://ensaiosclinicos.gov.br/rg/RBR-6gh6s9	<NULL>	Volunteers diagnosed with metabolic syndrome based on the criteria proposed by the International Diabetes Federation (IDF, 2006); both genders; age range from 20 to 80 years old; signature of the informed consent form (ICF).	Patients with inflammatory bowel disease (Crohn&apos;s disease, ulcerative colitis, irritable colon and diverticulitis); with chronic renal failure; with chronic liver disease (with the exception of hepatic steatosis); taking medication for appetite control, hypoglycemic, hypolipidemic or anxiolytic/antidepressant; with autoimmune diseases and/or taking corticosteroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-3qg2my	Studying the consequences of Chikungunya and increasing the peoples’ quality of life	Recruiting	Observational	2019-12-19	<NULL>	<NULL>	3299	Multicenter study of the natural history and therapeutic responses of patients with Chikungunya, focusing on acute and chronic musculoskeletal manifestations	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)	Departamento de Ciência e Tecnologia do Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3qg2my	<NULL>	"Age equals or more than 18 years; patients with recent fever, less than 10 days, with suspected CHIKV, ZIKV or DENV; patients with arthralgia after having a fever, more than 10 days, with suspected CHIKV, ZIKV
or DENV"	"Patients unavailable to attend follow-up at the centers; presence of overt fever from a supposed non-viral origin (eg, cellulitis and abscess); patients with severe mental disorders or from whom the collection of information is
not possible due to communication disorders or lack of fluency in Portuguese or another
language understood by the attending physician; pregnant or lactating patients"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-72kd57	Effect of impact home based exercises to people with Down syndrome	Data analysis completed	Intervention	2019-12-19	<NULL>	<NULL>	3300	Effect of home based exercises to people with Down syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72kd57	<NULL>	"Have clinical and laboratory diagnosis of DS;Be in follow up in the Rehabilitation Program for people with DS of IMREA HCFMUSP Lucy Montoro;
18 to 35 years old; Preserved mobility;Normal cardiorespiratory test"	"Current heart disease;Atlantoaxial subluxation;
Severe intellectual disability;Orthopedic problems;Neurodegenerative and musculoskeletal diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-2bnc6y	Alternating red and infrared laser photobiomodulation therapy for temporomandibular disorders: study protocol for a randomized double-blind clinical trial	Recruiting	Intervention	2018-04-12	<NULL>	<NULL>	3301	The influence of educational measures and low-level laser phototherapy on temporomandibular disorders: effects on pain, mandibular mobility and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2bnc6y	<NULL>	Participants aged between 18 and 55 years;  diagnosed with myalgia and arthralgia, with or without disc displacement; reporting pain or discomfort related to the TMJ area, greater than 4 cm in a visual analogic scale; literated.	Participants that carry muco-supported dental prostheses, orthopedic or orthodontic appliances; whose state of health contraindicates some of the therapies; who present teeth in severe precarious conditions, as an indication of endodontic treatment; carriers of rheumatoid arthritis; who are using any analgesic or antiinflammatory medication; carriers of congenital problems with involvement of TMJ or orofacial and cervical skull region; with recent mandibular fractures; or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5b6wc3	Effects on breathing, muscles, metabolism and body awareness in Pilates exercises	Recruiting	Intervention	2019-12-26	<NULL>	<NULL>	3302	Respiratory, muscular, metabolic effects and body perception of a Pilates protocol: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-12	Universidade Federal de Alfenas - Unidade II	Clínica Vital Pilates	https://ensaiosclinicos.gov.br/rg/RBR-5b6wc3	<NULL>	Healthy individuals; age range between 18 and 44 years old; women; willing to participate in the study.	Severe pathologies of the spine; fibromyalgia; intellectual disability; inability to provide consistent information; practice of PM until 6 months before the study; pregnancy; puerperium up to 6 months; vestibular disorders that may interfere with balance; use of continuous medication for pain or inflammation; obesity greater than 30 kg / cm2; be conducting other fitness programs; practice of functional physical activity; neurological diseases; cardiovascular diseases; severe respiratory diseases; any other condition in which exercise is contraindicated; who do not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-3rvfwt	Effect of combination therapy with Noninvasive Brain Stimulation and Gamotherapy in patients with Parkinson&apos;s Disease	Data analysis completed	Intervention	2019-12-26	<NULL>	<NULL>	3303	Effect analysis of combined therapy with repetitive Transcranial Magnetic Stimulation (rTMS) and gametherapy on motor and cognitive functional capacity of individuals with PD	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal da Paraíba-	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3rvfwt	<NULL>	The study included individuals with clinical diagnosis of PD, of both sexes, with clinical diagnosis of PD, with staging of PD between 1 and 3 on the Hoehn and Modified Yahr scale, who are assisted by SUS, and who agree to participate in the study.	Excluded from this study were: Individuals with PD associated with another chronic neurodegenerative disease; diagnosed with parkinsonian syndrome; individuals with a history of epilepsy; carriers of another disabling condition; and to participate in other physical therapy interventions; have previous experience with Kinect; individuals with functional deficit that makes it impossible to perform the practice proposed by Kinect.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-47pnrf	Thrombosis biomarkers after varicose vein treatment using foam injection and conventional surgery	Recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3304	Peripheral blood thrombosis biomarkers after great saphenous vein reflux treatment using polidocanol foam chemical ablation and conventional saphenectomy	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-47pnrf	<NULL>	Symptomatic varicose veins; age 18-80 years; great saphenous veins total or partial reflux in one or both limbs, detected by duplex ultrasound.	Significant active comorbidity; infectious disease (infected ulcer); thrombophilia; previous tromboembolic event; anticoagulant or antiplatelet use; pregnancy; increased cardiovascular risk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-3b2g2y	Different semantic frequencies of pelvic floor muscle training for women with stress urinary incontinence	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3305	Different weekly frequencies of pelvic floor muscle training for women with stress urinary incontinence: a ramdomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de São Carlos	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3b2g2y	<NULL>	Being a woman (biological); Age 18 years and over; complain of stress urinary incontinence determined by the affirmative response to involuntary urine loss associated with coughing, sneezing, exercise or weight lifting in the last month.	Latex allergy; vaginal or urinary tract infection; virginity; being in the gestational period; being in the puerperal period; complain of neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-66nq5z	Prevention of skin lesions due to positioning during surgery	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3306	Prevention of skin lesions by surgical positioning: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação strictu sensu em Atenção à Saúde	https://ensaiosclinicos.gov.br/rg/RBR-66nq5z	<NULL>	Patients who are in preoperative elective surgery, lasting longer than 120 minutes and supine dorsal position.	Patients who present skin lesion in the preoperative evaluation; patients unable to measure weight and height; local anesthesia; ASA IV and V and / or have limb amputation; change in decubitus during the surgical procedure or intraoperative complications (death or severe hypotension).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5q5t5z	Effects of lavender essential oil on sleep in postmenopausal women with insomnia	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3307	Effects of lavender essential oil inhalation on sleep quality in postmenopausal women with insomnia	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-04-24	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5q5t5z	<NULL>	Postmenopausal women between 48 and 65 years old; Hysterectomized and / or oophorectomized  women with follicle stimulating hormone (FSH) concentrations 30 mUl / mL; They haven&apos;t used hormone therapy in the last 3 months; They haven&apos;t used sleep medications in the last month; Stop-Bang questionnaire with score &lt;3; Clinical diagnosis of insomnia	Diagnosis of uncontrolled clinical diseases; History of serious neurological or psychiatric disorders; In treatment for insomnia or for complaints of postmenopausal symptoms; In drug treatment with the use of benzodiazepines, antihistamines, hypnotics, hypnotic phytotherapics, sedatives, antidepressants, antipsychotics, stimulants (amphetamine, caffeine, modafinil), corticosteroids; They have previously received aromatherapy treatment; They have been practice meditation or yoga for sleep problems; If they will presente repulsion to the odor of Lavandula angustifolia essential oil or sunflower oil; Workers in shift; Illiteracy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5jm6gw	Evaluation of gynecological and dermatological acceptability of health product under normal use, with PH measurement	Not yet recruiting	Observational	2019-12-05	<NULL>	<NULL>	3308	Evaluation of gynecological and dermatological acceptability of health product under normal use, with measurement of PH, microbiota and Swab collection	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-5jm6gw	<NULL>	Women; Age 18 to 65 years; Phototype I to IV; Whole skin of the region; Occasional user of category products	"Skin markings in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn);
Pregnant or lactating women;
Participants with a history of allergy to the material used in the study;
History of atopy;
Use of vaginal cream;
Participants with a history of allergy to products of the tested category;
Recent gynecological surgeries;
Discharge;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis)
o Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-95n4vs	Clinical simulation and effects on nursing students	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3309	Clinical simulation of cardiorespiratory and cerebral arrest in adults: evaluation with undergraduate nursing students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade da integração Internacional da Lusofonia AfroBrasileira	Universidade da integração Internacional da Lusofonia AfroBrasileira	https://ensaiosclinicos.gov.br/rg/RBR-95n4vs	<NULL>	Student regularly enrolled in the seventh and ninth undergraduate who have attended and passed the Adult Health discipline.	Previous Emergency Experience	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8gpgyd	Teleconsultation study in diabetic patients	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3310	Pragmatic, unicentric, open-label, phase 2, non-inferiority, randomized controlled trial to evaluate the efficacy and safety of teleconsultation compared to face-to-face consultation of patients with Diabetes Mellitus referred from primary care to specialized care in the single health system	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Alemão Oswaldo Cruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8gpgyd	<NULL>	Adult patients, both sexes, older than 18 years; diabetic patients, regardless of priority, according to the protocol defined in the study; patients diagnosed with type 2 diabetes mellitus, with any level of glycemic control measured by glycated hemoglobin and/or fasting glucose, who meet criteria for referral from primary care to specialized care; patients on insulin with glycated hemoglobin greater than 8	Patients under 18 years of age and Type 1 diabetes mellitus; patients with gestational diabetes mellitus or diagnosed during pregnancy; Patients with estimated or measured creatinine clearance below 30 ml / min / m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-72v646	Monitoring of finger blood flow in patients who have developed a worsening of renal function due to a generalized infection	Recruiting	Observational	2019-12-27	<NULL>	<NULL>	3311	Monitoring peripheral perfusion in Sepsis associated acute kidney injury: prognostic, temporal evolution and fluid balance analysis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Hospital das clínicas da Ufpr	Hospital das clínicas da Ufpr	https://ensaiosclinicos.gov.br/rg/RBR-72v646	<NULL>	Sepsis patients	"Pregnance; Dialitic Cronic kidney injury; Not avalible peripheral perfusion; 
Patient refusal"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-2p44j7	Laser and Microcurrent in Pressure Ulcers.	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3312	Effects of Laser Therapy and Microcurrent on Pressure Ulcer healing process: a randomized double blind placebo study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-2p44j7	<NULL>	Individuals of both sexes aged 18 years and over; One or more pressure injuries; Have signed the Informed Consent Form (ICF).	Not performing any other therapy that may interfere with the healing process, such as chemotherapy, radiotherapy, or corticotherapy; Severe diseases such as severe liver, heart or kidney disease; Arrhythmia heart disease using cardiac pacemaker; Patients using a metal implant near the treatment site; Deep vein disease, thrombophlebitis; Pain of central or unknown origin; Active osteomyelitis; Active carcinoma; High hypersensitivity and thrombosis in pelvic vein or deep leg veins;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-7k7w3d	Chinese herbal medicine to reduce occupational stress in nursing: Randomized clinical trial	Recruitment completed	Intervention	2019-12-27	<NULL>	<NULL>	3313	Chinese herbal medicine to reduce occupational stress in nursing: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Escola de Enfermagem da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo - FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-7k7w3d	<NULL>	Women in the morning or afternoon shift; aged 20 to 50 years; classified by the Vasconcellos Stress Symptom List (LSS) with medium or high stress of 37 to 119 points and sleep fully in the dark. Will be part of the research those who voluntarily want to participate, sign the informed consent and are available for data collection.	Those with gluten intolerance will be excluded, as one of the components of the GMDZ herbal medicine is wheat. Pregnant women will also be excluded; smokers; taking glucocorticoids in the last three months; HPA-influencing drugs such as beta-blockers, glucocorticoids, antidepressants, and psychoactive drugs; employees with less than one year of work at the institution, with vacations scheduled during the research period; who are on sick leave; make use of anxiolytics and antidepressants; those who use other complementary therapy (acupuncture, herbal medicine, reiki, flower therapy, among others). Those who were already using other allopathic medicines or who were already undergoing psychological therapy will not be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8wjq29	Evaluation of Isoniazid 300 mg Drug for the Treatment of Latent Tuberculosis Infection in Brazil	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3314	Evaluation of Isoniazid 300 mg Implementation for the Treatment of Latent Tuberculosis Infection in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-8wjq29	<NULL>	Patients who agree with the consent form; Patients of both sexes; Indication for treatment with isoniazid 300mg per day; With access to mobile smartphone with Android operating system; patients who know or not read; age between 18 and 50 years;	Patients on treatment for rifampicin or already on treatment for latent tuberculosis; patients with HIV; pregnant or intending to become pregnant; homeless patients; deprived of liberty; Patients referred for treatment over 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-79dn4k	Effect of a program on drug use in patients with Ulcerative Colitis	Recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3315	Impact of an intervention program on nonadherence to drugs in Ulcerative Colitis Patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado da Bahia	Programa de Pós-Graduação em Ciências Farmacêuticas - PPGFARMA	https://ensaiosclinicos.gov.br/rg/RBR-79dn4k	<NULL>	Patients diagnosed with ulcerative colitis (UC); at least 3 months of active registration in the Farmácia Integrada do Medicamento na Atenção Especializada(FIMAE); prescribed with at least 01 medicine to treat UC; of the same age or over 18 years; able to respond to the research tools; agrees to sign the Informed Consent Form (TCLE); assisted by outpatient clinics of Inflammatory Bowel Disease (IBD) at the Hospital Geral Roberto Santos(HGRS) or Hospital Universitário Professor Edgard Santos HUPES); owns a cell phone.	Patients classified as adherents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8ym9yj	Improvement in the quality of surgeon&apos;s hand preparation to prevent Surgical Site Infection in cardiac, thoracic and orthopedic surgeries.	Data analysis completed	Intervention	2020-01-02	<NULL>	<NULL>	3316	Promoting quality of Surgical Hand Preparation with Alcohol Solution for prevention of Surgical Site Infection in thoracic, cardiac and orthopedic surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	World Health Organization Implementation Research Regional Training Centre for the Americas’ Region	https://ensaiosclinicos.gov.br/rg/RBR-8ym9yj	<NULL>	Being a surgeon of cardiac  and orthopedic teams working in the study hospital	Do not participate in any surgical procedure in one of the study stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-48rxwb	Efficacy of SGLT2 inhibitor for Non-Alcoholic Fatty Liver Disease	Recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3317	Evaluation of the efficacy of SGLT2 inhibitor for Non-alcoholic Fatty Liver Disease in diabetics and non-diabetics: clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-11-01	Centro Educacional Hyarte	Centro Educacional Hyarte	https://ensaiosclinicos.gov.br/rg/RBR-48rxwb	<NULL>	"Patients older than 20 years who present alterations in transaminases with cutoff above 35 U / l and hepatic fat content above 7.5% by MRI will be included. 
Diabetic patients will include those with a disease duration of more than 6 months (under treatment) and less than 10 years; without the use of insulin therapy and using at maximum two oral antihyperglycaemic agents"	The exclusion criteria will be: alcohol use more than 30 grams / day over 10 years for men and more than 20 grams / day for women; viral hepatitis B and C and HIV; drugs that impair beta oxidation (methotrexate, amiodarone, tetracycline, tamoxifen, chemotherapeutics); autoimmune hepatitis; biliary diseases; metabolic genetic disorders; ferritin above 1000 mg / dL; recurrent urinary tract infection; diabetics using GLP-1 analogs or in oral double therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-4pjt82	Influence of microphone directionality and control of the amount of electric current level on speech perception and frequency discrimination in cochlear implant users	Recruitment completed	Intervention	2020-01-02	<NULL>	<NULL>	3318	"Influence of microphone directionality and modulation of duration of electrical pulse in speech perception and discrimination
of pitch in cochlear implant users"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-07	Obras Sociais Irmã Dulce	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4pjt82	<NULL>	Age 18 years and over; bilateral severe and / or deep sensorineural hearing loss; hearing loss of postlingual origin; limited benefit with the use of hearing aids (sentence recognition threshold below 50% in the best ear with amplification); first cochlear implant surgery; absence of anatomical contraindications; fluency in Portuguese (Brazil), including reading and writing; signature of the Informed Consent Form.	Partial insertion of the electrodes in the cochlea (more than four electrodes out of the cochlea); patients who were in a closed set (ie, could not have any speech recognition without visual cues) at the time of the speech tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-2s4tpw	Effects of phototherapy on pressure ulcers	Not yet recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3319	Effects of photobiomodulation on pressure injury stages 2 and 3 clinical controlled randomized blinded study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	São Paulo Secretaria da Saúde	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2s4tpw	<NULL>	Participants over 18 years. Both sexes. With pressure injury stages 2 or 3. Length of stay 15 days.	Participants with active neoplasms or palliative care; osteomyelitis in the wound region or with stage 1 or 4 pressure injuries. Deep tissue injury; unclassifiable lesions; complex wounds, necrotic; infected  will be excluded. Patients with a history of photosensitivity to photonic therapy or who have significant neurological or psychiatric disorders will also be excluded from the study as it compromises assessments of uncoupling or pain during photobiomodulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-5hh9q5	Comparison between tibial nerve stimulation and  vaginal stimulation to treat urinary loss in elderly women	Data analysis completed	Intervention	2019-11-28	<NULL>	<NULL>	3320	Comparison between Transcutaneous Tibial Nerve Eletrical Stimulation and Transvaginal Eletrical Stimulation to treat Urge Urinary Incontinence in elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5hh9q5	<NULL>	Women; with 60 years old or more; complaining of urgency urinary incontinence; assisted at the Clinic of Urogynecology at Hospital São Lucas da Pucrs.	Patient complaining of stress urinary incontinence exclusively; genital prolapse above the second stage of the POP-Q classification; patients with pacemakers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3pdqt5	Effect of cinnamon intake on cardiovascular risk factors in elderly	Recruitment completed	Intervention	2016-08-08	<NULL>	<NULL>	3321	Effect of cinnamon (Cinnamomum sp) intake on metabolic syndrome and its components in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Pontifícia Universidade Católica do Rio Grande do Sul - Pucrs	Universidade Regional Integrada do Alto Uruguai e das Missões - campus Erechim (Uri-Erechim)	https://ensaiosclinicos.gov.br/rg/RBR-3pdqt5	<NULL>	60 years or older; patients diagnosed with metabolic syndrome; participate of social groups in Erechim, Rio Grande do Sul, Brazil.	Be under nutritional treatment; use or change the dose of lipid-lowering drugs, antihypertensive and hypoglycemic less than three months; be patient with insulin dependent diabetes; alcoholic (alcohol abuse present above 30g ethanol/day); be patient with chronic renal failure, with serum creatinine levels above 1.4 mg/dL; be patient with swallowing disorders; be patient with esophagitis, gastritis and duodenitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4qhkf4	Effects of Sildenafil on exercise breath in subjects with mild to moderate COPD	Recruiting	Intervention	2018-11-30	<NULL>	<NULL>	3322	Effect of Sildenafil on mechanical ventilation, mechanical ventilation and dyspnea during exercise with mild to moderate COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal do Rio Grande do Sul	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4qhkf4	<NULL>	The sample eligible for the study will consist of volunteers with a previous diagnosis of COPD; both genders; GOLD I or II; clinical stability; no signs of exacerbation in the eight weeks prior to the study; capable of performing bicycle exercise testing; sign the Informed Consent Form.	Individuals with associated diseases that may compromise exercise performance; use of oxygen therapy; SpO2 less than 85% at rest in ambient air; receiving chronic or eventual nitrate therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-38f87m	Problem behaviors in childhood: study of measures and proposal of an intervention program with mothers	Recruitment completed	Intervention	2020-01-03	<NULL>	<NULL>	3323	Antisocial behavior in childhood: psycometric properties of measures and proposal for a mother intervention program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-38f87m	<NULL>	The criteria for inclusion of participants in the respective groups are: having a child who has presented behavioral problems in the last six month;  having a child with characteristics of antisocial behavior in the age group of 3 to 7 years; the mother is willing to participate weekly in the intervention group; the mother reside with the child.	Exclusion criteria are: mothers have psychiatric disorders, such as mental retardation, invasive developmental disorders or cognitive developmental delay, which impairs the understanding of instructions; mothers or children are in therapeutic follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-2c9tcq	Strength, blood pressure and blood glucose levels in various groups	Data analysis completed	Observational	2020-01-03	<NULL>	<NULL>	3324	"Effects of different levels of resistance training intensity in relation to the
physical, hemodynamic and glycemic capacities of different groups"	<NULL>	0, n/a, n/a	0	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2c9tcq	<NULL>	TTo be included in the study participants are 60 years or older; participate in regular recreational activities twice a week; do not participate in structured resistance training for less than six months prior to the commencement of the study;present a medical certificate on the project application.	To be included in the final analyzes; participants had to perform 80% of all training sessions; participate in the collections before and after the training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4xgwxb	A pilot study for care for trans men	Not yet recruiting	Observational	2020-01-03	<NULL>	<NULL>	3325	Humanization of trans men`s care: A pilot study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Mauro Schechter	Projeto Praça Onze	https://ensaiosclinicos.gov.br/rg/RBR-4xgwxb	<NULL>	female gender (at birth); Able to provide written informed consent;Aged 18 to 65 years older; Identify with the male Use of masculinizing hormones	male gender at birth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3z3qd6	Effectiveness of TENS in vocal therapy of women with vocal disorders	Data analysis completed	Intervention	2020-01-03	<NULL>	<NULL>	3326	The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in vocal therapy of dysphonic women: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3qd6	<NULL>	complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	volunteers who had received speech therapy before;  over 45 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6vbsmb	Clinical efficacy of distance exercises associated with professional telephone follow-up for patients with neck pain	Not yet recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3327	Effect of a telerehabilitation exercise protocol in subjects with chronic neck pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6vbsmb	<NULL>	Participants between the ages of 18 and 65 years, neck pain for at least 3 months, with or without radiating pain, no history of significant injury to the neck or upper thoracic spine (car accident), experiencing pain during the physical exam.	Patients will be excluded if they had undergone cervical spine surgery or cervical spine stenosis, reported neurological signs, severe pain (&gt;7/10) during muscle strength measurements, rheumatic and/or inflammatory diseases (ankylosing spondylitis, rheumatoid arthreitis), cervical instability, spinal cord involvement or congenital diseases affecting the musculoskeletal system, major psychological disease (severe depression or mental disorder), pregnancy, and any intervention that included exercise or physical therapy in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4z5bxd	The effect of mirror therapy associated with electrical stimulation on the patient&apos;s arm function after stroke	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3328	The effect of mirror therapy associated with electrostimulation on patient upper limb functionality after stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-31	Universidade de Guarulhos	Universidade de Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-4z5bxd	<NULL>	"Patients over the age of 40 years;
Patients diagnosed with stroke for at least one year;
Possess upper limb sequelae;
Absence of musculoskeletal deformities;
Be able to perform the test exercises;
Not afraid of performing electrostimulation."	"Children;
Have plegia in the upper limbs;
Unable to perform the test exercises;
Shoulder injury;
Lower limb sequelae;
Not being available to perform the search."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7pjmj4	Effect of microcurrent on the tooth movement	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3329	Effect of Low-Intensity Electrical Current on orthodontic movement acceleration and pain perception	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-14	Fundação Hermínio Ometto	Fundação Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-7pjmj4	<NULL>	Adults with permanent dentition; caries free dentition and healthy periodontal structure; the presence of moderate to severe crowding in the anteroinferior region of the arches; non-concomitant use of analgesics and anti-inflammatories; voluntary participation in the study confirmed by the signature of the informed consent form.	Patients with missing teeth in the anterior-inferior region of the right premolar to the left premolar; individuals who present chronic or not chronic orofacial pain; patients whose informed consent was not obtained, patients in mixed dentition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3q4v5z	In hospital cardiac rehabilitation after acute myocardial infarction	Recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3330	Effects of an early-progressing cardiac rehabilitation program in hospitalized patients after acute myocardial infarction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-19	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-3q4v5z	<NULL>	Inclusion criteria will be: individuals of both sexes, aged eighteen or older, diagnosed with ST-segment elevation acute myocardial infarction with clinical and hemodynamic stability.	Exclusion criteria will be: hemodynamic instability; AMI with Killip Classification III and IV; angina after AMI; refractory hypertension with levels above 180X110 mmHg, malignant ventricular arrhythmias; inability to perform assessment or protocol for cognitive and / or neuromusculoskeletal causes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6cywff	Effects of the resistance exercise on muscle and vascular function in older adults with reduction of muscle strength and mass.	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3331	Effects of a low-intensity resistance exercise program with vascular occlusion on muscle function and microcirculation in older people with Sarcopenia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)	Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)	https://ensaiosclinicos.gov.br/rg/RBR-6cywff	<NULL>	Age 65 to 100 years without regular physical activity for at least six months with sarcopenia.	Muscle problems; cardiovascular diseases; obesity; smoking; cancer; diabetes mellitus; autoimmune diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-9zn52b	"Effect of hydrotherapy compared with decongestive complex therapy for reduction of
lymphedema in lower limb"	Recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3332	"Effect of hydrotherapy compared with decongestive complex therapy for reduction of
lymphedema in lower limb"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de fisioterapia da Universidade Federal de Pernambuco	Faculdade de fisioterapia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9zn52b	<NULL>	Lower limb lymphedema	Use of topical antifungal and prophylactic antibiotics for secondary infections; infectious processes active and not treated during the project; thrombophlebitis; active neoplasms at the site of drainage, cellulitis, deep venous thrombosis in the acute phase, cardiac, hepatic and renal decompensations, and uncontrolled hypertension; significant lower limb arteriopathies and neoplastic degeneration of lymphedema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-9th6k4	Impact That Light Forces And Heavy Forces Generated By Orthodontic Appliances May Cause In Resorption Of The Roots Of Deciduous Teeth	Recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3333	Impact of orthodontic and orthopedic forces in the radicular resorption of deciduous teeth	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-21	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9th6k4	<NULL>	Inclusion criteria common to all groups: children about 9 years of age with intact primary canines and molars; without prior orthodontic interventions; with preventive / interceptive orthodontic needs or space supervision. Participants may not have chronic or systemic diseases that affect dental resorption or formation.	Exclusion criteria: patients with chronic or systemic diseases that affect dental resorption or formation, participants with previous orthodontic treatment, because the pattern of dental resorption may be altered and / or participants with exfoliated canines or primary molars.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4nj4db	General anesthesia with or without thoracic infiltration of anesthestics. How can we improve the quality of postoperative recovery of breast cancer surgeries	Data analysis completed	Intervention	2020-01-06	<NULL>	<NULL>	3334	General anesthesia with or without thoracic wall blocks. How can we improve the quality of postoperative recovery of breast cancer surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-04	Faculdade de ciências médicas da universidade estadual de campinas	Faculdade de ciências médicas da universidade estadual de campinas	https://ensaiosclinicos.gov.br/rg/RBR-4nj4db	<NULL>	Patients under 18 and 85 years old; elective oncologic breast surgeries, ASA score 1,2,3 ; able to comprehend and respond questions and the Numerical pain scale.	patient refuse; hipersensibility of anesthetics; anatomic impossibility to do the blocks;difficult airway; unable to complete the questions; contraindications of regional anesthesia (coagulopathy, infections on the site of the blocks).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-24y9dd	Arthrocentesis vs nonsurgical methods in the treatment of temporomandibular joint pain and closed lock. A randomized controlled trial	Recruitment completed	Intervention	2020-01-06	<NULL>	<NULL>	3335	Does the association of Nsaids whit arthrocentesis for 30 days improve the mouth opening and painfull symptoms in temporomandibular joint dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Faculdade de Odontologia da Universidade Estadual do Rio de Janeiro	Faculdade de Odontologia da Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-24y9dd	<NULL>	Patients older than 18 years and younger than 67; presenting at least 4 points corresponding to joint pain in the visual analogue scale (VAS); with mouth opening  at less or equal than to 35 mm; with a history of joint locking;  progressive decrease of mouth opening and joint noises	History of TMJ surgery or with an absolute indication of surgical treatment; joint systemic diseases; gastric disease or other condition that contraindicate the use of NSAIDs; muscular pain as the main source of the symptomatology and patients with psychological compromises that would make treatment impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7q6g5b	Feeding of children and adolescents with Atopic dermatitis and disease severity	Recruiting	Observational	2020-01-07	<NULL>	<NULL>	3336	Food intake of children and adolescents with atopic Dermatitis and its relationship with disease severity	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Engenharia de Alimentos da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7q6g5b	<NULL>	Will be included all children and adolescents between 1 and 17 years and 11 months of age already diagnosed with atopic dermatitis and attended at the Unicamp Hospital Dermatology Ambulatory.	Exclusion criteria will be disagreement with the research and lack of signature of the Ethics Committee Terms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-8w9rzy	Comparison between Radioembolization and Transarterial chemoembolization in liver cancer treatment	Recruiting	Intervention	2020-01-07	<NULL>	<NULL>	3337	Comparison between Radioembolization with 131I-Lipiodol and Transarterial chemoembolization in Hepatocellular carcinoma treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Faculdade de Medicina de Botucatu/ Universidade Estadual Paulista	Faculdade de Medicina de Botucatu/ Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8w9rzy	<NULL>	Age of 18 years-old or older; hepatocellular carcinoma graded as intermediate or advanced; liver cirrhosis; performance status of 0 or 1 at the time of the treatment; with contrast-administrated imaging exams before the treatment to assess the treatment response.	Another neoplastic disease; incomplete study procedures; lack of imaging exams during the follow-up; other severe ilnesses in advanced stage that could be more harmful to the patient survival than the hepatocellular carcinoma and the liver cirrhosis, such as chronic obstructive pulmonar disease, cardiac insuficiency, immunosupression (caused by HIV infection or drug-induced) or dialytic kidney insuficiency; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6qw5sp	Changes in heart rate and immediate blood pressure and after different protocols of breathing exercises in patients with Chagas&apos; heart disease.	Recruitment completed	Intervention	2020-01-07	<NULL>	<NULL>	3338	Acute and subacute hemodynamic changes in individuals with chronic chagasic cardiopathy submitted to different respiratory muscular training protocols - Clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-6qw5sp	<NULL>	Male and female gender; be over 18 years old; having stage B2 and C chagasic heart disease; be in regular follow-up at the Chagas disease outpatient clinic of the Evandro Chagas National Institute of Infectious Diseases (INI).	Clinically decompensated individuals; who have chronic lung disease; who have atrial fibrillation; pacemaker carriers; who present some clinical limitation that contraindicates the performance of the proposed exercise protocol; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7thswq	Effects of Vagus Nerve Electric Stimulation  upon the autonomic nervous system, cardiac function and inflammation in patients with the Metabolic Syndrome	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	3339	Effects of Vagus Nerve Transcutaneous Electric Stimulation on autonomic, hemodynamic and inflammatory markers in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Nove de Julho-UNINOVE	Universidade Nove de Julho-UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7thswq	<NULL>	"Elected individuals met all the criteria listed below:
Diagnosis of Metabolic Syndrome based on newly established criteria - three abnormal findings out of five qualify a person for the diagnosis of Metabolic Syndrome:
Waist circumferential increase ( equal to or greater than 102cm in men; equal to or greater than 88cm in women);
Increased triglycerides (equal to or higher 150 mg/dL);
Reduced HDL-C (equal to or less than 40mg/dL in men; equal to or less than 50mg/dL in women);
Increased blood pressure (systolic equal to or higher 130mmHg); and/or diastolic equal to or higher 85mm Hg);
High fasting blood glucose (equal to or higher 100mg / dL);
Patient declaration of stable weight and diet for at least six months until study entry;
Normal renal function;
Normal thyroid function;
Able to declare written consent and compliance with study taxation along the study."	"Subjects were not eligible to participate in the study if they met any of the exclusion criteria listed below:
On antidiabetic medication or with HbA1c greater than 8.0%;
Triglyceride levels equal or greater than 400mg / dL or on lipid-lowering medication;
Serum alanine transaminase (AST) and / or aspartate transaminase (ALT) levels higher than 200U / L;
Resting systolic pressure greater than or equal to 160 mm Hg; resting diastolic pressure greater than or equal to 100 mm Hg;
Using antihypertensive drugs that interfere (beta blockers) with HRV;
History of debilitating chronic diseases;
Pregnancy;
Volunteers presenting any active neoplasm; cutaneous lesion and / or sensitivity deficit of the left auricle; being on radiotherapy and / or chemotherapy and immunosuppressive treatment, patients with chronic infectious diseases (including hepatitis, Acquired Immunodeficiency Syndrome)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-36fvws	Effects of two types of respiratory muscle training on respiratory strength in bypass patients	Recruitment completed	Intervention	2020-01-07	<NULL>	<NULL>	3340	Effects of two types of Inspiratory Muscle Training on respiratory strength in patients undergoing Myocardial Revascularization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade Nobre	Instituto Nobre de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-36fvws	<NULL>	Using as inclusion criteria an individual of both sexes, aged 18 years or older and submitted to myocardial revascularization procedure via median sternotomy and cardiopulmonary bypass.	Exclusion criteria were patients who did not understand how to perform the techniques, who had hemodynamic instability during the assessment of maximal inspiratory pressure, who had some physical limitation that made it difficult to perform the devices, which remain in the Intensive Care Unit (ICU) for more than 4 days, those who require Invasive Mechanical Ventilation for more than 24 hours and who do not accept to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-24d94j	Music in Pain Relief After Leg Fracture Surgery	Recruitment completed	Intervention	2020-01-09	<NULL>	<NULL>	3341	Music in postoperative pain relief of tibial fracture surgery: clinical trial	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-24d94j	<NULL>	Patients aged 18 years and over and under 60; immediate postoperative period of surgical treatment of exposed tibial fracture and submitted to spinal anesthesia; who had no associated fractures; who had not been on central nervous system depressant drugs for 12 hours; had no reports of allergy to standard institution analgesia.	Present a history of chronic pain; impaired verbal communication; altered hearing acuity; dislike music or that it does not bring good feelings; those who were using another non-pharmacological pain relief method or did not understand pain assessment tools.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-8t5p7d	"Exercises of the Mat Pilates Method: efects 
on posture and postural control in children"	Recruitment completed	Intervention	2017-07-03	<NULL>	<NULL>	3342	Exercises of the Mat Pilates Method: efects on alignment and postural control in healthy children	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-25	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-8t5p7d	<NULL>	Inclusion criteria will be children aged eight to 12 years; not having prior knowledge of the Pilates Method; availability of time for study participation; not performing or participating in an exercise program in the last six months, in addition to physical education at school; be resident in Londrina or region; be healthy and with typical development; consent of the parents or guardians through the signing of the free and informed term.	Children with chronic diseases will be excluded; musculoskeletal involvement of the spine, upper and lower limbs; previous surgeries or that may interfere with the evaluated aspects; inability to maintain orthostatic position; with physical and / or sensorial deficit; complaint of dizziness or vertigo; attention deficit or comprehension; use of continuous medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6hxb9x	Evaluattion of the effectiveness os a motivational application for oral hygiene in adolescents in orthodontic treatment: pilot study	Recruitment completed	Intervention	2020-01-09	<NULL>	<NULL>	3343	Effects of an intervention delivered by an application for increase acceptability of effective oral hygiene instructions in microbioty of young patients under orthodontic treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Coordenação de Aperfeiçoamento Pessoal de Nível Superior	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6hxb9x	<NULL>	Age between 14 and 19 years of both sexes; have a cell phone; treatment with fixed orthodontic appliance; exclusive presence of permanent dentition and who accepted to participate voluntarily through the Consent Form.	previous orthodontic treatment; presence of anterior pathology or disease related to pain; chronic use of analgesic medication and the presence of syndromes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3csg3j	Horizontal and vertical bone augmentations with guided bone regeneration in reduced alveolar bone: a retrospective observational clinical study	Recruitment completed	Observational	2020-01-09	<NULL>	<NULL>	3344	Horizontal and vertical bone augmentations in atrophic alveolar rims with guided bone regeneration: a retrospective observational clinical study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3csg3j	<NULL>	Patients with a horizontal and/or vertical bone deficiency of partially edentulous alveolar ridges that prevented implant installation; good systemic health; capable of maintaining good oral hygiene.	Smokers; excessive alcohol consumption; use of illicit drugs; diabetics uncontrolled systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-5h8z7h	Cosmetic Acupuntura for reduction facial wrinkles	Data analysis completed	Intervention	2020-01-09	<NULL>	<NULL>	3345	"Acupuncture applied to facial aesthetics for
wrinkles of expression: clinical trial"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-02-10	Cristiane Garcia sanchez	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5h8z7h	<NULL>	women; aged between 40 and 64 years; wrinkles  grade II or III by the Glogau scale.	facial esthetic surgery; application of Botox, laser in the last six months; lesions on the face, pregnant women, in use of anticoagulant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-8cdy6v	Efficacy of anti-inflammatory association in postoperative discomfort control: randomized controlled trial	Recruitment completed	Intervention	2020-01-09	<NULL>	<NULL>	3346	Efficacy of Ibuprofen with Arginine co-administered with dexamethasone in the control of pain, trismus and postoperative edema in third molar surgeries: a randomized triple blind trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	UFPE- Universidade Federal de Pernambuco	UFPE- Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8cdy6v	<NULL>	Patients between the ages of 18 and 45 years, healthy, who did not present systemic alterations nor made continuous use of medications, that did not report reactions or processes allergic to the drugs used in the research. The third mandibular third molars should be present at the same angulation, mesioangular, distoangular, vertical or horizontal, (Figure 1), with similar root formation, in addition to the same degree of inclusion in relation to the classification of Pell and Gregory (Figures 2) . The teeth should be included or semi-included, ie completely erupted teeth were not included. To be included in the research the patient should be free of pericoronitis in the last 30 days before surgery, and the region without phlogistic signs.	Do not agree to participate in the research after reading the free and informed consent form; Do not fit the planning of surgical and anesthetic techniques; Do not return to the second surgery (surgery on the opposite side); Use other medications in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7n274y	The influence of elastic Bandaging on the electrical activity and temperature of the quadriceps muscle	Recruitment completed	Intervention	2020-01-09	<NULL>	<NULL>	3347	The influence of Kinesiotaping on the electromiographic activity and temperature of the quadriceps muscle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-25	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7n274y	<NULL>	Inclusion criteria were considered: Healthy individuals, with ages ranging from 18 to 35 years, male, who were willing to participate in the study.	Exclusion criteria were: presence of allergy or hypersensitivity to Kinesiotaping or tape, presence of acute or chronic lower limb injury, gait impairment and inability to walk, or who did not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-9qm2y5	Needle-less anesthesia compared to conventional: clinical trial	Data analysis completed	Intervention	2020-01-09	<NULL>	<NULL>	3348	Comparative Analysis between the Atraumatic and Conventional Anesthetic Technique in Third Molar Removal Surgery:Randomized Clinical Trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-04-01	CESMAC- Centro de Ensino Superior  Maceió	CESMAC- Centro de Ensino Superior  Maceió	https://ensaiosclinicos.gov.br/rg/RBR-9qm2y5	<NULL>	Patients of both genders, systemically healthy, aged between 18 and 45 years and need to remove the contralateral third molars, which were in symmetrical position.	Patients with a history of anesthesia or vasoconstrictor allergy employed, with third molars in non-symmetrical position or who had used anti-inflammatory, analgesic or antidepressant prior to surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6psb2c	Hilotherm® application compared to conventional cold compresses after removal of wisdom teeth	Recruitment completed	Intervention	2020-01-10	<NULL>	<NULL>	3349	"Application of Hilotherm compared to conventional cold compresses in the
postoperative control of third molar extraction"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-26	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-6psb2c	<NULL>	Patients with surgical indication for third molar extraction; Patients who present similarity in degree of impaction bilaterally; Patients who sign the consent form. Patients aged 16 - 40 years were selected for the study.	Patient with a history of cold sensitivity or intolerance, such as Raynaud&apos;s phenomenon; Patient with liver disease, blood dyscrasias, previous or present gastric ulcers, heart disease, chronic pain syndrome, metabolic disorders, central nervous system, immune system or patients with hypersensitivity, drug reaction allergies; Female patients if they are pregnant or nursing; Patient on anti-inflammatory drugs, corticosteroids, antibiotics, lithium therapy, antihypertensives or who have taken any analgesic or anti-inflammatory drugs within 24 hours prior to the surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-94bckz	Effect of laser therapy on clinical aspects and post-operative pain after third molar extraction	Recruiting	Intervention	2020-01-10	<NULL>	<NULL>	3350	Influence of low-level laser therapy on clinical and subjective aspects after third molar extraction: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-18	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-94bckz	<NULL>	"To be included in the sample, patients will need to have the following characteristics:
Display the indication for third molar extraction;
Have a good general state of health that allows dental implant surgery;
Have time and time available to attend dental appointments"	Patients with any of the following characteristics may not be part of the sample: Patient with any systemic disease that prevents oral surgery; Patients who do not have time available for care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4m3mx7	Effects of 940 nm laser application on the control of mouth opening difficulty, swelling, pain and sensitivity after jaw surgery.	Recruiting	Intervention	2020-01-10	<NULL>	<NULL>	3351	Effects of 940 nm laser photobiomodulation therapy on the control of trismus, edema, pain and paraesthesia after orthognathic surgery. Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia da Universidade de São Paulo	Hospital Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4m3mx7	<NULL>	Individuals indicated to undergo bimaxillary orthognathic surgery with genioplasty; removal of third molars at least 6 months before surgery; regardless of gender and race; age group above 18 years; Signature of the Informed Consent Form (ICF).	Individuals submitted to monomaxillary surgery will be excluded; patients under 18 years of age; individuals with temporomandibular joint dysfunction; rupture of the inferior alveolar nerve during the surgical procedure; undesirable fractures; mandibular surgery with execution time above 2:30 h; deficient mandibular fixation; allergy to standardized anti-inflammatory drugs; postoperative infection; individuals who did not cooperate with PBMT therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-467cv6	Analysis of the results of an intensive therapy for the legs in the gait and in the balance of patients who suffered stroke.	Recruiting	Intervention	2019-08-20	<NULL>	<NULL>	3352	Effects of Lower Extremities - Constraint Induced Therapy on gait and balance function in chronic hemipretic post-stroke patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-30	Associação de Assistência a Criança com Deficiência	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-467cv6	<NULL>	Medical diagnoses of stroke, ischemic or hemorrhagic; stroke at least 6 months before study participation; clinically stable; hemiparesis caused by stroke; gait deficit caused by stroke; being able to begin hip and knee flexion on the affected side; moving from sitting to standing independently even with aid or support of upper limbs; being able of transferring while sitting independently; being able to sustain the body weight on the affected side even with support of another person and/or aid; being able of walking at least 10 meters with or without aid, with or without support of another person, barefoot; having only one or two main caregivers or relatives who live with the patient or spend substantial parts of the day with him; being available to go to the rehabilitation center for 17 consecutive days and staying there for 3 hours per day, 15 days of treatment and the first day for initial tests and the last day for the final tests; has not been subjected to orthopedic surgery for at least 6 months at the beginning of the protocol; has not been subjected to chemical block for at least 3 months at the beginning of the protocol; do not present an independent community gait.	Not accepting the protocol for which they were randomly allocated; having speech deficits that incapacitates the participant to understand and/or answer properly to evaluation scales and exercises selected for the protocol and having suffered any clinical event between the screening and the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-7ft6xd	The Influence of Music Associated with Insulin Use on Heart Control of Diabetic People	Data analysis completed	Intervention	2020-01-10	<NULL>	<NULL>	3353	The Influence of Musical Auditory Stimulation Associated with Insulin Use on Cardiac Autonomic Control of Diabetic People	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-13	Faculdade de Juazeiro do Norte	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-7ft6xd	<NULL>	Age between 18 and 60 years; Insulin-dependent diabetics.	Smokers; individuals with cardiorespiratory disorders; neurological; hearing impairment and other known impairments that prevent the subject from performing the procedures; Persons receiving medication that influence cardiac autonomic regulation; Patients with diabetic neuropathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-56jg3n	Effects of Neuromodulation on Blood Pressure of hypertenses submitted to Physical Exercise	Recruiting	Intervention	2019-03-26	<NULL>	<NULL>	3354	Effects of Neuromodulation of insular cortex on Blood Pressure of hypertenses submitted to Aerobic Exercise	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-13	Universidade Federal da Paraíba	Instituto de Educação Superior da Paraíba - IESP	https://ensaiosclinicos.gov.br/rg/RBR-56jg3n	<NULL>	Men and women aged between 18-65 years diagnosed with arterial hypertension (systolic blood pressure greater than 130 and less than 180 mmHg or diastolic greater than 85 and less than 120 mmHg) will be included.	Participants will be excluded if they present a diagnosis of resistant hypertension; history of hematological diseases; neurological diseases; peripheral vascular diseases; stroke; consume more than 30g of alcohol per day; be doing any hormone replacement therapy; have a body mass index greater than 30 kg m²; have cognitive problems that make it impossible to execute commands; present physical limitations that prevent the accomplishment of the exercise protocol; have a dissecting aneurysm and miss more than 3 sessions continuously or lack at least 30% of the stimulation and physical exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5ynbgw	Effect of curcumin-loaded nanoparticles in the treatment of periodontitis.	Recruitment completed	Intervention	2020-01-13	<NULL>	<NULL>	3355	Therapeutic potencial of curcumin-loaded nanoparticles in the treatment of periodontitis: Double-blind split-mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-15	Faculdade de Odontologia de Araraquara - Universidade Estadual Paulista	Conselho Nacional de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-5ynbgw	<NULL>	Healthy; 30 years of age or more; presence of periodontitis, in stage II or III and Grade A, in at least 2 sites in 2 different quadrants, with Probing Pocket depth between 5 and 8 mm and active periodontal disease, verified by the presence of bleeding on probing; minimum 15 teeth present; availability for a period of 6 months	Presence of systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that could interfere with the evolution of periodontal disease and / or treatment outcome; history of gastroesophageal reflux, peptic ulcer, duodenal ulcer and gallstones; gestational or lactating women; smokers or ex-smokers who have stopped smoking for less than 5 years; have been using antimicrobials in the last six months; have been using steroid or non-steroidal anti-inflammatory drugs continuously for more than 7 days in the past 3 months; have received periodontal treatment in the last year; have less than 15 teeth present.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-43r7rf	Efficacy of eletroacupuncture in muscular pain	Recruitment completed	Intervention	2017-04-18	<NULL>	<NULL>	3356	Efficacy of Intramuscular Stimulation Techniques to Treat Chronic Myofascial Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot; Faculdade de Medicina de Botucatu	"Universidade Estadual Paulista ""Julio de Mesquita Filho"" Faculdade de Medicina de Botucatu"	https://ensaiosclinicos.gov.br/rg/RBR-43r7rf	<NULL>	older than 18 years; history of musculoskeletal pain for three months or more; presence of active myofascial trigger points in the upper trapezius muscle in the evaluation; presence of referred pain at the trigger point equal to or greater than three on the Visual Analogue Pain Scale (VAS) for at least five days pre-treatment	cervicobrachialgia for radiculopathy proven by clinical evaluation, neurological signs and / or imaging tests (CT or MRI); patients with diabetes mellitus and other neuropathies; use of opioids and / or other drug therapies less than 1 month; signs and symptoms that meet diagnostic criteria for fibromyalgia; contraindications for the use of electrical stimulation (pacemaker patients, other electro-stimulators); patients taking anticoagulant medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-23ch2p	Effect of topical application of eugenol on dental sensitivity caused by in-office dental bleaching	Recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3357	Effect of topical eugenol application on dental sensitivity caused by in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-23ch2p	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology . Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems, diabetes, hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-9fzfys	TENS in the postoperative anterior cruciate ligament rupture	Recruitment completed	Intervention	2020-01-14	<NULL>	<NULL>	3358	Transcutaneous Electrical Stimulation (TENS) in the immediate postoperative period of anterior cruciate ligament (ACL) reconstruction: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9fzfys	<NULL>	Subjects aged between 18 and 40 years with ACL rupture who underwent surgery through the bone-tendon-arthroscopic technique admitted to the Santa Luzia hospital; Have signed the Informed Consent Form.	Prior rupture of meniscus requiring prior repair; Evidence of degenerative disease on radiological imaging or MRI; Patients with deficit of superficial sensitivity; Patients with loss of level of consciousness; Cognitive disability that makes it impossible to understand and sign the consent form to participate in the study; Patients with previous stroke sequelae; Patients who develop wound infection; Death during the research period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8xcxdf	Effect of exercise on aldosterone, cardiovascular variables in patients with renal disease	Not yet recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3359	Effect of home-based exercise on aldosterone, ventricular mass, arterial stiffness in hemodialysis.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8xcxdf	<NULL>	Age greater than or equal to 18 years; both sexes; with CKD in hemodialytic treatment for a period of more than or equal to 3 months; plasma Aldo above 15 ng / dL; do not present contraindications for performing physical activity.	Patients with cognitive deficits, diagnosis of psychiatric disorders; amputees; pregnant women and non-literates; with a previous diagnosis of coronary artery disease; patients considered to be active or very active according to the IPAQ questionnaire, chronic uncontrolled arterial hypertension with BP of 160/100 mm Hg, positive exercise test for cardiac ischemia; patients who suffered a stroke and / or acute myocardial infarction, neoplasia patients; hepatic insufficiency and patients receiving; spironolactone, occurrence of active infection; change in class and / or drug dose; use of antihypertensives; including use of spironolactone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-7jw4ry	Effects of probiotics supplementation on risk factors for cardiovascular disease in obese hypertensive individuals	Recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3360	Effects of probiotics supplementation on body adiposity, insulin resistance, lipid profile and blood pressure in obese hypertensive individuals during energy restriction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-7jw4ry	<NULL>	Individuals aged 40 to 65 years. Both sexes,  women  in post-menopausal period. Body mass index equal or more than 30.0 and less than 40.0 kg per m². Diagnosis of hypertension on regular treatment with antihypertensive drugs for at least 4 weeks. Signature of the informed consent.	Individuals with evidence of secondary hypertension or presenting blood pressure equal or greater than 160 x 100 mmHg. Diabetes mellitus and or use of insulin or oral hypoglycemic agents. Diagnosis of malignant or autoimmune diseases. Chronic kidney or hepatic diseases. Clinical signs of heart failure or of changes in thyroid function. Use of probiotics, prebiotics, symbiotics, antibiotics, hypolipidemic drugs, hormone replacement therapy, proton pump inhibitors, antioxidant and/or anti-inflammatory supplements including vitamin, mineral or omega 3 in the last 3 months. Recent changes (last 3 months) in body weight (equal or greater than 3kg) and/or in food intake. Current or former smokers (last 12 months). Physical activity practitioners. Vegetarians. Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-9t7zvt	The effects of music education program of guri santa marcelina in São Paulo	Not yet recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3361	The effects on cerebral structure, social, and cognitive abilities on children exposed to guri santa marcelina program  at greater sao paulo: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade estadual paulista júlio de mesquita filho	Associação de Cultura, Educação e Assistência Social Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-9t7zvt	<NULL>	50 six and seven year old children from the experimental group exposed to the Guri Santa Marcelina Program; 100 six and seven year old children from the control group who attend schools at the same communities as the experimental group of children	Children with the percentile 5 of the Raven Color Progressive Matrices test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5bw2wt	The role of the pharmacist in the team care of hospitalized patients with Chronic Brochitis or Emphysema	Not yet recruiting	Intervention	2012-05-01	<NULL>	<NULL>	3362	Pharmaceutical care Programme for inpatients with Chronic Obstructive Pulmonary Disease in a Tertiary Teaching Hospital in Southern Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-01	Hospital de Clínicas de Porto Alegre - UFRGS	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5bw2wt	<NULL>	Inpatients with exacerbation of COPD  at HCPA.	difficulty of understanding (absence of response to verbal commands, severe psychiatric illness, retardation, blindness), psychiatric illness with corresponding CID; metastatic desease; decompensated severe heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8xtkjp	Effects of electrical stimulation for reduction of pain, walking ability and respiratory function in kidney donors	Recruiting	Intervention	2012-10-22	<NULL>	<NULL>	3363	Effects of transcutaneous electrical nerve stimulation on pain, mobility and pulmonary function in kidney donors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-22	Richard Liebano	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xtkjp	<NULL>	Kidney donors submitted to the nefrectomy; aged between 18 and 70 years old and of either sex; Pain intensity at rest greater than or equal to 2 and less than or equal to 7 on a numeric verbal pain scale (0-10)	Previous TENS experience; Need for surgical intervention on another organ in addition to the kidney	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8pxcmm	Use of positive pressure in morbidly obese patients undergoing reduction stomach surgery	Recruitment completed	Intervention	2013-08-05	<NULL>	<NULL>	3364	Use of positive pressure in morbidly obese patients undergoing gastroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Metodista de Piracicaba - UNIMEP	Universidade Metodista de Piracicaba - UNIMEP	https://ensaiosclinicos.gov.br/rg/RBR-8pxcmm	<NULL>	"BMI &gt; 40 kg/m2 and &lt; 55 kg/m2
Surgical procedure like gastric bypass Roux-Y, by laparotomy
Age between 25 and 56 years
Pulmonary function tests normal
Nonsmoker
Absence of respiratory diseases"	"Hemodynamic instability
Abnormalities in pulmonary function test
Permanence greater than three days in the hospital
Presence of postoperative complications"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-2gkwct	Evaluation of the synergic effect of non-elastic mechanism compression adjusted and unadjusted in exercise type walk in the treatment of lymphedema	Recruitment completed	Intervention	2013-07-04	<NULL>	<NULL>	3365	Synergic effect in the setting of non-elastic mechanisms compression in the treatment of lymphedema	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Vascular Laser Center-Clinica Godoy	Vascular Laser Center-Clinica Godoy	https://ensaiosclinicos.gov.br/rg/RBR-2gkwct	<NULL>	Presence of congenital lymphedema or other cause of lower limb or with clinical diagnosis and lymphoscintigraphy.	Exclusion criteria were lymphedema with osteoarticular problems and active infection during the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-7kcqtm	Evaluation of movements, mastication and satisfaction of denture wearers after use of two adhesives	Recruitment completed	Intervention	2014-02-17	<NULL>	<NULL>	3366	Eletrocinesiographic evaluation, of masticatory performance and satisfaction of complete denture wearers after use of two adhesives	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7kcqtm	<NULL>	"Adults; mentally agile and responsive;
resilience and alveolar volume normal;
absence of disfunctions of the stomatognathic system; absence of debilitating systemic changes; no need to use adhesive after fabrication of new dentures"	Debilitating neurological or systemic diseases; cardiac pacemaker; need for pre-prosthetic surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-47kfxh	Effect of Floral Therapy on Anxious Overweight Adults	Recruitment completed	Intervention	2018-01-16	<NULL>	<NULL>	3367	Efficacy of Floral Therapy in the Anxiety of Overweight or Obese adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-47kfxh	<NULL>	Healthy individuals; both sexes; literate; aged between 20 and 59 years; overweight or obese (Body mass index greater than 25 kg / m2); and with moderate or high anxiety according to the criteria of the State Anxiety Inventory (Score greater than 34).	Individuals who are taking medications to lose weight or control anxiety or depression; In psychological treatment and / or using other complementary therapies; in addition to women suspected of being pregnant or pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-98wb56	Adaptation of the Denture after the installation	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	3368	Influence of the Height of the Mandibular Ridge on the functional adaptation with Dentures	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-98wb56	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years, of both genders; users conventional complete dentures; requiring replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders; use of a cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-98hj9x	Applications of Physioterapy Equipments in Low Back Pain	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	3369	Application of Electrothermalphototerapeutic Current in patients with Lumbar Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-98hj9x	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back; gives; not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-7fjg33	Study of the effects of drug therapy associated with aerobic physical exercise on blood pressure and heart beats in women with high blood pressure before and after menopause	Recruiting	Intervention	2019-09-18	<NULL>	<NULL>	3370	Study of the association of aerobic physical training with Enalapril Maleate and Losartan on different cardiovascular parameters in hypertensive women, before and after menopause	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-04	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7fjg33	<NULL>	Women between 30 and 65 years of age; sedentary; with a diagnosis of systemic arterial hypertension stage I; under pharmacological treatment with Losartan or Enalapril Maleate	We will exclude women with cognitive disorders that impede the understanding of the tests and the aerobic physical training; with musculoskeletal disorders; endocrine diseases; metabolic diseases; cardiovascular diseases, except systemic arterial hypertension; smokers; women who use drugs that interfere with cardiac function and cardiovascular autonomic control; besides those that use hormone replacement after menopause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8twhkb	Effects of Babassu Coconut Oil intake on fatigue and quality of life of breast cancer women	Recruitment completed	Intervention	2017-10-24	<NULL>	<NULL>	3371	Effects of supplementation of Babassu Coconut Oil in the fatigue and quality of life of women with breast cancer	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8twhkb	<NULL>	Individuals of the female gender; age greater than or equal to 30 and up to 59 years; in all anti-neoplastic treatment; not be using dietary supplementation for at least 3 months; stage IIA to IV of the disease.	Pregnant women, patients unable to communicate verbally and even to get around, mental disorders, use of mineral oil or lactulone, carriers of some biliary disease, use of hypocholesterolemic medication, not want to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5whk7c	toxicity, and the drug dosing parameters evaluations comparing dispersible tablets of efavirenz and oral liquid in children;	Recruitment completed	Intervention	2016-04-05	<NULL>	<NULL>	3372	open, randomized study for safety evaluation and pharmacokinetic parameters comparing dispersible tablets and efavirenz oral solution in pediatric population;	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade Federal de Minas Gerais	Instituto de Tecnologia em Fármacos - Farmanguinhos	https://ensaiosclinicos.gov.br/rg/RBR-5whk7c	<NULL>	"Age greater than or equal to 3 years and less than 13 years old; weight between 7.5 and 35kg, HIV infection confirmed, documented by positive results from two samples collected at different times prior to entering the study, according to the criteria Sample # 1 below can be tested using rapid tests Two different two or based on different principles and antigenic determinants manufacturers antibodies (only for largest survey participants 18 months);
An EIA or western blot assay, or immunofluorescence assay OR chemiluminescence assay (only for largest survey participants 18 months); A PCR HIV DNA; A quantitative PCR HIV DNA (&gt; 5,000 copies / mL); Qualitative PCR DNA of HIV; a complete test of nucleic acid detection for the HIV virus; Sample # 2 can be tested using: a confirmed EIA test or Western blot OR immunofluorescence test or chemiluminescence test (only for largest survey respondents 18 months); a PCR HIV DNA; a quantitative PCR HIV DNA (&gt; 5,000 copies / mL); qualitative PCR HIV DNA, complete testing detection of nucleic acids for the HIV virus; patient using of antiretroviral regimen containing EFV and criteria showing virologic suppression, or
Patient with antiretroviral treatment early indication that have a genotyping test indicating absence of mutations to confirm resistance to EFV; Demonstrate availability and willingness to ingest the drugs under study; availability to stay in the hospital for 24 hours for pharmacokinetic study, parents or legal guardians must be able, agree and are willing to sign the consent form Clarified; female participants, after menarche and sexual activity that can result in pregnancy will be guided by the principal investigator, or someone delegated team for him, to avoid pregnancy using at least two contraceptive methods, preferably a hormonal method and another barrier method. The study sponsor will bear the costs of contraceptive methods."	"laboratory test values outside the normal range greater than grade 3 according DAIDS Table toxicity (Annex IV), up to 2 weeks prior to study entry or at any time during the study; Vomiting and diarréiadiarreia (
greater than grade 2) 30 days prior to study entry; treatment for bacterial, viral or opportunistic severe acute; History toxicity to drugs requiring discontinuation of any study drug; Hypersensitivity to study medications, medical or surgical problems that affect the motility or absorption gastrointestinal (eg, ileus, ulcerative colitis) or liver function, treatment with experimental drugs within 30 days prior to study entry; any acute hepatitis, chemotherapy for cancer; Any disease or findings clinically significant for the medical assessment or physical examination that, in the opinion of the investigator, may interfere with the study, immune failure defined as:
• incomplete immune response: defined as a failure, in patients with severe immunodeficiency (baseline CD4 percentage 
greater than 15%), to achieve at least five percentage points of growth, or for children 5 years old, to increase the CD4 absolute value of at least 50 cells / mm3 during the first year of treatment.
• immune Worsening: defined as the sustained drop of five points on CD4 percentage at any age, or fall to values below the absolute number of CD4 pretreatment in children 5 years old (Brazil, 2009); Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-6tvbdn	Evaluation of the efficacy of listening to music before blood donation on anxiety: a randomized clinical trial	Recruitment completed	Intervention	2017-06-19	<NULL>	<NULL>	3373	The effect of music on blood donor anxiety: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Triângulo Mineiro	Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (Hemominas)	https://ensaiosclinicos.gov.br/rg/RBR-6tvbdn	<NULL>	Blood donors;	Blood donors who have a deficit or hearing problems; who are classified as sporadic donors (donor repeating donation after more than 12 months of the last donation); who are using anxiolytic medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4pgn3c	Applications of one Physioterapy Equipment in Low Back Pain	Not yet recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3374	Aussie current application in low back pain patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4pgn3c	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than 3 ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back;  not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-6djxqz	Effects of a physical exercise program on cardiac function of patients with Heart Failure	Recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3375	Effects of a combined physical exercise program on cardiac function and biochemical and cardiovascular genetic markers of patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital das Clínicas da Faculdade de Medicina de Botucatu	"Faculdade de Medicina de Botucatu (FMB) - Universidade Estadual Paulista ""Júlio de Mesquita Filho"" (UNESP)"	https://ensaiosclinicos.gov.br/rg/RBR-6djxqz	<NULL>	Will be included participants older than 18 years; both sexes; heart failure with reduced ejection fraction (HFrEF) of various etiologies and optimized drug therapy.	Patients with heart failure grade III and IV and stage D; Hypertrophic cardiomyopathy; Deposit diseases; Mitral and aortic stenosis; Decompensated heart failure in the last three months; Persistent or permanent atrial fibrillation and/or artificial pacemaker rhythm; Chronic obstructive pulmonary disease; Biomechanical limitations that prevent them from participating in the proposed combined physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-8f645t	The effects of electrical brain stimulation on Social Anxiety	Recruiting	Intervention	2020-01-16	<NULL>	<NULL>	3376	Effects of Transcranial Direct Current Stimulation in Social Anxiety symptoms: a clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-8f645t	<NULL>	Volunteers diagnosed with social anxiety disorder; Both sexes; Aged 18 to 40 years	History of seizure or any other neurological diagnosis; Present psychiatric comorbidities; Have a metal implant in any region of the head; Use pacemaker; Be pregnant; Have passed ETCC protocol less than 4 months ago; Make use of dextromethorphan, propranolol and / or amphetamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9b4qgq	Prepared platelets and tranexamic acid knee prosthesis surgery	Recruitment completed	Intervention	2016-10-06	<NULL>	<NULL>	3377	Platelet Rich Plasma (PRP) and Tranexamic Acid (TXA) Applied in Total Knee Arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Irmandade Santa Casa de Londrina	Irmandade Santa Casa de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-9b4qgq	<NULL>	Volunteers with knee osteoarthritis Severa and indication of total knee prosthesis for treatment	inflammatory diseases; hematological diseases; great deformities; use of anticoagulants previously	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-65dynt	Effect of coffee mouth rinse on cycling performance	Recruiting	Intervention	2020-01-16	<NULL>	<NULL>	3378	Effect of Coffee Mouth Rinse on cycling performance: an randomized cross-over clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-24	Lara Lima Nabuco	Faculdade de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-65dynt	<NULL>	Healthy; normal-weight men; mountain-bike riders; stable body weight over the past three months; regular caffeine users;age between 20 and 40 years old; non-smokers; keep alcohol consumption below seven units / week; experienced cyclists or triathletes (at least 1 year of training) with regular training, maintaining a total of at least 150 km of cycling training per week, with at least 50 km on track.	Individuals who have consumed more than 500 mg of caffeine per day in the last month (~ 5 cups of coffee or tea, cola drinks or caffeine pills); medical condition; food intolerances or allergies;food supplement (except protein, carbohydrate and caffeine); drug treatment that interferes with the test results;those who do not agree with the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-7x28v3	Effects of isolated versus combined perineal preparation methods on perineal stretching and muscle strength	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	3379	Effects of isolated versus combined perineal preparation methods on perineal distensibility and muscle strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-29	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7x28v3	<NULL>	Pregnant women at the 33rd gestational week, in the age group 18-40 years, both primiparous and women who experienced miscarriages before the 21st week of previous pregnancies, who presented muscle strength &gt; 1 (based on the modified Oxford Scale) and who were subjected to vaginal palpation.	Participants who missed two consecutive interventions, who had urinary tract infections during the study and whose pregnancy came to an end before the last evaluation were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8s9y2q	Effect of chest tube insertion site on pulmonary function in patients undergoing cardiac surgery	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3380	Effect of chest tube insertion site on ventilatory function in patients undergoing elective myocardial revascularization surgery: a clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2014-07-31	sandra simon	Fundação Universitária de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8s9y2q	<NULL>	Patients aged 40 to 80 years; indication for myocardial revascularization surgery with left internal thoracic artery graft and associated pleurotomy	Severe neuropsychiatric deficit; requiring other parallel surgical interventions; with no indication for pleurotomy; symptomatic abdominal hernias; previous diagnosis of stroke or any other conditions that prevented the performance of the manovacuometer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-3crsfj	Clinical trial to compare the efficacy and safety between the combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) and COMBIGAN® (combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing ocular pressure in adult patients with primary open-angle glaucoma or high pressure in the eyes	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3381	Phase III, multicenter, double-blind, randomized, controlled, 12-week, parallel-group, superiority trial to compare the efficacy and safety of the triple fixed combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) versus COMBIGAN® (double fixed combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing intraocular pressure (IOP) in adult patients with primary open-angle glaucoma or ocular hypertension	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-06-01	Laboratório Daudt Oliveira Ltda.	Centro de Pesquisa Clínica São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-3crsfj	<NULL>	Men or women aged 18 years-old or over; having a diagnosis of primary open-angle glaucoma or ocular hypertension; being able to sign the ICF approved by IRB and to execute and understand all study procedures and instructions; having intraocular pressure greater than or equal to 21 and less than or equal to 30 mmHg in, at least, one eye; having an optical disc excavation of 0,8 or less	"Presenting blindness in one eye; having visual acuity worse than or equal to 20/40 in either eye without justified cause; presenting a history of any concomitant active-stage eye disease, except those specified in
inclusion criteria; for participants taking medication to treat primary open-angle glaucoma or ocular hypertension may only participate in the study if they discontinue the drug for a period of up to 7 (± 2) to 30 (± 2) days, according to the therapeutic class of the medication used; making use of topical corticosteroids ophtalmic or topical within
14 days from the screening visit. It is prohibited the use of systemic corticosteroids and psychotropic medicines with adrenergic potential (eg desipramine, amitriptyline) within 1 month of the screening visit or any other medication which, regardless of the route of administration, interfere with the study results and offer a risk to the participant&apos;s safety, at the investigator&apos;s discretion, used within 48 hours prior to the screening visit or until residual effects may be present; having an allergy to sulfa drugs; having hypersensitivity to the active ingredients and excipients of the study medications; wearing contact lenses 7 days before the screening visit (pre-treatment) and throughout the study; current history of bronchial asthma or chronic obstructive pulmonary disease (COPD), sinus bradycardia, 2nd or 3rd degree heart block, heart failure, cardiogenic shock; current or previous history of severe renal or hepatic impairment,
current history of diabetic retinopathy or any other clinical condition that, at the investigator&apos;s discretion, contraindicates participation in the study or interferes with the study outcome; participants of childbearing age who do not agree to use a
adequate form of contraception; pregnant, nursing women who plan to become pregnant, or who have a positive pregnancy test on their blood test; having a history of cataract surgery with or without intraocular lens (IOL) implantation (pseudoaphakia or aphakia) within 3 months or less prior to the screening visit; having a recent history of alcohol and/or drug abuse or excessive alcohol consumption; presenting corneal abnormalities that interfere with an accurate reading of intraocular pressure by a Goldmann applanation tonometer; being part of a clinical study within the last 12 months unless, at the discretion of the investigator, it represents a benefit to the participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-76gg53	Radio Electric Asymmetric Conveyer neurobiological modulation approach in post-traumatic knee medial collateral ligament lesion.	Recruitment completed	Intervention	2020-01-20	<NULL>	<NULL>	3382	Modulação neurobiológica Reac em lesões pós traumáticas	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-01-05	Universidade Federal do Amapá	Istituto e Fondazione Rinaldi Fontani	https://ensaiosclinicos.gov.br/rg/RBR-76gg53	<NULL>	Subjects of both sexes. Who report a post-traumatic second or third degree lesion of the medial collateral ligament of the knee.	Previous other joint disorders of the traumatized knee	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-2vkjzp	Analysis of jaws position in orthognathic surgery using zygomatic supported guides	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3383	Accuracy analysis of jaws position in orthognathic surgery using intermediate guides supported on zygomatic bones	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-02-10	Obras Sociais Irmã Dulce	Obras Sociais Irmã Dulce	https://ensaiosclinicos.gov.br/rg/RBR-2vkjzp	<NULL>	Individuals over than 18 years; without comorbidities; with facial deformities; with indication for maxillomandibular surgery for correction	Individuals requiring isolated surgery of the maxilla or mandible;individuals with diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-6vs56t	The influence of the type of drilling in the success of dental implants: Randomized clinical trial	Recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3384	Assessment of implant success, survival, postoperative pain and marginal bone alterations  using a single bur versus multiple drilling: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6vs56t	<NULL>	"This project will be submitted for approval by the Research Ethics Committee of the UFPel School of Dentistry, prior to its completion.
To be included in the sample, patients will need to have the following characteristics:
Present edentulism with an indication of dental implant installation and subsequent dental prosthesis or indication of extraction of a dental element by crack/fracture or root perforation with an indication for immediate dental implant installation and subsequent dental prosthesis; Have a good general state of health that allows dental implant surgery; Have time and time available to attend dental appointments at institutions."	Patients with any of the following characteristics may not be part of the sample:  Patient with any systemic disease that prevents surgery for dental implant installation; Patients with a history of chemo/radiotherapy in the last 10 years or who use systemic medications that may interfere with bone repair (eg, bisphosphonates); Patients who do not have time available for care in educational institutions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-96g5cq	"Comparative study of Dexamethasone associated with
Nimesulide and Dexamethasone plus Paracetamol in
control of Pain, Swelling and postoperative Oral Opening Difficulty"	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3385	"Comparative study between Dexamethasone co-administered with
Nimesulide and Dexamethasone co-administered with Paracetamol in
postoperative Pain control, Edema and Trismus"	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-06-20	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-96g5cq	<NULL>	"Voluntary patients, coming from spontaneous demand from the Unified Health System (SUS), attended at the dependencies of the UERN Dentistry Course;
Between 16 and 45 years old;
Agree to participate in research after reading the Informed Consent Form (ICF);
Classified according to the American Society of Anesthesiology (ASA), in group I (normal healthy, with no systemic changes or continuous use of medications);
With indication of lower third molar extraction, bilaterally. These, necessarily, with the same degree of inclusion as compared to their contralateral, following the classifications of Pell and Gregory and Winter."	"Report having had unpleasant previous experiences (reactions or allergic processes) to any of the drugs used in this research;
Use concomitant medication (except for oral contraceptives);
Do not fit into the planning of surgical and anesthetic techniques;
Not returning for the second surgery, (surgery on the opposite side);
Do not return to the assessments;
Inability to answer the questionnaires;
Do not correctly fill in the evaluation forms."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-4vgzyt	Increased gum thickness around pig collagen graft implants: randomized split-mouth clinical trial	Recruitment completed	Intervention	2020-01-20	<NULL>	<NULL>	3386	Perimplant Mucosa Thickness Modification with Xenogen Acellular Collagen Matrix (Mucoderm): Randomized Split-Mouth Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-05	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4vgzyt	<NULL>	"Be 18 years of age or older;
Have loss of at least two teeth indicated for dental implant placement;
Have good control of visible plaque (Visible plaque index &lt;20%)."	"The exclusion criteria will be:
Present active periodontal disease;
Need for guided bone regeneration prior to implant placement
Possess systemic disorder or be on drug therapy that interferes with healing, such as uncontrolled diabetes, blood dyscrasias (hemophilia, thrombocytopenic purpura), the use of steroids or high doses of anti-inflammatory drugs;
Present allergy to collagen;
Smoking;
Gestation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8k2928	Palbociclib plus letrozole treatment for women  ovarian cancer	Not yet recruiting	Intervention	2020-01-21	<NULL>	<NULL>	3387	Palbociclib plus letrozole treatment for women with ER/PR-positive ovarian cancer after progression to second line chemotherapy	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-12-02	Latin American Cooperative Oncology Group	Latin American Cooperative Oncology Group	https://ensaiosclinicos.gov.br/rg/RBR-8k2928	<NULL>	"Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study;subject is willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures; eighteen years of age or older; patient agrees not to participate in another interventional study while on treatment; histologically diagnosed endometrioid or high-grade serous ovarian cancer, estrogen and or progesterone receptor positive, defined as more than ten percent by immunohistochemistry;
NOTE: The ER and PR status must be centrally reviewed before treatment allocation. Patients must have completed two previous courses of chemotherapy: The penultimate regimen must be a platinum based chemotherapy course prior to enrolment on the study: For the last chemotherapy course prior to enrolment on the study: There is no prespecified regimen; it may contain a Platinum salt or not, depending upon Platinum sensitivity, at discretion of treating Physician; patients must have demonstrated disease progression by RECIST v1.1 to the last treatment. Patients must be treated on the study within eight weeks of completion of their final dose of second line regimen; formalin fixed, paraffin embedded tumor sample from the primary tumor must be available for central testing; eastern One. Cooperative Oncology Group performance status  Two; adequate bone marrow function at screening: Absolute Neutrophil Count 1,500 to mm³. Platelets 100,000 to mm³. Hemoglobin 9.0 g to dL; adequate liver function at screening: Total serum bilirubin 1.5 x upper limit of normal, 3.0 x ULN if Gilbert Syndrome. Aspartate aminotransferase and alanine aminotransferase 3.0 x ULN, 5.0 x ULN if there is tumor involvement in the liver. Alkaline phosphatase 2.5 x ULN, 5.0 x ULN if there is tumor involvement in the liver; adequate renal function at screening: Serum creatinine 1.5 x ULN or estimated creatinine clearance 50mL to min; evidence of nonchildbearing potential: Postmenopausal, defined as at least one year without any menses, prior to screening, or radiation induced oophorectomy with last menses more than one year ago, or surgical sterilisation, bilateral oophorectomy or hysterectomy."	Patients with a known hypersensitivity to Palbociclib or Letrozole or any of the excipients of the product; previous treatment with CDK inhibitors or endocrine therapy; persistent toxicities, grade two or greater, caused by previous cancer therapy, excluding alopecia; patients with second primary cancer, except: adequately treated non melanoma skin cancer, curatively treated in-situ cancer of the cervix, Ductal Carcinoma in Situ, stage one grade one endometrial carcinoma curatively treated with no evidence of disease for three years; patients receiving any chemotherapy, radiotherapy, within three weeks from the last dose prior to study entry; patients with symptomatic uncontrolled brain metastases. A scan to confirm the absence of brain metastases is not required; major surgical procedure within three weeks prior to study randomization, or one is planned during the course of the study; patients considered poor medical risk due to a serious, uncontrolled medical disorder, non malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent, within six months, myocardial infarction, cerebrovascular accident, gastrointestinal bleeding, or any psychiatric disorder that prohibits obtaining informed consent; patients that have difficulty taking oral medication or any digestive tract dysfunction or inflammatory bowel disease that would interfere with the intestinal absorption of drugs, eg, partial bowel obstruction or malabsorption; patients have received potent inhibitors or inducers of CYPthreeAfour within seven days prior to randomization; pregnant or breast feeding women; patient has a known history of positive test for human immunodeficiency virus; patients with known hepatic disease, ie, Hepatitis B or C; subjects who are investigational site staff members directly involved in the conduct of the trial and their family members, site staff members otherwise supervised by the Investigator, or subject who are Pfizer employees directly involved in the conduct of the trial; treatment with any investigational product during the last twenty-eight days; QTc greater than 480ms, QT syndrome, Brugada syndrome, history QTc prolongation or Torsade de Points; other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-39ght5	Study of effect and duration of botox in the treatment of gnash or clench your teeth	Recruitment completed	Intervention	2020-01-21	<NULL>	<NULL>	3388	Efficacy and Durability of Botulinum Toxin in the Treatment of Bruxism - Double Randomized Blind Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-25	Universidade Ibirapuera	Universidade Ibirapuera	https://ensaiosclinicos.gov.br/rg/RBR-39ght5	<NULL>	Participants of both genders aged 18 to 70 years; participants complaining of clenching, compressing or grinding their teeth for at least 6 months; Masseter and temporal muscle hypertrophy; participants presenting: Headache / chronic orofacial pain, chewing pain, pain on palpation of the chewing and / or facial muscles (middle and lower third of the face).	Participants with BTX-A or albumin allergy; participants have already had botulinum toxin treatment on these muscles for less than 12 months; pregnant or planning to become pregnant or lactating women; participants who are participating in other research involving other drugs; participants taking drugs that interfere with neuromuscular transmission (Aminoglycosides, Anticholinesterases, etc.) or who are taking antibiotics and corticosteroids; participants who are undergoing orthodontic treatment or using a bite plate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8p6zyy	Pilates in volleyball	Recruitment completed	Intervention	2020-01-22	<NULL>	<NULL>	3389	"Evaluation and analysis of motor performance and biopsychosocial conditions in
young volleyball players"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8p6zyy	<NULL>	"Will be included in the study athletes who:
Practice male volleyball, under 15 and under 17.
Attend the Uberaba City Sports Training School.
Whose guardians agree to sign the free and informed consent form;
Have a training frequency of twice a week and maintain weekly training hours of at least nine hours."	"Athletes will be excluded from the study if:
Be suspended from training program;
Have muscle injury in the intervention period and / or evaluation for some game;
They underwent orthopedic surgery in the knee, ankle, hip during the evaluation period and / or intervention;
Do not attend the evaluations and / or interventions for two consecutive days;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9t6rd7	Effects of sildenafil on the pulmonary microvascular disease of symptomatic smoker	Not yet recruiting	Intervention	2020-01-22	<NULL>	<NULL>	3390	Effects of sildenafil on exercise responses in symptomatic individuals with evidence of tobacco-associated pulmonary microvascular disease: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal de Mato Grosso do Sul	Hospital Universitário de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9t6rd7	<NULL>	Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.	"Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation;
Contraindication to the use of sildenafil citrate or previous use of it thereof."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9jgq9c	Evaluation of gynecological, proctological and dermatological acceptability of product for health under normal conditions of use	Not yet recruiting	Observational	2020-01-22	<NULL>	<NULL>	3391	Evaluation of gynecological, proctological and dermatological acceptability of product for health under normal conditions of use_mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-27	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-9jgq9c	<NULL>	Women; Age 18 to 65 years; Phototype I to IV; Whole skin of the region; Occasional user of category products	"Skin markings in the experimental area that interfere with the evaluation of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; History of atopy; Use of vaginal cream; Participants with a history of allergy to products of the tested category; Recent gynecological surgeries; Discharge; Carriers of immunodeficiencies; Kidney, cardiac or liver transplantation; Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before study start; Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not using products in the same category as the product tested in the experimental region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-4kcvpb	Rehabilitation with complete fixed prosthesis on implants by digital and conventional flow	Recruiting	Intervention	2020-01-22	<NULL>	<NULL>	3392	Implant-supported fixed prosthesis rehabilitation made by digital and conventional workflow	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Norte	Universidade Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4kcvpb	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use and presenting the need for rehabilitation with a fixed implant supported prosthesis retained by four implants	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8z787r	A Study without Drug Intervention to Observe Bleeding Episodes, Factor VIII Infusions, and Patient-Reported Outcomes in Individuals with Severe Hemophilia A	Recruitment completed	Observational	2018-11-06	<NULL>	<NULL>	3393	A Prospective Non-Interventional Study of Bleeding Episodes, Factor VIII Infusions, and Patient-Reported Outcomes in Individuals with Severe Hemophilia A	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	BioMarin Pharmaceutical Inc.	UNICAMP - Campus Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8z787r	<NULL>	"Males major of 18 years of age with hemophilia A and residual FVIII levels minor or equal 1 IU/dL, as evidenced by medical history, at the time of signing the informed consent.
Must have been on prophylactic FVIII replacement therapy for at least 6 months prior to study entry. High-quality, well-documented historical data concerning bleeding episodes and FVIII usage over the previous 6 months must be available.
Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure days (EDs).
Willing and able to provide written, signed informed consent after the nature of the study has been explained and prior to any study-related procedures.
No history of FVIII inhibitor, and results from a Bethesda assay with Nijmegen modification of less than 0.6 Bethesda Units (BU) on 2 consecutive occasions (the most recent one of which should be tested at the central laboratory) at least one week apart previously.
Known status of antibodies against the AAV5 capsid. Participants may be either AAV5- or AAV5+.
HIV-positive patients may be enrolled, only if the patient has a CD4 count &gt; 200/mm3 and an undetectable viral load.
Have the ability to comply with protocol requirements in the opinion of the Investigator."	"Significant liver dysfunction with any of the following abnormal laboratory results:
ALT (alanine transaminase) or AST &gt;2X upper limit of normal (ULN);
Total bilirubin &gt;2X ULN;
Alkaline phosphatase &gt;2X ULN; or
INR (international normalized ratio) major or equal 1,4
Patients whose liver laboratory assessments fall outside of these ranges may undergo repeat testing and, if eligibility criteria are met on retest, may be enrolled after confirmation by the Medical Monitor. In addition, patients with abnormal laboratory results related to confirmed benign liver conditions (eg, Gilbert’s syndrome) are considered eligible for the study notwithstanding their abnormal laboratory results and may be enrolled after discussion with the Medical Monitor.
Prior liver biopsy showing significant fibrosis of 3 or 4 as rated on a scale of 0-4 on the Batts-Ludwig (Batts 1995) or METAVIR (Bedossa 1996) scoring systems, or an equivalent
grade of fibrosis if an alternative scale is used.
Liver cirrhosis of any etiology as assessed by prior liver ultrasound.
Chronic or active hepatitis B as evidenced by positive serology testing and confirmatory HBV DNA testing. Refer to the Centers for Disease Control (CDC) table for the interpretation of serological test results in the Laboratory Manual.
Active hepatitis C, as evidenced by detectable HCV RNA or currently on antiviral therapy.
Active malignancy, except non-melanoma skin cancer.
History of hepatic malignancy.
Evidence of any bleeding disorder not related to hemophilia A.
Has a medical condition or extenuating circumstance that, in the opinion of the Investigator, might compromise the participant’s ability to comply with protocol requirements, the
participant’s wellbeing or safety, or the interpretability of the participant’s clinical data.
Prior treatment with any vector or gene transfer agent.
Concurrent enrollment in another clinical study, unless it is an observational (noninterventional) clinical study that does not interfere with the requirements of the current protocol and with prior consultation with the Medical Monitor.
Unwilling to receive blood or blood products for treatment of an AE and/or a bleeding episode."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-96qpwn	Effect of the time use of a Bleaching Gel on the efficacy of and Dental Sensitivity to At-home Bleaching	Recruitment completed	Intervention	2018-12-01	<NULL>	<NULL>	3394	Effect of application time of 4% Hydrogen Peroxide on the efficacy of and dental sensitivity to At-home Bleaching: a blind parallel randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-22	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-96qpwn	<NULL>	Volunteers over 18 years old in good general and oral health; who have healthy vital teeth with color A2 or darker according to the Classical Vita scale; and to agree with the free and informed consent form.	Volunteers who have already undergone dental bleaching; who have dental prosthesis or visible enamel cracks; who are pregnant or breastfeeding; a history of previous dental sensitivity; severe dental discoloration from pathologies or use of medications; fixed orthodontic appliance; and that are making continuous use medication that may reduce the sensitivity of the teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-83vb6b	The effect of resistance exercise with instability in the patients with Parkinson&apos;s disease	Data analysis completed	Intervention	2018-06-28	<NULL>	<NULL>	3395	Effects of resistance training with instability on clinical outcomes, Spinal Mechanisms, and Brain Metrics in individuals with freezing of gait in Parkinson’s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-25	Escola de Educação Física e Esporte da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83vb6b	<NULL>	All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional; All patients must present the clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist; to present freezing of the gait; to present between 49 and 85 years of age; to present Parkinson&apos;s disease between stages 3 and 4 and  do not perform regular exercise weights six months before starting the training intervention.	Patients who present symptoms of dementia; depression; joint problems; cardiovascular diseases (except hypertension) and claustrophobia will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-32ds8h	Effects of treadmill lateral walking in individuals with Parkinson disease	Recruiting	Intervention	2020-01-24	<NULL>	<NULL>	3396	Immediate effects of lateral walking treadmill training in individuals with Parkinson disease: randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-22	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-32ds8h	<NULL>	Be between stages 2 and 3 of the Hoehn and Yahr Scale; make regular use of antiparkinsonian medication; without any type of orthotic or gait aid, independently (scores 3 to 5 of the Functional Ambulatory Category - FAC), by at least 10 meters; do not have severe cognitive deficits that impede the comprehension of simple verbal instructions (detectable through the Montreal Cognitive Assessment (MoCA) scale); and have not undergone stereotaxic surgery.	Present blood pressure (BP) with systemic and diastolic values above 200 mmHg and 110 mmHg, respectively, before or during training; heart rate (HR) above the values shown, calculated by the formula [HRsub = 0.75x (220-age)]; present other types of neurological, musculoskeletal, cardiovascular, respiratory, visual and / or hearing disorders that make treadmill gait training impossible and an application of the protocol; any change in dosage and / or type of antiparkinsonian drug; and presence of pain, dyspnea and / or severe muscle fatigue that prevents the inheritance of the training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-56f3p8	Evaluation of range of motion gain in posterior thigh muscles after cryotherapy associated with stretching in sedentary women	Recruitment completed	Intervention	2019-11-21	<NULL>	<NULL>	3397	To identify the gain in extensibility of ischiotibial muscles after Cryostretching in sedentary women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-56f3p8	<NULL>	Individuals with retraction of the ischiotibial muscles; female; age between 18 and 30 years; sedentary; not performing physical activities in the ischiotibial muscles	Unconsolidated lower limb fracture; joint hypermobility; any musculoskeletal degenerative disease; cognitive deficit; recent trauma and/or surgical intervention in lower limbs; acute inflammatory process in lower limbs; arteriosclerosis; peripheral vascular disease; vasoespasm (Raynaud&apos;s disease); cold urticaria; altered skin sensitivity; obese	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8g6jbf	Sentinel lymph node biopsy versus no axillary surgery in early breast cancer	Recruiting	Intervention	2020-01-25	<NULL>	<NULL>	3398	Sentinel lymph node biopsy versus no axillary surgery in early breast cancer clinically  and ultrasonographically node-negative	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-02	Hospital da Mulher Prof. Dr. Jose Aristodemo Pinotti - CAISM - UNICAMP	Hospital da Mulher Prof. Dr. Jose Aristodemo Pinotti - CAISM - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-8g6jbf	<NULL>	Women with invasive breast carcinoma; tumor smaller than 5 cm (T1 or T2); negative axilla in clinical exam and ultrasound (with or without core biopsy or fine needle biopsy); older than 18 years; no previous diagnostic of invasive neoplasia (excluded skin cancer no melanoma); written informed consent	Withdrawal from participating of the study; metastatic disease in biopsy or image before treatment; pregnancy; breastfeed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-76zy82	The effect of nursing interventions with families for children care who performed scheduled surgeries	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3399	Effectiveness of family nursing interventions for children care undergoing elective surgeries: a randomized controlled superiority trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de São Paulo, Escola Paulista de Enfermagem	Universidade Federal de São Paulo, Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-76zy82	<NULL>	Neonates, infants, preschoolers and schoolchildren;Presence of at least one family member over 18 years old during family meetings with the nurse who will perform the intervention;Expected hospital stay of 72 hours or more;Patient undergoing elective surgeries including cardiac, gastrointestinal, urological, genitourinary	Illiterate family member (s), without command of the Portuguese language, with any psychic, physical and / or cognitive disorder that makes verbal communication difficult;Death of the child during the study period Children with diseases or comorbidities that lead to neurological, motor, muscle, functional and disabling disabilities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-2h9qkd	Clinical evaluation of tooth restoration using an agent by only one insertion	Recruitment completed	Intervention	2020-01-27	<NULL>	<NULL>	3400	Clinical behavior of single increment composites: randomized controlled longitudinal study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdades Integradas Pitágoras de Montes Claros	Universidade de Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-2h9qkd	<NULL>	over 18 years old; patients who had posterior teeth with active and / or cavitated caries lesions, requiring restoration with direct restorative material, but free of proximal caries according to interproximal radiographic examination; patients who already had class I restorations within score 5 (Clinically poor: International Dental Federation - IDF) on at least one of the following criteria: surface gloss; surface and margin staining; combination of color and translucency; anatomical form; fracture and retention of material; marginal adaptation; patient satisfaction; postoperative sensitivity; recurrence of caries.	patients contraindicated for dental treatment due to their medical history; xerostomia patients or who were taking medication that significantly reduced salivary flow; patients with parafunctional habits of bruxism and teeth clenching and / or attrition; patients who did not have teeth antagonist to the element indicated for the restorative procedure; patients with endodontically treated teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8z86dk	Effects of Ozone  and Physiotherapy on the treatment of Rheumatoid Arthritis of the hands	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3401	Effects of Ozone Therapy and Kinesiotherapy on the treatment of Rheumatoid Arthritis of the hands	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-28	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-8z86dk	<NULL>	"Individuals aged 18 and over; People of both sexes;Patients diagnosed with hand 
rheumatoid arthritis."	Individuals with severe neuromotor sequelae; Patients unable to verbalize or perform the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-6qjtb4	Effect of Tibial Nerve Stimulation in patients with Urinary Incontinence after surgery to Remove the Prostate	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3402	Percutaneous Tibial Nerve Stimulation in patients with Urinary Incontinence after Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-17	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6qjtb4	<NULL>	Men who underwent radical prostatectomy with urinary incontinence after the cateter removal, defined by a volume greater than 1.0 gram on the pad test and who agreed to participate in the research	Men who are using anticholinergics, tricyclic antidepressants, who have neurological disorders or urethral stricture. Men with complications such as radiotherapy will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-957zf2	Use of photoliasis and topical antioxidants in the treatment of actinic keratosis and skin cancer field: a randomized controlled trial	Recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3403	Use of photoliasis and topical antioxidants in the treatment of actinic keratosis and skin cancer field: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-957zf2	<NULL>	Sign the Informed Consent Form; Age between 50 and 90 years of both sexes; Present at least three and at most ten lesions clinically compatible with actinic keratosis in each forearm, bilaterally.	"Fewer than three or more than ten injuries in each forearm; Selected treatment area that has atypical clinical appearance or other extensive forearm dermatoses; Current and prior clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; Have hypersensitivity or allergy to any of the subtances under study; Patients using any systemic or topical immunosuppressive substance, oral retinoid, and other local treatments (eg corticosteroids, anti-inflammatory drugs, retinoids); Immunocompromised individuals; Coagulation disorders; Suspected or confirmed pregnancy. Note: Women of childbearing age should receive urinary Beta HCG at the beginning of treatment to exclude incipient pregnancy; Women of childbearing age who do not use contraception;
Breastfeeding women"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-8gmn4w	Evaluation of inflammation, bacterial concentration and lung strength in children and adolescents with Cystic Fibrosis and the effects of Curcumin supplementation	Recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3404	Evaluation of markers, microbiological and functions of children and adolescents with Cystic Fibrosis and the effects of Curcumin supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-15	Izabela Zibetti de Albuquerque	Hospital das Clínicas da Universidade Federal de Goiâs	https://ensaiosclinicos.gov.br/rg/RBR-8gmn4w	<NULL>	Subjects with Cystic Fibrosis; age between 04 and 18 years	Failure to perform spirometry; forced expiratory volume in the first second less than or equal to 40% of predicted	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7mzt6x	Acute effects of thoraco-lumbar Fascial Mobilization on tissue displacement, pain and function of individuals with Chronic Low Back Pain	Recruitment completed	Intervention	2020-01-27	<NULL>	<NULL>	3405	Acute effects of thoraco-lumbar Fascial Mobilization on tissue displacement, pain and function of individuals with Chronic Low Back Pain: crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7mzt6x	<NULL>	Young men and women over 18 years of age, with lower back pain for more than 3 months, with at least grade 4 pain on visual analogue scale analysis.	People with a history of previous or scheduled surgeries in the trunk or limb region; know or suspect severe fractures or pathology like tumor, inflammation or infection, rheumatologic disorder, aortic aneurysm, radiculopathy or neupathy with or without spinal cord stenosis with proven MRI, structural deformity of the spine, spondyloarthropathy, equine tail syndrome. limitation of significant movement or comorbidity, disabling pain and physical disability that makes the analysis impossible; use of analgesic or anti-inflammatory 48h before the tests; neurological or psychiatric disorder; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-4d9cv7	A Randomized Study with the use of Melatonin as Complementary Therapy to the Regimen of Analgesia and Sedation in Intensive Care: Analysis of Serum Levels	Recruitment completed	Intervention	2018-12-12	<NULL>	<NULL>	3406	A Randomized Study with the use of Melatonin as Adjuvant to the Analgesic Regimen in Intensive Care: Analysis of Serum Levels	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-25	Faculdade de Medicina de São José do Rio Preto - FAMERP	Faculdade de Medicina de São José do Rio Preto - FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-4d9cv7	<NULL>	Patients admitted to the ICU in the surgery postoperative, polytraumatized, with severe infection or sepsis, using analgesics and or sedatives, with the possibility of using the GIT within 48 h after admission to the ICU, both genders and above age of 18 years.	Patients considered unable to answer questionnaires, patients with a history of seizures, neurological or psychiatric diseases, sleep apnea, deaf or mute, with renal or hepatic failure, intestinal obstruction or other condition that would affect intestinal absorption, pregnancy, lactation and diseases autoimmune	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-6p37zr	Evaluation of the contribution of lupus in the distribution of statins to the liver.	Data analysis completed	Intervention	2020-01-27	<NULL>	<NULL>	3407	Evaluation of the effect of systemic lupus erythematosus on the activity of the OATP1B1 transporter using atorvastatin PK-PD.	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirào Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6p37zr	<NULL>	"Healthy Volunteers Group: no active chronic kidney disease; no clinical and laboratory evidence of inflammation; no diagnosis of lupus; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage).

Uncontrolled SLE Patients Group: SLEDAI scores between 6 and 12; no active chronic kidney disease; with clinical and laboratory evidence of inflammation; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage).

Controlled SLE patients group: SLEDAI scores between 0 and 5; no active chronic kidney disease; with clinical and laboratory evidence of inflammation; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage)."	History of severe chronic obstructive pulmonary disease; healthy patients or volunteers treated with MDR1, OATP1B1 and CYP3A inducers or inhibitors.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-98cknq	Effects of switched  training on the health of children and adolescents with chronic diseases	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3408	Effects of Cross Over Training on the health related physical fitness of children and adolescents with chronic diseases: a randomized clinical trial.	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2019-11-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-98cknq	<NULL>	Confirmed diagnosis of chronic diseases; patient with spina bifida;Duchenne muscular dystrophy;Charcot Marie Tooth;congenital dystrophy;congenital myopathy;independent walk; use assistive device;use of wheelchair; age between 8 to 16 year old;answer no to all PAR-Q questions; have less than two risk factors for coronary heart disease from the questionnaire;patients who could develop a maximum cardiopulmonary exercise test confirmed by physician;patients able to follow the instructions;patients with voluntary participation in the research	Patients with comorbidities associated with underlying disease that prevent maximum exertion;  recent upper limb fracture;history of hydrocephalus that compromises understanding or lead to neuromuscular changes and cause motor incoordination to perform the tests;children and adolescents whose guardians do not agree to sign the Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7y89kb	The impact of mindfulness on Quality of Life, Occupational Stress and Empathy of health professionals.	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3409	The impact of mindfulness on health professionals&apos; quality of life, anxiety, burnout levels and empathy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Pedro Henrique Leonetti Habimorad	Faculdade de Medicina de Botucatu (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-7y89kb	<NULL>	Voluntary health professionals working on the Clinical Hospital of the Botucatu Medical School (HC-FMB-UNESP); healthy	Health professionals working on administrative area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-35nvnj	Exploratory study to assess blood sugar control through the continuous use glucose monitor in patients with type 2 diabetes treated with basal insulin randomized to insulin glargine 300u / ml or glargine 100 u / ml been a 21 week single site study open with parallel arms	Data analysis completed	Intervention	2020-01-28	<NULL>	<NULL>	3410	Exploratory study to assess glycemic control through CGM in patients with type 2 diabetes treated with basal insulin randomized to insulin Glargine 300U / ml or Glargine 100 U / ml: a 21-week single site study with parallel arms.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2017-04-24	CPCLIN - Centro de Pesquisas Clinicas LTDA	CPCLIN - Centro de Pesquisas Clinicas LTDA	https://ensaiosclinicos.gov.br/rg/RBR-35nvnj	<NULL>	"Subjects with type 2 diabetes greater than 18 years of age with 1 or more oral antidiabetic agents (metformin and / or sulfonylurea) and NPH baseline insulin for at least 6 months;

HbA1c between ?7.5% and ?11%);

Capable and agreeing subjects to perform capillary glycemia;

Subjects who were able and who agreed to use CGM during the study;

Subjects who signed an Informed Consent Form."	"Under 18 years of age;

Subjects with type 1 diabetes mellitus

Subjects on an insulin regimen at baseline / bolus or pre-admixture or with another oral antidiabetic other than metformin or sulphonylurea.

History of hypoglycemia without symptoms.

Known hypersensitivity to insulin glargine or to one of its excipients

Carrier of any clinical condition including alcohol abuse or psychiatric condition) or known illness that prevents the subject from adhering to the protocol.

Use of systemic glucocorticoids for 2 weeks or longer than 12 weeks prior to screening (excluding topical or inhaled).

Pregnant or breastfeeding women

Women who do not want contraception.

Participants from another clinical study.

Subject with a history of cancer in the last 5 years except for basal cell cancer

Company employees

Night workers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-6hmh7w	Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Migraine	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3411	Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Chronic Migraine: Randomized Clinical Trial Placebo-Controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-15	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6hmh7w	<NULL>	Patients diagnosed with chronic aura and non-aura migraine headache, with pain intensity equal to or greater than 4 on the numerical pain scale, both sexes and aged 18 to 59 years.	Other dysfunctions with headache symptoms, history of head and neck trauma, cardiac pacemaker use, and have already used TENS. Also, if they are undergoing another type of physical therapy treatment or are starting a new medicine treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7h834x	Combined BCAA and Omega 3 Supplementation: Clinical-Nutritional, Cardiorespiratory, Metabolic Impact and Quality of Life in Pre-Malnourished / Malnourished Patients	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3412	Combined supplementation of Ramified Chain and Omega 3 Amino Acids: clinical-nutritional, cardiorespiratory, metabolic impact and quality of life in pre-cachectic / cachectic patients	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Maranhão	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-7h834x	<NULL>	Uterine Cervical Cancer; Minimum age of 20 years; Stability (no changes in treatment regimen within 6 weeks or hospitalizations within 3 months); Sign the consent form.	Restricted Vegetarian; Use of pacemaker; Palliative care; Withdrawal of Consent; Accession to intervention below 75%; Allergy Nutritional Composition of Supplements; Refusal of the proposed supplementation; Significant worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-4d4q42	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	Data analysis completed	Intervention	2020-01-28	<NULL>	<NULL>	3413	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Programa de Pós-graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4d4q42	<NULL>	To participate in the study, the elderly should meet the following inclusion criteria: male between 60 and 80 years old; do not exercise regularly and systematically for at least three months; do not present with musculoskeletal problems or cardiovascular complications that prevent physical exercises; present a medical certificate proving that you are fit for physical exercise; do not have a history of stroke or acute myocardial infarction; do not make use of smoking; not diagnosed with diabetes mellitus; do not exercise during the evaluation period; no pacemaker.	To exclude the study participant, he / she should: have some cardiovascular complication during the collections; not attending all evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-23vv4s	The effect of encouraging physical activity to quit smoking	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3414	Study to promote physical activity as a smoking cessation strategy: PROAFC	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-23	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-23vv4s	<NULL>	Smokers who smoke at least 5 cigarettes / day, over the age of 18, are clinically stable and have not had medication changes for at least 30 days, have a desire to stop smoking and participate in the anti-smoking program and individuals physically inactive according to physical activity level assessment.	Smokers who meet the following exclusion criteria will be excluded: individuals with pathological conditions that prevent physical exercise (orthopedic, neurological diseases, uncontrolled hypertension) and people who have lost more than 20 pounds in the last year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-2k94bn	"Comparison between Active Heat and Passive Heat Associated with Training
Posterior musculature flexibility passive"	Recruitment completed	Intervention	2020-01-28	<NULL>	<NULL>	3415	"Comparison between Active Heat and Passive Heat as Supporting in Training
Hamstring flexibility passive: randomized controlled trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-07	Universidade de Ciências da Saúde de Porto Alegre-UFCSPA	Universidade de Ciências da Saúde de Porto Alegre-UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-2k94bn	<NULL>	Active young women 18 to 30 years of age with restricted range of motion who had knee extension amplitude less than or equal to 160 degrees and hip flexion range less than or equal to 80 degrees	Previous neurological, muscular or joint disease that influences training performance; previous lower limb surgery; presence of painful symptoms or edema in the lower limbs; have hypersensitivity to heat application; Raynaud&apos;s syndrome; loss of local thermal sensitivity; have metal implants; use of cardiac pacemaker; presence of malignant tumor; arterial diseases; deep vein thrombosis or phlebitis; fever and inflammatory processes; bleeding processes; osteomyelitis; epilepsy; pulmonary and bone tuberculosis; kidney or urinary tract infection. Also excluded were subjects who had a training attendance lower than 85%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-9bdgxh	Comparison of quadriceps and hamstring muscle strength after exercise at 30% of maximal strength with and without peripheral vascular occlusion in the anterior cruciate ligament postoperative period: a randomized controlled trial.	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3416	Comparison of quadriceps and hamstring muscle strength after exercise at 30% of maximal strength with and without peripheral vascular occlusion in the anterior cruciate ligament postoperative period: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9bdgxh	<NULL>	Patients will only be included as participants if they agree to participate; sign the free and informed consent form authorizing their participation in the research; postoperative participants will be included in the study; with anterior cruciate ligament reconstruction; aged 18 to 65 years; men or women; diagnosis of anterior cruciate ligament rupture with planned surgery confirmed by medical examination;	No anterior cruciate ligament injury or reconstruction in the involved or uninvolved limb; patients requiring additional surgical procedures after anterior cruciate ligament reconstruction; infections in the operated region; complete dislocation of the knee;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-34vckp	Respiratory muscle training in patients with peripheral obstructive arterial disease	Recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3417	"Effect of respiratory muscle training on respiratory muscle strength, capacity
function and quality of life in patients with peripheral obstructive arterial disease"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-34vckp	<NULL>	Medical diagnosis; both sexes; age greater than or equal to 18 years; clinically stable with optimized drug therapy	Patients using walking aids; with cognitive disorders; with previous neurological disease; orthopedic problems that interfere with evaluations and interventions; urgent or elective surgical intervention during the protocol or six months before enrollment; pulmonary infectious process during protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-96xpfn	Evaluation of the effect of statin on post-treatment events in patients with Multibacillary Leprosy who were treated with the Oms / 12 doses scheme (Polychemotherapy)	Recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3418	Polychemotherapy in Patients with Multibacillary Leprosy Treated with OMS / 12 doses Scheme: Evaluation of Statin Effect on Events After Treatment	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2019-07-17	Instituto Oswaldo Cruz	Instituto Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-96xpfn	<NULL>	"multibacillary patients;
treated with the 12-dose MDT regimen with high therapy from June 2019 to April 2020;
age&gt; 18 years;
treatment for leprosy with discharge at the Souza Araújo Outpatient Clinic;
not being on statins for any reason;
non-immunosuppressive patients such as HIV-positive, ongoing neoplasms; established renal or hepatic impairment;
agree to participate in the project and sign the consent form."	"patients with active liver disease and / or unexplained persistent increase in transaminases on the requested tests;
patients with renal failure on the exams ordered;
pregnancy and lactation;
non-course patients need to use statistics other than simvastatin or simvastatin at a dose other than 40mg / day;
Known hypersensitivity to any component of the product."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-6np8nz	Evaluation and physiotherapeutic treatment of people with Spinocerebellar Ataxia.	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3419	Evaluation and treatment strategies for individuals with spinocerebelar ataxia (SCA)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-03	Centro Universitário Augusto Motta - UNISUAM	Centro Universitário Augusto Motta - UNISUAM	https://ensaiosclinicos.gov.br/rg/RBR-6np8nz	<NULL>	individuals of both sexes; aged 18 years and over; have received a clinical diagnosis of spinocerebellar ataxia provided by a neurologist from a DNA test; capable of walking 10 meters, with or without auxiliary device.	score ?18 on the Mini Mental State Examination; carriers of other neurological or orthopedic diseases that limit their activities; heart disease and / or uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-69qq9p	Biotin in the treatment of female hair loss	Not yet recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3420	A 24-week randomized, prospective, triple-blinded, placebo-controlled trial investigating the efficacy of 10 mg biotin in the treatment of chronic effluvium telogen in women	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-07-01	Paulo Ramos	Faculdade Medicina da Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-69qq9p	<NULL>	Inclusion criteria: women between the ages of 18 and 65 who complain of increased hair loss for more than six months; daily loss of yarn equivalent to at least level 5 of the Sinclair drop scale	Clinical or dermatoscopic signs of alopecia areata, trichotillomania or cicatricial alopecias; anemia (hemoglobin less than 11 mg / dl), thyroid changes (TSH&gt; 4.0 or &lt;0.3 um/L or T4l&gt; 1.5 or &lt;0.7 ng/dl); history of any treatment for hair loss in the last 3 months; surgery, pregnancy, febrile infectious disease or suspension of contraceptive use in the last 4 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-3jmx67	Balance rehabilitation with virtual reality exercise protocol in Neurological Diseases.	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3421	Vestibular Evaluation and Rehabilitation in Diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-02	Instituto Federal do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3jmx67	<NULL>	Patients aged 15 to 18 years; patients with hereditary spastic paraplegia (PEH); patients without musculoskeletal disorders.	Patients with otological alteration; patients unable to meet and understand simple verbal command; patients with visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-2ryhcv	Evaluation of blood microcirculation by cheek laser Doppler flowmetry in patients undergoing chemotherapy or radiotherapy	Recruitment completed	Observational	2020-01-29	<NULL>	<NULL>	3422	Laser Doppler Flowmetry evaluation in the genius region in patients undergoing antineoplastic therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-06-08	Universidade de São Paulo - Campus Bauru	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2ryhcv	<NULL>	"Diagnosis of malignant tumor;
Therapeutic regimen associated with high risk of developing oral mucositis. Standard chemotherapy and or head and neck radiotherapy;
Over age 18 years."	"Pregnancy;
Diabetic;
Smoker
Patients with uncontrolled blood pressure"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-5ztpqs	SHOW project: Sports practice for overweight students	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3423	Effects of a sports-based intervention on different health indicators of overweight students	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Gabriel Gustavo Bergmann	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-5ztpqs	<NULL>	Schoolchildren from the selected schools aged 08-12 years diagnosed with overweight and / or obesity	Schoolchildren with physical or intellectual disabilities. Importantly, if there are students with these characteristics, but who are authorized by their parents / guardians and wish to participate in the study, they will participate in all phases of the study (pre, post and intervention measures), and only their information is excluded. of the analyzes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-5j25nm	Comparison between Rotary and Manual Instrumentation for Root Canal Treatment in Children&apos;s Teeth	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3424	Comparison between Rotary and Manual Instrumentation in primary molar Biopulpectomies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5j25nm	<NULL>	"First or second lower deciduous molar with deep caries and pulp vitality that, on radiographic examination, showed pulp involvement;Teeth with painful or spontaneous painful symptoms that did not soften with the use of medication;Teeth with pain or absence of pain, which presented absence of hemostasis in adequate time (up to 5 minutes) after attempted pulpotomy, which macroscopically did not present reversibility characteristics;Absence of fistula or abscess;
Absence of bone thinning on radiographic examination;Absence of internal or external resorption of more than 2/3 of root;Restorative possibility of dental remnant"	Children with difficult behavior who did not cooperate with treatment; Children who have had systemic health problems; Teeth that had periapical lesion or interradicular bone rarefaction;Internal and / or external resorption involving more than 1/3 of the root length;Teeth less than 2/3 of root remnant;Disruption of the pericoronal sac of the permanent successor;Restorative impossibility; Teeth that had some previous pulp treatment;Patients who were taking antibiotics and / or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-4ct3ys	Influence of patient position on intra renal pressure during surgery to remove kidney stones	Recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3425	Influence of positioning on intrarenal pressure during percutaneous nephrolithotripsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-10	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-4ct3ys	<NULL>	Age over 18; Simple renal stone (computed tomography), defined as grade I and II on Guy&apos;s score, indicating percutaneous surgery.	Refusal; Pregnancy; Need for concurrent lateral or ureteral renal procedure; Cases where the ureteral catheter does not reach the renal pelvis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-35htgn	Evaluation of the permanence of the posterior fat to patella in the placement of the Total Prosthesis of the Knee	Data analysis completed	Intervention	2020-01-29	<NULL>	<NULL>	3426	The influence of preservation of retropatellar fat pad on the positioning of the tibial component in Total Knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-35htgn	<NULL>	Voluntary patients  above 55 years; both sexes; patients with osteoarthrosis primary	Patients with inflammatory joint disease; patients with a history of previous knee surgery and failure to undergo imaging.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-9kbgk2	Psychological intervention for women with fibromyalgia and insomnia	Recruitment completed	Intervention	2020-01-29	<NULL>	<NULL>	3427	Intervention in pain and insomnia in women with fibromyalgia in the postmenopausal period	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-20	Universidade Federal de São Carlos	Centro Universitário Central Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9kbgk2	<NULL>	Medical diagnoses of Fibromyalgia, diagnostic symptoms according to Wolfe criteria et al., (2010), and Insomnia Disorder identified according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, DSM-V-TR (2014) and actigraphy data (Octagonal Basic Motionlogger®, Ambulatory monitoring; Actwath-64®, Phillips Respironics).	The participants could not show other sleep disturbance identified by a health professional (e.g: Obstructive Sleep Apnea Syndrome, Restless Legs Syndrome), being on medication for sleep, or participating in psychotherapy during the period of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-894xfc	Minimally important difference in pain and menstrual symptoms in women with menstrual colic	Recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3428	Minimally clinically important difference for pain and menstrial symptoms in women with primary dysmenorreia: randomized clinical test	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-894xfc	<NULL>	Will be included in the project nulligravous women, aged 18 to 45 years, with symptoms of primary dysmenorrhea on at least one day of the menstrual period and at least 50% of cycles, with regular menstrual cycle, pain reported as moderate or severe. (NRS &gt;= 4).	Women with altered sensitivity, previous pelvic surgery, absence of symptoms in the last 2 cycles, or other associated pelvic symptoms will not be included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-97jc37	Oral assessment in autistic patients	Not yet recruiting	Observational	2020-01-29	<NULL>	<NULL>	3429	Oral condition assessment of patients with autism spectrum disorder	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-15	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-97jc37	<NULL>	Patients diagnosed with Autism Spectrum Disorder; Patients aged 5 and up to 15 years; Patients being monitored at the Center for Dental Assistance to Persons with Disabilities (CAOE).	Non-collaborating patients; Patients with unstable health condition; Patients with blood disorders; Active cancer patients; Patients in need of sedation; Patients supplemented with vitamins in the last two months; Edentulous patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-57pgws	Effectiveness of water with ozone mouthrinse in plaque formation and gingival inflammation: a crossover randomized clinical trial	Recruitment completed	Intervention	2020-01-30	<NULL>	<NULL>	3430	Effectiveness of ozonated water mouthrinse in early plaque formation and gingival inflammation: a crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-20	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-57pgws	<NULL>	Informed consent signed; age between 18 and 40 years old; do not smoke; good systemic health; availability of 21 days to participate in the two experimental periods and the washout between them; 20 natural teeth, including the anterior teeth (excluding third molars); do not have restorations on the incisors, canines and premolars; do not use fixed or mobile orthodontic appliances; do not present anatomical irregularities such as enamel cracks; do not present gingival recession; do not present gingivitis and/or periodontitis; not having used antibiotics or anti-inflammatories within 30 days prior to the beginning of the trial period; do not present allergy to the product used; not being pregnant or breastfeeding; do not present tumors in the oral cavity.	Serious adverse events related to intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-7qnprq	Clinical evaluation of new local anesthetics for oral application	Data analysis completed	Intervention	2020-01-30	<NULL>	<NULL>	3431	Efficacy and pharmacokinetics of new topical local anesthetic formulations for the oral mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7qnprq	<NULL>	Age 20 to 45 years; Healthy; Students form graduation or post graduation from Universidade São Francisco or Universidade Estadual de Campinas; only the subjects having the upper right canine free of caries, large restorations, periodontal disease, past endodontic treatment, oral mucosal with no trauma or sensitivity were included.	Allergy to local anesthetic; cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and hematological diseases, psychiatric disorders; use of any medication, except oral contraceptives one  week prior or during the experiment; smokers; addictive behavior with drugs or alcohol; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5hk245	The effect of Vitamin D use on dizziness treatment in elderly	Not yet recruiting	Intervention	2020-01-30	<NULL>	<NULL>	3432	The effect of Vitamin D supplementation on recurrence of Benign Paroxysmal Positional Vertigo in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Centro Universitário de Adamantina (UNIFAI)	Centro Universitário de Adamantina (UNIFAI)	https://ensaiosclinicos.gov.br/rg/RBR-5hk245	<NULL>	Benign Paroxysmal Positional Vertigo. Hypovitaminosis D. Elderly. Both sexes.	Those who do not agree with the study&apos;s prerogative, as well as non-collaborators, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-35mp4q	Study of the role of hydroxychloroquine in immunological and coagulation control  in patients diagnosed with Primary antiphospholipid syndrome	Data analysis completed	Intervention	2020-01-31	<NULL>	<NULL>	3433	Study of the role of hydroxychloroquine in immunomodulation and control of hypercoagulability in patients diagnosed with Primary antiphospholipid syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-11	Hemocentro- Universidade Estadual de Campinas	Hemocentro- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35mp4q	<NULL>	Confirmed diagnosis of primary antiphospholipid syndrome with thrombosis; age between 17 and 65 years old	Diagnosis of active neoplasia; presence of other associated autoimmune diseases; gestational period; antiphospholipid syndrome with isolated obstetric complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-4qfkt7	Phonological processing skills training (phonological awareness, working memory and rapid naming) and study of long-latency hearing potential (P300) in children with reading and writing difficulties	Data analysis completed	Intervention	2020-01-31	<NULL>	<NULL>	3434	"Study of Long Latency Auditory Evoked Potential (P300) pre and post intervention
on phonological processing in children with Reading and Writing Disorder"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	FAculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulos	https://ensaiosclinicos.gov.br/rg/RBR-4qfkt7	<NULL>	School children with diagnostic hypothesis of written language disorder (reading and writing problems); schoolchildren with neuropsychological diagnosis with upper and middle IQ; students attending the fourth, fifth, sixth or seventh grade of elementary school	Absence of consent of the responsible for the data collection; lower and lower average intelligence quotient; not attending school regularly; presence of syndromes that impair the cognitive part; presence or history of neurological disorders that impair cognition; hearing loss of some kind (conductive, sensorineural or mixed) or degree (mild, moderate, severe, profound) considering frequencies from 500Hz to 4000Hz; be in any therapy that involves learning and cognition (speech therapy, occupational therapy, psychopedagogy, tutoring, psychology or others)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-346ymn	Evaluation of mobile medical equipment called Tytocare that collects and sends patient data to other remote physicians for pediatric care even if they are not in contact with patients	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3435	Mobile medical device evaluation - Tytocare - for telemedicine validation through pediatric teleinter consultation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-20	Hospital Pequeno Principe	Hospital Pequeno Principe	https://ensaiosclinicos.gov.br/rg/RBR-346ymn	<NULL>	Patients between 0 and 18 years incomplete; both sexes; attended at the SUS Emergency Service or agreement; classified in green code (low risk) in the HPP Emergency Care screening; a parent or legal guardian consents to and signs the Informed Consent Form	Patients classified in the codes red (severe patient, considered as emergency, with immediate care), orange (patient considered as urgent, with care within 15 minutes), yellow (patients who do not have conditions that characterize medical urgency, however , are identified as patients who require particular conditions for prioritization) and blue (patients who have specific procedural needs); Patients whose legal guardian or parent does not consent to participate; Patient who does not agree to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-48g9q6	Evaluation of 2 types of maxillary expanders: bone, dental and periodontal changes	Recruitment completed	Intervention	2020-01-31	<NULL>	<NULL>	3436	Evaluation of rapid maxillary expansion effects with tooth-borne and tooth-bone-borne expanders: skeletal, dental and periodontal alterations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-02	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-48g9q6	<NULL>	Patients with maxillary transverse deficiency; unilateral or bilateral posterior crossbite; aged 11 to 14 years; male and female;  patients should have no cleft lip; patients must be in the permanent denture phase.	History of previous orthodontic treatment; presence of systemic diseases; presence of congenital deformity; loss of permanent teeth or agenesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-32jnbm	Study of the effects of the fractional radiofrequency and  microneedling in long-term on the outer region of the vagina in menopausal women	Not yet recruiting	Intervention	2020-01-09	<NULL>	<NULL>	3437	Evaluation of long-term effects of fractional radiofrequency and microneedling on external genitalia in menopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal do Rio Grande do Norte	Instituto Patrícia Froes	https://ensaiosclinicos.gov.br/rg/RBR-32jnbm	<NULL>	In the inclusion criteria, participants must be between 55 and 65 years of age, with flaccidity in the vulvar region, post-menopausal period of up to 5 years, who had 2 to 3 normal births, not practicing physical activity, not being able to use hormone replacement therapy and with the ability to understand and preserve local sensitivity.	Exclusion criteria will apply to all participants who are pregnant, breastfeeding 3 months before treatment or planning to become pregnant during the study period, with active sexually transmitted disease, acute bacterial or viral infection, pacemaker carriers or other implanted electrical devices, malignant tumor, weakened immune system, collagen diseases, continuously using anti-inflammatory drugs, dermatological condition that requires systemic or topical therapy in the area of treatment and metallic implants. Participants who do not agree with the procedures, have a sensitivity disorder during therapy, or do not adapt to the schedules and procedures will be discontinued from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8kfr58	Evaluation of the seroma wound infection wound dehiscence skin graft failure rates in the case studies of the CNMR.	Terminated	Observational	2020-01-31	<NULL>	<NULL>	3438	Assessment of the incidence and risk factors of surgical complications in patients with non-metastatic MELANOMA from the case study of the CNMR(Registro Nacional Clínico de Melanoma)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	veneto institute of oncology	veneto institute of oncology	https://ensaiosclinicos.gov.br/rg/RBR-8kfr58	<NULL>	Age greater than 17 and equal or smaller of 70;histological confirmation of melanoma;no treatment for melanoma before biopsy surgery.	Patients with pigmented lesions with histology other than melanoma;age smaller than 17 years and greater than 70 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-9hszzh	Clinical and antimicrobial effect after use of Brazilian red propolis toothpaste	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3439	Avaliação de dentifrício de própolis vermelha brasileira sobre redução de bactérias orais e gengivite em adolescentes em tratamento ortodôntico	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9hszzh	<NULL>	Aged between 12 and 18 years; Use of fixed orthodontic appliance; Presence of visible plaque on dental surfaces; Presence of gum bleeding Be right handed	"Present systemic changes related to the periodontal health-disease process;
They underwent antimicrobial therapy (antibiotic and / or anti-inflammatory treatment) up to six months before the research;
Licit / illicit drug users;
Are prosthesis wearers;
Carriers of less than 10 dental elements per dental arch;
Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis);"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-7vh96h	Effect of Physiotherapy on Muscular Force and Quality of life in patients who have Surgery of the Heart	Recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3440	Effect of Peripheral Muscular Training on Muscular Force, Functional Capacity and Quality of Life in individuals after Coronary Artery Bypass Graft	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Universidade Federal de Alfenas	Hospital Santa Lúcia de Poços de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-7vh96h	<NULL>	Volunteers with coronary artery disease; adults between 18 and 80 years; of both sexes.	Volunteers presenting with postoperative complications; with osteomuscular sequelae of stroke; osteomuscular sequelae that compromise the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8pd5zr	Evaluation of Glycemic Variability and Hypoglycemic Episodes in type 2 Diabetics with Important Decrease of Renal Function	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3441	Evaluation of Glycemic Variability and Hypoglycemic Episodes in type 2 Diabetics with Chronic Renal Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8pd5zr	<NULL>	Men or women over 18 years; Advanced kidney disease undergoing renal replacement therapy; Type 2 diabetes mellitus on NPH insulin treatment with or without regular insulin for at least 3 months; Glycated hemoglobin greater than 6.5%	Type 1 diabetes mellitus; hypersensitivity to research drugs; treatment with oral glucocorticoids; cancer; women of childbearing age who are pregnant or wish to become pregnant; participation in any other clinical study within the last 90 days prior to the start of this study; abuse of narcotics or alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-87m8qg	Canal Treatment of deciduos teeth Antibiotics Creams	Recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3442	Pulp Therapy in deciduos molars using Antimicrobial Pulps: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-87m8qg	<NULL>	Children previously authorized by their parents to take part in the study through the Informed Consent Term (TCLE); Children aged 6 to 7 years; Children with satisfactory systemic health and who do not use continuous systemic medication for the treatment of acute or chronic diseases; Children who do not have any type of syndrome; Children who have at least one non-vital deciduous molar;	Non-restorable deciduous molars or perforation on the pulp floor;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8fdnky	Bulk fill composite resins	Recruiting	Intervention	2018-05-09	<NULL>	<NULL>	3443	Bulk fill composite resins: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-02	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8fdnky	<NULL>	All included patients will require at least five class I or II restorations in molars or premolars. The causes for composite resin restorations in this study may be fractures, large misalignments or other defects in existing amalgam restorations, or replacement of amalgam restorations for aesthetic reasons. In that case, the request must be made by the patient. Patients must be at least 18 years. Patients should have good general health, acceptable oral hygiene and availability of return during the evaluation periods. All teeth included in the study should have a normal occlusal relationship with the natural antagonist tooth, at least one contact with the adjacent tooth and those with marked occlusal stress, evidenced by severe occlusal wear, will be excluded. The cavities may involve enamel and dentin and should have a minimum depth of 3 mm.	Pregnancy or breastfeeding, non-vital tooth, allergies and idiosyncratic responses to product ingredients, occlusal contactless tooth with or without proximal contact, orthodontic treatment for less than 3 months, history of existing tooth sensitivity, prosthetic teeth fixed or removable, periodontal surgery performed less than 3 months ago, teeth or supporting structures with any painful pathology, bruxism, periodontal disease, known allergy to resinous materials, cavities to be restored shallow and / or narrow, impossibility to return to the recalls , fractured or visibly cracked teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-37r3s2	Vocal and Communication Skills for Public Speaking in University Students	Data analysis completed	Intervention	2018-09-13	<NULL>	<NULL>	3444	Promotion of Vocal and Communication Skills for Public Speaking in University Students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-37r3s2	<NULL>	Undergraduate students; ages between 18 and 30 years old; signed informed consent form	The following are excluded  from the sample: individuals who regularly practice an activity which involves speaking in public (work with public attending, attend to regular group reunions, etc.); individuals with previous training (oratory courses or similar); individuals who possess a psychological or medical diagnosis of social anxiety disorder or social phobia; present accentuated hormonal alterations, known or during the tests; present a frequency of less than 75% in the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-4q4kb5	Assessment of bladder location using ultrasound after physiotherapy treatment in women with loss of urine	Recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3445	Bladder Neck Mobility after Physiotherapeutic Intervention in Women with Stress-Urinary Urinary Incontinence: A Randomized Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4q4kb5	<NULL>	Inclusion criteria for selection of the sample are female, between 40 and 50 years of age, have significant urinary loss through physical exertion, proven by the pad test and have a bladder lowering.	The criteria for exclusion in the study will be pregnancy, urinary tract infections, neurological diseases, total hysterectomy, metal implants, pelvic tumors and clinical and / or surgical treatment for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-3dbmqs	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity	Not yet recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3446	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity: Crossover Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-3dbmqs	<NULL>	Participants of either sex aged greater than 18 years but less than 60 years; Professional or semi-professional athletes practicing physical activity at least 2x / week for more than 6 months; Signed informed consent; Completion of modified physical activity readiness (Par-Q) and global physical activity fitness (GPAQ) questionnaires; Able to use a treadmill.	Present with signs or symptoms of acute or chronic illness; Athletes with an initial core temperature less than 35.5 or greater than 37.5 °C; BMI greater than 30 kg/m2; Skin lesions evident or reported by athletes or medical staff that contraindicate participation in the study, such as purulent skin gangrene; Known joint and/or muscle injuries that contraindicate the use of a treadmill; Have contraindications to cryotherapy such as cryoglobulinemia, cold intolerance, Raynaud&apos;s disease, hypothyroidism, acute respiratory system disorder, cardiovascular disease (unstable angina or CHF class III and IV), sympathetic nervous system neuropathy, local blood flow disorders, and cachexia; Current participation in another ongoing clinical trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5vyd2x	Evaluation of the use of Mirena IUD  in patients with increased uterine bleeding with blood clotting disorders.	Data analysis completed	Intervention	2020-02-03	<NULL>	<NULL>	3447	Evaluation of the use of the Levonorgestrel-releasing Intrauterine Device to control Abnormal Uterine Bleeding in patients with hereditary coagulopathy.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Medicina-Universidade Federal de Minas Gerais	Faculdade de Medicina-Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5vyd2x	<NULL>	Participants were women previously diagnosed with inherited coagulopathies presenting excessive menstrual bleeding	Myomatosis; use of anticoagulants; uterine malformations; contraindications to the use of levonorgestrel device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5b6zrg	Expansion of preschoolers food universe: intervention study	Recruitment completed	Intervention	2020-02-03	<NULL>	<NULL>	3448	Stimulus to healthy food consumption and the expansion of the food universe during early childhood: intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-02	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5b6zrg	<NULL>	Children aged 4-6 enrolled in the selected preschools.	Children with dietary restrictions and under specific diets.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-98f3j9	Use of a Calotropis procera latex protein biomembrane for the treatment of foot wounds in people with type 2 diabetes mellitus: randomized clinical trial	Recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3449	Use of a Calotropis procera latex protein biomembrane for the treatment of plantar ulcers in people with type 2 diabetes mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade Metropolitana da Grande Fortaleza	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-98f3j9	<NULL>	Previous diagnosis of type 2 diabetes mellitus; Presence of perforated plantar ulcer with an area smaller than 24 cm². In cases of patients with more than one ulcer, the largest diameter will be chosen as the reference ulcer for the evaluation measures; Male or female research subjects aged 18 or over and 65 or under; Able to understand the nature and purpose of the study, including risks and adverse effects and with the intention of cooperating with the researcher and acting in accordance with the requirements of the entire trial.	Those patients who obtain a positive response to any of the following criteria will be excluded from the study will exclude the research subject from the study: Research subject who has known hypersensitivity or related compounds; history of serious adverse reactions; Presence of peripheral obstructive arterial disease; Drug addiction, including alcohol; Infection in the ulcer diagnosed at the time of recruitment or during the development of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-9jk2yh	"Effect of FortiFit PRO® supplement associated with resistance exercise and diet
in muscle function of independent elderly
with loss of muscle mass"	Recruiting	Intervention	2020-02-05	<NULL>	<NULL>	3450	"Effect of FortiFit PRO® supplement associated with resistance exercise and diet
in muscle function of independent elderly
with Sarcopenia"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Ibramep - Instituto Brasileiro de Medicina e PEsquisa	Ibramep - Instituto Brasileiro de Medicina e PEsquisa	https://ensaiosclinicos.gov.br/rg/RBR-9jk2yh	<NULL>	"Age over 65 years; Gender: female and male
3) Sarcopenia according to the diagnostic criteria of EWGSOP2: Sarc-F questionnaire: score greater than or equal to 6; Handgrip test (grip strength): men under 27kg, women under 16kg or Stand up / sit test: more than 15 seconds for 5 climbs; skeletal musAgecle mass: men less than 20kg, women less than 15kg or skeletal muscle mass / height2: men less than 7.0 kg / m2; women less than 5.5 kg / m2
- SPPB tests: score greater than 8; Sedentary lifestyle; Independent in relation to activities of daily living (score greater than or equal to 46 on the modified Barthel index)
Rely on support persons (family members or external staff) to assist in following the diet and study recommendations; Having provided written consent to participate in the study, confirmed by signing the Informed Consent Form."	Creatinine clearance less than 35 mL / min; Use of nasogastric tube or gastrostomy; Bedridden patients; Parkinson&apos;s disease; Type 1 diabetes, chronic kidney disease; Severe heart diseases; Other clinical conditions that may, according to medical criteria, make physical exercise and / or food supplementation unfeasible with FortiFit PRO®; Vitamin D level less than 20ng / ml at the end of the run-in period; BMI greater than or equal 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-3mr2vm	Effectiveness of abdominal compression maneuver on neck vein distention and its influence on intra-abdominal pressure and on cardiac functioning of mechanically ventilated children	Data analysis completed	Observational	2019-10-10	<NULL>	<NULL>	3451	Effectiveness of hepatic compression maneuver on internal jugular vein distention and its influence on intra-abdominal pressure and cardiac index of mechanically ventilated children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital das Clínicas da Universidade Estadual de Campinas	Hospital das Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3mr2vm	<NULL>	Age between 28 days and 14 years old; need for central venous catheterization due to the clinical condition that justified the hospitalization; presence of bladder catheter that allows IAP measurement; patients with clinical criteria for IAP monitoring due to the risk of abdominal hypertension caused by the disease that justified their hospitalization; patients under invasive mechanical ventilation with tidal volume between 8 and 10 ml / kg of ideal weight and mean airway pressure between 8 and 12 cmH20; hemodinamically stable patients defined as age-appropriate heart rate and blood pressure (between the 10th and 90th percentiles); patients with respiratory stability defined as age-appropriate respiratory rate and arterial O2 saturation greater than 94% as measured by pulse oximetry; availability of the researcher responsible for performing the ultrasound exam.	Previous venous thrombosis in internal jugular veins; presence of collateral venous circulation in the cervical region in patients with a history of previous internal jugular vein catheterizations; Initial intra-abdominal pressure greater than 12 mmHg; peritoneal dialysis; skin lesions in the right upper quadrant of the abdomen; skin lesions in the cervical region; continuous dobutamine infusion at doses greater than 5 mcg / kg / min, adrenaline at doses greater than 0.1 mcg / kg / min, noradrenaline at doses greater than 0.1 mcg / kg / min, or milrinone at doses greater than 0.25 mcg / kg / min; intense psychomotor agitation impairing ultrasound examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8yxz44	Evaluation of condylar position, angulation and morphology in patients submitted to surgery orthognathic surgery	Data analysis completed	Intervention	2020-02-06	<NULL>	<NULL>	3452	Evaluation of position, angulation and morphological aspects of the condylar process in patients submitted to surgery	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-18	Faculdade de Odontologia de Araraquara - FoAr - Unesp	Clinica de Radiologia Odontologica Radio.com	https://ensaiosclinicos.gov.br/rg/RBR-8yxz44	<NULL>	patients older than sixteen years; second to second molars present in both arches; and in need of orthognathic surgery with previous orthodontic preparation.	patients with craniofacial anomalies; systemic arthritis; muscular diseases; history of facial trauma; previous TMJ surgery; facial asymmetry; severe condylar bone resorptions; immunological diseases; pathologies that can cause condylar hyperplasia and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-7w5kkx	"Evaluation of the effectiveness of photodynamic 
therapy in conventional periodontal therapy: clinical trial"	Recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3453	Evaluation of the effectiveness of Photodynamic Therapy in non-surgical Periodontal Therapy: randomized clinical trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-31	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Pró-reitoria de pesquisa - PRPQ	https://ensaiosclinicos.gov.br/rg/RBR-7w5kkx	<NULL>	Individuals over 18 years of age; both sexes; with at least 12 teeth; with generalized chronic periodontitis; teeth affected by periodontitis in the four quadrants.	Individuals submitted to periodontal treatment or submitted to antibiotic therapy in the last 3 months; smoking; pregnant and lactating women; use anticoagulant medication; (HIV) positive; and that present systemic conditions as a risk factor for periodontitis or have contraindication to the periodontal clinical examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8y8b45	Effect of a health guidance program on decreasing muscle complaints in workers who use the computer for long periods	Recruitment completed	Intervention	2020-02-06	<NULL>	<NULL>	3454	Effect of a health education program on reducing musculoskeletal complaints in long-term computer workers: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-09	Centro Universitário Cesmac	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-8y8b45	<NULL>	Active worker volunteers who use computers for at least four hours a day; both sexes; age between 18 and 59 years.	Pregnant volunteers; Volunteers reporting musculoskeletal pain or injury due to infectious, genetic or traumatic disease and / or disorder; Volunteers who have a physical or mental disability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-4fvrqx	"Effects of maxillary advancement with facial mask on Class III orthopedic treatment
between patients with and without cleft lip by tomographic comparison"	Recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3455	Effects of Maxillary Protraction with Facemask on Class III Orthopedic Treatment between patients with and without Complete Unilateral Cleft Lip and Palate through Tomographic Comparison	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4fvrqx	<NULL>	"Group I: Individuals with complete and unilateral cleft lip and palate between 5 and 13 years of age;occlusal indexes Goslon 3, 4;
Agree to participate and sign the free and informed consent form
Group II: Individuals with deciduous dentition or in the 1st transitional period of mixed dentition; agree to participate and sign the free and informed consent form"	Patients who do not perform the requested exams; patients who do not return to reevaluation appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-557ngk	Effects of Melatonin supplementation and Physical Exercise practice on aged individuasl with Muscular Weakness	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3456	Effects of Melatonin supplementation on Sarcopenic aged individuals submitted to a Physical Exercise program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-557ngk	<NULL>	Age between 55 and 80 years; both genders; diagnosis of sarcopenia	Present an orthopedic disorder that contraindicates physical activities; cognitive disorder that makes it difficult to orient the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8sdrvb	Training Effectiveness Using Complementary Video Game for Rehabilitation in PET / MAH Patients: Randomized Trial	Recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3457	Efficacy of Virtual Reality Training as a Complement to Rehabilitation in PET/MAH Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Núcleo de Medicina Tropical	Núcleo de Medicina Tropical	https://ensaiosclinicos.gov.br/rg/RBR-8sdrvb	<NULL>	Have the confirmed diagnosis of PET / MAH, by an infectologist; refer to mild pain or acute second visual analogue scale (VAS); gait alteration (claudication, use of orthoses as a cane or crutch) and age range between 30 and 60 years.	Have less than 6 months of PET / MAH diagnosis; have any other neurological diagnosis; use wheelchair; being physio-therapeutic treatment concomitantly to the period of the research; does not meet the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-53pppb	Fluoride availability in saliva after brushing with embedded Brazilian red propolis toothpaste	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3458	Evaluation of fluoride in saliva after using toothpaste incorporated with Brazilian red propolis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-53pppb	<NULL>	"Be right handed
Normosystemic
Good oral health conditions
Both genders
Aged between 12 to 18 years"	"Present systemic changes related to the periodontal health-disease process
They underwent antimicrobial therapy (antibiotic  or anti-inflammatory treatment) up to six months before the research;
Licit or illicit drug users
Are prosthesis wearers
Patients with missing teeth
Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis)
Patients with a history of hypersensitivity to medication, food or other factors
Patients with a history of chronic diseases
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-774xbd	Effect of a homemade salivary substitute prepared with Chamomile and Linseed in relieving the burning sensation in the mouth	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3459	"Effect of a homemade salivary substitute based on Chamomile (Matricaria chamomilla) and
Linseed (Linum usitatissimum) in relieving the symptoms of Burning Mouth Syndrome"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-20	Faculdade de Odontologia Universidade Federal de Pelotas	Faculdade de Odontologia Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-774xbd	<NULL>	Women over 40 diagnosed with BMS by an oral medicine specialist according to the international classification of headache disorders; complaining of an intraoral burning sensation for more than 2 hours for more than three months; clinically normal oral mucosa; without signs of neuropathies involving other pathologies; without articular function; normal blood samples (red blood cell and leukocyte count, C-reactive protein levels, normal levels; no anemia); in the case of previous treatment for BMS it must have been included ineffective and discontinued for a minimum period of 2 months before being included in the study	Women with oral lesions or systemic diseases associated with BMS; Women in current treatment for BMS; Women with a glycated hemoglobin level (hemoglobin A1C)&gt; 7%; pregnant women; women being treated with corticosteroids; women with lesions in the oral mucosa or patients with dental prosthesis; women with anemia, Sjoegren&apos;s Syndrome or another Autoimmune Diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-78bn48	"WINE Study - Strength and flexibility
training for pain reduction and work
performance improvement"	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3460	Effects of an exercise protocol for work-related musculoskeletal disorders on grape collectors in the São Francisco Valley	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78bn48	<NULL>	Physically independent participants who have not participated in structured exercise programs for at least 3 months will be included in the study. In addition, absence of clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise during pre-participation screening; history of lower back pain lasting more than one week; pain greater than 3 on the pain perception scale (0 to 10 points) in the lumbar spine; have no history of trauma or surgery in the lumbar spine; no spinal and knee disorders that make it impossible to perform exercises, no hypertension, cardiovascular disease, heart failure, myocardial infarction and cerebrovascular accident, are inclusion criteria.	"Performing any type of exercise for the
spine during the intervention period
or engaging in another physical activity
program; continuous use of drugs and / or
ergogenic resources that positively or
negatively interfere with performance;
participants affected by limiting health
conditions; and pregnancy during the
intervention period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3rh759	Development of a Health Promotion Program for patients with Fibromyalgia	Not yet recruiting	Intervention	2020-02-07	<NULL>	<NULL>	3461	Development of an Interdisciplinary Health Promotion Program for People with Fibromyalgia - Fribro&apos;s Friends	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rh759	<NULL>	Individuals of both sexes; age equal to or over 18 years; with medical diagnosis of fibromyalgia confirmed by an evaluator according to the Classification Criteria of the American College of Rheumatology revised version of 2016; individuals with preserved speech and hearing ability.	Medical diagnosis of myofascial pain syndrome; extra-articular rheumatism affecting several areas; polymyalgia rheumatica and giant cell arthritis; polymyositis and dermatopolymyitis; tendinopathies; neuropathies; endocrine myopathies; hypothyroidism; hyperthyroidism; hyperparathyroidism; adrenal insufficiency; metabolic myopathy due to alcohol; neoplasms; spinal diseases; Parkinson&apos;s disease; pregnant and lactating women; individuals who have not taken medication for more than three months or with stable pharmacological treatment (more than 3 months); individuals who are absent more than twice in a row in the intervention group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7rqxry	Evaluation of Behavioral and Psychological Symptoms in older people with Dementia: Psychoeducational Intervention in caregibers in Nursing Home	Recruitment completed	Intervention	2020-02-09	<NULL>	<NULL>	3462	Evaluation of Behavioral and Psychological Symptoms in Dementia: Psycho-Educational Intervention in caregivers in Long-Term Permanent Institutions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-7rqxry	<NULL>	Individuals aged 18 to 60 years; working in the long-term care facility for the elderly for at least 3 months; both genders; agree to participate in the research after completing the Informed Consent Form	Individuals who do not understand the questions contained in the protocol; do not accept to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-6zk87m	Brief Group Intervention to reduce alcohol use in men	Data analysis completed	Intervention	2020-02-09	<NULL>	<NULL>	3463	Brief group intervention to reduce alcohol use in men: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-25	Escola de Enfermagem Universidade de São Paulo	Escola de Enfermagem Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zk87m	<NULL>	Men be over 18 years of age; who know how to read and write; and that they score AUDIT between 8 and 19.They should be classified as well risk use or harmful use of alcohol.	Being in treatment or attending a group related to the use of alcohol; be a carrier of cognitive disability that impedes the understanding of the terms of the research; being intoxicated or under the effect of some psychoactive substance; not have a telephone or home address.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-252w9r	Minoxidil 5 mg oral versus Minoxidil 5% topical solution for Male Pattern Baldness: randomized clinical trial	Not yet recruiting	Intervention	2020-02-09	<NULL>	<NULL>	3464	Minoxidil 5 mg oral versus Minoxidil 5% topical solution for Treatment of Male Androgenetic Alopecia: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-252w9r	<NULL>	"We will select ninety male patients aged between 18 and 55 years with the diagnosis of male androgenic alopecia, classified in the Norwood Hamilton scale as 3V, 4V or 5V, informed and agreeing to participate in the research.
The diagnosis of male androgenic alopecia will be based on clinical, dermoscopic and histopathological criteria."	Patients who have had previous hair loss treatment in the last 6 months, hypertensive patients, heart disease, nephropaths, other causes of hair loss or scalp dermatosis will not be eligible to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-233bct	Biomarkers and clinical scores in critically ill patients at the emergency department	Recruiting	Observational	2020-02-10	<NULL>	<NULL>	3465	Biomarkers and clinical scores in critically ill patients at the emergency department	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Fundação de Amparo a Pesquisa do Estado de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-233bct	<NULL>	Volunteers; Admitted to the Emergency Department for any acute illness; Patients hospitalized for less than 24 hours; Patients over 65 years	Hospitalization for exclusive palliative care or end-of-life care; Expected hospital stay less than 48 hours; Hospitalization for less than 30 days; Refusal of the patient or his representative to sign an informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8x52jd	Study of analysis of pain improvement in patients with sacral pain who underwent interventional procedure in pain with the radiofrequency technique.	Other	Observational	2020-02-10	<NULL>	<NULL>	3466	Retrospective study of the analgesic effect of denervation of sacroiliac joints with radiofrequency in patients with sacral pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Ligia Ferreira de Toledo Kawamoto	Ligia Ferreira de Toledo Kawamoto	https://ensaiosclinicos.gov.br/rg/RBR-8x52jd	<NULL>	"The study will be done with approval by the Ethics Committee of the Hospital Vera Cruz and the Federal University of São Paulo. Data from the medical records of patients submitted to radiofrequency for lumbar pain in unilateral or bilateral sacroiliac joint from January 2015 to December 2017 will be collected.
Will be collected from the medical records:
Patient data: age, sex, height, weight
Pain characteristics: location, duration, intensity, start time. Previous treatments
Medications in use for pain and dose
Relief of pain after radiofrequency denervation (X scale), evaluated for X months.
Need for medication or other techniques for pain relief after radiofrequency. Adverse effects and complications"	Patient not submitted only procedure of denervation of the sacroiliac joints with pulsed radiofrequency, conventional or refrigerated techniques.Patients who were not submitted to the procedure from January 2015 to December 2017.Excluded medical records that did not have all the information studied	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-2ypzfw	Follow-up of dental implants in patients with hereditary coagulopathies	Recruiting	Observational	2020-02-10	<NULL>	<NULL>	3467	Assessment of students&apos; and professionals&apos; knowledge and the psychological aspects, dental needs and treatment and follow-up of dental implants in patients with hereditary coagulopathies	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-2ypzfw	<NULL>	To be included in the sample, patients will need to have any of the following characteristics: Be over 18 years old; Have an indication of dental implants; have hemophilia A; have hemophilia B; Having von Willebrand&apos;s disease.	Patients with any of the following characteristics may not be part of the sample: Patients with any systemic disease that prevents surgery for dental implant installation; Patients who do not have time available for care at the institution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-25t5xj	The effect of Lidocaine 1% use on Preemptive Analgesia in varicocele surgery	Recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3468	Efficacy of 1% Lidocaine infiltration in Preemptive Analgesia in Microsurgical Varicocelectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-29	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-25t5xj	<NULL>	Adults up to 50 years of age and with indication for unilateral varicocelectomy.	Presence of other testicular pathologies; Other concomitant surgeries; Chronic or recent use of analgesics, antidepressants, corticosteroids, alcohol or other recreational drugs; Psychiatric disorders that prevent reliable subjective assessment of pain; Relapsed varicocele; Morbid obesity; Diagnosis of pain syndromes (fibromyalgia, chronic pelvic pain, myofacial syndrome); Allergy to local anesthetics, anti-inflammatories and opioids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-97mffm	A randomised controlled trial of a smartphone application for help oral hygiene	Not yet recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3469	Mobile Health (mHealth) Intervention assessment for the treatment of periodontal diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Programa de Pós Graduação em Odontologia da Universidade Federal do Rio Grande do Sul	Mirian Paola Toniazzo	https://ensaiosclinicos.gov.br/rg/RBR-97mffm	<NULL>	"To be included:
volunteers with gingivitis and periodontitis;
non smokers;
both genders;
age between 18 and 60 years;
 Individuals must have their own cell phone handset with internet access;
be literate in mHealth;
have a visible plaque percentage greater than or equal to 30%;
have a percentage of gingival bleeding greater than or equal to 30%;
Clinical insertion loss greater than or equal to 3 mm in two nonadjacent teeth;
bore depth greater than or equal to 4 mm in two or more teeth;
At least 12 teeth present."	"The following exclusion criteria will be considered: 
patients who used antibiotics or anti-inflammatory drugs in the last 6 months prior to the study; 
who have any physical condition that impairs their motor skills; 
who are wearing orthodontic braces; 
 smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-2kmyfm	Use of Follitropin Delta associated with Menotropin to induce ovulation in high-risk patients for Poor Response in In Vitro Fertilization	Not yet recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3470	Follitropin Delta plus Menotropin for Ovarian Stimulation during In Vitro Fertilization treatments in patients at risk of ovarian poor response: a prospective clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-03-01	Clinica Vidabemvinda	Clinica Vidabemvinda	https://ensaiosclinicos.gov.br/rg/RBR-2kmyfm	<NULL>	"Informed consent signed before starting the treatment cycle; Good physical and mental health; Pre-menopausal women aged at least 18 and at most 40 years of age when they sign the consent form and when they start the treatment cycle, in that order; Infertile women diagnosed with tubal, unexplained infertility, endometriosis stage I or II or whose partners have a male factor and are eligible for IVF or intracytoplasmic sperm injection (ICSI) using fresh or frozen semen from the partner or donated; Infertility of at least one year before the start of the study for women up to 37 years old and for at least 6 months for women aged 38 years or more (not applicable if there is already known tubal or male factor);
The cycle included should be the individual&apos;s first controlled ovarian stimulation cycle for IVF;Regular menstrual cycles lasting between 24 and 35 days, presumably ovulatory; Hysterosalpingography, hysteroscopy, hysterosonography or transvaginal ultrasound documenting uterus with anatomy compatible with pregnancy (that is, without evidence of submucosal or intramural uterine fibroids larger than three centimeters, polyps or congenital anomalies that are associated with reduced chances of pregnancy within one year before the start of the study);Transvaginal ultrasound documenting the presence of both ovaries in an accessible position for egg collection, without clear evidence of other normalities (that is, endometriomas larger than three centimeters or ovaries of very large volume that contraindicate the use of gonadotropins) and normal attachments (that is, without hydrosalpinx) within one year before the start of the study; Serum FSH levels in early follicular false (from the second to the fourth day of the cycle) between 1 IU per L and 15 IU per L, obtained within three months of the beginning of the study; Negative serologies for HIV, HTLV, Hepatitis B (surface antigen and anti-core), Hepatitis C and syphilis, within 6 months of the beginning of the study and Zika virus in the month of the beginning of the cycle; Body mass index between 17.5 and 32 kg per square meter (including both values) at the beginning of the study; Availability to accept a transfer of up to two blastocysts originating from the study cycle within one year after inclusion"	"known stage III or IV endometriosis;
One or more follicles greater than or equal to 10 mm on the day the stimulation starts; History of recurrent miscarriage (three consecutive losses before 24 weeks, excluding ectopic pregnancy); Abnormal karyotype of the woman or partner or semen donor. In cases where the seminal analysis shows a concentration below one million sperm per mL, a Y chromosome microdeletion test with normal results is mandatory; Any significant systemic clinical disease (eg, insulin-dependent diabetes); Any known hereditary or acquired thrombobophilia; Active arterial or venous thromboembollism or severe thrombophlebitis, or history of these events; known porphyria; Any endocrine-metabolic disease (pituitary, adrenal, liver, pancreas and kidney) that may compromise participation in the study, with the exception of well-controlled thyroid disease; Presence of known anti-FSH antibodies (based on history and previous tests and not on tests performed during that study); Known tumors of ovary, breast, uterus, adrenal, pituitary or hypothalamus that contraindicate the use of gonadotropins; Impaired kidney or liver function; Current lactant; Abnormal vaginal bleeding without a definite cause; Abnormal cervical oncotic cytology within three years of the start of the study (unless already treated and resolved); Findings of gynecological exams that reduce the chance of pregnancy (congenital uterine malformations and retained intrauterine devices); Current pregnancy (negative pregnancy test documented at the beginning of the cycle) or contraindication for pregnancy; Current pelvic inflammatory disease; Use of fertility modifiers at the beginning of the study such as DHEA, pills, progestogens or estrogens; Use of hormonal medications (except for thyroid); Known history of chemotherapy (except for gestational trophoblastic neoplasia) or radiation therapy; Current or past drug and alcohol abuse within one year of starting the study (drinking more than 14 units of alcohol per week); Current or past smoking within three months of the start of the study (more than 10 cigarettes per day); Hypersensitivity to any of the inputs used in the study; Have already participated in the study; Use of drugs not yet registered within three months of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3xwnr4	Memory training for older adults through computer games	Recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3471	Cognitive stimulation in older adults through a game based on virtual reality: pre and post intervention study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-17	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3xwnr4	<NULL>	Healthy volunteers; both sexes; aged 60 or over; with a Montreal Cognitive Assessement test score greater than 22 points	Individuals diagnosed with disabling and / or neurodegenerative diseases; not literate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7by76r	Effects of &quot; Anti-stress Therapy&quot; on behavior and stress hormones in infertile women and also on weight loss after diet and exercise guidance in those overweight	Data analysis completed	Intervention	2016-04-25	<NULL>	<NULL>	3472	Effects of &quot; Mind Body Therapy&quot; on behavioral and neuroendocrine markers of stress in infertile women and also on reducing the body mass index after diet and exercise guidance in those with overweight and obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Hospital das Clínicas da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7by76r	<NULL>	Infertility; policystic ovarian syndrome; uterus, tube and/or ovarian disfuctions; overweight; obesity.	Refuse to sign the Informed Consent; give up the project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-6wnw9t	GRAU: Group-based therapy for anxiety reduction among university students	Data analysis completed	Intervention	2020-02-11	<NULL>	<NULL>	3473	GRAU: Group-based interventions for the treatment of anxiety among university students with Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-6wnw9t	<NULL>	Inclusion high anxiety. Moderate depression. No risk of suicide.	Exclusion Low level of anxiety.High level of depression. High risk of suicide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7z7f5s	Peanut Ball on Maternal Fatigue in Labor	Not yet recruiting	Intervention	2020-02-11	<NULL>	<NULL>	3474	Effectiveness of Peanut Ball Use on Maternal Fatigue During Labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Associação Vitoriense de Educação, Ciências Cultura	Associação Vitoriense de Educação, Ciências Cultura	https://ensaiosclinicos.gov.br/rg/RBR-7z7f5s	<NULL>	"Age over 18 years
Pregnant woman in the first period of labor
Low risk pregnancy
Gestational age between 37 and 42 weeks
Nulliparous, primiparous and multiparous
Single and cephalic pregnancy"	"Gestation with dead fetus
Parturient without ability to consent
Pregnant women with actual indication for cesarean section
Psychoactive drug use
Use of epidural or oxytocin analgesia before randomization"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-9m57m2	Copaíba Oil in the prevention and treatment of wounds in the oral cavity	Recruitment completed	Intervention	2020-02-11	<NULL>	<NULL>	3475	Copaiba Oil in prevention and treatment of Oral Mucositis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9m57m2	<NULL>	Including individuals of both sexes, aged 18 years or older, diagnosed with solid or hematologic malignancy and under chemotherapy or radiotherapy, the latter in the head and neck region, at the Oncology Center of the Oswaldo Cruz University Hospital, to agree to conduct this study after signing the Informed Consent Form, thus allowing the use, after random draw, of one of the three methods used in this study for prevention and treatment of chemoinduced and radioinduced oral mucositis.	Individuals who do not meet the inclusion criteria; Individuals who meet the inclusion criteria but disagree with the study and / or individuals who initially allow the study and then express their desire to abandon the study will be excluded; Also individuals who abandon the oncological or dental treatment for oral mucositis control during the research period, or who die without being able to complete the analysis of oral condition and mucositis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-5n9c8q	Evaluation of dental extraction made with the less traumatic instrument	Data analysis completed	Intervention	2020-02-11	<NULL>	<NULL>	3476	Evaluation of exodontic technique with minimally traumatic extractor	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-09	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5n9c8q	<NULL>	Presentation of at least one residual root or indication of extraction; teeth severely destroyed by caries or fracture to the point of rendering their restoration unfeasible; prosthetic, periodontal or orthodontic indication; teeth of the jaw or jaw; incisors, canines and premolars; agree to participate in the study by signing the TCLE.	Patients with any factor that contraindicated the surgical act; infection installed on site; uncontrolled systemic disorders; diabetes and hypertension; problems in the coagulation cascade; severe anemia; allergies; patients who used some medicine with interference in bone metabolism; pregnant patients; patients who used drugs that stimulated gingival augmentation; asthmatic patients without the opinion of the pulmonologist; patients who had recently had Chikungunya; patients who were not involved in the planning of surgical and anesthetic techniques; not return to data collection; give up participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3kjd8x	Clinical trial comparing the utilization of Itraconazole and of Pentamidine for the treatment of Cutaneous Leishmaniasis in Amazonas	Not yet recruiting	Intervention	2020-02-11	<NULL>	<NULL>	3477	Itraconazole versus Pentamidine for the treatment of Tegumentary Leishmaniasis caused by Leishmania guyanensis in Amazonas - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-17	Fund. de Medicina Tropical Dr Heitor Vieira Dourado	Universidade do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3kjd8x	<NULL>	Patients with Ulcerated Cutaneous Leishmaniasis, not previously treated; diagnosed through at least one of the following tests: direct examinations of the lesion, biopsy of the lesion, culture or polimerase chain reactions (PCR) positives to Leishmania guyanensis; age of 18-65 years old; both genders; presenting at least 1 to 3 ulcerated lesions, in any localization; lesion diameter between 1-5 cm; clinical evolution not inferior to 1 month and not superior to 3 months.	Evidence of severe underlying disease (heart, kidney, liver, lung) or malignant disease; immunodeficient or HIV-infected patients; severe protein and / or caloric malnutrition; any active and uncontrolled infectious disease, such as tuberculosis, leprosy, systemic fungal disease (histoplasmosis, paracoccidioidomycosis); pregnant or nursing women; history of previous treatment for leishmaniasis; inability or willingness to provide informed consent (patient and / or / legal representative); lack of availability for visits or to comply with study procedures; patients participating in another ongoing clinical study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-88tgky	Effect of changing physical education lessons on  seating time and cognitive function	Recruitment completed	Intervention	2018-08-21	<NULL>	<NULL>	3478	Intervention in physical education classes to reduce sedentary behavior and improve cognitive function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Fundação Universidade de Pernambuco	Escola Superior de Educação Física - Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-88tgky	<NULL>	"Adolescents enrolled in the first year in full-time public high schools;
Adolescents who are students at the Vale do Capibaribe Regional Educational Administration in the state of Pernambuco."	Physical or mental disabilities; Adolescents enrolled in schools that do not implement the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8q7k64	The effect of aerobic exercise on post-stroke motor performance	Recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3479	Aerobic exercise in post-stroke motor performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Universidade Federal do Rio Grande do Norte	Instituto Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8q7k64	<NULL>	Individuals who agree to participate in the study&apos;s free and spontaneous will, thus signing the Informed Consent Form (TCLE) (Appendix 2), should present a clinical diagnosis of stroke, whether ischemic or hemorrhagic, in the chronic phase, considering six months post-stroke; will need to present a medical release that will be granted by your primary physicians to perform aerobic exercises; should present unilateral motor impairment and absence of cognitive deficit, this evaluated through the Mini Mental State Examination (MEEN), obtaining a score between 23 or higher (LYONS et al., 2012).	Individuals who present recent symptoms of hospitalization due to myocardial infarction, chest discomfort, musculoskeletal problems of other conditions other than the sequela of stroke, which limit the ability to exercise, will be excluded from the study; or present other neurological disorders besides stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8yy2bg	Effect of street running on weight loss for people with Overweight and Obesity	Not yet recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3480	Effect of a sports training level running program on the body composition of Overweight and Obesity adults	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8yy2bg	<NULL>	Men and women, aged between 20 and 45 years, with overweight / obese (BMI between 25kg / m² and 34.9kg / m2) (WHO, 2015), previously sedentary for at least three months prior to study enrollment (no physical exercise for at least 10 continuous minutes / week ), have not changed more than 3 kg of body mass in the last 3 months, non-smokers, non-users of supplements and medications that influence body mass, no history of cardiovascular, respiratory, metabolic or musculoskeletal disease affecting the ability to participate in training programs, women are not menopausal or are not in the period of climacteric, moreover, were considered fit in the physical evaluation done immediately before the study.	People who start drug treatment, supplementation or diet and / or start another physical exercise during the intervention period and if they have orthopedic conditions that affect their ability to continue participating in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-65d7cc	Prospective clinical study about gingival inflammation in teeth treated with dental contact lenses without cervical preparation. Evaluation by clinical parameters and inflammatory mediators present in the gingival fluid.	Data analysis completed	Intervention	2020-02-12	<NULL>	<NULL>	3481	Ceramic veneers cemented on no prep teeth. Prospective and longitudinal clinical study of marginal adaptation and evaluation of periodontal behavior using biomarkers of gingival crevicular fluid	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-05	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-65d7cc	<NULL>	Healthy patients who needed ceramic lveneers in the region between teeth 15 to 25; with healthy teeth and in good condition of periodontal health attested by clinical and radiographic examination; with the need to close diastemas; elimination of black spaces; corrections of shape and dental contour with aesthetic and / or functional justification attested by diagnostic waxing.	Periodontal disease active at the time of screening; structural damage to gingival architecture; pregnancy; diabetes mellitus; autoimmune diseases; other uncontrolled systemic changes with a damaging effect on gingival tissues; continuous medication users; presence of hormonal or vitamin deficiency; patients with a history of recent use of anti-inflammatories or antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3hstqm	Genetic determinants of gastrointestinal hemorrhage associated with the use of acetylsalicylic acid as an antiplatelet agent: a case-control study	Recruiting	Observational	2020-02-11	<NULL>	<NULL>	3482	Genetic determinants of gastrointestinal hemorrhage associated with the use of acetylsalicylic acid as an antiplatelet agent: a case-control study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Estadual Paulista (UNESP)	Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-3hstqm	<NULL>	Cases: cases will be considered all patients over 18 years of age who have complicated peptic disease, characterized by upper gastrointestinal bleeding (UGIB) or perforated ulcers, and meet the following criteria: entered the study hospitals with a complaint of UGIB, characterized by the presence hematemesis, dark vomiting or coffee grounds, melena and / or hematochezia and have undergone upper digestive endoscopy (UDE), in which one of the following findings was identified: gastric or duodenal ulcers, erosions, acute lesions of the gastric mucosa or duodenal, gastritis or erosive duodenitis (with or without active or recent bleeding); patients who did not show symptoms of UGIB, but who had undergone UDE for different reasons and during the same signs of recent bleeding (active bleeding, clot adhered, visible vessel) are observed; patients who entered with symptoms of acute perforating abdomen, confirmed by imaging exams (X-ray or computed tomography) and who underwent a surgical procedure, in which it was confirmed to be a peptic ulcer perforation (gastric or duodenal).Control: to prevent control selection from being associated with exposure to acetylsalicylic acid (ASA), controls will be recruited from the preoperative unit among patients who will undergo mild and scheduled surgeries of a non-painful clinical process and not associated with the use of ASA (cataracts, inguinal hernias) / umbilicals or prostate adenomas).	Cases: as primary exclusion criteria for cases, those who: entered the study hospitals complaining of UGIB by other endoscopic diagnoses, such as esophageal varices, gastric neoplasia, hiatal hernia and Mallory-Weiss syndrome will be excluded; patients with in-hospital UGIB; patients with UGIB without diagnosis by upper digestive endoscopy (UDE). Secondary exclusion criteria include: cases whose endoscopy has not been performed within 48 hours after admission to the hospital, or, in the case of outpatients, those whose endoscopy has been scheduled for more than 7 days; patients who were not interviewed until 15 days after admission to the hospital; (iii) critically ill patients and (iv) death. Cases and controls: Under 18 years old; history of neoplasia and coagulopathies; HIV positive patients; narcotics; carriers of a nasogastric or percutaneous tube; patients who went to the hospital for any reason 15 days before the current admission (cases) or the interview (controls); and non-residents of the region for at least three months will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-2sm5nx	Prospective clinical study about the post-operative dental hypersensitivity of teeth restored with ceramic veneers	Data analysis completed	Intervention	2020-02-12	<NULL>	<NULL>	3483	Longitudinal clinical study of teeth restored with metal-free ceramic systems. Prospective study about the post-operative dental hypersensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-10	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-2sm5nx	<NULL>	Individuals who required ceramic restorations in the region of the 2nd right premolar to the left 2nd premolar of the maxillary arch were selected, of both sexes and varied ages, with vital teeth and good condition of periodontal health attested by clinical examination.	Patients who made continuous use of analgesics and / or anti-inflammatory drugs were excluded, as such drugs could mask the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-48b9cz	New regional anesthesia technique can be better than local anesthetic infiltration at surgical site in patients undergoing breast cancer surgical removal	Recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3484	Erector Spinae Block Produces Better Postoperative Analgesia and Prevents Chronic Pain in Patients Undergoing Mastectomy Associated With Axillary Limphadenectomy? Prospective Randomized Study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	AC Camargo Cancer Center	AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-48b9cz	<NULL>	"Patients older than 18 years; female; to be submitted to mastectomy with lymphadenectomy and unilateral breastl reconstruction (prosthesis or expander); described surgeries taking place at AC Camargo Cancer Center; no history of allergy to any medication used in the study; absence of contraindication to the
regional block (coagulopathy and / or local infection); acceptance to participate in the study."	Patients who require a new surgery within 6 months after mastectomy; patients to whom we cannot contact in periods of 3 and 6 months post surgery; patients who require radiotherapy treatment; patients in which occur block failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-62sggb	Educational program to promote physical activity, cognitive and cardiorespiratory performance in sedentary older adults.	Recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3485	Influence of an educational program to promote physical activity, cognitive and cardiorespiratory performance in sedentary older adults.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Estadual de Ciências da Saúde de Alagoas	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-62sggb	<NULL>	Individuals aged 60 years; Sedentaries (&lt;150min of moderate physical activity per week); With subjective complaints of memory impairment or mild cognitive impairment; Agreement to sign the Informed Consent Form to participate in the research.	Illiterate; With health problems that can prevent safe walking; Patients with severe congestive heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-56twgz	Effectiveness of low fat diet for cholesterol control in patients with antiphospholipid syndrome - APS	Recruitment completed	Intervention	2020-02-13	<NULL>	<NULL>	3486	Efficacy of the Hypolipid Diet to control Dyslipidemia in patients with Antiphospholipid Syndrome - APS	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Centro de Hematologia e Hemoterapia de Campinas - Hemocentro	Centro de Hematologia e Hemoterapia de Campinas - Hemocentro	https://ensaiosclinicos.gov.br/rg/RBR-56twgz	<NULL>	"Subjects were selected from patients diagnosed with thrombosis associated with primary APS, followed at the Hemostasis outpatient clinic of the State University of Campinas (UNICAMP). All patients with primary APS and dyslipidemia who had a history of arterial or venous thrombosis of both sexes, aged over 18 years and diagnosed with dyslipidemia were included.
The criteria for the diagnosis of dyslipidemia were: LDL-c above 100mg / dL, HDL-c below 40mg / dL (men) and 50mg / dL (women), TG above 200mg / dL, TC above 190mg / dL , non-HDL cholesterol above 130mg / dL or still on low-fat medications. LDL-c values above 100mg / dL were considered because they were patients with a history of thrombotic disease."	Patients diagnosed with systemic autoimmune disease or neoplasia were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-6cm6q8	Impact of preoperative education on the anxiety of patients undergoing gallbladder surgery: a randomized controlled trial	Recruiting	Intervention	2020-02-13	<NULL>	<NULL>	3487	Impact assessment of preoperative audiovisual education during pre-anesthetic evaluation on Anxiety of patients undergoing cholecystectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-08	Universidade Federal do Amazonas	Hospital Universitário Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-6cm6q8	<NULL>	Patients of both sexes;patient over 30 years old and under 70 years old;patients diagnosed with cholelithiasis	Patients with special needs: visual, auditory or cognitive; indigenous patients; patients with a history of psychiatric illness; patients on psychoactive drug treatment; patients who will perform another procedure in conjunction with cholecystectomy; incomplete or incorrect questionnaires; non-acceptance of the terms of the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7s93fj	Relationship between general movements, trunk control, hand reach and fine motor function of premature babies	Not yet recruiting	Observational	2020-02-13	<NULL>	<NULL>	3488	Prediction between generalized movements and level of truk control, manual reach and fine motricity of pre-term infants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-03	Kaitiana Martins da Silva	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s93fj	<NULL>	The inclusion criteria for the EG (Experimental Group) will be: infants with corrected age between 1 to 5 months on the date of the evaluation, gestational age less than 37 weeks, in addition to signing the Informed Consent Form (ICF) by the parents or responsible. For the CG (Control Group), they will be born at term (gestational age at birth from 37 to 41 weeks and 6 days) and paired with the same age. For both groups, both genders will be considered, birth weight appropriate for gestational age and Apgar score between 7 and 10 in the first and fifth minutes	Infants who have congenital malformations, genetic syndromes, congenital changes, postural deformities or other changes that may impair the neuropsychomotor and socio-cognitive development will not participate in the study. In addition to those that parents / guardians do not sign the ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-23xz8s	Sports mouthguards: Presence of microorganisms and efficiency in the use of a disinfectant agent for their removal.	Recruitment completed	Intervention	2020-02-13	<NULL>	<NULL>	3489	Sports mouthguards: evaluation of microbial contamination and effectiveness of chlorhexidine spray as a method of disinfection	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia de Ribeirão Preto	Yuri Jivago Silva Ribeiro	https://ensaiosclinicos.gov.br/rg/RBR-23xz8s	<NULL>	Both genders; minimum age of 09 years and maximum of 13 years; absence of periodontal disease; absence of caries lesions with cavitation; general good health; were not using antibiotics and / or antimicrobial solutions for a minimum period of 3 months	Users of fixed and removable orthodontic appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5n2x5v	The value of Gadoxetic Acid as a hepatobiliary-specific contrast agent in Magnetic Resonance Imaging in the assessment of focal liver lesions	Data analysis completed	Intervention	2020-02-13	<NULL>	<NULL>	3490	The value of Gadoxetic Acid as a hepatobiliary-specific contrast agent in Magnetic Resonance Imaging in the assessment of focal liver lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-03	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5n2x5v	<NULL>	Magnetic resonance imaging of the abdomen using gadoxetic acid as a contrast agent in the assessment of focal liver lesions that had already been identified in previous examinations (ultrasound, computed tomography or magnetic resonance with conventional gadolinium), but which still remained undetermined, requiring complementation diagnostics, performed at the HC of FCM / UNICAMP, from January 2015 to December 2018	Absence of definitive diagnostic criteria for focal liver lesions; radioablation and / or chemoembolization prior to the lesion to be analyzed; examination artifacts preventing adequate characterization of the lesion to be analyzed; absence of detection of the focal lesion in the MR examination; age under 18 and over 78	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-4qqbps	"Use of auriculotherapy in the treatment of problems arising from Chikungunya:
An approach to primary care"	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3491	Auriculotherapy in patients with sequelae of Chikungunya Fever: An approach in primary care	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Escola Multicampi de Ciências Médicas	Escola Multicampi de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-4qqbps	<NULL>	Seniors aged 60 and over; both sexes; proper locomotion; report pain; registered in health institutions.	Cognitive deficit; disabling neurological deficits; refuse to respond to the assessment tools; non-attendance at scheduled appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-6ts54x	Effect of propolis on joint pain	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3492	Analysis of the therapeutic effect of propolis in patients with joint pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Pós Graduação em Ciências da Saúde	Pós Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-6ts54x	<NULL>	Patients with clinical diagnosis of joint pain due to inflammation in the intra and / or peri-articular structures by a doctor and presence of pain caused by the disease mentioned during the initial evaluation, of both sexes and any ethnic group will be included in the study.	Exclusion criteria are: pregnant patients with a history of bee sting allergy and other therapies; hx of gastrointestinal bleeding, gastric perforation; kidney disease, liver disease; current history of alcoholism; use of anticoagulants; prosthetic implants or pacemaker; serious uncontrolled chronic diseases (high blood pressure, diabetes mellitus, heart disease and other diseases that, by their nature or by the proposed treatment, may interfere with the proposed assessment). Individuals who make use of various pharmacological therapies will be evaluated professional pharmaceutical pain able to understand possible pharmacological interactions, deciding for the insertion or exclusion of this individual in the current research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-9vjfmz	Photobiomodulation associated with short-term Eccentric Exercise Protocol on pain intensity and function in patients with Lower Limb Tendinopathy	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	3493	Single or Cluster Photobiomodulation, associated with the Eccentric Exercise Protocol  in patients with patellar and Achilles tendinopathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Departamento de Ciências do Movimento Humano da universidade federal de São Paulo	Departamento de Ciências do Movimento Humano da universidade federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9vjfmz	<NULL>	Participants aged between eighteen and fifty years with medical diagnosis of patellar tendon or tendon tendon disease for at least 3 months and have a VISA score (P and A) of less than 80 points without treatment for at least 3 months and signed the term of free and informed consent.	"Individuals with neurological disorders that affect cognitive behavior and pain perception; conditions in the knee or ankle region (such as rheumatoid arthritis; osteoarthritis or fractures) that make it impossible to perform the assessments or protocol proposed; 
pregnancy; previous surgical procedure in the tendon; use of non-steroidal anti-inflammatory drugs (NSAIDs) during the last 2 weeks; injection of corticosteroids; diabetes mellitus and uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-2xdpsr	Body Composition and Renal Function in Kidney Transplant Recipients: comparison between combined training and usual care.	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3494	Quality of life, functional capacity, body composition and heart rate variability in Kidney Transplant recipients undergoing Physical Exercise Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2xdpsr	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7q63c4	Association between Low Level Laser Therapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3495	Association between phototherapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7q63c4	<NULL>	women aged 55 to 75 years; with knee osteoarthritis grades II or III on the Kellgren and Lawrence scale confirmed by radiological examination; with cognitive ability to understand the study according to the cut-off score of the Mini Mental State Examination; and classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version (IPAQ).	Presence of cardiovascular desease; presence of neurological desease; presence of musculoskeletal disease that makes it impossible to perform the exercise protocol; use of conventional treatment; use of unconventional treatment; use of alternative treatments that may interfere with the results of the study (physical therapy treatment and / or injections of intra-articular corticosteroids or hyaluronic acid during the last 3 months); absolute contraindication for photobiomodulation, such as the presence of neoplasia in the lower limbs region; and individuals who have malnutrition (BMI less than 18.5) or morbid obesity (BMI equal or more than 40).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-77mwqf	Comparison of the effects of Myofascial Release Technique on the pressure pain threshold and range of motion in individuals with restricted neck movement	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3496	Comparison of the effects of Passive and Active Myofascial Release Technique on the pressure pain threshold  and range of motion in individuals with cervical mobility restriction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-13	Vítor Dias Ferreira	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-77mwqf	<NULL>	Individuals of both sexes; between 18 and 50 years old; with no complaints of cervical pain in the last two weeks and with a cervical range of motion difference of at least 10 ° between right and left sides for rotational movement.	History of trauma; injuries or surgery in the cervical region; contraindications to receiving manual therapy such as infections and active inflammations; neoplasms; deep vein thrombosis; skin changes; congenital anomalies; presence of symptoms such as hypotension; fever; nausea; lethargy; flushing and edema in the region of application of the technique; use of analgesic medication in the last 48h and have received myofascial release technique in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-9yyd5v	Effects of Physical Training with Exergames in Sedentary and / or Overweight adolescents	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3497	Effects of Virtual Reality Training on Sedentary and / or Overweight teenagers	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-10-12	Maria Luísa Melo Barbosa	Mércia Lamenha Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-9yyd5v	<NULL>	Sedentary and / or overweight adolescents. Have independent walking. Present preserved cognitive ability.	Hearing loss. Visual deficit. Neuromuscular diseases. Have undergone surgery on lower limbs less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-2myky3	A study of the efficacy of knee alcohol block for the treatment of knee arthrosis pain	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3498	A prospective study of the efficacy of anterior and posterior knee alcohol neurolysis for the treatment of knee osteoarthrosis pain	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2myky3	<NULL>	Aged over 18 years. With knee pain for more than six months without improvement with clinical treatment and clinical and imaging diagnosis (radiography) of knee osteoarthritis with moderate pain intensity (pain greater than 4 by numerical scale).	Patients with cognitive impairment or psychiatric illness or other causes of knee pain (trauma; complex regional pain syndrome; prosthesis); infection at the puncture site; coagulopathy; anticoagulant use will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7djt4p	Searching susceptibility to hepatitis A among men who have sex with men in Rio de Janeiro	Not yet recruiting	Intervention	2018-10-05	<NULL>	<NULL>	3499	A cross-sectional study to determine susceptibility to hepatitis A among men who have sex with men in Rio de Janeiro (HEPAGAY)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-27	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-7djt4p	<NULL>	Men aged 18 to 35 years old male at birth who report having had sexual relations with people of the same biological sex in the last six months and live in Rio de Janeiro metropolitan area.	Subjects who have received at least one shot of hepatitis A vaccine at some point in their life. Subjects who live with any autoimmune disease. Any other condition which based on the opinion of the investigator  may compromises adherence to the protocol or otherwise interferes with the objectives of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-969mcq	Effects of Nutritional Supplementation on older seniors	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3500	Effects of protein supplementation on body composition and functionality of oldest old residents in a Long-Term Care Facility	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-26	Pontifícia Universidade Católica do Rio Grande do Sul	Apsen Farmacêutica S. A.	https://ensaiosclinicos.gov.br/rg/RBR-969mcq	<NULL>	ILPI residents; both sexes; elderly aged 80 and over.	Undergoing surgery on the gastrointestinal tract previously.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-8mxb7w	Impact of obesity on blood vessel response to stress mediated by the hormone angiotensin II	Recruitment completed	Intervention	2020-02-17	<NULL>	<NULL>	3501	Impact of Obesity on endothelial response to Mental Stress mediated Angiotensin II	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-8mxb7w	<NULL>	Age between 20 and 50 years; both sexes; body mass index between 25 kg.m-2 and 35 kg.min-2; absence of any chronic diseases (hypertension, diabetes, chronic kidney disease, heart failure, among others, except obesity) and musculoskeletal abnormalities; do not practice physical activity regularly (exercise lasting less than 30 minutes three times a week); and do not make regular use of medications such as vitamins or anti-inflammatory drugs.	Menopausal or postmenopausal women; smokers; athletes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-54y5wr	Efficacy of using vaginal radiofrequency, vaginal estrogen, or vaginal moisturizer for the treatment of post menopausal vaginal dryness: randomized clinical trial	Recruiting	Intervention	2020-02-18	<NULL>	<NULL>	3502	Efficacy of vaginal monoplar focused radiofrequency, vaginal estrogenic therapy, or vaginal polyacrylic acid, for the treatment of genito urinary syndrome fo menopause (GSM): randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-02	Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Unicamp	Faculdade de Ciências Médicas da Universidade Estadual de Campinas, Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-54y5wr	<NULL>	Menopausal women; sexually active; between 30 and 75 years; with at least one of the symptoms of SGM classified as moderate and / or severe.	"The explicit refusal or inability of the woman to participate in the study, and any reasons that prevent the application of the treatment;
BMI 35 kg / m2; Chronic renal failure; Hepatic insufficiency; Tuberculosis; Ascites and anasarca; Febrile conditions of unknown origin; History of estrogen-dependent neoplasias; Active sexually transmitted disease; Cardiovascular diseases such as thrombophlebitis, thrombosis and peripheral arterial disease); Active vaginal infection (bacterial vaginosis or candidiasis); Oncotic cytology altered in the last twelve months, such as atypical squamous cells of significance indeterminate (ASCUS), atypical squamous cells of undetermined significance can not be excluded high-grade intraepithelial lesion (ASC-H), low-grade squamous intraepithelial lesion (LSIL), and lesion
high-grade squamous intraepithelial (HSIL); Vaginal bleeding of unknown cause; active collagen diseases; Pelvic radiation therapy; Metal implants (pacemaker or automatic defibrillator / cardioverter, copper IUD); Not have used in the last month medications known to be impacting collagen metabolism and in the healing process, such as steroidal and nonsteroidal anti-inflammatory drugs; Do not use NSAIDs and AIES in the last month (they affect collagen metabolism and healing); Use of vaginal moisturizers in the last 6 months; Use of local estrogen therapy in the last 6 months; Use of systemic hormonal therapy in the last 6 months; Absolute contraindications to hormonal therapy, according to the Brazilian Consensus on Hormonal Therapy, 2018."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-283byt	At-home bleaching with WhiteClass 10%, applied on the palatal face, is effective	Data analysis completed	Intervention	2020-02-19	<NULL>	<NULL>	3503	Effectiveness of at-home bleaching with 10% Hydrogen Peroxide applied on the palatal face. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-283byt	<NULL>	Volunteers between 18 and 40 years old; no systemic diseases; without caries; no periodontal diseases; having at least two central incisors or canines with a color C2 or darker; with the six upper anterior teeth free of restorations on the palatal and buccal surfaces; sound enamel; without pathological, physiological and drug alterations	Volunteers with orthodontic braces; severe crowding; presence of intrinsic spots; taking anti-inflammatory drugs; smoker; alcoholist; pregnant women; lactating women; patients who report severe sensitivity during treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-639bff	Comparison of the effectiveness of sweetened solution and foot massage in relieving pain in infants admitted to a neonatal intensive care unit	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3504	"Comparison of eficacy of glucose and
reflexotherapy in newborn pain relief in Neonatal Intensive
Therapy Unit: A clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-27	Daniele Vieira Dantas	Daniele Vieira Dantas	https://ensaiosclinicos.gov.br/rg/RBR-639bff	<NULL>	The inclusion criteria of the research are Newborns equal to or greater than 32 weeks of gestation or weighing 1500g or more undergoing exam collection 12-hour laboratory tests / blood gas analysis / blood culture through arterial puncture.	Neonates diagnosed with perinatal asphyxia (Apgar score less than 5 in 5 minutes); which do not show reflex who are using analgesics or sedatives; with malformations congenital disorders, syndromes and neurological manifestations; the son of women drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5b6b6s	Evaluation of Different Types of Patients with Pulmonary Emphysema	Recruiting	Observational	2017-07-04	<NULL>	<NULL>	3505	Evaluation of Different Clusters in Patients with Chronic Obstructive Pulmonary Disease - COPD	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Faculdade Medicina de Botucatu	AstraZeneca do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5b6b6s	<NULL>	Patients with all COPD severity will be included according to the GOLD classification in 2014. Clinically stable patients, characterized by the absence of exacerbation and regular use of medications for treatment in the last three months	Patients who have used systemic corticosteroids in the last three months, who have other respiratory diseases; as asthma, bronchiectasis and active tuberculosis and cancer, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-3tzrxf	Electrical stimulation and menstrual cramps: Is there a correlation between treatment time and pain relief?	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3506	Transcutaneous electrical nerve stimulation and primary dysmenorrhea syndrome: Is there a correlation between intervention time and pain relief?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Centro Universitário de Barra Mansa	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-3tzrxf	<NULL>	Aged 18 to 35 years; pelvic pain caused by primary dysmenorrhea for more than 6 menstrual cycles; pelvic or transvaginal ultrasound image of at least 6 months without changes; deprivation of sexual intercourse one day before treatment; regular menstrual cycle between 21 and 35 days; be between the first and third day of the cycle; grades between 3 and 10 on the Visual Analog Pain Scale (VAS)	Age under 18 and over 35 years, use of analgesics and other therapies for pelvic pain or any systemic disease, alcohol consumption during menstrual cycle, gynecological disorders, undiagnosed abdominal pain, history of lower abdominal and pelvic surgery Pacemakers, Heart Pacemaker, Heart and Skin Diseases, Cancer, Pregnant, Mental Disorders, Breastfeeding, Grade EVA Less than 3, Painful When Clinic Is Not Open (Saturday, Sunday, 10 PM) and 7:00)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-2zdvfp	Effect of the Radiofrequency and Pelvic Muscle Training in the Treatment of Women with Vaginal Laxity.	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3507	Effect of Fractionated Microablative Radiofrequency and Pelvic Floor Muscle Training in the Treatment of Women with Vaginal Laxity: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Faculdade de Ciência Médicas da Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-2zdvfp	<NULL>	Will be included women 18 years of age onwards and complaining of vaginal laxity assessed by the direct question and Vaginal Laxity Questionnaire, and willingness to participate in therapies at the dates and places scheduled for the proposed treatment.	Patients with decompensated cardiac and metabolic diseases, as well as pacemaker use; cognitive impairment; peripheral or central neurological disorders; presence of any cancer; presence of cervical dysplasia; history of active urinary or vaginal infection; presence of pelvic organ prolapse stage 2 onwards; patients undergoing physical therapy treatment with pelvic floor training; use of estrogen vaginally in the last 6 months; degree of force of contraction of the pelvic floor muscles equal to zero according to the Modified Oxford Scale and patients who have already undergone prolapse or sling correction surgery will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-72cyh7	Analysis of the effectiveness of different root canal treatments in the reduction of bacteria and their products	Data analysis completed	Intervention	2019-02-25	<NULL>	<NULL>	3508	Analysis of the effectiveness of endodontic procedures in the reduction of microorganisms and their by-products	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2016-10-15	Faculdade de Odontologia de Araçatuba - Unesp	Fundação de Amparo à Pesquisa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72cyh7	<NULL>	A total of 24 patients who presented with primary endodontic infection were included in this study. The teeth selected should have a primary endodontic infection, with absence of spontaneous painful symptomatology, absence of periodontal pocket with a depth greater than 4 mm, and that could be isolated with a rubber dam.	Those who received antibiotic, anti-inflammatory or analgesic treatment in the last three months or who had any uncontrolled generalized disease were excluded from work.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5435x9	Brain electrical stimulation associated with speech therapy in speech apraxia in young people with Trisomy 21 (Down Syndrome)	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3509	Transcranial Direct Current Stimulation associated (tDCS) with Prompts for Restructuring Oral Muscle Phonetic Targets (PROMPT) in Apraxia of Speech in young people with Trisomy 21	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal do Espírito Santo	Ester Miyuki Nakamura Palacios	https://ensaiosclinicos.gov.br/rg/RBR-5435x9	<NULL>	They have to present clinical and / or genetic diagnosis of Trisomy 21 and meet criteria for intellectual disability (DSM-5) or intellectual development disorder (equivalent name found in ICD 11), and are classified according to the severity as mild (F70), moderate (F71), severe (F72), and profound (F73) according to ICD 10; they have to meet criteria for communication disorders (DSM-5), specifically speech sound disorder (F80.0); they should be clinically fit for the treatment proposed in the study and should therefore not present past or current illnesses that may be aggravated during treatment; they should also not have abnormalities in the laboratory tests, which may suggest a deterioration of their physical condition during the participation in the study; they should be able to understand the Portuguese language.	"It should not be included young people diagnosed with other associated mental disorders such as attention deficit hyperactivity disorder (ADHD), depressive and bipolar disorders, anxiety disorders, autistic spectrum disorder, stereotypic movement (with or without self-injurious behavior), impulsive disorders, and major neurocognitive disorders;
those who have any metal in their brain or skull (splinters, fragments, pins, etc.) except for titanium, history of epilepsy, severe head injury, cochlear implant, cardiac pacemaker or intracardiac metal lines, should also not be included because of restrictions on the noninvasive brain stimulation technique; they will not be included due to MRI restrictions if they are carrying metal implant such as: heart valve, plate, pin, screw, stent, brain aneurysm clip, body shrapnel, piercing, metal prosthesis, orthodontic appliance, electronic implants such as cardiac pacemakers, neurostimulators, cochlear implants, claustrophobic patients and those with permanent makeup or tattooing done in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-38jcm9	Pharmacological assay model on the influence of the CYP2C9 gene mutation in anti-inflammatory drugs from saliva samples and their role in the prescription individualization	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3510	Pharmacokinetic/pharmacodynamic (PK/PD) model on the influence of P450 (CYP2C9) genetic polymorphism of non-steroidal anti-inflammatory drugs and major metabolites from saliva samples by LC MS/MS and their role in prescribing personalization	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-38jcm9	<NULL>	Good general health condition; absence of infection and inflammation; absence of systemic diseases; do not use any medicine that may alter the perception of pain or antidepressant, diuretic or anticoagulant medicines.	Patients with systemic diseases; patients with inflammation or infection; patients with a history of gastrointestinal bleeding or ulcerations; patients with cardiovascular, renal or liver disease; patients taking antidepressant, diuretic or anticoagulant medications; patients with a history of allergy to any other NSAIDs; pregnant and lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-78mt53	Efficacy of fractional Radiofrequency Microablation in the treatment of vaginal dryness, burning and itching of women with Breast Cancer: a randomized trial	Recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3511	Efficacy of Fractionated Radiofrequency Micro Ablation in the treatment of Genito-Urinary Syndrome in women with Breast Cancer: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-78mt53	<NULL>	Antecedente pessoal de câncer de mama;apresentar ressecamento vaginal associada ou não a dispareunia, ardência ou prurido vaginal;menopausa fisiológica com tempo de amenorreia superior a doze meses.	Current chemotherapy treatment for breast cancer; pacemaker use; presence of genital prolapses; decompensated heart disease; cognitive impairment; peripheral or central neurological disorders; presence of any other cancer; presence of cervical dysplasia; urinary or vaginal infection active; decompensated metabolic diseases; patients currently in use or within the last six months of some vaginal therapy; positive serology for HIV, hepatitis bece genital condylomatosis; previous pelvic radiotherapy; previous surgery on the vagina.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-54g48y	Comparison between intravenous Methadone and Morphine on the quality of anesthesia recovery after stomach reduction surgery	Data analysis completed	Intervention	2019-02-01	<NULL>	<NULL>	3512	Effect of intravenous Methadone compared to Morphine on the quality of anesthesia recovery after laparoscopic gastroplasty surgery: prospective, randomized and controlled clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-01-21	Financiamento próprio.	Financiamento próprio.	https://ensaiosclinicos.gov.br/rg/RBR-54g48y	<NULL>	Patients included in the study protocol should meet the following criteria: age between 18 and 65 years; body mass index (BMI) &gt; 40 kg / m2 regardless of the presence of comorbidities or BMI between 35 and 40 kg / m2 in the presence of comorbidities; framed in the ASA (American Society of Anaesthesiologists) from I to III; submitted to videolaparoscopic gastroplasty surgery under general anestesia; expected hospital stay of up to 36 hours.	It will be excluded from the study protocol the patients who: refuse to participate of the proposed study; have history of adverse reactions to any drug included in the study protocol; have history of alcohol or illicit substances abuse; are chronic users of opioids for various reasons; have hepatic or renal failure; need for conversion from laparoscopic surgery to laparotomy; concomitant surgical approach on other surgical site; have the presence of coexisting diseases that impair cognitive ability; have the presence of poorly controlled psychiatric illnesses; and have retarded neuropsychomotor development.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9gj9mn	The effect of combining high-intensity interval training with nitrate supplementation in trained people	Not yet recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3513	Acute and chronic effects of High Intensity Interval Training associated with Sodium Nitrate Supplementation on Aerobic Parameters and Performance of Physically Active Subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9gj9mn	<NULL>	Male individuals, aged between 18 and 35 years old, without distinction of education levels or other sociodemographic characteristics will be selected; with absence of cardiovascular, metabolic, respiratory, orthopedic diseases and neurological, muscular, cognitive deficit that make it impossible to understand the evaluation or verbal commands.	Individuals who present intolerance or allergy after supplementation will be excluded; Failure to follow directions given in advance of each experimental session; refuses to take supplementation; have difficulty adapting to the protocol; have more than six absences during the intervention period (corresponding to 25% of the total number of sessions in the 8 weeks of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-4hzsyv	Manual Therapy and Photobiomodulation in the Treatment of Cervical Pain	Recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3514	Physical Therapy in the Treatment of Myofascial Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-19	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4hzsyv	<NULL>	"Be between 18 and 40 years old;
Presence of active trigger point in upper trapezius;
Present pain in the cervical region beginning in up to three months;
Present pain level greater than 3 on the Visual Analog Scale in the last 30 days for the cervical region."	"Have a BMI greater than 30;
Have whiplash injury and / or cervical pathologies such as herniated disc and thoracic outlet syndrome;
Be undergoing treatment for pain in the neck and shoulders;
Make use of analgesic, anti-inflammatory and / or muscle relaxant medications and anticoagulant medications."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-77vpp6	Outcomes in Mothers with Delayed Umbilical Cord Clamping	Recruitment completed	Intervention	2020-02-20	<NULL>	<NULL>	3515	Maternal Outcomes of Delayed Umbilical Cord Clamping	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-77vpp6	<NULL>	Women with low-risk prenatal care, hospitalized for parturition in the maternity of the HCPA during the study period with the ability to understand and sign the ICF.	Maternal: Gestational age below 37 weeks, HIV infection, Rh isoimmunization, severe maternal anemia (hemoglobin &lt; 9g/dL), pregnancy diabetes, placenta previa, placenta detachment, HELLP syndrome, maternal coagulopathy. Newborns who presented some of the following conditions: tight cervical cord circular, hypotonic Newborns, meconial amniotic fluid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-67ynvt	The Effect and safety of Botox in the treatment of patients with Spinal injury associated with Human T-cell Lymphotrofic Virus type I	Recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3516	Efficacy and safety of Botulinum Toxin in the treatment of spasticity in patients with Tropical spastic paraparesis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-14	Hospital Universitário Professor Edgard Santos	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-67ynvt	<NULL>	Individuals over 18 years old; both sexes; diagnosed with tropical spastic paraparesis, confirmed with Elisa and Western Blot tests; who have not used botulinum toxin to treat spasticity	individuals who are pregnant; bleeding disorders; with an infectious skin lesion at the injection site; other neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-56f4w8	Effect of Led Therapy (630 ± 20nm) in Herpes Simplex Labial	Recruitment completed	Intervention	2020-02-20	<NULL>	<NULL>	3517	Effect of Led Therapy (630 ± 20nm) in Herpes Simplex Labial- Randomized Double-Blind Controlled Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Universidade do Vale do Paraiba UNIVAP	Universidade do Vale do Paraiba UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-56f4w8	<NULL>	age between 18 and 59 years old, Caucasian, first manifestation of the disease, history of cold sores and / or presented the lesion, healthy individual without comorbidities, agree and sign the Informed Consent Form, after clarifying the research.	presence of neoplastic lesions in the oral environment; HSV-2 lesion in the genitalia; belonging to the Fitzpatrick V and VI classification scale; pregnant or lactating women; hypersensitivity to any component in the acyclovir formula; liver or kidney problems against acyclovir indication ; intraoral herpes; For ethical reasons excluded volunteers received conventional treatment guidance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-6yt2hp	Effects of Platelet in the treatment of wounds in patients with Diabetes	Recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3518	Effects of Platelet-Rich Plasma in the treatment of complex wounds in patients with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-6yt2hp	<NULL>	Type I Diabetes Mellitus Type II; Chronic wound carrier (over 12 weeks) Both sexes; Age between 30 to 70 years; Controlled blood glucose; Normal peripheral platelet count.	Use of oral anticoagulants, Wound with osteomyelitis and / or with exposure of tendons or bones; Wound with local gangrene or close to the anatomical site. Patients with bleeding tendencies; Uncontrolled DM (HBA1C greater than 7.5); Serum albumin less than 2.5 g / dL; Hemoglobin less than 10.5 mg / dL; Malignant neoplasms; Lupus erythematosus; Pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-523n7r	Effect of simvastatin 20mg in bone formation after Removal of lower third molar teeth	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3519	Efficacy of simvastatin 20mg on bone regeneration after lower third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-08	Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-523n7r	<NULL>	The inclusion criteria were as follows: adult patients aged between 18-40 years old, of both genres, of any ethnicity, healthy, without allergy to the drugs used in the research or its components and who are not using any other medication. All patients must have both lower third molars, included, with the same inclusion pattern according to the Pell &amp; Gregory classification, healthy, with indication of extraction and without signs of pericoronitis or inflammation.	The exclusion criteria were: patients with an inability to open their mouth for surgery; exceed 40 minutes in any surgery; fracture or postoperative infection; recent history of chemotherapy and / or radiation to the head and neck; giving up participating in the research at some point; make use of medications that have a known interaction with any drugs used in the study; smokers, pregnant or lactating women; did not perform the tests requested in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-6jkk47	Influence of sleep training at different times of the season for basketball players in wheelchairs and conventional basketball.	Recruiting	Observational	2020-02-20	<NULL>	<NULL>	3520	Influence of the sleep-wake cycle in different moments of periodization in the performance of disabled and conventional athletes of basketball	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-02-02	Unversidade Estadual de Campinas	Unversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6jkk47	<NULL>	Wheelchair and conventional basketball athletes registered in official competitions; age from 15-60 years old	injured athletes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-6gy3ss	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3521	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6gy3ss	<NULL>	The study population consisted of women with a Body Mass Index (BMI) above 18.5 kg / m2 and less than 25.5 kg / m2 and aged between 18 and 35 years.	Women diagnosed with autoimmune diseases or using immunosuppressive drugs were excluded from the research; with clinical diagnosis of diabetes, thyroid dysfunction, chronic kidney disease or liver disease; who underwent bariatric surgery prior to the research; chronic drinkers; using drugs that alter appetite or body weight (appetite suppressants) in the last twelve months; had attended food restriction programs or were using nutritional supplements in the last twelve months; manifested feverish state in the weeks of the research; failure to follow the protocol stipulated for data collection or refused to carry out any of the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9b6486	Vomiting and tremor control after gallbladder surgery	Recruitment completed	Intervention	2020-02-20	<NULL>	<NULL>	3522	Effect of the 5-HT3 antagonist on antiemetic control and post-anesthetic tremor in videocolecystectomy with total intravenous anesthesia with propofol-remifentanil	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal de Uberlandia	Universidade Federal de Uberlandia	https://ensaiosclinicos.gov.br/rg/RBR-9b6486	<NULL>	Age between 18 and 70 years; physical status ASA 1 or 2; elective surgery; upper abdominal laparoscopy; general intravenous anesthesia; analysis of the QTc interval on the electrocardiogram	History of hypersensitivity or contraindication to the use of the 5-HT3 antagonist. Intellectual inability to cooperate with evaluation procedures. Pregnant patient. Use of any potentially antiemetic medication within less than 24 hours. Symptom of nausea or vomiting in the last 24 hours. Alcoholics. Drug users.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9qxx9j	Effect of probiotic use on obesity-associated diseases	Recruiting	Intervention	2020-02-17	<NULL>	<NULL>	3523	Effects of probiotic supplementation on obesity-associated metabolic and immunological changes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-19	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-9qxx9j	<NULL>	Both genders; aged 20 years and over; accept the terms of the informed consent form IC; Waist circumference&gt; 102 cm for men and&gt; 88 cm for women; Blood pressure&gt; 130 mmHg or&gt; 85 mmHg; history of hypertension; Triglycerides&gt; 150 mg / dL; patients on drug treatment for elevated triglycerides; HDL-cholesterol &lt;40mg / dL for men and &lt;50mg / dL for women or on drug treatment for low HDL levels; Blood glucose&gt; 100mgdL or in drug treatment for hyperglycemia. AST greater than 31 U / L (women) and 37 U / L (men) and / or ALT greater than 31 U / L (women) and 41 U / L (men).	Body Mass Index (BMI) greater than or equal to 40; Use of commercial probiotics consumed in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3gpg5w	Workout with Arterial Flow Restriction in Patients with Kidney Disease in Different Stages	Recruiting	Observational	2020-02-21	<NULL>	<NULL>	3524	Strength Training with Blood Flow Restriction in Chronic Kidney Disease Patients in a Conservative and Hemodialytic Stage	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3gpg5w	<NULL>	Be on hemodialysis for at least six months for hemodialysis groups. Have a glomerular filtration rate of less than 90ml / min / 1.73m2. Have been diagnosed with hypertension according to the VI Brazilian guidelines for hypertension (2010). Be able to practice physical exercises.	Present pain during the exercise protocol. Develop cancer throughout the intervention. Present thrombosis during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3rckr6	Effect of music in reducing women&apos;s stress at the time of the uterine cancer screening	Recruitment completed	Intervention	2020-02-24	<NULL>	<NULL>	3525	Potential of musical auditory stimulus in stress reduction in women submitted to cervical cytopathological examination	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-12	Universidade Regional do Cariri-URCA	Universidade Regional do Cariri-URCA	https://ensaiosclinicos.gov.br/rg/RBR-3rckr6	<NULL>	"Volunteers aged 25 to 40 years; body mass index between 18.5 and 30 kg / m²; undergoing follow-up Pap smear, ie
be undergoing the second or third collection, discarding the first time"	volunteer smokers; who are diagnosed with cardiorespiratory, neurological or hormonal disorders due to climacteric; taking medications that influence cardiac autonomic regulation; pregnant women; with hearing disorders and women who consumed alcohol in the 12 hours prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-73s4x3	Efficacy of a physical therapy protocol of simultaneous tasks in the functions of elderly people who practice physical activity	Data analysis completed	Intervention	2020-02-26	<NULL>	<NULL>	3526	Effectiveness of a dual task physiotherapeutic protocol on the functionality of active elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal do Triângulo Mineiro	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-73s4x3	<NULL>	Volunteers aged 60 or over; with self-reported ability to walk at normal speed for 150 meters or more, without sitting or using support; physically active according to the International Physical Activity Questionnaire.	Sedentary volunteers; with severe cognitive impairment suggestive of dementia according to the Mini Mental State Examination; with significant or chronic orthopedic pain and joint deformities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-4xqpmm	Effects of exercise for chronic kidney patients during hemodialysis.	Recruitment completed	Intervention	2020-02-26	<NULL>	<NULL>	3527	Effects of a combined intradiiality exercise program in patients with chronic renal disease: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4xqpmm	<NULL>	Inclusion: age over 18 years; due to the ease of travel and use of the consent form; being more than three months on hemodialysis, due to treatment adaptations; does not present any type of motor impairment that makes it impossible to evaluate and perform the exercise protocol, for patient and researcher safety. The conditions will be submitted to the medical staff of the renal replacement therapy unit; do not use medical contraindications for physical exercise; cognitive ability to understand the research process and sign the consent form; willingness to participate in the study.	Exclusion: Known unstable medical condition (angina, uncontrolled hypertension, congestive heart failure, arrhythmogenic heart disease); Neuromuscular disorders (myasthenia gravis, amyotrophic lateral sclerosis, congenital muscular dystrophies, cerebellar ataxias); Pacemaker carriers; Stop voluntarily participating in the study; Do not perform exercise sessions for two consecutive weeks; Discharge or abandon treatment; Not being collaborative in the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-8xcjmf	Prenatal group&apos;experiences	Not yet recruiting	Intervention	2020-02-26	<NULL>	<NULL>	3528	Prenatal group implementation at the center for integral health care of women at the state university of Campinas: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-11	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8xcjmf	<NULL>	"Pregnant women 18 years of age and over;
Pregnant women with gestational age (GA) less than 20 weeks of gestation;
Pregnant women in prenatal care at PNE on Wednesday of CAISM / UNICAMP;
Signing of the Informed Consent (IC)"	"Professional indication validated by PNE teacher to individualize care (will be sent to the indicated professionals or sectors, eg hospitalization, other outpatient clinic, etc.);
ICF Withdrawal"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-35szwc	Role of cardiovascular biomarkers in the Periodontal Disease associated to Diabetes	Recruiting	Intervention	2020-02-26	<NULL>	<NULL>	3529	Role of monocyte subtypes, circulating microparticles and chemokines in the Periodontal Disease associated to Diabetes	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-22	Universidade Santo Amaro	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35szwc	<NULL>	The study will include patients of both sexes; who follow up at the University of Santo Amaro Dental Clinic - UNISA; aged between 40 and 75 years; with periodontal disease (moderate and advanced); periodontal disease associated or not with diabetes.	Exclusion criteria include toothlessness; periodontal treatment within the last six months; HIV-positive; positive-hepatitis C virus (HCV) or positive-hepatitis B (HBV); and / or other systemic disease; smoking; gingivitis or mild periodontitis; continued use of anti-inflammatory and / or immunosuppressive medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-27bn6z	Immunogenicity and reatogenicity of Hepatitis B vaccine derived from Hansenula polymorpha compared to Saccharomyces cerevisiae in men deprived of their liberty	Recruitment completed	Intervention	2020-02-26	<NULL>	<NULL>	3530	Immunogenicity and reatogenicity of Hepatitis B vaccine derived from Hansenula polymorpha compared to Saccharomyces cerevisiae in men deprived of their liberty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Faculdade de Enfermagem Universidade Federal de Goiás	Fundação de Amparo à Pesquisa do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-27bn6z	<NULL>	"Susceptible to infection by hepatitis B virus infection (anti-HBs marker alone);
Being male;
Age between 18 years;
Prison regime in the Regional Prison of Itumbiara with penalty expected for more than eight months."	"To present any clinical picture that contraindicates hepatitis B vaccination;
Effect of substances that compromise the data response and the integrity of the researchers;
Medical diagnosis of mental disorders;
Present at the time of data collection behavior that endangers the physical and / or emotional health of the researcher.
To present difficulty of understanding in order to respond to the instrument of data collection (auditory deficiency and / or altered speech)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-7qjpn6	Educational technology for nursing education	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3531	Educational technology for teaching nursing diagnostic reasoning	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7qjpn6	<NULL>	being a graduate student in nursing; and, be enrolled in the fourth period of the undergraduate nursing course at that University.	"Not participating in all phases of the research; and have taken some discipline on diagnostic reasoning in nursing at another institution
University education"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-29495g	Application of exercises after cardiovascular surgery	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3532	Application of a mobilization protocol, based on the functional level, after cardiovascular surgery: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-27	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-29495g	<NULL>	Adults patients admitted to the ICU after cardiac surgery (myocardial revascularization, valve replacement / repair, correction of thoracic aortic diseases and combined procedures) or vascular surgery (revascularization of upper / lower limbs and correction of abdominal aortic diseases), from January 2020 to June 2021, with modified Barthel index for walking ? 4 will be included	"Cardiorespiratory arrest
 Brain injury, with motor response &lt;5 (Glasgow coma scale)
 Recent acute myocardial infarction
 Unstable fractures
 Pregnancy
 Medical guidelines for maintaining absolute rest due to patient severity
 Unable to understand verbal commands
 Mechanical ventilation time for more than 24 hours
 Enrollment in another clinical study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-98dxv3	Methods of controlling symptoms of temporomandibular dysfunction and bruxism	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3533	Effectives of different methods os interventions in TMD symptoms and Brussels - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Juliane Dias de Oliveira	Juliane Dias de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-98dxv3	<NULL>	Women will be included in the sample; older than 18 years; TMD symptomatology; bruxism reported and possessing smartphone.	Use of painkillers; antiinflammatories; botulinum toxin; myorelaxant plate for TMD treatment; in orthodontic treatment; who only have a diagnosis of bruxism or TMD.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-833mm2	Effect of acupuncture on fibromyalgia	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3534	Effect of systemic acupuncture associated or not with ear acupuncture in subjects with fibromyalgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Andreia Maria Silva Vilela Terra	Andreia Maria Silva Vilela Terra	https://ensaiosclinicos.gov.br/rg/RBR-833mm2	<NULL>	Women; age between 40 and 60 years; diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology (ACR 10)	Individuals with needle phobia; with hemorrhagic diatheses; pregnant or lactating women; individuals who are being treated with massage or acupuncture in the last two weeks before the intervention; or anesthetic drugs, analgesics, muscle relaxants or anti-inflammatory drugs in the last two days before the intervention; who have other associated pathologies and people with metallic implants; Tattoo; birthmarks; alteration of pigmentation at the site of the application of acupuncture points; I inserted olive oil with a lot of intensity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3csfjq	Efficacy of non-surgical treatment in patients with inflammation around teeth and implants without bone loss.	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3535	Efficacy of Non-surgical Treatment in patients with Gingivitis and Peri-implant Mucositis.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3csfjq	<NULL>	Present clinical diagnosis of mucositis peri implant, i.e., present probing depth of up to 5 mm, bleeding to the probing without evidence of radiographic bone loss in addition to the first two threads of implants; Be rehabilitated with unitary prosthesis, protocol or overdenture; Be partially or totally toothless; individuals who have been rehabilitated for at least 1 year. For cases of gingivitis, present clinical diagnosis of gingivitis in intact periodont, i.e., present probing depth less than or equal to 3 mm, 10% or more of sites with bleeding to the probing, absence of loss of insertion and bone loss Radiographic Patients presenting sites with probing depth of up to 3 mm, 10% or more of sites with bleeding to the probing, loss of insertion and possible radiographic bone loss; Patients with a history of treatment of periodontitis, therefore, presenting loss of insertion, sites with periodontal pouch of up to 3 mm, 10% or more of sites with bleeding to the probing and radiographic bone loss.	o present systemic complications, such as cardiovascular diseases, Alzheimer&apos;s, lung diseases, cerebral or metabolic syndromes;Have used antibiotics, anti-inflammatories, immunosuppressants or periodontal treatment in the last 6 months prior to the survey;Individuals who are in the gestational or breastfeeding period;Individuals who use orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9mj2dt	Effects of probiotics consumption for teratment of arterial hypertension	Data analysis completed	Intervention	2020-02-27	<NULL>	<NULL>	3536	Effects of supplementation with Probiatop (mixture of probiotics) in the treatment of arterial hypertension	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-08-03	FarmoQuímica	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9mj2dt	<NULL>	women diagnosed with primary systemic arterial hypertension (SAH) and aged 20 to 50 years.	"Age &lt;20 and&gt; 50 years;
Smoking;
Patients with other associated morbidities with the exception of Diabetes Mellitus;
Patients with a history of angina, acute coronary syndrome, changes in
left ventricular ejection fraction;
Patients with changes in liver enzyme levels or kidney failure
(creatinine&gt; 1.5 mg / dL);
Use of medications other than antihypertensives or
hypoglycemics;
Patient undergoing steroid or anticoagulant treatment, using
food supplements, with infections or neoplasia or other chronic pathology
known;
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-76ccw9	Effect of brain stimulation on the regulation of emotions	Recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3537	Effects of neurostimulation on emotional regulation: understanding the role of the pre-frontal cortex	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-76ccw9	<NULL>	University students, 18 to 40 years old, without psychiatric disorder, no history of brain surgery or brain tumor, contraindications for tDCS, no such as intracranial metal implantation.	People with signs of psychiatric disorder; under 18 and over 40 years; history of brain tumor or implant or brain surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3cpwwt	Acupuncture in pain patients with Chronic Kidney Disease	Recruitment completed	Intervention	2020-02-28	<NULL>	<NULL>	3538	Effect of Acupuncture on Chronic Renal pain patients in hemodyalysis: randomized trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-06-06	Geórgia Alcantara Alencar Melo	Geórgia Alcantara Alencar Melo	https://ensaiosclinicos.gov.br/rg/RBR-3cpwwt	<NULL>	"The criteria
for inclusion were: age between 30 and 60 years; with over a year of dialysis therapy; that is registered
in the clinic through the SUS; with moderate pain assessed from the analog pain scale; with punctuation
on the Glasgow scale of 15; with preserved hearing acuity through propaedeutic tests
Weber and Rinne Test); and preserved cognitive function assessed by the Mini Mental State Examination
(MEEM)."	"Mental deficiency diagnosed; use of another method of practice
complementary alternatives; use of opioids; have a dermatological lesion or absence of limb at the
application; and being pregnant. Discontinuity criteria: Participants wish not to continue in
research after first session; present any unpleasant reaction associated with the treatment; no
agree that needles are inserted at some point; have taken analgesic or relaxing medication
muscle in the last 12 hours prior to the session; no participation in two more acupuncture sessions, either for hospitalization, hemodialysis session absence or other reason."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3h6nkn	Effect of Speech Therapy on snoring in obese patients	Not yet recruiting	Intervention	2020-02-28	<NULL>	<NULL>	3539	Effect of Orofacial Myofunctional Therapy on the room of obese patients: ramdomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Estadual do Oeste do Paraná - Campus Cascavel	Universidade Estadual do Oeste do Paraná - Campus Cascavel	https://ensaiosclinicos.gov.br/rg/RBR-3h6nkn	<NULL>	Minimum age of 18 years; have a smartphone; accept sleeping in a room separate from the partner; agree to participate in the research by signing the Free and Informed Consent Form.	Non-availability to do the treatment for the established period; benzodiazepine medication users; continuous users of muscle relaxants; alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-5wwhss	Exercises to improve balance	Recruitment completed	Intervention	2020-02-28	<NULL>	<NULL>	3540	Strategies for health promotion in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Renan Nunes Aguiar	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-5wwhss	<NULL>	Being over 60 years old; under 90 years old; both sexes; being residents of the city of Sacramento / MG; consenting to participate in the research by signing the consent form	Elderly people with severe lower limb dysfunction; associated neurological diseases; individuals with visual changes without corrections or that make it impossible to see; musculoskeletal disorders that make it impossible to execute the proposed protocol; disorders of biomechanics; severe cognitive disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-235jx7	Impact of Dietary Composition and Resistance Training on Cardiovascular Risk Indicators and Android Adipose Tissue in Elderly Women	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3541	Study of Randomized Nutritional Intervention in Overweight Elderly People with Strength Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-235jx7	<NULL>	Overweight or obese elderly women (BMI&gt; 25kG / M²), elderly women who can eat high protein diets (without chronic kidney disease), elderly women without physical limitations (able to perform strength training) and elderly women without mental limitations or psychological (ensuring adequate understanding of nutritional guidelines), as well as elderly women who signed the consent form.	Elderly women with BMI &lt;25kG / M², elderly women who cannot eat high protein diets (chronic kidney disease patients), elderly women with physical limitations (unable to perform strength training) and elderly women with mental or psychological limitations ( ensure adequate understanding of nutritional guidelines), as well as older women who refused to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-6bqfp3	Laser to control bacteria that cause caries	Recruitment completed	Intervention	2020-03-02	<NULL>	<NULL>	3542	Evaluation of Antimicrobial Photodynamic Therapy in the control of bacterial dental biofilm in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6bqfp3	<NULL>	High risk for caries disease. Presence of teeth 36 and 46 completely erupted and with the buccal and lingual surfaces intact	Low or medium risk for caries disease. Spontaneous pain. Fistula. Caries lesion involving dentin. Systemic diseases. Antibiotic use in the last six months prior to the survey. Use of mouthwashes with auxiliary chemical substances to control biofilm and / or caries. Use of orthodontic appliances or prostheses. Dye sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-3fqtcx	Pilates and cognitive stimulation: Effects on cognition, functional perfomance and balance on old adults	Recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3543	Pilates and Cognitive Stimulation: Influences on Cognitive, Functional Perfomance and Balance on Old Adults	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2017-08-30	Universidade Federal do Pará	Laboratório de Investigações em Neurodegeneração e Infecção	https://ensaiosclinicos.gov.br/rg/RBR-3fqtcx	<NULL>	60 years of age or over; Medical releasing to the moderate physical exercise practice; Normal Mini-Mental State Examination (MMSE) scoring (adjusted for schooling).	Neurological diseases such as previous stroke, balance and coordination disorders due to cerebellopathy or labyrinthitis; Presence of musculoskeletal disordrs that limited to physical exercise; In use of drugs that act on the central nervous system at doses that may compromise cognitive or functional performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4dbvt7	Effectiveness of bleaching using violet led light	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3544	Effectiveness of bleaching with led photobleaching: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4dbvt7	<NULL>	Patients will be included in this clinical trial were men and women over 18 years; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-8cy8xb	Effect of consumption of beneficial bacteria associated with diet on body fat, intestinal health and aspects related to the immune system of obese people	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3545	Effect of probiotic supplementation associated with dietary intervention on body composition, intestinal microbiota and inflammatory biomarkers in adult individuals obese young people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Camila Guazzelli Marques	Departamento de Psicobiologia da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cy8xb	<NULL>	Male volunteers; sedentary; age between 20 to 40 years; body mass index (BMI) between 30.0 and 34.99kg / m2, which is obtained by dividing body weight, measured in kilograms, by the square height, measured in meters (kg / m2)	diabetics; vegetarians and vegans; accompanying with a nutritionist; performing any diet or food restriction; gastrointestinal surgery; using antibiotics in the last six months and anti-inflammatory drugs in the last fifteen days and the evaluation weeks; use of weight loss medications and/or antidepressants; use of drugs from the serotonin receptor family; regular consumption of probiotic/fermented products (kefir and kombucha); use of nutritional supplements (probiotics, prebiotics, symbiotics, multivitamins, omega-3, Whey Protein, and creatine); smokers; consumption of alcoholic beverages (&gt; 30.0 grams of alcohol per week); regular physical exercise at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-96dpjz	Association between pain, mastication and inflammation during treatment with different orthodontic appliances	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3546	Association between pain, mastigatory quality and inflammatory cytoxins in self-related appliances and aesthetic aligners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Aline Medeiros	Aline Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-96dpjz	<NULL>	age range from 12 to 35 years old; need for orthodontic treatment; with dental crowding between 4 and 8 mm in the upper arch; with proper oral hygiene; no caries; both sexes.	symptoms of temporomandibular joint dysfunction; chronic use of anti-inflammatory drugs or antibiotics; with periodontal disease with generalized probing depth of 3 mm at the test sites; with craniofacial anomalies; wearing orthodontic devices that cause discomfort.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-9qj37k	The role of preoperative fasting time reduction in post-surgical hip fracture correction complications	Recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3547	The role of preoperative fasting time reduction in post-surgical hip fracture correction complications	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Faculdade de Medicina da Unesp de Botucatu	Faculdade de Medicina da Unesp de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-9qj37k	<NULL>	Greater than 65 years; Proximal Femur Fracture	"Under 65 years; Diabetes; Chronic Kidney Failure
Pathological fracture; Infection; Carbohydrate and / or protein rich drink intolerance; Preoperative fasting time greater than 3 hours"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-8rs5kt	Myopia and Astigmatism Topography-guided Refractive Surgery by Contoura Method Versus Customized by Asphericity in Contralateral Eyes: A Prospective Double-blind Randomized Study	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3548	Femtolasik Topography-guided by Contoura Method Versus Customized by Asphericity in Contralateral Eyes: A Prospective Double-blind Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-05	Hospital de Olhos - Oftalmax	Hospital de Olhos - Oftalmax	https://ensaiosclinicos.gov.br/rg/RBR-8rs5kt	<NULL>	Patients of both sexes aged 20-35 years (avoiding possibly presbyopia patients), myopic with or without astigmatism, with stable refractive error for at least 1 year and visual acuity corrected away from 0.1 logMAR or better. The myopia may vary between -0.50 and -8.00 diopters (D) and the astigmatism between 0.00 and -3.00 cylindrical diopters (CD), with maximum spherical equivalent of 8.00D.	Patients with significant anisometropia, that is a refractive difference of 1 spherical diopter or 0.75 cylindrical diopters between the eyes, will be excluded from the study. Other exclusion criteria will be: presence of clinical signs of dry eye, abnormalities of the anterior segment - such as cataracts, scars or corneal neovascularization within 1.0 mm of the desired ablation zone, epithelial basement membrane disease, history of recurrent corneal erosions, progressive or unstable myopia, PAT (percentage of altered tissue) calculation above 35% of the corneal thickness at its finest point in the ablation calculation19,24, pachymetry below 500, suspected keratoconus in its subclinical or stablished form, macular or retinal disease, diagnosis of glaucoma or ocular hypertension, current use of systemic corticosteroids or immunosuppressive therapy, collagen diseases, vascular diseases, diabetes mellitus types I and II, pregnancy and breastfeeding. The patient who presents any type of intraoperative intercurrence will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4hxs2g	Resistance exercise during hemodialysis session	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3549	Effect of physical exercise on hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-20	Universidade Estadual Paulista &quot;Julio de Mesquita Filho&apos;	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-4hxs2g	<NULL>	Be over 18 years old; have been on hemodialysis for at least three months; patients without medical records of event, symptom or heart disease, such as acute myocardial infarction, coronary insufficiency with presence of ischemia and / or angina, arrhythmias and stroke; without medical contraindication to physical exercise.	Exclusion criteria: individuals with mobility difficulties; blind, amputated, change in hemodialysis shift, people who received kidney transplant and individuals in wheelchairs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-3rj7tt	Effect of the weekly frequency, with equalized volume, of the Strength Training with instability on the functional capacity of elderly people	Recruiting	Intervention	2020-03-03	<NULL>	<NULL>	3550	Effect of weekly frequency with equalized volume of Strength Training on unstable surface on neuromuscular capacity, quality of life and fear of falling in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3rj7tt	<NULL>	Participants must be 60 years of age or older, have not practiced strength exercises for at least 6 months, have no disabling diseases and be able to understand and make study commitments	Individuals who do not have the time to participate in the experimental and elderly groups that are currently participating in another exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-2qkx69	Effect of physical exercise on functionality and molecular markers in institutionalized elderly	Recruitment completed	Intervention	2020-03-03	<NULL>	<NULL>	3551	"Effect of Physical Exercise on Clinical Functional outcomes
and modulation of Epigenetic Markers in institutionalized elderly"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2qkx69	<NULL>	"age over 60 and have
ability to walk without bracing"	"Make use of medicines containing HDAC inhibitor such as Acid
Valproic, have other associated neurological diseases, problems
orthopedic and / or musculoskeletal disorders that affect gait, cognitive impairment
Mini Mental State Examination (MMSE), inability to
communicate with investigators or have no medical clearance to perform
physical activity"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-74pcmw	Effects of different intensities of Resistance Training, Walking and Stretching in patients with Fibromyalgia Syndrome	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	3552	Effects of different intensities of Resistance Training, Walking and Stretching in patients with Fibromyalgia Syndrome: randomized controlled trials	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-10	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-74pcmw	<NULL>	"Clinical diagnosis of fibromyalgia; Women;
Over 18 years old; Medical certificate for physical exercise"	Present some incapacitating disease for physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-3gt65c	Effect of resveratrol on periodontal disease treatment of smokers.	Recruitment completed	Intervention	2020-03-03	<NULL>	<NULL>	3553	Effect of resveratrol on non-surgical periodontal treatment of smokers diagnosed with Chronic Periodontitis. Prospective evaluation of clinical, microbiological, immunological results and quantification of neutrophils.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-11	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3gt65c	<NULL>	Diagnosis of generalized chronic periodontitis with at least 8 teeth with Probing Depth (PD) and Clinical Attachment Level (CAL) equal to or above 5 mm and Bleeding on Probing. Of these 8 teeth chosen, at least two teeth should present PD and CAL equal to or above 7 mm; Presence of at least 20 teeth in the oral cavity;Smoking cigarette for at least 5 years and at least 10 cigarettes per day.	Periodontal treatment in the 6 months prior to the study; Use of medications, such as antibiotics, continuous anti-inflammatories, phenytoin, cyclosporine, in the 6 months prior to the study; Presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.); Pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4nq793	Evaluation of whitening and depression on tooth surface after action of whitening toothpastes	Recruitment completed	Intervention	2020-03-03	<NULL>	<NULL>	3554	Bleaching effect and superficial roughness evaluation of whitening  toothpastes during two months follow-up in vivo	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Estadual de Campinas	Faculdade Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4nq793	<NULL>	Volunteers between 18 and 30 years old; independent of gender; with no periodontal disease and caries free; that never bleached their teeth; have no systemic disease and no anterior teeth restoration.	Natural white teeth (B1 or A1 in Vita Classical scale, VITA, Bad Säckingen, SWZ); poor oral hygiene; allergies to any of the products; chronic medicine needs; smoking habits; drugs addiction; caries lesion; extensive posterior restoration and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-487ctp	Comparison of two treatment options for patients with precursor lesions of skin cancer: colchicine cream versus 5-FU cream	Not yet recruiting	Intervention	2020-03-03	<NULL>	<NULL>	3555	Clinical and dermatoscopic evaluation of the effectiveness of Colchicine 0,5% cream versus 5-Fluorouracil 5% cream in the treatment of Actinic Keratosis and Cutaneous Cancerization Field: a randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-03-17	Instituto Lauro de Souza Lima (ILSL)	Faculdade de Medicina da Universidade Estadual Paulista (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-487ctp	<NULL>	Sign the Informed Consent Form; age over 18 years, both sexes; present a minimum of 3 and a maximum of 10 lesions clinically compatible with AK on each dorsal face of the forearm.	Exclusion criteria: treatment area that has an atypical clinical appearance, suggestive of carcinoma, or other extensive dermatoses; current and / or previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; patients using any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (eg: corticosteroids, anti-inflammatories, topical retinoids); patients who have received any type of treatment for skin field cancerization less than 6 months before the start of the study; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women of childbearing potential who do not use contraception; women who are breastfeeding. Discontinuation criteria: withdrawal of consent; presence of infection (erysipelas, cellulitis or abscess) during follow-up in the treatment areas; loss of follow-up; use of other AK treatment methods other than the one proposed; serious adverse event, at the investigator&apos;s discretion; pregnancy during follow-up; failure to take photographic images of the lesions on the days determined before the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-3sq5hv	Three-dimensional assessment of facial growth of severe upper airway obstruction children after adenoid and tonsills surgery	Data analysis completed	Observational	2020-03-03	<NULL>	<NULL>	3556	Three-dimensional assessment of facial growth of severe upper airway obstruction children after adenotonsillectomy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-09-15	Universidade Federal de Minas Gerais	Faculdade de Medicina Dentária de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-3sq5hv	<NULL>	"children with OSA diagnosed by polissonography;  
Brodsky&apos;s grade 3 or 4 palatine hypertrophy tonsils;adenoid hypertrophy above 75% confirmed by nasopharyngo-laryngoscopy;indication of adeno/-tonsillectomy"	Children with genetic syndromes and neuromuscular disease; children with a perforation of the nasal septum and/or craniofacial alterations; children diagnosed of pulmonary hypertension due to heart disease or with a previous history of adenotonsillectomy;children who could not be submitted to the examinations proposed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4m6x29	Rehabilitation for Sensory disorders of the larynx: clinical trial	Recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3557	Sensory disorders of the larynx: diagnosis and rehabilitation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4m6x29	<NULL>	Brazilians; age over 18 years; both sexes; persistent cough for more than 8 weeks (CARROLL, 2019); refractory to treatment (CARROLL, 2019); presence of complaints related to laryngeal dysfunction syndromes (VERTIGAN; BONE; GIBSON, 2014); who adhere to the Informed Consent Form.	Clinical history of neurological, cognitive or psychiatric disorders that make it impossible to understand the procedures performed in the study; upper airway infection on the day of assessment; untreated asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-9wfww5	Radiofrequency within the vagina in the treatment of involuntary urine loss: Randomized clinical trial	Not yet recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3558	Transvaginal radio frequency in the treatment of urinary incontinence: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Programa de Pós-Graduação em Gerontologia Biomédica da Pontifícia Universidade Católica do Rio Grande do Sul	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9wfww5	<NULL>	Women from the PUC gynecology outpatient clinic who are post menopausal, with a diagnosis of stress urinary incontinence or mixed stress urinary incontinence will be included, who have no urinary infection on urine examination and want to participate in the study.	Desire for surgical treatment for urinary incontinence, pelvic tumors, pelvic prolapses grade III and IV, previous surgery for urinary incontinence or genital prolapse, neurogenic bladder, patients with cardiac pacemakers and undergoing parallel physiotherapeutic treatment for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4n5mkh	Oral Estrogen use in treatment of women with Acromegaly	Recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3559	Evaluation of the efficacy and security of oral Estrogen use in the treatment of female patients with Acromegaly	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-09-29	Instituto Estadual do Cerebro Paulo Niemeyer	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4n5mkh	<NULL>	Patients of childbearing age who had a desire for contraception and who agreed to use oral contraceptives were included. All participants were uncontrolled with IGF-I concentration above the upper limit of normal range (ULNR) for age, and with a random GH level above 1 ng/ml.	The study exclusion criteria included contraindications to oral contraceptive use such as cerebrovascular or coronary artery disease; history of deep vein thrombosis, pulmonary embolism, or congestive heart failure; untreated or uncontrolled hypertension (relative contraindication: systolic blood pressure 140-159 or diastolic 90-99; absolute: ? 160mmHg or ? 100mmHg); breast cancer; estrogen-dependent neoplasia, undiagnosed abnormal genital bleeding, known or suspected pregnancy, benign or malignant liver tumors; active liver disease; smoking; diabetes with vascular complications; renal failure with glomerular filtration rate below 30ml/min.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-32b22n	Comparison of the effect of two different irrigation methods on pain that occurs after root canal treatment	Recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3560	Postoperative Pain after use of two different Final Irrigation protocols: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de São Paulo - Faculdade de Odontologia de Bauru	Centro Especializado de Odontologia - Prefeitura Municipal de Vitória da Conquista	https://ensaiosclinicos.gov.br/rg/RBR-32b22n	<NULL>	Single root canals teeth; diagnosed with pulp necrosis and evidence of apical periodontitis; with radiolucency not exceeding 4 mm in diameter	Patients who have one or more of the following conditions: systemic disease; pregnant women; allergies to local anesthetics; presence of severe or acute pain; acute apical abscess; use of analgesic, anti-inflammatory, or antibiotic for 7 days prior to treatment; periodontal pockets greater than 4 mm associated with the referred tooth; teeth with subgingival caries that make absolute isolation difficult; and a history of unfinished endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7ncyyw	Effects of functional training on blood and salivary components and blood pressure of older women	Recruitment completed	Intervention	2020-03-05	<NULL>	<NULL>	3561	Effects of functional training on biochemical and hemodynamic aspects in older women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Faculdade de Medicina - UFU	Faculdade de Educação Física - UFU	https://ensaiosclinicos.gov.br/rg/RBR-7ncyyw	<NULL>	Belonging to females; Be between 60 and 80 years old; Not to be a smoker; Not practice physical exercise regularly and systematically for at least three months; Have a BMI below 32 kg / m²; Not present musculoskeletal problems or cardiovascular complications that prevent the practice of systematic physical exercises; Submit a medical assessment involving a clinical history and medical certificate.	Belonging to males; Be less than 60 or more than 80 years old; Be a smoker; Be exercising regularly and systematically; Have a BMI equal to or above 32 kg / m²; Have musculoskeletal problems that prevent the practice of physical exercises; Have a history of stroke or acute myocardial infarction; Not present medical evaluation and certificate for the practice of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7ffw9k	Guidance and Physiotherapy in the treatment of patients with Acute Low Back Pain	Not yet recruiting	Intervention	2020-03-05	<NULL>	<NULL>	3562	Minimal Intervention vs. Physical Therapy in the treatment of patients with Nonspecific Acute Low Back Pain: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federeal de São Paulo - UNIFESP	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7ffw9k	<NULL>	Patients diagnosed with acute nonspecific low back pain; both genders; age between 18 and 60 years; who agree to participate in the research and sign the IC.	Patients with a history of previous spine surgery; who have undergone physical treatment for low back pain in the past six months; who present clinical warning signs for the presence of fractures, tumors or infections and for the presence of inflammatory, pelvic and abdominal diseases; patients with the presence of associated neurological symptoms indicative of radiculopathy; patients who have contraindications to the use of anti-inflammatory drugs; pregnant women; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-8khknz	Sleep pattern profile in professional e-sports athletes (league of legends)	Recruitment completed	Intervention	2020-03-05	<NULL>	<NULL>	3563	Sleep pattern profile in professional e-sports athletes (league of legends)	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-06-10	Faculdade de Ciências Aplicadas - FCA	Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-8khknz	<NULL>	healthy volunteers; male; league of legends players for over 1 year	women; history of alcohol or drug abuse; league of legends players under the age of 1 in the game	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3sstqg	Impact of a cognitive behavioral program on the quality of life of men with urinary incontinence radical prostatectomy: a randomized clinical trial	Recruiting	Intervention	2020-03-05	<NULL>	<NULL>	3564	"Urinary incontinence and quality of life in men undergoing prostatectomy
radical"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-3sstqg	<NULL>	"In order to compose the sample, the following inclusion criteria will be adopted:
Age equal or superior to 18 years;
Diagnosis of prostate adenocarcinoma;
Schedule for PR at the institution included in the study;
Agree to participate in the research;
Present clinical conditions physical and psychological to answer the questions asked by the researcher;
To report locomotor capacity for pelvic floor strengthening exercises;
Have a telephone landline or cell phone to follow the teaching program;
To present cognitive capacity for participation - application of mini mental state examination BERTOLUCCI et al., 1994."	"In order to compose the sample, the following exclusion criteria will be adopted:
Participants presenting with spinal cord injury, diabetes mellitus, stroke, dementia, Alzheimer&apos;s disease, previous pelvic surgery, diseases with a probable repercussion on urinary control;
Participants with a history of bladder and / or prostate surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3875dd	Effectiveness and safety of yellow fever vaccination in patients with rheumatic diseases	Recruiting	Observational	2020-03-05	<NULL>	<NULL>	3565	Immunogenicity and safety of primary yellow fever vaccination in patients with rheumatic diseases	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital Universitário Cassiano Antônio de Moraes	Hospital Universitário Cassiano Antônio de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-3875dd	<NULL>	The present study included patients with rheumatic diseases including Rheumatoid Arthritis, Systemic Erythematosus Lupus, Sjögren Syndrome, Systemic Sclerosis and Spondylarthritis over 18 years of age  who received yellow fever 17DD anti-mammalian first vaccination in the 2017 Brazilian Campaign from January until December 2017. The control group consisted of individuals who spontaneously searched the Rheumatology Service of HUCAM to receive yellow fever first vacination YF 17DD antimammalian Biomanguinhos-FIOCRUZ in the 2017 Brazilian Campaign and who did not have immune mediated rheumatic disease and no history of previous yellow fever vaccination.	Exclusion criteria included patients under 18 years of age, patients with history of previous yellow fever vaccination, patients external to HUCAM who have not been referred by a rheumatologist by letter or direct contact of the attending physician indicating the diagnosis and medications in use, those who do not agree to participate; patients immunosuppressed by other causes such as HIV infected, CD4 count less than 200 cells per mm3, organ transplantation history, primary immunodeficiency, neoplasia, previous history of timus disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7mn7yj	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	Data analysis completed	Intervention	2020-03-04	<NULL>	<NULL>	3566	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-09-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7mn7yj	<NULL>	with moderate to severe COPD, (post-bronchodilator FEV1&gt; 30% and predicted &lt;80%)	"Exclusion criteria were:
 indication and / or use of chronic home oxygen therapy, inability to perform physical tests, symptomatic coronary disease, musculoskeletal limitation and neurological disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9srx44	Effects of ozone therapy on management of pain, swelling, and trismus following mandibular third molar surgery	Terminated	Intervention	2020-03-06	<NULL>	<NULL>	3567	Effects of ozone therapy on management of pain, swelling, and trismus following mandibular third molar surgery	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-04-10	renato baiao de almeida	renato baiao de almeida	https://ensaiosclinicos.gov.br/rg/RBR-9srx44	<NULL>	pacients with 18 years old or more; without sitemic diseases and with included mandibular third molar on class ll B on the PELL-GREGORY/ WINTER classification score of difficulty of removing.	the exclusion critter is  contra-indication of ozone therapy, systemic diseases, local infection, tabagismo, oral contraceptives users, pregnant, lactate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-55bc85	Lactobacilli associated with antibiotics in the treatment of periodontitis in smokers	Not yet recruiting	Intervention	2020-03-06	<NULL>	<NULL>	3568	Antibiotic associated with probiotic in the treatment of chronic periodontitis in smokers	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-55bc85	<NULL>	Patients aged between 30 and 70 years old; diagnosis of severe generalized chronic periodontitis; heavy smokers (more than 10 cigarettes per day for more than 5 years) and at least 15 teeth in mouth, excluding third molars.	Medical disorders that require antibiotic prophylaxis or who could influence the response of the treatment; having received treatment for periodontal scaling and root planing in the last 6 months; having consumed drugs that affect the periodontal tissues in the last 6 months (antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants or calcium channel blockers); pregnancy; prosthetic rehabilitations extensive carrier; in orthodontic treatment; patients with metabolic disorders such as diabetes; immune disorders; alcohol and illicit drug use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3r2kv9	Impact of the maternal diet and the supplementation of fibers on the breast milk bacteria	Data analysis completed	Intervention	2020-03-06	<NULL>	<NULL>	3569	Impact of the maternal diet and the intervention with fructooligosaccharides on the human milk microbiota	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade de São Paulo	Hospital Universitário da Universidade de Sâo Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3r2kv9	<NULL>	Healthy lactating women having term babies (born between 37 and 42 weeks), with adequate weight for gestational age; having normal bowel frequency (minimum once every 2 days, maximum 3 times per day).	"No chronic gastrointestinal disease; genetic disease; cardiac disease; kidney disease; hypertension; diabetes mellitus or immunodeficiency diseases; eclampsia or gestational diabetes during pregnancy; mastitis during the lactation period;
have taken proton pump inhibitors; H2 receptor antagonists; antidepressants; narcotics; anticholinergic medications; laxatives, or anti-diarrhea medications within 30 days prior to collection the milk samples; regular consumption of commercially available, prebiotic- or probiotic supplemented product."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7pcxzt	Influence of different solvent evaporation temperatures of the adhesive system on the effectiveness of single fill composite resins - Randomized clinical trial	Recruitment completed	Intervention	2020-03-06	<NULL>	<NULL>	3570	Influence of different volatilization temperatures of the adhesive system on the effectiveness in resin restorations Bulk Fill - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-20	Universidade do oeste paulista	Faculdade de Odontologia de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-7pcxzt	<NULL>	Need for restorative treatment in posterior teeth in even number; class I; shallow cavity; pulp vitality; carious lesions; fracture of restorations or replacement of restorations for aesthetic reasons; 18 to 25 years of age, both genders	ístimo that surpass ½ of the distance intercuspídica; Medium, deep, or very deep carious restorations; High activity of caries; Parafunctional habits; need for prior periodontal treatment; Absence of occlusion with an antagonist tooth; absence of proximal contact on both sides.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-744pfs	The Effect of the application of Mustard Seeds on specific points of the ear of patients with back pain	Recruitment completed	Intervention	2019-06-10	<NULL>	<NULL>	3571	Effects of Auriculotherapy With Mustard Seeds on Chronic Lumbar Pain of Nursing Professionals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Ana Paula Gomes da Silva	Ana Paula Gomes da Silva	https://ensaiosclinicos.gov.br/rg/RBR-744pfs	<NULL>	Female nursing technical and  auxiliaries professionals of the adult wards of the Hospital das Clínicas-UFPE that provide direct care to hospitalized patients. BMI between 18.5 and 29.9. Age range between 20 and 50 years of age. Chronic lumbago (3 months ago). Self-declaration of absence of a herniated disc, malignant tumor of any type, degenerative, infectious or rheumatic disease (rheumatoid arthritis and ankylosing spondylitis), or previous self-reported lumbar spine surgery.	Pregnant women and infants. Allergic to micropore plaster. Professionals who perform only bureaucratic activities other than direct care for inpatients. Not performing the four sessions of auriculotherapy weekly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9s93d9	Is mindful breathing meditation worth it for obese patients under nutritional orientation? Evaluation of stress perception, anthropometry, and autonomous balance in a Brazilian sample.	Data analysis completed	Intervention	2020-03-08	<NULL>	<NULL>	3572	Association of guided meditation and nutritional orientation for obese patients.	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2017-04-04	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9s93d9	<NULL>	Female patients; with an age range between 21 and 59 years; BMI ? 30 kg/m²; who accepted to participate the study.	diagnosed Diabetes; diagnosis of any psychiatric disorder; being pregnant or suspicious of being pregnant; having a pacemaker or any other electronic devices inside of the body; having a metallic prosthesis inside of the body; or not agreeing to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9rhyjn	Postoperative urinary retention in orthopedic patients	Data analysis completed	Intervention	2020-03-08	<NULL>	<NULL>	3573	Acute postoperative urinary retention in orthopedic patients undergoing Spinal Anesthesia with Morphine versus Spinal Anesthesia without opioid associated with Peripheral Nerve Block: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-23	Carolina Lourenzon Schiavo	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9rhyjn	<NULL>	Patients over 18 years of age; undergoing elective orthopedic surgeries of the lower limbs at the Hospital de Clinicas de Porto Alegre; with acceptance and signature of the free and informed consent term; with the possibility of performing the surgical procedure under spinal anesthesia; a minimum hospital stay forecast of 24 hours.	Patients with a history of urological problems; severe cognitive disorders;  patients who were unable to urinate spontaneously before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3sgkd9	Nutritional status of iodine, sodium and potassium among Brazilian pregnant women, lactating women and infants: a multicenter study	Recruiting	Observational	2020-03-08	<NULL>	<NULL>	3574	Nutritional status of iodine, sodium and potassium among Brazilian pregnant women, lactating women and infants: a multicenter study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-05-22	Ministério da Ciência, Tecnologia e Informação	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-3sgkd9	<NULL>	Will be considered eligible for research pregnant women, lactating women, and infants users of the public health network of the city of Ribeirão Preto - SP.	Women with a history of thyroid disease (hypothyroidism, hyperthyroidism, Hashimoto&apos;s disease and neoplasms) and / or thyroid surgery will not be included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-7nnrdv	Acute effect of the squat exercise on the guided bar performed with different training strategies on the risk of falling in elderly women with no experience in resistance training	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3575	Acute effect of different strength exercise configurations on functional capacity and risk of falling in untrained elderly women: a randomized crossover study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7nnrdv	<NULL>	women; age between 60 and 75 years; postmenopausal women with an interval greater than or equal to 12 months in relation to the last menstruation; have not undergone hormone therapy until 3 months before the study; not having a heart transplant; using a pacemaker or having arrhythmias; present a body mass index (BMI) between 25 and 30 kg / m2; be classified as “Active” according to the international physical activity questionnaire (IPAQ) long version; functionally independent (greater than 103 points in the general score) according to the Functional Independence Measure - MIF and not being strength training practitioners; not having any medical contraindication for physical exercise (eg, fractures, surgeries and / or osteo-myo-articular injuries); non-diabetic or with controlled diabetes; normotensive or controlled hypertension less than 150/100 mmHg; 10) without infectious diseases; have the cognitive performance evaluated positively (illiterate between 20 and 24 points; 1 to 4 years of schooling between 25 and 26 points; from 5 years of schooling between 26 and 27 points; from 9 and 11 years of schooling with 28 points; and greater than or equal to 11 years of schooling with greater than or equal to 29 points) through the Mini Mental State Examination - MEEM; no vestibular problems and complaints of dizziness according to the Dizziness Handicap Inventory - DHI questionnaire.	do not obtain frequency of 100% of the proposed visits; reporting consumption of dietary supplements; alcoholic beverages 24 hours before the scheduled visit; diseases that make it impossible for them to continue in the training program (eg, musculoskeletal or cardiovascular aggravation); and obtain inadequate completion of any of the tests, as well as the experimental sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-8py422	Evaluation of the gingiva using fixed orthodontic retainers	Recruitment completed	Observational	2020-03-09	<NULL>	<NULL>	3576	Periodontal evaluation of two orthodontic retaining models: an observational study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8py422	<NULL>	Present a good alignment of the lower anterior elements; be between 18 and 25 years old; have already undergone orthodontic treatment.	Being under orthodontic treatment; presenting with periodontal disease; having severe crowding between the anterior teeth of the jaw.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-2t9y4p	Effects of Intradialitic Exercise in patients with Chronic Kidney Disease	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3577	Effects of different modalities of intradialitic Exercise on aerobic capacity and quality of life of Chronic Kidney Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal da Bahia(UFBA)	Hospital Geral Roberto Santos(HGRS)	https://ensaiosclinicos.gov.br/rg/RBR-2t9y4p	<NULL>	Chronic renal patients on dialysis who come to the hospital only to undergo hemodialysis sessions; hemodynamically stable(without vasoactive drugs), with medical clearance to perform physical exercises during the hemodialysis session; able to perform cycle ergometer and / or resisted exercises; older than 18 years; who walk without assistance.	Patients who have difficulty understanding the commands requested during physical exercise will be excluded, which will be evaluated by the Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-2w526q	Strengh and electrical activity measurements of expiratory muscles in neurological subjects	Recruitment completed	Intervention	2020-03-09	<NULL>	<NULL>	3578	Evaluation of the specific process of withdrawal of mechanical ventilation in patients suffering from severe traumatic brain injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM-UNICAMP)	Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM-UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-2w526q	<NULL>	Men ou women of 18 to 61 years old; diagnosis of traumatic brain injury ou stroke (ischemic or hemorrhagic); under invasive mechanical ventilation by orotracheal tube or tracheostomy; in spontaneus modality after successful Spontaneous Breathing Test.	People or responsibles who do not agree or sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-6hwx3k	Self-monitoring for women&apos;s empowerment to reduce the risks of high blood pressure during life, after a pregnancy with specific high blood pressure	Not yet recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3579	Self-monitoring to empower women to reduce the risk of hypertension later in Life After a Pregnancy with Preeclampsia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-14	Unesp - universidade estadual paulista	Fapesp - fundação de amparo a pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6hwx3k	<NULL>	Postpartum patient; age 18 or over; diagnosis of preterm preeclampsia in pregnancy and smartphone and internet access;	Multiple pregnancy; presence of comorbidities, including kidney disease, active liver disease (hepatitis), heart disease, diabetes mellitus and other comorbidities requiring individualized follow-up and women who start a new pregnancy during the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3dw33z	Effect of an Aquatic Training (Egg Beater) on the Hip Rotator Muscles	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3580	Effect of Water Polo Training (Egg Beater) on Hip Rotator Muscles Performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-03	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3dw33z	<NULL>	Healthy and sedentary volunteers; both genders; age between 18 and 60 years; not having undergone surgical procedures; not having undergone hip rehabilitation; not having undergone a musculoskeletal injury to the lower limbs / trunk in the last 6 months; perform less than 2 days a week of muscle strengthening or resistance activities; know how to swim; present minimum clinical and cognitive conditions for performing activities in the pool through the Physical Activity Readiness Questionnaire (PAR-Q); not presenting contagious dermatological changes; urinary and fecal incontinence.	Failure to perform the passive stiffness test of the hip lateral rotators; at the request of the volunteer himself; changes in the routines of the volunteers in the control group, lack of more than 15% in the interventions. Presence of muscle contraction during the passive RL stiffness test of the hip. Pain reported during the procedure that prevents its correct execution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-88cjpb	Automated screening to assess and manage the use of alcohol, tobacco and other substances	Not yet recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3581	Feasibility and acceptability of implementing an automated self-screening to assess and manage the use of alcohol, tobacco and other substances	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Raquel Brandini De Boni	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-88cjpb	<NULL>	HIV-positive individuals; with 18 years or more; under care at INI-FIOCRUZ; who are included in the HIV-INI cohort	NA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-84z83n	Functional effect on cardiovascular and neurological health of Passiflora setacea passion fruit species in overweight sedentary individuals	Recruitment completed	Intervention	2019-10-23	<NULL>	<NULL>	3582	Leukocyte gene expression response, monocyte adhesion, neuronal response and metabolite excretion in healthy individuals after Passiflora setacea pulp consumption: a nutrigenomic, metabolomic and in vitro approach	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade de Brasília	INRA - Institut National de la Recherche Agronomique	https://ensaiosclinicos.gov.br/rg/RBR-84z83n	<NULL>	Healthy subjects; males; aged between 40 and 64 years; overweight (BMI between 25 and 30 kg/m2 or waist circumference greater than 94cm).	Smokers; practitioners of physical activity over 5h per week; passion fruit allergic and fruit-based products; supplement users in the two months prior to the experiment (vitamin C, multivitamins, antioxidant capsules, etc.); medication users for chronic treatments (antihypertensive, antihyperglycemic, anticholesterol, antidepressant, sleep aid, anxiolytic, etc.), acute treatments in the 15 days prior to the experiment (potent anti-inflammatories, antibiotics, etc.); acute treatments in the two days prior to the experiment ( anti-inflammatory pain relievers such as aspirin, acetaminophen, etc.).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3xwprn	Fracture Prevention in Permanent Molars with Developmental Defects of Enamel	Recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3583	Effectiveness of Sealing of Pits and Fissures in Hypomineralized First Permanent Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-09	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3xwprn	<NULL>	Healthy children, 7 to 10 years-old, with molar incisor hypomineralization diagnosed according to the European Academy of Pediatric Dentistry criteria. Patients must present at least one permanent first molar with creamy-whitish or yellow-brownish demarcated opacity without post-eruptive breakdown or dentin caries.	Children with other enamel developmental defects than molar incisor hypomineralization, with fixed orthodontic appliance or who are unable to cooperate during dental treatment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-2bfthr	Non-dialytic chronic kidney disease patients treated with n-acetylcysteine and folic acid: evaluation of the antioxidant potential of drugs used by these patients.	Recruitment completed	Intervention	2020-03-09	<NULL>	<NULL>	3584	Clinical trial with folic acid associated n-acetylcysteine in patients with pre-dialytic chronic kidney disease: analysis of inflammatory and oxidative stress biomarkers and in vitro evaluation of the antioxidant potential of commonly used drugs in this	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2bfthr	<NULL>	Patients of both sexes; aged over 18 years in full cognitive condition; with no comorbidities that prevent participation in this study and who have glomerular filtration rate (GFR) according to those described according to the National Kidney Foundation (2015); to determine the stage of CKD: 3a - GFR of 59-44 mL / min / 1.73 m2; 3b - GFR of 44-33 mL / min / 1.73 m2; 4 - GFR of 29-15 mL / min / 1.73 m2	Patients with chronic viral infection; autoimmune disease and malignancy; treatment with antioxidants or anti-inflammatory drugs will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-8tsktw	The practice of physical exercises with high cognitive demand associated with brain stimulation improves cognitive and physical functions in elderly people with Alzheimer&apos;s	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3585	"The Influence of the Association between Non-Invasive Brain Stimulation and Exercise
Physicians with High Cognitive Demand in Cognitive and Functional Variables in the Elderly
with Alzheimer&apos;s"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	MINISTÉRIO DA CIÊNCIA, TECNOLOGIA, INOVAÇÕES E COMUNICAÇÕES	Istitutos Superiores de Ensino do CENSA	https://ensaiosclinicos.gov.br/rg/RBR-8tsktw	<NULL>	Age equal to or greater than 60 years; of both sexes; having an early stage Alzheimer&apos;s diagnosis or mild cognitive decline; volunteer to participate in the study.	Elderly people who have any physical limitations that prevent participation in moderate to low intensity exercises; Have minimally preserved cognitive ability to understand the study procedures; elderly who are not served by the reference center where the research will be developed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-8fdwth	Effect of aerobic training combined with strength training with an elastic tube on the functional capacity of the elderly	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3586	Functional, hemodynamic and neuromuscular modifications in hypertensive subjects submitted to concurrent training and resistance training with elastic tube	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Santa Catarina	Programa de Pós-graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-8fdwth	<NULL>	The inclusion criteria were: age equal to or greater than 50 years; not practicing systematic training in the last 6 months and; have medical clearance for physical exercise.	Individuals were excluded if any disease that could be aggravated by training; muscle or joint limitations; did not reach 85% of the total number of planned sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-5hjcyb	Effect of resveratrol associated with eriodontal treatment of patients with aggressive periodontitis.	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3587	"Influence of resveratrol associated with non-surgical periodontal treatment of
patients with aggressive periodontitis. Clinical, microbiological and
enzyme immunoassay."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5hjcyb	<NULL>	"Diagnosis of generalized aggressive periodontitis verified by the presence
of true periodontal pockets and radiographic bone loss in patients up to 35 years of age, according to the criteria established by the Academy American Periodontics in 1999; Presence of at least eight teeth with probing depth equal to or above 5 mm (of which two teeth should have probing pocket depth iqual to or above 7 mm) and bleeding on probing;
Presence of at least 20 teeth in the oral cavity; Group approaches: Presence of at least two residual periodontal pockets, on posterior teeth without furcation involvement, with probing depth iqual to or above  5 mm and bleeding on probing, three months after non-surgical periodontal treatment."	"Periodontal treatment in the 6 months prior to the study; Use of medications, such as antibiotics, anti-inflammatory drugs
continuous use, phenytoin, cyclosporine, in the 6 months prior to the study; Presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.);
Presence of smoking habit; Pregnancy or breastfeeding; Group approaches: Presence of furcation injury; Presence of periapical or pulp changes; Presence of systemic changes or use of medications (6 months prior to the study) that may influence the response to periodontal treatment; Smoking patients; pregnant patients; Patients taking medications such as corticosteroids and antibiotics."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-64vgjd	Evaluation of bone repair using a blood concentrate	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3588	Evaluation of bone repair after exodonties of third molar included with leukocytes platelets  rich in fibrin (L-PRF)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-10	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-64vgjd	<NULL>	The established inclusion criteria are: age between 18 and 35 years old;  no systemic disease; not to use medications that interfere with the procedure on the day or week prior to the research; present surgical site without current signs and symptoms of infection; agree to participate in the experiment; present lower third molars in similar positions.	Patients with: (1) history of pregnancy or lactation, (2) history of allergy to any drug used in the experiment; (3) not participate in all phases of the proposed research; (4) and not having the lower second molars.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-6rvjd2	Intraocular Amphotericin B and Voriconazole in fungal Keratitis treatment	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3589	Intracameral injection of Amphotericin B and Voriconazole in fungal keratitis treatment	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-12-17	Departamento de Oftalmologia Universidade Federal de São Paulo	Departamento de Oftalmologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6rvjd2	<NULL>	Patients with suspected fungal keratitis, with positive or ongoing culture, who do not show clinical improvement after 10 days of topical antifungal treatment or with anterior chamber involvement	Age under 12 years, affection limited to the anterior third of the corneal stroma; presence of corneal perforation, atalamy or scleral involvement; patients or guardians who do not agree to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-2d56bt	Effects of Functional Training on the immune system and inflammatory responses, body composition and functionality in Overweight elderly women	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3590	Effects of Functional Training on immunological and inflammatory parameters, body composition and functionality in Overweight elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	José Carlos Aragão Santos	José Carlos Aragão Santos	https://ensaiosclinicos.gov.br/rg/RBR-2d56bt	<NULL>	Being female. At least 60 years of age. Be physically independent. Have a body mass index greater than 24.9 kg / m². Obtain a minimum score of 14 on the mini mental state exam (FOLSTEIN et al., 1975). Absence of musculoskeletal or cardiovascular disorders that make it impossible to perform high-intensity physical exercises. Be at least six months without performing any regular physical activity.	Attendance rate below 80%. Miss any of the evaluation sessions. Begin some type of regular exercise practice in addition to that proposed in this work during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-877t2w	Study to compare the effectiveness of Lotion and Calendula Cream versus Chamomile Cream in an attempt to prevent Skin Reactions in patients with Breast Cancer	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3591	Phase II randomized study to compare the Efficacy of Radiodermatitis Prophylaxis between Lotion and Calendula Cream versus Chamomile Cream in patients with Breast Neoplasia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-09	Hospital de Amor de Barretos	Hospital de Amor de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-877t2w	<NULL>	Female gender; Ductal Carcinoma in situ or Invasive; Lobular Carcinoma Invasive. Clinical stages 0; I; II or III (annex 2). Karnofsky performance scale (KPS) greater than or equal to 70% (annex 3). Age 18 years or older. Free and Informed Consent Form (annex 4) signed by the patient consenting to undergo the study. Treatment with adjuvant radiotherapy with a total dose of 6000cGy and without treatment to the lymphatic drainage of the supra clavicular fossa.	Male gender; non-conservative surgery; patient with collagen vascular disease; previous treatment with radiotherapy for the respective breast cancer; previous burn at the tumor site. Patient with mental disability. Patients undergoing chemotherapy (QT), except hormone therapy with tamoxifen, anastrozole or letrozole and monoclonal antibody with trastuzumab.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-4hqvqr	The effect of two types of restorations on deciduous teeth in babies	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3592	Effectiveness of restorations in resin-modified glass ionomer cement and bulk-fill resin in deciduous molars of babies: randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4hqvqr	<NULL>	Children physically classified according to the American Society of Anesthesiology (ASA) at level I (healthy); who are undergoing treatment or waiting list for care in pediatric dentistry clinics from FAO-UFMG; Between 18 up to 36 months of age; who present at least two cavitated caries lesions restricted to the occlusal face in radiographically detectable primary molars in dentin, characterized as medium and deep lesions (SCHWENDICKE et al., 2016) being one lesion in each left and right); Only children whose parents/guardians sign the consent form.	Children with deep caries lesions affecting the pulp chamber or at risk of exposure; who have fistula or abscess; pulp exposure; history of spontaneous pain or tooth mobility associated with decayed teeth; molar teeth with other restorations, enamel defects, or endodontic treatment that have carious lesions associated with an existing restoration or that do not stabilize the clamp for absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9xqcws	Traditional resistance training with no load on strength gains, hypertrophy and functionality	Data analysis completed	Intervention	2019-09-28	<NULL>	<NULL>	3593	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9xqcws	<NULL>	The inclusion criterion was to be admitted to the ICU sector of two reference hospitals in Belém, from September to October 2017, to be admitted to the rehabilitation process in the Hospital wards, with a medical certificate allowing the accomplishment of kinesiotherapy	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-72wbbg	Longterm follow-up of patients treated with Lenti-D for an inherited brain disorder	Recruiting	Observational	2020-03-10	<NULL>	<NULL>	3594	Longterm follow-up of subjects with cerebral Adrenoleukodystrophy who were treated with Lenti-D drug product	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-22	Blanchard y Asociados	HCFMUSP – Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72wbbg	<NULL>	Provision of written informed consent for this study by the subject or subject’s parent(s)/legal guardian(s) and written informed assent by subject, if applicable. Have received Lenti-D Drug Product in a parent clinical study. Able to comply with study requirements	There are no exclusion criteria for this Study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-3f9k4r	Blood pressure response in amputee individuals with high blood pressure after aquatic aerobic exercise	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3595	Acute blood pressure response in hypertensive individuals with amputation after aquatic aerobic exercise: a crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-02	Associação de Assistência à Criança Deficiente	Hospital e Centro de Reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-3f9k4r	<NULL>	Individuals with a unilateral transfemoral amputation, who were male (women not included to avoid possible hormonal interference), aged between 40 and 65 years, with a medical diagnosis of systemic arterial hypertension (SAH) controlled with medication, with systolic blood pressure (SBP) ?160 mmHg and diastolic blood pressure (DBP) ? 100 mmHg at rest at the time of assessment; and already adapted to the water environment (so that a possible anxiety or fear of being in the pool could be avoided) will be included.	Individuals with a body mass index (BMI) corrected for amputees greater than or equal to 30 kg/m², with decompensated diabetes mellitus (DM) according to a previous medical assessment, with a history of a cardiovascular event (acute myocardial infarction, stroke) in the last three months, who were smokers, with renal failure, and had orthopedic problems or any physical or mental impairment that would hinder physical exercise will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-33yhw9	Postoperative pain in patients after root canals treatment using 8.25% sodium hypochlorite as irrigating solution	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3596	Postoperative sensitivity in patients after endodontic treatment using 8.25% sodium hypochlorite as irrigating solution of root canals	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-02-10	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-33yhw9	<NULL>	Patients aged 18 to 75 years old; Indicative of endodontic treatment; biopulpectomy or necropulpectomy; Normal health conditions; Signed informed consent term.	Retreatment Immunocompromised patients (who make use of corticosteroids); Any known infectious diseases (e.g., HIV, hepatitis B, hepatitis C, tuberculosis); History of cancer within the oral-maxillofacial region; History of cancer in the last two years; History of radiotherapy of head and/or neck; non-odontogenic facial pain or patients with chronic pain; periodontal compromised tooth with mobility grade 2 or with a 6 mm periodontal pouch depth; teeth with incomplete rhizgenesis; Two adjacent teeth in direct contact subjected to root canal therapy; teeth with alterations that determine an increase in the preparation time (e.g., extreme morphologic changes or complications such as perforations, fractures and root calcifications ; Patients with allergy to Sodio Hypochlorite.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-2q8255	"Effects of whole body vibration on urine loss, quality of life and functioning of women with 
loss of urine: a double-blind randomized clinical trials"	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3597	Effects of whole body vibration on urine loss, quality of life and functioning of women with urinary incontinence: a double-blind randomized clinical trials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2q8255	<NULL>	women with stress urinary incontinence and who are not undergoing any other physiotherapeutic treatment for urinary loss at the time of the research.	Patients with pacemakers or cardiac implants; metallic grafts; acute urinary tract infection; epilepsy, decompensated hypertension, BMI above 40 kg / m2; with a physical disability that unable to receive the intervention or the assessment tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9wskdv	Power resistance training versus traditional on muscle adaptations and functionality in elderly woman	Data analysis completed	Intervention	2020-03-10	<NULL>	<NULL>	3598	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9wskdv	<NULL>	The inclusion criteria were to be at least 60 years old; do not have any acute or chronic condition that would compromise the execution of tests and protocols, have a medical certificate and have not performed RT for at least 1 year before the study	Death or not completing the intervention protocol or withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-226f6j	Clinical and microbiological evaluation after treatment at the site of chronic periodontal disease, with gels containing antimicrobial agents	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3599	Clinical outcomes and microbiological evaluation after in situ treatment of chronic periodontal disease, using antimicrobial-loaded polymeric bioadhesive systems	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-15	Faculdade De Odontologia de Ribeirão Preto	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-226f6j	<NULL>	Patients with chronic periodontitis, with clinical insertion level equal to or greater than 6mm in two or more teeth and probing depth equal to or greater than 5mm in one or more periodontal sites (MACHTEI et al., 1992); Age range from 30 to 75 years old; Not having used antibiotics for at least 3 months; No history of allergy to the components present in the formulations to be tested (MDZ and Tetracyclines).	Severe cardiovascular disease; Pharmacokinetic problems such as nephropathy, liver disease, etc. Patients with a history of tetracycline allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-4zqcyr	How dance can improve the way of walking normally and walking while talking in the elderly	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3600	Effects of a dance intervention on single and dual-task gait in community-dwelling older adults: a randomized controlled blinded trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Fundação de Ensino a Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-4zqcyr	<NULL>	Volunteers aged 60 or over, of both sexes, independent and autonomous, who live in the community, and who do not have metabolic, cardiovascular or musculoskeletal disease that contraindicates physical activity, or even any neurological disease. In addition, the elderly should be able to walk without assistive devices.	Those who initiate or cease physical activity in relation to their baseline activities during the research will be excluded from the study. Individuals with less than 75% attendance in dance sessions will also be excluded, that is, those who have 6 absences or more. Blood pressure greater than 160 / 90mmHg during dance sessions will also correspond to exclusion criteria from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9wt2wj	Evaluation of factors that worsen survival in metastatic patients of skin carcinoma	Recruitment completed	Observational	2020-03-11	<NULL>	<NULL>	3601	Squamous cell carcinoma of the skin with metastases to the parotid gland: factors predictions and survival in a single institution	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Giulianno Molina de Melo	Universidade Federal de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9wt2wj	<NULL>	All patients with squamous cell carcinoma of the skin; with or without organ transplantation; submitted to surgical treatment in the mentioned  period; with the obtaining of anatomopathological reports; clinical follow-up in the Database of surgeries performed in the Head and Neck Discipline	All patients who lost follow-up; with minimum follow-up of three months; those with incomplete medical records; who were not operated on at the institution; who had distant metastases in the first presentation; who had no indication for surgery for other reasons; who had previous irradiation in the head area and neck; those which contained non-squamous cell carcinoma skin tumors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-2vgq7y	Early pulmonary rehabilitation with elastic bands in patients with Exacerbated Chronic Obstructive Pulmonary Disease: Focus on cardiovascular health - vascular function	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3602	Early pulmonary rehabilitation with elastic bands in patients with Exacerbated Chronic Obstructive Pulmonary Disease: Focus on cardiovascular health - Cardiac arterial and autonomic function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2vgq7y	<NULL>	Clinical diagnosis of COPD who present exacerbation of the disease according to GOLD (contacted at least 24 hours and at most 48 hours after the start of standard therapy for exacerbation of COPD); spontaneous breathing at the time of the assessment, in conditions to maintain dialogue; those who agree to participate in the research in a free and informed manner.	Drug users who cause chemical dependency; patients with neurological and orthopedic changes; patients using invasive mechanical ventilation; hemodynamic instability; presence of unstable angina; hx of myocardial infarction in the last six months; other lung diseases; patients over the age of 85 years; and those who do not obtain a diagnosis of COPD after pulmonary function assessment, with ratio values ??(forced expired volume in the first second / forced vital capacity) greater than 0.7 and forced expired volume in the first second greater than 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8dtkq9	Effects of Grape Seed Flour consumption on intestinal flora and metabolic parameters of  individuals with Obesity	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3603	Effects of Grape Seed Flour intake on intestinal microbiota and metabolic parameters in  individuals with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Luciana Pellegrini Pisani	Yasmin Alaby Martins Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-8dtkq9	<NULL>	Male and female adults; between 20 and 59 years old; residents from Baixada Santista; with obesity, BMI between 30 and 39.9 kg/m²	Regular or continuous use of anti-inflammatory or antibiotic medications in the last 3 months; chronic alcohol intake above 30grams per day; heart disease; liver disease; kidney disease; cancer; acute gastrointestinal problems, including diagnosed lactose intolerance; pregnancy or lactation; and menopause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8p9fmn	Management of Gingival Smile using Botulinum Toxin	Data analysis completed	Intervention	2020-03-11	<NULL>	<NULL>	3604	Management of Gingival Smile using Botulinum Toxin Type A: pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8p9fmn	<NULL>	Patients aged between 18 and 40 years, who presented gingival exposure when smiling, greater than or equal to 3 mm, bilaterally.	patients with systemic impairment, a history of hypersensitivity to the toxin, immunodeficiencies or who had applied the toxin less than six months ago; patients who received treatment with aminoglycosides, anticholinergic drugs or other agents that could interfere with neuromuscular transmissions or muscle relaxants (as the effect of botulinum toxin can be enhanced); patients with neuropathic diseases of the peripheral system, sclerosis or any disorders of the neuromuscular junction due to the increased risk of clinically significant adverse reactions; patients with infection at the application site, psychologically unstable or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8kgqk4	Effect of a muscle strengthening of the 1st dorsal interosseous in subjects with rhizarthrosis: a randomized controlled trial.	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3605	Effect of a treatment protocol focusing on Muscle Strengthening of the 1st dorsal interosseous on aspects of activity and participation in subjects with Rhizarthrosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8kgqk4	<NULL>	Volunteers with a medical diagnosis of rhizarthrosis; without cognitive impairment, taking into account a normal score on the Mini-Mental State Examination for the respective level of education.	Uncontrolled diabetes; neurological and/or musculoskeletal disorders that may affect upper limb function; fracture or previous surgical intervention on the wrist or fingers; the presence of any other rheumatologic disease; TMC joint infiltration within the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-7pgcyq	Impact of diode laser in treatment of oral white lesions and proetins in the saliva related to recurrence and malignant transformation	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3606	Impact of diode laser in the treatment of oral leukoplakia and proteomic profile related to recurrence and malignant transformation a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-7pgcyq	<NULL>	Patients diagnosed with oral leukoplakia (through biopsy, performed and histologically analyzed at the Oral Pathology Service of the Piracicaba Dental School); epithelial dysplasia confirmed according to criteria established by the World Health Organization (WHO) by two experienced pathologists from the service; oral leukoplakia located in the region of the lateral border of the tongue, floor, retromolar region or soft palate	Will be excluded fron the study: patients with oral leukoplakia without epithelial dysplasia; with oral leukoplakia located in other regions that are not mentioned in the inclusion criteria; patients with a biopsy realized in other services than the Piracicaba dental School; with a history of previous oral carcinomas; chemotherapy or radiotherapy in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9m72x9	TheraTogs garments on trunk balance in child with Cerebral Palsy	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3607	Effect of TheraTogs garments on postural control in individuals with Cerebral Palsy.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Estadual de Campinas - Unicamp	Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-9m72x9	<NULL>	Children with Cerebral Palsy; aged 2 to 15 years; with unstable trunk control; classified with GMFCS as levels III, IV and V	Children who present stable trunk control at the initial assessment, without using TheraTogs garments; children who do not collaborate with the clinical test using the SATCo scale to assess trunk control; children who do not agree to put on and / or remain with the TheraTogs orthotic garments for 50 minutes; children who have allergies or any type of reaction to contact with the material of the garment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9wgwnj	The influence of genetic variations on Migraine	Recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3608	The influence of dopamine-related genetic polymorphisms on susceptibility and behavior of Migraine	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-31	Hospital de Clinicas da Universidade Federal do Paraná.	Hospital de Clinicas da Universidade Federal do Paraná.	https://ensaiosclinicos.gov.br/rg/RBR-9wgwnj	<NULL>	Will be included individuals who meet the diagnostic criteria for migraine without aura, migraine with aura and / or chronic migraine associated or not with abuse of analgesics; are between 18 and 65 years of age at the time of inclusion; accept to participate in the study on a voluntary basis. The control group will include people who do not suffer from headache and for that, they should answer negatively to the question: &quot;Have you ever suffered from frequent headaches and without an obvious cause?&quot;. Patients with complaints other than headache will be invited, employees of recruiting institutions, escorts of patients with no familiarity with the study group, volunteers recruited from disclosure by verbal approach or physical media and electronic.	Will be excluded from the study individuals who do not complete all applied scales; present other types of headache concomitantly, such as trigeminal neuralgia and secondary headaches; withdraw the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-6dq7tz	Effects of crustacean oil supplementation on lipid profile and inflammatory markers in overweight women	Recruitment completed	Intervention	2020-03-11	<NULL>	<NULL>	3609	Effects of supplementation with Krill Oil on lipid profile and inflammatory markers in women with overweight	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-10-25	Gustavo Duarte Pimentel	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6dq7tz	<NULL>	Adult women, aged 20 to 59 years and BMI &gt;25 kg / m2.	Elderly and adult women diagnosed with: kidney disease; cardiovascular; hepatic; cancer; pregnant women; lactating; chronic drinkers; using anti-inflammatory drugs or affecting appetite or body weight; in an inflammatory or infectious process on the day of collection or in the previous seven days; who participated in any food restriction program or following a specific diet, using dietary supplements in the last six months and intolerant or allergic to seafood in general.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-76qyq8	Postoperative follow-up of 5 years of surgical treatment for urinary loss of effort	Not yet recruiting	Observational	2020-03-11	<NULL>	<NULL>	3610	Clinical study between Mini-slings and Transobturator sling for the treatment of Stress urinary incontinence: a 5 year follow up	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Centro Universitário Saúde ABC - FMABC	Centro Universitário Saúde ABC - FMABC	https://ensaiosclinicos.gov.br/rg/RBR-76qyq8	<NULL>	Patients over the age of 18 years; absence of associated neurological diseases; patients previously submitted to surgical treatment to correct urinary incontinence, either by transobturing sling or mini-sling; patients who accept to attend and undergo the proposed procedures.	Pregnancy; acute urinary infection; sequelae of high exposure to ionizing radiation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-6p8zfs	Study of quality of life after Sialendoscopy	Recruitment completed	Observational	2020-03-11	<NULL>	<NULL>	3611	Quality of life and clinical outcomes after Sialendoscopy for obstructive salivary gland diseases treatment: a tertiary center study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-05	Giulianno Molina de Melo	Real e Benemérita Associação Portuguesa de Beneficência/SP	https://ensaiosclinicos.gov.br/rg/RBR-6p8zfs	<NULL>	All patients who had undergone to sialendoscopy; with or not to combined open cervical preservative gland access; due to obstructive salivary gland disease	Cases of missing records; abandonment of treatment prior to completion of the planned sialendoscopy; submitted to open surgical treatment with salivary gland resection with or without sialendoscopy; patients who missed the follow-up; patients who refused to participate in the study; patients previously submitted to other surgical procedure on that particular  salivary gland;  submitted to previous radiotherapy for another head and neck neoplasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-7qnxty	Effect of Self Massage on muscle strength in female soccer athletes	Data analysis completed	Intervention	2020-03-12	<NULL>	<NULL>	3612	Effect of Self-Myofascial Release on muscle strength in female soccer athletes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Samuel Miranda Souza	Universidade Católica do Salvador	https://ensaiosclinicos.gov.br/rg/RBR-7qnxty	<NULL>	Being a female soccer athlete at Esporte Clube Vitória	Athletes who were in the process of recovering from lower limb injuries; athletes who underwent surgery in the last eight months prior to the collection period; athletes who presented some condition that would make them unable to perform the practices.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7qj2tf	Traditional resistance training and use of blood flow restriction in muscle hypertrophy and functionality gains	Data analysis completed	Intervention	2020-03-13	<NULL>	<NULL>	3613	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7qj2tf	<NULL>	The inclusion criterion was to be admitted to the rehabilitation process in the hospital wards, with a medical certificate allowing the performance of kinesiotherapy in two reference hospitals in 2017. As well as been at least 50 years old	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-42nd7q	Medical Record Model Oriented to problems with the use of medications in patients with Heart Failure admitted to the Intensive Care Unit	Data analysis completed	Intervention	2020-03-13	<NULL>	<NULL>	3614	Medical Record Model Oriented to Pharmacotherapeutic Problems of Patients with Heart Failure Admitted to the Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-42nd7q	<NULL>	Patients will be included: over 18 years old; who have not been transferred from the ICU to other hospitals; with an APACHE II score 20; with no current cancer diagnosis; absence of surgery in the last six months; and, who presented at least one PRM identified by the research pharmacists through the DAM medical record	We will exclude patients: with data collection beginning after the first 48 hours of hospitalization; with hospital stay less than 72 hours; who are admitted for palliative care; higher probability of early death (defined as death occurring between the 48th and 72nd hours of ICU admission); diagnosed with suspected or confirmed brain death; aware that they refuse to participate in either group after randomization; who refuse to participate in the study after recovering an adequate state of consciousness for decision-making, when their entry is made by the authorization of family members and / or guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7q7cq8	Sensitivity after composite resin restorations with previous desensitizing application	Recruitment completed	Intervention	2020-03-16	<NULL>	<NULL>	3615	Postoperative sensitivity in composite resin restorations with prior desensitizing agent application: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-07	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-7q7cq8	<NULL>	"Volunteers over 18 years old; presence of 4 class I (occlusal) or class II cavities in the molar or premolar teeth; cavities with medium or deep depth (up to 3 mm) resulting from primary caries or need for restoration replacement; teeth with pulp vitality;
Enamel gingival margin in class II preparations; absence of non-carious cervical lesions in the teeth involved in the research;
occlusal contact with an antagonist tooth and at least one contact with an adjacent tooth;
Patient with good general health; do not have any contraindications for dental treatments."	"Present less than 20 teeth; history of spontaneous dentinal sensitivity; periodontal disease; bruxism; teeth with impossibility of absolute isolation; teeth with pulp exposure during cavity preparation; teeth that needed pulp protection in addition to the application of the adhesive system during the restorative procedure; allergy to resinous materials; impossibility to return to reevaluation consultations; fractured or visibly cracked tooth; conducting current desensitization therapy, including desensitizing toothpastes or other desensitizing products; medical, psychiatric or pharmacotherapeutic history that may compromise the protocol, including the chronic use of anti-inflammatory, analgesic and psychotropic drugs; pregnancy or breast-feeding; allergies and idiosyncratic responses to the composition of the products;
orthodontic treatment performed within the previous three months; abutment teeth for fixed or removable prosthesis; teeth or support structures with any painful pathology;
periodontal surgery within the previous three months; patients under whitening treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-6ng4my	Maneuver of shoulder movement for central catheter advance in newborn	Recruiting	Intervention	2020-03-16	<NULL>	<NULL>	3616	Maneuver of Shoulder Elevation, Protraction and Lowering for Progression of Peripherally Inserted Central Catheter in Newborn: Experimental Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-07	Universidade Federal do Ceará	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-6ng4my	<NULL>	"Newborn with indication of Peripherally Inserted Central Catheter insertion; at any gestational age and birth weight; without any congenital malformation of the upper limbs; no suspicion or confirmation of fracture and / or dislocation of the upper limbs and / or collarbone, detected by physical examination, performed by the researchers involved or assisting nurse, or through notes in the medical records by the evaluation of the attending physician.
A newborn with at least one of the veins, right or left basilica or right or left cephalic veins, free of bruising and / or any lesions in the path of the right and left basilic and cephalic veins above the left puncture site; hemodynamically stable newborn, ie, with normal cardiac and saturation parameters and no oscillations. These data will be extracted from the records of each newborn and / or through the evaluation of nurses who are part of the data collection."	The exclusion criteria will be when the chest radiography is performed after three hours of cateter insertion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-4yq8n9	Evaluation of the use of medications in wisdom tooth extraction surgeries	Data analysis completed	Intervention	2020-03-16	<NULL>	<NULL>	3617	Drug evaluation in third molar surgeries. Blind, randomized clinical trial in divided mouth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Instituto de Ciência e Tecnologia - Câmpus de São José dos Campos	Instituto de Ciência e Tecnologia - Câmpus de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-4yq8n9	<NULL>	Patients in need of extraction of third molars, regardless of gender; presence of teeth in opposite hemiarchs with similar positions; patients aged between 15 and 40 years; patients who voluntarily agree to participate in the research, being aware of the risks and benefits, and signing the Informed Consent Form (ICF).	Patients with local or systemic changes that contraindicate the procedure; use of anti-inflammatory drugs in the last 15 days; presence of lower third molars in different position and classification of inclusion on both sides; erupted lower third molars; patients allergic to amoxicillin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-38x665	Analysis of biological blood markers after computer-based memory stimulation in adults over 45 years old attended at the memory clinic	Data analysis completed	Intervention	2020-03-16	<NULL>	<NULL>	3618	Analysis of serums neurobiomarkers  after cognitive stimulation using technology in adults over 45 years old at the Memory Clinic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-38x665	<NULL>	Adults and elderly aged between 45 and 80 years old; assisted by the Unified Health System at the Memory Clinic at the UNISUL; Cognitive assessment performed by MoCA with a score above 12.	Individuals with dementia or with visual impairment or physical/mental condition that disallow to move at the University and attending an intervention using a desktop computer with internet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-5539cm	Randomized trial using amitriptyline medication to prevent neuropathic pain in patients who have leprosy neuritis.	Not yet recruiting	Intervention	2020-03-16	<NULL>	<NULL>	3619	Randomized clinical trial of the use of amitriptyline for the prevention of neuropathic pain in patients with leprosy neuritis	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2020-03-30	Fundação Oswaldo Cruz	Instituto Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-5539cm	<NULL>	The study will include patients older than 18 years; with a clinical diagnosis of neuritis; confirmed by electroneuromyography; registered at the service and diagnosed with neuritis; from February 2020 to January 2022.	Patients diagnosed with neuropathic pain;Patients with known contraindications to the use of amitriptyline: ischemic heart,disease, cardiac arrhythmia, glaucoma and / or history of urinary retention in men;Patients with concomitant leprous nodular; erythema being treated with thalidomide;Patient with previous use ofamitriptyline and  or neuropathic pain;Patient with cognitive impairment;Pregnancy or breastfeeding;Prophylactic use of amitriptyline in a previous episode of neuritis, that is, the patient will only be included once	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-5gs5w6	Fall in core temperature and rewarming in severe infections	Recruiting	Intervention	2020-03-17	<NULL>	<NULL>	3620	Spontaneous hypothermia and rewarming in sepsis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-18	Instituto de Ciencias Biomedicas -- Universidade de Sao Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5gs5w6	<NULL>	Septic patients (Sepsis-3) with core temperature of less than or equal to 35.5ºC. Both sexes; age between 18 and 120 years.	Patients with extensive burns (greater than 30% of body surface area), metastatic cancer, brain tumor, brain trauma, spinal cord injury, pregnancy. Patients subjected to active cooling within 24 h of the sepsis diagnosis will also be excluded, as will patients subjected to surgery within 24 h of the onset of hypothermia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-37ymzb	Guided imagery relaxation to improve quality of life of patients undergoing bone marrow transplantation	Recruiting	Intervention	2020-03-17	<NULL>	<NULL>	3621	Guided imagery relaxation to improve quality of life of patients undergoing hematopoietic stem cell transplantation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Programa de Pós-Graduação em Enfermagem da Universidade Federal do Paraná	Programa de Pós-Graduação em Enfermagem da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-37ymzb	<NULL>	Patients who will undergo hematopoietic stem cell transplantation; aged over 18 years; both genders.	Patients who are physically unable to complete questionnaires, see, hear; have a history or are being treated for vertigo, labyrinthitis and / or epilepsy recorded in the medical record.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-23jx2s	Low doses of Midazolam to reduce Anxiety in Pregnant Women undergoing Cesarean Section	Data analysis completed	Intervention	2020-03-17	<NULL>	<NULL>	3622	Low doses of Midazolam to produce Anxiolysis in Pregnant Women undergoing Cesarean Section	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-06	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-23jx2s	<NULL>	Pregnant women indicated for cesarean section; aged between 18 And 40 years; physical status ASA II by the American Society of Anesthesiologists	Restriction of fetal development, fetal malformations, acute fetal distress, multiple pregnancy, acute pain, moderate to severe pneumopathies, psychopathologies that interfere with autonomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-87ndrv	The effect of concurrent training and a herbal medicine on menopausal women.	Recruiting	Intervention	2020-03-17	<NULL>	<NULL>	3623	The effect of concurrent training and vitex agnus-castus on menopausal women in psychological, physical aspects, hormonal profile and sexual function: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-15	Univerdade do Estado de Santa Catarina	Univerdade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-87ndrv	<NULL>	Only menopausal women who fit the menopause rating scale and follicle stimulating hormone levels above 25 IU will be included; who have not practiced concurrent training in the three months prior to data collection and who refrain from practicing physical exercises other than intervention during this period.	Women who do not experience menopausal symptoms according to the menopause rating scale and follicle stimulating hormone levels above 25 IUml; those who do not abstain from training during the intervention period; as well as those with a history of neurological and or musculoskeletal diseases; and who have performed aerobic or endurance training in the three months prior to data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-2f8mtn	Ingestion of Cannabis oil in Fibromyalgic people	Data analysis completed	Intervention	2020-03-17	<NULL>	<NULL>	3624	Cannabis oil in Fibromyalgic people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-27	Escola de Saúde Pública de Florianópolis	Escola de Saúde Pública de Florianópolis	https://ensaiosclinicos.gov.br/rg/RBR-2f8mtn	<NULL>	Fibromyalgia diagnosis (ACR 2010 criteria); age over 18 years; ability to sign the informed consent form; presence of moderate to severe symptoms despite therapies in use; at least one medical or nursing consultation at Health Center on the last year.	Decompensated organic comorbidities and/or risk psychiatric conditions (schizophrenia, psychosis, severe personality disorder, current suicidal ideation); other well defined cause of chronic pain; current pregnancy/lactation; moderate or severe cognitive impairment; history of cannabinoids sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-3g6q92	Use of copaiba oil-based emulsion in the teeth restoration process	Not yet recruiting	Intervention	2020-03-18	<NULL>	<NULL>	3625	Clinical Trial of Copaifera multijulga Hayne oil-based Emulsion as a biomodifier of dentin adhesion	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3g6q92	<NULL>	The participant must present deciduous molar teeth with up to 1/3 of root resorption affected by a shallow or medium occlusive-proximal caries lesion with surrounding enamel throughout; do not present dental malformation and spontaneous pain in the teeth. Do not have systemic disease, such as diabetes, hypertension and heart disease.	Patients will be excluded if there is a fistula or edema in the intra or extra-oral region, radiolucency in the furcation region of the tooth, or if the successor tooth of the deciduous tooth is missing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-6kg36j	The role of yogic breathing techniques on cognition and emotions of university students	Recruiting	Intervention	2020-03-16	<NULL>	<NULL>	3626	Breathing techniques of yoga on self-regulation of learning and emotions in university students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6kg36j	<NULL>	The following will be included: Healthy university students of both sexes (undergraduate and graduate students) from UFRN between 18 and 30 years old who sign the informed consent form (ICF) as research volunteers.	The following will be excluded: People who report having psychiatric disorders or make use of psychotropic drugs; Who report having restrictive or obstructive breathing problems, smoking, asthma and / or recurrent allergic rhinitis, significant deviated septum; Who have regularly practiced any type of meditation throughout their lives (Yoga, Tai Chi, Mindfulness, etc.); Any volunteer who practices less than 4 times a week over the three months of intervention (ideally 7 times a week or daily).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-54ngrx	The influence of physical activity for patients with liver cirrhosis	Data analysis completed	Intervention	2020-03-18	<NULL>	<NULL>	3627	Effect of physical exercise in cirrhotic patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-54ngrx	<NULL>	Age over 18 years; Carrier of liver cirrhosis.	Smoking; coronary disease; presence of hepatocellular carcinoma; use of vasoactive drugs (except propranolol); use of current interferon or in the last 3 months; use of corticosteroids; duration of the infectious condition; upper gastrointestinal bleeding in the last two weeks; pregnant; musculoskeletal injuries; upper digestive endoscopy with medium or large caliber esophageal varices without eradication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-46tjy3	Effects of nicotine on the vision and cognition of nonsmokers	Recruiting	Intervention	2020-03-18	<NULL>	<NULL>	3628	Effects of nicotine gum on early-stage visual processing and cognition in healthy nonsmokers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-16	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-46tjy3	<NULL>	Participants who do not use alcohol (only moderate use ~ 5 weekly doses will be recruited; do not use of psychotropic drugs; do not have Axis I or II disorders (measured by the Mini International Neuropsychiatric Interview ~ MINI). All participants will respond to Fagerstrom Test of Nicotine Dependence (FTND), which measures whether they have nicotine dependence. Demographics will be collected by one of the responsible researchers through a brief anamnesis.	All participants who use alcohol or psychostimulant drugs, known autoimmune disease or AIDS, ophthalmic disorders such as glaucoma or retinopathies will be excluded from the study. In addition, participants who present any neuropsychiatric disorder or disease that affects visual functions will be excluded from the sample. Participants with a family history or presence of depression or anxiety will be screened for further studies. In addition, the presence of additional medications (therapeutic dose or not) will serve as an exclusion criterion since these participants will be part of an additional group, not measured in this work. All participants who for any reason no longer wish to participate in the research will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-2zpcvy	Evaluation of the effect of Oxygen Gel on Wound Healing of patients admitted to an intensive care unit	Recruiting	Intervention	2020-03-18	<NULL>	<NULL>	3629	Evaluation of the effect of Active Oxygen gel on the healing of Pressure Injuries, grades II and III, of patients admitted to ICUs of the worker hospital complex	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-28	Universidade Positivo	Hospital do Trabalhador	https://ensaiosclinicos.gov.br/rg/RBR-2zpcvy	<NULL>	Patients with grade two or three ulcers; age over 18 years; both genders; admitted to the intensive care unit.	Sensitivity to any component of the product formula; lesions progressing to grade four or grade one pressure ulcer lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7x65zj	Effects of full body Light Therapy on the muscular performance of Rugby athletes: randomized, double-blind, crossover and placebo-controlled clinical trial	Suspended	Intervention	2020-03-19	<NULL>	<NULL>	3630	Effects of full-body Photobiomodulation on muscle performance in Rugby athletes: randomized, double-blind, crossover and placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-17	Universidade Federal de São Carlos	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7x65zj	<NULL>	Healthy volunteers; male gender, non-smokers, age between 18 and 30 years, body mass index (BMI) between 18 and 30 kg / m2; volunteers must be rugby athletes for at least 1 year	Rugby athletes who have orthopedic lesions in the lower limbs previously (2 months) or during the development of the study; athletes making regular use of pharmacological agents and / or ergogenic supplements; athletes who regularly use alcohol and / or tobacco; athletes with cutaneous lesions (open wounds) on the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-6pqx4n	Efficacy of Duloxetine in Chronic facial pain	Recruitment completed	Intervention	2018-09-03	<NULL>	<NULL>	3631	Efficacy of Duloxetine in Chronic temporomandibular disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Faculdade de Odontologia de Bauru	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pqx4n	<NULL>	age greater than 18 years, diagnosis of painful TMD, for example, masticatory myalgia, arthralgia of the temporomandibular joint and headache attributed to TMD diagnosed according to Diagnostic Criteria for Temporomandibular Disorder; presence of pain for at least 3 months	presence of uncontrolled systemic disorders, for example, diabetes, hypertension or endocrine disorders; presence of epilepsy, renal, hepatic and cardiac disorders; presence of neuropathies; pregnancy or lactation; intolerance to duloxetine or any component of the formulation; treatment for TMD in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-685dmr	"Efficacy of Selegiline Chloridate in the treatment of changes
Nervous due to Surgery for Corrections in the Maxilla and Mandible"	Recruiting	Intervention	2020-03-19	<NULL>	<NULL>	3632	Efficiency of Selegiline Chloridate in treating Neurosensory Disturbances Arising from Orthognic Surgery	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-09-02	Universidade de Pernambuco	comissão de aperfeiçoamento de pessoal de nível superior	https://ensaiosclinicos.gov.br/rg/RBR-685dmr	<NULL>	Patients of both sexes aged between 18 and 40 years; patients undergoing bimaxillary orthognathic surgery to correct class II dentofacial deformity with mandibular advancement not exceeding 7 mm; those who do not have third molars (18,28, 38 and 48) or who have been completely removed at least six months before surgery. Those who agree with the research and sign the free and informed consent form; patients who report not having sensorineural disorders before surgery; not having autoimmune syndromes or diseases; patients who do not have pre-diagnosed psychiatric or psychological disorders; patients who do not have heart disease, liver disease, rheumatological, diabetic or chronic kidney problems; not having basic diseases that alter the patient&apos;s sensory perceptions; those who do not have the presence of wounds or dermatological pathologies on the face, which may impair the application of the tests proposed in this study; patients who do not use controlled medication or who, through drug interaction, contraindicate the use of any of the therapies proposed in this study; patients who do not have allergies to the drugs of interest in this research; women who are not pregnant or breastfeeding.	Those who do not have any sensorineural changes in the postoperative period; Patients who have an unwanted fracture or visible rupture of the lower alveolar nerve during the operation; patients who, during the operation, present abnormal bleeding or are at risk of developing pseudoaneurysms; those that, during the operation, it is necessary to fix the segments only with bicortical screws or in a hybrid form (plate and monocortical screws plus bicortical screw); patients who, at the operator&apos;s option, need maxillomandibular block in the postoperative period; individuals who have developed any postoperative infection at the surgery site; patients who develop any allergies or unwanted effects related to selegiline hydrochloride; participants who experience episodes of vomiting or any discomfort that has not been remedied with protective medication; those who happen to present some alteration in the hemodynamic, hepatic and / or renal parameters, which will be evaluated periodically during the research through laboratory tests of control; participants who, for whatever reason, spontaneously wish to give up participating in the research; those who do not comply or who do not attend all stages of the research; women who are pregnant or breastfeeding during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-5psg4w	Study of the Effectiveness of Oral Solutions for Intestinal Cleansing Before Colonoscopy	Recruitment completed	Intervention	2020-03-19	<NULL>	<NULL>	3633	Analysis of Efficacy and Tolerance of Oral Solutions for Colonoscopy Preparation in patients referred to service in the state of Bahia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-5psg4w	<NULL>	Patients older than 18 years; signature of the TCLE; colonoscopy indication	Patients with a history of coronary syndrome; heart, kidney or liver failure; intestinal obstruction or semi-obstruction; previous colectomy; hydroelectrolytic disorders; INR&gt; 2.5 and / or Platelets &lt;40,000	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-45kmbp	Effects Of Continuous Current In Shadows And Quality Of Life In Women With Primary Hyperidrosis	Not yet recruiting	Intervention	2020-03-19	<NULL>	<NULL>	3634	Direct current aApplication in the treatment of hyperhidrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-45kmbp	<NULL>	Female volunteers, aged 18 to 300years old, who had primary hyperhidrosis without ever having received previous treatment for this chronic disease (treatment).	Male patients, patients with sensitivity to electric current, patients with dermatological damage, heart problems, pregnant women, diabetics or those with uncontrolled hypertension, as well as those with neoplasms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7mty35	Implementation Intention to reduce salt intake on Heart Failure	Data analysis completed	Intervention	2020-03-20	<NULL>	<NULL>	3635	Implementation Intention strategies to reduce sodium intake among Heart Failure patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-12	Faculdade de Enfermagem, Universidade Estadual de Campinas	Faculdade de Enfermagem, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7mty35	<NULL>	"There were included Heart Failure patients and their social referee.
For patiets the inclusion criteria were: Age over 18 years old and inferior to 85 years old; Being in clinical follow-up for at least 6 months.
For social referee: Wife/ husbund, daughters/ sons, parents, house workers or any other person who was reponsible to prepare the patients meal at home; Age over 18 years old and inferior to 85 years old; Available to go with patient to the health clinic in all phases of the study."	"Patients were excluded: With diagnosis of Hert Failure functional class IV; With recently history of being hospitalized (less than 01 month) before the study; With no condition of effective verbal communication; With diagnosis of mental disorders (described in medical report); Whose social referee who prepares meals at home could not be present at all consultations. 
For socials referee: With no condition of effective verbal communication; Wiht diagnosis of mental disorders (described in medical report); Who did not agree in participating of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-6dj5y4	The impact of mouth radiotherapy dose distribution on the occurrence and severity of radiotherapy-induced oral mucositis	Recruiting	Observational	2020-03-20	<NULL>	<NULL>	3636	Impact of dosimetric distribution on oral mucosa on the incidence and severity of oral mucositis induced by radiotherapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Instituto do Câncer do Estado de São Paulo	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-6dj5y4	<NULL>	Patients with oral squamous cell carcinomas (C02; C02.1; C04; C05; C10), who concluded a pre-radiotherapy oral compliance protocol with  the ICESP Oncological Dentistry Service. Patients on an oral exclusive diet prior to  radiotherapy and who will use oral stent during radiotherapy sessions. Patients should also be on the Institutional protocol Oncological Dentistry Service, with daily follow-up at the laser therapy clinic (photobiomodulation).	"Will be excluded from our protocol patients with:
- Squamous cell carcinomas in non-oral topographies;
- Interruption of radiotherapy treatment;
- Karnofsky scales below 40%;
- Performing diet via nasogastric tube and gastrostomy before radiotherapy
-Patients edentulous and not candidates for the use of oral stents according to the Institutional protocol;
- Patients with non adherence to the laser therapy protocol, or up to 5 consecutive absences in outpatient laser therapy appoinment follow up."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7g4gp4	Effect, safety and action of Ketotifen associated with Famotidine  in the treatment of facial stains.	Not yet recruiting	Intervention	2020-03-20	<NULL>	<NULL>	3637	Evaluation of the efficacy of using Ketotifen associated with Famotidine in the oral treatment of facial melasma in women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-20	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-7g4gp4	<NULL>	women; aged 18 to 60 years; moderate to severe facial melasma; no treatment for at least 30 days.	dermatoses with photosensitivity; history of hypersensitivity to ketotifen or famotidine; personal history of liver disease; pregnant women; lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-44vc9n	The effects of early parenting on autism spectrum disorder	Recruitment completed	Intervention	2020-03-20	<NULL>	<NULL>	3638	Effectiveness of early parental coaching in autism spectrum disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Paraná	Centro de Neuropediatra do Complexo do Hospital de Clínicas do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-44vc9n	<NULL>	The following inclusion criteria were established: present physical conditions that guarantee an effective degree of collaboration in the evaluations; Age compatible with the purpose of the study, from 29 to 42 months; Presentation of the consent form signed by the parent or guardian; Be male; Parents or guardians were willing to attend parental coaching weekly during the survey; Has no other diagnosis of any impairment (visual, hearing, motor).	Excluded from the study were children who, even after giving and signing the Informed Consent Form: wish to withdraw from participating in the research at any stage for any reason; Not participating in all stages of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4kpbhp	Comparing three drugs for reducing heart rate and blood pressure during laryngoscopy and intubation	Data analysis completed	Intervention	2020-03-20	<NULL>	<NULL>	3639	Comparative study of iv esmolol,iv diltiazem, and iv lignocaine hydrochloride in attenuating pressure response to laryngoscopy and intubation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-12	Government medical college haldwani	Government medical college haldwani	https://ensaiosclinicos.gov.br/rg/RBR-4kpbhp	<NULL>	"Patients equal to or greater than 18 years  and equal or lesser than  60 years of age;Patients weighing equal to or greater than 40kg and equal or lesser than 90 kgs of either sex  and BMI equal to or greater than 18.5  and equal or lesser than 24.9 of either sex;Patients posted for elective Surgical Procedure belonging to ASA physical status – 
Grade I and II;Patients requiring general Anesthesia and Endotracheal Intubation."	Patient / guardian refusal for consent;ASA grade III and IV;Emergency surgeries;Patients between age greater than 60 years and Age lesser than 18 years;Patients weighing greater than 90kg and lesser than 40kg  and BMI lesser than 18.5 and  greater than 24.9;Patients suspected to have difficult tracheal intubation;Patients on beta-blockers or calcium channel blockers;Patients with significant renal (serum creatinine greater than 1.5mg/dl) ,hepatic (serum total bilirubin greater than 1.2 mg/dl, serum total protein lesser than 6g/dl &amp; greater than 8.5g/dl ,serum albumin lesser than 3.5g/dl &amp; greater than 5g/dl , serum SGPT greater than 40u/l , serum SGOT greater than 56u/l) disease;Hypertensive patients systolic blood pressure greater than 160 mmHg and or diastolic blood pressure greater than 95 mmHg;Patients with chronic obstructive lung diseases especially bronchial asthma;Diabetic patients on treatment;Patients with significant heart disease like past history of  angina or myocardial infarction , heart blocks , and congestive cardiac failure;Laryngoscopy and intubation exceeding 20 seconds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-99s7wv	Use of Local Anesthetic during third molar extraction and its effect on the prevention of postoperative pain	Recruitment completed	Intervention	2018-11-19	<NULL>	<NULL>	3640	Evaluation of Ropivacaine effectiveness for Preventive Analgesia on third molars extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-13	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-99s7wv	<NULL>	Patients who sought ambulatory  dental services in the Dentistry Department of Sergipe Federal University (UFS) for bilateral impacted third molars extraction , with ASA I physical status.	Users of illicit or psychotropic drugs, heavy alcohol users and those who reported of hypersensitivity to local anesthetics or non-steroidal anti-inflammatory drugs (NSAIDs) or to any other drug that might interfere with pain sensitivityd. Moreover, pregnant and odontophobic patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-9xpg3j	Clinical and microbiological evaluation of the dental canal	Recruiting	Intervention	2020-03-23	<NULL>	<NULL>	3641	Clinical, microbiological, immunological and biomolecular monitoring of different pulp and periradicular conditions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas	Faculdade de Odontologia de Piraicaba-Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9xpg3j	<NULL>	Patients with systemic health condition ASA I or II. Permanent teeth with pulp necrosis; pulp vitality; pulpitis; endo-perio lesions; endodontic treatment failure; periapical lesion; periodontal tissues.	use of antifungals; antibiotics; immunosuppressants; and antivirals (up to  3 months previously to the study); and teeth with root fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5n4q8b	Clinical study of the influence of surface treatment on dentin before dental restorations near the gingiva	Recruitment completed	Intervention	2020-03-23	<NULL>	<NULL>	3642	Randomized, triple-blind clinical study of the influence of surface treatment on adhesion of noncarious cervical lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-03	Cristiane de Melo Alencar	Cristiane de Melo Alencar	https://ensaiosclinicos.gov.br/rg/RBR-5n4q8b	<NULL>	Acceptable oral hygiene; present at least 20 teeth under occlusion; present at least two non-carious cervical lesions to be restored in two different teeth; non-carious lesions deeper than 1 mm.	Participants with a compromised medical history; periodontal disease; severe or active carious disease; use of orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-3wvgrz	Evaluation of hypersensitivity after composite resin restorations in posterior teeth made by undergraduate students	Recruiting	Observational	2020-03-23	<NULL>	<NULL>	3643	Evaluation of postoperatory hypersensitivity in class I and II composite resin restorations made by undergraduate students	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-10-09	Ana Paula Rodrigues de Magalhães-Chaves	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3wvgrz	<NULL>	Above 18 years-old; both genders; good general health; good oral higiene; received at least one direct composite restoration class I or class II in UNIP&apos;s clinics; at least 20 teeth in the mouth.	Presence of unilateral cross-bite; presence of previous dental hypersensitivity; restoration carried out was considered superficial, or, 0.5-1.0 mm bellow enamel-dentin junction; teeth with all cusps compromised; teeth without pulp vitality or with endodontic treatment; smokers; loss of vertical dimension; parafunctional habits; periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-36vxx7	Skin cancer with spread to the parotid: evaluation of factors that worsen the clinical picture	Recruitment completed	Observational	2020-03-23	<NULL>	<NULL>	3644	Squamous cell carcinoma of the skin with metastases to the parotid gland: prognostic factors and survival in a single institution	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Giulianno Molina de Melo	Universidade Federal de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-36vxx7	<NULL>	all patients with non-melanoma skin cancer  squamous cell carcinoma subtype; squamous cell carcinoma histologic variants; from head and neck region; with parotid metastasis; neck metastasis; submitted to surgical treatment with curative intent; with a minimum follow-up of three months	other histologic subtypes than squamous cell carcinoma; patients who lost follow-up; with incomplete clinical data; submitted to surgery outside institution from their primary or neck; with distant metastasis at first presentation; who refused to participate in the study; who were not submitted to surgery due to advanced clinical status	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5khj37	Evaluation of a new substance (cysteamine 5% cream) compared to the use of hydroquinone 4% cream to treat facial blemishes	Recruitment completed	Intervention	2020-03-23	<NULL>	<NULL>	3645	Cysteamine 5% cream versus hydroquinone 4% cream in the treatment of facial melasma: a clinical parallel trial, controlled and blind assessment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-21	Faculdade de Medicina de Botucatu (FMB - Unesp)	Escola Paulista de Medicina (EPM/UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-5khj37	<NULL>	Women with facial melasma 18 to 50 years old, Fitzpatrick&apos;s phototypes II to V.	Pregnant and lactating women; women with vitiligo or photosensitizing diseases; individuals who are using other whitening substances and those who refuse to be photographed; photoexposed women and menopausal women (after 50 years).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5w6gk2	Cardiovascular physiotherapy in the health care unit	Not yet recruiting	Intervention	2020-03-23	<NULL>	<NULL>	3646	Cardiovascular physiotherapy in primary care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Estadual de Goiás	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5w6gk2	<NULL>	Will be included in the study of sedentary patients of both sexes; without cognitive impairment (mini-mental more than 17);  aged 60 years or over; independent walking and CSF Jardim Dom Fernando II frequenters.	Elderly practitioners of regular physical activity (more than 150 minutes of moderate-intensity physical activity per week), with unstable angina, cardiac resynchronizer, cardiac surgery less than three months, heart failure (NYHA class III,IV), will be excluded. diabetes mellitus (fasting glucose more than 180 mg.dL and or glycated hemoglobin more than 7.0%), chronic renal failure (glomerular filtration less than 50 ml.min.1.73m2), with impaired cognitive impairment, need walking aids for locomotion or any clinical condition that prevents physical activity and the impossibility of attending the physiotherapy sector twice a week during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-57rnpz	People with hemophilia A using emicizumab in Brazil	Recruiting	Observational	2020-03-23	<NULL>	<NULL>	3647	Brazilian registry of people with hemophilia A using emicizumab (Emicizumab Cases, EMCase)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-57rnpz	<NULL>	Any patient with AH who is going to use or is using MC-Ab may be included in the study, by clarifying and signing the appropriate terms (Free and Informed Consent Form / TALE, for children between 6 and 17 years old; and Term of Free and Informed Consent / ICF, for caregivers responsible for children up to 17 years of age and for patients aged 18 or over), according to Resolution 466, of December 12, 2012, of the National Health Council. service in which the patient is treated must be regularly and ethically registered in the registry, according to the norm of each institution.As patients using the MC-Ab appear, services will be registered through amendments and patients will be included, after signing the appropriate terms (TCLE / TALE). The study will remain open for the capture of new cases for 12 years and each patient will be followed for up to 10 years. The evaluated indicators will be collected at the frequency of each institution, based on the guidelines of the coordinating team. Attention will be paid so that there is at least one evaluation of each indicator before starting to use the MC-Ab.	"Cases that
complete the 10-year follow-up of the study;
discontinue the use of MC-Ab for more than 6 months, for any reason;
wish to leave the registry for any reason;
evolve to death."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-6nhy6h	Effects of physical exercise on cholesterol, glycemia and menstrual cycle of women with micropolicistos in the ovary	Recruitment completed	Intervention	2018-08-27	<NULL>	<NULL>	3648	Brazilian Study on Polycystic Ovarian Syndrome (PCOS)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Departamento de Toco-Ginecologia da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6nhy6h	<NULL>	Age between 18 and 40 years;Body mass index greater than or equal to 18.5 kg / m² and less than 40 kg / m²; Hirsutism, irregular and / or anovulatory menstrual cycles, normal renal and hepatic function;Polycystic appearance of ovaries; No use of medications for at least 3 months; without practicing physical exercises in the last six months or sedentary.	Pregnant women; They present androgen secreting tumors, Cushing&apos;s syndrome, congenital adrenal hyperplasia, hyperprolactinemia (greater than 40 ng / ml) and thyroid dysfunctions; and Diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-24bbzs	Can Hormome replacement therapy of menopause  improve sleep and quality of life in menopausal women with Fibromyalgia?	Recruiting	Intervention	2018-12-01	<NULL>	<NULL>	3649	Influence of the hormone therapy on sleep and quality of life of menopausal women with fibromyalgia	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2018-08-28	Hospital de Clínicas da Universidade Federal do Paraná	Sociedade Evangélica Beneficente de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-24bbzs	<NULL>	Menopausal women with fibromyalgia; with 40 to 60 years old,; and presenting climacteric symptoms	There will exclude from the study the women who won&apos;t be able to comprehend and reply the questionnaires due to their limited cognition or idiomatic; the ones who have presented another associated autoimmune rheumatic disease (systemic lupus erythematosus, rheumatoid arthritis); the patients who have absolute contraindication to the hormone replacement therapy ( breast cancer, endometrium cancer,  acute an prior thromboembolism, acute or/ and severe liver disease,  acute heart disease and uterine bleeding no diagnosed)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-74497t	Acute effect of inspiratory muscle training on inflammation and heart function in patients with obstructive sleep apnea	Recruitment completed	Intervention	2020-03-23	<NULL>	<NULL>	3650	Acute effect of inspiratory muscle training on inflammatory markers, cardiac autonomic activity and cardiovascular variables in patients with obstructive sleep apnea: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Universidade Federal de Pernambuco	Hospital Otávio de Freitas	https://ensaiosclinicos.gov.br/rg/RBR-74497t	<NULL>	Individuals of both sexes diagnosed with moderate or severe obstructive sleep apnea by polysomnography or polygraphy; be between 30 and 70 years old; no history of specific apnea treatment in the last two months; sedentary or insufficiently active according to the International Physical Activity Questionnaire	History of neuromuscular disorders; infectious diseases; immunological diseases; tumors; peripheral vascular diseases; coagulation disorders; liver or kidney disease; severe psychogenic disorders or acute or chronic renal failure; platelet patients; hx of head or neck injury or surgery in the last 3 months; administration of hormones, immunosuppressants, cytotoxins or free radical scavengers; use of medications such as oral corticosteroids, central nervous system depressants, barbiturates and / or muscle relaxants, patients with impaired cognitive impairing the understanding and execution of research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5778vq	Evaluation of endothelial function and cardiac autonomic and this relationship with clinical and functional aspects in patients with isolated chronic obstructive pulmonary disease and the coexistence of heart failure in exacerbation phase.	Recruiting	Intervention	2020-03-24	<NULL>	<NULL>	3651	Exacerbation of COPD and COPD overlap heart failure and noninvasive ventilatory support: impact on endothelial function and cardiac autonomic modulation and relationship among cardiovascular outcomes and clinical and functional aspects	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de São Carlos	Santa Casa da Misericórdia de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5778vq	<NULL>	"CCOPD patients; pulmonary function test values with forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) less than 0.7 and FEV1 less than 80% of predicted; associated with a history of drug treatment and signs and symptoms of COPD exacerbation;
Typical HF signs and symptoms combined with a reduction in left ventricular (EF) fraction less than 50% by Doppler Echo, with forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) less than 0, 7 and lower FEV1 than 80% of the forecast)."	Alcoholic patients and / or drug users who cause chemical dependency; patients using invasive mechanical ventilation; hemodynamic instability; presence of unstable angina; history of myocardial infarction in the last 6 months; patients who exacerbate again within the 30-day period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-998r5b	Clinical evaluation of a fluid material to cover tooth cavities with lesions close to the gum.	Recruitment completed	Intervention	2020-03-24	<NULL>	<NULL>	3652	Clinical evaluation of Methacrylate and Ormocer® fluid composite resins in noncarious cervical lesions.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-998r5b	<NULL>	Patients over 18 years old will be included; presence of at least two non-carious cervical lesions per patient regardless of their location in the dental arch; need of restorative treatment; adequate oral hygiene; absence of motor difficulties that prevent the performance of adequate oral hygiene; absence of periodontal disease active caries lesions and parafunctional habits; at least 20 teeth in function; absence of active removable partial denture clips on the teeth included in the research and that these are not prosthetic pillars; non-carious cervical lesions with a maximum of 50% enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-25pmp2	Exercises to keep your lung and healthy heart	Recruitment completed	Intervention	2020-03-24	<NULL>	<NULL>	3653	Sports university: lung and healthy heart	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Universidade Estadual de Goiás	Leonardo Lopes do Nascimento	https://ensaiosclinicos.gov.br/rg/RBR-25pmp2	<NULL>	"Both sexes;
Age over 18 years;
Possess conditions to perform pulmonary function tests and submaximal effort, for both the same and before any test will undergo Cardiovascular Risk Stratification recommended by the South American Cardiovascular Prevention and Rehabilitation Directive;
Participants stratified as low and moderate risk according to the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR)."	"Be classified as high risk according to AACVPR;
Body Mass Index (BMI)40;
Do not present cognitive and motor conditions to perform pulmonary function tests and submaximal effort."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-228fsy	Evaluation of fractional CO2 laser in vaginal atrophy in menopausal women compared to topical estrogen therapy	Data analysis completed	Intervention	2020-03-25	<NULL>	<NULL>	3654	Study of vascular and cellular proliferation factor and mucous thickness in the vaginal epithelium in menopaused women submitted to vaginal rejuvenation by fractional co2 laser	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-228fsy	<NULL>	Age over 50 years;no menstruation 12 months ago;  presence of symptoms resulting from vulvovaginal atrophy, a conventional Pap smear examination of Frost consistent with atrophic status and who have not undergone hormone replacement in last 3 months	urogenital infection or inflammation of character acute or recurrent;pre-neoplastic lesions;pelvic prolapses; pregnant women; immunosuppressive patients, severe chronic diseases; previous pelvic surgery;use of hormone therapy for less than 3 months;previous pelvic radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-3mm7cs	Metagenomic analysis of the colony of bacteria from the intestine of premature babies undergoing treatment with Colostrotherapy treated by the Unified Health System (SUS): Intervention Study	Not yet recruiting	Intervention	2020-03-25	<NULL>	<NULL>	3655	Metagenomic Analysis of the Intestinal Microbiota of premature infants undergoing treatment with Colostrotherapy treated by the Unified Health System (SUS): Intervention Study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-10	Jessica Santos Passos Costa	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-3mm7cs	<NULL>	"The inclusion criteria for the control group (from HEC) will be: premature newborns
admitted to Neonatal Units, birth weight 1,500g, 32 weeks gestational age, They must be on a zero diet orally and enteral or using total parenteral nutrition (NTP), and / or enteral administration of infant formula and clinically stable, with normal parameters. In addition, to collect the fecal sample, the newborn will be included if the first evacuation was made at the NICU. The mothers of infants, both for the group of intervention, as well as for the control group, will be selected according to the eligibility criteria of your children&apos;s entry into the study"	"Among the exclusion criteria: mother&apos;s, maternal history of substance use psychoactive drugs, drugs, alcohol, presence of 
 psychological disorder, multiple pregnancy from triplets and children of mothers contraindicated for breastfeeding retroviruses and cytomegalovirus). RN: use of vasopressor medication bigger then 10mcg / Kg / min, requirement for immediate surgical intervention, syndromes and / or congenital malformations, neonatal morbidities such as the incidence of patent ductus arteriosus (PDA), sepsis or necrotizing enterocolitis (NEC), The newborn who eliminates meconium in the Obstetric Center (CO)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-466xzz	Effect of preemptive analgesia and desensitization to control painful sensitivity after tooth bleaching	Recruitment completed	Intervention	2020-03-25	<NULL>	<NULL>	3656	Effect of preemptive analgesia and Potassium Fluoride desensitization to control painful sensitivity after tooth bleaching: a controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade de Pernambuco - campus Arcoverde	Universidade de Pernambuco - campus Arcoverde	https://ensaiosclinicos.gov.br/rg/RBR-466xzz	<NULL>	Healthy anterior teeth and not restored; Tooth sensitivity up to Degree 2 in the Schiff index after an air jet; Absence of hypoplasia and teeth stained by fluorosis or tetracycline; having signed the Informed Consent Form	Pregnancy; Lactation; To have a fixed orthodontic appliance; Have previous experience with tooth whitening; Have used any antiinflammatory drug in the last 15 days; have periodontal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-7jz9f2	Physiological Mechanismsof Bariatric Surgery	Recruiting	Intervention	2020-03-25	<NULL>	<NULL>	3657	Physiological Mechanisms in Weight Loss and Glycemic Control of Bariatric Surgery in Obese and Diabetic Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Centro de Estudos do Aparelho Digestivo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jz9f2	<NULL>	age between 18 and 65 years ; BMI higher than 30 ; DM2 confirmed by, in treatment HbA1C higher than 7,1, not in treatment, glyacemia higher than 200mg/dl or HbA1C higher than 7,1 ; Has the ability to understand treatment options and commit to the necessary treatment requirements ; Has willingness to participate in the study and agrees with all treatment arms offered in the study	Previous bariatric procedure ; Anterior complex abdominal surgical procedure ; Cardiovascular impairment including coronary heart disease, cardiac arrhythmias, congestive heart failure, history of stroke, chronic peripheral arterial obstruction ; Renal failure with Creatinine higher than 1.8 mg / dl ; History of chronic liver disease ; Known gastrointestinal disorders including celiac disease, inflammatory bowel disease or other malabsorptive diseases ; Psychiatric disorders including dementia, severe depression, history of suicide attempt, alcohol and drug abuse in the past 12 months ; Pregnant women ; History of neoplastic diseases in the last 5 years ; Previous history of coagulopathies, including DVT and PTE ; Severe lung disease with FEV1 lower than 50% ; ASA IV ; Total extension of the small intestine loops in length that does not allow the surgical technique to be performed for the group that the patient was assigned, maintaining a length of common limb greater than 300cm( does not apply for Sleeve Gastrectomy, since all the limbs are alimentary)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4vyry3	Heart rate variability after heart surgery	Recruitment completed	Intervention	2020-03-25	<NULL>	<NULL>	3658	Heart rate variability in patients undergoing cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-05	Faculdade de Filosofia e Ciencias - UNESP Marília	Faculdade de Filosofia e Ciencias - UNESP Marília	https://ensaiosclinicos.gov.br/rg/RBR-4vyry3	<NULL>	Volunteers of both sexes, over 18, in the preoperative period of cardiac surgery; do not use a pacemaker and do not have arrhythmias	intraoperative complications; need for a pacemaker in the postoperative period; respiratory rate above 35 breaths per minute; peripheral oxygen saturation below 90%; systolic blood pressure above 180 mmHg or below 90 mmHg before the start of the protocol in the intensive care unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-85s3r8	Effect of Laser on Perineal Pain realief after Vaginal Birth	Recruiting	Intervention	2019-09-24	<NULL>	<NULL>	3659	Effect of Low Intensity Laser on Perineal Pain relief after Vaginal Birth: triple blind randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-85s3r8	<NULL>	Women with a history of usual risk pregnancy; older than 18 years; literate; oriented; at most 24 hours postpartum; complaining of perineal pain after vaginal birth; absence of genitourinary pathology	Puerperal infection, hemorrhoids or varicose veins in the vulvar region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-56hhk6	Biomechanical changes of the ankle and foot and the professor&apos;s feet pain	Recruitment completed	Intervention	2020-03-25	<NULL>	<NULL>	3660	Relationship of biomechanical changes in the ankle and foot with the incidence of plantar Fasciitis in professors	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-07-01	UNICESUMAR	UNICESUMAR	https://ensaiosclinicos.gov.br/rg/RBR-56hhk6	<NULL>	The inclusion criteria will be individuals who work at the institution on a labor basis; with due registration in the work card; and who have pain in the plantar region of the foot for at least seven days.	The exclusion criteria will be individuals who are outside the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4r8cb9	Clinical simulation for teaching of sexuality of individuals with spinal cord injuries	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3661	Clinical simulation for teaching of sexuality of patients with spinal cord injuries	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-29	Faculdade de Enfermagem da Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4r8cb9	<NULL>	"Students regularly registered in undergraduate nursing courses who attended or are attending
semiology and semiotechnics / fundamentals and some discipline that contemplates the content of
Women&apos;s Health."	Students who are absent from any stage of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-7t7d4d	Effect of desensitizing gel on sensitivity caused by dental bleaching	Recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3662	Effect of desensitizing gel on sensitivity induced by dental bleaching in the office	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7t7d4d	<NULL>	Patients older than 18 years of age. Male and female. With good general and oral health. Teeth free of caries lesions. Have teeth in color A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) and that they agree with the informed consent term (TCLE).	Will be excluded volunteers who have already undergone dental bleaching. Who have dental prosthesis; previous dental sensitivity; severe dental dimming by pathologies or medications; fixed orthodontic appliance. Who are pregnant or breastfeeding and who are making continuous use of some medicine that reduces the sensitivity dental.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-2cp8t8	Evaluation of the temperature of the irrigant during root canal treatment in patients with the use of several irrigant agitation methods	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3663	In vivo evaluation of the irrigant agent temperature after shaking by easy clean, endo xp finisher and ultrasonic passive irrigation in the apical third	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-10	Geraldo Edson Freitas Athayde Moraes	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-2cp8t8	<NULL>	Health patients; both gender; no smokers; age between 19 and 58; diagnosed with pulp pathology	"Patients who did not agree with the study;
teeth with incomplete rhizogenesis;root with curvature greater than 5°; teeth with more than one root canal; teeth with previous root canal treatment; teeth with calcified root canal; teeth were it was not possible to perform the patency with K# 5 file"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-6vfwnx	Effects of respiratory muscle training on functional capacity in neurological patients	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3664	Effect of respiratory muscle training on functional capacity in individuals with Parkinson&apos;s disease or post stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-30	Universidade Federal da Bahia	Cnetro Universitário Social da Bahia UNISBA	https://ensaiosclinicos.gov.br/rg/RBR-6vfwnx	<NULL>	Age greater than 18 years; confirmed medical diagnosis of Parkinson&apos;s disease with a degree of severity between 1 and 3 according to the HOEHN &amp; YAHR classification or stroke diagnosed six months ago; ability to understand and perform respiratory maneuvers with appropriate technique; absence of pulmonary or neuromuscular disease; except Parkinson&apos;s disease.	Will not be included in the study, individuals who present cognitive alterations according to the Mini Mental State Examination, observing the following score; if illiterate; score less than 19 points; with 1 to 3 years of schooling; score below 23 points; with 4 to 7 years of schooling; score below 24 points, and above 7 years of schooling; score less than 28 points. They present osteomioarticular lesions that make physical activity impossible; chronic uncontrolled diseases such as hypertension; diabetes mellitus and chronic pain. Unstable cardiovascular diseases such as acute heart failure; recent myocardial infarction; unstable angina and uncontrolled arrhythmias. Lung or other diseases that adversely affect the respiratory pump, including asthma and chronic obstructive pulmonary disease. Use of alcohol and other toxic substances; have facial paralysis or difficulty in sealing the mouthpiece during training. In addition to the aforementioned criteria; participants will be excluded in cases of absences exceeding three at the end of eight weeks of treatment; present osteomioarticular or cardiovascular changes acquired during the treatment period that make physical activity and / or inspiratory muscle training impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-23p4zr	The use of lasers with antimicrobial drugs to treat infected wounds in people with diabetes: randomized clinical trial	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3665	Laserterapy associated with photodynamic therapy in the treatment of infected wounds in persons with diabetes: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Maria Girlane Sousa Albuquerque Brandão	Universidade Internacional da Integração da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-23p4zr	<NULL>	Individuals aged 18 years or over; being diabetic and presenting an infected wound (evaluation of the wound will be carried out by analyzing clinical signs: presence of odor, exudate, discoloration of the tissues inside and margins of the wound, edema, friable and hemorrhagic granulation tissue); attend the clinic on pre-established days.	Suspected or confirmed pregnancy; use immunosuppressive drugs; being on antibiotics or having finished treatment less than 30 days; use of any topical medication on the wound for less than seven days; diagnosis / Treatment of Carcinoma; presenting a wound with an area greater than 144 cm2; anemia (Hb less than 12 g / dL); Chronic Kidney Failure; osteomyelitis; being under the influence of alcohol or psychotropic substances; chronic malnutrition; peripheral vascular insufficiency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-48yfcc	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3666	Comparison of the Acute Effect of different types of physical and cognitive and combined stimuli under the cognitive, autonomic and motor function of the patient with Chronic Obstructive Pulmonary Disease a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-48yfcc	<NULL>	Medical clearance for testing; diagnosis of COPD; being older than 55 years; without exacerbation or infections for less than 4 weeks; without performing physical activity for at least 4 weeks	Dizziness; Chest pain; severe dyspnoea; SBP greater than 220mmHg and DBP greater than 120mmHg; SpO2 less than 90%; Difficulty adapting to virtual reality; Difficulty using the cycle ergometer; interruption of intervention on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-7xmh8d	Effect of strength training on body composition, biochemical markers and quality of life in patients with chronic kidney disease	Recruitment completed	Intervention	2020-03-26	<NULL>	<NULL>	3667	Effect of strength training in patients with chronic kidney disease	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-08	Universidade do estado do rio grande do norte	Universidade do estado do rio grande do norte	https://ensaiosclinicos.gov.br/rg/RBR-7xmh8d	<NULL>	Patients of both sexes aged 18 to 65 years, undergoing HD treatment with a minimum time of three months, with vascular access by arteriovenous fistula, with independent ambulation. All participants responded to an anamnesis prior to study initiation.	Patients who were engaged in an exercise program, with physical disability and musculoskeletal limitations that precluded assessments and exercise protocol, with a history of heart attack in the last six months, with recent hospitalization history (&lt;3 months), decompensated diabetes and blood pressure, pregnant , pacemaker users and with less than 70% attendance of training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-9mwft7	Social support of family caregivers of elderly people with high dependence: a quasi-experimental study	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3668	The results of an intervention on the social support of family caregivers of elderly with high dependence.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9mwft7	<NULL>	Be 18 years of age or older; Both sexes; Being a family caregiver for at least three months; Reside in the municipality of Ribeirão Preto; Own smartphone	Being a professional caregiver for the elderly; Elderly resident of LTI; Elderly not being followed up on an outpatient basis at GEAD	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-92d653	Molding techniques and their impact on retention in removable dentures	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3669	Functional impression techniques in conventional full dentures: Impact on retention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-19	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-92d653	<NULL>	Totally toothless bimaxillary patients who seek total dental prosthesis service at the Faculty of Dentistry of Pernambuco (FOP / UPE) seeking their rehabilitation; Participants who agree to participate in this research by signing the Free and Informed Consent Term (ICF); Participants over 18 years old; Completely edentulous participants for at least 1 year.	Patient with retentive rim; Patients with neoplastic and non-neoplastic proliferative processes in the oral mucosa; Patients with changes in the oral mucosa resulting from microbial infections; Patients with neuromuscular disorders; Xerostomia; Kelly syndrome patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-43k52n	Health education actions to improve the quality of life of adults affected by syndrome	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3670	Repercussions of nursing actions with health education on the quality of life of adults affected by syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual do Sudoeste da Bahia	Isleide Santana Cardoso Santos	https://ensaiosclinicos.gov.br/rg/RBR-43k52n	<NULL>	Having three clinical conditions for metabolic syndrome according to the criteria of the National Cholesterol Education Program’s Adult Treatment Panel III; being an adult aged 25 years or older up to 59 years 11 months and 29 days; not have cognitive and / or motor deficits that prevent you from responding to the instruments or taking the exams and accepting to participate in the study.	Adults with type I diabetes; adults with cognitive impairment; adult pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-7yv765	Evaluation of inflammatory markers in patients undergoing a short-term aerobic exercise program while hospitalized due to acute exacerbation of COPD	Recruitment completed	Intervention	2020-03-26	<NULL>	<NULL>	3671	Evaluation of inflammatory markers in patients undergoing a short-term aerobic exercise program while hospitalized due to acute exacerbation of COPD	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2012-07-01	Faculdade de Medicina de Botucatu /UNESP	Faculdade de Medicina de Botucatu /UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7yv765	<NULL>	"Patient hospitalized for exacerbated COPD; 
both genders; without limitation of mobility."	Level of awareness by score Glasgow score less than fifteen; Borg dyspnoea score greater than seven; unstable heart disease; limited mobility; hemodynamic instabilit; mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-9rwqr3	Clinical study on gingival inflammation in teeth restored with ceramic veneers with and without finish line. Evaluation by clinical parameters and by bacteria and inflammatory mediators present in the gingival crevicular fluid.	Not yet recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3672	Influence of ceramic veneers cemented over teeth with and without finish line on the inflammatory mediators and microbiota of gingival crevicular fluid. Clinical, controlled, randomized, blind, prospective and longitudinal study using ELISA and RT-PCR	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-9rwqr3	<NULL>	Patients who require ceramic veneers restorations in the region between teeth 15 to 25; healthy teeth and in good periodontal health; the need to close diastemas; eliminate dead spaces; correct shape and dental contour with aesthetic and / or functional justification attested by diagnostic waxing.	Periodontal disease active; loss of insertion; probing depth greater than 3 mm; bleeding on probing in more than 10% of the evaluated sites; radiographic bone loss; pregnancy, diabetes mellitus; autoimmune diseases and other uncontrolled systemic changes with a detrimental effect on periodontal tissues; users of controlled drugs; presence of hormonal or vitamin deficiency; history of recent use (less than 3 months) of anti-inflammatories or antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-3w29vx	Evaluation of radiofrequency efficacy for the treatment of refractory trigeminal neuralgia	Recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3673	Percutaneous radiofrequency over sham procedure for the treatment of refractory trigeminal neuralgia (THE PROVE STUDY): a double-blind, randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3w29vx	<NULL>	"Patients over 18 years old
Diagnosis of classic or idiopathic trigeminal neuralgia
rigeminal neuropathic pain refractory to clinical treatment for at least 6 months."	"Patients under 45 years old
Patient refusal
Mandatory use of anticoagulants or antiplatelet agents, except AAS.
Presence of local or systemic infection
Psychiatric diseases that impair the assessment of the effectiveness of the procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-4672xj	Impact of the Radiofrequency Identification System of the Motiva Implant on Breast Magnetic Resonance	Recruitment completed	Observational	2020-03-27	<NULL>	<NULL>	3674	Impact of RFID-M System on Magnetic Resonance of Breasts	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Grupo Fleury Medicina e Saude	Motiva Implants	https://ensaiosclinicos.gov.br/rg/RBR-4672xj	<NULL>	29 women who underwent breast reconstruction after mastectomy and 70 underwent cosmetic inclusion with a silicone implant Motiva SmoothSilk	Patient who has any contraindications to entering MRI or who refused to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-2hyztp	Clinical alternatives for greater efficiency of home whitening. Effects of using trays with and without reservoirs	Recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3675	Clinical Alternatives for greater Effectiveness of monitored Home Bleaching treatment. Effects of using trays with and without reservoirs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-2hyztp	<NULL>	The volunteers to be included in the study must be aged between 18 and 25 years, absent caries lesions, defective and / or fractured restorations, periodontal diseases and dental elements with spontaneous pain; healthy oral soft tissues and good systemic condition; who do not have a history of adverse reaction to peroxides and anterior upper and lower teeth with a minimum A2 color	Those with restorations on the buccal surface of the central, lateral and canine incisors will be excluded; those with fixed orthodontic appliances or containing resinous residues on the vestibular surface after removal; pregnant or lactating women; smokers and those who routinely use alcohol; those who did not accept the research consent form; those who have had lightening treatment before and those with teeth that had stains due to tetracycline, fluorosis and pulping.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-9sdf3k	Study of artificial saliva with enzyme system for patients with dry mouth complaint after radiotherapy in head and neck region	Recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3676	A randomized, double-blind, placebo-controlled study of the salivary substitute with enzymatic system for xerostomia in patients irradiated in the head and neck region	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-19	Fundação Antonio Prudente	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9sdf3k	<NULL>	Patients older than or equal to 18 years and less than 75 years;patients diagnosed with CPB of oral cavity, oropharynx or nasopharynx; Clinical Stage II or higher;patients submitted to IMRT or RTC3D, between 6 and 12 months, with a minimum dose of 45 Gy in cervicofacial fields and with radio-induced xerostomia.	Patients using cholinergic drugs such as betanecol chloride, pilocarpine and cevimeline;patients with previous history of radiotherapy and / or surgery in the head and neck region;patients submitted to surgery; Patients with metastatic disease;patients who present difficulties in completing the quality of life questionnaire;patients in clinical conditions or impairment of general health status that prevent them from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-2gvk3d	Effect of Oxytocin on Postmenopausal Genital and Urinary Symptoms: Randomized and Double-Blind Study	Recruitment completed	Intervention	2020-03-27	<NULL>	<NULL>	3677	Effect of Oxytocin in Genitourinary Syndrome: Randomized and Double-Blind Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gvk3d	<NULL>	Spontaneous menopause in the last 5 years; any age; denial of the use of hormone therapy in the last 12 months.	History of previous or present malignant disease; previous or present endometrial hyperplasia and an outdated gynecological routine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8x8v2r	Music in the pain of the term newborn undergoing venipuncture: Randomized Clinical Trial	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3678	Music in the pain of the term newborn undergoing venipuncture	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-09	Universidade Federal do Ceará - UFC	Hospital São Camilo Cura d'Ars	https://ensaiosclinicos.gov.br/rg/RBR-8x8v2r	<NULL>	Newborns with clinical indication of venipuncture for blood test collection; newborn with birth gestational age equal or greater than 37 and smaller 42 weeks, considering the time of amenorrhea or ultrasound performed in the first trimester of pregnancy.When the data was not available, the New Ballard evaluation methods were considered;Newborn with score on the APGAR index bulletin equal or greater than 7 in the 5th minute of life; newborn who underwent Neonatal Hearing Screening.	Newborn using drugs that interfere with pain perception (nociception), such as opioid analgesics and other types of sedatives;newborn whose mother may be breastfeeding using medications that interfere with pain perception (nociception), such as opioid analgesics; newborns undergoing surgical procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-3t3jvr	The use of mother&apos;s milk in newborns with gastroschisis	Recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3679	Colostrotherapy in newborns with gastroschisis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-31	Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira IFF/ Fiocruz	Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira IFF/ Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-3t3jvr	<NULL>	Newborns; both genres; born with gastroschisis; born in the hospital of origin	Newborns with a maternal history of recent drug use (before hospitalization and delivery); infection with the human immunodeficiency virus (HIV); human T cell lymphotropic virus (HTLV); those who die in the first days of life before completing the oropharyngeal administration protocol; mothers are unable to remove the required volume of colostrum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-5q4m7t	Acute effect of treadmill exercise on blood viscosity and IGF-1 protein in Alzheimer&apos;s disease	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3680	Acute effect of aerobic exercise on blood viscosity and IGF-1 in Alzheimer&apos;s disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Unesp - Universidade estadual paulista	Ufabc - Universidade federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5q4m7t	<NULL>	Older adults over 60 years of age, of both sexes; Older adults with clinical diagnosis of Alzheimer&apos;s disease, Level of mild dementia severity according to the Clinical Dementia Rating Score (CDR) (MORRIS, 1993; MONTAÑO; RAMOS, 2005). The adoption of this criterion is due to the nature of the specific procedures of the proposed physical exercise intervention protocol, which requires a certain level of understanding of the activities by the elderly. Availability to participate in the activities proposed by the researcher; Agree and sign the Free and Informed Consent Term based on Resolution 466/12 of the National Health Council.	Older adults with coronarian disease, cardiac arrhythmia, non-controlled hypertension and angina symptons or any restriction to physical activity; Older adults with visual, hearing, vertiginous syndrome non-corrected impairment impairment or another limitation that prejudices locomotion; Older adults with another neuropsychiatric condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-222dr8	Study in children with Obstructive Sleep Apnea, after surgery, treated with a dental appliance or speech therapy	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3681	Polysomnographic study in children with residual Obstructive Sleep Apnea Syndrome treated with Rapid Maxillary Expansion and / or Myofunctional Therapy or Orthopedic Mandibular Advancement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Ciência Médicas - Unicamp	Universidade de Roma La Sapienza	https://ensaiosclinicos.gov.br/rg/RBR-222dr8	<NULL>	Children of both genders from 5 to 11 years old; with residual obstructive sleep apnea after adenotonselectomy	malformations; syndromes with craniofacial involvement; children undergoing orthodontic, orthopedic and myofunctional therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-7zyqq8	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3682	Effect of the lower limbs cycle ergometer associated with conventional physiotherapy in preserving the mobility, morphology and muscle strength of neurocritical patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7zyqq8	<NULL>	"diagnosis of acute neurological injury; aged between 18 and 65 years; use of invasive mechanical ventilation (IMV); 
with more than 24 hours of acute brain event or neurosurgery; admitted to the ICU"	diagnosis of Deep Venous Thrombosis (DVT); diagnosis of brain death (BD); no motor response to the stimulus of the electrostimulator; present criteria for interrupting or not performing the cycle ergometer more than 2 consecutive times or more than 5 times during the ICU stay; express request from a patient or family member to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-78yqfn	Effects of virtual games to activate the brain and well-being of individuals with spinal cord injury	Recruitment completed	Intervention	2020-03-30	<NULL>	<NULL>	3683	"Effects of virtual reality, brain activation and perception of the well-being of
individuals with spinal cord injury"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade de Franca	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-78yqfn	<NULL>	"Experimental Group: participants of both sexes; age between 20 to 60 years; diagnosis
clinical picture of complete and / or incomplete spinal cord injury; minimum injury time of one year; etiology of traumatic injury; sedentary. Control group: participants of both sexes; age between 20 to 60 years; without any type of disability; sedentary."	"Experiment Group: participants with significant orthopedic impairments that could limit sitting posture (such as severe contractures or cutaneous lesions on the lower limbs); present devices for spinal stabilization that limits mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury (for example, stroke); Disease
Alzheimer&apos;s; Vascular Dementia; Mixed Dementia; Lewy Bodies Dementia; Frontotemporal dementia; clinical diagnosis of depression; use of antidepressant drugs and cognitive impairment. Control group: participants with significant orthopedic damage that could limit sitting posture (such as severe contractures or cutaneous lesions on the lower limbs); present devices for spinal stabilization that limits mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury (for example, stroke); Disease Alzheimer&apos;s; Vascular Dementia; Mixed Dementia; Lewy Bodies Dementia; Frontotemporal dementia; clinical diagnosis of depression; use of antidepressant drugs and cognitive impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-2yjtsn	Effect of a Health Education Program on the knowledge and training of pelvis muscles in women in the treatment of urinary loss	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3684	Effect of a Health Education Program on the knowledge and training of pelvic floor muscle in women in the treatment of Urinary Incontinence of Effort: a randomized study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-08-12	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2yjtsn	<NULL>	The study will include women with complaints of urinary loss; over 18 years; who have never received training for MAP; who can read and write and understand the Portuguese language	Those who report or present any psychiatric disorder; cognitive deficit; neurological or incapacitating disease; who are pregnant, last child less than a year and previous surgery to correct UI; will be excluded; regardless of the time that was performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8dxp8m	Effect of Arginine-containing toothpaste on mineral gain and bioquimic and microbian composition of the dental plaque formed in situ	Data analysis completed	Intervention	2020-03-30	<NULL>	<NULL>	3685	Effect of Arginine-containing dentifrice on remineralization and bioquimic and microbian composition of the biofilm formed in situ	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-04-03	Faculdade de Odontologia da UFRGS	Faculdade de Odontologia da UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-8dxp8m	<NULL>	undergradueted and gratueted students in Dentistry at UFRGS;both genders; a favorable systemic health condition; not having used antibiotics in the 2 months preceding the study.	have an unfavorable systemic health condition; have used antibiotics during the 2 months preceding the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-5gkng5	The Effect of Multilayer Silicone Foam compared to Transparent Film in Pressure Injury Prevention on Heels Due to the Surgical Position	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	3686	Effectiveness of Multilayer Silicone Foam compared to Transparent Polyurethane Film in Pressure Injury Prevention on Heels Due to Surgical Positioning: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5gkng5	<NULL>	patients hospitalized at the Hospital Universitário de Santa Maria during the preoperative period of elective surgery of digestive or cardiac specialty; age equal to or greater than 18 years; evaluated for follow-up at least 12 hours before the surgical procedure by the researcher or research assistants; with the heels pair intact until the second evaluation (preoperative in the surgical center)	American Society of Anesthesiologists score = VI; pregnant or suspected pregnancy; with impaired verbal communication without an accompanying person, or altered level of consciousness without an accompanying person; lower limb amputation; fracture in one of the lower limbs in use of skeletal traction or external fixator, plaster, dressing that forbid access to heels; surgical procedure performed exclusively in the prone position	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8d5gwq	Evaluation of the use of the Partial Wrapping of the Premature Body by a Sheet to perform Respiratory Physiotherapy	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3687	Effect of Modified Wrapping on Respiratory Physiotherapy Techniques in Premature - an intervention proposal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-8d5gwq	<NULL>	The following inclusion criteria were considered: male and female preterm infants, gestational age of up to 37 weeks (&lt;259 days), postnatal age greater than 72 hours of life, weight ?2,500 grams, and medical prescription to perform chest physiotherapy with the need for nasotracheal/endotracheal aspiration.	"The following exclusion criteria were considered: infants under sedative effect, preterm infants with congenital malformations and/or external devices preventing modified swaddling, presence of convulsive seizures, use of surfactant, therapeutic hypothermia, and blood transfusion or any other conditions that presented contraindication for chest physiotherapy by the medical team.
In this study, discontinuity occurred for participants who freed from the swaddle during the intervention or who were transferred to another ventilatory assistance device during the study follow-up period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8rkrr3	The Effectiveness of Strengthening Respiratory Muscles and their Relationship with Fatigue in Patients with Multiple Sclerosis	Recruitment completed	Intervention	2020-03-31	<NULL>	<NULL>	3688	The Effects of Respiratory Muscle Strengthening in relation to Pulmonary Fatigue in Patients with Multiple Sclerosis and with Hypovitaminosis D	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Faculdade de Medicina da Universidade Federal de Goiás	Faculdade de Fisioterapia da Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rkrr3	<NULL>	"Patients with clinical diagnosis of Multiple Sclerosis in remitting-recurrent form according to the revised McDonald criteria;
EDSS (Expanded Disability Status Scale) up to 6.0 according to the Kurtzke scale;
Stable phase of the disease (after any 30 days of the outbreak);
Orbicular strenght of the lips sufficient to support the mouthpiece during respiratory assessment."	"Any neurological disorder other than Multiple Sclerosis;
History of primary cardiopulmonary diseases;
Difficulty to understand simple instructions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8qngsh	Experimentation of an innovative strategy for the dietary management of overweight in children	Recruitment completed	Intervention	2020-03-31	<NULL>	<NULL>	3689	Dietary management of obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-8qngsh	<NULL>	Overweight children between six and nine years old; both sexes; considering the range of Body Mass Index per age between higher or equal to +1 and under +3 z scores of the reference for child growth, according to gender, by WHO 2007.	Children with congenital or hereditary diseases; diagnosis of hypertension; Body Mass Index per age higher or equal to +3 z score of the reference curve, according to gender, by WHO 2007.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-3t597f	Comparison between the use of hand and mechanized files in the treatment of primary molar canal	Recruitment completed	Intervention	2018-05-09	<NULL>	<NULL>	3690	Comparative analysis between hand files and rotary file in the endodontic treatment of primary molars - clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-12	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-3t597f	<NULL>	Literate caregivers; children aged 4 to 10 years; Free and Informed Consent Form signed; Term of Assent signed; children without systemic involvement in the general health; continuous use of medicines; have not taken analgesics in the last 12 hours; mandibular and maxillary primary molars; pulp necrosis; irreversible pulpitis; inter root pathological lesion; radiolucent periapical lesion not involving the germ of the permanent tooth or more than half the length of the roots; up to 2/3 of the radicular root length	Teeth that can not be filled; teeth that can not receive absolute isolation; external pathological reabsorption; calcifications; teeth submitted to previous endodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6343y7	Effect of different types of physical exercise on cardiovascular risk factors in obese adolescents	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3691	Effect of high intensity interval training (HIIT) and aerobic training on cardiovascular and genetic risk in obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal do Paraná	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-6343y7	<NULL>	Individuals of both sexes, aged between 10 and 17 years; Did not present any contraindication to the tests, including absence of cardiac, pulmonary and osteoarticular diseases that compromised muscular strength tests; Do not present contagious diseases of skin (chills, dermatitis, mycoses) that indicate the practice of activities in water; Not to perform other regular physical activity in the last six months, except school physical education (120 min / week); Not participating in any weight loss program; Do not use any medication that interferes with the results of the research.	Obese children and adolescents with infectious-contagious or dermatological diseases that impede participation in the group of aquatic physical exercises; Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; Not participate in the second physical evaluation of the project; Participation in at least 75% of classes for exercise groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-7bvg7p	Effect of stretching duration for lumbar muscles on electrical activity and stability of multifidus and lumbar iliocostal muscles	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3692	Acute effect of stretching the paravertebral muscles, and their maintenance time, on a myoelectric activity of the multifunctional and iliocostal lumbar muscles, and on the static skills and statistics of the lumbopelvic region	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-7bvg7p	<NULL>	Volunteers with no history of spinal or lower limb disorders, whether acute or chronic, in the last 12 months; and who did not practice physical activity regularly and systematically for at least twice a week	Volunteers with a history of abdominal, hip and spine surgery, regardless of the time taken; pregnant women; that made use of muscle relaxants; that did not meet the entire collection schedule; or EMG signals with poor record quality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-35msdt	Interference of Tetanus Stimulation in Monitoring Muscle Relaxation with Rocuronium in General Anesthesia	Recruiting	Intervention	2020-03-31	<NULL>	<NULL>	3693	Effect of Tetanic Stimulation prior to Train-of-Four on Muscle Response Stabilization Time in patients 60 to 80 years	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-21	Hospital Universitário Gaffrée e Guinle- Universidade Federal do Estado do Rio de Janeiro	Hospital Universitário Gaffrée e Guinle- Universidade Federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-35msdt	<NULL>	both genders;age 60 to 80 years;physical state American Society of Anesthesiologists (ASA) I to III;body mass index 18.5 to 29;surgeries lasting 60 minutes or more;patients who will undergo surgery with a single dose of neuromuscular blocking drug	refusal to participate in the study;presence of neuromuscular diseases, renal or hepatic dysfunction;history of difficult airway predictors;use of furosemide, aminoglycosides, aminophylline, azathioprine, cyclophosphamide, anti-inflammatories and magnesium;allergy to the drugs used in the study;intercurrences in the perioperative that need alteration in the project;participants who already participate in other clinical studies within the study hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6qycxj	Comparison between two types of Progesterone in endometrial preparation for Transfer of Thawed Embryos	Recruiting	Intervention	2020-03-31	<NULL>	<NULL>	3694	Comparison between Micronized Vaginal Progesterone and Oral Didrogesterone in endometrial preparation for Transfer of Thawed Embryos	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-12-01	Centro de Referência da Saúde da Mulher	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6qycxj	<NULL>	Patients undergoing embryo cryopreservation and thawed embryo transfer due to risk of ovarian hyperstimulation syndrome; excess embryos after pregnancy failure in the fresh transfer; loss of transfer by safe endometrium; who underwent preimplantation genetic testing.	Women with an endometrium smaller than 7 mm after endometrial preparation with estrogen. Patients with a history of recurrent miscarriages; severe male factor; uterine diseases; presence of hydrosalpinx. Patients who had a dominant follicle even with estrogen administration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-3w3sry	Changes in vital signs, according to the position of the belly up, belly down, and kangaroo, in newborns admitted to the Neonatal ICU	Recruitment completed	Intervention	2020-04-01	<NULL>	<NULL>	3695	Changes in heart rate, respiratory rate and peripheral oxygen saturation, according to the supine, prone and kangaroo positions, in newborns admitted to the Neonatal ICU	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-19	Universidade Federal do Parana	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3w3sry	<NULL>	Newborns with gestational age between thirty and thirty-seven weeks; weighing between 1000 and 1499 gr; of both sexes; under spontaneous breathing; clinically stabl;, admitted to the Neonatal ICU of Hospital de Clínicas da UFPR and can be manipulated to different positions (prone, supine and kangaroo)	Newborns in invasive and noninvasive mechanical ventilation; if not in the appropriate size and weight range; if the mother is unable to perform the kangaroo method if this is the posture to be evaluated in the child; not being in the unit intensive care where research is being conducted; not having parental authorization; being unstable and / or unable to handle at the time of the assessment; being in palliative care; having performed thoracoabdominal surgeries that make handling and positioning impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-9f6jkm	Effect of respiratory therapy in adults with bruxism and respiratory dificult during sleep	Recruitment completed	Intervention	2020-01-28	<NULL>	<NULL>	3696	Effect of respiratory therapy in adults with Bruxism patients and associeted respiratory events	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9f6jkm	<NULL>	"Patients aged 18 to 65 years;
Patients identified with sleep bruxism and associated respiratory events (apnea and mild to moderate hypopnea) by polysomnography."	Use of intraoral device; Associated severe apnea / hypopnea; Severe skeletal changes affecting upper airways; Chronic medical conditions that affect OSAHS such as stroke; Failure to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8bv3dz	Clinical Trial of a Paste Endodontic based on calcium hydroxide and Aloe Vera	Recruitment completed	Intervention	2020-04-02	<NULL>	<NULL>	3697	Effectiveness of Endodontic paste based on Calcium Hydroxide and Aloe vera: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal do Piauí	Centro Integrado Lineu Araújo	https://ensaiosclinicos.gov.br/rg/RBR-8bv3dz	<NULL>	Healthy volunteers aged 18 to 65, with at least an anterior tooth with apical periodontitis between 01 mm by 01 mm and 05 mm by 05 mm, requiring endodontic treatment.	Presence of history of allergies to materials used in the research; history of general health involvement, pregnant or lactating women; teeth with previous endodontic treatment history; teeth presenting calcifications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-73jpwy	The influence of health education on the promotion of physical activity and memory in sedentary elders	Recruitment completed	Intervention	2018-08-13	<NULL>	<NULL>	3698	The influence of an extended educational intervention for a promotion of physical activity and cognitive health in sedentary older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Estadual de Ciências da Saúde de Alagoas	University of Miami	https://ensaiosclinicos.gov.br/rg/RBR-73jpwy	<NULL>	Individuals over 65 years of age; sedentary individuals with less than 150 minutes of moderate physical activity per week) verified through the International Physical Activity Questionnaire; with subjective complaints of memory impairment or mild cognitive impairment with scores between 18 and 29 in the Mini Mental State Exam, varying according to level of schooling. All must agree to sign the informed consent form to participate in the research.	Individuals will be excluded from the project: illiterate;  with health problems that can prevent safe walks, evaluated by PAR-Q; with psychological/psychiatric problems that may interfere with full participation. The exclusion criteria will be identified by the researcher at the time of recruitment of the research subject during the completion of the screening form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-2fjdnt	Effects of Yoga Thai massage and conventional stretching in women with low back pain	Recruitment completed	Intervention	2020-04-02	<NULL>	<NULL>	3699	Comparative study of Yoga Thai massage effects and conventional stretching in women with low back pain: controlled clinical trial, randomized and blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-13	Instituto Federal do Paraná	Instituto Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2fjdnt	<NULL>	"Women between 20 and 40 years old;
They must have complaints of nonspecific low back pain for more than 1 month;
Do not practice any physical activity that favors the improvement of low back pain and / or flexibility (yoga, pilates, stretching classes);
Accept to be part of the research by signing the free and informed consent form."	"Have lower back pain for less than 1 month;
Have any diagnosis of degenerative pathology in the lumbar spine/hip;
Previous previous surgeries: such as hip prosthesis, fixation of vertebrae by means of metal plates and screws;
Present sciatic nerve irradiation evaluated by Lasègue test
Present associated pathologies, such as: inflammatory processes of the bursa and tendons;
Have a congenital diseases;
Having uncontrolled hypertension and thyroid disorders;
Be pregnant;
Diagnosis of neoplastic pathology."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-47gbn4	Impact of overdentures retained by a single mandibular implant on the swallowing threshold, quality of life and speech of edentulous elderly	Recruitment completed	Intervention	2018-03-01	<NULL>	<NULL>	3700	Impact of overdentures retained by a single mandibular implant on the swallowing threshold, quality of life and speech of edentulous elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Estadual de Campinas- Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas- Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-47gbn4	<NULL>	It will be selected 18 elderly over 60 years old, according to the following inclusion criteria: to be totally edentulous in the upper and lower dental arches, and to use upper and lower dentures for at least 1 year; to have posterior mandibular alveolar process sharply reabsorbed, with height less than or equal to 15 mm³,and lower anterior alveolar ridge compatible with the implant, and with a minimum bone volume of 8 mm, condition detected after radiographic examination and / or tomographic; to be a Portuguese native speaker and finally to be literate.	The elderly with parafunctional habits; craniofacial malformation; moderate to deep hearing loss (evaluated by tonal audiometry),  which are users or not of any individual sound amplification apparatus; cognitive impairment (evaluated through the application of the Mini Mental State Examination) ; aged with some language disorder; aged with severe speech disorder; elderly already done laryngeal surgery; aged who had experience with speech evaluations and with psychophysical; elderly with symptoms of temporomandibular joints and / or chewing muscles; aged with uncontrolled systemic diseases; neurological diseases, such as: ischemic or hemorrhagic stroke, traumatic brain injury, Parkinson&apos;s disease, Alzheimer&apos;s disease; elderly with psychiatric disorders which change the articulation of speech and the course of this study; smokers; alcoholics; aged who have performed head and / or neck irradiation due oncological diseases will  be eliminated of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-98myd6	Comparison study between chamomile and calendula creams to prevent radiation-induced skin lesions	Recruiting	Intervention	2020-04-03	<NULL>	<NULL>	3701	Comparative study of chamomile and calendula creams in the prevention of radiodermatitis: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-27	Daniele Machado Oliveira Andrade	Daniele Machado Oliveira Andrade	https://ensaiosclinicos.gov.br/rg/RBR-98myd6	<NULL>	Both sexes; age equal to or over 18 years; diagnosis of head and neck cancer	History of radiotherapy in the same field of treatment; previous report of allergic reaction to chamomile or calendula	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-66vrz8	Treatment of patients with severe periodontal disease by common periodontal cleaning or with surgery using an ultrasound device	Data analysis completed	Intervention	2020-04-03	<NULL>	<NULL>	3702	Surgical and non-surgical treatment of periodontitis with ultrasonic debridement: a controlled randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal de Goiás	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-66vrz8	<NULL>	Patients with diagnostic of chronic periodontitis, by presence of periodontal pockets with clinical attachment loss of 5 mm, with bleeding on probing, radiographic evidence of bilateral intrabony defect limited to two or three walls determined by periapical radiographs, and the absence of a medical condition that could affect the progression of periodontal disease.	Pregnant or lactating; smokers; Patients who required antibiotic premedication; patients who received antibiotic treatment in the previous 6 months; patients who received a course of periodontal treatment within the past 6 months; tooth with furcation involvements; tooth with endodontic treatment and non-vital tooth; tooth presenting mobility and/or traumatic occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6qq5zz	The use of instruments to identify severity and mortality to assess Autonomic Modulation in patients admitted to the ICU	Recruiting	Observational	2020-04-03	<NULL>	<NULL>	3703	Correlation of the severity and mortality rate identified by the Apache and Sofa instruments with changes in the Autonomic Modulation of patients admitted to the ICU	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-25	Hospital de Clinicas - Universidade Federal do Triângulo Mineiro	Hospital de Clinicas - Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6qq5zz	<NULL>	Patients admitted to the General Intensive Care Unit of HC - UFTM, of both sexes, will be included in the study; aged 18 or over; with predictors of risk of death and severity performed within 24 hours of admission.	Patients admitted to the ICU over 48 hours after admission will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-5jzmqq	Efficacy of Duloxetine analgesia after large intestine removal	Recruiting	Intervention	2020-04-03	<NULL>	<NULL>	3704	Efficacy of perioperative Duloxetine analgesia in post-colectomy pain: prospective, randomized, double-blind, placebo-controlled study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5jzmqq	<NULL>	ASA I, II and III patients; aged 18 to 85 years; of both sexes; who underwent open elective colectomy under general anesthesia and allow the use of their data for research activities by signing their Informed Consent Terms (ICF).	Patients under 18 and over 85; patients with renal or hepatic impairment; history of drug or alcohol abuse; history of chronic pain or daily opioid intake; ASA IV patients; urgency / emergency surgical procedure; pregnancy or puerperal period; history of psychiatric illness, cognitive disorders and / or seizures; history of use of analgesics and / or medications with central nervous system effects within three days prior to surgery; known allergy to duloxetine or other compositions used in the study; coagulopathies; uncooperative, legally incapable or contraindicated patients to perform any proposed procedure; or refusal to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6zvmxt	Evaluation of the muscular, neurophysiological and biomechanical structure of the lower limbs of patients with injuries of definition of Neuromuscular electrical stimulation during bicycle intervention- a randomized clinical trial	Not yet recruiting	Intervention	2020-04-03	<NULL>	<NULL>	3705	Morphological and neuromechanical evaluation of the lower limbs of Critical patients to define parameters of Neuromuscular Electrostimulation during intervention with a Cycloergometer- a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-6zvmxt	<NULL>	24 hours of invasive mechanical ventilation; being over 18 years old; present stable clinical conditions	pneumothorax, deep venous thrombosis and pulmonary thromboembolism, noradrenaline prescription, oxygenation index less than 150, recent history of deep venous thrombosis without use of anticoagulants, thrombocytopenia, hemodialysis patients, anasarca, prolonged weaning with failure in at least 3 tests spontaneous ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8dmynv	Effect of an educational video on the promotion of self-care with arteriovenous fistula	Not yet recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3706	Promotion of self-care with the arteriovenous fidtulaa through an educational video: randomized clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8dmynv	<NULL>	Patients with arteriovenous fistula for at least six months; both sexes; age over 18 years.	mental or cognitive disorder that makes it impossible to apply the data collection instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-7hr7ws	Appearance of mouth sores as a side effect of Docetaxel treatment in patients who had cryotherapy	Recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3707	Oral mucositis in Docetaxel-treated patients who had cryotherapy	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital das Clinicas de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7hr7ws	<NULL>	Patients older than 18 years in the first cycle of chemotherapy with docetaxel.	It will be excluded from the study patients with indication or history of radiotherapy treatment; other chemotherapy regimens; active smokers in the last 90 days; patients with cancer lesions affecting the head and neck region; patients with clinically identified oral lesions or infections; patient with active periodontal disease in the immediate pre-Qt; patients who do not complete pre-QT dental preparation; carriers of autoimmune diseases; patients with infectious complications from any site; neurological or psychomotor alterations that hinder self-care, cryotherapy and / or response to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-2mhvwv	Physical exercise at home for older people with Alzheimer&apos;s disease	Recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3708	Home-based physical exercise program for older people with Alzheimer&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal de São Carlos	Larissa Pires de Andrade	https://ensaiosclinicos.gov.br/rg/RBR-2mhvwv	<NULL>	"The eligibility criteria used are elderly aged 65 years and over, not institutionalized and with the possibility of contact via telephone or home address. Inclusion criteria are the ability to walk small distances alone without walking aids (minimum 10 meters); willingness to participate in the proposed evaluations and interventions; present a diagnosis of AD in the mild or moderate phases, according to the Manual of Diagnosis and Statistics of Mental Disorders 4th edition (DSM-4) and the Dementia Evaluation Score (CDR) (MORRIS, 1993); and have a medical certificate, suitable for physical exercise.
For Biodex analysis, the elderly could not have prosthesis, pacemaker, pain at the time of collection and fracture in the last two years in both lower limbs.
For postural control analyzes, the elderly should be able to sit and stand without support"	Exclusion criteria are the existence of motor sequelae due to stroke; presence of neurological disorders that interfere with cognition and / or mobility, such as Parkinson&apos;s disease, Stroke, Multiple Sclerosis, Huntington&apos;s disease, epilepsy and traumatic brain injury; functional or sensory impairments that prevent the application of the proposed tests (limb plegia or paresis, severe tremor and functional impairment of the hands, severe and uncorrected audiovisual disturbance that makes communication difficult during the tests); other types of dementia diagnosed; individuals with advanced AD; any cardiovascular or infectious disease present in the list of absolute contraindications described in the Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aortic aneurysm, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardial infarction, acute myocarditis, acute pulmonary or systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-58m7f6	Comparison between different methods of root canal treatment in children.	Recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3709	Pulpectomy versus non-instrumental endodontic treatment in deciduous teeth: randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-21	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-58m7f6	<NULL>	Posterior teeth with deep caries lesions and associated interradicular and / or periapical radiolucency; teeth affected by caries with abnormal mobility due to periapical pathology, but not associated with physiological exfoliation; history of spontaneous pain; teeth presenting intraoral swelling or drainage of the sinus tract; continuous bleeding after amputation of the coronal pulp tissue; and teeth with external physiological or pathological resorption involving less than a third of the root length.	Systemic pathology (clinically compromising conditions and special health care needs); history of allergic reaction to local anesthetics or to the components of the test materials; antibiotic therapy in the 30 days prior to the intervention or during treatment; teeth unable to receive absolute isolation and / or unable to be restored; tooth that has previously undergone root canal manipulation; tooth with interradicular or periapical radiolucency involving more than half of the smallest vertically measured root; tooth with internal root resorption; tooth with physiological or pathological external root resorption of more than one third of its length; root canal obliteration; or inadequate bone support evidenced by non-physiological tooth mobility compared to the contralateral tooth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-3ccyk2	Analysis of the amount of fat, muscle and bone in older people without dementia and with Alzheimer&apos;s disease.	Recruiting	Observational	2020-04-06	<NULL>	<NULL>	3710	Analysis of body composition in older people preserved cognitively and with Alzheimer&apos;s disease.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3ccyk2	<NULL>	The eligibility criteria are older people aged 54 years old or over, not institutionalized and with the possibility of contacting them by phone or home address. Inclusion criteria are available to participate in the proposed evaluations; present diagnosis of Alzheimer&apos;s disease in the mild or moderate phases, according to the Diagnostic and Statistics Manual for Mental Disorders 4th edition (DSM-4) and the Dementia Assessment Score or be preserved cognitively.	The criteria for exclusion are sensorial or function commitments that affect the application of proposed tests and the presence of neurological diseases that interfere in cognition, such as Parkinson&apos;s disease, stroke, multiple sclerosis, Huntington&apos;s disease, epilepsy, and brain trauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-534wr3	Comparison between scraping followed by cauterization and traditional surgery in the treatment of low-risk skin cancer up to 10 millimeters in size	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3711	Curettage and electrocoagulation VS conventional surgery in the treatment of low-risk basal cell carcinoma up to 10mm in diameter: a randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-534wr3	<NULL>	"Patient at the clinical ambulatory of
Dermatology of the Hospital das Cínicas da FMB-Unesp with diagnosis of low-risk basal cell carcinoma; clinically evident  of up to
10mm in diameter; Sign the informed consent form."	Injury from previous basal cell carcinoma recurrence; Gestation; breastfeeding; Not concordant; Coagulation disorder; Immunosuppression; Difficulty maintaining adequate local care; Difficulty of understanding; Inability to attend outpatient visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-6h8xfn	Effects of grape juice consumption on muscle damage and pain in volleyball athletes	Data analysis completed	Intervention	2020-04-07	<NULL>	<NULL>	3712	Effects of grape juice consumption on oxidative stress and muscle fatigue in volleyball athletes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-30	Centro Universitário Metodista IPA	Centro Universitário Metodista	https://ensaiosclinicos.gov.br/rg/RBR-6h8xfn	<NULL>	Starting players; male; aged between 14 and 20 years; have daily training routines.	Injured athletes who are out of training and / or competing in the past six months, athletes using anti-inflammatory drugs, and athletes who have an aversion or allergy to the components of grape juice will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-5dxg2k	Wear control caused by diet or illness in patients with reflux- clinical study	Not yet recruiting	Intervention	2020-04-07	<NULL>	<NULL>	3713	Control of erosive tooth wear in patients with gastroesophageal reflux disease - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-31	Hospital de Clínicas de Porto Alegre	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5dxg2k	<NULL>	Individuals aged &gt;= 18 years; both sexes; diagnosis of positive gatroesophageal reflux disease; at least one tooth with erosive tooth wear	Individuals with special needs; &lt;18 years; with difficulties in understanding the protocol and its guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-53tx8f	Effect of specialized attention directed to health education in the construction of knowledge about diabetes mellitus	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3714	Effect of specialized attention directed to health education in the construction of knowledge about diabetes mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-53tx8f	<NULL>	Ages 18 years and over, of both sexes; Have a previous diagnosis of type 1 or 2 diabetes mellitus; Being out of balance with your staff in the last year; Be able to perform self-care; Accept to participate in the research by signing the consent form.	Loss of autonomy and independence to perform self-care during the research period; Unjustified absence of one of the intervention activities; Disconnection of CEAE; Individuals who do not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4q5whj	Application of an unsupervised fitness program in cancer patients	Recruitment completed	Intervention	2020-04-07	<NULL>	<NULL>	3715	Application of a Home Based Unsupervised Fitness Program in Cancer Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Centro Universitário Sudoeste Paulista - Itapetininga	associação de portadores de câncer de Itapetininga – SP APCDI	https://ensaiosclinicos.gov.br/rg/RBR-4q5whj	<NULL>	"Individuals aged 18 to 70 years; of both genders; have a diagnosis of cancer without specifying the type of affected person;
these individuals must be or have already completed treatment whether it be chemotherapy or radiation therapy"	Cardiovascular problems, metastasis, acute respiratory problems, cognitive dysfunction and immune deficiency, Explanations about the protocols, objectives, risks of participation and the right to withdraw from the project will be given during the first visit to the patient	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-23j2m8	Dermatological evaluation of  GINOCONFORT	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3716	Dermatological evaluation of the photoirritating and photosensitizing potential_27567	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2020-08-01	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-23j2m8	<NULL>	Male and female participants; Age group between 18 and 70 years; Be in agreement not to change your habits of using health products, including hygiene; Skin intact in the test region; Agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for reading the dressings; Understanding, agreement and signing the Informed Consent Form (ICF).	Pregnancy or risk of pregnancy and / or lactation; (when women); Atopic or allergic background to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as Diabetes, HIV, etc .; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, swimming pool or sauna during the study; Water sports during the study; Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or health products during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the researcher to be reasonable for disqualifying participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-5c2nsh	The influence of playing and games on stress in students of the 6th and 7th year of the public school	Recruitment completed	Intervention	2020-04-08	<NULL>	<NULL>	3717	The influence of Playing and Traditional Games on Perceived Stress in students of the 6th and 7th year of the public school	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Federal de São Paulo	Escola Municipal de Ensino Fundamental Matteo Bei	https://ensaiosclinicos.gov.br/rg/RBR-5c2nsh	<NULL>	Students aged between 11 and 14 years old, enrolled in the 6th and 7th years of &quot;Matteo Bei&quot; public school	Students that do not attended all of the data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-2xzzsj	Effect of realistic simulation on knowledge, satisfaction and self-confidence of nursing technical students	Recruitment completed	Intervention	2020-04-08	<NULL>	<NULL>	3718	Knowledge, satisfaction and self-confidence of nursing technical students from the use of realistic simulation: quasi-experimental study	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2xzzsj	<NULL>	Students of the technical nursing course of the institution selected for the research	Students with professional experience in healthcare	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-68mmbp	Pain relief strategies at the insertion of Mirena in young women	Data analysis completed	Intervention	2020-04-08	<NULL>	<NULL>	3719	Pain relief strategies at the insertion of the levonorgestrel releasing intrauterine system in young women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Medicina-Universidade Federal de Minas Gerais	Faculdade de Medicina-Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-68mmbp	<NULL>	The study included 100 healthy nulligravous women, aged 15-24 years, with indications for use of SIU-LNG (contraception, discontinuation of menstruation, control of menorrhagia, dysmenorrhea, etc.).	The study excluded patients with: hysterometry less than 5 cm; cytological changes in cytology of the last eighteen months; known distortion of the uterine cavity (e.g., by submucosal fibroids); contraindications to the use of progestins; recent history of pelvic inflammatory disease or untreated genitourinary tract infection; abnormal uterine bleeding of unknown cause; less than 6 weeks postpartum or postabortion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8nxwps	Effect of Omega-3 in Obese pregnant women on bad pregnancy outcomes	Recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3720	Effect of Omega-3 in Obese pregnant women on unfavorable pregnancy outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade da Região de Joinville - UNIVILLE	Maternidade Darcy Vargas	https://ensaiosclinicos.gov.br/rg/RBR-8nxwps	<NULL>	Pregnant women diagnosed with obesity will be selected according to World Health Organization criteria with a BMI greater than or equal to 30 kg / m2, aged 18 years or over, single pregnancy, with negative screening for gestational diabetes mellitus (GDM) at the beginning of pregnancy, gestational age less than 20 weeks, without pathology that interferes with glucose metabolism, coagulation disorder, systemic arterial hypertension (SAH), history or presence of liver, kidney or gastrointestinal disease or other condition that interferes with absorption, distribution and excretion of omega-3.	Pregnant women who wish to do so and those who are at risk for the fetus will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-3dv5t8	Comparative study between the effectiveness of Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser devices in the scar incision in post-cesarean pain	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3721	Comparative study between Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser in post-cesarean section pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3dv5t8	<NULL>	Postpartum women residing in Patos de Minas - MG, who are in the immediate puerperium (3 to 10 days postpartum), with pain at the incision site, with spinal anesthesia before the surgical procedure, absence of pathology will be included in the study genitourinary.	Patients with changes in sensitivity, demyelinating diseases, spinal cord trauma, hemorrhage, infection, fever, anesthetic complications, arterial hypertension will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-72f23t	Comparison between comic book and verbal information about surgery in the anxiety of parents and children in the preoperative period	Recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3722	Educational intervention through a comic book on anxiety of parents and children in the preoperative period: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Faculdade de Medicina de Botucatu - Departamento de Enfermagem	Faculdade de Medicina de Botucatu - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-72f23t	<NULL>	"CChildren
Children aged 6 to 14 years. Physical status ASA I and II according to the classification of the American Society of Anesthesiologists (ASA). With elective surgery scheduled for up to 04 hours in duration.

Parents: be 18 years or older. Be literate and communicate verbally."	"Children
Children with neuropsychomotor deficit and using psychoactive drugs. With hearing and / or visual impairment. Using pre-anesthetic medication. Hospital stay longer than 07 days.
Parents
Exclusion Criteria: Not having accompanied the child since admission to the operating room."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-67hbwn	Regular application of Fluoride Gel in the treatment of Incipient Carious Lesions	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	3723	Regular application of Fluoride Gel in the treatment of Incipient Carious Lesions: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Universidade Federal de Santa Maria/ Pró-Reitoria de Pós-Graduação	Universidade Federal de Santa Maria- UFSM	https://ensaiosclinicos.gov.br/rg/RBR-67hbwn	<NULL>	Healthy schoolchildren; age between 6 and 18 years, both genders; presence of at least one non-cavitated active lesion on any surface of any permanent tooth.	Students with fixed orthodontic appliances; schoolchildren with special needs; schoolchildren with cognitive difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-9pgwfc	Psychological effects of social isolation in the coronavirus pandemic	Recruiting	Observational	2020-04-09	<NULL>	<NULL>	3724	Psychological effects of preventive isolation in the COVID-19 pandemic	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-04-07	Hospital Universitário Bettina Ferro de Souza	Hospital Universitário Bettina Ferro de Souza	https://ensaiosclinicos.gov.br/rg/RBR-9pgwfc	<NULL>	Healthy volunteers; both genders; age between 18 and 90 years.	People under the age of 18.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-9vqsdx	Effects of resistance training on blood pressure and other cardiovascular risk factors in hypertensive women	Recruitment completed	Intervention	2020-04-09	<NULL>	<NULL>	3725	Acute and chronic effects of different types of resistance training on blood pressure and other cardiovascular risk factors in hypertensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9vqsdx	<NULL>	Hypertensive women over the age of 45, enrollment and multidisciplinary treatment at the Hypertension League of Hospital das Clínicas, Federal University of Goiás in a minimum period of six months; not participating in exercise programs for minimum of twelve months; controlled and stable blood pressure with no change in medication in a previous minimum period of six months; able to practice regular physical exercise.	Recent myocardial infarction for less than six months; recent stroke; congestive heart failure; chronic renal failure; decompensated diabetes, untreated and severely neuromuscular, musculoskeletal or joint diseases and any other disease or limitation that could compromise the performance of physical exercise protocols; Body mass index greater than 30 kilograms per meter squared; appearance of arrhythmias and or ischemic changes identified in the cardiovascular test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4hyp7w	Comparison of respiratory, hemodynamic and metabolic effects between two surgical techniques for the treatment of excessive sweating	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3726	Respiratory, hemodynamic and metabolic effects during thoracic sympathectomy comparing the surgical techniques apneic and carbon dioxide insufflation	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de SAão Paulo	Hospital Estadual de Diadema	https://ensaiosclinicos.gov.br/rg/RBR-4hyp7w	<NULL>	"Age between 18 and 40 years.
ASA 1 and 2.
Ability to understand the scales for assessing pain intensity and performing spirometry."	"Previous respiratory diseases (both obstructive and restrictive).
History of upper airway infection in the last 2 months prior to surgery.
Smoking.
Severe heart disease (NYHA class III or IV, acute coronary syndrome or tachyarrhythmias).
Insulin-dependent diabetes mellitus.
Obese morbid.
Use of illicit drugs.
Pregnancy.
Previous lung surgery.
Mechanical ventilation in the last 30 days.
Contraindication for total intravenous anesthesia.
Refusal of the patient to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-9ktwx6	Effect of the use of Chloroquine and Hydroxychloroquine as a possible protector for Infection with the New Corona Virus 2019 in patients with Rheumatic Diseases	Recruiting	Observational	2020-04-09	<NULL>	<NULL>	3727	Evaluation of the effect of chronic use of Antimalarials on the frequency of infection with the New Corona Virus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 - SARS-CoV-2) in patients with Immunomedical Rheumatic Diseases	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	Socidade Brasileira de Reumatologia	Departamento de Ciência e Tecnologia - Decit	https://ensaiosclinicos.gov.br/rg/RBR-9ktwx6	<NULL>	Age greater than or equal to 18 years; use of antimalarial drugs for at least 30 days before inclusion; diagnosis of immune mediated rheumatic disease defined according to American College of Rheumatology (ACR) or European League against Rheumatism (EULAR) criteria: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE, Sjogren&apos;s syndrome (SS), systemic sclerosis, myopathies inflammatory diseases, mixed connective tissue disease (DMTC), systemic sclerosis (ES); diagnosis of osteoarthritis (OA) of hands (subgroup).	Previous use of antimalarial, but not current in the last 6 months; history of solid organ or bone marrow transplantation; neoplasm of solid organs or lymphatic or myeloproliferative lineage in the last 12 months with or without adjuvant chemotherapy; use of intravenous human immunoglobulin in the last 30 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8syq77	Effect of the combination of vaginal cones to the training of the muscles of the intimate region on urine loss in postmenopausal women who do or do not use hormones for menopause	Recruiting	Intervention	2020-04-09	<NULL>	<NULL>	3728	Effect of adding vaginal cones to pelvic floor muscle training on urinary incontinence in postmenopausal women who are on or off hormone replacement therapy - randomized controlled trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade do Estado de Santa Catarina	Thuane Huyer da Roza	https://ensaiosclinicos.gov.br/rg/RBR-8syq77	<NULL>	Have been in the postmenopausal period for at least 1 year; between 45 and 60 years of age; have symptoms of urinary incontinence; use hormone replacement therapy for at least 6 months or not use hormone replacement therapy for at least 3 months.	Have any associated urogynecological disease (gynecological cancer and lower urinary tract infection); undergo gynecological surgery; undergo or have undergone other physical therapy treatment for UI; musculoskeletal changes that may prevent the performance of the proposed activities; not being able to contract PFM; have genital prolapses greater than grade 2 and use of mirena / hormonal IUDs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-6v7j88	Workout with Elastics for People with Down Syndrome	Recruiting	Intervention	2020-04-09	<NULL>	<NULL>	3729	Acute and Chronic Effects of Strength Training with Elastic Resistance on Oxidative Stress in People with Down Syndrome (DS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-15	Universidade Católica de Brasília	Secretaria de Estado de Educação do DF	https://ensaiosclinicos.gov.br/rg/RBR-6v7j88	<NULL>	The inclusion criteria to be part of the intervention group are have a diagnosis of Down Syndrome; have listening and listening comprehension (so that you can understand and respond to commands); be between 20 and 50 years old; have medical clearance for physical activity. To be part of the control group the inclusion criteria are be a teacher at Centro de Ensino Especial  01 in Samambaia; be between 20 and 50 years old; have medical clearance for physical activity.	The exclusion criteria will be the same for both the intervention group and the control group. This study will exclude participants who present any contraindications to strength training, or physical limitations for the practice of physical exercises, such as, for example, musculoskeletal problems that prevent them from performing the exercises proposed in the study;  participants who present any cardiological changes that prevent them from exercising; have other associated pathologies like cerebral palsy, and or autism; refuse to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8g2bc8	Influence of periodontal treatment on microbiological, blood and salivary levels of Rankl, Survivin and Osteoprotegenin biomarkers in individuals with rheumatoid arthritis	Recruitment completed	Intervention	2020-04-09	<NULL>	<NULL>	3730	Periodontal disease and rheumatic diseases: evaluation of clinical, immunological, genetic and microbiological associations. Subproject: rheumatoid arthritis and periodontal disease: association between periodontal treatment, oral microbiome and therapy with disease course modifiers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8g2bc8	<NULL>	Volunteers with Rheumatoid Arthritis; both genders, aged 35 to 65 years; minimum period of 6 months from the last periodontal treatment; no use of antimicrobials in the period of 3 months prior to the study.	Volunteers diagnosed with other rheumatological diseases; diabetics; pregnant women; volunteers with disabling psychological or physical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-36bxjx	Comparison of two anesthetic gels at maxillary posterior teeth extraction.	Recruitment completed	Intervention	2016-12-05	<NULL>	<NULL>	3731	Comparison of anesthetic efficacy between two gels in extraction of upper molars : a randomized clinical trial.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2015-11-25	Universidade Federal de Sergipe	Faculdade de Odontologia de Piracicaba- Universidade de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-36bxjx	<NULL>	Individuals treated at the Department of Dentistry, Federal University of Sergipe ; of both genders; in the age range 18-60 Years of Age; sign an Informed Consent Form; Need of bilateral upper molars extraction	History of allergy or other problems arising from the use of any components of the formulations to be employed; History of methemoglobinemia; Alcoholics and toxic users; Fear of dentist; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4v6h7b	Effect of different types of physical exercise on cardiometabolic factors in overweight adolescents	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3732	Effect of aerobic training and high intensity interval training (HIIT) on cardiometabolic factors in overweight adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Prefeitura Municipal de Curitiba	Friends of the Clinical Hospital	https://ensaiosclinicos.gov.br/rg/RBR-4v6h7b	<NULL>	Overweight adolescents; of both sexes; aged between 10 and 17 years; stable weight over a period greater than or equal to 2 months; height greater than 1.45 m, depending on the height of the bicycle seat; not using anorectic drugs or others that could interfere with weight control and controlled hyperinsulinemia and hypothyroidism; be regularly enrolled in school; present the Free and Informed Consent Form signed by the parents or guardians	Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; not participating in the second physical evaluation of the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-7w4cp9	Effectiveness of Osteopathy in Patients with Knee Pain	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	3733	Effects of Osteopathic Manipulative Treatment on Patellofemoral Pain Syndrome of Runners Athletes: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Ceilândia	Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-7w4cp9	<NULL>	Athlete practicing running; between 18 and 35 years.	Cognitive, musculoskeletal or psychiatric disorders; uncontrolled diabetes mellitus; history of recent infection (last 03 months); use of corticosteroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-946wmb	Effects of osteopathy on pulmonary function in healthy	Data analysis completed	Intervention	2018-09-03	<NULL>	<NULL>	3734	Effects of Osteopathic Manipulative Treatment on the cardiovascular and respiratory systems of healthy youngsters	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Fundação Universidade de Brasilia	Fundação Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-946wmb	<NULL>	Healthy subjects; adults; male	Previous respiratory disease; ribcage deformity; respiratory infection in the past three months; caffeine previous evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4jrbdk	Evaluation of the effect of Pycnogenol® and Tranexamic Acid in the treatment of facial stains	Recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3735	Pycnogenol® versus oral tranexamic acid in the treatment of facial melasma in women: a double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-22	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB - Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-4jrbdk	<NULL>	Women between the ages of 18 and 60 with facial melasma; without treatment for at least 60 days; except for the use of sunscreen.	Patients with concomitant facial dermatoses; photosensitivity dermatoses;  collagenosis; blood dyscrasias and / or under the use of anticoagulant medication; history of thrombosis; immunosuppressed patients will be excluded; pregnant; lactating women. Phenotypic extremes will be excluded: red and black because melasma is rarely mentioned in these groups. Obese; smokers; personal history of abortion; sedentary; with personal or family history of previous thrombotic event (pulmonary thromboembolism or deep vein thrombosis) are at greater risk of thromboembolism and, therefore, contraindication to the use of oral tranexamic acid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6r7w8k	Study of the cost effectiveness of flour of passion fruit and turmeric on Diabetes	Data analysis completed	Intervention	2020-04-13	<NULL>	<NULL>	3736	Analysis of the effectiveness and cost-effectiveness of two interventions for the glycemic and lipemic control of people with Diabetes: intervention with the Flour of the Passion Fruit Peel and with the Turmeric	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-26	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6r7w8k	<NULL>	patients diagnosed with type 2 diabetes for at least one year; patients aged 18 years or older	patients using insulin; patients using medications such as glucocorticoids, psychotropic or antineoplastic agents; pregnant patients; patients with some type of immunosuppression; patients with complications of type 2 diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-4c249m	Telephone monitoring of surgical patients	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3737	Effectiveness of telephone follow-up on surgical recovery of surgical patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal Fluminense	Hospital Federal dos Servidores	https://ensaiosclinicos.gov.br/rg/RBR-4c249m	<NULL>	"Elderly patients aged 60 years and over, coming from of the surgery service of the Hospital Universitário Antônio Pedro e Hospital Federal de Servidores do Estado in the preoperative period of hernia repair and laparoscopic cholecystectomy.
Own cell phone or landline
available for contact by the nurse."	"Patients diagnosed with dementia; patients with hearing deficit without a companion who can receive interventions by phone; patients
undergoing  surgery to treat previous surgical complications."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-5zrzg4	Comparison of water exercises for children with cerebral palsy to improve their walking	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3738	Comparison of aquatic intervention protocols and its repercussion in the gait of children with cerebral palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-02	Associação de Assistência a Criança Deficiente	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5zrzg4	<NULL>	Children with spastic diparesis type of Cerebral Palsy;classified as level II and III on GMFCS; with age between 6 years and 8 years and 11 months will be included.	It will be excluded children that does not cooperate; unable to understand the proposed activities;submitted to orthopedic surgeries at less than 12 months; and peripheral blocks for less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6hhmdz	Effect of Pear Orange and Blood Orange Juices on inflammation and antioxidant activity in individuals with pre-diabetes	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3739	Effect of Orange and Blood Orange Juices on the plasma biochemical parametes, functional capacity of monocytes, inflammatory and oxidative stress biomarkers, on individuals diagnosed with insuline resistance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Faculdade de Ciências Farmacêuticas	Fundo de Defesa da Citricultura	https://ensaiosclinicos.gov.br/rg/RBR-6hhmdz	<NULL>	Age between 40 and 60 years, both genders, with nutritional diagnosis of obesity according to the World Health Organization classification (2000) and with diagnosis of insulin resistance according to the HOMA-IR index.	Inflammatory diseases in the gastrointestinal tract, use of supplements or antibiotics and inability to respond to research questionnaires or to perform nutritional status assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-89hswb	Evaluation of the effectiveness of resistance exercise in the elderly living in a long-term care facility	Recruiting	Intervention	2020-04-13	<NULL>	<NULL>	3740	Evaluation of Effectiveness of a Progressive Resistant Training program in eldery residentes in long-term state institution	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-19	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-89hswb	<NULL>	Individuals aged over 60 years old, both sexes, capable of walking without the aid of walking devices, living in a long-term care facility for elderly people (ILPI) and who agree to participate in the study by signing the Informed Consent Form.	Individuals with psychiatric problems diagnosed by medication use or medical report, disability wheelchair use, hypertension not controlled by medication, cognitive impairment and severely limiting visual or hearing deficit not compensated by wearing glasses and hearing aids will be excluded. of sound amplification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-23mbf7	Effects of detraining on the quality of life of elderly people practicing resistance training in water compared to traditional water aerobics training	Data analysis completed	Intervention	2020-04-13	<NULL>	<NULL>	3741	Effects of detraining on the quality of life of elderly people practicing resistance training in water	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23mbf7	<NULL>	"ge equal or superior to 60 years;
Do not present psychiatric and / or neurological disorder (apparent or diagnosed);
Be able to practice physical activity, proven by a medical certificate brought by the patient; have participated in the hydro gymnastics program in the last six months."	the elderly who were unable to visually recognize digits; were affected by any disabling illness that did not allow them to be physically active; having been injured during the program; have been absent from the Hydrogynas program for more than 5 consecutive days; and been participating in any other regular physical activity program in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7jwxqd	Changes in the energy channels of Acupuncture in patients with Spinal Cord Injury, and possible correlations with the ASIA Neurological Assessment Scale	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3742	Energy Profile with Ryodoraku Acupuncture Electrodiagnosis in patients with Spinal Cord Injury and possible correlations with the ASIA Scale	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-31	Faculdade de Tecnologia IBRATE	Faculdade de Tecnologia IBRATE	https://ensaiosclinicos.gov.br/rg/RBR-7jwxqd	<NULL>	Participants were recruited from patients who attended the neurological physiotherapy service at hospital da universidade estadual de londrina . The inclusion criterion was to present spinal cord injury of the spastic or flaccid paraplegia type, older than 18 years of age, not to have lesions or dermatological changes in the wrist and ankle regions (places of inspection of the technique). Both sexes; races; religion and color were included.	To have a pacemaker. Individuals with quadriplegia and paraparesis; pregnant women were exclude	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-3wvq7b	Analysis of the short-term effects of the Schultz relaxation technique on the response of the Autonomic Nervous System induced by anxiety medications	Recruiting	Intervention	2020-04-13	<NULL>	<NULL>	3743	Analysis of the acute effects of the Schultz technique on the response of the Nervous System Autonomic induced by anxiolytics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Escola Paulista de Medicina- UNIFESP	UNESP - Faculdade de Filosofia e Ciências - Câmpus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-3wvq7b	<NULL>	Volunteers with anxiety disorder; taking anxiety medication; nonsmokers; age between 18 and 30.	Volunteers with reported cardiorespiratory and / or endocrine disorders; individuals using drugs that alter cardiac autonomic regulation; smokers; women between 11th to 15th or 21st to 25th day after the first day of the last menstrual cycle; those who drank alcohol or caffeine 24 hours before collection and those with a BMI above 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7ph66k	Effects of a program of behavior change for Primary Health Care workers	Recruitment completed	Intervention	2020-04-13	<NULL>	<NULL>	3744	Effects of a behavior change program for a healthy lifestyle of primary health care workers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7ph66k	<NULL>	Primary health care professionals; Age between 18 and 60 years old.	Do not participate in 85% of the meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8969zg	Treatment of 2019-nCoV Pneumonia with N-acetylcysteine	Not yet recruiting	Intervention	2020-04-13	<NULL>	<NULL>	3745	Clinical Trial using N-acetylcysteine for treatment of 2019-nCoV Pneumonia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-14	Universidade de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8969zg	<NULL>	Volunteers; Both genders; Admitted to the Emergency Department with diagnosis of Acute Respiratory Syndrome, presumed or confirmed; Age equal to or greater than 18 years; Informed consent form (ICF) signed by the patient or legal guardian.	Patients with known allergy to N acetylcysteine; Pregnant women; In need of immediate mechanical ventilation or Refusal or inability to obtain consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8pqp4q	Effects of meditation practice on stress reduction in teachers	Recruitment completed	Intervention	2020-04-14	<NULL>	<NULL>	3746	Randomized Controlled Trial of the effects of meditation practice on stress reduction in teachers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8pqp4q	<NULL>	To be an active teacher of Ensino Fundamental II at São Paulo City	Under 21 years old and over 65 years old; Uncontrolled chronic diseases; regular meditation practice and similar techniques, such as yoga and tai chi chuan; use of prescription drugs without medical supervision; presence of sleep disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7kfwfv	Disinfection efficacy of diode laser in root canal retreatment: a clinical trial with follow up	Data analysis completed	Intervention	2020-04-14	<NULL>	<NULL>	3747	Antimicrobial efficacy of 980 nm diode laser in root canal indicated to retreatment: a randomized trial with clinical and radiographic follow up	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7kfwfv	<NULL>	unirradicular tooth with periapical lesion 2 years; healthy patients	Patients with fractured teeth; perforation; root resorption; pregnant women and have received antimicrobial treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-422bdd	Laser for healing Nipple Injuries	Not yet recruiting	Intervention	2020-04-16	<NULL>	<NULL>	3748	Low Power Laser for Healing Fissures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-422bdd	<NULL>	Women who are breastfeeding and have nipple cracks.	Women under 18; who are undergoing any treatment for breast fissures; who have neoplasms, pregnancy, cognitive difficulties, infected open wounds and skin with altered sensitivity, who refuse to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8mgdwm	Study of the effect of local Infiltration in comparison with intramuscular Infiltration in the treatment of Trigger finger	Data analysis completed	Intervention	2020-04-16	<NULL>	<NULL>	3749	&quot;Local versus systemic infiltration for the treatment of trigger finger: randomized clinical trial - PHASE 3 study&quot;	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-04-12	Hospital Alvorada Moema	Hospital Alvorada Moema	https://ensaiosclinicos.gov.br/rg/RBR-8mgdwm	<NULL>	"Patients over 18 years of age, with trigger finger grade II and grade III of the Green Classification will be submitted to clinical evaluation, in which we will consider three criteria for diagnosis:

Clinical history: pain at A1 pulley level, history of bounce and / or active or passive block, exacerbation of symptoms in the morning;

Physical examination: presence of pain in pulley A1, with or without shoulder or block;

USG: presence of tenosynovitis, with or without tendon nodule. The presence of two of the three criteria will be sufficient for diagnosis and inclusion. There will be no intervention by researchers with regard to the inclusion of patients, with the aim of controlling potential inclusion bias.
After reading, explaining the study proposal and accepting to participate, all research subjects will sign a Free and Informed Consent Form (ICF)"	"Anterior surgical treatment of trigger finger;
Hypersensitivity to the corticosteroid;
Refusal of the consent term"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-229scm	Techniques for Infant Feeding initiation: A Randomized Controlled Trial	Recruiting	Intervention	2019-09-24	<NULL>	<NULL>	3750	Methods of Complementary Feeding Introduction in Children: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Hospital de Clínicas de Porto Alegre	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-229scm	<NULL>	Mothers residing in Porto Alegre and metropolitan area; with full-term children; with birth weight greater than or equal to 2500g; healthy; which have not yet begun to introduce complementary feeding; whose age range is between zero and 4 months of age.	Children who during follow-up presented a weight-to-height growth deficit; who have any type of food restriction indicated by their doctor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6z8qqy	Effects of a Cereal Bar source of vegetable Estrogen on the symptoms of Menopausal women	Recruitment completed	Intervention	2020-04-17	<NULL>	<NULL>	3751	Development of a Cereal Bar source of Phytoestrogen and effects on the syntomatology of Climate women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-25	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-6z8qqy	<NULL>	Climacteric women with symptoms assessed using the Kupperman Index.	Use of hormone replacement therapy; consumption of supplements with some type of phytoestrogen; consumption of hypolipidemic or hypoglycemic agents; frequent consumption of alcoholic beverages; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9d2hbm	Evaluation of Surgical Treatment of Disease involving Dental Implants	Recruiting	Intervention	2020-04-20	<NULL>	<NULL>	3752	Evaluation of Surgical treatment of peri-implantitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Universidade Federal do Rio Grande do Norte	Universidade Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-9d2hbm	<NULL>	Volunteers of both sexes; age over 18 years; toothless units, partial or total; patients with single or multiple osseointegrated implants rehabilitated with a minimum period of 12 months; patients with at least one implant with the clinical diagnosis of peri-implantitis according to the criteria of Mombelli (1999).	Volunteers with severe psychosomatic illnesses that prevent good oral hygiene; diagnosis of systemic conditions that make it impossible to undergo a surgical procedure; hallucinogenic or narcotic drug users; history of antibiotic and / or anti-inflammatory therapy 3 months before the initial evaluation visit; carriers of diseases that cause severe impairment of the immune system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7b5x5k	Use of Magnesium Sulfate to control postoperative pain in patients undergoing uterus removal surgery	Recruitment completed	Intervention	2020-04-20	<NULL>	<NULL>	3753	Use of Magnesium Sulfate as an adjunct to postoperative analgesia in patients undergoing non-oncologic Abdominal Hysterectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-10	Hospital Geral de Cuiabá	Hospital Geral de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-7b5x5k	<NULL>	Women under the age of 65; classified in Physical State I to III of the American Society of Anesthesiology; who are candidates for non-oncologic abdominal hysterectomy	Age under 18 years; body mass index less than 40; renal dysfunction; neuropathy or myopathy; known hypersensitivity to magnesium sulfate or to drugs used according to the protocol; previous treatment with calcium channel blockers; all types of heart block; opiate addiction; patient&apos;s refusal to participate in the study; contraindication to spinal anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9bjttc	Effect of electrical stimulation applied to the skull on response time and cognition of soccer players	Not yet recruiting	Intervention	2020-04-20	<NULL>	<NULL>	3754	Effect of Transcranial Direct Current Stimulation on Cognition and Reaction Time of soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-9bjttc	<NULL>	Individuals of 18-30 years of age; male; right-handed and left-handed; with no associated comorbidities such as orthopedic neurological and visual problems	metal-in-cranium; injuries near the electrode placement area; cardiac pacemaker in situ; intracerebral vascular clips; epilepsy; severe cognitive impairment; previous visual disturbances; depression with scores more than 8 in the Hospital Anxiety and Depression Scale (HAD).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7pzcyk	Stress reduction, meditation and mindfulness program in patients with chronic Heart failure	Recruitment completed	Intervention	2020-04-20	<NULL>	<NULL>	3755	Impact of Stress reduction, meditation and mindfulness program in perceived stress of patients with chronic Heart failure: randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-31	Universidade Federal Fluminense	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-7pzcyk	<NULL>	HF NYHA class I or II; literate,  owners of an audio device for listening the meditation CD; committed adhering to 8 weeks of the program; with Mini Mental score beyond 16	Concomitant participation in another study or therapy involving mind body or drug intervention in the last month; Recent clinical decompensation with hospitalization or changes in medication prescription for HF in the last month; Surgery or percutaneous intervention planned for the next year; Presence of acute coronary syndrome or acute myocardial infarction within the last 2 months; Clinically significant valve disease; Acute myocarditis; Musculoskeletal diseases that prevented functional tests such as the 6 minute walk test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8rz2yb	Impact of inspiratory muscle training on the performance of futsal athletes	Recruitment completed	Intervention	2017-01-26	<NULL>	<NULL>	3756	Impact of inspiratory muscle training on the aerobic performance of futsal athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Centro Universitário Serra dos Órgãos	Centro Universitário Serra dos Órgãos	https://ensaiosclinicos.gov.br/rg/RBR-8rz2yb	<NULL>	All athletes practicing indoor football in Rabelo in Comary team; male; between 14 and 30 years.	Volunteers with cardiopulmonary disease; muscle or bone-joint injuries to any degree in the last two months and six months respectively; overweight; cognitive inability to achieve the proposed protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6g8n92	Evaluation of the effects of Respiratory Training in patients with Sickle Cell Disease	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3757	Evaluation of the effects of Inspiratory Muscle Training in patients Sickle Cell Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-03	Hemocentro - Universidade Estadual de Campinas	Hemocentro - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6g8n92	<NULL>	Have a diagnosis of sickle cell disease; of both genders; be between 18 and 70 years old; present a stable clinical condition of the disease.	Present neurological or traumatic sequelae that make it impossible to properly perform any of the assessment items; presenting neurological or traumatic sequelae that make it impossible to properly perform inspiratory muscle training; present any lung disease that is not related to sickle cell disease and that may alter the appropriate performance of any of the assessment items.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9cb7b7	Immediate effect of Aerobic, Resistence and Competitor Training on Elderly Memory	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3758	Acute Effect of Aerobic, Resistence and Competitor Training on Elderly Memory	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-04	Nathalia Griebler	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9cb7b7	<NULL>	"Age between 65 and 75 years old;
Present physical conditions to perform the exercise protocol;
Not performing any regular physical activity for at least three months;
Achieve a score of 24 or higher in the Mini Mental State Exam
Achieve a score of up to 9.11 on the Baecke Physical Activity Questionnaire (cutoff point adopted for low daily physical activity intensity)."	Use antidepressants, antiepileptics, anticonvulsants, psychoactive drugs or other CNS medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-658khm	"Telemedicine in the Covid-19 pandemic in Brazil
in a medical clinic in the supplementary health sector in São Paulo, Brazil"	Recruiting	Intervention	2020-04-22	<NULL>	<NULL>	3759	"Evaluation of patients treated by telemedicine in the Covid-19 pandemic in Brazil
in a medical clinic in the supplementary health sector in São Paulo, Brazil"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Centro Medico Mazzei	Centro Medico Mazzei	https://ensaiosclinicos.gov.br/rg/RBR-658khm	<NULL>	Patients with clinical and epidemiological diagnosis of covid-19 with moderate condition and possible poor prognosis without comorbidities that prevent home treatment.	"Do not sign the informed consent form.
Present previous heart disease / arrhythmia or associated comorbidity that requires hospital follow-up."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-978gy8	Effect of oral Whey protein and Vitamin C supplementation on markers of nutritional status, inflammation, oxidative stress and quality of life: randomized clinical trial in patients undergoing Hemodialysis	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3760	Effect of oral supplementation of Whey proteins and Ascorbic acid on markers of nutritional status, inflammatory methods, oxidative stress and quality of life: randomized clinical test in Hemodialysis patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-978gy8	<NULL>	Be 19 years of age or over; have a diagnosis of CKD; perform HD three times a week in a period of two months and sign the Informed Consent Form	Make use of antioxidants like Vitamin C or E; amino acids; protein or ketoacid supplements, or immunosuppressive drugs within 2 months prior to enrollment or who had an infection or hospitalization in the month prior to the start of the study. Being a carrier of the acquired immunodeficiency virus (HIV); to present a diagnosis of cancer; advanced heart failure, chronic lung disease; liver disease; metal parts in the body like cardiac stimulators, stents, metal dots; have atrophied or amputated limbs; to be hospitalized; being pregnant or breastfeeding; have sequelae that prevent the measurement of parameters and have no ability to understand or communicate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-494fyn	Low level laser therapy and magnetotherapy as coadjuvant in bisphosphonate related osteonecrosis of the jaws.	Recruiting	Intervention	2020-04-22	<NULL>	<NULL>	3761	Randomized controlled trial of Low level laser therapy and magnetotherapy as coadjuvant in Bisphosphonate related osteonecrosis of the jaws treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-26	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-494fyn	<NULL>	"Consent to participate in the study through a Free and Informed Consent Form signed by the patient, female, 60 years of age or older, using oral Alendronate sodium, with weekly doses of 70mg for at least 2 years. continuously for the prevention and or treatment of osteopenia or osteoporosis.
Presence of jaw osteonecrosis, in stages 1 or 2, according to the AAOMS classification. Patients who have previously undergone oral cavity surgical procedures, such as dental extractions or implants, performed no more than 6 months prior to the occurrence of osteonecrosis."	"Presence of jaw osteonecrosis at stage 0 or 3, according to AAOMS.
Presence of spontaneous osteonecrosis in the jaws.
Pathological fractures by osteonecrosis.
Use of alendronate for less than two years or discontinued.
Need to use synthesis material (plate and screws).
Indication of the use of alendronate sodium due to malignant neoplasms, bone metastases, Paget&apos;s disease or any indication other than osteoporosis or osteopenia.
Patients undergoing head and neck radiotherapy in the last 5 years.
Patients undergoing hyperbaric chamber sessions in the last 2 years.
Patients with blood dyscrasias, renal failure, liver failure, cardio respiratory failure, immune deficiency, malignant neoplasms, AIDS or septicemia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9zjgqm	Acute effect of ginger tea (Zingiber officinale) intake on energy metabolism, satiety sensation and prospective food intake	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3762	"Effect of allegedly thermogenic tea intake on metabolism energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9zjgqm	<NULL>	Healthy volunteers; both genders; individuals with stable weight; non smokers; who do not use dietary supplements or medications that can interfere with the results of the study; aged between 18 and 40 years	Hypertensive; diabetic; carriers of diseases that affect energy metabolismo; allergic or sensitive to standard breakfast ingredients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-5ftg3z	Effect of acute ingestion of cinnamon (Cinnamomum zeylanicum) tea on energy metabolism, satiety sensation and food intake	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3763	"Effect of allegedly thermogenic tea intake on metabolism
energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5ftg3z	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 40 years; with stable weight; who do not use dietary supplements or medications that may interfere with the results of the study	Hypertensive; diabetic; carriers of diseases that affect energy metabolism; allergic or sensitive to standard breakfast ingredients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9s6tc8	A short course on Mindfulness via mobile app to reduce Stress and Anxiety in university students	Not yet recruiting	Intervention	2020-04-22	<NULL>	<NULL>	3764	A brief Mindfulness intervention with mobile App for reducing Stress and Anxiety in university students: Protocol for randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-9s6tc8	<NULL>	Volunteers of both genders between eighteen and thirty five years old; being a university student; reside in Brazil; have internet access and a cell phone with Android; be willing to download and use the Neurosaúde application on your cell phone; achieve a score greater than 0 in the symptoms of anxiety and stress measured by the subscales of stress and anxiety of the Depression, Anxiety and Stress Scale.	Volunteers who have already adopted a frequent practice of mindfulness in the past six months; who are using some type of psychotropic medication or undergoing psychological treatment during the intervention period; have a diagnosis of psychiatric or neurological illness, such as schizophrenia, borderline, panic disorder, post-traumatic stress disorder; have severe or extremely severe symptoms of depression as measured by the depression subscale of the Depression, Anxiety and Stress Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-2j26pk	Clinical Study to Assess Anticellulite Efficacy	Not yet recruiting	Observational	2020-04-22	<NULL>	<NULL>	3765	"Clinical Study for Dermatological Evaluation of
Anti-cellulite Acceptability and Effectiveness"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Malwee Malhas Ltda,	Malwee Malhas Ltda,	https://ensaiosclinicos.gov.br/rg/RBR-2j26pk	<NULL>	"Age from 18 to 45 years; Women; Healthy participants (evaluated by the dermatologist); Phototypes I to IV (according to the Fitzpatrick classification), due to the study of acceptability and the
possibility of quickly detecting skin reactions with this scale; Presence of cellulite in the experimental region (buttocks and thighs); Presence of grade I, II, III and IV cellulite; Participants who accept not to change the normal daily routine of their cosmetic habits, except for the use of topical products with activity similar to the test product during the entire study, these do not
must be used; The Informed Consent Form (ICF) has been clarified and signed; Participants who want to participate in the study without financial profit. They will be reimbursed for expenses related to the test, such as transportation and food, among others; Participants who have not participated in similar studies for at least 2 months prior
to study; Regular / occasional users of cosmetic products similar to the product under investigation; Participants who declared they were not at risk of pregnancy during the survey period"	"Allergy to the tested product category; Pregnancy or lactation; Immunodeficiencies; Active atopic dermatitis; Kidney, heart or liver transplantation; Use of the following medications: corticosteroids, antihistamines, immunosuppressants, retinoids, anti-inflammatories; Any condition that may interfere with the evaluations according to the Investigator of the study; Participants who refuse to participate in the study in question.
Note: the participants included are instructed not to change their diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products of the same product category
tested in the experimental region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8kjtps	Educational intervention to promote a positive reaction to the adversities of adolescents in poverty	Recruitment completed	Intervention	2020-04-22	<NULL>	<NULL>	3766	Education intervention to promote the resilience of adolescents in poverty situation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8kjtps	<NULL>	Public school adolescents; between 11 and 17 years old; minimum frequency of 75% in classes; being in poverty.	Some cognitive problem	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-52twgg	Effect of caffeine supplementation on physical performance and oxidative stress during high-intensity exercises	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3767	Effect of caffeine supplementation at physical performance and balance redox during a high-intensity interval training (HIIT) protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-20	Universidade Federal do Paraná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-52twgg	<NULL>	Recreationally active adults; practicing strength training at least 150 minutes a week; male	Habitual caffeine users; individuals not used to strength training; be participating in another study during the analyzes; present an injury or physical impairment that prevented the tests from being performed; cardiovascular diseases; smoker; use of other supplements during testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-2mht7h	Use of two chemical aids in the treatment of Chronic Periodontitis	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3768	Comparative evaluation of two chemical gel adjuvants in the treatment of Chronic periodontitis: chlorhexidine 1% x melaleuca 2.5%, a double blind randomized controlled clinical study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Centro de Estudos Superiores de Maceió	Centro de Estudos Superiores de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-2mht7h	<NULL>	The sample consisted of systemically healthy patients; age range 18 to 60 years old; diagnosed with chronic periodontal disease.	The exclusion criteria consisted of patients presenting   any negatively tissue healing pathology (eg diabetes mellitus); pregnant and breastfeeding women; participants who were allergic to the study adjuvants; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-4hb9qs	"Efficacy of Auriculotherapy in treatment of chronic pain caused by
Chikungunya"	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3769	"Efficacy of Auriculotherapy in Analgesia of chronic pain caused by
Chikungunya: randomized controlled clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4hb9qs	<NULL>	have a clinical and / or laboratory diagnosis of chikungunya; having been in pain for at least three months; be aged between 18 and 80 years; having preserved cognitive functions	"having a previous cancer diagnosis;
being on immunosuppressive drugs; have been hospitalized up to 30 days before the start of auriculotherapy sessions"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9ybbch	Effects of Manual Techniques versus an Exercise Program on Low Back Pain in Karate Fighters: experimental study	Data analysis completed	Intervention	2019-10-10	<NULL>	<NULL>	3770	Effects of Manual Therapy versus an Exercises Program on Low Back Pain in karate fighters: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	centro universitário unieuro	centro universitário unieuro	https://ensaiosclinicos.gov.br/rg/RBR-9ybbch	<NULL>	Individuals that presented with acute lower back pain; Karate practitioner for at least six months; That they agreed not to undergo any physiotherapeutic treatment or other rehabilitation procedure during the study period; Individuals who did not change their physical exercise habits during the study period.	"They had degenerative pathologies; Cardiovascular diseases,
Metabolic diseases; History of musculoskeletal injury in a period of six months prior to the survey; Cognitive deficit or non-collaborative patient; Illiterate or had difficulty understanding; Missed two consecutive appointments."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8qq5h9	Natural Killer imune cells expansion for Acute Myeloid Leukemia treatment.	Not yet recruiting	Intervention	2020-04-24	<NULL>	<NULL>	3771	Phase I/II clinical trial with expanded ex vivo Natural Killer (NK) cells to treat Acute Myeloid Leukemia (AML)	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-01-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-8qq5h9	<NULL>	Patients with relapsed acute myelogenous leukemia, including CNS diseases or previous hematopoietic stem cell transplantation, who have failed remission for at least one cycle of standard or experimental re-induction chemotherapy or primary refractory AML (primary AML failed to achieve remission after at least two cycles of induction therapy); Patient with high risk AML or MDS without donor for allogeneic transplantation available at the time of therapy; Patients with performance status ? 2 on Zubrod scale (ECOG) or Lansky 60; Organic function with respiratory capacity 50%, pulmonary symptoms controlled by medication and pulse oximetry greater than or equal to 92%; Creatinine ?2 mg / dL for adults, ?2 mg / dL or ?2 the upper limit of normal for age for children, or with creatinine clearance ?60 mL / min / 1.73 m2; Total bilirubin ? 2 mg / dL or TGP (ALT) &lt;2.5 x ULN for age (unless Gilbert&apos;s disease or abnormal liver function due to primary disease); Classification New York Heart Association&gt; III; Negative pregnancy test for women of childbearing age (non-fertile age defined as pre-menarche, post-menopausal over one year, or surgically sterilized); Acceptance of the use of contraceptive methods by sexually active men and women of childbearing age; Patient should have recovered from the toxicity related to previous treatment of cytotoxic agents received within 4 weeks before starting treatment in this protocol (with the exception of cytopenias resulting from persistent disease and alopecia)	Patients with high-risk AML and MDS with active, HIV-positive hepatitis B or C; With liver cirrhosis; Uncontrolled infections; Female patients with positive pregnancy test; Congestive heart failure &lt;6 months before screening; Unstable breast angina &lt;6 months before selection; Myocardial infarction &lt;6 months before selection; Non-signing free and informed consent term	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-5zsjrd	Analysis of body mass index (BMI) and diet of adults with Down syndrome and their caregivers in the process of nutritional guidance	Recruiting	Intervention	2020-04-24	<NULL>	<NULL>	3772	Analysis of the nutritional status and eating habits of adults with DOWN SYNDROME and their main caregivers in the process of health education and nutritional intervention	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-03	Faculdade de medicina da USP	Faculdade de medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5zsjrd	<NULL>	Adult volunteers with down syndrome and their primary caregiver; both genders; aged between 19 and under 35.	Volunteers with ostomies, Hirschsprung&apos;s disease, severe intellectual disability, decompensated heart disease, food allergies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-7hbmjp	Clinical evaluation of resin restorations of posterior teeth performed at the são luis dental specialty Center - randomized clinical trial	Recruitment completed	Intervention	2020-03-10	<NULL>	<NULL>	3773	Retrospective evaluation and randomized clinical trial of posterior direct restorations performed in dental specialty centers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-04	Suellen Nogueira Linares Lima	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7hbmjp	<NULL>	Need restorative treatment with composite resin on 2 posterior teeth; aged between 18 and 70 years; agree to participate in the study; having a medical history that does not compromise the evolution of the results; having the habit of oral hygiene that involves brushing at least twice a day; having a normal periodontal condition in relation to the probing parameters.	Patients with a chronic disease with oral manifestations; present any oral pathology considered serious; high caries activity; severe periodontal problem that may compromise the direct restoration of the posterior tooth; allergies to any material that will be used at work; signs or symptoms of bruxism and dental clenching; teeth that will be used as a pillar for removable dentures or fixed partial dentures; teeth with porcelain restoration directly opposite the tooth that will receive the research restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9j767y	Comparison between Laser Acupuncture Versus Medications in Pain Reduction after Wisdown Tooth Removal	Recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3774	Evaluation of the Effect of Laser Acupuncture on Pain and Edema after Extraction of Impacted Lower Third Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Departamento de Odontologia da Faculdade de Ciências da Saúde da Universidade de Brasília	Instituto de Gestão Estratégica do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-9j767y	<NULL>	Age equal to or greater than 18 years; general good health (ASA I or II); indication of bilateral extraction of included third molars (intraosseous inclusion) under similar conditions on both sides and requiring ostectomy for their removal	Use of any analgesic medication in the last 15 days; pregnant women; lactating; when there is presence of pericoronaritis related to the lower third molar; individuals with a history of allergies or adverse effects to the drugs used in the study; individuals who have already undergone previous acupuncture treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9snttn	Effect of supplementation with the amino acid leucine and the compound Beta-hydroxy-beta-methyl-butyrate on the nutritional status, muscle mass, functionality and blood tests of patients on the waiting list for liver transplantation	Not yet recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3775	Effect of Leucine and Beta-hydroxy-beta-methyl-butyrate supplementation on nutritional status, lean mass, functionality, biochemical and molecular markers of patients on the waiting list for liver transplantation	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Santa Casa de Misericoridia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-9snttn	<NULL>	Patients on the waiting list for liver transplantation; both genders; age over 18 years	Pregnant and lactating women; vegetarians; allergic to milk and soy proteins; lactose intolerant; patients taking nutritional supplements of free amino acids; patients using progestational agents, steroids and growth hormone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-3ftcvj	Physical condition in the individual with Cirrhosis	Not yet recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3776	Physical Rehabilitation in the cirrhotic individual	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-30	Danusa Rossi	Danusa Rossi	https://ensaiosclinicos.gov.br/rg/RBR-3ftcvj	<NULL>	"adults aged 18 to 70 years, both sexes, cirrhotic, with the disease stabilized, in
medical follow-up at the Liver Transplantation Clinic of Santa Casa de Porto Alegre, who accept to participate in the research."	decompensation of liver disease characterized by Child Pugh Score Class C, hospitalization in the last three months, with degenerative neuromuscular diseases and / or orthopedic changes that compromise the results of physical tests, which present absolute contraindications for testing and patients with comorbidities diseases not associated with liver disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-952kfh	Evaluation of two  plastic bags to prevent admission hypothermia in preterm babies less than 34 weeks of gestational age	Data analysis completed	Intervention	2018-07-24	<NULL>	<NULL>	3777	Evaluation of two  polyethylene plastic bags to prevent admission hypothermia in preterm babies less than 34 weeks of gestational age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-18	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-952kfh	<NULL>	Preterm inborn infants; with less than 34 weeks of gestational age; both gender.	No measurement of temperature at hospital admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-92cts3	Prevention of radiation induced dermatitis in cancer patients	Recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3778	Prevention of radiodermatitis in cancer patients: a randomized clinical trial	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade de Brasília	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-92cts3	<NULL>	Being an adult, over the age of 18 years old; Owning diagnosis of breast cancer or head and neck cancer; Being first referred to the radiotherapy protocol; Have integrates skin to start radiotherapy.	Have presented anticipated reaction of hypersensitivity to chamomile or any plant of the family Asteraceae or Compositae.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-35szqq	Use of biological glue in the surgery of retained third molars	Data analysis completed	Intervention	2020-04-29	<NULL>	<NULL>	3779	Comparison of mucosal healing with the use of suture and biological glue in retained third molar surgery: a pilot project	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-26	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-35szqq	<NULL>	Healthy volunteers; both genders; age between 18 and 40 years; presence of two retained lower third molars.	Volunteers with systemic diseases that alter bone metabolism; diabetes mellitus; uncontrolled heart disease; blood clotting problems; healing problems; undergoing chemotherapy or radiation therapy; immunodepressed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-2mmbpn	Hatha-Yoga as a mental health care intervention: randomized clinical trial with women deprived of their liberty	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3780	Care practices aimed at the female population under deprivation of liberty in a prison unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-04	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2mmbpn	<NULL>	Women in a closed prison system; Established legal situation (sentenced prisoners);	Women in semi-open or open prison; Established legal situation (sentenced prisoners) who were working in prison or who were pregnant at the time the intervention started; Women fulfilling socio-educational measures; Women with open legal status (provisional prisoners).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-6w5tbk	Effects of tests for covid-19 on the preservation of the healthcare workforce during pandemia in Brazil	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3781	Effectiveness of a protocol based on rt-pcr and serology tests for sars-cov-2 for the preservation of the healthcare workforce during covid-19 pandemia in Brazil: a parallel group, randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-30	Hospital Universitário de Brasília	Cleandro Pires de Albuquerque	https://ensaiosclinicos.gov.br/rg/RBR-6w5tbk	<NULL>	Healthcare professional; directly involved in the care of patients; temporarily removed from work, because of suspected COVID-19 due to respiratory symptoms or fever	Age greater than 60 years; diabetes; cardiopathy; chronic lung disease; chronic kidney disease; onco-hematological diseases in the last five years; immunossupression; compromised general health; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-94857q	Identification of taste changes and nutritional implications in cancer patients	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3782	Identification of taste changes and nutritional implications in cancer patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-94857q	<NULL>	Age equal to or greater than 18 years; being on cancer treatment; ability to eat orally; express interest in participating in the research by signing the Free and Informed Consent Form.	Presence of head and neck cancer; be a smoker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-4j62sf	Effect of Pilates and Exercises for trunk muscles in elderly people with low back pain	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3783	Effect of the Pilates method and Segmental Stabilization in the elderly with non-specific chronic Low back pain: randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4j62sf	<NULL>	Both genders; age over 60; nonspecific low back pain for at least 3 months; pain intensity equal to or greater than 3 cm	Specific low back pain; neurological involvement (radiculopathy or myelopathy); previous spine surgery; impediment to performing exercises; recent surgery; being under treatment for low back pain; body mass index (BMI) greater than or equal to 27; not being able cognitive to perform the exercises or be submitted to the proposed evaluations; missing the attendance three times in a row	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-5gjrzz	Effects of single and double task in elderly people with Toxoplasmosis	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3784	Analysis of the effects of single and dual task in elderly people infected with toxoplasma gondii:  A randomized controlled trial double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Faculdade de ciências da saúde do trairi-UFRN	Faculdade de ciências da saúde do trairi-UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5gjrzz	<NULL>	Volunteer individuals aged at least 60; of both sexes; and have good cognitive status to understand simple commands	Individuals with severe orthopedic; neurological; rheumatological diseases and who have undergone any physical therapy treatment in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-92pm68	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3785	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital Central do Exército	Hospital Central do Exército	https://ensaiosclinicos.gov.br/rg/RBR-92pm68	<NULL>	Patients over 18 years old; with pre-anesthetic physical status classification according to the American Society of Anesthesiology ( ASA) 1  or 2, that is,   without functional limitation  or slight limitation.	The following factors are considered exclusion criteria: refuse of the patient or guardian; cervical spine surgery; head and neck tumors or anatomical deviations of the airway; mandibular joint disease; cervical mobility restriction; coagulation disorders; morbid obesity and risk of bronchoaspiration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8zpnxz	Stimulation direct in the head effects in muscle fatigue in amateur runners	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3786	Transcranial direct current stimulation effects in muscle fatigue in amateur runners	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-25	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8zpnxz	<NULL>	People with 25 to 50 years old; 5 to 21 km runners training at least 2x / week and one other physical activity for at least once a week for at least six months; agree to participate in the study by the informed consent form and agree not to modify their training routine during the study period (eg modify running or weight training), but will be advised not to perform physical activity during the 24 hours preceding the study.	No medical certificate to participate in the study; Women who are pregnant or who become pregnant during the study period; Volunteers with lower limb Skeletal Muscle System injury or injured during the study period; Make use of central  drugs (antihistamine, anti-depressant, anti-epileptic);To have any metal implant in the head; No response to the resting motor evoked potential of the quadriceps muscle with the stimulation of Transcranial Magnetic Stimulation; Contraindications to the use of transcranial Direct Current Stimulation (history of convulsion, tumors or skin infection at the stimulation site, and metallic materials implanted in the brain).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-97phmj	Conservative caries treatment	Recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3787	Minimally invasive treatment of approximal carious lesions: a randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-97phmj	<NULL>	Older adults and teenagers over thirteen years old with permanent teeth with a proximal radiographic image located on the entire enamel or even external half of dentin with cavitation	Teeth with fixed orthodontic appliance that make clinical or radiographic examination impossible; teeth that present occlusal restoration with communication to the lesion of the proximal surface; teeth with lesions that extend to the root surface	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-6k7pkv	Effect of martial arts on cognition, physical abilities and school performance in students.	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3788	Effect of a Martial Arts-Based Program on Cognitive Functions, Academic Performance, and Physical Ability in elementary school students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	GENSC - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-6k7pkv	<NULL>	Healthy volunteers; both genders; age between 8 and 12 years; enrolled in the educational institution of the study.	diagnosis of any physical limitation that prevents the intervention program and the physical test from being performed; have any psychological disorder or disorder that affects cognitive performance; diagnosis of eye diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-57yqwb	Effects of Intermittent Fasting and Low Calorie Diet on health parameters and body weight	Data analysis completed	Intervention	2020-04-29	<NULL>	<NULL>	3789	Metabolics effects and body composition of individuals submitted to Intermittent Fasting or Continuous Caloric Restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-57yqwb	<NULL>	"Be training regularly under professional supervision;
Be aged between 18 and 40 years;
Have a BMI equal to or greater than 24.99 kg / m2;
Agree to perform biochemical tests on your own"	subjects with kidney diseases; hormonal diseases and limiting joint diseases; heart disease and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-928hcw	Effect of acute consumption of green tea (Camellia sinensis) on energy metabolism, satiety sensation and food intake	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	3790	"Effect of allegedly thermogenic tea intake on metabolism energy, feeling full and food intake of individuals with excess of
Weight"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-29	Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-928hcw	<NULL>	Will be included in this study individuals with stable weight; non smokers; who do not use dietary supplements or medications except oral contraceptive; that may interfere with the study results.	Diabetics; hypertensives; carriers of diseases that interfere with energy metabolism; allergic or sensitive to any of the standard breakfast ingredients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-6wkrrd	Description of the clinical characteristics of patients with inflammatory bowel diseases in public hospitals at northeastern Brazil	Recruiting	Observational	2020-04-29	<NULL>	<NULL>	3791	Characterization of the clinical-epidemiological profile on Inflammatory Bowel Disease in a prospective cohort at referral outpatient clinic unit in some States in the Northeast of Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-19	Instituto Autoimune	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6wkrrd	<NULL>	Individuals diagnosed with Crohn&apos;s disease, ulcerative colitis or colitis undetermined, proven by clinical, radiological, endoscopic and ; or histopathological tests, which maintained regular follow-up at the outpatient inflammatory bowel disease of the Gastroenterology service in the hospitals involved in the project.	Absence of criteria for definitive diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-8m47vs	Effect of in-office dental bleaching with  violet light	Recruitment completed	Intervention	2020-04-30	<NULL>	<NULL>	3792	Effectiveness, longevity and sensitivity of in-office dental bleaching with the use of violet light: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade de Pernambuco	Faculdade de Odontologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8m47vs	<NULL>	"Both gender;
Aged between 18 and 35 years old;
Who have good overall and oral health;
Caries-free upper anterior teeth;
Absence of cervical lesions;
Absence of restorations on the buccal surface;
Periodontal health must be preserved;
Center incisors should be C2 or darker according to a value oriented color scale (Vita Lumin, Vita Zahnfabrik, Bad Säckingen, Germany)"	"Aprenda a pronunciar
Participants with previous pre-existing restorations;
Pregnant / lactating women;
Teeth with severe discoloration
Those who have drugs with habits;
Use of anti-inflammatory drugs;
Bruxism or any other condition that may cause dentin sensitivity;
Smokers;
That have undergone some kind of whitening treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-8k4f68	Association of the level of mobility of adult patients in the ICU with the successful removal of mechanical ventilation: protocol for an observational study	Other	Observational	2020-04-30	<NULL>	<NULL>	3793	Association of the mobility level of critically ill patients with the successful withdrawal of mechanical ventilation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universiidade Federal de São paulo	Universiidade Federal de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k4f68	<NULL>	age 18 to 90 years; admitted to the intensive care unit; under invasive mechanical ventilation for 24 hours or more; with mobility preserved prior to hospitalization.	Neurological disease; neuromuscular disease; degenerative muscle disease; brain or spinal cord trauma; inability to communicate in Portuguese; severe cognitive impairment prior to admission to the ICU; unstable fractures; burns; injury requiring rest prescription; palliative care; amputation of lower members.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4psxby	Comparison of Techniques for Treatment of Gingival Recessions	Recruiting	Intervention	2020-04-30	<NULL>	<NULL>	3794	Comparison of Root Coverage Techniques	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4psxby	<NULL>	Volunteers with unitary shallow gingival recessions (less than 4mm), unilateral, type 1 (RT1), in upper or lower canines or premolars; with clinically healthy periodontium and no radiographic bone loss; both sexes; aged between 18 to 55 years.	Volunteers using orthodontic appliances; smokers; pregnant or infants; with previous history of mucogingival or periodontal surgery, fixed or removable prosthodontics, dental cavities, pulp pathology or severe malocclusion involving teeth with gingival recession to be chosen for the study; medication users and/or patients with systemic diseases that may interfere with healing or periodontal health.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-2yzkhy	Evaluation if Physical Exercise in Virtual Mode Will Reduce Blood Pressure in Hypertensive People.	Recruiting	Intervention	2020-04-30	<NULL>	<NULL>	3795	Effect of a Physical Training Program Through Virtual Rehabilitation in Individuals with Hypertension.	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2yzkhy	<NULL>	"both sexes; age between 40 to 80 years;
able to perform physical activity; sedentary for at least three months"	Grade III and grade IV heart failure individuals; Acute myocardial infarction; Individuals with unstable angina; Individuals with acute pericarditis; Individuals with pulmonary hypertension and uncontrolled diabetes mellitus; Individuals with attendance below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5hz86t	Effect ingest of Hibiscus sabdariffa tea on energy metabolism, subjective satiety responses and food intake of healthy individuals.	Recruitment completed	Intervention	2020-04-30	<NULL>	<NULL>	3796	Effect of ingestion of supposedly thermogenic teas on metabolism energy, feeling full and eating in individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hz86t	<NULL>	BMI between 18.5 to 26kg / m2; stable weight in the last 3 months; no use of dietary supplements or medications except oral contraceptive; non-smokers.	Diabetics; hypertensives; carriers of diseases that interfere with energy metabolism; allergic or with some sensitivity to standardized breakfast ingredients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5x82zr	Vitamin D deficiency in children and adolescents with Type I Diabetes Mellitus: influence of vitamin D supplementation and variations in the Fok-I gen on glycemic control	Not yet recruiting	Intervention	2020-04-30	<NULL>	<NULL>	3797	Vitamin D deficiency in children and adolescents with Type I Diabetes Mellitus: influence of vitamin D supplementation and Fok-I polymorphism on glycemic control	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Rio de Janeiro	Instituto de Puericultura e Pediatria Martagão Gesteira	https://ensaiosclinicos.gov.br/rg/RBR-5x82zr	<NULL>	Age between 7 and 16 years;diagnosis of type 1 diabetes for at least 1 year	Other autoimmune diseases; sickle cell anemia; kidney or liver disease; genetic syndromes; intestinal malabsorption or hemoglobinopathies; use drugs that affect the metabolism of vitamin D, corticosteroids and insulin pump; and have recently supplemented with vitamin D.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-2gc2qj	The effect of the Pilates Method for type 2 Diabetics	Recruitment completed	Intervention	2020-05-04	<NULL>	<NULL>	3798	Impact of an exercise protocol based on the Pilates Method on oxidative stress and functionality of Diabetics type 2	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Fundação Universidade Federal do Piauí	Fundação Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2gc2qj	<NULL>	Be enrolled in Hiperdia, with a proven clinical diagnosis of type 2 diabetes mellitus; reside in the municipality of Parnaíba; be between 35 and 80 years old; have sufficient cognitive and physical capacity to perform the evaluative procedures and participate in the exercise protocol; agree to participate in the research by signing the informed consent form	Patients who do not participate in the complete exercise protocol and who request the withdrawal of consent during the research will be excluded from the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5746z9	Impact of photobiomodulation in the salivary flow of patients treated with radiotherapy and chemotherapy for head and neck cancer: double blind and randomized  pilot study.	Data analysis completed	Intervention	2020-05-04	<NULL>	<NULL>	3799	Impact of photobiomodulation in the salivary flow of patients treated with radiotherapy and chemotherapy for head and neck cancer: double blind and randomized  pilot study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-23	Próprio pesquisador	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5746z9	<NULL>	Patients with cancer of the head and neck (oral cavity, pharynx, larynx and occult primary) with indication of treatment with radiotherapy; Patients that the irradiation field must include all major salivary glands.	"Patients younger than 18 years or incapacitated to answer questions; Initial tumors (T1 and T2) and limited to the larynx, other sites such as metastases and skin tumors; Indication of RT with palliative intent; Patients with Diabetes Melitus, autoimmune, infectious and collagen diseases.
Patients who use drugs that may interfere with the salivary flow; Patients with trismus or limitation of mouth opening due to surgical sequelae."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-7jvk8k	Development of teaching models for echocardiographic imaging planes in dogs and cats	Recruitment completed	Intervention	2020-05-04	<NULL>	<NULL>	3800	Development of Teaching Models for Imaging Planes Ecocardiographic in dogs and cats	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-03	Universidade Federal do Paraná	Departamento de Medicina Veterinária da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7jvk8k	<NULL>	Fourth year veterinary students who are attending the small animal medical clinic	Students who do not complete an hour of study in the models	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4t8q6z	Influence of genetic variants on health-related assessments and on the effect of Physical Training on the elderly	Data analysis completed	Intervention	2018-02-20	<NULL>	<NULL>	3801	Influence of genetic polymorphisms in physical fitness, functional capacity, incidence of falls and response to Physical Training in elderly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-11	Escola de Educação Física e Esporte de Ribeirão Preto	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4t8q6z	<NULL>	Men and women with different levels of physical activity and aged between 50 and 80 years.	To present some medical, mental or musculoskeletal conditions that could prevent the performance of the motor tests and the physical training program; presenting a body mass index greater than 35 kg/m2, resting systolic blood pressure greater than 160 mmHg and resting diastolic blood pressure greater than 100 mmHg; have a frequency of less than 75% in the activities proposed by the intervention (in this case, it would not carry out the reassessment; only initial data used in the cross-sectional analysis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-58vsqp	Action of the Anti-Reflux Mattress Adapter in patients with Reflux Disease	Recruitment completed	Intervention	2017-11-14	<NULL>	<NULL>	3802	Influence of anti-reflux mattress adapter on the amount of gastroesophageal reflux in adult patients with symptoms of gastroesophageal reflux disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Hemocentro de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58vsqp	<NULL>	Volunteers with gastroesophageal reflux disease; both genders; age between 20 and 60 years; with symptoms of regurgitation and heartburn; with result of digestive endoscopy without other changes in the esophagus.	Volunteers with other changes in the esophagus; diagnosis of neurological, immunological, neoplastic and drug users for coronary diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5s2mqg	The effect of an inhibitor of pulmonary inflammation in patients with Covid-19	Recruiting	Intervention	2020-05-05	<NULL>	<NULL>	3803	Evaluation of the efficacy and safety of pharmacological inhibition of bradykinin for the treatment of Covid-19	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2020-04-27	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5s2mqg	<NULL>	Patients aged 18 years at the time of signing Consent Form, 12 days since onset of the symptoms until the start of treatment, SARS-CoV-2 diagnosis by RT-PCR method, pneumonia confirmed by computed tomography of the chest, hospitalized patients with a SpO2 &lt; 94% in ambient air or Pa02/FiO2 &lt; 300 mmHg, the patient or responsible family member (incapacitated patients) must have signed the consent form, the patient must agree not to enrol in any other experimental study prior to completing the 28-day follow-up.	Women in pregnancy or breastfeeding (pregnancy-beta-HCG-test will be performed in women of childbearing age), known severe renal impairment (estimated glomerular filtration rate &lt; 30 ml/min/1.73 m2), or patients receiving continuous renal replacement therapy (hemodialysis or peritoneal dialysis); or previous renal transplant; known severe liver disease (AST or ALT 5X above the reference value); patients diagnosed with HIV infection or patient with any other immunodeficiencies; patients with the previous diagnosis of cancer; patients with the previous diagnosis of hereditary angioedema; patients with previous ischemic myocardial disease; patients with previous thromboembolic disease; if the assisting physician considers that the participation of the patient in the study is not appropriate, either because it is not of clinical interest or because of any condition that does not allow the protocol to be followed safely; the patient will be transferred to any other hospital before the 28 days of follow-up or before a disclosure (discharge from hospital); receipt of any experimental treatment for COVID-19 virus infection within 30 days prior to molecular screening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-3k4wxb	Evaluation of the use of Hydroxychlorochine in Chinese flu	Not yet recruiting	Intervention	2020-05-05	<NULL>	<NULL>	3804	Evaluation of the use of Hydroxychlorochine in patients with discrete form of Covid-19: randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital Santo Antônio	Hospital Santo Antônio	https://ensaiosclinicos.gov.br/rg/RBR-3k4wxb	<NULL>	Positive RT-PCR; age&gt; 18 years;  discrete classification (without signs of dyspnea, and oximetry greater than 93%)	Need for ICU on day 0; allergy to hydroxychloroquine or azithromycin; retinopathy; G6PD deficiency; QT extension; lactation; pregnancy; hepatic insufficiency; acute renal failure; patients who did not sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4m6yr2	Evaluation of sensitivity after home bleaching by applying bleaching gel with and without desensitizing agent	Data analysis completed	Intervention	2017-03-28	<NULL>	<NULL>	3805	Evaluation of dental bleaching sensitivity at home applying bleaching gel with and without desensitizing agent - randomized, triple blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4m6yr2	<NULL>	Patients with good general health will be included in this study; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who have undergone previous bleaching procedures will be excluded; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-83cd7j	Evaluation of dental sensitivity  after restoration in posterior teeth applying a dentin wet adhesive vs. dry	Data analysis completed	Intervention	2017-06-27	<NULL>	<NULL>	3806	Evaluation of post-operative sensitivity in posterior restorations with an adhesive system applied on moist vs. Dry dentin: a double-blind, randomized, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-83cd7j	<NULL>	Patients with good general health will be included in this study; Age: between 18-50 years of age; Good oral hygiene; Present at least 20 teeth under occlusion; At least two carious lesions and / or indication of replacement restoration (fracture, secondary caries, temporary restoration), one in each hemiarco with a minimum depth of 3 mm.	Patients with extremely poor oral hygiene will be excluded; Severe or chronic periodontitis; Severe bruxism; Parafunctional habits; Continuous use of medication that may alter the perception of pain (analgesic, anti-inflammatory); Patient undergoing bleaching treatment; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-3z98rp	Hearing aids effects on cerebral function among elderly	Recruitment completed	Intervention	2020-05-05	<NULL>	<NULL>	3807	Hearing aids effects on elderly cognition, attention and memory	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Irmandade da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z98rp	<NULL>	&gt; 60 years old, sensorineural hearing loss not greater than 60 dB between 250 and 4000 Hz), never used hearing aid before.	Research drop-out; score &lt; 26 on Montreal Cognitive Assessment (MoCA) indicating neurocognitive abnormalities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-97pgg7	Self-esteem, body image and quality of life of elderly women who practice weight training	Recruitment completed	Intervention	2020-05-05	<NULL>	<NULL>	3808	Self-esteem, body image and composition and quality of life of elderly women participating in a resistance exercise program	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-08-20	Samaris Aprígio de Souza	Faculdade de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-97pgg7	<NULL>	Elderly women; without practicing systematic physical activities for at least 3 months; considered fit for the practice of resistance exercise under medical certificate.	Uncompensated volunteers in hypertension and diabetes mellitus; volunteers on dialysis therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4tkys8	Evaluation of dental office bleaching sensitivity with bleaching gel with and without desensitizing agent	Data analysis completed	Intervention	2017-01-18	<NULL>	<NULL>	3809	Evaluation of tooth sensitivity after in office dental bleaching applying whitening gel with and without desensitizing agent - randomized clinical trial, triple blind	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4tkys8	<NULL>	Patients with good general health will be included; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded: undergoing previous bleaching procedures; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-9wbczd	Evaluation of bloodletting to control hypertension in dental patients	Recruitment completed	Intervention	2020-05-06	<NULL>	<NULL>	3810	Evaluation of Bloodletting as a Method of Immediate Control of Blood Pressure in Patients submitted to Procedures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9wbczd	<NULL>	Age equal to or over 18 years, ASA I or ASA II, who needed to undergo dental procedures that required local anesthesia and had BP greater than 140 / 90 mmHg using or not anti hypertensives.	Diabetics, hemophiliacs, alcoholics, pregnant women, individuals with needle phobia, odontophobia, mental disability and using anxiolytics or antiplatelet agents	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-2n24qg	Measurement of knee injury risk in amateur and professional athletes from different sports before and after training	Recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3811	Quantification of knee ligament injury risk  in youth athletes and in professional athletes from different sports before and after functional interventions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-2n24qg	<NULL>	The inclusion criteria are: to be a player in any sport, such as: volleyball, soccer, handball, basketball, rugby, futsal, tennis and athletics; conduct training at least three times a week; conduct training for at least one hour a day; have been practicing a sport for at least six months; be able to carry out the activities proposed by a specific evaluation instrument; be aged 11-30 years.	"The criteria for non-inclusion: conduct training less than three times a week; conduct training lasting less than one hour a day; be a practitioner of a sport for less than six months; be under 11 years old and over 30 years old.
The exclusion criteria: being unable to perform the activities proposed by a specific evaluation instrument; stop training; termination of the participating team / transfer to a non-participating team; for health reasons that make it impossible to continue the study (for example: injury, illness, pregnancy, death)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-536yfm	Prematurity	Not yet recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3812	Prematurity: risk factors and childhood development	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-536yfm	<NULL>	The studied patients will be preterm newborns; and with gestational age equal to or greater than 24; and minimum corrected age of 32 weeks; of both sexes; admitted to the Intensive Care Unit; and / or in the joint accommodation; with a current weight equal to or greater than 1500g; clinically stable; and hemodynamically; and breathing in ambient air; at the time of assessment, these being the study inclusion criteria.	Newborns with congenital malformations will be excluded; or genetic syndrome that compromises respiratory biomechanics; and congenital heart diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4sp5w6	The effect of Botulinum Toxin type A in patients with axillary Suppurative Hidradenitis	Not yet recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3813	Botulinum Toxin A for the Treatment of Hidradenitis Suppurative Axillaris: Randomized Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal de São Paulo- UNIFESP	Universidade Federal de São Paulo- UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4sp5w6	<NULL>	"18 years old or more;
Patients with bilateral axillary hidradenitis in the stage II-III according to Hurleys classification;
At least one year with the disease;"	"Pregnant or lactating women;
Hypersensitivity to botulinum toxin
Neuromuscular diseases, such as myasthenia gravis or motor neuron disease
Use of aminoglycoside antibiotics or other drugs that interfere with neuromuscular transmission.
Patients receiving systemic treatment with immunobiological or retinoid or immunosuppressive drugs in the last 3 months.
Patients receiving oral antibiotic, or infiltration of corticosteroid or surgical intervention for hidradenitis in the treated area within 4 weeks of initiation of the study.
Patients who received botulinum toxin type A treatment in the treated area in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-69d7cz	Evaluation of dental sensitivity after restoration in posterior teeth by applying a conventional adhesive with damp dentin. dry	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	3814	Evaluation of postoperative sensitivity in further restrictions applying a conventional adhesive in dentina ummida vs. dry: randomized, double-blind clinical test	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-69d7cz	<NULL>	Patients with good general health; Age: between 18-50 years of age; Good oral hygiene; Present at least 20 teeth under occlusion; At least two carious lesions and / or indication of replacement restoration (fracture, secondary caries, temporary restoration), one in each hemiarco with a minimum depth of 3 mm.	Hygiene will be excluded; Severe or chronic periodontitis; Severe bruxism; Parafunctional habits; Continuous use of medication that may alter the perception of pain (analgesic, anti-inflammatory); Patient undergoing bleaching treatment; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-9jd7b7	Effects of the intensity of Interval Training on aerobic fitness, body composition and resting metabolic rate of women with Overweight or Obesity: a randomized controlled trial	Data analysis completed	Intervention	2020-05-06	<NULL>	<NULL>	3815	Effectiveness of two different Training approaches in body composition (cc) and cardiorespiratory resistance (rc) in an interdisciplinary program for adults with Overweight or Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Centro Universitário de Maringá	Centro Universitário de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9jd7b7	<NULL>	Volunteer women; aged between 18 to 45 years; sedentary; body mass index equal or greater than 25 kg/m2; stable body weight in last three month.	Comorbidities or pathologies associated, except those of metabolic syndromes; use of medications and/or supplements to weight-loss; performing a restrictive diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8bpt29	The effect of Resistance Training on elderly women with High Blood Pressure	Recruitment completed	Intervention	2020-05-06	<NULL>	<NULL>	3816	Influence of Resistance Training on blood pressure and heart rate control in Hypertensive elderly women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8bpt29	<NULL>	Age between 60 and 75 years; physically inactive for at least 6 months; medical diagnosis of hypertension; using antihypertensive medication; no previous history of severe cardiovascular disease or cardiovascular events; no osteomioarticular lesions that limit the ability to exercise; without estrogen replacement therapy	Smoker; diagnosis of diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4bnbn3	Study of two types of distribution of protein on muscle mass and strength gains in young men submit to strength training	Recruitment completed	Intervention	2020-05-06	<NULL>	<NULL>	3817	Study of two patterns of protein distribution on muscular hypertrophy and strength in young men submit to strength training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4bnbn3	<NULL>	at least 1 year of previous experience in resistance training; absence of chronic condition precluding participation; absence of any metabolic diseases.	prior use of anabolic steroids; and current use of ergogenic supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4pj29v	The effect of Demonstration associated with Verbal Instructions on body alignment during a Classical Ballet jump	Recruiting	Intervention	2018-07-04	<NULL>	<NULL>	3818	The effect of Augmented Feedback on lower limb and trunk kinematics during a Classical Ballet jump: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-28	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4pj29v	<NULL>	Participants should be women; age between 15 and 35 years; Body Mass Index below 24.9 kg/m2; practicing classical ballet for at least one year; regularly practicing classical ballet for at least 2 hours/week; not presenting with pain in the lower limbs at the time of assessment; and presenting with altered dynamic lower limb alignment during the step descent test. This criterion will be defined by performing the lateral step-down test described by Rabin and Kozol (2010)	Participants should not have undergone any surgery in the last 6 months; be presenting with a history of fracture or surgery in the lower limbs; be presenting with any of the following conditions: joint effusion, ligament injuries, diagnosis of recent lower limb injury, and history of neurological, vestibular or visual deficits; and have suffered, in the last 6 months, injury that had prevented the participant from training for more than two weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-563hhy	Effect of auricular acupuncture in breastfeeding	Recruiting	Intervention	2020-05-07	<NULL>	<NULL>	3819	Effectiveness of auricular acupuncture in breastfeeding: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-27	Escola de Enfermagem de Ribeirão Preto	Escola de Enfermagem de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-563hhy	<NULL>	Lactating mothers with low milk production will be enrolled in study, that is whose breastmilk volumes failed to meet their infants&apos; requirements; 18 and older; between 5 and 30 days of postpartum.	To make use of galactogogues drugs during the research period; Being a smoker; history of breast surgery (breast reduction surgery or breast implant); never had made the auricular acupuncture before; pregnancy and delivery with any complications; baby who have an weight smaller than 2.500g and larger than 4.000g; twin pregnancy; preterm birth; be allergic to any materials used in auricular acupuncture; make use of other energy therapies (herbal treatments, Reiki, Flower therapy, homeopathy, etc); the patient has no time available to do the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-77g3mf	The Effect of Exercise and Elastic taping on Knee Tendonitis	Suspended	Intervention	2017-08-16	<NULL>	<NULL>	3820	Efficacy of adding the Dynamic Taping method to guideline-endorsed based physiotherapy exercises in athletes with Chronic Patellar Tendinopathy: a randomised controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Departamento de Fisioterapia da Universidade Federal do Ceará	Tendon Research Group	https://ensaiosclinicos.gov.br/rg/RBR-77g3mf	<NULL>	Both sexes, with ages varying from 18 to 45 years, with diagnosis of Patellar Tendinopathy; Increased pain on palpation without tendon; Increase of pain to the increase of load; Reproducing the symptoms when jumping, crouching or climbing stairs), who sign the Informed Consent Term (TCLE).	History of patellofemoral pain; Knee arthrosis; Reconstruction of anterior cruciate ligament; Muscular or skeletal injuries that do not allow the exercises to be performed; Severe cardiac conditions or other pathological conditions that make physical therapy impossible; Who underwent patellar tendon surgery, and if the subjects have one of these conditions during the treatment period, they will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-9pjkgw	Effect of a complementary practice that uses comedy films during the dialysis procedure in the levels of stress, anxiety, depression and quality of life.	Recruitment completed	Intervention	2019-04-11	<NULL>	<NULL>	3821	Effect of a complementary practice based on comedy films during hemodialysis in the levels of stress, anxiety, depression and quality of life.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-9pjkgw	<NULL>	be over 18 years old; being on hemodialysis for at least three months at the clinic, performing the procedure three times a week.	Patients who do not agree to participate in the study; those with acute renal disease; patients who find it difficult to understand the issues of the instruments; patients who do not carry out routine hemodialysis follow-up at the reference center (they are hemodialising eventually due to displacement or other need) and patients who do not present stable clinical conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-964r2d	Acute Effect of Coffee Intake on Blood Pressure and Endothelial Function in Uncontrolled Hypertensive patients.	Recruiting	Intervention	2020-01-13	<NULL>	<NULL>	3822	Acute Effect of Coffee Intake on Blood Pressure and Endothelial Function in Uncontrolled Hypertensive patients.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-964r2d	<NULL>	Age between 40 and 65 years; both sexes;With body mass index (IMC) between 20 and 35 Kg/m2; diagnosis of arterial hypertension in treatment Regular with antihypertensive for at least 4 weeks; resenting systolic 140 mmhg and/or diastolic PA 90 mmhg	"will be excluded
Patients with evidence of hypertension
Secondary In use of blockers, statins, nutritional supplements or replacement therapy
Hormonal With PA 160/100 mmHg; You don&apos;t
Consume coffee habitually or present excessive consumption (&gt; 4 cups tea/day); Smokers
Presenting coronary disease clinically
Evident, diabetes mellitus, prior history of acute infarction and/or myocardial revascularization, clinical signs
Heart failure, arrhythmia or
Significant valve disease, previous stroke, thyroid function changes, disease
Renal or liver chronicles and history of
Cancer for the last five years."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-44ys9m	Vocal training with tongue vibration exercise in women	Data analysis completed	Intervention	2020-05-08	<NULL>	<NULL>	3823	Periodized Vocal Training with sound tongue trills technique in women with vocal complaints: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-44ys9m	<NULL>	age between 18 and 45 years; without laryngeal lesions found by ENT examination; vocal or laryngeal complaints after using the voice	participants who were unable to perform the tongue vibration technique; who had a clinical history of neurological, endocrine, metabolic, syndromic and or psychiatric diseases; allergic and / or respiratory crises or hormonal changes; pregnancy; smokers; history of laryngeal and / or pulmonary surgery, who underwent speech and / or otorhinolaryngological treatment due to vocal problems; hearing complaints	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-35dtsg	Body image, self-compassion and self-esteem in young university students: A preventive intervention	Not yet recruiting	Intervention	2020-05-08	<NULL>	<NULL>	3824	Body image, self-compassion and self-esteem in young university students: A preventive intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Cristiany Seppe Faria	Universidade Federal de Juiz de Fora campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-35dtsg	<NULL>	As criteria for inclusion of participants, it is pointed out to be regularly enrolled in a higher course at the IFMG of Governador Valadares; and be between 18 and 35 years old.	"Individuals who indicate a recent diagnosis and / or treatment (last 12 months) of severe psychopathologies (psychosis, risk or attempted suicide, panic disorder and post-traumatic stress disorder) will be excluded.
Individuals who do not participate in all proposed steps (pre-intervention assessment; intervention; post-intervention assessment; and two-week post-intervention assessment) will be excluded.
And participants who demonstrate that they are not attentive to the proper completion of the instruments will be excluded, being classified as random respondents through low scores on the Conscious Respondents Scale (MARJANOVIC et al., 2014)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-3wyxrq	Study of three ways of bonding braces to the teeth	Recruitment completed	Intervention	2020-05-08	<NULL>	<NULL>	3825	Comparison between three ways of orthodontic appliance bonding to teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-13	Carolina Ribeiro Starling	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3wyxrq	<NULL>	Eighteen to thirty years old patients, of both sexes, with normal general health conditions and complete permanent dentition except third molars, with normal anatomy, will be admitted to the research. There should be mild malocclusion characterized by an Angle class I molar relationship, with no skeletal and dental changes in the vertical direction, transverse or antero-posterior. The patient may have mild crowding or few diastemas.	Patients with routine use of analgesic, anti-inflammatory, muscle relaxants or anxiolytic drugs, and patients with temporomandibular disorders will be excluded. In addition, patients with anomalous teeth or with large restorations that hinder the visualization of their normal anatomy or a proper bonding. Patients who used antibiotics in the 3 months before the start of the research will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-42dch5	Phenylephrine to prevent pressure drop in obese pregnant women who underwent cesarean section	Recruiting	Intervention	2020-05-08	<NULL>	<NULL>	3826	"Phenylephrine infusion to prevent arterial hypotension in Obese pregnant women
undergoing cesarean section under spinal anesthesia"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-06-01	Hospital Universitário Júlio Muller	Hospital Universitário Júlio Muller	https://ensaiosclinicos.gov.br/rg/RBR-42dch5	<NULL>	Obese pregnant women with a body mass index greater than or equal to 30 Kg / m2 candidates for elective cesarean section under spinal anesthesia, classified in Physical State II to III of the American Society of Anesthesiologists (ASA) who sign the written, free and informed consent.	Age less than 18 years; gestational age less than 37 weeks; hypertensive pregnancy disease, defined as systolic blood pressure (SBP) greater than 140 mmHg or diastolic blood pressure (DBP) greater than 90 mmHg; twinning; intrauterine growth retardation; cardiovascular disease class II above the New York Heart Association; cerebrovascular disease, fetal abnormality and contraindications to spinal anesthesia (e.g., hemodynamic instability, infection at the lumbar puncture site, coagulopathy and spinal neurological disease).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-9k5z3m	Evaluation of transverse changes in patients treated with passive self-ligating brackets	Recruitment completed	Intervention	2020-05-08	<NULL>	<NULL>	3827	Transverse dentoalveolar evaluation using different time intervals in arch changes in patients treated with passive self-ligating brackets	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k5z3m	<NULL>	young people and adults from 12 to 25 years old, male and female, with complete permanent dentition excluding third molars, Class I or Class II Angle occlusion	prosthetic rehabilitation or extensive restorations, carious lesions or enamel fractures, periodontal diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-277xbx	How the maxillary sinus size can influence the speed and quality of bone formation?	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	3828	How the maxillary sinus dimensation can influence the speed and quality of bone formation?	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-11	Faculdade de Odontologia de Araraquara-Unesp	Faculdade de Odontologia de Araraquara-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-277xbx	<NULL>	Bone high &lt; 4 mm	Patients with systemic condition wich contraindicate the surgery (eg .: diabetes mellitus, immune disorders); smokers, intravenous bisphosphonate users; precense of acute infections and chronic recurrent within jaw; use of anti-inflammatory drugs for long period of time; pregnancy; clinical or radiographic signs that indicate the presence of dental-maxillary tumor or infectious lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-772ktp	The effect of Dance Therapy and Free Dance on the psychological aspects of patients with breast cancer	Recruiting	Intervention	2020-05-11	<NULL>	<NULL>	3829	The effectiveness of a Dance Therapy and Free Dance protocol on the psychological aspects of patients undergoing adjuvant treatment for Breast Cancer: o corpo para além da doença	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Vanessa Bellani Lyra	Universidade Do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-772ktp	<NULL>	Women; age group older than 18 years; clinical stage I to III of breast cancer; be in adjuvant treatment with hormone therapy; be resident in the cities of Florianópolis or São José; present a release from the oncologist responsible for the practice of physical exercise.	Present some orthopedic or neurological limitation that prevents the practice of systematic physical activity; perform combined practice of any physical exercises in order to avoid confusion bias in the face of the intervention; having practiced dance therapy or free dance in the last three months; not be present in at least 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8z2z82	Use of ear acupuncture to help maintain breastfeeding until 6 months of age.	Recruiting	Intervention	2020-05-12	<NULL>	<NULL>	3830	The effectiveness of auricular acupuncture in the duration of exclusive and complementary breastfeeding: a randomized clinical trial”.	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2017-02-01	University of São Paulo at Ribeirão Preto College of Nursing	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8z2z82	<NULL>	Lactating mothers between the fifth and 30th day postpartum; women who have insufficient milk production to the baby&apos;s demands, perception of the mother of low milk production; signs of dissatisfaction of the baby with breast milk; weight loss of the newborn; difficulties to gain weight; need to introduce milk formula as a form of supplement to breast milk.	To make use of galactogogues drugs during the research period;Being a smoker; history of breast surgery (breast reduction surgery or breast implant); never had made the auricular acupuncture before;pregnancy and delivery with any complications; baby who have an weight smaller than 2.500g and larger than 4.000g; twin pregnancy;preterm birth;be allergic to any materials used in auricular acupuncture; make use of other energy therapies (herbal treatments, Reiki, Flower therapy, homeopathy, etc);the patient has no time available to do the treatment;do not have a telephone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4jm343	Effect of Physical Exercise on blood levels of fat and Inflammation of young women using Contraceptives	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3831	Effect of Physical Exercise on the lipid and inflammatory profiles of young women in continuous Oral Contraceptive use	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-10	Grupo Nobre de Ensino Ltda.	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-4jm343	<NULL>	Sedentary women; nulliparous; continued use of combined oral contraceptives for 6 months or more, aged 20 to 30 years.	Hepatic Impairment; diabetes; thyroid dysfunctions; kidney diseases; use of anabolics; alcoholism; smoking; corticoids; use of lipid lowering agents; diuretics; beta-blockers; obesity; polycystic ovary syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8txf7f	Effects of Electroacupuncture on the control of Anxiety in patients undergoing wisdom tooth Extraction	Recruitment completed	Intervention	2020-05-13	<NULL>	<NULL>	3832	Effects of Eletroacupuncture in Anxiety control in patients submitted to Exodontia of third party mollars	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8txf7f	<NULL>	Included in the study were patients with ages ranging from 18 to 60 years; of age who were literate and in possession of the mental faculties; and who wanted to participate in the study; diagnosed with indication for bilateral third molar extraction; asymptomatic and in similar surgical positions and difficulties; analyzed through panoramic radiographs	Patients younger than 18 years of age; classified as ASA III or IV; history of drug use for pain or anxiety within 15 days prior to initiation of the survey; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation or with prior history of pericoronitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-282s2f	Sucess of endodontic treatment in baby teeth using Feapex paste in babies from 1 to 3 years old	Data analysis completed	Intervention	2020-05-14	<NULL>	<NULL>	3833	Effectiveness of pulpectomy in primary molars with Feapex paste containing calcium hydroxide and iodoform: prospective clinical study in babies from 1 to 3 years old	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Faculdade de Odontologia da Universidade de São Paulo	Fundação Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-282s2f	<NULL>	Only children aged 1 year to 3 years and 11 months of age; who presented with primary teeth diagnosed with pulp necrosis or with irreversible pulpitis were included; who completed at least 6 months of clinical and radiographic follow-up were included in the analyses.	The exclusion criteria were as children with systemic and/or neurological diseases; teeth that had dental anomalies, periapical cyst, advanced internal / external resorption (more than 1/3 of the root length), involvement of the permanent successor crypt and presence of less than 2/3 of the root formed in the radiographic examination 21, and teeth that could not be appropriately isolated with rubber dam.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-772thc	Clinical evaluation of the effect of epigallocatechin-3-gallate in the restorative treatment of non-carious lesions	Recruitment completed	Intervention	2020-05-14	<NULL>	<NULL>	3834	Clinical evaluation of the effect of Epigallocatechin-3-gallate in the restorative treatment of Abfraction lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Lisiane Martins Fracasso - Financiamento Próprio	FORP - Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-772thc	<NULL>	"Patients between 18 and 60 years old;
Patients with satisfactory general health and oral hygiene;
Patients who have at least 20 teeth under occlusion;
Presence of at least two abfraction lesions in two homologous premolars;
The lesions must be shallow or medium, involving enamel and dentin;
Teeth must be positive result to the thermal test;"	"Patients with periodontal disease, spontaneous pain and / or tenderness, fistula and / or edema;
Patients with occlusal problems"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-6ynq8f	Effect of a potassium nitrate dentifrice on tooth sensitivity caused by in-office dental bleaching.	Not yet recruiting	Intervention	2020-05-14	<NULL>	<NULL>	3835	Comparative study on the use of toothpaste with 5% potasium nitrate before the whitening process	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	San Francisco of Quito University	San Francisco of Quito University	https://ensaiosclinicos.gov.br/rg/RBR-6ynq8f	<NULL>	This trial will include adults between 18 and 30 years old, regardless of gender, with good dental and periodontal health. Specifically attention will be given to six maxillary anterior teeth, which will be required to be caries-free and without buccal restorations. Shade of central incisors will be required to be A2 or darker in a value-oriented shade guide (VITA EasyShade Advance, Vita Zanhnfabrik).	This trial will exclude participants who have previously undergone tooth-bleaching procedures, dental sensitivity, pregnancy or lactation, and severe tooth pigmentation caused by drugs, fluorosis, or pulpal pathology. Participants will also be excluded if they are taking any form of medication (especially anti-inflammatory drugs), bruxism, enamel cracks, gingival recession, class V cavities, dentin exposure, or any other clinical condition that could cause dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-5rvntq	The efficacy of educational materials to change patients&apos; beliefs about Low Back Pain	Recruitment completed	Intervention	2019-10-01	<NULL>	<NULL>	3836	Are brief educational materials containing information derived from clinical practice guidelines able to change the beliefs of patients with Low Back Pain? A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Rafael Zambelli Pinto	Rafael Zambelli Pinto	https://ensaiosclinicos.gov.br/rg/RBR-5rvntq	<NULL>	Participants with low back pain, regardless of the duration of symptoms; low back pain is defined as pain or discomfort, localised below the costal margin and above the inferior gluteal folds, with or without leg pain; aged 18 years or more; participants receiving or seeking physical therapy treatment for low back pain.	Participants with severe spinal diseases (e.g.: Fractures, tumors, and inflammatory pathologies with ankylosing spondylitis; presence of lumbar radiculopathy (Self-reported pain radiating down below the knee with at least one of the following characteristics: numbness or pins and needles in a dermatomal distribution, weakness and reflex changes in a myotomal distribution); pregnancy; participants who have suspected or confirmed kidney disease; education level below fifth grade.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4w8xn2	Efficacy of Manual Therapy and Therapeutic Exercises in the hands of patients with Systemic Sclerosis - a randomized controlled clinical trial	Recruitment completed	Intervention	2019-06-17	<NULL>	<NULL>	3837	Efficacy of Articular Mobilization and Kinesiotherapy in the functionality of the hands of patients with Systemic Sclerosis - controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Universidade Federal de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-4w8xn2	<NULL>	Diagnosis of systemic sclerosis by rheumatologist; 18 years of age or over; presence of impairment of the functionality of the hand determined by score in Cochin scale greater or equal 10.	Superposition with other autoimmune or inflammatory rheumatologic diseases; presence of scleroderma-like diseases (eosinophilic fasciitis, nephrogenic systemic fibrosis, scleromyxedema); presence of acute arthritis or myositis in activity; presence of ulcers in active hands; presence of amputation in upper limbs; physical therapy in the last three months; difficulty in moving or unable to attend the scheduled treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-4vm3yy	Effect of convalescent plasma in patients with severe COVI-19	Recruiting	Intervention	2020-05-15	<NULL>	<NULL>	3838	Use of convalescent plasma submitted to pathogen inactivation for the treatment of patients with severe COVID-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-19	Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti	Paulo Niemeyer State Brain Institute	https://ensaiosclinicos.gov.br/rg/RBR-4vm3yy	<NULL>	Age &gt; or equal to 18 years; Severe or critical-19 COVID-19; Length of stay &lt; 3 days; Laboratory confirmation of COVID-19 by detection of the viral genome in respiratory secretions, collected by swab; Signature, by the patient or a relative, of the informed consent form	Allergic reactions prior to plasma transfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8648fg	Dose-response effect of strength training on the rehabilitation of patients with Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2020-05-18	<NULL>	<NULL>	3839	Dose-response effect of strength training on the rehabilitation of patients with patellofemoral pain syndrome: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Nathalia Trevisol de Oliveira	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8648fg	<NULL>	Female individuals aged between 18 and 40 years, able to carry out the training and proposed evaluations and who are willing to participate in the study on a voluntary basis after the disclosure of the work on social networks on the internet. The syndrome will be diagnosed by a physiotherapy professional with experience in managing this patient profile, based on the criteria of the American Phisycal Therapy Association guidelines consensus: presence of retropatellar or peripatellar pain; pain reproduction during the squat; performance of other functional activities such as sustained knee flexion, going up or down stairs, kneeling, running.	Presence of musculoskeletal injuries in the lower limbs that prevent or impair the performance of exercises and assessment; history of physical trauma involving the knees or lower limbs, such as traffic accidents, falls, bruises, in the last twelve months; body mass index (BMI)&gt; 30; having performed a rehabilitation protocol for patellofemoral pain syndrome up to six months before data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-74683n	Efficacy of aerobic training in individuals with Parkinson&apos;s disease	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	3840	Efficacy of aerobic training in immunological and neurotrophic parameters and in clinical measures in subjects with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-20	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-74683n	<NULL>	"Have clinical diagnosis of idiopathic PD according to the criteria of clinical diagnosis of the
United Kingdom Parkinsons Disease Society Brain Bank (Hughes et al., 1992);
Age above 40 years;
To be in stage 1,5 to 3 of Hoehn &amp; Yahr;
Be in use of l-dopa and clinically stable;
Being able to wander independently or with the use of auxiliary devices;
Have medical release for performing aerobic training."	"To have impairment of cognitive function according to the score of the Mini-Exam of the Mental State
(cut-off point 13 for illiterate, 18 for low and medium schooling and 26 for high
schooling);
Have intense dyskinesia that interferes with postural stability;
Have other neurological and psychiatric diseases;
To present musculoskeletal changes that make difficult the accomplishment of the exercises;
To present rheumatologic diseases that interfere in the concentration of mediators
inflammatory drugs;
Have an unstable cardiovascular condition."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-276rrt	Effects of Supplementation of a Component Present in Apples in Menopausal Women with Metabolic Syndrome	Recruitment completed	Intervention	2020-05-18	<NULL>	<NULL>	3841	Effects of Ursolic Acid Supplementation Associated with a Physical Activity and Nutritional Program in Women with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-276rrt	<NULL>	be female; history of spontaneous amenorrhea for a period greater than or equal to 12 months; age between 45 and 70 years; having waist circumference greater than 80 cm associated with two more parameters; fasting blood glucose greater than 100 mg/dL; triglycerides greater than 150 mg/dL, HDL-cholesterol greater than 50 mg/dL; blood pressure greater than 130/85 mmHg or use of antihypertensive drugs.	pregnant or breastfeeding women; who have musculoskeletal disorders that compromise body movement; or some serious heart disease; history of drug and alcohol abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8yyzzz	Anesthetic Effect of Articaine 2% with Epinephrine 1: 200,000 with Sodium Bicarbonate in Maxilla Infiltration	Recruiting	Intervention	2020-05-18	<NULL>	<NULL>	3842	"Effect of Alkalinization of the 2% Articaine Hydrochloride Solution with Epinephrine 1: 200.000 on anesthetic efficiency in infiltration in the maxilla
Crossover randomized clinical trial"	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2019-02-14	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8yyzzz	<NULL>	Healthy individuals; age between 18 and 45 years; similar level of education, from incomplete third grade; previous experience of local anesthesia; absence of history of complications resulting from local anesthesia; presence of healthy maxillary incisors, canines and premolars	Pregnant women; infants; volunteers with systemic impairment that contraindicate anesthesia; volunteers who present a history of allergic reaction to any component of the anesthetic solutions used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-6rv7qw	Suggestions for Food and Nutrition Education Activities that Promote Child Development	Recruitment completed	Intervention	2020-05-18	<NULL>	<NULL>	3843	Proposal of Activities in Food and Nutrition Education to Stimulate Child Development	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-08-01	Telma Maria de Menezes Toledo Florêncio	Centro de Recuperação e Educação Nutricional - CREN	https://ensaiosclinicos.gov.br/rg/RBR-6rv7qw	<NULL>	female volunteers; with 6 and 24-month-old son; without moderate or severe child malnutrition, height standard deviation for age greater than -2; without moderate or severe childhood anemia; hemoglobin above 10g / dL; residents of socially vulnerable communities close to CREN.	Female volunteers with psychiatric disorders, children with neuropsychomotor disabilities; children with physical disabilities that make anthropometry impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-62y3h7	Acute impairment of renal function in COVID-19: study on incidence, risk factors and mortality	Recruiting	Observational	2020-05-18	<NULL>	<NULL>	3844	Acute Kidney Injury in Infectious Coronavirus Disease: a study on incidence, risk factors and mortality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-62y3h7	<NULL>	suspected diagnosis of COVID-19	negative test for COVID-19; patients without diuresis control or at least two creatinine tests during hospitalization; pregnant women; age under 18; patients with advanced CKD (Cl Cr &lt;30 ml / min; kidney transplant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5944yh	Maintenance of Post-Extraction alveolar sockets with Buccal Bone Defect	Recruiting	Intervention	2017-11-24	<NULL>	<NULL>	3845	Maintenance of Post-Extraction Alveolar Sockets with Vestibular Bone Defect	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-02	Faculdade de Odontologia de Araraquara-Unesp	Faculdade de Odontologia de Araraquara-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-5944yh	<NULL>	Good oral hygiene with plaque index less than 20%; presence of teeth adjacent to the tooth to be extracted with harmonical gingival architecture; age between 18-65 years; clinical attachment level in the vestibular sites &gt; 3 mm.	"history of periodontal surgical procedures in the surgical site; Presence of systemic impairment that makes it impossible to carry out the surgeries; presence of infection involving the gingival margin; smokers,
bruxism, alcoholics, drug users, diabetics, pregnants, History of radiotherapy
in the head and neck region, users of medications that may interfere with the
bone remodeling, presence of pathologies that affect bone metabolism."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-2spcx5	Evaluation of the bone formation in the midpalatal suture after low level laser irradiation	Data analysis completed	Intervention	2020-05-19	<NULL>	<NULL>	3846	“In vivo evaluation of the osteoinductive action of low-power laser on bone formation of the median palatal suture after rapid maxillary expansion	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-04-25	School of Dentistry of Ribeirão Preto	School of Dentistry of Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2spcx5	<NULL>	Age between 6 to 12 years old; both genders; patients in mixed dentition; skeletal maxillary hypoplasia; crossbite greater than 4 mm; intermolar distance smaller than 31mm; upper first permanent molars fully erupted	Patients with dark pigmentation on the palate region; patients with systemic abnormalities; patients with special needs; presence fo dental malformations; patients with high risk for dental caries; high dental caries activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-7r2r7n	Investigation of adherence to eyedrops in patients with glaucoma	Recruiting	Intervention	2020-05-19	<NULL>	<NULL>	3847	Investigation of adherence to treatment in patients with glaucoma	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-24	Allergan	Allergan	https://ensaiosclinicos.gov.br/rg/RBR-7r2r7n	<NULL>	Will be included in the glaucoma group: patients older than 18 years and one day ; the patients with glaucoma, defined by the presence of optic neuropathy with glaucoma typical changes (optic disc excavation greater than 0.6, optical disc excavation asymmetry greater than 0.2, atrophy of the nerve fiber layer, localized loss of the neuroretinal rhyme) , and with changes in the white to white perimetry examination; patients taking at least one hypotensive eye drop.	Patient under 18 years of age; those who have not yet been diagnosed with confirmed glaucoma; patients unable to respond to the questionnaire applied.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-8rtjmd	Effects of exergames and traditional exercise on anxiety in women after exposure to unpleasant stimuli	Not yet recruiting	Intervention	2020-05-19	<NULL>	<NULL>	3848	Acute Effects of Exergames and Traditional Continuous Exercise on Anxiety-State Levels in young women after exposure to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rtjmd	<NULL>	woman; aged between 18 and 40 years old	Body mass index equal or greater than 30 kg/m2;  to be in the menstrual period; to have contraindications for physical activity; to be undergoing any kind of anxiolytic treatment; to be illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3jx5n7	Analysis of the Mobility of patients hospitalized in the ICU submitted to Physiotherapy in relation to Perme Escore	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	3849	Analysis of the Mobility of critical patients submitted to Physiotherapeutic Intervention in relation to Perme Escore	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3jx5n7	<NULL>	Patients hospitalized in the adult ICU of the HC-UFU; older than 18 years; with MRC (muscle strength rating scale) between 36 and 48 points; hemodynamically stable.	Patients younger than 18 years; hemodynamically unstable; without muscular weakness acquired in the ICU; MRC greater than 48 points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-8mgc3h	Motivational Interview and text messaging post-discharge for support for smoking quit	Data analysis completed	Intervention	2019-03-11	<NULL>	<NULL>	3850	Motivational Interview and text messaging post-discharge for supporting tobacco use cessation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-29	Universidade Federal de Juiz de Fora	HOSPITAL UNIVERSITÁRIO - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-8mgc3h	<NULL>	Aged 18 years or older. Smoked cigarettes in the last 30 days (even a puff). Have own mobile phone. Have received at least one text message in the last year. Have no problem with the mobile phone signal.	Don’t have a mobile phone. Unstable cognitive or physical condition. Physical or breath contact restrictions. Intensive care units.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-8jd639	Development of a prospective data registry system for urinary incontinence patients	Recruiting	Observational	2020-05-20	<NULL>	<NULL>	3851	Epidemiological and demographic data collect from women Urinary Incontinence	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-12-12	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8jd639	<NULL>	Women with urinary incontinence; referred to the voiding dysfunction sector of the Urology discipline	children; pregnant; women with severe cognitive impairment; patients with severe psychiatric conditions; vesicovaginal fistula; bladder stones; urethral cysts, bladder cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3xdf4k	Efficacy of a multimodal exercise training associated with whole body vibration at falls  risk and quality of life in older adults	Recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3852	Efficacy of Multicomponent Training associated with Whole Body Vibration on falls risk and quality of life in osteoporotic older adults : randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3xdf4k	<NULL>	The inclusion criteria are : olders adults (ages 60 -80 years)with osteoporosis (bone densitometry) ; Previously trips or falls ;  medical statement for exercise ( cardiologist) and no participating in other activities	Neurological disease; Epilepsy; Cognitive deficit; Severe visual impairment; Circulatory diseases; Amputation or use of lower limb prosthesis (MMII); History of recent fracture in lower limbs; Hernia, discopathy or severe spondylosis and neoplasia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-4s5nkh	Assessment of gait biomechanics and quality of life of individuals with unilateral lower limb amputation	Recruitment completed	Intervention	2020-05-20	<NULL>	<NULL>	3853	Energy expenditure, gait and Quality of Life assessment of individuals with Transtibial and Transfemoral Amputation undergoing rehabilitation protocol: pre and post prosthesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-06	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4s5nkh	<NULL>	"Individuals with amputations fit for prosthesis;
Amputation levels: unilateral transfemoral and transtibial;Prosthetized individuals who will be protected by the Unified Health System (SUS) of the
of Orthosis and Prosthesis of the Clinical Hospital of the State University of Campinas; Individuals of both sexes;Individuals aged 18 to 60 years;sedentary individuals;Individuals enjoying full intellectual ability"	"Individuals with different amputation levels than those mentioned in the inclusion criteria;
bilateral amputations;Individuals considered unfit for prosthetization;athletes;Individuals with any infection or with absolute medical restriction;intellectually incapable individuals"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5k95vs	Effectiveness of TENS associated with vocal therapy in women with vocal disorders	Not yet recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3854	Effectiveness of the application of low-frequency transcutaneous electrical nerve stimulation associated with vocal therapy in dysphonic women: clinical trial, controlled, randomized and blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5k95vs	<NULL>	women aged between 18 and 50 years old; complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	women who had received speech therapy before;  over 50 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-6649b2	Effects of physical exercise in the fadigue of the patient with heart and lung disease	Recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3855	Evaluation of fadigue of the patient with heart and lung disease undergoing physical exercise	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-06-02	Universidade Federal do Rio de Janeiro	ICES - Instituto do Coração Edson Saad	https://ensaiosclinicos.gov.br/rg/RBR-6649b2	<NULL>	"Group 1 (COPD): patients in this group will be selected based on the presence of the forced expiratory volume in the first second (FEV1) less than 60% of the predicted; with FEV1 / forced vital capacity (FVC) ratio less than 70%; who have symptoms of dyspnea on clinically stable efforts.
- Group 2 (CHF): patients must have documented heart failure in the last 6 months; with echocardiography showing an ejection fraction of less than 45% within the last 6 months; with classification between I-II of the disease according to New York Heart Association45; clinically stable and without episodes of hospitalization in the last month, non-smokers; non alcoholics; non-drug users who cause chemical dependency; who do not have COPD (FEV1 / FVC and FEV1 &lt;70% of predicted) or unstable angina; or history of myocardial infarction in the last 6 months; or inability to exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
- Group 3 (control): volunteers in this group will be selected because they are in good general health; in the absence of abnormalities in the cardiovascular, respiratory or musculoskeletal system and metabolic changes; sedentary (weak classification by the American Heart Association44)"	"Group 1: no absence of hypoxemia, ex-smokers; who do not have right heart failure; non alcoholics; non-drug users who cause chemical dependency; and who do not have an inability to perform the exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
Group 2: non-smokers; non alcoholics; non-drug users who cause chemical dependency; who do not have COPD (FEV1 / FVC and FEV1 &lt;70% of predicted) or unstable angina; or history of myocardial infarction in the last 6 months; or inability to exercise due to neuromuscular or musculoskeletal disorders; as well as other potential causes of fatigue.
Group 3: should not be smokers; drinkers; drug users who cause chemical dependency; without diabetes melitus, dyslipidemia and arterial hypertension; non-users of antihypertensive and cardioactive medications."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-6dyvm4	Arthrocentesis associated with infiltration of hyaluronic acid or platelet-rich plasma improve interincisal mouth opening and painful  in the region of  temporomandibular joint	Recruiting	Intervention	2020-05-21	<NULL>	<NULL>	3856	Does arthrocentesis associated with infiltration of hyaluronic acid or platelet-rich plasma improve interincisal mouth opening and painful symptoms in temporomandibular joint disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6dyvm4	<NULL>	patients between 18 and 67 years old; diagnosed with arthralgia, disc displacement or degenerative joint diseases;with a minimum of 4 points on the visual and numerical analogue pain scale (NAVS) in the articular region; maximum interincisal opening less than or equal to 35 mm.	previous history of TMJ surgery; indication for surgical treatment; systemic conditions involving ATM;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-4f9cdj	Clinical study to evaluate efficacy, safety and disease-free time with low-dose Oral Isotretinoin compared to Doxycycline in the treatment of papule pustular Rosacea	Recruitment completed	Intervention	2020-05-21	<NULL>	<NULL>	3857	Clinical trial to evaluate efficacy, safety and time of remission of Oral Isotretinoin in low dose compared to Doxycycline Hydrochloride in the treatment of papule pustular Rosacea	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-11-12	Universidade Federal De São Paulo - UNIFESP	Universidade Federal De São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4f9cdj	<NULL>	Signature of the Free and Informed Consent Form (ICF) and Authorization Form for Photography before any study procedure; men or women aged between 20 and 75 years old, in good health; clinical diagnosis of papular pustular rosacea, with or without ocular involvement, with or without the presence of phyma, and who have been in the active phase of the disease for at least 1 month before the date of inclusion; participants must present on the day of inclusion at least 6 active lesions on the face (papules or pustules), that is, a score greater than or equal to 3 of the static score of 8 points for global assessment of rosacea by the investigator (Investigator&apos;s Global Assessment of Rosacea: 8 Point Static Score); absence of topical or systemic treatment, except sunscreens, for at least 3 months; absence of antibiotic therapy (cyclins, macrolides, metronidazole, azalides), for any reason, for at least 3 months; absence of previous treatment with oral isotretinoin or other systemic retinoid; absence of chemotherapy in the last 3 months; absence of a history of hypersensitivity to the study drugs; absence of infectious or other inflammatory dermatoses on the face; absence of clinical evidence or personal history of immunosuppression; absence of habit of drinking alcoholic beverages; absence of photodermatosis; absence of a previous or current history of collagen diseases; agreement to avoid sun exposure throughout the study and agreement with the conditions of the study, ability to understand and strictly follow the guidelines received and availability to attend periodic reevaluations.	Men and women who do not agree with the conditions of the study or without the ability to understand and strictly follow the guidelines received, without availability to attend periodic reevaluations or who refuse to sign the ICF; pregnant or lactating women; women of childbearing age and with sexual activity who refuse to use any method of contraception, such as oral, implantable, injectable or intrauterine contraceptives, introduced at least 120 days after the start of treatment; participant with exclusively phymatous rosacea (type 4); report of abuse of alcoholic beverages and / or illicit drugs; topical or systemic treatment, except sunscreens, for less than 3 months; use of antibiotic therapy (cyclins, macrolides, metronidazole, azalides), for any reason, for at least 3 months; previous treatment with oral isotretinoin; history of non-adherence to previous clinical treatments; previous or current history of collagen diseases; clinical evidence or history of immunodeficiency; use of any immunosuppressive and, or immunomodulatory medication in the last 3 months, topical or systemic; chemotherapy in the last 3 months; history of inflammatory bowel disease or regional enteritis and / or similar symptoms and any clinical observation made by the investigator that prevents participation in the study; presence of significant hepatic laboratory alterations, that is, values of transaminases 2 times above the upper limit of normality; diabetic patients, with fasting blood glucose values above 110mg / dl; presence of significant lipid changes (triglycerides above 300 mg / dl; total cholesterol above 250 mg / dl); presence of leukopenia (leukocytes under 3000 / mm3); history of hypersensitivity to isotretinoin and parabens or doxycycline hydrochloride; previous history of hypervitaminosis A; previous history of bone and or muscle changes and patients in use or who may need the following medications, for systemic use, due to the risk of interaction with the study drug: vitamin A or vitamin complexes with vitamin A up to 30 days ago; carbamazepine up to 7 days ago and cyclin class antibiotics up to 30 days ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9hgn6v	Performance of the speech therapist in the Rehabilitation of Postural Balance	Recruitment completed	Intervention	2020-05-21	<NULL>	<NULL>	3858	Speech Therapy Performance in Vestibular Rehabilitation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Universidade Federal do Rio Grande do Norte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9hgn6v	<NULL>	Adult or elderly patients; of both sexes; diagnosed with unilateral peripheral vestibular hypofunction; with a history of dizziness, postural imbalance and/or falls.	Neurological, neoplastic, severe visual, psychiatric diseases or changes in the cervical spine that made it impossible or difficult to conduct the interview, apply the questionnaire and/or perform the therapy; diagnosis of benign paroxysmal postural vertigo.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-7f62gv	Treatment for Lower Back Pain through the Laser and waves-short	Recruitment completed	Intervention	2020-05-05	<NULL>	<NULL>	3859	Association of low power laser and shortwave diathermy in non-specific low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7f62gv	<NULL>	To participate in the study; patients must be over 18 and less than 80 years; with lumbar pain at least 3 months; without any cognitive impairment that may interfere with the performance of tasks and signing the consent form.The sample size is comprised of 10 subjects per group	Patients who have undergone surgical procedures in the lumbar spine (arthrodesis); pregnant women; people who have a diagnosis of cancer; women with IUD (intrauterine device); patients who are uncooperative or cognitive ability to achieve the clinical procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5t399r	Single visit x multiple visit endodontic treatment: success after 1 year of treatment	Data analysis completed	Intervention	2018-03-27	<NULL>	<NULL>	3860	"Quantification of endotoxins and its relation with signs and symptoms: single  X
multiple-visits - one year follow-up by CBCT analysis"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	ICT Instituto de Ciência e Tecnologia - Unesp de São José dos Campos	FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5t399r	<NULL>	Unirradicular teeth with presence of pulp necrosis and periapical lesion and absence of previous endodontic treatment were included in the study in patients with favorable health conditions.	The authors excluded teeth with periodontal disease, root fracture, exposure of the pulp chamber, patients who used antifungals and antibiotics in the period of three months before the endodontic treatment, impossibility of absolute isolation and paper points insertion in the root canal  working length.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-7qt7vk	The role of Nasal Irrigation with Anti-inflammatory in patients with Chronic Sinusitis never operated	Recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3861	The role of Nasal Irrigation with Corticosteroids in the control of Chronic Rhinosinusitis in the preoperative period: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qt7vk	<NULL>	"Older than 18 years;
Rhinosinusitis without polyps or rhinosinusitis with polyps, according to the EPOS 2012 research criteria;
Never submitted to nasal or nasosinusal surgery;
Indication of surgical treatment due to failure to initial routine clinical treatment."	"Inability to answer the questionnaires;
Pregnant or lactating women;
Absolute contraindication to the use of corticosteroids;
Previous diagnosis of immunodeficiencies;
Previous diagnosis of nasosinusal neoplasms;
Previous diagnosis of primary ciliary dyskinesias;
Previous diagnosis of cystic fibrosis;
Use, in the 30 days prior to the inclusion in the study, of oral, intramuscular or intravenous corticosteroids."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3z3w3n	Effects of probiotic use in diabetic patients with periodontal disease	Not yet recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3862	Analysis of the clinical profile of diabetic patients with periodontitis before and after probiotic therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3w3n	<NULL>	Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade C periodontitis, with more than 30% of the sites with probing depth and clinical level of insertion greater than or equal to 4 mm and bleeding on probing of at least 30% of the teeth; presence of type II diabetes mellitus diagnosed at least 5 years ago, with glycated hemoglobin levels between 7% and 11%, treatment with diet and supplementation with insulin or hypoglycemic agents; presence of a good state of general health with the exception of diabetes mellitus.	Presence of other systemic conditions, with the exception of diabetes mellitus, which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation; diabetic complications, such as nephropathy, neuropathy, and peripheral cardiovascular and vascular diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9x2fwc	Evaluation of the patency of diverse types of accesses for hemodialysis in the hospital of clinics of UFMG. Long term study.	Recruiting	Observational	2020-05-22	<NULL>	<NULL>	3863	Evaluation of the patency of diverse types of accesses for hemodialysis in the hospital of clinics of UFMG. Prospective study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade Federal de Minas Gerais - UFMG	Pró Reitoria de Pesquisa UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9x2fwc	<NULL>	Patients over 18 years of age who underwent arteriovenous access for hemodialysis. Chronic renal failure, estage 3 or 4. Agree and sign the informed consent form.	Patients who disagree or do not sign the informed consent form. Under 18 years old. Patients undergoing reintervention in access for hemodialysis. Patients on peritoneal dialysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9g8585	Effect of manual therapy on the autonomic nervous system in chronic pain	Recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3864	Effect of manual therapy on the vagus nerve pathway in the cardiac autonomic nervous system in individuals with chronic musculoskeletal pain: a controlled and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Pedro Teixeira Vidinha Rodrigues	Pedro Teixeira Vidinha Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-9g8585	<NULL>	musculoskeletal pain for more than 3 months in any segment of the body and that fails the conditioned pain test by the cold pressor test.	individuals under 18 or over 60; who have a surgical procedure in the chest / spine region that prevents performing the proposed techniques; pregnant women; present rheumatological diagnosis in acute inflammatory phase; osteoporosis, primary bone tumors or not; presenting lymphedema in any member; having a pacemaker, having a cardiac arrhythmia or having a heart transplant; having eaten food and drinks containing caffeine on the day of the experiment; having drunk alcohol in the last 24 hours; use medications with a cardiac effect; unable to complete the self-administered questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-7wx8fy	Evaluation of the use of Laser Therapy on the decrease of microorganisms on dental plaque	Data analysis completed	Intervention	2020-05-22	<NULL>	<NULL>	3865	"Use of Photodynamic Therapy in the Microbiological Remission of Supragingival
Biofilms adhered to dental surface"	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-02	Faculdade de Odontologia de Ribeirão Preto/Universidade de São Paulo - FORP/USP	Faculdade de Odontologia de Ribeirão Preto/Universidade de São Paulo - FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-7wx8fy	<NULL>	Healthy volunteers; both genders; non smokers; age 10 to 40 years old; presence of dental plaque on dental surface	Were excluded volunteers diagnosed with any systemic diseases; syndromes; pregnant and lactating women; or who made usage of medicines that alter the salivary flow	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-8nhtpf	Randomized clinical trial of Physical Activity and Yoga and Meditation to reduce Stress: implications on Cardiovascular Risk and Laboratory Tests	Recruitment completed	Intervention	2020-05-22	<NULL>	<NULL>	3866	Randomized clinical trial of Physical Activity and Meditation for Stress reduction: implications for Cardiovascular Risk and Biomarkers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-05	Fundação Universitária de Cardiologia de Porto Alegre	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-8nhtpf	<NULL>	The research included those who signed the Free and Informed Consent Form; age over 18 years; those who attended the University for more than 6 months in health courses; Those who obtained high stress scores according to the psychometric instruments used	Those who practiced regular physical activity or Yoga and meditation were excluded; those undergoing formal treatment for stress and anxiety; heart disease carriers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-9bkvx3	Pain, functions of daily living activities and weakness in patients at a Physiotherapy clinic after a Pain Education Program	Recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3867	Pain, functionality and fragility of Physiotherapy service users submitted to a Pain Education Program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual do Centro-Oestre	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-9bkvx3	<NULL>	Patients treated at the Clinical School of Physiotherapy (CEFISIO) at UNICENTRO; age between 18 and 80 years; both genders; carry the signed free and informed consent form (ICF); musculoskeletal pain greater than 3 months; having access to ICT’s (internet, applications for text message communication and video conferencing)	dementia; not verbalize; not performing pre and post intervention assessments; miss more than one CBT meeting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-5kyg2r	Effectiveness of Betamethasone versus Triamcinolone injection in the treatment of Alopecia	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3868	Effectiveness of intralesional Betametasone versus Triancinolone Acetonide in the treatment of Alopecia Areata	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-24	Universidade Federal do Ceará, Campus Sobral	Universidade Federal do Ceará, Campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-5kyg2r	<NULL>	both genders; age between 18 and 60 years; clinical diagnosis of localized alopecia areata, with less than 25% area of hair loss; presence of an alopecia patch with a larger diameter between 2 and 5 cm	any form of therapy for alopecia areata in the past 3 months; use of systemic corticosteroids or immunosuppressive drugs; illness or condition that causes immunosuppression; rapidly progressive disease; presence of another cause of alopecia; presence of an inflammatory process in the alopecia patch; history of allergy to corticosteroids; pregnancy or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2jnx4s	Effect of ear acupuncture on nursing professionals with stress, anxiety and depression	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3869	Effectiveness of auriculoacupuncture on stress, anxiety and depression in nursing professionals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2jnx4s	<NULL>	Nursing professionals with moderate, severe and extremely severe levels of stress, anxiety and depression, assigned to each sector, with availability to answer questions and scale and participate in the intervention, if selected.	Individuals with infection, inflammation or injury in the ear, use of ear piercing (except for normal earring), allergy to metal or microporous tape; subjects who have some PIC for anxiety, stress and / or depression, being pregnant, being in the puerperium and / or breastfeeding; refuse to receive ear treatment using needles.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-94pj2d	Effectiveness of computed tomography in face fracture diagnosis	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3870	Effectiveness of computed tomography with three-dimensional reconstruction in the diagnosis of panfacial fractures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-94pj2d	<NULL>	Suspected fractures of the middle third of the face requiring computed tomography for diagnostic purposes.	Patients referred with CT already performed in another hospital and patients with a past history of facial fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-9b78kj	Effect of Acai consumption on variables related to muscle damage induced by exercise in active individuals.	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3871	Effect of consumption of Acai (Euterpe oleracea Mart.) on late pain, recovery and exercise-induced muscle damage: clinical, randomized, crossover, double-masked, and controlled placebo study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9b78kj	<NULL>	Age between 18 and 50 years; practice physical exercise for at least six months; and be available to participate in the study.	present intolerance / aversion to açaí; use alternative treatments to reduce late pain (acupuncture, cryotherapy, anti-inflammatory drugs, analgesics, among others); you are a smoker; present a weight change greater than 10% in the last three months; have chronic (cardiovascular, renal, liver, intestinal), infectious, inflammatory or acute illnesses that have required treatment in the past two months; having had cancer in the past ten years; chronic use of medication, except contraceptives; make use of anabolic steroids; use nutritional supplements, except supplements based on carbohydrates and proteins; is in gestational or breastfeeding period; has undergone surgical intervention to treat obesity; and is not available to participate in the meetings regarding the intervention and data collection of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2s29md	Effects of Non-Invasive Ventilation During Sleep in Patients with Chronic Obstructive Pulmonary Disease (COPD)	Data analysis completed	Observational	2020-05-25	<NULL>	<NULL>	3872	Acute effects of Noninvasive Ventilation on sleep physiology in patients with stable moderate to severe Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s29md	<NULL>	Adult patients; over 40 years old; diagnosed with COPD by spirometric criteria, classified as moderate or severe; with stable disease characterized by the absence of exacerbation for more than 2 months; with absence of other pulmonary, cardiovascular, renal and neurological morbidities; and who signed the informed consent form	Patients who did not complete the study protocol; and who did not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2gbqfx	Study on the correct use of drugs in patients with infarction	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3873	Medication adherence in patients with a history of Myocardial Infarction: randomized clinical trial	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2020-08-03	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2gbqfx	<NULL>	Patients with myocardial infarction; both genders; age over 18 years; using cardioprotective drugs; social referent responsible for organizing and taking pills	Patients without conditions for effective oral verbal communication; diagnosed with mental disorders; social referent who cannot be present in the interviews	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-34zqrc	Effect of laser in the functional of temporomandibular joint	Recruitment completed	Intervention	2020-05-25	<NULL>	<NULL>	3874	Effect of low-level laser therapy in the functional of temporomandibular joint	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Piauí	Grupo de Pesquisa em Fisioterapia Avaliativa e Terapêuticas - GPFAT	https://ensaiosclinicos.gov.br/rg/RBR-34zqrc	<NULL>	young adults enrolled in the clinical sector of the physiotherapy school; age between 18 and 25 years; regardless of gender; agreed to participate in the study by signing the informed consent form.	individuals wearing a fixed or mobile orthodontic appliance; use of correction board; use of anti-inflammatory or muscle relaxants; with another pathogen that altered TMJ functionality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-3cjbq5	Microneedling effect on male baldness.	Not yet recruiting	Intervention	2020-05-26	<NULL>	<NULL>	3875	Randomized comparative single blinded clinical trial on the effectiveness and safety of microneedling in the treatment of androgenetic alopecia.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Hospital São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3cjbq5	<NULL>	Signature of Written Informed Consent Form and Authorization for Photographs Term prior to any study procedure; men aged between 18 and 60 years, in good health; Clinical diagnosis of moderate male androgenet alopecia (Stage IIIa-IV of the Norwood-Hamilton Scale) with disease onset time less than 10 years; accordance with the conditions of the study, ability to understand and strictly follow the therapeutic guidelines received and availability to attend periodic evaluations.	Men who do not agree with the conditions of the study or who are unable to understand and strictly follow the therapeutic guidelines received, are not available to attend periodic evaluations or refuse to sign the Written Informed Consent Form and Authorization for Photographs Term; patients suffering from other alopecias, including telogen effluvium; patients with mild disease (stages I and II) or severe disease (stages V to VII of the Norwood-Hamilton Scale); patients who have androgenetic alopecia for more than 10 years; previous use of finasteride or dutasteride in the last 6 months; patients with a current or previous history of malignant or pre-malignant tumors of the scalp; patients that suffer from allergic contact dermatitis to propylene glycol (minoxidil vehicle), minoxidil, tattoo ink, topical or local anesthetic; patients that have dermatoses that may worsen due to the procedure and interfere with the evaluation, such as psoriasis, vitiligo; patients receiving chemotherapy, radiation therapy, corticosteroids or other immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-99h7tc	Monitoring of antibiotic treatment of patients with suspected sepsis using the biomarker Procalcitonin	Recruitment completed	Intervention	2020-05-26	<NULL>	<NULL>	3876	Procalcitonin-guided Antibioticotherapy in critical patients with suspected Sepsis in a university hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal de Sergipe	Hospital Universitário de Lagarto	https://ensaiosclinicos.gov.br/rg/RBR-99h7tc	<NULL>	Patients with suspected sepsis; hospitalized in critical areas (yellow, red clinic and ICU); Older than 18 years; Not pregnant.	Pregnancy discovered during collection; infections requiring prolonged antibiotic therapy, such as endocarditis, liver or brain abscess, deep abscess, mediastinitis and osteomyelitis; severe infection caused by viruses, parasites, fungi or mycobacteria; negative cultures (blood, urine, tracheal aspirate, or bronchoalveolar lavage) in patients with suspected sepsis, severe sepsis or septic shock.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-4bs5xs	Assessment of dentalarch space maintenance after the early extraction of the baby tooth	Recruiting	Intervention	2020-05-26	<NULL>	<NULL>	3877	Assessment of dental arch space maintenance after deciduous molar early loss: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4bs5xs	<NULL>	Age between 6 and 9 years of age; without systemic involvement; both sexes; clinical and radiographic indication of tooth extraction of upper or lower deciduous molar; voluntary; authorization of caregivers.	Presence of craniofacial syndromes or abnormalities; Anodontia of the permanent successor; Early loss of the deciduous canine; Multiple losses in the arch of the tooth to be extracted;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-6rhn6r	Quality of automatic blood pressure monitors to measure blood pressure in adults	Recruitment completed	Intervention	2020-01-25	<NULL>	<NULL>	3878	Accuracy of oscillometric blood pressure measurement in adults: analysis in ideal and non-ideal conditions of measurement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-12	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-6rhn6r	<NULL>	Volunteers over the age of 18; both genders.	Volunteers reporting cardiac arrhythmia of any nature, acute or chronic kidney disease, and / or pregnancy at the time of data collection; arm circumference between 27 and 34 centimeters; unable to travel to the data collection location.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-6mjqrf	Evaluation of chloroquine blood levels.	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3879	A comparative bioavailability study of two formulations of chloroquine in healthy volunteers	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2017-05-08	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6mjqrf	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"hypersensitivity to the drug (clhoroquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-27qyp2	A study of three formulations of primaquine in healthy volunteers	Recruitment completed	Intervention	2020-05-27	<NULL>	<NULL>	3880	A comparative bioavailability study of three formulations of primaquine in healthy volunteers	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-05-15	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-27qyp2	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"Hypersensibility to the drug (primaquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-563rmd	Effect of therapeutic laser on lip performance	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3881	Effect of low-level laser therapy on the performance of the orbicularis oris muscle	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-563rmd	<NULL>	Age between 18 and 35 years; sign the Informed Consent Form	use of myorelaxing and/or anti-inflammatory drugs; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-6xfzht	Nutritional Assistance Study in Overweight Elderly submitted to Bodybuilding Training	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3882	Randomized Nutritional Intervention Study in Overweight Elderly submitted to Strength Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6xfzht	<NULL>	Volunteers of both genders; age greater than or equal to 60 years; overweight (Body Mass Index greater than or equal to 25kg / m²) classified according to the world health organization or waist circumference (WC) classified as high risk for women (WC greater than or equal to 80cm) and men (WC greater than or equal to 94cm ); absence of mental or psychological illnesses; without physical limitations.	Age less than 60 years; absence of excess weight (Body Mass Index less than or equal to 25kg / m²) classified according to the world health organization or waist circumference without the presence of high risk for women (WC greater than or equal to 80cm) and men (WC greater than or equal to 94cm); mental or psychological illnesses; people with physical limitations; refusal to the informed consent term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-52ynpq	Evaluation of the vibration transmission and activation of the muscles of the arm of the elderly during the exercise of whole-body vibration	Recruiting	Intervention	2020-05-27	<NULL>	<NULL>	3883	Evaluation of transmissibility and muscular activation in upper limbs of the elderly during the exercise of whole-body vibration	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-52ynpq	<NULL>	Age equal or superior to 60 years; body mass index between 22 and 27; women should be in the postmenopausal period; not presenting acute or chronic unstable diseases; not have participated in physical training in the last three months; (metal implants, cardiac pacemaker, benign or malignant tumors, epilepsy, arrhythmias, aneurysms, gallstones / renal and recent deep venous thrombosis or phlebitis); not present a history of upper and lower limb injuries that prevent him from performing the exercise on the platform; sign the informed consent form.	Don&apos;t complete the protocol, exacerbation diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2bpfjs	Impact of Curcumin Application on Lichen Planus Oral lesions	Recruitment completed	Intervention	2020-05-28	<NULL>	<NULL>	3884	Impact of Topical Application of nanoparticulate Curcumin in the treatment of Oral Lichen Planus lesions	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-06-02	Faculdade de Odontologia de Araraquara - UNESP	Coordenação de Aperfeiçoamento Pesoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2bpfjs	<NULL>	Clinical and histopathological diagnosis of OLP, based on World Health Organization criteria modified by van Der Meij et al.. These criteria take into account the association between clinical criteria (presence of bilateral lesions, more or less symmetrical; appearance of grayish and white line-shaped plaques with reticular characteristic; erosive, atrophic, bullous and plaque lesions associated with reticular lesions in any location of the oral mucosa); and histopathological criteria (presence of a well-defined zone of cellular infiltrate in the form of a band, with increased number of intra-epithelial lymphocytes as well as signs of degeneration in the basal cell layer and absence of epithelial dysplasia; keratinocyte apoptosis in the intra-epithelial region. Associated with the clinical-histopathological diagnosis of OLP, patients should be over 18 years old and have painful symptoms.	Use of medications that can induce lichenoid reactions (antihypertensive drugs, anticonvulsants, non-steroidal anti-inflammatory drugs, antibiotics and diuretics); histological signs of dysplasia; pregnant or lactating patients; presence of orthodontic appliances; lesions close to amalgam restorations and medical contraindication to the use of fluconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-9d8z6m	Safety and Efficacy of Hydroxychloroquine Associated With Azythromycin in SARS-Cov-2 Virus	Recruitment completed	Intervention	2020-03-27	<NULL>	<NULL>	3885	Open and controlled trial of hydroxychloroquine and azytromicyn use to prevent complications in patients infected by new coronavirus (COVID-19): a randomized controlled trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-03-30	Hospital do Coração	EMS	https://ensaiosclinicos.gov.br/rg/RBR-9d8z6m	<NULL>	Patients admitted to the ICU or Hospital with suspected or confirmed COVID-19	"Presence of any of the following: Need to supplement oxygen more than 4L; Use of high flow nasal catheter; Use of non-invasive ventilation; Use of mechanical ventilation; Use of hidroxichoroquine, chloroquine,
azithromycin or other macrolide over 24 hours; History of severe ventricular or QTC equal or grater than 48 ms cardiac arrithmia; History of hepatic desease (cirrosis); Renal dysfunction (estimated glomerular filtration  rate [eGFR] less than 30ml/min/1.73m2, using MDRD or CKD-EPI method); Patients with retinopathy or macular degeneration; Children under 18 years;Pregnancy; Allergy to chloroquine and derivatives; Allergy to azythromicyn; Patients in hospital over 48hr; Patients with symptoms over 14 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-22rb9m	Risk factors related to nonuse to the new lower complete denture	Not yet recruiting	Intervention	2020-05-28	<NULL>	<NULL>	3886	Risk factors related to difficulty in adaptation to new mandibular complete denture	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-30	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-22rb9m	<NULL>	Bimaxillary edentulous, need for new conventional complete dentures, absence of intraoral lesions, absence of changes in the perioral musculature.	Debilitating health that makes rehabilitative treatment unfeasible, unsatisfactory cognitive and systemic ability that compromises the analysis of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7xx7g7	Evaluation of the effect of therapies to support facial disorders on physical, psychological, social and sleep-related aspects	Data analysis completed	Intervention	2020-03-30	<NULL>	<NULL>	3887	Evaluation of the effect of support therapies for Temporomandibular Disorders (TMD) about physical, psychosocial and related to sleep	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2018-12-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7xx7g7	<NULL>	Patients with a positive diagnosis for TMD obtained through axis I of the RDC / TMD were included; those who underwent last treatment for TMD with a minimum interval of 3 (three) months; individuals with reports of pain in the orofacial region in the last 3 (three) months; patients aged 18 to 65 years.	Individuals with impaired cognitive ability who were unable to understand the questions in the questionnaires were excluded; those with a history of head trauma that is related to the etiology of orofacial pain and that can confuse the diagnosis of TMD; those with headaches or intracranial disorders; individuals who have used medications in the past 3 months that interfere with sleep quality such as muscle relaxants, anticonvulsants, antidepressants and anxiolytics; patients using medication to treat TMD or muscle pain; those who had other causes of orofacial pain such as caries, periodontal diseases, neuropathies and fibromyalgia; who had an insurmountable fear of a needle or bleeding disorders (only for the craniopuncture group).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-4wt3h7	Comparative evaluation of two motivational methods performed during Periodontal Treatment in patients with Gingival Disease	Data analysis completed	Intervention	2020-05-28	<NULL>	<NULL>	3888	"Comparative evaluation of two motivation programs carried out during Therapy
Basic Periodontal disease in patients with Gingival and Periodontal Disease"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Centro de Estudos Superiores de Maceió	Centro de Estudos Superiores de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-4wt3h7	<NULL>	"Systemically healthy patients; patients over 18 years of age and under 65
years; patients able to read and sign the IC; patients diagnosed with periodontal disease and in need of basic periodontal therapy; patients who have access to an instant messaging application (WhatsApp)."	"Patients with any pathology
that negatively influences tissue healing (eg diabetes melitus); patients using any drugs that negatively influence the oral environment; pregnant and nursing patients; patients with chronic renal failure; patients with advanced liver disease (eg, cirrhosis); patients with decompensated hypertension or an increased risk of cardiovascular disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7kjzrk	Clinical Evaluation and Temperature Variation between Gum Removal with Scalpel and Laser	Recruitment completed	Intervention	2020-05-29	<NULL>	<NULL>	3889	Clinical and Thermographic Evaluation of Conventional and High-Power Laser Gingivectomy - Split Mouth Controlled Clinical Trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7kjzrk	<NULL>	Patients with gummy smile. Clinically healthy periodontum. Absence of systemic diseases. Age between 18 and 49 years.	Smokers. Presence of orthodontic appliance. Use of medications that interfere with bleeding, pain perception and promote gingival enlargement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-8tkmr7	Fluoride soluble in artificial gastric juice as an indicator of systemic bioavailability of toothpastes	Data analysis completed	Intervention	2020-06-01	<NULL>	<NULL>	3890	Fluoride soluble in HCl 0.01 N found in  MFP/CaCO3 - based toothpaste as indicator of fluoride systemically bioavailable	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-8tkmr7	<NULL>	participants in good general health; participants with normal salivary flow (unstimulated saliva equal to or greater than 0.3 to 0.4 mL per min)	participants with kidney disease; participants with gastrointestinal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-7jdjcf	Photobiomodulation in burn patients	Not yet recruiting	Intervention	2020-06-01	<NULL>	<NULL>	3891	Use of phototherapy on autograft viability in burned participants	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2020-08-10	Universidade Federal do Ceará	Instituto Doutor José Frota(IJF)	https://ensaiosclinicos.gov.br/rg/RBR-7jdjcf	<NULL>	Adults between 18 and 59 years old, male and female; participants accompanied at the IJF at the Burn Center, who have deep second and third degree burns; individuals with indication of graft.	"diabetic people; people with signs and symptoms indicative of an infectious process; individuals with signs of hypoproteinemia or anemia; grades II and III obese individuals; people using corticosteroids (interference with healing); people
with cognitive changes (mini mental below 24 points)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-2f57cs	Intervention to prevent factors that can lead to the development of Eating Disorders and to increase positive body image factors, such as self-esteem, acceptance and respect for the body and a more intuitive diet	Recruiting	Intervention	2020-06-01	<NULL>	<NULL>	3892	Preventive intervention in reducing risk factors for the development of Eating Disorders and their effectiveness in increasing Intuitive Eating, Body Appreciation and Self-esteem in young adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-26	Universidade Federal de Juiz de Fora - Campus Governador Valadares	Universidade Federal de Juiz de Fora - Campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-2f57cs	<NULL>	Female students; aged between 18 and 30 years old, of any color race or ethnicity; regularly registered at the Federal University of Juiz de Fora, campus Governador Valadares.	Students with mental disorders; with eating disorders; body satisfaction with a score lower than 5, on a 10-point scale; not participating in all meetings; absent in individual sessions, scheduled to briefly pass on the content to the absent ones in a maximum of two meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-4xktdc	Effect of Ondansetron on thermal pain levels (heat and cold), mechanical and pain control mechanisms in humans	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3893	Effect of Ondansetron on the threshold of thermal and mechanical pain and conditioned modulation of pain in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4xktdc	<NULL>	Healthy individuals of both sexes, aged between 18 and 60 years, with classification of physical status by the American Society of Anesthesiologists - ASA I, were invited to participate in the project.	Individuals with chronic pain, defined as pain lasting more than 3 months, of any origin were not included. as well as those who used analgesics, antidepressants, benzodiazepines or any drug with psychoactive action in the last 14 days prior to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-73jdz5	Botox study and facial Anesthetic Infiltration on the Tinnitus Intensity in Patients with Temporomandibular Disorders	Recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3894	Clinical trial of botulinum toxin and facial anesthetic infiltration in tinnitus intensity in patients with temporomandibular disorder	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Hospital Universitário Professor Edgard Santos/UFBA	Hospital Universitário Professor Edgard Santos/UFBA	https://ensaiosclinicos.gov.br/rg/RBR-73jdz5	<NULL>	Temporomandibular joint disorder diagnosis; otoneurologic symptoms for at least three months; at least 15 years of age; both genders; no current treatment for temporomandibular disorder or otoneurologic disease.	Allergy to lidocaine or botulinum toxin; anyone who changed therapies during the study to avoid false-positive; imunossupressed patients; diabetes mellitus; cognitive impairment; pregnancy or breast feeding; psychiatric disorders; skin conditions; clotting disturbances; neuromuscular diseases; using clacium channel blokers; antibiotics (aminoglycosides); cyclosporin; chloroquines; hydroxichloroquine; D-penicillamine; or anu=y other substance that interferes with neuromuscular transmission; Myasthenia gravis; Eaton Lambert syndrome; Amyotrophic sclerosis; or any disturbances that promote periferal neuromuscular dysfunction;  oral anticoagulante; derivates from acetylsalicylic acid; derivates from vitemin E ou Ginko Biloba	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-7p58r6	Effects of laser therapy on orofacial muscles	Not yet recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3895	Effects of photobiomodulation on orofacial muscles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7p58r6	<NULL>	Age between 18 and 60 years; sign the Informed Consent Form	craniofacial anomaly; use of myorelaxing and/or anti-inflammatory drugs; signs and/or symptoms of temporomandibular disorder; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-2dxyx4	Mechanical ventilator for use in patients with respiratory failure due to Covid-19 (VExCO)	Not yet recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3896	Mechanical ventilator for use in patients with respiratory failure due to Covid-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-04	Hospital Universitário Clementino Fraga Filho	Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia	https://ensaiosclinicos.gov.br/rg/RBR-2dxyx4	<NULL>	Adults between 18 and 70 years of age who are submitted to mechanical ventilation in a regular ventilator in controlled or assisted-controlled mode, sedated or curarized or anesthetized, clinically stable, with arterial oxygen saturation continuously monitored	"Patients under the age of 18 or over 70;
ventilated patients who are not on assisted-controlled ventilation or controlled ventilation in PCV mode (pressure-controlled ventilation); patients whose arterial oxygen saturation (SaO2) is less than 95%; patients whose ventilatory adjustments are above the following limits: positive end-expiratory pressure (PEEP) of 15 cmH2O; respiratory rate (RR) of 25 cycles per minute; driving pressure (dP = plateau pressure (Plateau) minus PEEP) of 15 cmH2O; inspiratory oxygen fraction (FiO2) of 60%;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-3cbs3w	Randomized, pragmatic, double-blind, placebo-controlled clinical study, evaluation of Hydroxychloroquine  for prevention of hospitalizations and respiratory complications in outpatients with confirmed or probable diagnosis of COVID-19	Recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3897	Randomized, pragmatic, double-blind, placebo-controlled clinical study, evaluation of Hydroxychloroquine  for prevention of hospitalizations and respiratory complications in outpatients with confirmed or probable diagnosis of COVID-19	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-05-13	EMS Farmacêutica	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3cbs3w	<NULL>	"Adults  age greater than or equal to 18 years ;patients assisted in the ER with probable or confirmed infection by COVID-19; time between symptoms and inclusion less than or equal to 7 days; present mild symptoms, with no indication of hospitalization; present at least 1 risk factor for complication (age more than 65 years; hypertension; diabetes mellitus; bronchial asthma; COPD or other chronic lung diseases; smoking
; immunosuppression; obesity"	Patients under 18 years old, hospitalization in the first care; positive test for influenza in the first visit; known hypersensitivity hydroxychloroquine / chloroquine; previous diagnosis of retinopathy or macular degeneration; previous diagnosis of QT-long syndrome; history of sudden death in close family members (parents and siblings), use of anti-arrhythmic drugs or others that may increase the bioavailability of hydroxychloroquine or enhance its effect, decompensated heart failure, symptomatic coronary artery disease; evidence of known liver disease, reported by the patient; evidence of known chronic kidney disease, reported by the patient, patients with pancreatitis, baseline ECG with QT interval greater than or equal to 480ms; chronic use of hydroxychloroquine / chloroquine for other reasons; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-63c3gn	Histomorphometric and immunohistochemical evaluation of beta-tricalcium phosphate of different particles dimensions in maxillary sinus floor elevation: a randomized clinical study	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3898	Prospective, randomized clinical study for bone repair after grafting on human maxillary sinuses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-63c3gn	<NULL>	Atrophic posterior maxillary region and residual bone height less than 5 mm requiring bone augmentation rehabilition with dental implants.	smokers, patients with uncontrolled systematic disease, maxillary sinus diseases, and patients with an inadequate amount of bone in the mandible symphysis where the autogenous bone graft was harvested.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-4pjmbb	Therapeutic Ultrasound associated with the application of copaiba and tea tree oil in the treatment of leg ulcers: a controlled and randomized clinical study	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3899	Low Frequency Ultrasound associated to application of Copaíba and Melaleuca Oil in process of healing of Venous Ulcers: Controlled and Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pjmbb	<NULL>	"Individuals over 18 years of age;
To present venous ulcer;
To attend the outpatient clinic on pre-established days, for at least 10 days after the start of the intervention;
To present glycemic control, without the use of anti-inflammatory medication by any route of absorption."	"Present necrotic tissue with indication of limb amputation;
Under treatment by radiotherapy;
Wounds due to radiotherapy; Pregnant patients;
Patients with metallic implants in the region; Diagnosis of deep venous thrombosis; Hemophiliac patients or those at risk of hemorrhage;
Smoking patients; Patients on corticosteroids; Diabetic patients;
Use unna&apos;s boot as a treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-99kc3d	To wear wrist orthosis can cause compensation on shoulder movement	Recruiting	Observational	2020-06-03	<NULL>	<NULL>	3900	Influence of wrist constraint on shoulder muscle coordination and upper extremity kinematic during reaching-to-grasp tasks	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-19	Sao Paulo Research Foundation	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-99kc3d	<NULL>	Individuals 18-85 years old; pain-free full range of motion of shoulder, elbow and wrist	Women who are pregnant; Systemic neurological disease or injury (Parkinson’s disease, Multiple sclerosis, Stroke, etc.); Systemic inflammatory disease or arthropathy (i.e. Rheumatoid arthritis); Hemophilia or other forms of bleeding disorders, or use of anti-coagulation medications (if fine-wire EMG will be used); Consistent use of narcotic pain medication or anti-inflammatory medication; Upper extremity weight-bearing used for mobility; Previous fracture to the upper extremity being tested; Previous surgery to the upper extremity being tested; Seeking care from a healthcare provider for the upper extremity to be tested (i.e. pain, arthritis, etc.) either currently or within the last 6 months; Previous or current imaging showing a full thickness rotator cuff tear in the arm to be tested; Shoulder pain with cervical spine motion; Previous or current substantial pain in the upper extremity to be tested	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-588cfq	Improvement of quality of life after knee prosthesis	Recruitment completed	Intervention	2020-06-03	<NULL>	<NULL>	3901	Evaluation of quality of life improvement after total knee artrhroplaty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Marco Antonio Percope de Andrade	Marco Antonio Percope de Andrade	https://ensaiosclinicos.gov.br/rg/RBR-588cfq	<NULL>	Unilateral symptomatic primary or secondary OA of the knee;  age of 45 years or older; indication of a primary total knee replacement; signed the informed consent form	Bilateral symptomatic osteoarthritis; not accept to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-7j49sm	Guided implant surgeries x Freehanded surgeries	Recruitment completed	Intervention	2020-06-03	<NULL>	<NULL>	3902	Implant surgeries using 3D prototyped guide x Freehanded surgery: controlled and randomized split-mouth clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-03-01	FAESA Centro Universitário	FAESA Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-7j49sm	<NULL>	Good oral hygiene with visible plaque index less than or equal to 20%; age greather than or equal to 18 years; sufficient bone availability for implant installation, with minimum height and thickness equal to 10 and 5mm, respectively; loss on both sides of the mandible of posterior teeth; sufficient interocclusal height to adapt the prototyped surgical guide and perform the perforations.	History of periodontal surgical procedures in the operated region; systemic alterations that could compromise the surgical procedures or healing; presence of inflammation or infection involving the region to be operated; bone pathology in the implant site; smokers, people with bruxism, alcoholics, drug addicts, diabetics, pregnant women or those who wish to become pregnant in the next year, who have a history of radiotherapy treatment in the head and neck region, who take medications that may interfere with bone remodeling or that have pathologies that affects bone metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-8hcyfq	Mindfulness Training for Stress reduction in workers at a university in the interior of São Paulo	Recruitment completed	Intervention	2020-06-03	<NULL>	<NULL>	3903	Mindfulness Based Protocol for Stress Reduction among Workers in a Brazilian University: Randomized Clinical Trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-07-01	Escola de Enfermagem de Ribeirão Preto	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8hcyfq	<NULL>	First phase of the study: being a technical-administrative employee at USP&apos;s Ribeirão Preto campus; both sexes; be 18 years of age or older. Second phase of the study (intervention): Score at or above 23 points on the PSS14 scale.	First phase of the study: less than one year of employment at the institution; be an outsourced employee; not responding to the USP campus in Ribeirão Preto; be on leave for health reasons or maternity leave. Second phase of the study (intervention): practice some type of meditation in the last 12 months; being under treatment with psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-3k6982	Evaluation of irritability and sensitization of health products, through the contact test.	Not yet recruiting	Observational	2020-06-03	<NULL>	<NULL>	3904	"Assessment of primary skin irritability,
accumulation and awareness of products for
through the contact test."	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Makelab Consultoria Eireli	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-3k6982	<NULL>	Women; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the region; Occasional user of products of the category	"Participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions; Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Volunteers with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; History of pathologies aggravated or triggered by ultraviolet radiation; Immunodeficiency sufferers; Kidney, heart or liver transplantation; Forecast of intense sun exposure or tanning session during the period
conducting the study; Forecast of bathing in the sea, pool or sauna during the study; Participants who practice water sports; Use of the following medications for systemic topical use: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and / or its derivatives orally or topically up to 01 month before the beginning of the study; Vaccination forecast during the study or up to 03 weeks before the study; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-39srtp	Effects of vitamin D3 supplementation on oxidative and inflammatory stress markers in overweight or obese workers	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3905	Effects of vitamin D3 supplementation on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-39srtp	<NULL>	women aged between 18 and 59 years; have vitamin D deficiency or insufficiency; have a Body Mass index greater than 25 kg / m²; do not take any vitamin D supplementation; not taking anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; not having a diagnosis of Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; do not drink alcoholic beverages; do not smoke	Women with previous vitamin D use; women under 18 or over 59; women using anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; women diagnosed with Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; Alcoholic women; smoking women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-76c257	Effects of different physical activity programs on women&apos;s health	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3906	Effects of Long-Term Physical Activity Programs on Physical Capacity, Body Composition and Symptoms of Anxiety and Depression in Women	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-76c257	<NULL>	Being female; age between 18 years and 80 years; body mass index (BMI) greater than or equal to 25 kg / M2; use the public health service.	against medical indications to perform physical activity with moderate and vigorous intensity; have a cardiac pacemaker; pregnant women; already carry out physical activity programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-43hbks	Evaluation with ultrasound on the bedside in serious patients with COVID-19	Recruiting	Observational	2020-06-03	<NULL>	<NULL>	3907	Evaluation with point-of-care ultrasound in serious patients with COVID-19	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-04-21	Disciplina de Cirurgia Vascular e Endovascular da Universidade Federal de São Paulo	Disciplina de Cirurgia Vascular e Endovascular da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43hbks	<NULL>	patients admitted to the intensive care unit with a confirmed Covid-19 diagnosis	covid-19 suspect patient (not yet confirmed)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-82chym	Effects of physical exercise under different levels of effort to prevent atherosclerosis and risk factors in elderly women	Recruitment completed	Intervention	2020-06-03	<NULL>	<NULL>	3908	Effects of high intensity combined training on subclinical atherosclerosis and cardiometabolic factors in elderly women	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2018-08-08	Universidade Federal de Goiás	Instituto Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-82chym	<NULL>	60 years old and 79 years old; signature of the TCLE (according to resolution 466/2012); possibility of regular attendance; sedentary; not be diabetic; without limitations and / or motor disability of any kind.	Body mass index between 24 Kg / m2 and 40 Kg / m2; abdominal circumference greater than 80 cm; estimate of the metabolic equivalent (MET) below 4.5 METS or above 7.5 METS (&lt;15.75 or&gt; 26.25 ml / kg / min of Maximum Oxygen Volume).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-772s6y	Study of efficiency and effectiveness of a new family of introcular lenses	Not yet recruiting	Intervention	2020-06-04	<NULL>	<NULL>	3909	Study of the effectiveness and efficiency of a new family of single-focal and multifocal introcular lenses under the Customized Cataract Solution project	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-06-01	João Marcelo de Almeida Gusmão Lyra	MediPhacos Industrias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-772s6y	<NULL>	Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular or a combination) that was considered amenable to treatment by extraction of the cataract using the intracapsular facectomy method. Adult patients 21 years of age or older. Patients eligible for primary intraocular lens implantation. Patients willing and able to perform clinical and complementary exams for follow-up for a minimum of 1 year after cataract surgery. Patients requiring intraocular lens implantation powers ranging from 10 to 30 diopters. Patients with visual potential of 20/40 or better in the eye indicated for intraocular lens implantation. Patients with corneal cylinder to correct less than 1 diopter.	"Patients with the best corrected visual acuity less than or equal to 20/200 in the contralateral eye.
Patients with any pathology of the anterior segment in which the intracapsular facectomy procedure with primary IOL implantation is contraindicated (examples: keratoconus, corneal dystrophies or scars, anterior uveitis).
Patients with corneal inflammation or edema, included and not limited to: keratitis, keratoconjunctivitis and keratitis.
Patients with uncontrolled glaucoma or glaucoma under treatment.
Patients with a history of retinal detachment.
Patients with diabetic retinopathy (proliferative or non-proliferative).
Patients with congenital, metabolic, traumatic or complicated cataracts.
Patients with marked microphthalmia or aniridia.
Patients who have had previous proposed eye surgery.
Patients who have already received another IOL in the contralateral eye.
Irregular astigmatism of the cornea.
Amblyopia.
Clinically significant changes in the retinal pigment epithelium / macula.
Neovascularization of the iris, camerular and retinal angles.
Severe recurrent inflammation of the anterior or posterior segment of unknown etiology.
Optic atrophy.
Patients with immunodeficiency (infectious, neoplasic or medicated)
Patients on chronic use of systemic steroids or immunosuppressive drugs.
Patients participating in another clinical trial simultaneously.
Patients with strong dependence on intermediate vision, night vision or specific occupational requirements (examples: commercial pilots and professional drivers)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-949z6v	Full versus prophylactic anticoagulation for the treatment of severe forms of Covid-19:	Recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3910	Full versus prophylactic heparinization for the treatment of severe forms of SARS-Covid-19: clinical, randomized, open and controlled study - HeSAcovid trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-30	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-949z6v	<NULL>	Age above or equal to 18 years; SARS-covid-19 infection confirmed through RT-PCR; Severe forms confirmed by the presence of ARDS according to the Berlin classification ( bilateral infiltrate on chest X-ray, arterial hypoxemia with a PaO2 / FIO2 ratio &lt;300, absence of structural heart disease or evidence of insufficiency acute cardiac arrest; Presence of severe clinical presentation with respiratory failure requiring orotracheal intubation or mechanical ventilation or maintenance of RF&gt; 24 ipm and saturation &lt;90% after the administration of supplemental oxygen through a nasal catheter at 4 liters / min; Dosage of D-dimer greater than and equal to 0.5 pg / ml; Presence of prothrombin time (TP / INR) &lt;1.5 and APTT (activated partial thromboplastin time (APTT) &lt;1.5; Platelet count greater than 100,000 / mm3	Age over 85 years; creatinine clearance &lt;10 ml / min; severe circulatory shock with a dose of norepinephrine greater than 1.0 pg / Kg / min; Chronic renal patients on hemodialysis; chronic Child B and C liver disease; advanced diseases (active neoplasia, heart failure functional class III and IV, COPD in chronic use of oxygen with more than 2 exacerbations in the last year, advanced dementia, bedridden patient with significant sequelae of stroke or traumatic brain injury; cardiorespiratory arrest; pregnant women; recent major surgery in the last 3 weeks; recent stroke in the last 3 months; presence of active bleeding; presence of blood dyscrasia such as: hemophilia, Von Willebrand factor deficiency, etc.; participation in another clinical investigation with associated intervention; formal indication for oral anticoagulation for other reasons such as: pulmonary embolism, acute coronary syndrome, etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-9kvw9t	Evaluation of efficacy and efficiency of a removable esthetic appliance for solving teeth crowding in the childhood: a randomized clinical trial	Recruitment completed	Intervention	2020-06-04	<NULL>	<NULL>	3911	Evaluation of efficacy and efficiency of clear aligners for solving incisor crowding in the mixed dentition: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-21	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Faculdade de Odontologia de Bauru/FOB/USP	https://ensaiosclinicos.gov.br/rg/RBR-9kvw9t	<NULL>	7 to 11 years old, mixed dentition phase, with definitive primary crowding of at least 3mm	Presence of agenesis of one or more upper incisors, need for the use of extraoral or extraction mechanics, presence of caries lesions, history of orthodontic treatment, cleft lip and palate, syndromes or any type of systemic or neurological alteration that makes it impossible to perform interventions and presence of white spot lesion or caries already established.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-88jff9	Evaluation of the prediction of soft tissues of the face with computed tomography of dental and bone deformities before and after surgery of retracted jaws	Data analysis completed	Intervention	2020-06-04	<NULL>	<NULL>	3912	Uncontrolled experimental study: pre and postoperative tissue evaluation, using computed tomography, of a series of cases with class II Dentoeskeletal deformity, surgically treated	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Instituto de Gestão Estratégica de Saúde do Distrito Federal	Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-88jff9	<NULL>	The present study included 16 clinically healthy patients, all classified as Angle class II, in whom control CT scans had been obtained at an interval of 6 to 72 months after surgery. All cases had undergone prior orthodontic preparation with a view to orthognathic surgery	Patients with syndromic dentofacial deformities; asymmetries;  postoperative follow-up of less than 6 months were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-37gw2x	Effect of two therapeutic modalities on chronic hip pain	Recruiting	Intervention	2019-09-30	<NULL>	<NULL>	3913	Randomized clinical trial: Effect of a physiotherapeutic protocol in greater trochanteric pain syndrome in women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Paulista, Faculdade de Filosofia e Ciências	Universidade Estadual Paulista, Instituto de Biociências	https://ensaiosclinicos.gov.br/rg/RBR-37gw2x	<NULL>	Being female. Volunteers must be between 25 and 70 years old. Present pain and chronic lateral tenderness in the hip greater than or equal to 3 months. Pain in at least 1 of the 7 provocative pain tests which is intended to transmit compressive or tension forces in the hip abductor muscles tendons. Do not engage in regular physical activity and present comparable demographic data between groups.	Present body mass index greater than 36kg / m2. Have received some type of invasive intervention to reduce pain in the evaluated region in the last year. Physical therapy intervention in the last 3 months. Present limitation in the range of motion of the spine and hip or lower limbs that disables gait. Present limitation in the range of motion that disables tests or training. Any disease that affects the neuromuscular system or that may prevent data collection. Spinal or hip surgery. Any infectious or neoplasic condition. Can not compromise with the weeks of training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-876qb5	Treatment of severe cases of Covid-19 with Eculizumab	Recruiting	Intervention	2020-06-08	<NULL>	<NULL>	3914	Eculizumab for the treatment of Covid-19 severe cases	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-27	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-876qb5	<NULL>	COVID-19 diagnosis confirmed by RT-PCR. Age between 18 and 80 years. Severe form of SARS-CoV-2 infection. ECOG prior to infection &lt; ou igual a 2.	Age less than 18 years or more than 80 years. Known hypersensitivity and / or previous eculizumab therapy; septic shock and / or multiple organ failure syndrome; hstory of infection by human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C (HCV) (with the exception of chronic infections treated or cured for HBV and HCV, which will be accepted); neoplasms in activity or under treatment, except for basal cell carcinomas; any major surgery, extensive radiation therapy, delayed toxicity chemotherapy, biological therapy, or immunotherapy within 6 weeks prior to clinical trial screening; any investigational medication other than the study drugs in the 6 weeks before the first dose of the study drug; history of chronic liver disease (Child-Pugh B or C); hystory of chronic kidney disease (glomerular filtration rate &lt;30 mL / min / 1.73 m²); any contraindication to the use of penicillin for bacterial meningitis&apos;s prophylaxis during the use of eculizumab; any contraindications to the use of contraceptive methods in childbearing age women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4qjzh7	Study of vascular complications in critically ill patients with coronavirus	Recruitment completed	Observational	2020-06-08	<NULL>	<NULL>	3915	A prospective observational study of vascular complications in critically ill patients with covid-19	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-04-17	Disciplina de Cirurgia Vascular e Endovascular da Universidade Federal de São Paulo	Disciplina de Cirurgia Vascular e Endovascular da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qjzh7	<NULL>	patients admitted to the intensive care unit with a confirmed Covid-19 diagnosis	outpatients; patient in the ward; without  COVID-19 confirmation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2vfqnz	Clinical study to evaluate the effect of sublingual gel melatonin in healthy research participants	Not yet recruiting	Intervention	2020-06-08	<NULL>	<NULL>	3916	Monocentric phase I clinical study to assess the tolerability, safety and pharmacokinetics of sublingual melatonin gel in healthy research participants (PPES 003/19)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-2vfqnz	<NULL>	Participant of both sexes, aged 55 or over. Survey participant with laboratory results, type 1 urine examination, clinical evaluation, vital signs, and ECG within normal range and / or any deviation from normality classified as not clinically significant.	Complementary test results are 3 times higher than normal values unless clinically irrelevant. Women who are breastfeeding. Participant with a history of hypersensitivity to the study drug or chemically related compounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4w39gz	Use of Tranexamic Acid in Weight-loss surgery (Sleeve) x bleeding outcome	Recruitment completed	Intervention	2020-06-09	<NULL>	<NULL>	3917	Use of Tranexamic Acid in Bariatric surgery (Sleeve) x bleeding outcome: a controlled study	<NULL>	4, non-randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-09-12	HOSPITAL SÃO DOMINGOS	HOSPITAL SÃO DOMINGOS	https://ensaiosclinicos.gov.br/rg/RBR-4w39gz	<NULL>	Age between 18 and 65 years; both genders; physical status ASA-I or II (American Society of Anesthesiologists); submitted to bariatric surgery (Sleeve); signed informed consent form.	History of thromboembolic disease; severe comorbidity (American Society of Anesthesiologists criteria); patients using platelet-inhibiting or anticoagulant drugs; carriers of active intravascular coagulation; acute occlusive vasculopathy; known hypersensitivity to the components of the tranexamic acid formula.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4mw25f	Effect of Transcranial Direct Current Stimulation on the physical conditioning of children and adolescents with Cerebral Palsy.	Not yet recruiting	Intervention	2020-06-10	<NULL>	<NULL>	3918	Effect of Transcranial Direct Current Stimulation on the physical fitness of children and adolescents with Cerebral Palsy: a crossover, placebo-controlled, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-4mw25f	<NULL>	The participants included in the study will be children and adolescents with a diagnosis of CP of the spastic diparesis type confirmed through clinical examination; having magnetic resonance imaging showing damage to the pyramidal system, without compromising the extrapyramidal system and cerebellum; age between seven and twelve years; GMFCS level one, two and three children; children who have sufficient strength to overcome gravity and complete the range of motion of the joint regarding the flexor and extensor muscles of the trunk, hips and knees; degree of spasticity less than three on the Modified Ashworth Scale; present degree of joint mobility of the ankle compatible with positioning in a neutral position, popliteal angle below thirty degrees and Thomas test with hip flexion below twenty degrees; consent of those responsible by signing the Informed Consent Form.	Children who are diagnosed with epilepsy or who have had seizures at least twelve months before the start of the study will be excluded; who have neurological, neuromuscular diseases or syndromes associated with brain injury; who have undergone orthopedic or neurological surgery in the twelve months prior to the intervention; who have undergone neurolytic blocks in the six months prior to the intervention; who have orthopedic deformities with surgical indication; who have brain implants or who have undergone a neurosurgical procedure; who have metallic implants in the head, neck, chest and / or upper limbs regions; who have hearing aids; children with a degree of collaboration incompatible with adequate performance in the activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-9gm9bz	Determining factors of prognosis and morbidity in Chronic Chagas Heart Disease - phase III	Recruiting	Intervention	2020-06-12	<NULL>	<NULL>	3919	Determining factors of prognosis and morbidity in Chronic Chagas Heart Disease - phase III	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9gm9bz	<NULL>	"Diagnosis of Chagas disease by at least two of the three positive serological tests for Trypanosoma cruzi (indirect immunofluorescence, indirect hemoglutination and ELISA). Present a stable clinical condition, defined as no acute exacerbation of heart disease in the last three months. Presence of cardiac involvement defined, on echocardiogram, by the presence of left ventricular dysfunction (ejection fraction lower 52% for males and 54% for females). Presence of clinical signs and symptoms of heart failure (NYHA II and III). Not being a smoker and denying routine exposure to smoking
Presence of inspiratory muscle weakness defined with maximum inspiratory pressure values lower 70% of predicted. Be aged between 30 and 60 years. Be sedentary according to the International Physical Activity Questionnaire (IPAQ). Not having previous episodes of stroke and not having pulmonary, renal pathologies, musculoskeletal limitations and diabetes mellitus, conditions that alter the ability to perform functional tests."	"Warm-up activities before carrying out stress tests as well as any other contraindications to the maximum and submaximal tests.
Failure to perform the study&apos;s evaluation procedures. Only for the experimental group: do not perform inspiratory muscle training for two days in the same week (at home) or are absent from two supervised sessions during training."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3kjjc4	Antimicrobial effects of Silver Diamine Fluoride compared to Chlorhexidine	Recruitment completed	Intervention	2018-10-16	<NULL>	<NULL>	3920	Antimicrobial effects of treatment with  Silver Diamine Fluoride compared to Chlorhexidine	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-21	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3kjjc4	<NULL>	"Patients who present at least one active carious lesion in deciduous molar located in the external half of the dentin, without pulpal or periodontal disease;
Both sexes;
Age range: 7 to 10 years."	"Children whose parents did not sign the Informed Consent Form;
Children who did not assent to participate in the study;
Children who had some type of systemic impairment and/or special needs throughout treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4j5g96	Characterization of the patient with painful click in the jaw joint.	Data analysis completed	Observational	2020-06-15	<NULL>	<NULL>	3921	Clinical, somatosensory and psychosocial characterization of patients with painful temporomandibular joint clicking: a cross-section study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	FACULDADE DE ODONTLOGIA DE BAURU	FACULDADE DE ODONTLOGIA DE BAURU	https://ensaiosclinicos.gov.br/rg/RBR-4j5g96	<NULL>	Volunteers with complaints of clicking and pain or just clicking on the temporomandibular joint; both genders; age between 18 and 70 years.	Volunteers with different clicking noises; individuals with complaints of non-articular pain; patients with a known diagnosis of degenerative joint diseases; patients who had undergone previous surgery of the temporomandibular joint; individuals under the influence of analgesic, anti-inflammatory, antidepressant, anticonvulsant and benzodiazepine medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-8q8c6n	Effect of laser on individuals with tinnitus.	Data analysis completed	Intervention	2020-06-15	<NULL>	<NULL>	3922	The use of low-level laser in patients with tinnitus and without hearing loss	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-18	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-8q8c6n	<NULL>	Consent to the Informed Consent Form. Normal bilateral audiometry with ISO mean up to 25dB. Complaint of continuous tinnitus for at least six months. Age 18 years or older.	Performing another treatment for tinnitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-86tszx	Effects of Respiratory Physiotherapy techniques on Preterm Newborns	Recruitment completed	Intervention	2020-06-15	<NULL>	<NULL>	3923	Comparison between the Thoraco-abdominal Rebalancing method and Assisted Autogenous Drainage in the care of the Premature Neonate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-86tszx	<NULL>	Preterm newborns with corrected gestational age of up to 36 weeks and 6 days; with more than 72 hours of life; without pressure ventilation support; hemodynamically stable; Silverman-Andersen Bulletin (BSA)&gt; 1; weight greater than or equal to 1,100 g and with increasing weight gain.	Preterm newborns with congenital malformations; in parenteral nutrition; score of apgar in the 5th minute &lt;6; with grade III or IV Peri-intraventricular hemorrhage (PIVH).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-6wq24d	Effects of the application of Therapeutic Ultrasound associated with Eletrical Stimulation  in Pain and Funcionality in women cesarian section	Recruitment completed	Intervention	2020-06-15	<NULL>	<NULL>	3924	Combined Therapy (Ultrasound and Transcutaneous Eletrical Nerve Stimulation) improves Pain and Functional Limitation in post cesarean: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-23	Universidade Federal Do Paraná	Maternidade Victor Ferreira do Amaral do Complexo do Hospital de Clínicas	https://ensaiosclinicos.gov.br/rg/RBR-6wq24d	<NULL>	Women over 15 years of age;underwent cesarean during labor for at least 8 hours and a maximum of 24 hours after the procedure; post-cesarean pain	illiterate or non-oriented; presence of puerperal intercurrences such as: local bleeding requiring intervention, signs suggestive of infection, fever, anesthetic complications and breast intercurrences; diagnosis of epilepsy, demyelinating disease, spindle trauma, tumors, diabetes mellitus and hypertension; puerperal women who use pacemakers or implanted electronic devices; presence of local drainage system and;  irritation or intolerance to the application of Combination Therapy (history of allergy or intolerance to the application of electrical current or therapeutic ultrasound)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2jv3sy	Positioning of the gastric tube in newborn	Not yet recruiting	Intervention	2020-06-15	<NULL>	<NULL>	3925	Randomized clinical trial on gastric tube placement in newborns using three measurement methods	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Escola de enfermagem da Universidade Federal de Minas Gerais	CNPq	https://ensaiosclinicos.gov.br/rg/RBR-2jv3sy	<NULL>	Newborns; Admission to the Neonatal Progressive Care Unit; indication of gastric catheterization; clinical stability	Children with complex malformations; gastrointestinal tract malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-5g9f6w	Rehabilitation of Children and Adolescents with Cystic Fibrosis	Recruiting	Intervention	2020-06-17	<NULL>	<NULL>	3926	Effect of Exergame on cardiorespiratory fitness of children and adolescents with Cystic  Fibrosis: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-11	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5g9f6w	<NULL>	Children and adolescents; both gender; age between 6 and 18 years with a clinical diagnostic of cystic fibrosis	Presentation pulmonary deterioration ( FEV1 less than 50%), exacerbation (hospital admission or progressive decline in lung function with episodes of acute worsening of respiratory symptoms) within the last 6 weeks of study initiation, presenting cardiovascular, neuromuscular or osteoarticular disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4n3cg2	Evaluation of quality of life with voice and difficulty swallowing in patients undergoing surgery to remove the entire larynx for cancer	Not yet recruiting	Observational	2020-06-19	<NULL>	<NULL>	3927	Voice quality of life and dysphagia in patients undergoing total laryngectomy with speech rehabilitation: prosthesis, esophageal voice, and electronic larynx: a multicenter study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Giulianno Molina de Melo	Real e Benemérita Associação Portuguesa de Beneficência/SP	https://ensaiosclinicos.gov.br/rg/RBR-4n3cg2	<NULL>	patients undergoing total laryngectomy with primary speech rehabilitation within a minimum of six months after surgery; patients undergoing total laryngectomy with secondary speech rehabilitation six months after insertion when surgery and radiotherapy; patients undergoing total laryngectomy with speech rehabilitation with esophageal voice six months after surgery and radiation therapy; patients undergoing total laryngectomy with speech rehabilitation with electronic larynx six months after insertion when surgery and radiotherapy; patients without evidence of disease; patients capable of phoning regardless of vocal quality; patients able to read, understand and answer the QOL questionnaire; patients who agreed to participate in the study by filling out a questionnaire voluntarily	patients with tumor recurrence or persistence; patients with other than total laryngectomy; lost follow-up patients; patients who refused to participate in the study; patients with death due to illness within 6m after answering the questionnaires; patients with a follow-up of fewer than 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3jv46h	Effects of beta-alanine supplementation in muscle strength and mass.	Data analysis completed	Intervention	2020-06-19	<NULL>	<NULL>	3928	Effects of beta-alanine supplementation in neuromuscular parameters of resistance-trained young men.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3jv46h	<NULL>	individuals should have a minimum experience of 6 months with the regular practice of strength training; training frequency greater than or equal to three weekly sessions.	Those who might have clinical limitations that could compromise their health and safety would be excluded. Those who practice other types of strength training would also be excluded. During the period, the volunteer who was injured, regardless of the reason, or if he was absent from more than three consecutive training sessions, would be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4g256m	Laser and Aerobic Exercise for treatment of women with knee Arthrosis	Recruiting	Intervention	2020-06-19	<NULL>	<NULL>	3929	Phototherapy and Aerobic Exercise in women with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-4g256m	<NULL>	Knee OA according to the American College of Rheumatology by radiographic examination of the joint under weight bearing; Grade 2 or 3 knee OA confirmed by the participating physician according to the Kellgren &amp; Lawrence criterion; female individuals; age between 50 and 70 years; availability to participate in the treatment plan; BMI between 18.5, normal classification, to 39.9 kg  per meter square, obesity grade II	Paticipants with cardiovascular disease, neurological or musculoskeletal disorder that prevents the participant from performing exercises, presence of neoplasms, absolute contraindication to use photobiomodulation; evidence of secondary, inflammatory or metabolic disease, participation of other treatments that may interfere with the results of this study, individuals who have malnutrition or morbid obesity; more than 3 absences throughout the treatment and,or having two consecutive absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-48z4vp	Effects of Water Therapy on risk of falls in older people	Not yet recruiting	Intervention	2019-07-03	<NULL>	<NULL>	3930	Effects of Aquatic Physical Exercise on falls and risk factors in community-dwelling older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-19	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-48z4vp	<NULL>	Ability to walk alone; reported initial availability of attending the training twice a week; not being engaged for five or more times per week in one or more of the activities walking, running, cycling, swimming, aerobic exercise, dancing, gardening or weight lifting.	Any cardiovascular or infectious disease present in the list of the absolute contraindications described in the Physical Activity Readiness Medical Examination; score in the Mental State Mini-exam below the cut-off point designated by level of schooling minus one standard deviation; to present a motor sequelae of stroke and neurological diseases that interfere with cognition or mobility; urinary incontinence; open wounds; sensitivity to chemicals used in swimming pool; severe and uncorrected audiovisual disturbance that makes communication difficult during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-6xq95s	The Effectiveness of Associated Non-Pharmacological Measures in the prevention and redution the duration of Delirium subtypes in ICU patients	Data analysis completed	Intervention	2018-10-03	<NULL>	<NULL>	3931	The Effectiveness of Combined Non-Pharmacological Interventions in the prevention and redution the duration of Delirium subtypes in critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-14	Universidade do Estado da Bahia	Hospital Santa Izabel	https://ensaiosclinicos.gov.br/rg/RBR-6xq95s	<NULL>	Participants will be those over 18 years of age, with an expected length of stay in these units over 48 hours, who score in the E-PRE-DELIRIC score greater than or equal to 10% and who voluntarily agree to participate in the study	Patients who: are admitted to delirium; admitted to these ICUs, but who had had delirium in the previous hospitalization; are admitted in contact and / or respiratory precaution; receptive aphasia; Have severe hearing and / or visual disturbances that prevent adequate communication; To present psychiatric disorders, in acute phase, that cause cognitive alterations, like attention deficit and / or hallucinations; They are unable to understand Portuguese; Present scores on the Richmond Agitation-Sedation Scale (RASS) less than or equal to -3	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-7nqsm5	Visual Characteristics of Cholesterol Plaques in Patients with Myocardial Infarction: Contemporary Optical Coherence Tomography Findings	Data analysis completed	Observational	2020-06-22	<NULL>	<NULL>	3932	Morphology and Phenotype Characteristics of Atherosclerotic Plaque in Patients with Acute Coronary Syndrome: Contemporary Optical Coherence Tomography Findings	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-7nqsm5	<NULL>	Patients with Acute Coronary Syndrome;Optical Coherence Tomography pre-stent	Cases with poor image quality;imaging artifacts;in-stent restenosis;images from non-culprit lesions;pós-stent images.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-54dstg	Evaluation of the training of an intensive care team in the use of oxygen properly, avoiding the excess of patients who use respiratory devices.	Recruiting	Intervention	2020-06-22	<NULL>	<NULL>	3933	Evaluation of the multidisciplinary training of the intensive care team on the conservative use of oxygen and reduction of hyperoxia in patients undergoing mechanical ventilation.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Hospital Universitário da Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-54dstg	<NULL>	Patients admitted to intensive care over 18 years of age; need to use mechanical ventilation for more than 24 hours.	Patients intubated in another unit for more than 24 hours; need for FiO2 above 50% and or e and / or PEEP&gt; 8 cmH2O; patients in palliative care; peripheral vasculopathy; Raynaud&apos;s phenomenon present; ulcers in extremities; severe vasoconstriction; absence of consent from the patient or first-degree family member; patient previously admitted to the unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-98z5rj	Feasibility of Using the NIRS Technique to Record Prefrontal Cortex Brain Activity During an Affective Neurofeedback Task	Recruitment completed	Intervention	2020-06-22	<NULL>	<NULL>	3934	Feasibility of Using NIRS Technique for Mapping Cortical Hemodynamic Function and Studying the Functional Connectivity of the Human Brain	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal do ABC	Universidade Federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-98z5rj	<NULL>	healthy participants; right-handed; both genders; age between 18 and 60 years; normal or corrected vision	participants using drugs that alter the central nervous system; participants diagnosed with mental disorders; left-handers; participants who have a phobia of snakes, spiders, dark or natural disasters	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-6fgjcb	The effect of telephone calls made by nurses on the adaptation of people with intestinal ostomy	Recruitment completed	Intervention	2020-06-22	<NULL>	<NULL>	3935	Effectiveness of intervention in light of Roy&apos;s adaptation model in ostomized people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-04	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6fgjcb	<NULL>	As for the inclusion criteria, individuals aged 18 years or older, with cognitive ability to answer the questions, with intestinal ostomy during the data collection period, with surgery time bigger or equal 12 months and with telephone contact were selected.	Individuals who did not complete the instrument, people under the influence of alcohol / illicit drugs during the interview and people deprived of their liberty through the prison system were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3fryp7	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
wisdom tooth extractions"	Data analysis completed	Intervention	2020-06-22	<NULL>	<NULL>	3936	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
extractions of impacted lower third molars"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2013-11-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3fryp7	<NULL>	Age between 18 and 50 years; both sexes; no systemic disease or locoregional changes that may affect the tissue repair process or in post-operative sensitivity.	Contraindications of dexamethasone, paracetamol, codeine phosphate and mepivacaine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3qc35b	Effect of phone call made by nurses on elderly people with demencia and their caregivers	Recruitment completed	Intervention	2020-06-23	<NULL>	<NULL>	3937	Effect of telecare on elderly people with dementia and their caregiver	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-11	Universidade Federal Fluminense	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3qc35b	<NULL>	Elderly: having a dementia diagnosis; Have primary caregiver; Be accompanied by the dementia service in University Hospital in Brasilia;  Be aged 65 and over, Mini Mental State Examination - MMSE less than or equal to 26. Caregiver: caregiver is available for orientation; to have cognitive capacity of answer oriented in the time and space for this interface with the researcher and to accept to participate of the research.	Elderly: possess clinical instabilities such as oxygen balloon, decompensated Congestive Heart Failure, cancer, congestive obstructive pulmonary disease, cardiovascular diseases, cerebrovascular diseases, psychiatric diseases, and advanced palliative care. Caregivers: hearing impaired caregivers who limit communication by phone and video call; and caregiver with untreated psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4cwps2	Effects of electrostimulation in patients with chronic pain from HIV	Data analysis completed	Intervention	2020-06-23	<NULL>	<NULL>	3938	Effects of Interferential Current upon HIV neuropathic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-02	Universidade La Salle	Universidade La Salle	https://ensaiosclinicos.gov.br/rg/RBR-4cwps2	<NULL>	Women with HIV/AIDS; aged between 18 and 65 years; in antiretroviral therapy; have neuropathic cervicalgia, confirmed by LANSS scale.	Active contagious infection (meningitis, pulmonary tuberculosis); history of chronic diseases associated with neuropathic pain (diabetes, lupus, rheumatoid arthritis, infection by Human T-cell Lymphotropic Virus); chronic renal or peripheral vascular insufficiency; oncologic disease; severe disease that limits the understanding of the informed consent or tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-6xpd34	Collaborative approach in clinical simulation	Recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3939	Collaborative approach in clinical simulation: new conduction proposal	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-12	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6xpd34	<NULL>	Being an academic in the undergraduate nursing course at the Federal University of Goiás; have attended or are attending a course in child health.	Absence in the pre or post-test; failure to complete the anxiety-related inventory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-2d3sf9	Effect of laser auriculotherapy on signs and symptoms of patients with problems in the chin joint.	Not yet recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3940	Effect of low-power laser auriculotherapy on signs and symptoms of patients with muscular temporomandibular disorder. A comparative study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-30	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2d3sf9	<NULL>	"Adult volunteers aged 18 years or over;
score equal to or greater than 3 in the
Triage Questionnaire of the American
Academy of Orofacial Pain; with the
presence of myofascial pain according to
the Research Diagnostic Criteria for
Temporomandibular Disorders (RDC /
TMD)."	"Volunteers with non-painful
temporomandibular disorder according to
RDC / TMD; patients with associated
diseases: fibromyalgia, facial paralysis,
rheumatoid arthritis, mental illness or
cognitive deficits that would impede the
understanding of some of the stages of the
research; pregnant women; with external
ear injuries or with immunodepression;
carriers of clotting disorders, metabolic,
vascular or neoplastic diseases; volunteers
submitted to other types of associated
therapies - interocclusal apparatus,
psychotherapy, physiotherapy, orthodontics,
alternative therapies; volunteers who use
continuous medication (analgesics, antiinflammatories,
muscle relaxants,
antidepressants / anxiolytics,
anticonvulsants)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-3zdynp	Using Tocilizumab in critically ill patients with COVID-19.	Recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3941	Clinical Characterisation Protocol for Severe Emerging Infections ISARIC/WHO: COVID-19	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-03-16	Victor Côrtes Pourchet de Carvalho	Hospital Niterói D´Or	https://ensaiosclinicos.gov.br/rg/RBR-3zdynp	<NULL>	"COVID-19 disease with more than seven (7) days of symptoms plus two of the following criteria:

1- Fever (axillary temperature greater than or equal to 38 degrees centigrade)
2- D-dimer greater than 1000 or elevated PCR-t or IL-6.
3- Ventilatory deterioration or gas exchange or need for ventilatory support (non-invasive or mechanical ventilation)"	Primary or secondary immunodeficiency. Use of immunosuppressive drugs. Under 18 years old. Pregnancy. Symptoms of less than seven (7) days. Absence of respiratory symptoms. End-of-life care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-24shfp	Effect of transcranial stimulation after stroke	Recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3942	Effect of transcranial electrical stimulation on locomotion and balance after stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-20	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-24shfp	<NULL>	Patients with a diagnosis of stroke for at least 3 weeks and at most 1 year will be included; both genders; over 18 years; able to walk without assistance for 10 minutes without interruption.	Presence of metal in the cranial cavity; scalp lesions; use of a pacemaker; joint deformity in lower limbs or upper limbs; previous skull surgery; use of medications that interfere with cortical excitability; uncontrolled epilepsy; severe cognitive impairment; global aphasia; visual disturbances; other neurological diseases and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-992839	The use of therapeutic paracetamol ice cream in the postoperative period of children: a randomized clinical trial	Not yet recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3943	The use of an Emulsion formula of the type Therapeutic Ice Cream Of Paracetamol in the children&apos;s Post-Operatory: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Centro Universitário Luterano De Palmas - CEULP/ULBRA	Universidade Luterana Do Brasil - ULBRA	https://ensaiosclinicos.gov.br/rg/RBR-992839	<NULL>	Children aged 6 to 12 years; Conditioned children (collaborators); Children with indication of extraction on any deciduous or permanent teeth; Of both sexes (male and female); Children who have signed the free and informed consent term (TALE ); Children whose legal guardian has signed the informed consent form (ICF)	Children with sensitivity to the components of the paracetamol / ice cream formulation; Children under 6 years of age; Children with lactose intolerance.; Children with cognitive development disorders; Children with heart disease; Children with liver disease; Children with kidney disease; Children with coagulopathy; Children with diabetes; Children unaccompanied by their legal guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4msz4x	Evaluation of the degree of root coverage in exposed dental roots without interproximal bone loss, using conjunctive graft and autologous membrane in the Coronal Gum Repositioning technique.	Recruitment completed	Intervention	2020-06-24	<NULL>	<NULL>	3944	Evaluation of the degree of Root Covering of Muller class I and II recessions using Connective Graft and L-PRF in the Flap Coronal Repositioning technique.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-4msz4x	<NULL>	Volunteers in good general health (ASA I), with bilateral Muller class I or II gingival recession of at least one dental element in each quadrant of the maxilla (incisors to second premolar), with periodontal health and good plaque control.	Smoking, diabetic, pregnant or lactating volunteers with periodontal disease were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-7xskj7	Counseling as a treatment for women with Depressive Symptoms in high-risk pregnancy	Recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3945	Counseling therapeutic intervention for women with Depressive Symptoms in high-risk pregnancy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-10	Marlise de Oliveira Pimentel Lima	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xskj7	<NULL>	Be over 18 years old; be able to understand instructions and answer questions in Brazilian Portuguese; agree to participate in the research by signing the Informed Consent Form; being between 18 up to 26 weeks of gestation; having a diagnosis of any pathology that classifies pregnancy as a high-risk pregnancy.	Use of antidepressant or anxiolytic medication in the current pregnancy; being under psychiatric/psychological treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-33ytqc	Evaluation of COVID-19 in patients with Chronic Inflammatory Rheumatic Diseases.	Recruiting	Observational	2020-06-24	<NULL>	<NULL>	3946	Brazilian study of patients with Immunomediated Chronic Inflammatory Diseases infected by the new Corona virus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 - SARS-COV-2) - Reumacov Brasil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-13	Socidade Brasileira de Reumatologia	Departamento de Ciência e Tecnologia - Decit	https://ensaiosclinicos.gov.br/rg/RBR-33ytqc	<NULL>	Age greater than or equal to 18 years; Diagnosis of DRIM defined according to the American College of Rheumatology (ACR) or European League against Rheumatism (EULAR), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren&apos;s syndrome (SS), systemic sclerosis (ES), inflammatory myopathies , mixed connective tissue disease (DMTC), overlap syndrome, vasculitis, spondyloarthritis (AS), systemic sclerosis (ES); Current or past suspicion of COVID-19 infection; Understanding and signing the consent form of the patient or his legal representative. Inclusion criteria for the unexposed comparison group, age greater than or equal to 18 years; Diagnosis of DRIM defined according to the American College of Rheumatology (ACR) or European League against Rheumatism (EULAR), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren&apos;s syndrome (SS), systemic sclerosis (ES), inflammatory myopathies , mixed connective tissue disease (DMTC), overlap syndrome, vasculitis, spondyloarthritis (AS), systemic sclerosis (ES); There were no symptoms suggestive of COVID-19 during the study collection period; Understanding and signing the consent form of the patient or his legal representative.	Immunosuppressed by other causes, such as people living with HIV, CD4 + &lt;200 cells / mm3, organ transplantation, primary immunodeficiency, neoplasia, past history of diseases of the thymus myasthenia gravis, thymoma, cases of absence of thymus or removal surgical.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-3hvsy5	Single implant-retained removable mandibular complete denture: non randomized controlled clinical study	Not yet recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3947	Single implant-retained mandibular overdenture: non-randomized controlled clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3hvsy5	<NULL>	Patients must be 60 years or older, good general health status, absence of intraoral lesions, and changes in the perioral muscles detected by palpation. Patients whose implants can be placed in the mandible without bone graft (minimum bone height of 8 mm), user of the upper conventional complete denture, use or nonuse the lower complete denture, and need new conventional complete dentures.	Edentulous with local bone deficiency, systemic disease that prevents implant placement, history of chemotherapy or radiotherapy, users of bisphosphonate drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5c3tb9	Bacterial adherence to silk and nylon suture	Data analysis completed	Intervention	2020-06-24	<NULL>	<NULL>	3948	"Efficacy of antiseptic ointment in preventing of
bacterial contamination on suture"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5c3tb9	<NULL>	Moth genders. Older than 18 years. With indication of extractions of minimum of two teeth in both hemiarchs of the same dental arch.	Patients with systemic diseases. Patientes with  local changes sugestinf infecction. Patients allergic to the components of the ointment. Patients with reports of antimicrobial use in the last 15 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5xbwjk	Transcranial stimulation applied to fibromyalgia	Data analysis completed	Intervention	2020-06-24	<NULL>	<NULL>	3949	Neuromodulation applied to fibromyalgia (neurofibro): double-blind, controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5xbwjk	<NULL>	Having a diagnosis of fibromyalgia, according to the criteria of the American College of Rheumatology; having been diagnosed at least three months ago; be female; be in the age group between 27 and 58 years old; and signing the Informed Consent Form.	Score below 24 on the Mini Mental State Examination; metal implants located on the head; cochlear implants and cardiac pacemaker; illiterate; pregnant women; history of seizure; and severe depression with a score greater than 35 in the Beck Depression Inventory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-65rzrv	Comparative study between Diode Laser Surgery and Filtering Surgery as a Primary Surgical Procedure for patients with Glaucoma	Recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3950	A Prospective randomized multicenter study comparing Transscleral Cyclophotocoagulation and Trabeculectomy as a Primary Surgical Procedure in Glaucoma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-07	Centro de Referência em Oftalmologia da Universidade Federal de Goiás (CEROF-UFG)	Centro de Referência em Oftalmologia da Universidade Federal de Goiás (CEROF-UFG)	https://ensaiosclinicos.gov.br/rg/RBR-65rzrv	<NULL>	"The study will include patients aged over 18 years with the following glaucoma subtypes: POAG, pigmentary glaucoma (PG), pseudo-exfoliation glaucoma (PEX), and cortisone glaucoma. The patients must have glaucoma refractory to clinical treatment and not in the target IOP, defined by the physician responsible for the case or with VF progression (22) confirmed with the current IOP.
All patients must have at least one reliable SITA Standard 24-2 VF exam (Humphrey Systems, Dublin, CA, USA) and with characteristic glaucoma changes according to the criteria proposed by Hodapp-Parrish-Anderson (HPA) (23), OD examination showing typical glaucoma lesion, i.e., neural rim focal thinning or global loss, vascular changes, and/or localized RNFL defects (24), and the ability to perform VF testing in at least one eye.
Pseudo-phakic patients must have a history of a previous cataract surgery using the phacoemulsification technique (PHACO ) with a corneal incision without stitches and intraocular lens (IOL) implantation within a capsular bag and without complications described in the patient’s medical chart and/or confirmed with detailed examination of the eye in mydriasis."	"Exclusion criteria will be as follows: absence of light perception vision; loss or deficit of vision in any eye of unknown cause or other than glaucoma; unreliable VF; aphakia or any other changes at biomicroscopy or ophthalmoscopy that may affect VF examination, such as age-related macular degeneration (AMD) or retinal detachment (RD); or recent participation in another research protocol (six months). VF will only be an inclusion criterion for patients with corrected VA better than 20/200. Patients below this level will not undergo the VF exam to be included in the study.
Pregnant or lactating patients will be excluded from the study. Patients with a history of any other intraocular surgery (except cataracts, as previously described); previous anti-glaucoma surgery (any technique); need for other surgeries concomitant with glaucoma surgery, such as for cataracts; aphakia; history of cataracts with complications, such as posterior capsule rupture, vitreous loss, or IOL implantation in the groove; conjunctival scars that may prevent or hinder TREC, such as sequelae from burns or pterygium surgery; corneal scars that may hinder the IOP measurement; or history or evidence of uveitis (active or not) will also be excluded.
Patients with ocular hypertension, normal pressure glaucoma (NPG), PCAG, neovascular glaucoma (even treated), congenital or juvenile glaucoma, endothelial iridocorneal syndrome, traumatic glaucoma, secondary glaucoma, or any conditions that, at medical discretion, will contraindicate any of the techniques proposed in the study will also be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-66tr7h	Systemic Effect of Periodontal Therapy on Risk Markers of Acute Cardiovascular Events	Recruitment completed	Intervention	2020-06-24	<NULL>	<NULL>	3951	Systemic Effect of Periodontal Therapy on Risk Markers of Acute Cardiovascular Events	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66tr7h	<NULL>	Patients will be selected based on the free demand of the Graduate Clinic of the Faculty of Dentistry of Ribeirão Preto. Sixty patients will be invited to participate in the study and will sign an informed consent form (TCLE) containing information about the objectives, risks and benefits of the study. All patients should have at least 14 natural teeth, at least 4 of them molars with at least 4 pockets with probing pocket depth greater or equal to 4 mm and 6 sites with clinical attachment level greater than 3 mm.	Patients with chronic inflammation or immunological conditions, such as arthritis, heart and kidney disease, smoking history, pregnancy and use of medication such as anti-inflammatories, antibiotics, immunosuppressants, or anticoagulants, will be excluded. Patients who withdraw from participating in the survey or who are unable to attend scheduled appointments will be excluded from the study, but they will continue to receive the necessary periodontal treatment. Special care will be taken for cardiac evaluation. The risk of cardiovascular events will be assessed previously in all patients selected according to the Brazilian Cardiology Association, where factors such as smoking, hypertension, overweight/ obesity, dyslipidemia, regular physical activity and psychosocial factors are evaluated (Simão et al., 2014). Patients who come into the medium or high-risk categories will be excluded from the study and instructed to look for specialized medical care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-6mdxfq	Prevention of caries in teeth appliances: comparison of the effect of fluoride and xylitol dental gel	Recruitment completed	Intervention	2020-06-25	<NULL>	<NULL>	3952	Prevention of white spot lesions in orthodontics: comparison of efficacy of fluoride varnish and xylitol varnish	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-15	Faculdade de Odontologia de Bauru/FOB/USP	FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6mdxfq	<NULL>	The inclusion criteria were patients undergoing comprehensive orthodontic treatment 1 to 6 months before study commencement, with 11 to 17 years of age, from both sexes, with complete permanent dentition.	The exclusion criteria were patients with cavitated dental caries, developmental enamel alterations (enamel hypoplasia and fluorosis), and use of antibiotics during the follow-up period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8jcwjp	Comparative study of the effect of the intervention of real Transcranial Led Therapy and placebo, on anxiety and depression with patients with TBI.	Recruiting	Intervention	2020-06-25	<NULL>	<NULL>	3953	Prospective randomized, double-blind, placebo-controlled study of the effects of the Transcranial Led Therapy Intervention (TLT) on anxiety and depression in patients with traumatic brain injury (TBI).	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Centro Universitário UniFacid	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8jcwjp	<NULL>	subject between 18 and 60 years old; ability to understand and follow instructions in Portuguese; Glasgow Coma Scale of entry equal to or greater than 12; TBI time from 3 months.	subjects under 18 or over 60; limiting language and / or motor impairment; non-signature of the informed consent form, presence of important bone defects in the regions of the skull to be stimulated, presence of epilepsy after uncontrolled TBI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-2tq5dp	influence of chitosan on dental erosion. Clinical and photographic evaluation of restorations.	Recruitment completed	Intervention	2020-06-25	<NULL>	<NULL>	3954	Influence of biomodification with Camellia sinensis encapsulated on chitosan nanoparticles on eroded dentin. Clinical and photographic longitudinal analysis of restorations.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2tq5dp	<NULL>	Patients with at least four non-carious erosive lesions; age between 20 and 50 years; shallow or medium lesion depth; dental erosion lesions on the palatal, lingual, occlusal or incisal surfaces of two homologous teeth.	patients who had teeth with spontaneous pain or tenderness; presence of fistula; presence of edema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-2d2vb9	Pilates in patients with Persistent Pain	Not yet recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3955	Pilates in patients with Chronic Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Faculdade de Medicina da Universidade Federal do Ceará	Faculdade de Medicina da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2d2vb9	<NULL>	The study will include individuals aged between 18 and 60 years, of both sexes, who have had low back pain for more than 12 weeks.	Individuals contraindicated for therapeutic exercise, according to the Physical Activity Readiness Questionnaire, who underwent treatment with Pilates in the last 3 months, pregnant women, severe spinal pathologies (example: fracture, tumor, infection), previous spinal surgery and lower limbs, inflammatory, rheumatic or neurological disorders, nerve root involvement, osteoporosis, inability to understand written or spoken Portuguese and who has received physical therapy in the past 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8m62y2	Effects of respiratory muscle training on the quality of life of hemodialysis patients	Recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3956	Effects of powerbreathe® on hemodialysis quality of life: blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8m62y2	<NULL>	"Adult subjects between 18 and 70 years old;
Regular hemodialysis at least 3x a week for at least 6 months;
Do not practice any type of physical exercise;
Having signed the informed consent form (ICF)."	"Uncontrolled systemic arterial hypertension (SAH);
Ischemic heart disease;
Amputation;
Deep vein thrombosis;
Severe dyspnea;
Femoral fistula;
Chronic obstructive pulmonary disease (COPD) stage 3 (severe);
decompensated congestive heart failure (CHF);
Cardiac arrhythmia;
Severe pneumopathy;
Acute systemic infection;
Pregnancy;
Decompensated diabetes mellitus;
Any orthopedic, neurological or cognitive impairment that compromises the understanding and execution of kinesiotherapy programs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4wnx2q	Pulmonary rehabilitation in individuals affected by Covid-19	Recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3957	Evaluation, pulmonary rehabilitation and follow-up of individuals affected by Covid-19 after hospital high - treatment and clinical follow-up	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-06	Universidade Estadual do Centro Oeste	Universidade Estadual do Centro Oeste	https://ensaiosclinicos.gov.br/rg/RBR-4wnx2q	<NULL>	Individuals over 18 years old; diagnosis of Covid-19 confirmed and cured, With clinical stability	Patients who do not accept to participate in the research, patients with Covid-19 still in the isolation period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8g7xdv	Influence of stress on gastroesophageal reflux disease.	Recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3958	Influence of stress on symptoms of gastroesophageal reflux disease in adult patients.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-19	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8g7xdv	<NULL>	"Adults between 18 and 65 years of both genders.
Preserved ability to understand.
Having signed the free and informed consent form before data collection.
Have symptoms of GERD with EDA results, esophageal manometry and prolonged pH monitoring."	"Adults with diagnosed psychiatric illness
Make use of psychotropic drugs
Neurological disease, neoplasms
Grade III obesity
Patients with cognitive impairment
Illiterate patients
Patients with severe visual impairment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-7t6ycp	Physical Exercises Compared to Guidelines in Patients with Jaw Joint Dysfunction	Data analysis completed	Intervention	2020-06-26	<NULL>	<NULL>	3959	Physical Exercises X Orientations in Patients with Temporomandibular Joint Displacement: Randomized controlled blinded clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7t6ycp	<NULL>	Volunteers over the age of 18, with disc displacement with reduction, who sought the TMD clinic at the Federal University of Vales do Jequitinhonha and Mucuri and who agreed to participate in the study by signing the Free and Informed Consent Form Informed Consent Form.	Edentulous participants, patients who have previously been treated for TMD treatment and patients with systemic diseases that could cause joint and / or muscle changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-29x8qk	Safety, Feasibility and Cardiovascular Benefits of a Home-Based Exercise Program in Patients with Sickle Cell Disease	Recruitment completed	Intervention	2020-06-27	<NULL>	<NULL>	3960	Safety, Feasibility and Cardiovascular Benefits of a Home-Based Exercise Program in Patients with Sickle Cell Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio de Mesquita Filho	faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-29x8qk	<NULL>	Patients with sickle cell disease; over 18 year,  with no sickle cell crise at least 30 days before the beginning of the exercise protocol; who agreed to participate in the study and signed an informed consent form.	Patients who did not agree to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5kkpg6	Effect of eating habits and exposure to light on sleep, emotion, memory and headache in college students during the COVID-19 pandemic	Not yet recruiting	Intervention	2020-06-28	<NULL>	<NULL>	3961	Interaction of food and light synchronization on sleep aspects, cognition and headache in college students during the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5kkpg6	<NULL>	College students regularly enrolled in higher education institutions; both sexes, between 18 and 30 years of age; in social isolation, leaving your home only for essential activities.	Students from colleges, originally with a distance learning method; students from international colleges.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-2b23xm	Evaluation of the position of the mandible after application of BOTOX in patients with disorders in the mandibular joint: a randomized study	Recruiting	Intervention	2020-06-29	<NULL>	<NULL>	3962	Condylar position evaluation after application of Botulinic toxin in patients with muscular TMD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Centro Universitário Hermínio Ometto - Uniararas	Centro Universitário Hermínio Ometto - Uniararas	https://ensaiosclinicos.gov.br/rg/RBR-2b23xm	<NULL>	Female volunteers; aged 18 to 50 years old; at least 28 healthy dental elements; previously diagnosed with  Muscular temporomandibular dysfunction according to the DC / TMD axis I; class I Angle classification; at least 4 of the six occlusion keys described by Andrews.	Class I and III of Angle classification patients, individuals undergoing orthodontic treatment, systemic diseases or pathologies associated with the stomatognathic system that are functional limitations, patients with posterior and / or anterior tooth loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-7jqpnw	Effect of COVID-19 convalescent plasma produced by HEMOPE: A randomized study, with a comparative group in several centers	Not yet recruiting	Intervention	2020-06-29	<NULL>	<NULL>	3963	Therapeutic effectiveness of COVID-19 convalescent plasma produced by HEMOPE: a multicenter, randomized and controlled clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7jqpnw	<NULL>	adults&gt; 18 years with diagnosis of COVID – 19, who are hospitalized; and considered as having a condition that increases the risk of a worse prognosis: obesity; diabetes mellitus (DM); systemic arterial hypertension (SAH); chronic lung disease, obesity, diseases that alter immunity (AIDS, neoplasms or autoimmune diseases in immunosuppressive therapy, chronic liver disease.	History of anaphylactic reaction related to blood transfusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4pphkf	Effectiveness of prayer in chronic kidney patients	Data analysis completed	Intervention	2020-06-30	<NULL>	<NULL>	3964	Effectiveness of prayer on chronic kidney disease patients on hemodialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pphkf	<NULL>	Age over 18 years, literate, clinically stable and oriented about time and space when reaching 24 or more points in the Mini Mental State Exam.	Presence of deafness, as it was decided to apply the prayer with the aid of headphones; present limitations that compromised speech; and who have used anxiolytics within 24 hours prior to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8zxttb	Long-term clinical evaluation after surgical treatment of patients with Hirschsprung&apos;s Disease, associated or not, with Type B Intestinal Neuronal Dysplasia	Recruiting	Observational	2020-06-30	<NULL>	<NULL>	3965	Long-term clinical evaluation after surgical treatment of patients with Hirschsprung&apos;s disease: does the association of type B intestinal neuronal dysplasia worsen the results?	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-09-19	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	Pedro Luiz Toledo de Arruda Lourenção	https://ensaiosclinicos.gov.br/rg/RBR-8zxttb	<NULL>	"Patients under 15 years at the time of diagnosis and surgical treatment;
diagnosis of HD previously established by histopathological analysis of rectal biopsies and confirmed by histopathological analysis of surgical specimens; minimum time of 5 years after surgical treatment; agreement to participate in the study and signing the consent and consent terms."	"Aganglionosis region extending beyond the sigmoid colon (long forms of HD);
associated diagnosis of other intestinal dysganglionoses, besides HD and DNI-B, in the histopathological analysis of surgical specimens; patients who had perioperative complications, which could potentially influence long-term functional bowel outcomes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-5tfrhv	Comparison of single-dose preoperative Ibuprofen vs. Ibuprofen with Arginine in the control of postoperative pain in canal treatments	Recruitment completed	Intervention	2018-11-08	<NULL>	<NULL>	3966	Preoperative single-dose comparison of Ibuprofen versus Ibuprofen with Arginine in postoperative pain control in Endodontics: Double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-05	Universidade Estadual de Ponta Grossa	Centro de Ensino Superior dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5tfrhv	<NULL>	Men or women between 20 and 59 years of age in good health; Satisfy ASA I or II medical history according to the American Society of Anesthesiologists; Need for endodontic therapy in uni or multi-root teeth, asymptomatic with necrotic pulp; Volunteers who can provide informed consent.	Men or women under 20 years of age; Pregnant or lactating women; History of allergy or hypersensitivity to ibuprofen, arginine or local anesthetics; Need for antibiotic prophylaxis; Gastrointestinal disorders, esophageal reflux; Active asthma; Decreased hepatic function; Bleeding disorders; Decompensated diabetes mellitus; Ingestion of analgesics and anti-inflammatories in the last 12 hours (as it may exert a therapeutic effect at the time of the study); Intake of alcoholic beverage in the last 24 hours;Individuals classified as class III to V according to the American Society of Anesthesiologists; Individuals unable to provide informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-537s3c	Sensory analysis of functional cooking recipes designed for students from 09 to 15 years from Campinas / SP	Data analysis completed	Observational	2020-07-01	<NULL>	<NULL>	3967	Evaluation of the acceptance of healthy recipes developed for students between 09 and 15 years of Campinas / SP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Rosana Gomes Arruda Leite Bueno	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-537s3c	<NULL>	Be a student enrolled in a municipal school; have between 9 and 15 years old.	Not having signed the consent or agreement term; have sensitivities, allergies or intolerance to any of the ingredients used in the preparations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-9xmfyq	"Botulinum Toxin type A for the treatment of 
smile with gum exposure"	Data analysis completed	Intervention	2020-07-01	<NULL>	<NULL>	3968	Evaluation of different doses of botulinum toxin type A for the treatment of gingival smile	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-08	Centro Brasileiro de Estudos em Dermatologia	Centro Brasileiro de Estudos em Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-9xmfyq	<NULL>	"Individuals aged between 18 and 70 years;
Superior anterior gingival exposure: more than 4 mm, for subjects included in group A and 2 to 4 mm, for subjects included in group B;
Presence of at least one indication for cosmetic treatment with botulinum toxin in the upper face;
Medical history and physical examination that, in the opinion of the investigator, does not interfere with the progress of the study;
Women of childbearing potential should have a negative urinary pregnancy test at visit 1. These subjects should use a highly effective contraception method during the study: combined oral contraceptives [estrogen and progesterone] or implanted contraceptives (with a stable dose for at least 1 month prior to study entry), bilateral tubal ligation, hormonal intrauterine device (inserted at least 1 month prior to study entry), strict abstinence (at least 1 month prior to entry into the study and agree to continue for the duration of the study), or vasectomized partner (at least 3 months prior to study entry) or use of condom;
Women presenting for childbearing potential (e.g. before menstruation, post menopause (absence of menstrual bleeding for 1 year before entry into the study), hysterectomy, or bilateral ovariectomy, less than one year postmenopausal);
Willingness to comply with protocol requirements and study duration.
Understanding and signing the Informed Consent Term (ICF) at baseline, before any study procedure is performed."	"Pregnant and/or breastfeeding women, or women who wish to become pregnant during the study period;
Any surgical intervention that has affected the area evaluated in this study;
Any cosmetic procedures, including fillers, or scars that may interfere with the results of the study;
Previous treatment with botulinum toxin for gingival smile less than 6 months ago, or for other indications on the face less than 12 months ago;
Evident facial asymmetry;
Active inflammation or infections in the treated areas;
Neoplastic, muscle or neurological diseases (e.g. Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome and motor neuron disease);
Serious psychiatric disorders;
Any other disease or chronic or serious decompensated medical condition that, in the opinion of the investigator, may interfere with the assessments or participation in the study or put subject at significant risk;
History of sensitivity to the formula components;
Current use of aminoglycoside antibiotics or penicillamines, quinines or calcium channel blockers or use at any time during the study;
Coagulation disorders or use of anticoagulants; 
Vulnerable subjects (such as those deprived of their liberty) as defined in Section 1.61 of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) for Good Clinical Practice (GCP);
Subjects with history of non-adherence to medications or showing difficulties to adhere to the study protocol;
Current participation in another drug or device clinical study OR participation within 30 days prior to Day 1 OR in a period of exclusion from a previous clinical study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-2499jt	Evaluation of microcirculation of the oral mucosa in patients undergoing chemotherapy and radiotherapy	Recruitment completed	Observational	2020-07-02	<NULL>	<NULL>	3969	Evaluation of microcirculation of the oral mucosa using laser doppler flowmetry in patients receiving chemotherapy and radiotherapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-21	Universidade de São Paulo - Campus Bauru	Universidade de São Paulo - Campus Bauru	https://ensaiosclinicos.gov.br/rg/RBR-2499jt	<NULL>	Diagnosis of malignant tumor; Therapeutic regimen associated with high risk of developing oral mucositis; Standard chemotherapy and or head and neck radiation therapy; Age over 18 years; Control group healthy individuals	Pregnancy; Diabetic; Patients with uncontrolled systemic arterial hypertension	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-888t7r	Comparation between Elixir Sanative® and Chlorexidine mouthwash in cicatrization after tooth extractions	Data analysis completed	Intervention	2020-07-02	<NULL>	<NULL>	3970	Comparative study of Elixir Sanative® and Chlorexidine in alveolar cicatrization	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-888t7r	<NULL>	healthy patients; with an indication for tooth extraction contralateral without the requirement for osteotomy or odontosection.	"patients with pathologies
systemic diseases; smokers; alcoholics;pregnant women; patients allergic to one or more drugs used and patients who used anti-inflammatory
or antibiotic in the last 07 days."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-3h5394	Walking program for elderly women with high blood pressure	Data analysis completed	Intervention	2018-11-06	<NULL>	<NULL>	3971	Walking program for elderly hypertensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-05	Hospital Universitario Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3h5394	<NULL>	Age between 60 and 75 years; women; body mass index lower than 35 kg/m2; physically inactive; previous diagnosis of hypertension; absence of any other cardiometabolic disorder or disease; no severe musculoskeletal problem that limits walking practice; signed consent form; medical clearing after physical exercise test	Change in medication during the study period; withdrawal the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-9dxqbk	Comparison of Leucine-Rich Alpha-2-Glycoprotein-1 (LRG-1) blood Levels Between Patients With and Without Appendicitis	Recruitment completed	Observational	2020-07-02	<NULL>	<NULL>	3972	Diagnosis of Appendicitis by Analysis of Peripheral Blood - Project APPENDIX	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9dxqbk	<NULL>	Recent abdominal pain (less than 30 days) with at least one more of the other criteria; pain in the right iliac region; pain migrating; nausea or vomiting before vomiting; psoas sign; fever; rebound tenderness (Blumberg sign); abdominal rigidity; no previous similar pain; pain to digital rectal examination; anorexia.	Refusal to participate in the study; have already undergone appendectomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-86ksrj	Effects of Aromatherapy on labor: A triple blind randomized clinical trial	Data analysis completed	Intervention	2020-07-03	<NULL>	<NULL>	3973	The use of aromatherapy in humanized labor	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2018-12-05	universidade federal do piaui	universidade federal do piaui	https://ensaiosclinicos.gov.br/rg/RBR-86ksrj	<NULL>	Pregnant women in active labor; of age; term pregnancy; In spontaneous labor; live fetus, fetus with cephalic apex presentation, fetus with good vitality conditions.	Pregnant women in latent labor; pregnant women who had an indication for cesarean delivery at admission; pregnant women who had clinical complications; pregnant women with changes in amniotic fluid and presence of fetal malformation; pregnant women in labor induction or with indication for uterotonic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-3bt9sb	Ankle range of motion assessment in professional soccer players	Data analysis completed	Observational	2020-07-03	<NULL>	<NULL>	3974	Ankle Test application in the assessment of ankle range of motion in professional soccer players	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	universidade federal de sergipe	universidade federal de sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3bt9sb	<NULL>	SUB-19 football players who are enrolled in the 2019 Sergipe championship	Not being entered in the competition or having an injury on the day of the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-72sc84	Effects of frequent exercise with supervised weight done in hospitals and gyms on Muscle Strength, weight of muscles, bones, organs and body fluids and control of glucose, triglyceride and cholesterol values in women with type 2 Diabetes with muscle weight loss after to stop menstruating	Recruiting	Intervention	2020-07-06	<NULL>	<NULL>	3975	Effects of the regular performance of Supervised Resistance Training performed in a hospital and gym environment on Muscle Strength, Lean Mass and Metabolic Control in Type 2 Sarcopenic Diabetic women in the post Menopause period	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	Faculdade de Ciências Médicas de Pernambuco	PPGCS/UPE - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-72sc84	<NULL>	Female patients, in the postmenopausal period, diagnosed with type 2 diabetes mellitus, with variations in the levels of glycosylated hemoglobin and are classified as being sedentary or irregularly active according to the International Physical Activity Questionnaire (IPAQ).	Past coronary or cerebrovascular event; carriers of chronic kidney disease with an estimated glomerular filtration rate less than or equal to 30 ml / min; orthopedic limitation for physical exercise; proliferative diabetic retinopathy; disabling diabetic neuropathy; NYHA class III or IV heart failure; established liver disease (Child B or C); decompensated thyroid disease; malignant neoplasm, except for basal cell carcinoma; in coronary, carotid or peripheral arterial revascularization schedule; documented myocardial ischemia; classified as active or very active by the International Physical Activity Questionnaire (IPAQ); participation in any training program using weights in the last 6 months; and with adherence to the systematic resistance training protocol below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-8yb47v	Effects of two exercise programs on pain, functionality and running pattern in runners with anterior knee pain	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3976	Effects of two gait retraining programs on pain, functionality and lower limb kinematics in runners with patellofemoral pain: a randomized clinical trial with 6-months follow-up.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8yb47v	<NULL>	Rearfoot runners with step rate under 170 steps/minute, age between 18 and 45 years, minimum pain levels of 3/10 on the Visual Analogue Scale (VAS) during running and one task among squatting, climbing, and descending steps, kneeling, and extending the knee with resistance, and being comfortable running at a speed of 10-12 km/hour.	Other diseases in the lower limbs, history of surgery in the lower limbs in the last year, and not showing interest to adhere to a strict running retraining protocol for 2 weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4dsvfy	Immediate effects on cervical mobility and spiratory flow after Bilateral Manipulation of the First Rib in Neck Pain	Recruiting	Intervention	2020-03-25	<NULL>	<NULL>	3977	Immediate effects on cervical mobility and maximum spiratory flow after Bilateral Manipulation of the First Rib in patients with Chronic Mechanical Cerlvicalgia ECA	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-10	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-4dsvfy	<NULL>	chronic neck pain	"Having acute, subacute or chronic respiratory disease.
Having diagnosed central or peripheral neurological disease.
Present costal and / or vertebral congenital alterations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-2tgh47	Incorporation of chlorhexidine into a soft relining resin for denture stomatitis treatment	Recruitment completed	Intervention	2020-07-06	<NULL>	<NULL>	3978	Incorporation of chlorhexidine into a soft relining resin for denture stomatitis treatment	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2016-09-02	Faculdade de Oodntologia da Universidade do Estado do Rio de Janeiro	Faculdade de Oodntologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2tgh47	<NULL>	Healthy individuals of both genders; users of total maxillary prosthesis for at least 1 year; who present with denture stomatitis in  mucosal areas underlying complete dentures. To participate in the research, patients must sign an informed consent form.	Immunocompromised patients with uncontrolled endocrinopathologies who use antibiotics and those undergoing radiotherapy or chemotherapy will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-6dv55j	Effect for the health, well-being and sleep of military personnel through ice cream containing beneficial bacteria	Recruitment completed	Intervention	2020-07-06	<NULL>	<NULL>	3979	Effect of Supplementation with Synbotic Ice Cream on the immune response, health in general and parameters related to the gut-brain axis in military submitted to field training	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-03-07	Faculdade de Ciências Aplicadas - Universidade Estadual de Campinas	Instituto de Tecnologia de Alimentos	https://ensaiosclinicos.gov.br/rg/RBR-6dv55j	<NULL>	Military student in Army Cadets Preparatory School (EsPCEx); aged between 18 and 22 years; participation in field training activities	Military with age below 18 years and above 22 years; lactose intolerance and allergy to milk proteins or to any of the other ingredients used in the product (emulsifier, vanilla extract, inulin); being immunosuppressed or having undergone any organ transplant, as well as any type of heart disease; antibiotic use by volunteers within 15 days before the start of supplementation; need for any type of surgery, tooth extraction or other types of dental manipulation, during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4qgwpq	Training on preparing to become pregnant alters the knowledge and actions of health professionals	Recruitment completed	Intervention	2020-07-06	<NULL>	<NULL>	3980	Effect of an educational intervention on knowledge about pre-conceptional workers among health workers in primary care and in performing pre-conceptional care actions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-10	Escola de Enfermagem da Universidade de São Paulo	Prefeitura de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qgwpq	<NULL>	Health workers, who work in primary care, in family health teams; doctors, and nurses.	There is no	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4wjnm9	Use of Muscle Strength Training at Heel Height	Recruiting	Intervention	2020-07-07	<NULL>	<NULL>	3981	Use of Isoinertial Training at the Height of the Vertical Jump	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wjnm9	<NULL>	Are not undergoing physical therapy for lower limbs; men; aged between 18 and 30 years.	Volunteers undergoing physical therapy treatment for lower limbs; lower limb pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-2ybgmp	Evaluation of inflammation in patients with chronic kidney disease using a bicycle exercise program during hemodialysis	Recruitment completed	Intervention	2020-07-07	<NULL>	<NULL>	3982	Evaluation of inflammatory parameters in patients with Chronic Renal Insufficiency submitted to a peridialitic aerobic exercise program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-04	Bruno Medeiros Guio	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2ybgmp	<NULL>	individuals 18 at 80 years old, with chronic renal disease in the dialysis phase in outpatient follow-up of the referred institution	Patients with cardiovascular diseases; neurological disorders; musculoskeletal and any other deficiencies that prevented the use of cycloergometer; with infectious inflammatory disease active in the last 6 months and patients submitted to hospital admission will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-584pt5	The effects of participants&apos; engagement on the efficacy of actions to practice Mindfulness meditation	Data analysis completed	Intervention	2020-07-07	<NULL>	<NULL>	3983	The effects of beneficiary&apos;s engagement on the efficacy of social interventions to practice Mindfulness	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	Centro de Pós Graduação e Pesquisa em Administração - CEPEAD - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-584pt5	<NULL>	Students regularly enrolled at Federal University of Minas Gerais	Subjects presenting acute episodes of major depression disorder; anxiety disorder; dissociative disorder; schizophrenia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7rmtzg	Effect of lipids associated with toothbrushing regarding teeth color alteration, surface roughness and microhardness - an in vitro and in situ study.	Data analysis completed	Intervention	2019-01-16	<NULL>	<NULL>	3984	Effect of phytosphingosine associated with toothbrushing regarding color alteration, surface roughness and microhardness of dental enamel - an in vitro and in situ study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rmtzg	<NULL>	Both genders; overall health status; with no oral pathologies; age between 20 and 35 years.	Use of removable prosthesis; use of orthodontic device;fluoride compounds use in the last two months; pregnant women; breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7k4wgt	Pilates applied to control nonspecific low back pain in university students	Data analysis completed	Intervention	2020-07-08	<NULL>	<NULL>	3985	Influence of a hybrid pilates exercise program in the treatment of chronic non-specific low back pain and quality of life in medical students.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-15	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7k4wgt	<NULL>	Medical school students were included in the study, who had low back pain, who had no history of spine surgery; history of spine fracture; inflammatory, rheumatic or neurological disorders; systemic metabolic disease; nerve root involvement; tumor; infection; osteoporosis; severe structural deformity; who did not undergo any type of physical rehabilitation through exercise in the last 3 months and who did not take pilates classes; who undertake to perform the exercises in person and at home, as established in the project.	Participants who would not participate in the study after signing the informed consent form would be excluded from the study; to develop or worsen the pain process as a result of the exercises; pregnancy; diagnosis of diseases listed in the inclusion criteria, after agreeing to participate, that contraindicated the performance of exercises; that initiated any type of exercise modality in the period destined for the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4pt6wp	Clinical and satisfaction results from the use of one or two dental implants for removable prostheses on implants	Recruitment completed	Intervention	2020-07-08	<NULL>	<NULL>	3986	Randomized clinical study with mandibular overdentures with one or two osseointegrated implants: prospective clinical and radiographic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4pt6wp	<NULL>	"Only patients presenting the following were considered eligible for the study:
	Ability to consent to the treatment proposed; Availability to participate in the evaluations throughout the study period; Complete edentulism for at least four months, with previous use of conventional full denture; Aesthetically and functionally acceptable traditional full dentures; Appropriate psychological and physical conditions for implant surgery; A medical release for the treatment proposed (in the case of patients with controlled systemic diseases); Age of 40 years or older."	"Patients presenting the following were excluded from the study:
	Previous history of irradiation; Systemic diseases or conditions that contraindicated implant surgery; Previous treatment with oral implants; Medical/psychiatric/neurological restrictions for implant surgery; History of oral bisphosphonate treatment; Interest in other types of treatment than those proposed by the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7q9nj8	Intuitive eating in the behavior and food consumption of obese individuals who are candidates for Stomach Reduction surgery	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3987	Intuitive eating in the behavior and food consumption of obese individuals candidates for Bariatric Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Marina Brito Campos	Marina Brito Campos	https://ensaiosclinicos.gov.br/rg/RBR-7q9nj8	<NULL>	Individuals aged 20 to 65 years; with grade two obesity with comorbidities or morbid obesity; who have an indication for bariatric surgery; literate	"Individuals with psychiatric illness; bariatric surgery; pregnant or lactating women; with simultaneous participation
in other programs of weight loss; not literate; with suicide attempt in the last year"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-8p4sy6	Lidocaine in reducing unwanted effects during awakening from general anesthesia and associated respiratory complaints	Recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3988	Lidocaine on reduction of emergence phenomena during general anesthesia and respiratory complaints after Tracheal Intubation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-27	Victor Cáppia	Universidade de Marília	https://ensaiosclinicos.gov.br/rg/RBR-8p4sy6	<NULL>	"Patients physical status ASA (American Society of Anesthesiologists) I and II.
Elective surgeries with an expected duration of 60 to 180 minutes.
General anesthesia with orotracheal intubation."	"Smoking.
Orotracheal intubation performed in more than 2 attempts.
Body mass index greater than 35 kg/m2.
Chronic use of corticosteroids.
Recent history of upper airway infection (less than 21 days).
Otorhinolaryngological or head / neck surgeries.
Risk of bronchoaspiration.
History of allergy to any of the drugs used in the protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-788y7c	Participation of the HPV virus in the appearance of laryngeal papillomas in patients from São Luís, Maranhão	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3989	Involvement of human papillomavirus in the progression of papillomatous lesions of the larynx in patients from São Luís, Maranhão	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	UNIVERSIDADE FEDERAL DO MARANHÃO	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-788y7c	<NULL>	Individuals of all ages, of both sexes, who underwent surgery to remove the papillomas.	Inadequate biological material (necrotic), scarce material	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-6nw7p8	Effects of cold water immersion after crossfit® practitioners: randomized, blind, controlled clinical trial	Recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3990	Effects of cold water immersion on recovery of indirect markers of muscle damage in crossfit® practitioners: randomized, blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6nw7p8	<NULL>	"Men and women, CrossFit® practioners;
age between 18 and 40 years old;
at least 6 years of regular physical practice;
practice CrossFit® at least 3 times a week;
have performed at least twelve WOD&apos;s the last 4 weeks;
have experience in Karen WOD;
do not have performed a Karen WOD the last 4 weeks; 
have participated in some Mixed Modalities Training competition (at least at local level);
do not present osteomyoarticular injury that prevent the WOD from being performed;
do not present cardiomyopathy, muscular dystrophy, neurological disease;
do not present pain in the lower limbs;
do not have hypersensitivity or ice allergy;
do not have Raynaud syndrome;
be in the period immediately after menstruation, in the follicular phase of the menstrual cycle (only for female participants)"	"Could not complete the exercise protocol in the assessment;
do not complete any of the study procedures for any reason;
make use of energy drinks, anabolic steroids, drugs, among other substances that can increase performance during the assessment period;
make use of analgesic, anti-inflammatory or central nervous system depressants during the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-3bq3gq	Cognitive training workshop for healthy elderly	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3991	Cognitive training workshop for elderly people without cognitive impairment: an Occupational Therapy intervention	<NULL>	3, non-randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal do Paraná	SETOR DE CIÊNCIAS DA SAÚDE DA UNIVERSIDADE FEDERAL DO PARANÁ	https://ensaiosclinicos.gov.br/rg/RBR-3bq3gq	<NULL>	Be 60 years old or more; Do not show signs of cognitive impairment; Do not have a depressive or suspected depression; Have an interest in participating in the cognitive training workshop for the duration of the same; Do not have severe visual impairment without optical correction; Not having severe hearing loss; Be literate.	Subjects who do not meet the inclusion criteria, and do not know how to read and write, as well as people with extreme difficulty in seeing and hearing even with the best correction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-5t258m	Analysis of Salivary Constituents of Elderly Patients with Gingivitis After Use of Dentifrice Incorporated with Brazilian Red Propolis	Not yet recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3992	Analysis of Salivary Biomarkers in Elderly Patients with Gingivitis After Use of 1% Brazilian Red Propolis Based Dentifrice: A Randomized Clinical Trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5t258m	<NULL>	Healthy volunteers; both genders; presence of gingivitis; age over 65 years; presence of at least five dental elements.	Smoking volunteers; history of alcohol or drug abuse, presence of cognitive problems; dependency on caregiver for daily activities; professional application of fluoridated products in the last 3 months; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4n7j6h	The effect of Bee Honey With and Without Propolis in reducing the occurrence of Respiratory Problems in malnourished children treated at CREN	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	3993	Efficacy of Honey Abelha With and Without Propolis in Respiratory Events in Malnourished Children treated at CREN	<NULL>	2-3, non-randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2010-09-01	Telma Maria de Menezes Toledo Florêncio	Centro de Recuperação e Educação Nutricional - CREN	https://ensaiosclinicos.gov.br/rg/RBR-4n7j6h	<NULL>	Children with primary malnutrition (&lt;-1.5 Z-score stature/age) in monitoring semi-boarding school in the Center for Recovery and Nutrition Education.	Children without malnutrition and 72 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-8k54cz	Effect of vagus nerve stimulation and physical exercise on cardiovascular, metabolic and cognitive responses in people with HIV	Recruitment completed	Intervention	2020-07-09	<NULL>	<NULL>	3994	Effect of Auricular Transcutaneous Electrostimulation of the Vague Nerve and Physical Exercise on the cardiovascular, metabolic and cognitive parameters of people living with HIV / AIDS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8k54cz	<NULL>	Individuals will need to present a medical certificate clearing the practice of physical exercise, be aged between 18-60 years, present a number of TCD4 lymphocyte cells equal to or above 350 cells / mm³ of blood and enroll as participants in the “VIVER +” project.	Individuals who do not have conditions to carry out the protocol and the evaluations during the research, have opportunistic injuries or infections, have undergone cardiac surgery or have heart disease, are currently dependent on illicit drugs, have serious medical disorders and / or have less than 75% will be excluded. attendance at physical exercise sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-93rvm9	Evaluation of dental extraction technique with minimally traumatic extractor	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	3995	Evaluation of surgical technique with minimally traumatic extractor	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-24	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-93rvm9	<NULL>	The criterion for inclusion of patients in the study was the presentation of at least one residual root or indication of exodontia (teeth severely destroyed to the point of rendering their restoration unfeasible, or by prosthetic indication). These teeth could be of the maxilla or jaw (excepting the molars), that is, incisors, canines and premolars. In addition, the individual should agree to participate in the study by signing the TCLE.	The exclusion criteria consisted basically of patients with some factor that contraindicated the surgical procedure, such as: infection installed at the site; uncontrolled systemic disorders, such as diabetes and hypertension; problems in the coagulation cascade; severe anemia; allergies; patients who used some medicine with interference in bone metabolism; pregnant patients; and patients who used drugs that stimulated gingival augmentation (antihypertensives, anticonvulsants, calcium channel blockers, among others), asthmatic patients without the opinion of the penumatologist and patients who had recently had Chikuncunha.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-3rywwg	A clinical, randomized study to evaluate the efficacy and safety of Naproxen compared to placebo in combination with Azithromycin or Levofloxacin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	Recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3996	A phase IIb, double-blind, randomized controlled trial to evaluate the efficacy and safety of Naproxen compared to placebo in combination with Azithromycin or Levofloxacin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Medicina de São Jose do Rio Preto - FUNFARME/FAMERP	Hospital de Base de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-3rywwg	<NULL>	"Men or women, 18 years of age or older
Ability to provide informed consent signed by study patient or legally acceptable representative
Requires ICU hospitalization.
Respiratory sign or symptom (cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose
Need for oxygen support using a nasal catheter up to 6 l / min to keep SaO2 above 94% or SpO2 &lt;94% in room air.
Bilateral infiltrate at Rx or signs suggestive of COVID-19 pneumonia on chest tomography;
Less than seven days after the first flu-like symptom."	"Need for oxygen support in a nasal catheter over 6 l / min to maintain SaO2 above 93% or signs of respiratory distress for more than 6 h;
Patient intubated and on mechanical ventilatory support;
Need for vasopressor or signs of shock;
Chronic renal failure or AKI Kdigo I or greater;
History of bleeding or recent peptic ulcer 6 months;
Suspected infections suggestive of fungal or bacterial etiologies;
Chronic hepatitis C infection in antiviral therapy;
Severely immunocompromised in the investigator&apos;s opinion (eg, differentiation cluster count 4+ [CD4 +] less than 200 cells / mm3, absolute neutrophil count less than 750 / mm3, first chemotherapy cycle completed in the 2 weeks prior to screening, history of stem cell transplantation within the period of 1 year prior to screening, any history of solid organ transplantation;
Pregnant women;
Patients with a life expectancy of less than 30 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7jrxqm	Effect of a special nutritional oral supplement use on inflammation in patients with COVID-19	Recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3997	Effect of oral supplement use with immunonutrients on inflammatory response in patients with COVID-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7jrxqm	<NULL>	Patients with the following criteria will be included: adults aged between 18 and 65 years, diagnosed with Covid-19 by molecular examination (RT-PCR), with pervious gastrointestinal tract, using oral diet and who are not on mechanical ventilation or requiring icu admission.	Pregnant patients; who have undergone the use of artificial nutrition in the 15 days prior to inclusion in this study; patients allergic to any components of the diets used; with severe hyperglycemia(greater than  180mg/dl) or hypertriglyceridemia (greater than  400mg/dl); with previous gastrointestinal diseases (surgical resections, malabsorption syndromes, inflammatory bowel diseases, persistent paralytic ileus, upper gastrointestinal bleeding or severe acute pancreatitis); with neutropenia-defined immunosuppression states, myelodysplastic syndromes, congenital immunodeficiency, or Acquired Immunodeficiency Syndrome (AIDS), immunosuppressive therapies in the last 03 months, systemic chemotherapy in the last 03 months, autologous bone marrow transplantation in the last year, halogenic bone marrow transplantation in the last 02 years, or existence of graft versus host disease (DEVH); with advanced chronic diseases (Child-Pugh stage C, grade IV heart failure (NYHA), chronic functional stage lung failure IV, terminal degenerative neurological processes, neoplasms in remission or progression over treatment); with processes with short life expectancy including end-stage chronic kidney disease; with acute processes that determine small survival as shock of any etiology with multiple organ dysfunction refractory to therapy in the first 48h or post-resuscitation severe neurological damage within 72 hours will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-28yb2g	Evaluation of postoperative pain from TMJ surgery and dexamethasone infiltration	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3998	"Evaluation of postoperative pain in patients undergoing joint arthroscopy
mandibular temporalis with infiltration of dexamethasone disodium phosphate in
different isolates"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-10	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-28yb2g	<NULL>	patients needing surgery; arthroscopic TMJ, temporomandibular disorders with Wilkes stages III and IV (Wilkes 1989) caused any of these pathologies: degenerative joint disease; synovitis; painful hypermobility; recurrent dislocation of disc cause; hypomobility caused by intra- articular; inflammatory arthropathies	skin or joint infection tumors ankylosis diabetic neuropathies; fibromyalgia and / or neuromuscular diseases; multiple sclerosis; also patients allergic to dexamethasone; unilateral TMJ surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-92g625	Aesthetic treatment of stains on anterior teeth caused by hypomineralization	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3999	Masking enamel demarcates opacities in anterior teeth in patients with Molar-Incisor Hypomineralization: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-25	Universidade do Estado do Rio de Janeiro -UERJ	Universidade do Estado do Rio de Janeiro -UERJ	https://ensaiosclinicos.gov.br/rg/RBR-92g625	<NULL>	The sample will be composed of children and adolescents, between 7 and 18 years old, with MIH, presenting white-creamy opacities in the enamel of at least one incisor	Patients with other dental developmental defects such as amelogenesis, dentinogenesis imperfecta or fluorosis; Patients with fixed orthodontic appliance; Patients with chronic health syndromes or health impairments that requires special care during dental treatment; Incisors with caries lesions or with demarcated opacities of other origins, such as traumatic sequelae in the predecessor primary teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-8zfn5c	Effect of daily consumption of Castanha-do-Pará (BERTHOLETIA EXCELSA, HBK) on weight loss, metabolism, appetite, food intake, metabolism regulators and genetic markers	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	4000	Effect of Brazil Nuts (BERTHOLETIA EXCELSA H.B.K) daily consumption on weight reduction and body composition, energy metabolism, appetite, food intake, metabolic regulators and genetic markers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8zfn5c	<NULL>	Adult women aged 20 to 55 years; excess body fat (equal or greater than 32%) and high waist circumference (equal or greater than 80 cm); overweight (BMI equal or greater than 27 kg/m2) associated with at least one more component of the Metabolic Syndrome, which means triglycerides equal or greater than 150 mg/dL, blood pressure equal or greater than 130 and/or  85 mmHg for systolic and diastolic pressures, respectively, or fasting glucose equal or greater than 100 mg / dL) or; obesity (BMI equal or greater than 30 kg/m2) regardless of the presence of the other components of the Metabolic Syndrome	Women younger than 20 years or older than 55 years; body fat percentage less than 32%; waist circumference less than 80 cm; BMI below 27 kg/m²; BMI between 27 and 30 kg/m², without the presence of any other component of metabolic synddrome, pregnant women, nursing mothers, or menopausal women; athletes; smokers; with a history of HIV, digestive alterations, hepatic or renal diseases, cardiovascular diseases, hypo or hyerthyroidism, cancer, inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; aversion or allergy to nuts; infectious episode in the last month; use of anti-inflammatory drugs, corticosteroids, antibiotics and others that can affect appetite and energy metabolism; weight instability (5% of usual weight) in the last 3 months; daily consumption of nuts (greater than 5g for Brazil nuts and greater than 30 g/day for other nuts); alcohol consumption higher than 21 units (168g) per week; dental problems that interfere with chewing; consumption of vitamin, mineral and omega 3 supplements in tha last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-6xqcr4	Assessment cardiorespiratory  in recovered Covid-19 patients	Recruiting	Observational	2020-07-10	<NULL>	<NULL>	4001	Cardiorespiratory fitness and neuromuscular performance in recovered Covid-19 patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	LETFAS-UFPB	LETFAS-UFPB	https://ensaiosclinicos.gov.br/rg/RBR-6xqcr4	<NULL>	Patients recovered from Covid-19 with mild to severe severity (recovery within 30 days) and people not contaminated by the coronavirus; both sexes; non smokers; 18 years old or older	Smoking volunteers; pregnancy; morbid obesity; diagnoses of cardiac, pulmonary, hematological, neurological or neuromuscular diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-3ksq2c	Immediate effects of Spinal Manipulation  on pain and balance in individuals with Chronic Low Back Pain	Not yet recruiting	Intervention	2020-07-13	<NULL>	<NULL>	4002	Immediate effects of Vertebral Manipulation on painful sensitivity and postural stability of individuals with Chronic Low Back Pain - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Centro Universitário Augusto Motta	UniGuairacá Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-3ksq2c	<NULL>	Low back pain lasting at least three months; score on the numerical pain scale of at least 3 points at the time of assessment; age between 18 and 59 years; hypomobility in at least one lumbar vertebral segment verified during the physiotherapeutic evaluation through the posteroanterior pressure test in the prone position (Spring Test); symptoms that do not extend beyond the knee; absence of neuropathic pain components assessed using the painDETECT questionnaire.	Chronic widespread pain; ligament laxity or hyper flexibility; pregnancy; conditions that contraindicate the use of vertebral manipulation techniques at high speed and low amplitude (red flags) such as vertebral fractures, cauda equina syndrome, cancer, inflammatory rheumatic diseases, vertebral infections, bone tuberculosis; any condition that may interfere with pain sensitivity measures, for example, changes in skin sensitivity, neurological diseases, psychiatric diseases or fibromyalgia; any condition that interferes with body balance, for example, neurological diseases or vestibulopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-45kf9p	CoV-Hep study : Comparative study between different anti-coagulation strategies in continuous hemodialysis in COVID-19 patients	Recruiting	Intervention	2020-07-13	<NULL>	<NULL>	4003	CoV-Hep study: Randomized and paired clinical trial comparing regional anticoagulation modalities in continuous venous venous hemodialysis in patients with COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-45kf9p	<NULL>	"Men and women aged 18 and over;

Confirmed or probable SARS-CoV-2 infection;

Presence of acute kidney injury with indication and agreement between ICU and nephrology teams for the introduction of renal continuous venous venous hemodialysis."	"Hypersensitivity to any of the substances used in the study (Citric acid dextrosol 2.2% and unfractionated heparin);

Previous diagnosis of coagulopathy or thrombophilia;

Contraindication to the use of unfractionated heparin by the assistant team;

Risk of citrate poisoning - (Lactate&gt; 30mg / dL, IRN&gt; 2.5, Total bilirubin&gt; 15mg / dL);

Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-4s5qcs	School Health: teaching, awareness and prevention of diseases caused by worms in students from public schools in João Pessoa, PB	Recruitment completed	Intervention	2020-07-10	<NULL>	<NULL>	4004	School Health: teaching, awareness and prevention of Enteroparasitosis caused by Helminths in students from public schools in João Pessoa, PB	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-04	Universidade Federal da Paraíba-UFPB	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4s5qcs	<NULL>	be a 6th or 7th grade student at the target school; Present a Free and Informed Consent Form (ICF) duly signed by parents or guardians and a Free; Informed Consent Form (ICF) signed	Present a cognitive deficit that would make it impossible to understand and participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7ymmrm	The influence of body positioning on the movement of the chest and abdomen of very low birth weight preterm infants	Recruitment completed	Intervention	2020-07-13	<NULL>	<NULL>	4005	The influence of body positioning on thoracoabdominal dynamics in preterm newborns with very low birth weight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Instituto Nacional de Saúde da mulher, da criança e do adolescente Fernandes Figueira	Instituto Nacional de Saúde da mulher, da criança e do adolescente Fernandes Figueira	https://ensaiosclinicos.gov.br/rg/RBR-7ymmrm	<NULL>	Newborns weighing less than 1500 grams; clinically stable	Newborns with congenital malformation of the chest, abdomen or face; newborns with grade IV intracranial hemorrhage; Newborns with congenital infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7q7gyd	Evaluation of the effect of laser irradiation on pain control in exposed dental roots	Recruitment completed	Intervention	2020-07-13	<NULL>	<NULL>	4006	Clinical evaluation of the effect of diode laser irradiation on exposed roots, associated or not with fluoride varnish, in the control of dentin hypersensitivity: Randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-7q7gyd	<NULL>	Healthy volunteers, both genders, aged between 18 and 50 years; present at least 1 tooth with an exposed root with sensitivity greater than 1 on the verbal response scale (RSV), measured after evaporative stimulus (air jet at 1 cm from the region to be analyzed); present gingival recession only on the buccal surface, of Miller class I or II types, with an extension between 2 and 5 mm.	Active caries lesions in any dental element; make chronic use of medications with analgesic, anti-inflammatory or drugs with central effect (anxiolytics and antidepressants); being under psychological counseling; make use of desensitizing agents (at home) in the last 3 months or in the office (6 months); pregnancy; allergy to any of the components of the treatments; being under orthodontic treatment; presence of removable or fixed prosthesis in the teeth under analysis; presence of Miller class III and IV recessions; patients with active periodontal disease; recession on the palatal and / or proximal surfaces; presence of furcation lesion in the selected teeth; daily use of mouthwash and mouthwashes (fluoride); presence of deep non-carious cervical lesions that need restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7drpyr	Effect of two covers to prevent injuries caused to professionals working in the health area due to the use of personal protective equipment	Recruitment completed	Intervention	2020-07-13	<NULL>	<NULL>	4007	Effect of two technologies in the prevention of pressure injuries associated with the use of personal protective equipment in health professionals in the face of the Covid-19 pandemic: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-20	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7drpyr	<NULL>	Professionals who provided direct assistance (doctors, nurses and physiotherapists) or indirect assistance (hygiene collaborators) to patients with suspected or diagnosed coronavirus; Professionals who needed to make continuous use (cap and particulate respirator) or intermittent use (face mask, gloves and apron) of PPE for six or 12 consecutive hours; Professionals who had no skin lesions on the face	Professionals who had some problem in sealing the N95 mask with the use of technology; Professionals who do not finish the shift; Professionals who needed to remove the cover due to discomfort or signs of allergy; Professionals who do not completely fill out the evaluation form received together with the LP prevention technology resulting from the use of PPE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7bxhrt	Chemoprophylaxis with chloroquine in a high-risk population for the prevention of SARS-CoV-2 infections  severity of infection.	Recruiting	Intervention	2020-07-14	<NULL>	<NULL>	4008	"Chloroquine chemoprophylaxis in a high-risk population for the prevention of SARS-CoV-2 infections severity of infection. Randomized clinical trial of
phase III"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-05-25	Instituto René Rachou/FIOCRUZ Minas	Centro de Pesquisa Clínica do Hospital das Clinicas (UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-7bxhrt	<NULL>	"Health professionals attending patients with suspected SARS-CoV-2 infection.
sign the informed consent.
Willing to adhere to the study protocol."	"Known allergy to the study drug (aminoquinolines).
flu-related symptoms at the time of inclusion.
Previous or current SARS-Cov2 infection confirmed.
Known pregnancy (no pregnancy test required).
History of retinopathy.
ECG changes with enlargement of the QT interval.
Weight less than 40 kg
Participant with any immunosuppressive condition or hematological disease.
Treatment with drugs that can prolong the QT interval or increase the number of adverse events in the last month before randomization for more than 7 days, including: azithromycin, chlorpromazine, cisapride, clarithromycin, domperidone, droperidol, erythromycin, halofantrine, haloperidol, lumefantrine, mefloquine, methadone, pentamidine, procainamide, cimetidine, quinidine, quinine, sotalol, sparfloxacin, thioridazine, amiodarone, Dapsone"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-23sqxz	Impact of cream vaginal use on complications in women using vaginal ring  in treatment of genital prolapse: a randomized clinical trial	Data analysis completed	Intervention	2018-08-24	<NULL>	<NULL>	4009	Impact of estrogen use on complications in women using vaginal pessaries with genital prolapse: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-25	Uiversidade Estadual de Campinas (Unicamp)	Uiversidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-23sqxz	<NULL>	Women with genital prolapse; Stage two, three and four prolap; to be using vaginal pessary	"hormone dependent neoplasms;
Not accepting to participate in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7nzxkm	Distal transradial access (in the anatomical snuffbox) as default for cardiac catheterization and coronary angioplasties	Recruiting	Observational	2020-07-15	<NULL>	<NULL>	4010	Distal transradial access as default approach for coronary angiography and interventions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-12	Hospital Regional do Vale do Paraíba (HRVP)	Universidade Federal De São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-7nzxkm	<NULL>	Patients referred for coronary angiography or percutaneous coronary interventios with any (even weak) palpable pulses in both proximal (wrist) and distal (anatomical snuffbox).	Patient refusal or absence of palpable radial pulses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-2h84gt	Evaluation of the effectiveness of Adhesive Tissue in the skin and mucosa of Perineal Tears	Recruitment completed	Intervention	2017-08-31	<NULL>	<NULL>	4011	Adhesive Tissue to Repair First-Degree Perineal Tears: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Escola de Enfermagem da Universidade de São Paulo	Pronto Socorro e Maternidade Zoraide Eva das Dores	https://ensaiosclinicos.gov.br/rg/RBR-2h84gt	<NULL>	to have up to 6 centimetres of cervical dilation at the time the woman is invited to participate in the research; Do not use steroid substances; Do not present leucorrhoea or any signs of infection at the repair site; No diagnosis of diabetes mellitus; without history of allergy to surgical glue or formaldehyde; No difficulty in understanding the Portuguese language or in communication; Accept being submitted to perineal repair methods with skin adhesive or suture thread.	Do not have vaginal delivery; Not having first degree laceration with indication of suture; Have episiotomy or laceration of second, third or fourth degree; Have physometry; have vulvar varicose veins; Have complications from the childbirth or postpartum requiring hospital transfer of the woman to a hospital of high complexity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-22k94c	Effectiveness of Active Video Games in adherence to ambulatory Cardiac Rehabilitation: randomized clinical trial	Not yet recruiting	Intervention	2020-07-16	<NULL>	<NULL>	4012	Effectiveness of Exergaming in adherence to Cardiac Rehabilitation Phase II: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-11	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-22k94c	<NULL>	Heart disease patients, of both sexes, over 18 years old, with medical clearance to perform CR.	Patients who had very recent acute myocardial infarction (less than 72 h); unstable angina (less than 72 h from stabilization); severe symptomatic valvular heart disease, with surgical indication; uncontrolled arterial hypertension: SBP greater than 190 mmHg and / or DBP greater than 120 mmHg; decompensated heart failure; complex ventricular arrhythmias; suspected left or unstable or severe coronary artery injury; infective endocarditis, myocarditis, pericarditis; severe, uncorrected, symptomatic congenital heart diseases; pulmonary thromboembolism and acute thrombophlebitis; aortic dissection - type A or acute phase type B; severe symptomatic obstruction of the left ventricular outflow tract with low effort-induced output; uncontrolled diabetes mellitus; acute systemic infectious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-3hg7mn	Mastication of denture wearers obese elderly	Recruiting	Intervention	2020-07-16	<NULL>	<NULL>	4013	Masticatory function of edentulous obese elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-28	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-3hg7mn	<NULL>	For the experimental group, partial edentulous elderly (equal or greater than 65 years) in at least one of the dental arches will be included, presenting the following criteria: good general health, or presence of properly controlled systemic diseases (such as hypertension and diabetes); diagnosis of obesity, according to anthropometric measurements and BIA parameters; normal salivary flow (equal or greater than 0.6 ml/min); absence of RPDs for at least 3 months. Elderly for the control group will be selected according to the same criteria, except for the presence of obesity.	Elderly smokers, with physical and/or cognitive impairments, presence of parafunctional habits, history of symptomatology of the temporomandibular joints and/or chewing muscles, elderly diagnosed with sarcopenia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-93996y	Effect of liquid and bar soap in healthy term newborns	Recruitment completed	Intervention	2018-07-13	<NULL>	<NULL>	4014	Effect of liquid and bar soap on skin in healthy term newborn: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-15	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-93996y	<NULL>	Newborns with gestational age at birth between 37 to 42 weeks and six days; from the Obstetric Center; with spontaneous breathing; with absence of congenital anomalies such as anencephaly, myelomeningocele, gastrocystic, spina bifida and dermatological diseases such as epidermolysis Bullosa impetigo neonatal ichthyosis, neonatal omphalitis	Newborns with neuropathies or diagnosed heart diseases after inclusion; transferred from the joint room to neonatal unit or intensive care unit after inclusion, exhibiting hypothermia (less than 36.5°C) or hyperthermia (greater than 38°C); in treatment with phototherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-62zdkk	Evaluation of immunity in the evolution of the severe or mild form of COVID-19	Recruiting	Observational	2020-07-17	<NULL>	<NULL>	4015	Immune biomarkers in the prognosis of COVID-19	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-06-12	Hospital Universitário de Brasília	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-62zdkk	<NULL>	patients of both genders; diagnosed with COVID-19; age over 18	do not fill out the informed consent form; age under 18 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7g48v7	respiratory muscle training in healthy subjects	Data analysis completed	Intervention	2020-07-17	<NULL>	<NULL>	4016	Respiratory muscle strength in healthy university	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-18	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-7g48v7	<NULL>	"Are within the age limit ( 18 to 30 ) ;
Not present chronic or acute diseases ;
Who accept participate in the study after signing the Informed Consent and Informed ( WIC)."	"Individuals under 18 and / or greater than 30 years old ;
show any acute or chronic disease;
Do not agree to participate in the collection;
Individuals who fail to answer the research instruments ;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-24pdsj	Influence of the pilates method on the range of motion in postoperative cardiac surgery patients	Recruitment completed	Intervention	2020-07-20	<NULL>	<NULL>	4017	Influence of the pilates method on the range of motion in postoperative cardiac surgery patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Faculdade Nobre	Instituto Nobre de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-24pdsj	<NULL>	The following inclusion criteria were used: Individuals of both genders; aged 18 years or over; undergoing coronary artery bypass grafting with extracorporeal circulation and median sternotomy.	As an exclusion criterion for emergency surgery; patients with hemodynamic or respiratory instability (mean arterial pressure less than 70 mmHg or greater than 110 mmHg, tachycardia above 100 bpm, bradycardia less than 60 bpm, tachypnea greater than 25 ipm and bradypneia less than 12 ipm, drop in oxygen saturation less than 90% ) during the evaluation or application of the method; physical limitation that hindered the assessment; stay in the Intensive Care Unit (ICU) for more than 4 days; readmission to the ICU before hospital discharge; death; individuals with neurological deficit or difficulty in understanding; do not collaborate with the proposed techniques, compromising the assessment of functional capacity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-2vrm3f	Evaluation of the efficacy of Behavioral Psychotherapy in the treatment of Depression in Temporal Lobe Epilepsy	Recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4018	Evaluation of the efficacy of Behavioral Psychotherapy compared to pharmacotherapy in the treatment of Depressive Disorder in Temporal Lobe Epilepsy with Hippocampal Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-17	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vrm3f	<NULL>	Must have a TLE-HS; must be age 18 to 59 years old; must meet the DSM-5 criteria for major depression; must be willing to provide written informed consent; must be compliant, cooperative, reliable, and able to follow instructions, and to visit the clinic on schedule; must have an intellectual level (IQ) of 80 or more; must have a diagnosis of active epilepsy for at least six months and be receiving appropriate neurological treatment; doses of the antiseizure medication should be stable at least eight weeks ago, to start to receive a treatment of this study.	"Have other epileptic syndromes; presence of injury detectable to brain MRI other than that characterizing HS; history of other central nervous system disorder, such as meningitis, tumor, multiple sclerosis or traumatic brain injury; have clinical signs of drug intoxication or any other condition that may cause or predispose to severe impairment of cognition; have diagnosis of psychotic disorder, even though this condition is under remission; have severe psychiatric disorder requiring emergency treatment (e.g. psychosis); have active suicidal or homicidal ideation; have current alcohol or other substance abuse disorders or a history of bipolar depression or any psychotic disorder.
Are pregnant or lactating; are known to be hypersensitive to sertraline; currently taking an antidepressant medication or seeing a therapist regularly; unable to understand or to complete the questionnaires or to participate in treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-8jbwf5	Influence of physical exercise in children with Asthma	Not yet recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4019	Influence of aerobic exercise in children with Asthma diagnosis	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8jbwf5	<NULL>	Children; 8 and 12 years old; diagnosis of intermittent, persistent mild or moderate asthma; pharmacological treatment (corticosteroids or B2-agonists); regularly follow up with a pulmonologist in Campo Grande- MS	Interrupt medical care and/or drug treatment; manifest other acute or chronic pathological conditions; those who miss more than 20% of rehabilitation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7k4yks	The Use of a Bi-Component (Carboxy Cellulose-Polysaccharide B) on the Knee Right After Ligament Reconstruction	Recruitment completed	Intervention	2020-07-20	<NULL>	<NULL>	4020	"The Use of Bi - Component Carboxymethylcellulose-Polysaccharide B in the
Knee Joint After Anterior Cruciate Ligament Reconstruction"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Unifesp/EPM	Unifesp/EPM	https://ensaiosclinicos.gov.br/rg/RBR-7k4yks	<NULL>	Patients between 18 and 45 years old; isolated anterior cruciate ligament injury	Patients with active infectious processes; autoimmune or systemic diseases; previous surgery on the injured knee	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-6w2vtp	Effects of neuromodulation in women with fibromyalgia	Recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4021	Effects of neuromodulation on electroencephalographic activity in fibromyalgia patients and comparison with healthy ones	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal da Paraíba	Programa de Pós-graduação em Neurociência Cognitiva e Comportamento	https://ensaiosclinicos.gov.br/rg/RBR-6w2vtp	<NULL>	Have a diagnosis of fibromyalgia according to the criteria of the American College of Reumathology; Having been diagnosed at least three months ago; Being female; Be in the age group between 35 and 60 years old; Present a pain level above four on the visual analog scale; Sign the Free and Informed Consent Form.	Score below 24 on the Mini Mental State Examination; illiterate; have metallic implants located on the head or cochlear implants or cardiac pacemaker; being pregnant; have a history of seizure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-25jpgt	Influence of Physical Exercise on pain modulation and on psychological, social and behavioral aspects in patients with Chronic Pain of masticatory muscles	Not yet recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4022	Influence of an Individualized Physical Exercise Program on the endogenous pain modulation profile and on the psychosocial and behavioral aspects in patients with Chronic Myofascial Masticatory Pain: a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-25jpgt	<NULL>	Healthy volunteers; of both genders; aging between 18 and 40 years; who do not report the presence of any persistent pain condition in the last 6 months; volunteers diagnosed with myofascial pain according to the DC/TMD; with pain duration greater than or equal to 3 months and with pain report in the last 15 days; primary complaint of pain in the area of the masseter and/or temporal muscles, with the presence of simultaneous pain in the preauricular area being accepted as a secondary complaint	Pregnant women; lactating; high-performance athletes; active individuals by the IPAQ questionnaire; individuals in physical training; individuals with chronic generalized pain, individuals with fibromyalgia, or neurological diseases; high blood pressure and other cardiovascular problems; psychiatric conditions; use of analgesics, antidepressant drugs, membrane stabilizers, benzodiazepines, or any other medication with CNS action; positive answer to one or more questions in the PAR-Q Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-6ck7g2	Expansion of actions to prevent diseases transmitted by the Aedes aegypti mosquito	Recruitment completed	Intervention	2020-07-20	<NULL>	<NULL>	4023	Expansion of innovative interventions and surveillance to prevent and control diseases communicable by Aedes aegypti	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-22	FUNDACAO UNIVERSIDADE ESTADUAL DO CEARA - UECE	FUNDACAO UNIVERSIDADE ESTADUAL DO CEARA - UECE	https://ensaiosclinicos.gov.br/rg/RBR-6ck7g2	<NULL>	Living on the streets included in the study; find themselves in the territories during the interventions; sign the free and informed consent form	Children whose parents did not authorize the participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-3sts3q	Is cementation quality affected by the use of tourniquet in primary total knee arthroplasty?	Recruitment completed	Intervention	2020-07-20	<NULL>	<NULL>	4024	Is cementation quality affected by the use of tourniquet in primary total knee arthroplasty?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Minas Gerais	Hospital Felício Rocho	https://ensaiosclinicos.gov.br/rg/RBR-3sts3q	<NULL>	Patients with knee primary osteoarthritis in which conservative measures have failed. Age  through 30 to 90 years; both genders; non-smoking; with no morbidity obesity (BMI above 40).	secondary osteoarthritis, major deformities (above 20 degrees in the coronal plane); joint stiffness (rom less than 90  degrees); type of implant not associated with the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4mtyr5	Comparison between two different materials for making aesthetic orthodontic bandages in terms of color stability and elastic properties	Data analysis completed	Intervention	2020-07-21	<NULL>	<NULL>	4025	"Aesthetic orthodontic bandages: evaluation of elastic properties and alteration of
color"	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-4mtyr5	<NULL>	Patients with complete permanent dentition (except third molars); between 12 to 20 years old, undergoing orthodontic treatment; good general and oral health; who have not used mouthwash and systemic medication in the last 3 months.	Patients in the transitory phase of dentition, still with the presence of deciduous teeth, presenting poor oral hygiene and consequent oral health, patients with systemic problems and who have used mouthwash and systemic medication for continuous use in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-2zsbgd	Respiratory mechanics parameters of children and adolescents with Cystic Fibrosis: response to the forced expiration technique	Recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4026	Long-term follow-up of the Cystic Fibrosis patient profile	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-23	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-2zsbgd	<NULL>	Children and adolescents between 6 and 15 years old, with confirmed CF diagnosis, and being followed up at the HIJG reference center, clinically stable, who are not hospitalized or with indication for admission at the time of data collection will be included in the research. To participate in the study, parents or guardians must present the free and informed consent form (ICF) and the child or adolescent must consent to participate, by signing the free and informed consent form.	Individuals who demonstrate an inability to properly perform any of the proposed assessment procedures will be excluded, thus preventing the continuity of data collection. Individuals whose data appears to be doubtful will also be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-2g9st7	Follow-up of the clinical performance of bulk-fill restorations in posterior teeth	Recruitment completed	Intervention	2020-07-22	<NULL>	<NULL>	4027	Long-term clinical follow-up on restorations with low-contraction resin composite in posterior teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2g9st7	<NULL>	It was compulsory for the patients to present a pair of class I or II failing restorations (amalgam/composite resin) with cusps partially involved and/or carious lesions on occlusal and/or proximal surfaces. The teeth needed necessarily to be vital as well as the participants were required to be free of edentulous spaces, important occlusal interferences and parafunctional occlusion. The patients were required to be between 18 and 70 years old and to not participate of another clinical study.	It was excluded from the sample those patients with allergy to the materials, cracked teeth, periodontal disease, using chlorexidine at the baseline, tooth sensitivity, antagonist teeth, presenting porcelain restoration as well as a indirect restoration planned to be done. The patients disabled to attend the re-calls as well that present any general health problem existent were not included in the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7tmpdb	Nutritional and Metabolic Profile of Adolescents with Obesity who will undergo Counseling Sessions on Behaviors related to Changes in Lifestyle	Data analysis completed	Intervention	2020-07-22	<NULL>	<NULL>	4028	Nutritional and Metabolic Profile of Adolescents with Obesity submitted to a Behavioral Counseling Program: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tmpdb	<NULL>	Adolescents; both sexes; age between 13 and 18 years; obese	Body mass above 120 kg; Positive PAR-Q; self-reported diseases; electrocardiographic changes at rest; chronic alcohol consumption; previous drug use; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-44h66b	Effect of nasal lavage with Budesonide diluted in large volume for the clinical treatment of patients with Chronic Rhinosinusitis with nasal polyps	Recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4029	Efficacy of adding high volume diluted Budesonide nasal lavage for maximum clinical treatment in patients with Chronic Rhinosinusitis with polyposis: double-blind, randomized, controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-07	Clinica Olfact	Clinica Olfact	https://ensaiosclinicos.gov.br/rg/RBR-44h66b	<NULL>	Patients with a minimum nasal polyp score (SPL) of 5 out of a maximum of 8 for both nostrils (with at least a score of 2 for each nostril); Presence of at least two of the following symptoms before screening: nasal block, obstruction, congestion or rhinorrhea (anterior or posterior); facial pain / pressure; reduction or loss of smell	Patient under 18 years old, or over 55 years old; SNOT-22 with a sum of less than 7; Patients who used drugs or therapies that interfere with the results of this clinical trial, within 2 months before screening: treatment with immunosuppressants; anti-immunoglobulin medications and within two months before screening; Start of allergen immunotherapy in the 3 months prior to the first consultation or a plan to start therapy during the screening period or the randomized treatment period; Patients who have undergone any nasal surgery; Patients using anti-leukotrienes and antihistamines; Asthmatic patients will be excluded if: the forced expiratory volume (FEV1) is 60% of predicted or less; there has been an exacerbation requiring systemic steroidal treatment (oral and / or parenteral) or hospitalization for more than 24 hours for the treatment of asthma, in the 3 months prior to screening; use of a dose greater than 1000 mg of inhaled fluticasone or equivalent; Patients with short life expectancy (less than 6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4yccqm	Comparison between three brands of nasal spray for the treatment of allergic rhinitis	Recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4030	Comparison of three topical budesonide brands in the treatment of allergic rhinitis: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Clinica Olfact	Clinica Olfact	https://ensaiosclinicos.gov.br/rg/RBR-4yccqm	<NULL>	Patients aged between 18 and 55 years who were diagnosed with allergic rhinitis through clinical criteria and positive specific IgE	Patients under the age of 18 and over 55, with rhinitis triggered by other reasons, other than allergic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-49hcnx	Evaluation of the efficacy of multiple stiches as a method of controlling local bleeding in patients using oral anticoagulants: randomized clinical trial	Not yet recruiting	Intervention	2020-07-23	<NULL>	<NULL>	4031	Evaluation of the efficacy of mass suture as a method of local hemostasis in patients using warfarin: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Faculdade de Odontologia da Universidade de São Paulo	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-49hcnx	<NULL>	Volunteers who are being monitored at InCor / HCFMUSP; using oral anticoagulant (warfarin) only as the only medication capable of altering blood clotting and bleeding time; TP / INR (2.0-4.0), accepting to participate in the study; allow clinical examination; present bilateral upper permanent teeth with indication of extraction.	Patients with PT / INR outside the range defined by the study (2-4); patients using drugs such as antiplatelet agents in association with warfarin; with coagulopathies; with liver disease; with thrombocytopathies and thrombocytopenia; toothless upper patients; patients who do not have an indication for extraction; patients who do not accept to participate in the research for any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6f5xbq	Study of treatment discontinuation of chronic myeloid leukemia in the Unified Health System	Not yet recruiting	Intervention	2020-07-24	<NULL>	<NULL>	4032	Efficacy and efficiency of discontinuation of treatment with tyrosine kinase inhibitors in patients with chronic myeloid leukemia treated in the Unified Health System after obtaining a sustained deep molecular response	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2020-08-01	Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas	Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6f5xbq	<NULL>	"Patients with chronic CML; 18 years or older (WHO 2008); treated with TKI for more than 3 years; who have already had a complete cytogenetic response; typical BCR-ABL transcripts (b3a2 and / or b2a2)
Patients with an RM4.5 response (PCR less or equal to 0.032%) sustained for 2 years. The patient must have 4 PCR tests in this period, confirming these results, 2 in the last 6 months.Mandatory use of contraceptive methods for women of childbearing age"	Accelerated or previous blast phase; previous bone marrow transplant; resistance-related BCR-ABL1 mutations; BCR-ABL1 transcripts not measurable by quantitative PCR (unknown initial transcripts; atypical transcripts, such as p190 and others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4jbw4s	Use of Botulinum Toxin for Treatment of Idiopathic Rhinitis	Data analysis completed	Intervention	2020-07-23	<NULL>	<NULL>	4033	Use of Botulinum Toxin Type A for Treatment of Idiopathic Rhinitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jbw4s	<NULL>	Criteria for inclusion in the study: Patients older than 18 years who signed the informed consent form and understood the explanation of the study, carried out by the researcher himself. Patients of both sexes, without distinction of race. Patients diagnosed for idiopathic rhinitis for at least one year, ie patients in whom the other etiologies of rhinitis (allergic rhinitis, non-allergic, drug, hormonal, drug and occupational eosinophilic rhinitis) were excluded from the clinical history , physical examination, nasal cytology examination with eosinophils below 2%, and immediate hypersensitivity skin test for negative inhalants.	Exclusion criteria in the study: Patients with other nasal anatomical abnormalities, such as nasosinusal polyposis or obstructive nasal septum deviation. Patients with acute or chronic rhinosinusitis. Patients with severe systemic diseases, glaucoma or prostatic hypertrophy that may be aggravated by anticholinergic therapy. Patients with immediate hypersensitivity skin test for positive inhalants, nasal cytological examination with eosinophilia greater than 2%.Patients who received rhinitis medications prior to the immediate inhalant hypersensitivity skin test. Patients pregnant or likely to be pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-3jm5y2	Control of urinary loss in men undergoing prostate surgery	Recruitment completed	Intervention	2020-07-24	<NULL>	<NULL>	4034	Effectiveness of integrative and complementary practices associated with pelvic muscle training to control urinary incontinence after radical prostatectomy: randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2019-04-12	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3jm5y2	<NULL>	Preserved locomotor, visual, auditory and swallowing capacity; Have a preserved cognitive function, verified by means of a six-item cognitive impairment test; Present urinary incontinence with the need to use at least one or more absorbents daily; Have a loss greater than one gram assessed using the Pad Test; Have removed the delayed bladder catheter within 10 to 15 days	Do not respond to three attempts at contact made by the researcher; Need for readmission; Be in chemotherapy or radiotherapy treatment; Presence of rectum urethral fistula; Presence of urinary incontinence before the surgical procedure; Urinary tract infection (UTI), with urine culture test showing multi-resistant bacteria and more than one cycle of antibiotic therapy; Infection, inflammation or injury to the ear; Allergy to metal or micropore; Not having financial conditions and availability to be at the place of the study; Use of other complementary therapies up to three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-3fthf8	Clinical trial evaluating the safety, neutralizing capacity and the lowest effective dose for antivenom treatment of multiple Africanized bees stings Apis mellifera	Recruitment completed	Intervention	2020-07-26	<NULL>	<NULL>	4035	Clinical trial phase I/II to evaluate the safety, the neutralizing capacity and the lowest effective dose of antivenom for the treatment of multiple africanized honey bees stings Apis mellifera- APIS Study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Medicina de Botucatu	Benedito Barraviera	https://ensaiosclinicos.gov.br/rg/RBR-3fthf8	<NULL>	Be aged over 18 and under 60 years of both sexes; having a diagnosis of crash with bees Apis; have the consent of the patient or family to receive antivenom.	Have had frequent contact with products of horse; have had previous adverse reaction to receiving the antivenom; to be pregnant; be with chronic disease, including congenital and acquired immunodeficiencies; introduce diseases that the combined use contraindication antihistamines, corticosteroids and potent analgesics, including allergic reaction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-463byn	Effect of rapid maxillary expansion on the quality of life of children with obstructive sleep apnea and residual snoring.	Recruitment completed	Intervention	2020-07-26	<NULL>	<NULL>	4036	Effect of rapid maxillary expansion on the quality of life of children with sleep apnea.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-463byn	<NULL>	Healthy volunteers; both genders; age from 5 to 12 years; they were submitted to adenotonsillectomy; snoring more than 5x a week and maxillary atresia.	Cardiac and neuromuscular diseases; craniofacial malformations or chromosomal syndromes; hypertrophy of adenoid and / or lingual tonsil tissue after the surgical procedure with rhinopharynx or oropharynx obstruction above 50%; loss of teeth, dental caries and periodontal disease; patients using neurological drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7nj9w4	Acute effects of photobiomodulation on respiratory variables and functional capacity in smokers and ex-smokers	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4037	Acute effects of photobiomodulation on respiratory variables and functional capacity in smokers and ex-smokers: randomized clinical trial, triple-blind and controlled placebo	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-14	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7nj9w4	<NULL>	For study 1 volunteers aged over 18 years will be included; smokers aged 1-10 years and smokers aged 11-20 years. For study 2 volunteers aged over 18 were included; ex-smokers for a period of at least 12 months. All volunteers must be clinically stable; do not show dyspnea symptoms on small and medium efforts.	"Alcoholic volunteers who have a cardiac pacemaker implant, coexisting neurological disease and have presented
any lung disease diagnosed, or use of corticosteroids in the last 4 weeks. Volunteers who practice
regular physical exercise, defined as participation in pulmonary rehabilitation programs or structured physical training (3 times per
week) in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8hmb2r	Studying the progression and the consequences of the new Coronavirus in Brazil	Not yet recruiting	Observational	2020-07-27	<NULL>	<NULL>	4038	Multicenter study of the natural history of the new Coronavirus SARS-CoV-2 in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-03	Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)	Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)	https://ensaiosclinicos.gov.br/rg/RBR-8hmb2r	<NULL>	"Age equal to or greater than 18 years;
Patients with fever and/or respiratory symptoms within 7 days;
Contacts of patients with a flu-like syndrome"	"Patients who are unable to participate in study visits.
Patients with severe mental disorders or those from whom the collection of information due to communication disorders or lack of fluency in Portuguese or another language understood by the attending physician is impossible."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8s56by	Effect of musical stimulation associated with Physiotherapy on the movement of sedentary elderly	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4039	Effect of Rhythmic Auditory Stimulation associated with Physiotherapy on the functional mobility of sedentary elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Camila Maria Mendes Nascimento	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8s56by	<NULL>	"Patients aged 60 years or older; sedentary;
with the ability to move independently; lack of medical contraindications for physical exercise; ability to understand instructions and active participation in tasks, considering the scores of the Mini Mental State Examination (MMSE) corresponding to their schooling; visual acuity confirming through the Snellen Signal Scale; hearing acuity verified through the whisper test"	Patients with neurological diseases; orthopedic, rheumatic and  or vascular pathology, with moderate or severe functional restriction in one or both lower limbs;history of fracture in the last year; hypertension and or uncontrolled heart disease; limiting visual and or auditory compromises for the execution of the protocol; amputee, prosthesis and lower limb orthosis users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6hnqcv	Parkinson&apos;s Disease and Physiotherapy: Analysis of the outcome of interventions with land based and water based physical activities - FISIOPARK	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4040	Parkinson&apos;s Disease and Physiotherapy: Analysis of the outcome of interventions with land based and water based physical activities - FISIOPARK	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6hnqcv	<NULL>	Age over 40 years. Both sexes. Clinical diagnosis of idiopathic Parkinson&apos;s disease. Stages 1 to 4 on the Hoehn and Yahr scale. Clinical certificate for physical activity and to attend a heated pool.	Do not walk, whether or not related to PD. To have another disease that may interfere with physical assessments, such as changes in balance of vestibular origin. Sensory, visual or auditory deficits, which prevents from following verbal and visual instructions. Contraindications to use a heated pool, such as fever, incontinence, severe change in blood pressure, open wound. Changes in Levodopa-based medication intake parameters during the study period. Do not agree with the Informed Consent Form. Absence in more than 10% of the intervention. Absence in evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-5s8fy4	Evaluation of the effects of Occlusal Splints and Hypnosis in the treatment of bruxism: A randomized controlled trial	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4041	Electromyography and analysis of quality of life in patients with Bruxism before and after treatment with Occlusal Splints, Hypnosis and Restoration of Canine Guidance - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-5s8fy4	<NULL>	elderly patients, presenting reports of waking up with muscle fatigue and / or pain in the TMJ area, with tooth wear and / or edentulous line in the cheek mucosa, reports of noise (teeth grinding) at night evidenced by a partner, being orthognathic, without missing teeth and as few restorations as possible, from a pre-existing database	underage patients, with dental problems with occlusal instability, prognosis and compensation, alcohol, patients with removable prostheses, large amounts of indirect restorations, use of bite plates, neurological or psychiatric disorders, who use drugs that act on the central nervous system, as antidepressant inhibitors of serotonin reuptake, diseases with muscle and / or motor impairment, cognitive impairments and use of illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4tg72t	The use of vitamin C in the prevention of central venous catheter obstruction in children	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4042	The use of intermittent Ascorbic Acid in the prevention of central venous catheter obstruction in pediatrics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4tg72t	<NULL>	Children between 28 days and 13 years 11 months and 29 days will be included in the study, using a single or double lumen central venous catheter, with the consent of the parents and/or guardians by signing the Free and Informed Consent Term - TCLE added to the Free and Informed Consent Term and that are not accompanied by serum bilirubin dosage	Will be excluded from the study: Carriers of nephrological diseases, clotting disorders and/or hemochromatosis; research subjects with parents under 18 years of age; research subjects whose guardians do not consent to or withdraw from the CLT; research subjects whose do not consent to or withdraw from the CLT; children with bilirubin dosage; newborns under 28 days of age; fully implanted catheter carriers; entry of medicines incompatible with ascorbic acid (etomidate, propofol, tipental, amikacin, vancomycin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8f837n	Gel versus oral estrogen for endometrial preparation in freeze embryo transfer	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4043	Transdermal versus oral estrogen for endometrial preparation in freeze embryo transfer	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-04-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Projeto ALFA - Aliança de laboratórios de fertilização assistida S.A.	https://ensaiosclinicos.gov.br/rg/RBR-8f837n	<NULL>	"Women in the menacme with or older than 21 and with or younger than 38 years, when treated with their own eggs or women with or oldr than 21 and with or younger than 50 years when donor eggs or donor embryo.
One ou more fifth day (D5) or sixth day (D6) frozen blastocysts.
Body mass index (BMI) with or above 18 and with or lower than 35 Kg/m2."	"Endocrine or metabolic abnormalities. 
Serum progesterone concentrations higher than 1 ng / mL, on the day the study started, between the 2nd and 3rd day of the menstrual cycle.
Endometrial thickness higher then 5 mm at the beginning of the study, between the 2nd and 3rd day of the menstrual cycle.
Tumors: ovaries, breasts, adrenal, pituitary or hypothalamus
History of thrombosis or thrombophilia.
Alteration of renal or liver function.
Endometrial anatomical changes.
Hypersensitivity to the active substance or any of the excipients.
History of gastroplasty."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-9mh6p6	To evaluate the effect of pelvic floor muscle training with the &quot;Knack&quot; technique in women with stress urinary incontinence - Randomized Study	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4044	Compare pelvic floor muscle training with “Knack” contraction	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9mh6p6	<NULL>	Women with 18 years old and under 85 years old;diagnosis with stress urinary incontinence; referred for evaluation and treatment at the Urinary Dysfunctions Clinic Urology Discipline - UNIFESP;who agree to participate in the study and sign the free consent form and enlightened.	Women diagnosed with overactive bladder;pregnant woman;neurological disease;with severe cognitive impairment;psychiatric diagnoses;urethral vesicle fistula;stage III prolapse;renal and bladder stones;urethral cysts and diverticula;bladder cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-32rp22	Effect of therapeutic laser on the lips fatigue	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4045	"Effect of low-level laser on the 
electromyographic fatigue of the orbicularis oris muscle"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Centro Universitário Metodista Izabela Hendrix	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-32rp22	<NULL>	"Age between 18 and 60 years; sign the
Informed Consent Form"	"Craniofacial anomaly or disease with neuromuscular involvement; use of myorelaxing and/or anti-inflammatory drugs; 
photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the
application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8z4mhq	Use of açaí and counseling in the treatment of tinnitus	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4046	Chronic tinnitus: analysis of oxidative metabolism, single counseling session and açaí extract as treatment	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8z4mhq	<NULL>	Age from 18 years; complaint of chronic tinnitus of at least six months; normal hearing or sensorineural hearing loss from degree to moderate	Neurological diseases; middle ear changes; hearing aid users; illiterate; coagulopaths	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-5ysj54	BCG vaccine use to prevent COVID-19 in health care workers	Not yet recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4047	BCG vaccine as preventive measure against COVID-19 in health care workers	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-07-15	Universidade Federal do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5ysj54	<NULL>	Individuals aged above 18 years old, male or female, not infected with SARS-CoV-2 who exercise professional activities in the Health Units of the study; Agreement to participate in the study by signing the informed consent form	Professionals with a history of infection confirmed by SARS-CoV-2 or who have already been diagnosed with COVID-19 prior to the study; Individuals who have not performed confirmatory tests for COVID-19; Pregnancy or breast-feeding; Non-permanence in activities in the Health Units after 6 months of enrollment in the study; Individuals with primary or acquired immunodeficiency; Individuals with malignant neoplasms; Patients on high-dose corticosteroids (equivalent to a prednisone dose of 20 mg / day or more) for more than two weeks; Patients using other immunosuppressive therapies (antineoplastic chemotherapy, radiation therapy, among others); Individuals with autoimmune diseases;  Dermatological disorders at the vaccine site or generalized; Individuals under treatment for active tuberculosis; Individuals with report of fever (axillary temperature&gt; 38 ° C in the last 48h)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-65z3qy	Psychoeducation through APP for bipolar patients	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4048	Psychoeducational intervention adjunctive to conventional treatment in bipolar patients	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-65z3qy	<NULL>	to be a patient at the AHC-UEL psychiatry clinic; be between 18 and 65 years old; have a telephone with internet connection available; being diagnosed with BD; understand instructions on using the app.	a) cognitive deficit that does not allow the understanding of the free and informed consent term and the understanding of instructions for use of the app; b) unstable or hospitalized patients; c) problems or inability to operate a smartphone touch screen.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8vny3v	Combined use of body movements with laser light for the stimulation of nerves and muscles on the face	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4049	Different Kinesiotherapies associated with Biophotonics for Neuro-facial muscular Reprograming	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	University of São Paulo, São Carlos Physics Institute, Department of Optics and Biophotonics	University of São Paulo, São Carlos Physics Institute, Department of Optics and Biophotonics	https://ensaiosclinicos.gov.br/rg/RBR-8vny3v	<NULL>	Healthy females; ages between 35 and 55 years; no history of systemic diseases such as hypertension, diabetes or heart diseases	Presence of uncontrolled systemic diseases; pregnant women; breast feeding women; presence of oral tumors; presence of temporomandibular joint disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7xpmy5	Safety and tolerance in the use of Shock Wave Therapy in people with upper limb lymphedema after breast cancer treatment	Not yet recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4050	Safety and tolerance of the use of Shockwave Therapy in Lymphedema secondary to the treatment of Breast Cancer	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2020-08-01	Patricia Lima Ventura	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xpmy5	<NULL>	Women over 18; Women with lymphedema secondary to unilateral breast cancer surgery with an axillary approach (considered lymphedema when there is a difference in perimetry bigger or equal 2.00 cm in at least one point on the affected upper limb in relation to the contralateral one);Those who have undergone complex physical therapy (CFT) in the last year and have controlled lymphedema (with no changes in the last 30 days);Those who agree to participate in the research and sign the Informed Consent Form.	Those with local or remote recurrence;Women with bilateral breast cancer;Those undergoing chemotherapy or radiation therapy;Women with a postoperative period less than six months after the axillary approach; Presence of dermal changes (local signs and symptoms such as hyperemia, hyperthermia, hyperpigmentation, pustules and other skin changes); Report of autoimmune diseases (dermatomyositis, nephropathy, lupus erythematosus, morphea, psoriasis, pemphigus vulgaris, scleroderma); Report of osteomioarticular disease in a member homolateral to the surgery; Women with amputation of a limb; Be illiterate or have difficulty reading and interpreting text;Cognitive and psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7zs8b5	Association of transcranial direct current stimulation and neurofeedback in memory and cerebral arterial flow in university students	Recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4051	Association of transcranial direct current stimulation and neurofeedback in declarative memory and cerebral arterial flow in young university students - randomized, double-blind, placebo-controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade São Leopoldo Mandic	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7zs8b5	<NULL>	Healthy volunteers; both genders; age between 18 to 30 years	volunteers who have a metallic implant in the head region; have a history of epilepsy or seizures; having psychiatric disorders; history of neurological trauma; making use of centrally acting medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-4wr8mz	Evaluation of the effect of deep water running for the treatment of  back pain	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4052	Evaluation of the effect of deep water running for the treatment of back pain	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2014-11-27	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wr8mz	<NULL>	Patients diagnosed with low back pain participated in the study; comprised between the last rib and the gluteal fold; mechanical in character; lasting more than 3 months on most days; with pain assessed by the visual analogue pain scale (VAS) between 3 to 8 cm, and who agreed to participate in the study and signed the free and informed consent form.	"Patients with the following items were excluded from the study:

Fibromyalgia;
Contraindication to the use of non-hormonal anti-inflammatory drugs (NSAIDs)
Pregnancy;
Litigation;
Obesity (BMI&gt; 30);
Secondary causes of low back pain; as spondyloarthropathies; infections; neoplasms; fractures;
Previous spine surgery;
Complete sciatica (irradiated to lower limb below the knee);
Uncontrolled arterial hypertension;
History of coronary insufficiency or history of cardiac revascularization; history of syncopes or arrhythmias induced by physical exercise;
Decompensated diabetes mellitus;
Serious psychiatric illnesses;
History of regular physical exercise (at least 30 minutes twice a week) in the last 3 months;
Hip and / or knee arthroplasty; and any other condition that makes it impossible for the patient to walk and
Dermatological diseases that contraindicate the use of a swimming pool."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-4snqcy	Knowing the whitening therapy: influence of different teeth on the color change and tooth sensitivity	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4053	Knowing a whitening therapy: influence of the dental group on the diffusion of the whitening gel and tooth sensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-4snqcy	<NULL>	Patients who wish to have teeth whitening; patients with healthy, vital 13, 23, 33 and 43 teeth; patients with no carious or non-carious lesion; patients who do not use orthodontic appliances; patients who have never done bleaching; patients with good systemic conditions; patients with healthy oral soft tissues; non-smoking patients	Patients with indirect restorations in the upper and lower anterior region; patients who have a history of adverse reaction to peroxide; patients who use opioids or drugs that influence the neuro-sensory response; patients who have a pacemaker; patients with tooth stains (tetracycline, trauma, fluorosis and unknown etiology); patients with neurological diseases; patients with chronic or acute diseases; patients with exposed dental tissue; patients with dental sensitivity or with a history of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-3m4gbs	Effect of the use of desensitizing gel on the final bleaching and tooth sensitivity results - Controlled, randomized, double-blinded clinical trial	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4054	Effect of the use of Desensitizing Agents on the effectiveness of Bleaching and Dental sensitivity - Controlled, randomized, double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Universidade Estadual do Oeste do Paraná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-3m4gbs	<NULL>	Age between 18 and 25 years; good oral and general health; absence of gingivitis, periodontitis, dental mobility and diabetes; all teeth between the first right upper premolar and the left first maxillary premolar should be present and free of caries and restorations; the maxillary central incisors should be A3 or more saturated.	"Patients who have had a previous dental bleaching procedure; Pregnant and lactating women; Patients who have teeth with severe internal discoloration (resulting from
stained with tetracycline, fluorosis or endodontic treatment) Patients with potentially sensitive teeth such as gingival recession, dentin exposure and poor enamel formation Patients who report sensitivity existing at the time of anamnesis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5gqtbv	Analysis of strength gain in the elderly after the application of resistance training protocols with the use of resistance with free weight and elastic resistance	Recruitment completed	Intervention	2020-07-28	<NULL>	<NULL>	4055	Analysis of strength gain in the elderly after the application of resistance training protocols with the use of different types of resistance: randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5gqtbv	<NULL>	Elderly men and women, aged between 60 and 75 years old, able to practice physical activities and proposed evaluations, availability to participate in activities, absence of medical contraindications to exercises, without any type of orthopedic lesion of the lower limbs, without previous experience in the resistance training or not having practiced it in the last 6 months.	The elderly will be excluded from the study if they have any physical problems and / or osteomioarticular impairments that can be aggravated by the knee extension and flexion movement or who are absent for 3 days consecutive to the training protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-7nky44	Novel Coronavirus infection among health workers	Recruiting	Observational	2020-07-28	<NULL>	<NULL>	4056	Frequency of Novel Coronavirus Disease in health professionals	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7nky44	<NULL>	All professionals who work at the institution and had been tested for COVID-19 by the occupational health ssector	Non applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-2x4hqm	Use of new technologies for the treatment of vaginal sequelae caused by radiotherapy.	Not yet recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4057	Use of non-ablative radiofrequency and intravaginal CO2 laser in the treatment of genitourinary syndrome following cervical carcinoma radiotherapy: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa do Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2x4hqm	<NULL>	Women over 18 years old, up to 50 years old, treated with external radiotherapy in the last 5 years, with genitourinary complaints, without residual tumor lesions and who accept to participate in the study, being informed about the procedures to be performed	Metastatic disease, tumor recurrence, previous treatment of genitourinary symptoms in the last month, presence of genital infection at the beginning of treatment, and women with collagenosis or HIV (Human Immunodeficiency Virus).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-4fzby4	Evaluation of the incision of the layer that covers the testis and reconstruction using a vaginal tunica flap in acute Testicular torsion	Recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4058	Evaluation of the incision of the tunica albuginea and reconstruction using a vaginal tunica flap in acute Testicular torsion	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Santa Casa de São Paulo	Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fzby4	<NULL>	Patients diagnosed with acute testicular torsion	"Bilateral testicular torsion

Testicular torsion in a patient with a single testis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5j2w34	Use of the walking diary after Cardiac Surgery	Data analysis completed	Intervention	2020-07-28	<NULL>	<NULL>	4059	Walking diary in the Cardiac Rehabilitation Phase 1	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Hospital Santa Izabel	Hospital Santa Izabel	https://ensaiosclinicos.gov.br/rg/RBR-5j2w34	<NULL>	Individuals in pre operative of elective cardiac surgery of myocardial revascularization and / or valve surgery; with age equal to or greater than 18 years; of both sexes.	Those with difficulty understanding the procedures performed in the research; that present motor impairment that makes it impossible to perform gait without assistance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-39jh9h	Efficiency of Strengthening pelvic floor muscles in reducing Urinary Urgency symptoms in women	Recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4060	Effectiveness of Training of pelvic floor muscles in reducing symptoms of Overactive Bladder in women - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	UNICAMP- Universidade Estadual de Campinas	Pontificia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-39jh9h	<NULL>	Female gender; age between 18 and 80 years; presenting an urgency symptom assessed through the questionnaire ICIQ OAB; have had the urgency symptom for more than 3 months; ave voluntary contraction of the pelvic floor muscles during inspection; sufficient literacy to fill out the necessary forms and volunteer to sign the consent form.	Pregnancy or intent to become pregnant during the study period; postpartum period (up to 3 months postpartum); women who have never had sexual intercourse with vaginal penetration; women who have had physiotherapy in the last year to treat the symptoms of overactive bladder; women with neurological, metabolic disorders (diabetes associated with neuropathy), or other pathology affecting the functioning of the lower urinary tract; women with suspected other bladder dysfunctions (symptoms of dysuria, suprapubic pain and / or fever, hematuria, vulvar vaginal pain); women with recurrent urinary tract infection; prolapse beyond the hymen; use of medications to control symptoms related to bladder dysfunction within 4 weeks prior to initiation of treatment; previous surgeries involving pelvic floor structures or for the intervention of symptoms of urinary incontinence in the last 6 months; cognitive disorder that compromises the individual&apos;s participation at any stage of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5dn5zd	Effect of weight training, walking and combination of weight training with walking on blood pressure, heart rate and arterial function in patients with stroke sequelae.	Recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4061	Acute effects of resistance, aerobic and concurrent exercises on blood pressure, cardiac autonomic control and arterial function in stroke survivors patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO	UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO	https://ensaiosclinicos.gov.br/rg/RBR-5dn5zd	<NULL>	Right or left hemiparesis, with at least six months of the occurrence of stroke; be able to walk without supervision for home walking; enrolled in a neuro-motor rehabilitation program; score above 36 on the Berg balance scale; minimum score of 50 on the Fulg-Meyer scales; signature of the written informed consent form.	"Smoking; history of drug or alcohol abuse; using beta-blockers, neuroleptics or medications that alter the threshold excitement of the neuronal membrane; hormone replacement therapy; head trauma; metallic prosthetic device in the skull; evidence of secondary hypertension; diagnosed with metabolic, liver, cardiac, oncological, psychiatric, neurological pathologies; body mass index &lt;25 or&gt; 35 kg / m2.
g) Estimated glomerular filtration rate &lt;60 mL/min;
h) Acute or chronic hepatic disease with transaminases &gt;3x upper reference value;
i) Patients with clinical evidence of coronary disease with a history of angina or tests
compatible with myocardial ischemia;
j) Previous history of acute myocardial infarction and/or myocardial
revascularization;
k) Clinical signs of heart failure, symptomatic cardiac arrhythmia or clinically
significant valve disease;
l) Patients with a history of drug or alcohol abuse in the last 10 years;
m) Patients with a history of cancer in the last five years;
n) History of neurological or psychiatric disease (e.g. epilepsy);
o) History of cranial trauma at any age or existence of a metal prosthetic device or
other metal particle in the skull."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-7k79kd	Effect of betaine supplementation on the athlete&apos;s ability to perform multiple repetitions on the bench press	Data analysis completed	Intervention	2020-07-28	<NULL>	<NULL>	4062	Effect of betaine supplementation on athletes&apos; physical capacity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-12-27	CAPES	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7k79kd	<NULL>	Men; Healthy; age between 18 and 30 years; strength training practitioners; no history of use of nutritional supplementation; no history of injury.	Perform training sessions 24 hours before the experimental protocol, present with late-onset muscle pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-93shn8	Total number of children irritated after surgery because of using Midazolam and Clonidine drugs by oral anesthesia before heart surgery	Recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4063	Prevalence of postoperative agitation due to the use of pre-anesthetics Midazolam and oral clonidine in pediatric cardiac surgeries	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Centro Universitário Cesmac - CESMAC	Centro Universitário Cesmac - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-93shn8	<NULL>	Both genders; age between 1 and 12 years; undergoing surgery.	other pre-anesthetics; diagnosed with disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6dwmkx	Effects of cervical exercises in individuals with temporomandibular disorders	Recruiting	Intervention	2020-07-29	<NULL>	<NULL>	4064	Effects of a control neck exercise program in individuals with temporomandibular disorders: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-15	Universidade Estadual de Campinas	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-6dwmkx	<NULL>	All volunteers must: be between 18 and 55 years old; diagnosis of muscle TMD according to RDC / TMD (Ia and Ib); bilateral TMJ dysfunction; have pain and / or tiredness in the masticatory muscles during functional activities for more than 3 months and; present Body Mass Index (BMI) between 18 and 25 kg / m2. The volunteers should present moderate pain intensity in the chewing muscles during chewing, being represented by a value greater than or equal to 4 cm according to VAS.	Women who have dental failure, open bite, crossbite, full or partial dentures, neuromuscular systemic diseases, history of trauma to the face and / or TMJ, joint dislocation, are undergoing orthodontic and / or drug treatment that affects the musculoskeletal system. in pregnancy, and / or who have a whiplash, previous surgery on the cervical spine, and a diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-78dh5d	Comparison between skin closure with single and intradermal points on the knee prosthesis	Data analysis completed	Intervention	2020-07-29	<NULL>	<NULL>	4065	Comparative analysis between single and intradermal skin cloruse in total knee arthroplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Hospital Universitario Ciencias Medicas	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-78dh5d	<NULL>	Patients with primary or secondary gonarthrosis; with indication of total knee arthroplasty; aged 45 to 85 years; both sexes.	Patients with a previous history of knee surgery; with inflammatory diseases of the joints; smokers, i.e. at least 1 cigarette a day; alcoholics with consumption equal to or greater than 15 doses per week for men and 10 doses per week for women; with hypoalbuminemia, i.e. albumin level below 3.5 mg per dl and anemia with hemoglobin less than 10 mg per dl.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-3g5f9f	Educational intervention by cell phone to increase informed choices at childbirth, in the context of the Covid-19 pandemic.	Not yet recruiting	Intervention	2020-07-29	<NULL>	<NULL>	4066	Communication intervention to improve informed choice at childbirth: a randomized controlled trial using digital technology in the context of the Covid-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-28	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g5f9f	<NULL>	1) Be a registered user at PiniOn app; 2) Identify theirselves as women; 3) Be aged between 18 and 49 years; 3) Being pregnant or having biological children of any age or intending to have biological children in the future.	Women without children and with no intention of becoming a mother in the future will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-9rrqhk	Effect of an intervention program in the implementation of healthy school canteens	Other	Intervention	2018-07-11	<NULL>	<NULL>	4067	Effect of an intervention program in the implementation of healthy school canteens: a randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Rio Grande do Sul	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9rrqhk	<NULL>	Primary and Secondary Schools of the public and private network of the “Território da Cidadania do Noroeste Colonial”, in RS, that own sales structure in canteen format at the school	Schools with exclusive care for children with special needs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6phs67	Effects of hippotherapy on the elderly	Recruiting	Observational	2020-07-30	<NULL>	<NULL>	4068	Effects of hippotherapy on the cardiovascular, immune, stomatognathic system and postural balance in elderly practitioners: longitudinal study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo FORP/USP	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-6phs67	<NULL>	Individuals of both genders and age between 60 and 79 years, without compromising gait and who are beginning the practice of hippotherapy with the project.	Epilepsy, hypertension (uncontrolled), acute heart disease, spinal instability, severe cervical spine disorder, shoulder or hip dislocation, scoliosis evolving by 30 degrees or more, decubitus ulcers in the pelvic region or in the lower limbs, uncontrollable fear who did not complete the expected number of sessions and / or had more than two consecutive absences during the sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5fjcmr	Evaluation of Gynecological and Dermatological Acceptability of Health Products using the product at home.	Not yet recruiting	Observational	2020-07-30	<NULL>	<NULL>	4069	Evaluation of Gynecological and Dermatological Acceptability of Health Products under Normal Conditions of Use	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-24	Makelab Consultoria Eireli	Makelab Consultoria Eireli	https://ensaiosclinicos.gov.br/rg/RBR-5fjcmr	<NULL>	Women; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the region; Occasional user of category products	"Skin marks in the experimental area that interfere in the evaluation of possible
reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, heart or liver transplantation;
 Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus,
atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study .; Any condition not mentioned above that, in the investigator&apos;s opinion, may
compromise the evaluation of the study.
Note: the participants included are instructed not to change their diet, routine
exercises and contraceptive method. Also, not to use products of the same category
of the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-78v9hx	Influence of a Virtual Reality treatment on Postural Balance of patients with Stroke	Recruiting	Intervention	2019-10-16	<NULL>	<NULL>	4070	Influence of a Virtual Reality treatment protocol on Postural Balance of individuals with Stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-78v9hx	<NULL>	First episode of unilateral stroke (ischemic or hemorrhagic); postural balance deficits (Berg Balance Scale score -BBS) more than 45); injury time more than 6 months; age between 20 and 75 years; at maximum level 2 of the modified Ashworth Scale to assess the spasticity of the paretic lower limb; good cognitive status based on the Mini-Mental State Examination (MMSE); ability to walk without personal assistance indoors (Functional Ambulation Category -FAC) scores equal to or more than 3; clinically stable, with no history of epilepsy or seizures in the last 6 months; not having signs of unilateral neglect or sensory or global aphasia as assessed by National Institute Health Stroke Scale -NIHSS); no uncorrected hearing and/or visual impairments; not participating in a balance treatment protocol; ability to understand and obey simple motor commands.	Presenting other clinical conditions affecting balance; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-7w5zhr	Frailty and negative consequences in adults hospitalized for COVID-19	Recruiting	Observational	2020-07-30	<NULL>	<NULL>	4071	Frailty and adverse outcomes in adults hospitalized for COVID-19	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-7w5zhr	<NULL>	We will include consecutive patients hospitalized for COVID-19, between March and July 2020. Patients are screened for eligbility at admission according to the following criteria: age greater than or equal to 50 years; suspected (signs and symptoms suggestive of the disease without confirmatory tests), probable (signs and symptoms suggestive of the disease with compatible tomographic image) or confirmed COVID-19 (agent detected by laboratory test), as per WHO guidelines; informed consent for participation in the study.	We will exclude patients for whom the diagnosis of COVID-19 is discarded during follow-up until the end of hospitalization  (absence of a compatible tomographic image, negative virus detection tests, and alternative diagnosis more likely).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5bzbvs	Analysis of 2 drug protocol of dexamethasone in the removal of wisdom tooth	Data analysis completed	Intervention	2020-07-30	<NULL>	<NULL>	4072	Analysis of 2 preemptive periods of dexamethasone in the removal of the third molars. A controlled, randomized, split-mouth, and triple-blind clinical study	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Estudal Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5bzbvs	<NULL>	Young adult patient (18-30 years); Third bilateral molars (upper and lower) with similar positions and angulations evaluated in panoramic; Need for osteotomy and odontostomy for exodontia.	Smolker; Decompensated Metabolic Diseases; Use of medicines that interfere with healing; Periodontal Disease; Inflammation or pathologies associated with third molars.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-6cvt9p	Randomized Clinical Trial on Hydrofiber with Extra Silver in the Treatment of a Patient with Venous Ulcers	Recruiting	Intervention	2020-07-30	<NULL>	<NULL>	4073	Randomized comparative study between Aquacel and Safgel in the treatment of a patient with Venous Ulcers	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Guarulhos	Universidade Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-6cvt9p	<NULL>	between 18 and 80 years;diagnosis of one or more venous ulcers on any lower limb, being venous; with palpable pulses;recent ulcers with a minimum of six weeks on the lower limb; understanding of the guidelines made by the researcher, to ensure continuity of treatment.	"the therapeutic regimen of use for venous ulcers in the lower limb; arterial and \ or mixed injuries; with circular lesions in the lower limbs, with distal pulses not palpable;
pregnant patients and infants; diabetic patients; with a history of using illegal substances and \ or; with a history of mental disorder (identified in the medical record by a doctor)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5bxtgx	Electric current applied to women with painful menstrual cramps: A randomized clinical trial with economic evaluation.	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	4074	Transcutaneous electrical nerve stimulation for primary dysmenorrhea: A randomized clinical trial with economic evaluation.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-15	Universidade Federal de São Carlos	São Paulo Research Foundation	https://ensaiosclinicos.gov.br/rg/RBR-5bxtgx	<NULL>	Nulligravid women over 18 years old; women with a regular menstrual cycle; and women with PD: with a report of pain equal to or greater than four points on the Numerical Rating Scale in the last three months.	Pregnant women or postpartum women; women with intrauterine device (IUD); women with lesions in the area where the electrodes will be placed; women with neurological or cardiac diseases; and women with diagnose gynecological disorders such as endometriosis, adenomyosis and uterine fibroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5db955	Effect of  exercise training on clinical markers ,quality of life and mental health in women with polycystic ovary syndrome	Recruitment completed	Intervention	2020-07-27	<NULL>	<NULL>	4075	Brazilian Study on Polycystic Ovary Syndrome (PCOS)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Departamento de Educação Física	Departamento de Toco-Ginecologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5db955	<NULL>	Age between 18 to 40 years; (2). Body mass index greater than or equal to 18.5 kg / m² and less than 40 kg / m² (3). Diagnosis of PCOS; (4); without physical exercise in the last six months or sedentary;	(1). Pregnant women; (2). They present androgen-secreting tumors, Cushing&apos;s syndrome, congenital adrenal hyperplasia, hyperprolactinemia (greater than 40ng / ml) and thyroid dysfunction; and (3). Diabetes mellituS; (4).one positive response on the PAR-Q or any other contraindications for physical activity, as determined by a medical history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-8bgcs3	Early physical exercise in ischemic stroke patients undergoing thrombolytic treatment	Recruiting	Intervention	2020-07-31	<NULL>	<NULL>	4076	Very early mobilization after thrombolysis in a stroke unit in Salvador - Ba: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-8bgcs3	<NULL>	&gt; 18 years old, thrombolyzed, hemodynamically stable, oxygen saturation&gt; 92% and temperature &lt;38.5º, preserved cognitive (being able to respond to the examiner&apos;s command during the tests (Item 1 of the NIHSS) and application of resources), and who have Rankin previously referred (Rankin ? 2).	Patients with clinical and / or radiological deterioration within the first hour of admission to the stroke unit or direct admission to intensive care, documented pathological treatment, indication for immediate surgery, other serious or unstable medical illness, coronary disease, no response to voice will be excluded , Systolic blood pressure less than 110 mm Hg or greater than 220 mm Hg, oxygen saturation less than 92% with oxygen supplementation, resting heart rate less than 40 beats per minute or greater than 110 beats per minute, temperature greater than 38 ° C, or that has other interventions that prevent the protocol from being carried out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-37ry9f	Influence of physiotherapy and Ziclague ® in the standing posture and gait in children with cerebral palsy	Recruiting	Intervention	2020-07-31	<NULL>	<NULL>	4077	Influence of kinesiotherapy to gain orthostasis and gait in cerebral palsy children with spasticity associated with the use of Ziclague ®	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Tiradentes	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-37ry9f	<NULL>	Patients with Spastic Cerebral Palsy; Diparetic or tetraparetic Commitment; Classified by the Modified Ashworth Scale between One and Three grades; Aged between One and Twelve years old.	Children with Hypotension, the medication Ziclague is contraindicated (according to the package insert) to people with blood pressure lower than 100 / 60mmHg; Heart disease, avoid applying medication that has not yet been tested in children with Cerebral Palsy who are cardiac patients; Excessive irritability, hyperactivity, involuntary movements, other syndromes or neurological disorders in addition to cerebral palsy, these kinetic disorders will interfere in the performance of the exercises proposed in the treatment of the study, which may generate false results; That have not been subjected to the application of botulinum toxin, the application of botulinum toxin will promote relaxation by decreasing acetylcholine that directly interferes with the pharmacodynamics of the Ziclague® that presents a therapeutic target to the type L calcium channels and releases the action of acetylcholine in the muscles; Surgery on the spine or hip in the last 6 months, these surgeries in this period contraindicate or induce an unviable physical condition for trunk activities or orthostatic activities that make the protocol proposed by the present project unfeasible; Participants who do not adhere correctly to the treatment, ensuring participation in the treatment sessions and following the guidelines prescribed by the researchers; Who have any health problems that interfere with their motor condition; Who develop an allergic reaction to the drug Ziclague®, after starting treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-76r3t7	Effect of Vocal Therapy associated with Electrical Stimulation in women with Voice Changes	Data analysis completed	Intervention	2020-08-03	<NULL>	<NULL>	4078	Effect of Electrostimulation associated with Semi-occluded Vocal Tract Exercises in patients with Behavioral Dysphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-76r3t7	<NULL>	Women; aged 18 to 60; behavioral dysphonia	Patients with organic changes of congenital origin; diagnosis of head and neck cancer; history of previous surgery in the head and neck region with impact on the voice; patients with neurological diseases; history of speech therapy in the last six months; history of electrical stimulation in the last six months; thyroid changes; severe heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-9fkttf	Vaccination against Influenza in Acute Coronary Syndromes in Brazil Evaluation	Recruiting	Intervention	2019-08-13	<NULL>	<NULL>	4079	Vaccination against Influenza in acute coronary syndromes in Brazil Evaluation trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-07-08	Hospital Alemão Oswaldo Cruz	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-9fkttf	<NULL>	Volunteers with STEMI as defined by chest pain suggestive for myocardial ischemia for at least 30 minutes before hospital admission, time from onset of symptoms of less than 24 hours, and an ECG with new ST-segment elevation in two or more contiguous leads of more or equal to 0.2 mV in leads V2-V3 and/or more or equal0.1 mV in other leads or a probable new-onset left bundle branch block or patients with a diagnosis of NSTEMI defined by a combination of: onset of symptoms such as central chest pain or an agravated angina pectoris, with or without an ECG change with ST-segment lowering or an inverted T-wave, and at least two values with levels of troponin-T or troponin-I above the established margin of an AMI or unstable angina defined as new or recently progressive angina symptoms; male or female subjects &gt; 18 years; written informed consent.	Influenza vaccination during the current influenza season or the subject anticipating to be vaccinated during the current influenza season; indication for influenza vaccination for some indication other than myocardial infarction; severe allergy to eggs or previous allergic reaction to influence vaccine; suspicion of febrile illness or acute, ongoing infection; hypersensitivity to the active substances or ingredients of FluQadri® or against any residues, such as eggs (ovalbumin or chicken proteins), neomycin, formaldehyde and octoxinol; subjects with endogenic or iatrogenic immunosuppression that may result in reduced immunization response; inability to provide informed consent; age below 18 years.; previous randomization in other similar trial (testing other types of vaccination which may interfere on clinical outcomes of the VIBE trial).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8g9897	Evaluation of new models of intraocular lenses for cataract surgery.	Not yet recruiting	Intervention	2020-08-03	<NULL>	<NULL>	4080	Evaluation of the efficacy and safety of new models of intraocular lenses for cataract surgery.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Associação Evangélica Beneficente de Minas Gerais	Hospital Público Prefeito Osvaldo Rezende Franco	https://ensaiosclinicos.gov.br/rg/RBR-8g9897	<NULL>	"Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular, or a combination) who was considered amenable to treatment by
cataract extraction using the intracapsular facectomy method. Adult patients 21 years of age or older. Patients eligible for primary intraocular lens implantation. Patients willing and able to perform clinical and complementary tests for follow-up for a minimum period of 1 year after cataract surgery. Patients who require intraocular lens implantation powers ranging from 10 to 30 diopters. Patients with visual potential of 20/40 or better in the eye indicated for intraocular lens implantation. Patients with corneal cylinders to correct less than 1 diopter."	Patients with the best corrected visual acuity less than or equal to 20/200 in the contralateral eye. Patients with any pathology of the anterior segment in which the procedure of intracapsular facectomy with primary IOL implantation is contraindicated (examples: keratoconus, corneal dystrophies or scars, anterior uveitis). Patients with corneal inflammation or edema, included and not limited to: keratitis, keratoconjunctivitis and keratouveitis. Patients with uncontrolled glaucoma or glaucoma under treatment. Patients with a history of retinal detachment. Patients with diabetic retinopathy (proliferative or non-proliferative). Patients with congenital, metabolic, traumatic or complicated cataracts. Patients with marked microphthalmia or aniridia. Patients who have had previous proposed eye surgery. Patients who have already received another IOL in the contralateral eye. Irregular corneal astigmatism. Amblyopia. Clinically significant changes in the retinal pigment epithelium / macula. Neovascularization of the iris, camerular and retinal angles. Severe recurrent inflammation of the anterior or posterior segment of unknown etiology. Optical atrophy. Patients with immunodeficiency (infectious, neoplastic or medicated). Patients on chronic use of systemic steroids or immunosuppressive drugs. Patients participating in another clinical trial simultaneously. Patients with strong dependence on intermediate vision, night vision or specific occupational requirements (examples: commercial pilots and professional drivers).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-7dsxsv	Software to evaluate clinical, epidemiological data and chest computed tomography to predict which patients with COVID-19 will develop a severe form of the disease.	Recruiting	Observational	2020-08-04	<NULL>	<NULL>	4081	Machine Learning model to predict the prognosis and severity by computed tomography and clinical-epidemiological correlation in COVID-19 patients.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Diagnósticos da América Sociedade Anônima (DASA)	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-7dsxsv	<NULL>	Signs and symptoms of acute respiratory syndrome. Positive epidemiological history for COVID-19, which may include recent contact (last 14 days) with a confirmed or suspected case, recent trip (last 14 days) to a high-incidence location, or presentation of symptoms after the start of the community transmission phase of SARS-CoV-2 (after 20/03/2020) when the date of hospitalization. Have performed, when symptomatic, a chest computed tomography.	Presence of neoplastic (primary or metastatic) lung lesions, manifested as nodules, masses, consolidations, septal thickening (lymphatic carcinomatosis) or pleural thickening. Chest computed tomography with the presence of movement, acquisition or reconstruction artifacts that make it impossible to apply the segmentation algorithms. Computed tomography exams with low quality pulmonary segmentation, or cut slice thickness greater than 3.0 mm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-3zg5z6	Using a Platform That Vibrates to Decrease Body Fat of Women	Recruiting	Intervention	2020-08-04	<NULL>	<NULL>	4082	Efficacy of using the vibrating platform to reduce body fat in women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Sociedade de ensino superior de Serra Talhada - SESST - EPP	Sociedade de ensino superior de Serra Talhada - SESST - EPP	https://ensaiosclinicos.gov.br/rg/RBR-3zg5z6	<NULL>	Being female; aged 18 to 30 years; body mass index (BMI) high than 18; not engaging in regular exercise; not undergoing any type of weight-loss treatment; whether drug, dietary or aesthetic; have signed the informed consent form	Those who did not attend two consecutive sessions; with uncontrolled systemic arterial hypertension; uncontrolled diabetes; circulatory and hormonal disorders; infections; cardiac or renal pathologies; existence of osteoarticular trauma; using diuretics or corticosteroids; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-75bsvk	Video modeling technique in dental care for autistic children	Not yet recruiting	Intervention	2020-08-04	<NULL>	<NULL>	4083	Efficacy of the video modeling technique as a facilitator of dental care in children with Autistic Spectrum Disorder: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-08	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-75bsvk	<NULL>	Children of both sexes; between 4 and 12 years old at the time of the study; diagnosis within the autism spectrum disorder, verbal and non-verbal, which meet the diagnostic criteria established by the American Psychiatric Association	Autistic children with other associated syndromes, such as Down syndrome, Rett syndrome, Tuberous sclerosis; Autistic children with hearing and visual impairments; Autistic children with associated intellectual disabilities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8tw8y5	A double-blind controlled study of acute effects of Elastic Bandage on myofascial pain	Recruitment completed	Intervention	2020-08-04	<NULL>	<NULL>	4084	A double-blind, randomized, controlled, trial of acute effects of Kinesio Taping on Temporomandibular Disorders Myogenic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8tw8y5	<NULL>	Volunters with diagnosis of myogenic TMD using the Research Diagnostic Criteria for Temporomandibular Disorders for 6 months or more; aged between 18 and 60 years of which only subjects up to 57 years old were found for both groups	Recent or old facial trauma, undergone treatment for Myogenic Temporomandibular Dysfunction in the last six months; use analgesic and or anti-inflammatory drugs in the last six months; using occlusal plaque; being under orthodontic treatment; presence of central or peripheral neurological disorders; having a diagnosis of systemic disease and a history of surgery and or tumors or trauma in the head and or neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-35734p	Treatment of severe COVID-19 with angiotensin-(1-7)	Recruiting	Intervention	2020-08-05	<NULL>	<NULL>	4085	Randomized clinical trial phase I/II for the use of angiotensin-(1-7) in the treatment of severe infection by Sara-CoV-2	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-08-05	Angitec	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-35734p	<NULL>	Age: less than 17 and less or equal to 81 years; Admission to the Intensive Care Unit with severe pneumonia criteria (clinical signs of pneumonia + one of the following criteria: respiratory rate greater than 30 irpm; signs of respiratory effort, SatO2 less than 90% in room air); COVID-19 confirmed or highly suspicious (positive contact or suggestive image)	Patients diagnosed with cancer (at any stage); Hemodynamic instability (need for vasopressors); Pregnant women; Immunocompromised patients; Exclusive Palliative Care; Inclusion in any other interventionist study; Heart failure as a predominant cause of acute respiratory failure; decompensated liver cirrhosis; HIV +; Dialysis; Home / long-term oxygen therapy; Idiopathic pulmonary fibrosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-544pfq	Telephone Monitoring of Blood Cancer Patients in outpatient Chemotherapy: proposal for an assistance protocol	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4086	Telephone monitoring of onco-hematological patients undergoing outpatient chemotherapy: proposal for an assistance protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Universidade Federal Fluminense	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-544pfq	<NULL>	Medical diagnosis of Lymphoma that would initiate first-line outpatient chemotherapy treatment regimen: International Disease Code (ICD-10) for Non-Hodgkin&apos;s Lymphoma and its classifications (C82 to C85) and Hodgkin&apos;s Lymphoma and its classifications (C81), absence of previous chemotherapy treatment and who had Karnofsky Perfomance Status (KPS) or Zubrod Scale (ECOG) between 70% to 100% or 0-1 (Appendix A) (90-1), respectively, assessed by the doctor and the nurse at the first consultation turn; patients aged 18 to 64 years and have a fixed or mobile phone.	Presence of cognitive deficit and / or change in physical conditions that make participation in the research and hearing deficit unfeasible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8j2r7d	Study on Resisted Exercise in improving Fatigue in Patients with Primary Sjogren&apos;s Syndrome: Blind Randomized Clinical Trial	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4087	Effectiveness of Resisted Exercise in improving Fatigue in Patients with Primary Sjogren&apos;s Syndrome: Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8j2r7d	<NULL>	"Be diagnosed with Sjogren&apos;s syndrome according 
the American-European Consensus criteria, having fatigue complaint, age above 18 years, woman."	Patients with cognitive difficulties, secondary Sjogren&apos;s Syndrome; regular physical activity practitioner or who had been practicing physical activity regularly for up to 8 weeks prior to initiation of the protocol; patients who did not accept the study norms; those with clinical conditions that precluded the practice of exercise program according to previous medical evaluation( such as decompensated diabetes mellitus, decompensated thyroid diseases, cardiorespiratory diseases); systemic diseases such as renal failure, liver failure, anemia and muscle inflammation; use of hypnotic or immunotherapeutic medications such as rituximab; age below 18 years or above 100 years;  men	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8bt3hg	Cognitive assessment and patients with multiple sclerosis and their relationship with performance in virtual tasks	Recruiting	Intervention	2020-08-05	<NULL>	<NULL>	4088	Neuropsychological assessment and patients with multiple sclerosis and their relationship with performance in virtual tasks	<NULL>	1-2, non-randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-06-01	EACH - USP	Associação Brasileira de Esclerose Múltipla	https://ensaiosclinicos.gov.br/rg/RBR-8bt3hg	<NULL>	Patients diagnosed with MS undergoing clinical follow-up at the Brazilian Multiple Sclerosis Association; People from the city of São Paulo who do not have MS.	People with MS and without MS with psychiatric illnesses; visual illnesses; fatigue; muscle deformity or weakness in upper limbs; outbreak in the last 2 months; surgery or chemical neuromuscular blockade in the upper limbs in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8mqt4m	Effects of a multi-component training program on physical fitness and risk of falls in the elderly	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4089	Effects of a multilateral training program on pjysical fitness and parameters related to the risk of falls in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-21	Universidade Federal do Paraná	Gleber Pereira	https://ensaiosclinicos.gov.br/rg/RBR-8mqt4m	<NULL>	Older adults; both genders; able to perform standardized exercises; present a medical certificate proving that they are clinically able to perform physical exercises; accept to participate voluntarily by signing a free and informed consent form	Older adults who participated in less than 70% of sessions; older adults who had some type of injury severe in the last six months prior to the study, which prevented them from performing all scheduled exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6gfsbv	Development of quercetin-based food	Recruitment completed	Intervention	2020-08-06	<NULL>	<NULL>	4090	Quercetin project: formulation development of quercetin-based nutritional supplement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-10	Laboratório Farmacêutico da Marinha	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6gfsbv	<NULL>	The research subjects will be approximately 50 volunteers, all male. They will be preferentially recruited among the soldiers of the Marine Corps, as they are submitted to the practice of high intensity physical activity and to situations of physical and psychological stress. They must not be carriers of chronic diseases, they must be free from inflammatory and / or infectious diseases and they cannot regularly use anabolic drugs and steroids.	People with inflammatory and / or infectious diseases and regularly using medications and anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6jmwc8	Meditation effect on blood pressure of adults with high blood pressure	Data analysis completed	Intervention	2020-08-06	<NULL>	<NULL>	4091	Meditation acute effect on hypertensive adults blood pressure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jmwc8	<NULL>	Hypertensive adults aged between 30 to 50 years of age	Absence in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-97vkx4	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	Not yet recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4092	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-97vkx4	<NULL>	Healthy volunteers; chronic pain; plantar fasciitis; age over 18 years	Neuropathy; skin lesions; degenerative lesions; previous allergy to sodium hyaluronate; allergies to avian proteins; collagen disorders; rheumatoid arthritis; seronegative arthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-564y4n	Evaluation of muscle weakness, function and quality of life after Intensive Care Unit discharge in survivors of COVID-19	Recruiting	Observational	2020-08-06	<NULL>	<NULL>	4093	Investigation of muscle weakness, function and quality of life after Intensive Care Unit discharge in survivors of COVID-19	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-20	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-564y4n	<NULL>	Both sexes; aged 18 years and above; confirmed diagnosis of COVID-19; treatment with invasive mechanical ventilation; survivors during the hospitalization period, and discharge from the ICU.	Primary cause of using invasive mechanical ventilation is not pneumonia caused by COVID-19; not be subjected to invasive mechanical ventilation; death during the ICU stay; inability to understand verbal commands and altered level of consciousness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-56nzq6	Root coverage of multiple gingival recessions treated with a coronary repositioned flap associated with connective tissue graft or collagen matrix graft of porcine origin.	Recruitment completed	Intervention	2020-08-06	<NULL>	<NULL>	4094	Root coverage of multiple recessions treated with coronally advanced flap technique associated with autogenous connective tissue graft or Xenogeneic tissue substitute - experimental and randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-56nzq6	<NULL>	Patients aged between 18 and 60 years; both sexes; bilateral multiple Miller class I and II  recessions associated or not with non-carious cervical lesions.	Smokers; Alterations in the systemic health; Active periodontal disease; Interproximal bone loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-7hs2mv	Effects of multicomponent exercises on the elderly health	Recruiting	Intervention	2020-08-06	<NULL>	<NULL>	4095	Effectiveness of a multicomponent exercise program on older adults&apos; health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Departamento de Educação Física da Universidade Federal do Paraná	Programa de Pós-Graduação em Educação Física- PPGEDF/UFPR	https://ensaiosclinicos.gov.br/rg/RBR-7hs2mv	<NULL>	Will be included in this study men and women aged from 60 years, with independent mobility (without using auxiliary devices), who are able to practice physical activities and who are not regularly participating in a systematic physical exercise program.	Will be excluded from the study, older adults with disabling osteoarticular diseases of the lower limbs; those  who have insufficient cognitive function to understand the tests and exercises; who have undergone orthopedic surgery in the six months preceding the study; and that present some absolute contraindication to physical exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2w7ghc	"Online meditation as an aid in reducing symptoms of Depression, Anxiety and Psychological Stress in Resident Physicians
during COVID-19 pandemic in Brazil"	Recruiting	Intervention	2020-08-07	<NULL>	<NULL>	4096	"Effects of meditation on
symptoms of Depression, Anxiety and Psychological Stress
in resident doctors
during the COVID-19 pandemic in Brazil:
A quasi-experimental study"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-20	Maria do Rosário Toscano von Flach	Maria do Rosário Toscano von Flach	https://ensaiosclinicos.gov.br/rg/RBR-2w7ghc	<NULL>	Medical residents of both sexes, who are attending the first (R1) or second (R2) years of training in any specialty, in any hospital in the city of Salvador will be included in the study	"Not wanting or not being able to answer the questionnaires;
To be or have been known to have a psychiatric disorder;
Abandon meditation training before completing the 12-week program;
Abandon the residency program for any reason, before the 12 weeks foreseen for the development of the program"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-864jjk	Role of genetic variability and susceptibility in occupational exposure to anesthetics	Recruiting	Observational	2020-08-07	<NULL>	<NULL>	4097	Role of polymorphisms, genetic instability, oxidative response, expression and genetic methylation in occupational exposure to anesthetics	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-09-04	Departamento de Anestesiologia	Faculdade de Medicina de Botucatu (FMB)-UNESP	https://ensaiosclinicos.gov.br/rg/RBR-864jjk	<NULL>	Professionals working in the operating room; occupationally exposed to anesthetics; both genders and healthy individuals not exposed to inhaled anesthetics as participants in the control group	Malignant disease carriers; carriers of infectious or inflammatory diseases; those who regularly use alcohol; smokers; users of &quot;illicit drugs&quot;; those who use medication and / or vitamin supplementation; individuals exposed to radiation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2f9k8p	Profile of hospitalized patients with Covid-19 and repercussions of physiotherapy	Recruiting	Observational	2020-08-07	<NULL>	<NULL>	4098	Clinical and epidemiological profile of hospitalized patients with Covid-19 and repercussions of physiotherapeutic performance	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-06-18	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2f9k8p	<NULL>	Suspected inpatients or diagnosed with COVID-19; of both genders; age between 0 and 90 years.	Suspected cases with subsequent examinations that do not meet the criteria established for the diagnosis of COVID-19 or with inconclusive examination; patients who do not present all hospitalization data, discharge correctly registered in electronic medical records.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4vynk5	Effect of the Increase of daily steps in Urinary symptoms and Cardiac function in men aged 50 to 59 years	Data analysis completed	Intervention	2020-08-07	<NULL>	<NULL>	4099	Effect of the Increase of daily steps in Lower urinary tract symptoms, Autonomic cardiac function and Maximum oxygen consupmtion in men aged 50 to 59 years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-27	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4vynk5	<NULL>	men, aged 50 to 59 years, complain of lower urinary tract symptoms with a result greater than or equal to eight in the application of the International Prostate Symptom Score instrument	Tobacco use, conditions that make physical exercise unfeasible, chronic or prostatic diseases, previous history of bladder or prostatic surgery, neurological dysfunction of the bladder, bladder neck or urethral stenosis, as well as lithiasis, carcinoma or bladder polyposis, recurrent UTI, concomitant use or in the month prior to inclusion of any drug or condition affecting urinary function, cardiological and neurological diseases and use of any drug or substance that had action in the autonomic nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2fw8kg	Initial study of the effects of cannabidiol in patients with generalized anxiety compared to the effects of an anxiolytic (clonazepan)	Not yet recruiting	Intervention	2020-08-07	<NULL>	<NULL>	4100	Pilot study of the effects of Cannabidiol in patients with Generalized Anxiety Disorder compared to the effects of Clonazepan	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-08-21	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-2fw8kg	<NULL>	Diagnosis of Generalized Anxiety Disorder (from SCID-5-CV); both sexes, education above eight years; age between 18 and 60 years; total score greater than or equal to 20 on the Hamilton Rating Scale for Anxiety (HAMA); total score greater than or equal to the Global Clinical Impression - Severity scale (CGI-S); total score greater than or equal to 17 on the Hamilton Depression Rating Scale (HAMD17).	Presence of general medical condition; history of neurological disease (except headache); current or past diagnosis of psychoactive substance abuse or use in the past three months; psychotic conditions of any nature according to SCID-5_CV throughout life; other psychiatric diagnoses in addition to generalized anxiety disorder in the last 6 months (except for past remitted depression, social phobia and / or specific phobias); suicide risk (including suicide attempt in the last 1 year); history of previous drug treatment for generalized anxiety disorder; hx of allergy or idiosyncratic reactions to Cannabis sativa derivatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-7d7ngw	Early prone position in patients on spontaneous ventilation	Recruiting	Intervention	2020-08-07	<NULL>	<NULL>	4101	Early prone position in spontaneous ventilation patients with respiratory failure secondary to COVID-19: randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2020-07-15	Hospital Geral Roberto Santos	Hospital Geral Ernesto Simões Filho	https://ensaiosclinicos.gov.br/rg/RBR-7d7ngw	<NULL>	Patients will be included in surveys over the age of 18; are available hemodynamically; with arterial oxygen saturation greater than or equal to 94%; temperature below 38.5 degrees; Respiratory rate below 30 breaths per minute; who are on spontaneous ventilation to the environment or using oxygen support.	Patients who do not have a confirmed diagnosis of COVID-19 will be excluded; patients with severe acute arrhythmias; with a history of hemodynamic instability or recent cardiorespiratory arrest; Recent cardiothoracic surgery or unstable chest; Polytrauma with unstabilized fractures; Pregnant women; Recent abdominal surgery or stoma formation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-35mxys	Lack of a chiral pharmacokinetic interaction between venlafaxine and nifedipine in healthy subjects phenotyped as normal CYP2D6, CYP2C19 and CYP3A metabolizers.	Data analysis completed	Intervention	2020-08-07	<NULL>	<NULL>	4102	Lack of a chiral pharmacokinetic interaction between venlafaxine and nifedipine in healthy subjects phenotyped as normal CYP2D6, CYP2C19 and CYP3A metabolizers.	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2010-01-30	CAPES	CNPQ	https://ensaiosclinicos.gov.br/rg/RBR-35mxys	<NULL>	Healthy volunteers; male; adults (23-33 years old); self-reported as white, body mass index (BMI) of less than 25 kg/m2; biochemical and hematological parameters within healthy range;	Smoking volunteers; volunteer using drugs; volunteers with biochemical and hematological parameters registered abnormality;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2k66ft	Randomized,  study to evaluate early prone position in patients with COVID-19	Not yet recruiting	Intervention	2020-08-10	<NULL>	<NULL>	4103	Randomized, open, controlled study to evaluate early prone position in awake patients on spontaneous ventilation with mild to moderate respiratory distress syndrome secondary to COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-20	Rodrigo S Biondi	Rodrigo S Biondi	https://ensaiosclinicos.gov.br/rg/RBR-2k66ft	<NULL>	Patients with COVID-19 confirmed by RT-PCR or strong suspicion, defined as both typical clinical picture and typical chest CT scan. Presence of bilateral infiltrate on chest tomography and one of the following two: Patient with SpO2 below 94% in room air or Need for O2 by nasal catheter above 4L per min to maintain SpO2 above 94%	"Denial of the patient or physician or assistant team to participate in the study. Evident signs of ventilatory fatigue (RF greater than 30irpm, PaCO2 greater than 45mmHg, with pH less than 7.35 and use of evident accessory musculature with indication of imminent intubation
# Need more than 5 EPAP and 5 IPAP in NIV. Hemodynamic instability (need for Noradrenaline above 0.3mcg per kg per min). Respiratory failure (IRPA) with estimated intubation in the next 6 hours. Cervical, sternotomy or facial surgery less than 15 days ago. Impossibility of collecting arterial blood gases. Evidence or strong suspicion of a cause of IRPA other than COVID pneumonia. Disorientation. Pregnant women with a pregnant abdomen. Have participated in the study previously. Exclusive palliative care. Any clinical impossibility of prone position such as instability or fracture of the spine, pelvis or femur; Massive hemoptysis in need of surgical intervention; Anterior thoracic drain with air leak; Presence of pacemaker installed less than 2 days ago"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-9y32yy	Acute and chronic cardiovascular and respiratory changes in COVID-19 hospitalized patients and the effect of physical rehabilitation supervised by telecommunication	Not yet recruiting	Intervention	2020-05-24	<NULL>	<NULL>	4104	Acute and chronic cardiorespiratory changes in COVID-19 hospitalized patients: role of endothelial function and cardiovascular health in clinical-functional outcomes and effect of physical telerehabilitation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Estadual Paulista - UNESP	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-9y32yy	<NULL>	At least 100 adult patients (aged over 18 years), of both sexes, diagnosed with COVID19 in molecular biology exam, admitted (intensive care unit or infirmary) to referral hospitals in the state of São Paulo will be evaluated. According to the phases of the study, and for inclusion, volunteers must: PHASE 1 (to assess endothelial function and functional capacity): present hemodynamic and respiratory stability; not having the need for emergency medical care; not to be at imminent risk of death. The inability to express consent to participate in the study will not be considered an exclusion criterion, however, in this case, the informed consent form must be signed by the legal guardian. PHASES 2 and 3: not being pregnant; not be lactating. Patients with decompensated cardiovascular and/or pulmonary disease, and/or pacemaker users, and/or who have absolute contraindications for physical exercise (acute myocardial infarction; unstabilized unstabilized angina; uncontrolled cardiac arrhythmias with repercussion will not be included) hemodynamic; symptomatic severe aortic stenosis; uncontrolled symptomatic heart failure; acute pulmonary embolism or pulmonary infarction; acute myocarditis or pericarditis; acute aortic dissection).	Exclusion criteria will include: important hemodynamic and/or electrocardiographic changes during the cardiopulmonary stress test; need for hospital readmission; failure to meet 60% of scheduled interventions. Even if exclusion occurs during the phases, these patients will still be followed up by telephone, up to 12 months, to assess out-of-hospital outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4wzd8p	Treatment of Neck Metastases from Thyroid Cancer by Ultrasound Guided Ablation	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	4105	"Ultrasound guided percutaneous thermal ablation
of cervical metastases from thyroid carcinoma"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto do Câncer do Estado de São Paulo - ICESP	Fundação Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4wzd8p	<NULL>	18 years of age or older; Patients with fine needle aspiration biopsy (FNAb)-proven metastatic cervical lymph nodes at levels I, II, III, IV, V, VI or VII from thyroid carcinoma (well differentiated, papillary - PTC or medullary) who underwent total thyroidectomy and subsequent radioiodine therapy, in case of PTC; Patients considered high surgical risk candidate or patients who are informed about the ablation therapy and prefers it instead surgery; Patients with metastatic cervical lymph nodes over 0.8 cm diameter and under 4.0 cm diameter; no more than 6 metachronous cervical nodal metastases; Cervical recurrences in previously lateral neck dissection patients for well differentiated papillary or medullary thyroid carcinoma over 0.8 cm diameter.	Age under 18 years; Uncorrectable coagulopathy; Inconclusive or benign cytologic specimens; Pregnancy or breast-feeding; Anaplastic or poor-differentiated thyroid carcinoma; Partial thyroidectomy; Cervical tumors not considered to surgery (invading vessels, nerves, larynx or trachea); Serious medical illness, including any of the following: uncontrolled angina, myocardial infarction, cerebrovascular event within 6 months prior to the baseline visit, uncontrolled congestive heart failure; Participation in other studies that could affect the primary endpoint	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6ckggn	Adapted Functional Training and Pilates Method in Individuals with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2019-11-21	<NULL>	<NULL>	4106	The Impact of Adapted Functional Training and the Solo Pilates Method on Motor and Non-Motor Symptoms of Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6ckggn	<NULL>	Inclusion criteria are defined as, participants with a clinical diagnosis of PD following the UK brain bank criteria (HUGHES et al., 1992); both sexes; aged 50 years or over; with stable doses at; at least two weeks; no change in medication; without any functional training or solo pilates for at least three months.	Exclusion criteria were, participants who did not reach the MMSE cut-off point (considering educational level) (BERTOLUCCI et al., 1994); classified in stage 5 PD (HOEHN; YAHR, 1967); who performed practice of any physical exercises to avoid confusion bias in the intervention; who did not complete all stages of the study; were not present in 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6h9wqy	The Effect of a Respiratory Physiotherapy Procedure on Microcephaly	Data analysis completed	Intervention	2020-08-11	<NULL>	<NULL>	4107	Impact of a Respiratory Physiotherapy Protocol on Patients with Mirocephaly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Centro Universitário Braz Cubas	Centro Universitário Braz Cubas	https://ensaiosclinicos.gov.br/rg/RBR-6h9wqy	<NULL>	Confirmed diagnosis of Microcephaly; Both sexes, aged up to six years; Whose parents and / or guardians have signed an informed consent form (ICF); Follow up at Centro Universitário Brazcubas; Patients with at least 75% attendance.	Whose parents and / or guardians have not signed the Free and Informed Consent Form (ICF); Tracheostomized patients and / or dependent on invasive mechanical ventilation; Patients with less than 75% frequency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8wwk3n	Follow-up of Molar and Incisive Teeth With Yellowish or Brown Smears of Hipomineralization After Receiving Preventive Treatments	Recruitment completed	Intervention	2017-01-18	<NULL>	<NULL>	4108	Longitudinal Evaluation of Affected Teeth by Molar Incisor Hipomineralization Submitted to Different Preventive Treatments - Randomized Clinical Study of 3 arms	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-20	Faculdade de Odontologia de Araraquara - FOAr/UNESP	Faculdade de Odontologia de Araraquara - FOAr/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8wwk3n	<NULL>	Natural children of Araraquara city / São Paulo / Brazil; Be between 6 and 14 years old; Have good systemic health; Have at least one molar and / or incisor affected with demarcated yellow or brown opacities of Molar Incisor Hipomineralization; Be in regular treatment in the Pediatric Clinic of Araraquara Dental School - FOAr / UNESP; Accept to participate in the study by child signing the assent term and guardian signing the Term of Consent Free and Clarified.	Patients with other developmental defects or enamel changes; Patients who use fixed or mobile orthodontic appliances; Patients with demarcated opacities of Molar Incisor hipomineralization that present enamel fractures and / or caries lesions on affected teeth;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-9vm3sr	Equipment for puncture of children: clinical study	Recruitment completed	Intervention	2020-08-11	<NULL>	<NULL>	4109	Technologies for peripheral intravenous catheterization of hospitalized children: randomized crossover controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-13	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9vm3sr	<NULL>	Children from 0 to 17 years 11 months and 29 days; subject to peripheral intravenous puncturing; continuous intravenous therapy; hemodynamically stable; have at least one risk factor for failure of the procedure; to be or to be admitted to the unit with a minimum stay of 48 hours;	Not signing the Informed Consent Form; not being punctured with both transillumination equipment; refusing to participate in the research;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6cb3pg	Knowing whitening therapy in its application, color change and decreased tooth sensitivity	Recruitment completed	Intervention	2020-08-11	<NULL>	<NULL>	4110	"Knowing the Whitening Therapy: effect of the place of application of the gel on the alteration
chromatography and postoperative sensitivity"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-6cb3pg	<NULL>	Patients who wish to have teeth whitening; patients with healthy, vital 13 and 23 teeth; patients with no carious or non-carious lesion; patients who do not use orthodontic appliances; patients who have never done bleaching; patients with good systemic conditions; patients with healthy oral soft tissues; non-smoking patients	Patients with indirect restorations in the upper and lower anterior region; patients who have a history of adverse reaction to peroxide; patients who use opioids or drugs that influence the neuro-sensory response; patients who have a pacemaker; patients with tooth stains (tetracycline, trauma, fluorosis and unknown etiology); patients with neurological diseases; patients with chronic or acute diseases; patients with exposed dental tissue; patients with dental sensitivity or with a history of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-4vy54v	On-Line Collectives in Mental Health: Transdisciplinary Action for Groups Vulnerable to COVID-19	Not yet recruiting	Intervention	2020-08-11	<NULL>	<NULL>	4111	On-Line Collectives in Mental Health: Transdisciplinary Action for Groups Vulnerable to COVID-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	FAPERGS	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4vy54v	<NULL>	Elderly people aged 60 or over or health professionals between 20 and 59 years old; score greater than or equal to 7 on the Self-Reporting Questionnaire.	elderly and health professionals who do not have access to the internet; individuals with indicators of neurological pathologies or with psychiatric symptoms or with risk of suicide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-85fm7b	Caiu na rede Project Fell: adolescent health interventions on the triple frontier	Terminated	Intervention	2020-08-11	<NULL>	<NULL>	4112	Caiu na rede: strengthening intersectoral interventions in adolescent health care on the triple frontier	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Fundação Parque Tecnológico de Itaipu	Fundação Parque Tecnológico de Itaipu	https://ensaiosclinicos.gov.br/rg/RBR-85fm7b	<NULL>	"Adolescents between 14 and 17 years old.
Adolescents enrolled in the institutions participating in the project."	"Adolescents under 14 and over 17 years of age.
Adolescents without ties to participating institutions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-55kvhv	Effect of furniture adjustments on posture, pain and discomfort	Recruitment completed	Intervention	2020-08-12	<NULL>	<NULL>	4113	Effectiveness of an ergonomic office  intervention on posture, pain and discomfort - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-55kvhv	<NULL>	Inclusion criteria were that workers were between 18 and 60 years old, who had an office work routine (at least 4h / day on 5 days a week), who agreed to participate in the study by signing the consent form.	Exclusion criteria for the study were: BMI greater than 30 kg / m², not having a fixed job or sharing the job with another worker, using a laptop, using two monitors and having surgery in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-9qrsf8	Comparison of the Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4114	Comparison of analgesia of Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block: a randomized multicenter study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP	IAMSPE - Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qrsf8	<NULL>	Patients over 18 years of age undergoing unilateral pulmonary surgery under thoracotomy or thoracoscopy approach.	Patients who refuse participation. Severe puncture site infection or deformity. Coagulation disorder (INR greater than 1.4 or use of anticoagulant medications and platelet count less than 100,000 / mm3). Body mass index greater than 35kg / m2. Renal impairment (creatinine clearance less than 30 ml/min). Failure to operate the PCA system or to sign the informed consent form. Patients undergoing bilateral surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-57z7gz	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4115	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients: clinical, randomized, double-blind, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Luciana Mara Meireles Aguiar Pereira	Luciana Mara Meireles Aguiar Pereira	https://ensaiosclinicos.gov.br/rg/RBR-57z7gz	<NULL>	Patients over 18 years old admitted to the intensive care unit; both genders, on mechanical ventilation; who walked at least 10 meters before hospitalization.	Neuromuscular diseases; lower limb amputation; pregnancy; body mass index above 40 kg / m2; presence of external fixator or metal implants in lower limbs; open ulcers or skin lesions; pacemaker; rhabdomyolysis or creatinophosphokinase dosage above 4000 ui; cardiorespiratory arrest; spinal cord injury, stroke or head trauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-4yyktr	The effect of Laser on the clinical treatment of secondary Lymphedema of legs	Recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4116	The effect of Photobiomodulation on the clinical treatment of secondary Lymphedema of lower limbs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-09	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4yyktr	<NULL>	"Patients with unilateral or bilateral lymphedema of the lower limbs due to secondary causes; Over 18 years of age; Agreement in participating in the study; Mowlem I and II or according to the International Society of Lymphology stage
I and II"	Patients with uncontrolled renal, cardiac or pulmonary disorders; Uncontrolled hypertensive patients; Patients with polyneuropathies; Pregnant women, and infants; Patient with active infection and open wounds; Patients who abandon treatment, and or attendance below 70%; Patients with primary lymphedema; Patients who have received previous treatment at least 3 months ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8pqmd4	Use of pressure within the lung in cardiac surgery	Recruitment completed	Intervention	2020-08-12	<NULL>	<NULL>	4117	Use of final expiratory pressure in heart surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-11	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-8pqmd4	<NULL>	Individuals undergoing elective cardiac surgery with cardiopulmonary bypass; both sexes; age over 50 years; accept to participate in the study	Individuals who have undergone previous cardiac surgery; neuromuscular disease; pneumopathy; previous pneumectomy; chronic obstructive pulmonary disease; obese individuals; hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6z82zb	Electrical Currents Associated With Carboxytherapy In Cellulite: Double-Blind Randomized Controlled Trials	Not yet recruiting	Intervention	2019-12-18	<NULL>	<NULL>	4118	Pain management associated with carboxytherapy application in patients with cellulite	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Universidade Federal de São Carlos- UFSCar	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-6z82zb	<NULL>	Women; aged between 18 and 49 years, with body mass indexes (BMIs)  in between 18.5 of 39.9 kg/m; menstruation cycle; with no prior experience with carboxythrapy and with the presence of Grade I or light and II or moderate cellulite in the gluteal region	Pregnant women; breastfeeding women; women with metabolic and autoimmune dysfunctions; women presenting dermatological lesions in the gluteal region; women who underwent surgical procedures in the gluteus; women with a history of epilepsy; presence of malignant or benign tumours; heart disease and/or use of a pacemaker; hypoesthesia or anaesthesia in the gluteal region; women with organ dysfunction who participate in CO2 metabolism and elimination; such as renal failure; diuretic use; chronic pain (over 3 months);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6f65qp	Correction of the anterior cruciate ligament injury with the use of the functional graft clinical and microscopic characteristics of the maintenance of the muscle residue of the flexor tendons.	Recruitment completed	Intervention	2020-08-13	<NULL>	<NULL>	4119	Reconstruction of the anterior cruciate ligament using a functional graft clinical and histological characteristics of the maintenance of the flexor tendon muscle remnant.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-07	Universidade Federal de São PauloUnifesp	Universidade Federal de São PauloUnifesp	https://ensaiosclinicos.gov.br/rg/RBR-6f65qp	<NULL>	patients with previous ACL injury, healthy; both genders; non smokers; age between 18 and 60 years; weight within the range of 15% of the weight considered normal for men and women, taking into account height and physical structure.	Smoking patients were excluded; history of alcohol or drug abuse; diagnoses of voluntary smoking pathologies; history of previous surgeries or angular deformities in the operated limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-52qtts	Stress Urinary Incontinence: Comparison between Pelvic Floor Muscle Training and Pilates Method.	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	4120	Effects of Pelvic Floor Muscle Training (TMAP) or Pilates Method in the treatment of stress urinary incontinence in women: Prospective, Randomized and Controlled Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-52qtts	<NULL>	Women who complain of SUI and answer questions 3 and / or 6 of the ICIQ-SF questionnaire positively, and women who do not have urinary incontinence and who answer question 3 of the ICIQ-SF negatively.	The exclusion criteria established were the presence of neuromuscular diseases, inability to contract MAP (Oxford Scale &lt;1), having already undergone physiotherapeutic treatment for SUI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-7p2xmg	Complete Denture Retained by One Short Implant in resorbed jaws: a prospective study	Recruitment completed	Intervention	2020-08-13	<NULL>	<NULL>	4121	Overdenture retained by a Single Short Implant in atrophic mandibles: a prospective study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Odontologia da Universidade Federal de Goias	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7p2xmg	<NULL>	Present the need to replace or to receive new dentures according to normative criteria and/or own demand (perceived need); Do not have contraindications to the surgical procedure of implant installation (mainly related to uncontrolled systemic diseases, such as diabetes and hypertension); To present reduced bone volume in the mandibular symphysis with a maximum height of 9 mm (base of the chin to the alveolar ridge) for the installation of a short implant without the need for bone grafting procedures; Be able to understand and respond to the questionnaires used in the study.	Unavailability to meet the schedule of return visits; Local conditions that could directly influence the stability and/or retention of the prostheses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8fb7q2	Effects of Mucuna Pruriens Supplementation on muscle gain, strenth and testosterone concentration in resistance trained men	Suspended	Intervention	2020-08-13	<NULL>	<NULL>	4122	Effects of Mucuna Pruriens Supplementation on muscular hypertrophy, strength and free testosterone concentrarion in resistance trained men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Universidade Federal de São Paulo campus Baixada Santista	Universidade Federal de São Paulo campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-8fb7q2	<NULL>	Male individuals who were 20-40 years old and practiced resistance training for at least 3 months non-interuptly.	the participants will be excluded if they take some medication, sterois and supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-5smtym	Obstructive sleep apnea and orthopedic maxillary expansion	Not yet recruiting	Intervention	2020-08-13	<NULL>	<NULL>	4123	Polysomnographic evaluation of adult patients with Obstructive Sleep Apnea (OSAS) undergoing Orthopedic Maxillary Expansion	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5smtym	<NULL>	adults, 21 to 65 years old, diagnosed with OSAS by polysomnography; intolerance to continuous positive airway pressure (CPAP); with maxillary atresia; Mallampati 3 or 4; without palatine or lingual tonsillar hypertrophy	Patients with missing more than one upper molar, patients with dentures or partial or total dental implants; who have periodontal disease with alveolar bone loss; caries or extensive coronary destruction in posterior upper teeth; who do not agree with the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-4pfygr	Clinical study to assess the safety and tolerability of administration, directly into a vein, of human umbilical cord and placental blood plasma (Plasmacord®) in patients with Severe acute respiratory syndrome resulting from Sars-Cov-2 infection (fever, cough headache, muscle aches and difficulty breathing)	Not yet recruiting	Intervention	2020-08-13	<NULL>	<NULL>	4124	Clinical study to evaluate the safety and tolerability of intravenous infusion of plasma from human umbilical cord and placental blood (Plasmacord®) in patients with Severe Acute Respiratory Syndrome resulting from Sars-Cov-2 infection	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-07-27	CRYOPRAXIS - CRIOBIOLOGIA LTDA	CRYOPRAXIS - CRIOBIOLOGIA LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4pfygr	<NULL>	Age over 18 years; both sexes; positive test for COVID-19; indication for transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; absence of therapeutic alternative	Pregnant women; under 18 years old; no indication of transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; existence of therapeutic alternative	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8j9kqy	Evaluation of symptoms, respiratory, pulmonary image and inflammation in patients who have been hospitalized for coronavirus infection in the period of a year, multicentric study (fenix)	Recruiting	Observational	2020-08-13	<NULL>	<NULL>	4125	Evaluation of clinical symptoms, respiratory, radiological and metabolomic function in patients who have been hospitalized for coronavirus infection (covid-19) in the period of a year: multicentric study (fenix)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-06-02	Faculdade de Medicina de Botucatu	Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-8j9kqy	<NULL>	Age over 18 years;presence of characteristic symptoms of the disease in an acute form of COVID-19 with positive test with needed of hospitalization;hypoxemia proved during hospitalization;chest computed tomography scan with pulmonary involvement during hospitalization and signing the informed consent form	Patients with other virus diagnosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-79j38k	The effect of magnesium sulphate on rocuronium action	Recruiting	Intervention	2020-08-14	<NULL>	<NULL>	4126	Influence of magnesium sulphate on rocuronium pharmacodynamics - randomized control trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-79j38k	<NULL>	Elective surgeries under general anesthesia; needing  neuromuscular blocker; ASA 1 and 2	Neuromuscular diseases; BMI higher than 35 or smaller than 18.5 Kg.m2; peripheral temperature smaller than 32 degrees; indicative signs in performing laryngoscopy and tracheal intubation; kidney and liver disease; hydroelectrolytic desorders and base acids; use of drugs that act in JNM; difficulty acessing the ulnar nerve; hypersensitivity to drugs used; gastroesophageal reflux.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-7bc8zp	strong cctive mind Project - strength exercises to improve the cognition of older women	Recruitment completed	Intervention	2019-09-19	<NULL>	<NULL>	4127	Adaptations of cognitive, muscular, functional and sedentary behavior induced by Strength Training with and without blood flow restriction in older women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-03	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7bc8zp	<NULL>	"The eligibility criteria for the evaluation of the subjects will be, women; between 60 and 80 years old; apparently healthy, without osteo-articular problems in the upper and lower limbs, contraindicated for strength exercises;  physically active; no history of previous cardiovascular, neurological or psychiatric diseases, controlled hypertension; no history of traumatic brain injury
with loss of consciousness for more than 30 minutes; non-alcoholic and non-smokers; absence of uncorrected motor, visual and auditory impairment; have completed elementary school education or higher; no Brachial Ankle Index, less than 0.90 and greater than 1.40, which characterizes a sign of peripheral arterial disease; have not participated in strength training for at least 6 months; present value above 24 in the Mini Mental State Examination questionnaire"	The exclusion criteria adopted will be regular non-follow-up in training sessions and any test phase with absence in training exceeding 25 percent of total sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-67y6cz	Virtual Reality in diabetic elderly	Recruiting	Intervention	2019-10-14	<NULL>	<NULL>	4128	Influence of a Virtual Reality protocol on body balance of elderly with Mellitus Diabetes type 2: controlled randomized clinical test	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-67y6cz	<NULL>	Will be included in the study individuals aged between 65 and 79 years; have a clinical diagnosis of type 2 diabetes mellitus according to the criteria of the American Diabetes Association - ADA (GROSS et al., 2002); presenting complaints of altered body balance, defined as imbalance and / or dizziness (BITTAR, BOTTINO, BENTO, 2003); have a higher risk of falls by the Dynamic Gait Index with a score of 19 or less (SHUMWAY-COOK, WOOLACOTT, 1995); do not present cognitive impairment according to education (BRUCKI et al., 2003); have mild or moderate peripheral neuropathy assessed by the Neuropathic Symptom Score - ESN (MOREIRA et al., 2005); have good visual acuity assessed by the Snellen Table (JANUZZI et al., 2014); are not undergoing some kind of body balance rehabilitation or performed it up to six months before the survey.	(1) Individuals undergoing balance rehabilitation currently or in the past six months; (2) clinical diagnosis of carpal tunnel syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-5wqr2j	Pain education and exercise program supported by mobile phone for patients with chronic low back pain	Data analysis completed	Intervention	2020-08-13	<NULL>	<NULL>	4129	Pain education and exercise program supported by mobile technology for patients with chronic low back pain: a pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-27	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5wqr2j	<NULL>	Patients with low back pain as their primary musculoskeletal complaint (pain between the 12th thoracic vertebra to the gluteal fold) for three or more months; with or without irradiation of symptoms to lower limbs; aged 18 and over; both sexes; residents of the of Fortaleza, CE.	Patients with severe hearing or cognitive deficits that would prevent them from answering the questionnaires; those who present complaints of pain in the lumbar region with specific diagnosed origin (fracture, tumor, vertebral stenosis); severe associated systemic or neurological disease; history of spine surgery; in physical therapy treatments for DLC or who do not have a cell phone. Those who use medications with analgesic action were not excluded from the project, however the amount and type of medication used were recorded in the pre and post intervention periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-3nqhfy	Quality of life assessment after dental sensitivity treatment with ozone oil	Data analysis completed	Intervention	2020-08-17	<NULL>	<NULL>	4130	Quality of life assessment after dentin hypersensitivity treatment with ozone oil - triple blind randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	UFVJM	UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-3nqhfy	<NULL>	Patients complaining of dentin hypersensitivity with cold, sweets, acidic foods and brushing, and with clinical diagnosis of dentin hypersensitivity; both sexes; without distinction of color or socioeconomic condition; age between 18 to 60 years; with good general and oral health.	Patients presenting restorations and carious lesions in the exposed dentin of hypersensitive teeth; who used painkillers, anti-inflammatories and antidepressants frequently; and, presence of gingival inflammation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6cvc85	Online Parent Training Platform for complementary treatment of behavioral disorders in Attention Deficit Hyperactivity Disorder	Not yet recruiting	Intervention	2020-08-17	<NULL>	<NULL>	4131	Online Parent Training Platform for complementary treatment of Disruptive Behavior Disorders in Attention Deficit Hyperactivity Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6cvc85	<NULL>	Families whose children have Attention Deficit/Hyperactivity Disorder and/or Oppositional Defiant Disorder; children must have externalizing symptoms such as hyperactivity and/or oppositional behavior; children who are between 6 and 12 years old; male gender	Families whose children have severe psychiatric comorbidities (i.e. psychosis, bipolar affective disorder, severe depression), genetic or neurological; whose intelligence is below the 5th percentile; feminine gender. Families whose primary caregivers have intelligence below the 5th percentile or have been diagnosed with serious psychiatric conditions (i.e. psychoses, bipolar affective disorder, severe depression); and families with severe social adversity in the home context (i.e. domestic violence, physical abuse, extreme poverty, hunger)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-262j28	Endoscopy Removal of Polyps from the Large Intestine and Rectum by the Water Immersion Technique	Data analysis completed	Intervention	2020-08-17	<NULL>	<NULL>	4132	Colorectal Mucosectomy of Adenomas and Serrated Lesions by the Water Immersion Technique (Underwater): A Prospective Clinical Study	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-01-22	Hospital Madre Teresa	Hospital Madre Teresa	https://ensaiosclinicos.gov.br/rg/RBR-262j28	<NULL>	Patients with lesions without endoscopic stigmata of deep submucosal invasion, equal to or greater than 5 mm in length and considered suitable to endoscopic resection. Lesions not previously detected but which were identified during the study&apos;s procedure and fulfilled these criteria were also included.	Exclusion criteria were lesions that showed signs of malignant degeneration or deep submucosal invasion (depression, ulceration, friability, bleeding, induration, Kudo pit pattern V); pedunculated polyps; patients with familial polyposis syndromes; those with contraindications (e.g. coagulation disorders and other comorbidities) for endoscopic resection by any technique and patients who did not agree to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6tnm7d	Nutritional response and clinical complications in patients with enteral tube	Data analysis completed	Intervention	2020-08-18	<NULL>	<NULL>	4133	Enteral nutritional therapy in hospitalized patients: enteral tube usage in post-pyloric and gastric positions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6tnm7d	<NULL>	Adults hospitalized patients with risk for malnutrition	Patients were excluded when transfered to other hospitals or when another route of diet provision was suggested	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-8yn35p	Eye maneuver in modulating the autonomic nervous system in academics: a randomized clinical trial	Recruitment completed	Intervention	2020-08-18	<NULL>	<NULL>	4134	Oculomotor maneuver in autonomic modulation in academics: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8yn35p	<NULL>	The participants were healthy; aged between 18 and 30 years old; regardless of gender; who agreed to conduct the research by signing the informed consent form (ICF).	The individuals who reported psychiatric problems; neurological diseases; glaucoma; constant use of drugs; women in menstrual periods or pregnant women and people who were using contact lenses did not participate in the research; in addition to those who requested to withdraw from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9xhgs6	Evaluation of the effectiveness of calcium hydroxide-based medications in root canal inflammation	Recruitment completed	Intervention	2020-08-18	<NULL>	<NULL>	4135	Monitoring of the Periapical Inflammatory Process before and after the use of different intracanal medications through the levels of pro-inflammatory cytokines, metalloproteinases and their antagonists	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-15	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9xhgs6	<NULL>	"Patients in adulthood;
Need for endodontic treatment;
Permanent teeth with primary endodontic infection;
Unirradicular;
Presence of a single canal and periapical lesion;
Absence of periodontal pockets greater than 4 mm;
No mobility."	"Teeth that can not be insulated with the rubber dam;
With root fracture;
Exposure of the pulp chamber;
Patients who have used antibiotics or antifungals in the last 3 months;
Patients with systemic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-6pf78g	Effect of selfintention practice on eating behaviour, body measures and body image in overweight women	Data analysis completed	Intervention	2020-08-18	<NULL>	<NULL>	4136	The impact of self-intention on food intake, anthropometry and body image of overweight women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6pf78g	<NULL>	Women with BMI &gt; 25Kg/m²; have access on internet; have smartphone with WhatsApp	Be in treatment for weight loss in the last three months, whether by use of medications or diets; have a BMI of less than 25 kg/m²; being in use of hormone replacement therapy; presenting some physical deficiency that prevents the accomplishment of the anthropometric measures; presenting some level of cognitive deficit that prevents the eating record register	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-62q6tf	Effect of amber stone necklace / bracelet with improvement of tooth eruption symptoms, and its benefits against anxiety in dental treatment in children	Recruiting	Intervention	2020-08-18	<NULL>	<NULL>	4137	"Effect of the amber necklace / bracelet on the symptoms of tooth eruption and its
benefits against anxiety in dental treatment in infant patients"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-26	Faculdade de Odontologia da UFRJ	Faculdade de Odontologia da UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-62q6tf	<NULL>	"The inclusion criteria in the sample will be babies between 8 and 36 months of age who have at least one erupting primary dentition tooth (without natal or neonatal teeth) and that the parents are already familiar with the initial symptoms of the tooth eruption;
The inclusion criteria in the sample 2 will be children between 7 and 12 years old who already have a history of anxious profile in dental consultations; showing fear and apprehension during consultations, making dental care difficult and completing the questionnaire have moderate to high anxiety results."	"The exclusion criteria will be children with cognitive impairment (assessed by the pediatrician); history of medical treatment for any systemic disease that may influence the signs and symptoms of teething; current drug treatment, not using drugs for local use; use of teethers that relieve the symptoms of tooth eruption and pacifiers; oral or dental anomalies or deficiencies; and lack of parental consent to participate in the research.
Exclusion criteria in phase 2 will be children with cognitive impairment (assessed by the pediatrician), history of medical treatment for any systemic disease that may influence the signs and symptoms of anxiety, children with hormonal problems related to cortisol or who use corticosteroids for up to 30 days prior to the beginning of the research; current drug treatment, including tranquilizers and anxiolytics, both pharmaceutical and natural; which may interfere with the results of the use of the amber necklace; as well as the lack of consent from parents or children to participate in the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-89xh75	Set of Educational Interventions for self-care and prevention of disabilities in people with leprosy.	Recruitment completed	Intervention	2020-08-18	<NULL>	<NULL>	4138	Educational Intervention Bundle in Self-Care and Disability Prevention in People with Leprosy: Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-08	Universidade Regional do Cariri - URCA	Universidade Regional do Cariri - URCA	https://ensaiosclinicos.gov.br/rg/RBR-89xh75	<NULL>	People aged 18 years or over, leprosy cases in the Paucibacillary classification in the Tuberculoid and Multibacillary form followed at specialized centers or by the FHS that was found in the sixth month of treatment (for multibacillary cases), due to the possibility of accompanying them in these months and with a disability grade of 0 to 1.	People who were not found after three attempts to contact the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-7xytb6	Labor induction with synthetic prostaglandins in obese woman	Recruiting	Intervention	2020-08-19	<NULL>	<NULL>	4139	Labor induction with synthetic prostaglandins in obese woman: A randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Universidade Federal da Paraiba	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-7xytb6	<NULL>	Nulliparous or multiparous pregnant obese women; 37 weeks of gestational age; Bishop score less than or equal to 6.	Multiple babies; Anomalous fetal presentations; Unexplained vaginal bleeding; Abnormal Placentation: Placenta Previa, Vasa Previa or Placenta Accreta; Previous uterine scar; Active liver, kidney, lung or heart disease; systemic or local infectious diseases; allergy to any prostaglandins.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-58pgs4	The influence of Pain Neuroscience Education associated with Meditation on sleep and functional capacity of adults with Fibromyalgia	Data analysis completed	Intervention	2020-08-19	<NULL>	<NULL>	4140	Influence of Pain Neuroscience Education associated with Meditation on quality of life, sleep and functional capacity of elderly people with Fibromyalgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-58pgs4	<NULL>	Being 40 years of age or older, having a medical diagnosis of fibromyalgia, with pain intensity classified as moderate or severe by the Numerical Pain Rating Scale, 0 being considered painless, 1 to 3 mild pain, 4 to 6 moderate pain and 6 to 10 severe pain.	Individuals who showed signs of cognitive decline when scoring below the cut-off point in the Mini Mental State Examination (MMSE) were excluded - in the case of elderly participants; have hip or knee limitations, or difficulties in performing movements at ground level; practice physical activity regularly, corresponding to more than 150 minutes of physical activity weekly; have some acute emotional involvement (an event in the last 5 months that leaves you emotionally vulnerable, such as deaths, accidents and other personal and emotional issues); self-reported obsessive compulsive disorder (OCD); being under fibromyalgia treatment or having undergone it in less than 3 months; having more than 25% of absences in the interventions (equivalent to 3.25 absences).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-62n5qn	Physical training answers on metabolism and body fat of individuals with normal weight, overweight and type 2 Diabetes	Recruitment completed	Intervention	2017-11-01	<NULL>	<NULL>	4141	Combined training answers on inflammation, metabolic factors and serum, molecular and image markers related to brown adipose tissue and browning of white adipose tissue in healthy individuals, with overweight and type 2 Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Educação Física da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-62n5qn	<NULL>	Body mass index (BMI) between 18.5-34.9 kg / m²; insufficiently active; presence or absence of type 2 diabetes.	Disapproval on physical and cardiological examination; presence of certains disease(coronary artery disease, severe arterial hypertension, chronic obstructive pulmonary disease, limiting osteo-articular diseases) or other general or specific/severe complications of T2DM that may interfere with the results of the research or represent a risk factor to the physical training; Use     of exogenous insulin, thiazolidinediones, beta-blockers, anticoagulants to not interfere in the physiological responses to tests or training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-59dvws	Varnish and Neutral Fluoride Gel and Early Childhood Caries	Recruitment completed	Intervention	2019-04-01	<NULL>	<NULL>	4142	Early childhood caries control using varnish and neutral fluoride gel: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-16	Universidade Federal do Piauí	Profa Dra Marcoeli Silva de Moura	https://ensaiosclinicos.gov.br/rg/RBR-59dvws	<NULL>	The inclusion criteria for participation were: age of three and four years old, residing in Teresina, for at least one year, with a fixed address and having a contact phone number, as well as being regularly enrolled in daycare centers.	Children who received topical application of professional fluoride in the six months prior to the survey, did not have teeth with pulpal involvement or systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-5s9bhc	Effects of coconut oil intake on high blood pressure	Recruitment completed	Intervention	2020-08-20	<NULL>	<NULL>	4143	Effects of coconut oil supplementation on blood pressure in hypertensive patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-13	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5s9bhc	<NULL>	Volunteers of both genders; mild hypertensive patients aged between 18 and 65 years.	Volunteers with secondary hypertension; volunteers under pharmacological treatment or using hormone therapy; with a recent history of emergency hospitalization due to the hypertensive crisis; Diabetes Mellitus; and volunteers with pressure levels outside the range of stage I hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3w4xbv	Acute effect of a breath test on heart rate variability and diaphragm muscle mobility in heart transplant recipients	Recruiting	Observational	2020-08-20	<NULL>	<NULL>	4144	Acute effect of the incremental inspiratory load protocol on a frequency variability and diaphragmatic mobility among adults healthy and heart transplanted	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3w4xbv	<NULL>	This study will include adult individuals aged between 18 and 65 years old; of both sexes; who has had heart transplant surgery over a period of 12 months; sedentary; with clinical stability; making regular use of immunosuppressive therapy; no change in medication class within three months prior to the start of the research. Those healthy adult individuals between 18 and 65 years old will be included; sedentary; non smokers; non-drug user; without cardiac involvement.	"Patients using pacemakers will be excluded; with HF reactivation or Chagas disease; smoker; alcoholism; using corticosteroids; with obstructive disorder. In addition to patients who present psychological changes that make it impossible to understand the commands required for evaluation.
All patients with orthopedic diseases will be excluded; musculoskeletal; neurological or respiratory problems that make it impossible to perform the incremental load test; diabetes; patients who induce dialysis or cardiovascular disease; in addition to patients who have psychic changes that make it impossible to understand the commands required for evaluation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-4jx82p	Effect of Supplementation of a Protein specific to body composition in the vein and observation of blood values and mortality in ICU patients after abdominal surgery	Recruiting	Intervention	2020-01-15	<NULL>	<NULL>	4145	Effect of early parenteral alaninaglutamine dipeptide complementation on inflammatory markers and prognostic indexes in critically ill patients after major abdominal surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-09	Eliseuda Marinho da Silva	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-4jx82p	<NULL>	Ages 18-90 years; after major abdominal surgery in ICU; contraindication or failure of enteral nutrition within 48 hours; use of parenteral nutrition for at least 7 days; no history of kidney or liver disease	"Life expectancy greater than 7 days, ie palliative care; unstable hemodynamic state; chronic renal failure where dialysis is insufficient; previous history of severe 24-hour sepsis; liver failure with hepatic encephalopathy or portal hypertension; pre-existing endocrine disorders; continuous 24-hour propofol infusion;
chronic maintenance of systemic steroid therapy; immunocompromise; pregnancy or lactation; severe brain injury;
seizure disorder with anticonvulsant medication; metastatic cancer of lymphoma four; psychiatric history; family members unable to understand the nature and scope of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-85yygn	Nutritional assessment of severe pediatric patients using muscle ultrasound	Data analysis completed	Observational	2020-08-20	<NULL>	<NULL>	4146	Nutritional assessment of severe pediatric patients using ultrasonography of the quadriceps femoris	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Tiago Henrique de Souza	Tiago Henrique de Souza	https://ensaiosclinicos.gov.br/rg/RBR-85yygn	<NULL>	Patients between 28 days and 14 years of age admitted to the pediatric intensive care unit.	Patients with a hospital stay of less than 48 hours; patients with neurodegenerative muscle diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9fb24p	Stretching effects on elderly with high blood pressure	Data analysis completed	Intervention	2020-08-20	<NULL>	<NULL>	4147	Muscle stretching exercise effects on hypertensive elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fb24p	<NULL>	Hypertensive aged between 60 and 80 years of age	Have chronic obstructive pulmonary disease, limited locomotion and mobility and absence on the sessions over than 25%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-8h6qxv	The warm compress in the care of febrile children: Randomized Clinical Trial.	Data analysis completed	Intervention	2020-08-21	<NULL>	<NULL>	4148	Effectiveness of tepid sponging intervention in reducing temperature of children with fever: a pilot randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-11	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitario da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h6qxv	<NULL>	"Will be included in the study children from 1 month to 11 years 11 months and 29 days, who meet the following criteria:Present axillary temperature 37.8ºC; Interval between the administration of the antipyretic and the beginning of the treatment application, application of warm compresses, up to 10 minutes; Have permission from parents or guardians and agree to participate in the study.
In addition to these criteria, it will also be allowed to include the same patient within 12 hours of the last inclusion in the study and not be under the effect of antipyretic, it is necessary to have a minimum of 6 hours of the last antipyretic."	Patients with the diagnosis of malignant hyperthermia; neurological dysfunction; patients to undergo a procedure for up to 3 hours after administration of the antipyretic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3rdhgm	The role of early dialysis in the evolution of patients with COVID19	Recruiting	Intervention	2020-05-14	<NULL>	<NULL>	4149	The role of early acute renal support in the prognosis of patients diagnosed of COVID-19: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3rdhgm	<NULL>	patients over 18 years old; COVID-19 positive by the RT-PCR technique or rapid test; in mechanical ventilation; diagnosis of AKI; hydric balance positive higher then 3% of body weight; hospitalized in the ICU;vusing norepinephrine at a dose of 0.1 to 1 µg / kg / min.	Pregnant patients; patients who were on other types of dialysis support, other than HDP or HDC, that with an emergency indication for RAS; diagnosed with stage 5 chronic kidney disease or need for chronic renal replacement therapy (dialysis or transplantation) will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-5jfjx9	Assessing the Effect of Vitamin C Replacement as an Auxiliary Treatment for Anemia in Chronic Kidney Patients on Hemodialysis	Recruitment completed	Intervention	2020-08-24	<NULL>	<NULL>	4150	Efficacy of ascorbic acid as adjunctive therapy in the treatment of anemia in chronic renal patients undergoing hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Faculdade de Ciências Médicas	Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-5jfjx9	<NULL>	Be part of a hemodialysis program for chronic kidney disease; Be on erythropoietin in any dose, to control anemia of chronic kidney disease; Perform at least three weekly hemodialysis sessions, with a minimum duration of 4 hours each session; Be assiduous at hemodialysis sessions	Do not use any therapies to control anemia of chronic kidney disease; Be a minor; Chronic ascorbic acid use; Failure of vascular access, such as catheters with low blood flow that prevent hemodialysis with flow above 250 ml / min; Critical worsening of health status, such as prolonged hospitalizations in intensive care units, patients undergoing major surgery with prolonged recovery or patients in palliative care for malignant neoplasms; Little attendance with frequent absences from hemodialysis sessions or undergoing hemodialysis during reduced hours or reduced doses; Any acute or chronic condition that limits the patient&apos;s ability to participate in the study, such as advanced heart or liver disease; Have a kidney transplant or recover kidney function in the middle of the study; Malnourished patients, with low body weight, those who use immunosuppressants, chemotherapy, antivirals or immunobiologicals; Patients with a hypersensitivity reaction to some of the research components, such as ascorbic acid or erythropoietin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-2xbvh7	Spine block as analgesic technique in breast cancer surgery. Randomized controlled trial	Recruitment completed	Intervention	2020-08-24	<NULL>	<NULL>	4151	Us - Esp Block (Ultrasound - guided Erector Spinae plane block) as analgesic technique in breast cancer surgery. Randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Faculdade de ciências médicas - Universidade Estadual de Campinas	Centro atenção a saúde da mulher Professor Dr José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-2xbvh7	<NULL>	Elective oncology breast surgeries under general anasthesia; segmentectomy with or withou axilectomy, masctectomy with or without axilectomy and breast reconstruction, american society of anethesia physical status 1, 2 and 3; body mass index lower than 30, Age over than 18 anos; hability to comprehend and answer the numeric visual scale	Patient refusal, history of local analgesics hipersensibility; anatomical deformities interfering the performance of erector spine block, difficult airway, inability to understand the pain score questionnarie, coagulopathies and local infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-84j48n	Fascial manipulation (Stecco method)to reduce orofacial pain, masticatory muscles and TMJ	Data analysis completed	Intervention	2020-08-24	<NULL>	<NULL>	4152	Efficacy of myofascial manipulation - Stecco method - to reduce Orofacial pain and TMD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Florence Mitsue Sekito	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-84j48n	<NULL>	Subjects; of both sexes; aged 18 to 65 years old; presenting muscle and/ or joint disorders associated with temporomandibular disorders. Presence of orofacial pain; and presence of pain in the regions: cervical; cervical-brachial; scapular-humeral; thoracic; musculature of the stomatognathic system; verbal rating scale greater than or equal to 6;  chronic pain lasting more than 4 months; signature of the free and informed consent form  agreeing to become the subject of the research.	Patients with syndromes that could affect the musculoskeletal system in any instance; psychiatric alteration acessed by  BELL axis two; associated fibromyalgia, with previous diagnosis performed by the doctor; associated rheumatological diseases, with prior diagnosis made by the doctor; chemical dependency; neurological disorders and patients with neuropathies; coagulopathies with International Normalized Ratio(INR) index less than two; polytraumatized; edentulous patients without prostheses and / or patients with prostheses without conditions of use; severe arthrosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-88bs9x	"Treatment for Severe Pneumonia in Patients
with Coronavirus."	Recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4153	New Therapeutic Strategies in Patients with SARS-COV-2-Induced Severe Pneumonia.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-04-30	Ministério da Ciência, Tecnologia, Inovações e Comunicações (MCTIC)	Coordenação Geral de Recursos Logísticos (CGLOG)	https://ensaiosclinicos.gov.br/rg/RBR-88bs9x	<NULL>	Patients who meet the requirements for the diagnosis of Coronavirus infection [Characteristic respiratory symptoms (dry cough, fever) associated with a tomographic image of pneumonia compatible with COVID-19 without acute respiratory failure (Oxygen Saturation less than 93% with nasal oxygen catheter at 5 liters / minute); Patients who meet the requirements for the diagnosis of Coronavirus infection [Characteristic respiratory symptoms (dry cough, fever) associated with a confirmatory molecular test for COVID-19 without acute respiratory failure (Oxygen Saturation less than 93% with a 5 liter nasal oxygen catheter /minute); Age greater than or equal to 18 years old man or woman; In women with negative pregnancy test and commitment to the use of contraception throughout the study (provided by the researcher); Willing to take study medication; Able to provide written, informed and / or informed consent even to a family member.	It is not possible to take drugs orally or through a gastroenteric feeding tube; With significantly abnormal liver function (Child Pugh C); Previous renal failure: patients who previously underwent dialysis, or patients with GFR less than or equal to 30 mL / min / 1.73 m2; NYHA (New York Heart Association) heart failure 3 or 4; COPD GOLD 3 and 4; Neoplasia; Autoimmune disease; Individuals with known hypersensitivity to study drugs; People who have already been treated with the study drug during the last 30 days; Clinical or radiological suspicion of tuberculosis and bacterial pneumonia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-99wfvv	Study to evaluate the effectiveness of a gel based on flower essences to control pain, swelling and difficulty opening the mouth after extracting the lower wisdom teeth	Recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4154	Study on the postoperative efficacy of Oxyflower® gel to control pain, edema and trismus after extraction of mandibular third molars	<NULL>	n/a, single-arm-study, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-99wfvv	<NULL>	Patients over the age of 18 years; without compromising general health; with indication of extraction of bilateral third mandibular molars, whether included or not, asymptomatic and in the class IIB position, according to the Pell &amp; Gregory classification and which have similar radiographic characteristics.	Patients with a history of hypersensitivity to any of the components of the medications used; classified as ASA III or ASA IV, according to the American Anesthesiology Association; use of anti-inflammatory drugs in the 15 days prior to surgery; submitted to antibiotic therapy in the last 2 months; patients with tuberculosis, leukocytosis, vascular collagen diseases, multiple sclerosis, HIV infection, and other autoimmune diseases; smokers; pregnant and lactating women; with a history of pericoronaritis; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-6sc7tp	Stimulation in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4155	Stimulation of the Pontino peduncle nucleus area in patients with Parkinson&apos;s disease evaluation of motor results focusing on gait changes falls balance and impact on quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Medicina da Univeridade de São Paulo	Faculdade de Medicina da Univeridade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6sc7tp	<NULL>	"Patients diagnosed with idiopathic PD according to Queen Square Brain Bank criteria 23.
The diagnosis will be given by a neurologist specializing in movement disorders.
Presence of moderate PD, at least 4 years from the onset of motor symptoms.
Persistent motor dysfunction for at least 1 month despite drug adjustment.
Patients with moderate to severe gait disturbances and refractory balance to drug treatment.
Thus, they should have: score 3 (moderate) or 4 (severe) in items 12 and 13 of part II of the MDS-UPDRS and score 3 (moderate) or 4 (severe) in items 9, 10, 11 and 12 of part III UPDRS being on medication (medication status ON).
Cognitive performance appropriate to preoperative care.
Understanding of the stimulation system and recognition of adverse events.
Willingness of the caregiver or family member, and the patient himself, to come in frequent returns to ensure the best brain stimulation parameters."	"Age under 18 years.
Parkinsonism Associated With Other Degenerative Diseases
Secondary Parkinsonism.
Prior surgical treatment of PD symptoms.
Patients without clinical conditions for the surgical procedure due to noncompensated systemic disease.
Behavioral disorders and hallucinations associated with dopamine drug use and without drug control.
Patients with less than two years of schooling or visually impaired who cannot perform properly on neuropsychological tests.
Depression.
Dementia associated with PD
Refusal to undergo neurosurgical procedure.
Refusal to accept the informed consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9xs978	Telehealth for patients with dementia at the Hospital Universitário Walter Cantidio-UFC	Recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4156	Telehealth for patients with dementia  at the Hospital Universitário Walter Cantidio-UFC: Implications of Pandemia by COVID-19 and of a telemedicine program-TELEGERIATRY.	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-06-17	Hospital Universitário Walter Cantidio	Faculdade de Medicina da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9xs978	<NULL>	Diagnosis of Dementia Syndrome according to the Diagnostic Criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V); be registered in the dementia outpatient clinic of the Geriatric Service of the Hospital Universitário Walter Cantídio; at least one face-to-face consultation record in the 12 months prior to the telehealth consultation; accept to participate of the video call consultation and of the study.	First consultation; do not accept to participate in the teleconsultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9243v7	Remote exercise program for older adults on the waiting for physical therapy after hospital discharge: a clinical trial with economic evaluation	Not yet recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4157	Telerehabilitation exercise program to maintain the conditioning of older adults on the waiting list for physical therapy after hospital discharge: a pragmatic trial with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9243v7	<NULL>	Individuals who are 60 years or older who are discharged from hospital with physical therapy referral; able to walk independently or with a walking device or another person help; allowed to do weight bearing with the lower limbs; able to sit and stand from a chair; have a stable clinical condition; able to understand instructions and answer examiner commands during the tests; have a smartphone with internet access (of their own or of their companion/caregiver); have a companion/caregiver who will be present during exercises.	Individuals who present clinical complication that makes physical exercise prohibited; present neurological health conditions such as Parkinson Disease and Stroke; Mini Mental Examination scores lower than proposed by Bertolucci et al (2014); and inability to understand or complete the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-2z3f7k	Artificial ventilation setting in patients infected with COVID-19	Recruiting	Intervention	2020-05-04	<NULL>	<NULL>	4158	Individualized PEEP setting in patients with Acute Respiratory Distress Syndrome: ventilatory strategy in the COVID-19 pandemia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-29	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-2z3f7k	<NULL>	Age 18 to 80 years; Mechanically ventilated patients with   COVID-19 infection suspicious	"Pregnancy confirmed by laboratory tests;
• Weight below 35 kg; Patients undergoing endotracheal intubation as a result of exacerbation of chronic lung disease; Radiological aspects compatible with pulmonary fibrosis, consolidation of the lung parenchyma, tumor masses and emphysema; Patients with pneumatocele; Pneumothorax, subcutaneous emphysema and pneumomediastinum documented and not resolved; Patients with heart failure previously classified as functional class III or IV according to the New York Heart Association (NYHA); Patients with acute coronary syndrome or persistent ventricular tachyarrhythmias; Mean arterial pressure (MAP) less than 65 mmHg with a dose of norepinephrine 0.5 to 1.0 mg / kg / min; Acute brain injury or high intracranial pressure, that is, greater than 18 mmHg;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-75xk9k	The Effect of Touch and Use of Sucrose for Toothache During Breathing in Premature Babies.	Recruitment completed	Intervention	2020-08-25	<NULL>	<NULL>	4159	The Effect of Facilitator Touch and Use of Sucrose on Pain Relief During Aspiration Procedure in Premature Newborns - Randomized Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-25	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-75xk9k	<NULL>	"Preterm newborn (gestational age between 25 and 36 weeks and 5 days); hemodynamically stable, with sedation
or without sedation; on mechanical ventilation or CPAP or nasal catheter of
oxygen or in ambient air; with cardiac and respiratory monitoring other than
are experiencing respiratory distress or decreased saturation of oxygen and requiring aspiration of the orotracheal tube and / or airway higher."	"Newborns with genetic syndromes; major malformations and
congenital infections."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3yb4b9	Evaluation of genetic instability and cytotoxicity in professionals who work in surgical center of the veterinary hospital and are exposed to isoflurane anesthetic	Not yet recruiting	Observational	2018-01-25	<NULL>	<NULL>	4160	Evaluation of genetic instability and cytotoxicity in professionals who work in surgical center of the veterinary hospital and are exposed to isoflurane anesthetic	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)	Departamento de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-3yb4b9	<NULL>	Have at least one year of operation in the surgical center; surgery of small and large animals; animal husbandry; animal reproduction; sádios volunteers; both genders; age between 18 and 60 years	Carriers of malignant disease; infectious diseases: inflammatory; heavy use of alcohol; of &quot;illicit drugs&quot;; medicines; vitamin supplementation; work in some area with occupational exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-58t68w	The effects of a home contemporary dance video program on body balance, functional mobility, cognitive function, quality of life, pain and vulnerability in people with Parkinson&apos;s Disease	Recruitment completed	Intervention	2020-08-25	<NULL>	<NULL>	4161	"Parkinson&apos;s Pisease and physiotherapy: analysis of the repercussion of
intervention programs with terrestrial physical activities and
aquatics – PHYSIOPARK"	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-58t68w	<NULL>	People with PD in stages 1 to 4 of the HY scale; aged over 60 years; with a PD medical report authorizing physical exercise; levodopa intake stabilized for at least 4 weeks.	People with balance disorders secondary to other diseases, cognitive impairment that disables the comprehension of exercises. Claudication of different etiologies, use of neuroleptics, people without independent walking or with problems in the hip joint. Participants who for some reason do not finish any of the evaluations will also be excluded from the research analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-72386w	Responsiveness to induced stress in students of the Health Sciences at the University of Brasilia	Data analysis completed	Intervention	2020-08-25	<NULL>	<NULL>	4162	Assessment of physiological responses to induced stress in undergraduate students of the health sciences at the University of Brasilia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-72386w	<NULL>	Healthy volunteers. Both sexes. Undergraduate students of the health sciences at the University of Brasilia Campus of Ceilandia. Age between 18 and 30 years.	Use of controlled medication. Severa arrhythmia. Serious neurological conditions. Use of pacemaker. Allergy to any of the materials used in the experiments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-48mgvh	Regional Anesthesia for Clavicle fractures.Comparisom between two techniques	Recruiting	Intervention	2020-08-25	<NULL>	<NULL>	4163	Clavipectoral fascia block associated with superficial cervical plexus block versus superficial cervical plexus block in clavicle surgery. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Diogo Bruggemann da Conceição	Hospital Governador Celso Ramos	https://ensaiosclinicos.gov.br/rg/RBR-48mgvh	<NULL>	All patients aged between 18 and 74 years who are admitted to the Governador Celso Ramos Hospital with a clavicle fracture and indication for surgical approach will be included in the study.	Patients who refuse to participate and patients with a body mass index greater than 40 kg / m2  will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-6rc23h	Effect of violet light on in-office dental bleachings: 12 months follow-up	Data analysis completed	Intervention	2020-08-25	<NULL>	<NULL>	4164	Dental bleaching using violet LED associated or not with 37% carbamide peroxide: a randomized double-blinded clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-21	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-6rc23h	<NULL>	Sign the consent form; availability to attend all sessions; age between 18 and 35 years; good health, controlled blood pressure, and adequate oral hygiene; pulp vitality in the teeth to be bleached (1st PM on one side to 1st PM on the opposite side in the upper and lower arches); color of teeth above A2 on the VITA scale, visually identified.	Smoker; pregnant or lactating; heart problems; history of known reaction to peroxides; individual or family history of neoplasia in the oropharynx region and surroundings; history of diabetes or other systemic diseases, which can interfere with the access of tissues from the oral cavity; need antibiotic therapy before dental prophylaxis; presence of oral pathologies, xerostomia, caries lesions, extensive restorations of composite resin, fractures or splinters in the teeth, gingivitis/periodontitis, bruxism, which in the professional&apos;s opinion may compromise the participant&apos;s health or the results of the study; presence of surface irregularities, tetracycline stain, discoloration due to trauma, fluorosis, hypoplasia, dental implant, prosthesis and/or endodontic treatment in upper or lower anterior teeth, or other parameters that may make it difficult to measure tooth color; have made use of bleaching agents in the office or at home in the last year (does not include toothpaste or bleaching mouthwash); spontaneous tooth sensitivity; intention to put a fixed orthodontic appliance during the bleaching assessment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-7tj48w	Effect of turmeric supplementation on oxidative stress and inflammatory markers after endurance exercise	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4165	Effect of Curcuma longa L. supplementation on oxidative stress and inflammatory markers after endurance exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Tatyanne Letícia	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7tj48w	<NULL>	Healthy men aged between 20 to 40 years; able to complete all study assessments	In the use of medications or nutritional supplements; alcoholic beverages; on a diet or dietary restriction; using turmeric as a condiment at meals in the last seven days before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2kjm6y	A phase 2 randomized double-blind placebo-controlled study to evaluate safety of BLD-2660 and its activity against COVID-19 virus in hospitalized subjects recently diagnosed with COVID-19 in comparison to standard of care treatment	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4166	A phase 2 randomized double-blind placebo-controlled study to evaluate safety and antiviral activity of BLD-2660 in hospitalized subjects with recently diagnosed COVID-19 compared to standard of care treatment	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-22	Blade Therapeutics Inc	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-2kjm6y	<NULL>	At least 18 years of age at the time of signing the ICF. Hospitalized for COVID-19. Diagnosed with COVID-19 as defined by having at least 2 of the following signs or symptoms within the past 2 days: a.fever defined as a body temperature higher than 38.0°C oral, or higher than 38.3°C rectal, higher than 37.7°C forehead or higher than 38.7°C aural (axillary temperatures are not allowable); b.cough; c.fatigue; d.shortness of breath. Radiographic evidence (chest x-ray or CT scan) of one the following: a. ground-glass opacities, or b.local or bilateral patchy infiltrates, or c.interstitial pulmonary infiltrates. Oxygen requirements: a. spO2 higher than 94% on ambient air or b.requires supplemental oxygen administration by nasal cannula, simple face mask, or other similar oxygen delivery device. Male and/or female subjects. Contraception use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. All subjects (male or female) who are of childbearing potential must agree to use highly effective contraception during the study. Female subjects and male partners of female subjects must continue to use highly effective contraception for 30 days after the last dose of study drug. Female subjects should not donate oocytes during this time. Male subjects and female partners of male subjects must continue to use highly effective contraception for 90 days. Male subjects must agree not to donate sperm during this time. Women of childbearing potential must have a negative serum pregnancy test at screening within 72 hours prior to first administration of study drug. Women not of childbearing potential must be postmenopausal (defined as cessation of regular menstrual periods for at least 1 year. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the ICF and in this protocol	"Active bacterial pneumonia infection. Known active tuberculosis (TB). History of Child-Pugh B or C cirrhosis. History of ischemic heart disease or myocardial infarction or acute coronary syndrome. Subjects requiring supplemental oxygen higher than 0.75 FiO2. It is not in the best interest of the subjects to participate, in the opinion of the treating
Investigator. Female subjects who are pregnant or breastfeeding or expecting to conceive within the projected duration of the study, starting with the screening visit through 90 days after the last dose of study drug. The following laboratory parameters are excluded:
alanine aminotransferase (ALT) or aspartate aminotransferase (AST) higher than 5 x upper limit of normal (ULN); creatinine clearance lower than 50 mL/min. Requiring, or expected to require mechanical ventilation at screening. Treatment with chloroquine or hydroxychloroquine at study entry. Treatment with anti-IL-6, anti-IL-6 receptor antagonists, or with Janus kinase inhibitors (JAKi) in the past 30 days or plans to receive during the study period. Participation in any other clinical study of an experimental drug treatment for COVID-19 within 6 half-lives of the experimental treatment. Current participation or have participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study drug. Unable to swallow solid oral medication or known malabsorption disorder. Subjects who have allergy to BLD-2660 or inactive components of BLD-2660"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-99j3h4	Neurosensory Posturotherapy in individuals after Stroke	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4167	Comparison between the effect of the Neurosensory Posturotherapy and Mulligan technique on the quality of life and respiratory function of individuals after a Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Norte do Paraná, UENP	Universidade Estadual do Norte do Paraná, UENP	https://ensaiosclinicos.gov.br/rg/RBR-99j3h4	<NULL>	Volunteers affected by Stroke; both genders; age between 18 and 90 years; hemodynamically stable; members of a conventional physiotherapy program	Undisciplined or uncooperative volunteers; absence of medical clearance for the intervention; ; bone disease with risk of fracture; recent fracture; joint effusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-5gwknk	Analgesia and sedation to guarantee painful venous access in children not intubated.	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4168	Analgesia and sedation for procedures in pediatric patients on spontaneous ventilation: a randomized controlled trial comparing the combination ketamine and dexmedetomidine versus usual care (ASSURE Study)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-13	Hospital Universitario da Universidade de São Paulo	Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5gwknk	<NULL>	To compare the success rates of invasive procedures, such as the insertion of a central venous catheter and peripherally inserted central venous catheter in children on spontaneous ventilation with the use of the combination ketamine and dexmedetomidine versus usual care (habitual sedoanalgesia performed in each of the participating units).	Patients in whom the passage of central venous catheter or peripherally inserted central venous catheter receiving invasive ventilatory care, those receiving sedoanalgesia (except with dipyrone, paracetamol and anti-inflammatory) and those with contraindications to the drugs studied were indicated. Patients who did not have the free and informed consent form signed by their parents or guardians.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-24td8t	Effect of baru consumption on the blood fat profile of people with excess body fat and its relationship with genetics.	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4169	Effect of baru seed consumption on lipid profile of individuals with excess body fat: relation with apolipoprotein E genotype	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Medicina da Universidade Federal de Goiás	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-24td8t	<NULL>	The sample of this study included individuals between 20 and 59 years (age range adopted in the matrix study) who agreed to participate in the study, with BMI between 18.5 kg/m² and 24.99 kg/m² (WHO, 2005), percentage of body fat above the established parameters, according to sex and age range (POLLOCK; WILMORE, 1993), who did not habitually consume nuts (more than twice a week) and had increased cholesterol in low-density lipoproteins (LCL-C) serum concentrations, according to the Brazilian Society of Cardiology (SBC, 2013), confirmed by biochemical exams .	Individuals taking lipid-lowering drugs and/or vitamin and mineral supplements; who had allergies to nuts; under nutritional accompaniment; women who were pregnant, in menopause or hormone replacement therapy; patients presenting with acute clinical conditions such as infection, inflammation, fever or diarrhea, or chronic diseases such as diabetes mellitus, moderate/severe arterial hypertension, cancer, rheumatoid arthritis; subjects who were smokers or practiced moderate to intense physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-6bzfrn	Effect of a calming medication on reducing anxiety before wisdom tooth removal	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4170	Effectiveness of sublingual alprazolam in reducing anxiety in impacted third molar surgery - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Hospital Universitário da Universidade Federal de Sergipe	Hospital Universitário da Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6bzfrn	<NULL>	Patients over 18 years; Systemically healthy patients;Presence of asymptomatic impacted third molars; third molars classified as IIB by Pell and Gregory Classification.	Pregnancy or lactation; History of Allergies to drugs or substances used in this experiment; Patients on therapeutic use of psychiatric drugs; menstrual period women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9737g8	Non invasive Brain stimulation in children and adolescents with Autism	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4171	Transcranial direct current stimulation in children and adolescents with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Universidade Federal de São Paulo	Centro Paulista de Neuropsicologia	https://ensaiosclinicos.gov.br/rg/RBR-9737g8	<NULL>	Diagnosis of ASD, according to DSM-5; age between six and 12 years; perform behavioral and or drug treatment for ASD; inserted in the regular school; understanding and collaboration compatible with the performance of the proposed activities; parents agree with their participation in the study by signing the Free and Informed Consent Form.	children whith other neurological or psychiatric disorders; with epilepsy; who have a metallic implant in the brain and children with intellectual, sensory or motor disabilities that limit the performance of neuropsychological procedures and motor activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8jfg9v	Is cryotherapy applied with a protective towel in the elderly able to reduce skin temperature?	Not yet recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4172	Is cryotherapy applied with a protective towel in the elderly capable of reaching the therapeutic temperature? Randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Programa de Pós Graduação em Ciencias da Reabilitação (PPGCR/UFSC)	Programa de Pós Graduação em Ciencias da Reabilitação (PPGCR/UFSC)	https://ensaiosclinicos.gov.br/rg/RBR-8jfg9v	<NULL>	The inclusion criteria for participating in the study are being 60 years old or older; both genders; resident of the city of Lages / SC; agreeing to participate in the study and abstaining from caffeine, tobacco, alcohol at least 1 hour before the intervention in the collection days.	Participants with skin lesions on the lower limbs will be excluded from the sample; changes in sensitivities related to cold; peripheral cardiovascular or vascular disease; musculoskeletal or neurological pathological conditions; smokers; diabetics; use of anti-inflammatory medication at least 2 hours before collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-4b32m3	The effect of the drug Trazodone on motor symptoms of Parkinson&apos;s Disease.	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4173	Motors Effects in Parkinson&apos;s Disease by the action of 5-HT2a/c antagonistic drug mediated by ELF2-alpha factor phosphorylation pathway in humans. A Double-Blind Randomized Controlled Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-10	Universidade Federal da Integração Latino-Americana do Brasil (UNILA).	Universidade Federal da Integração Latino-Americana do Brasil (UNILA).	https://ensaiosclinicos.gov.br/rg/RBR-4b32m3	<NULL>	Individuals with PD clinically diagnosed according to the London Brain Bank criteria. Individuals who voluntarily agree with the procedures and information of the Free and Informed Consent Form. Have cognitive function that allows the understanding of past information by the researcher during the tests (Mini Mental State Examination). Do not present conditions that hinder or impede the movement of the upper limbs, such as: surgeries in the last 12 months; musculotendinosus injuries; fractures; use of prostheses or prostheses; other associated neurological or neurodegenerative conditions; etc. Individuals classified in phase 3 of the Hoeh and Yahr scale.	Withdrawal from participation in the research. Incomplete completion of the instruments. Individuals with treatment abandonment. Patients with symptoms of parkinsonism induced by exogenous intoxication, infectious, vascular, metabolic, genetic causes, other degenerative diseases or by drugs - such as dopaminergic receptor blockers, anticholinesterases, anticonvulsants, antiarrhythmics, reserpine, tetrabenazine, alfamethyldopa, lithium and fluoxetine. Patients who do not want to stop using monoamine oxidase (MAO) inhibitor drugs. Patients who do not interrupt the use of monoamine oxity (MAO) inhibitor drugs in 15 days before the start of the survey. MAO inhibitors are considered, among others, the following medications: Phenelzine; Iproniazid; Isocarboxazide; Harmalina; Nialamide; Pargyline; Selegiline; Toloxatone; Tranilcipromina. Patients who need to use the linezolid antibiotic, digoxin or phenytoin during the experiment. Diabetic patients or patients with other chronic diseases. Individuals with cardiac disorders or in the recovery phase of an acute myocardial infarction . Patients with reports of psychological disorders such as schizophrenia or bipolar disorder. Patients with renal or hepatic impairment. Pregnant or lactating patients. Patients who have changed the treatment of PD in the past 03 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-3bjk6c	Use of the platelet and leukocyte-rich membrane in maxillary sinus lift surgery	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4174	Use of L-PRF in maxillary sinus surgery: randomized triple-blind clinical trial	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2019-06-08	Universidade de Pernambuco - UPE	Universidade de Pernambuco - UPE	https://ensaiosclinicos.gov.br/rg/RBR-3bjk6c	<NULL>	Volunteer patients from the spontaneous demand of the Brazilian Dental Association of Pernambuco section; Classified according to the American Society of Anesthesiology as group 1; Over 21 years old; Indication of bilateral maxillary sinus surgery for subsequent rehabilitation with dental implants; Agreement to participate in the research after reading the informed consent form.	Presence of systemic disease; Use of any medication that may interfere with bone metabolism; Smokers; History of pre- or post-operative sinusitis; Surgical approaches previous to the maxillary sinus; History of bone regeneration surgery or previous implantation in the region; Tooth loss in the posterior maxilla less than 1 year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9sy4bz	Effects of two Heating Protocols on Surface Temperature and Functional Performance in Amateur and Recreational Soccer players.	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4175	Evaluation of the Acute Effects of Two Heating Protocols on Surface Temperature and Functional Performance of Lower Limbs of Amateur and Recreational Soccer players.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-14	Fapemig	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-9sy4bz	<NULL>	Male players; Age between 18 and 30 years; Trainings up to 3 times a week; Participating in championships; Without lower limb dominance restriction; Without restriction of operating position.	"History of kidney problems; Physiotherapy in the last two days; Consume any diuretic or antipyretic and any food supplement: such as creatine that may interfere with water or homeostasis body temperature in the last two weeks;
Smoker; Burns on the skin; With topical treatments creams, ointments or lotions; Pain symptoms in any region of the body; Fever in the last seven days; Sleep disorders; Comply with the criteria for musculoskeletal injuries of the Research and Medical Evaluation Center of the International Football Federation;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-44rxxt	Effect of visceral physiotherapy in patients with low back pain	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4176	Effect of visceral physiotherapy in patients with low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Grupo de Pesquisa em Fisioterapia Avaliativa e Terapêuticas - GPFAT	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-44rxxt	<NULL>	30 individuals with chronic low back pain; regardless of gender; aged between 18 and 50 years; participating in the Clinic	volunteers with depression; anxiety; Brain stroke; Parkinson&apos;s; Alzheimer&apos;s; in addition to menstrual changes such as metrorrhagia; they must not have a history of digestive cancer; appendicitis; peritonitis; polyps; diverticulum; intestinal occlusion and malabsorption syndrome; use of analgesic and contraceptive medication for more than six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8n8csf	Effect of Mesenchymal stem cells in patients with decompensated cirrhosis	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4177	Bone marrow mesenchymal stem cells in acute-on-chronic liver failure grades 2 and 3: a phase I-II randomized clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2018-09-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8n8csf	<NULL>	fulfilling ACLF diagnostic criteria and ACLF grade 2 or 3	patient’s or family member’s refusal; (b) hepatocellular carcinoma (HCC); (c) formal contraindicationfor liver transplantation (e.g. advanced heart or pulmonary disease); (d) pregnancy and lactation; (e) previous liver transplantation; (f) HIV co-infection; (g) ACLF grade 1; (h) patients admitted for elective procedures; (i) renal chronic disease requiring dialysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-65pmwy	Effect of Vibration treatment in women with Urine Loss on exertion	Recruiting	Intervention	2020-03-10	<NULL>	<NULL>	4178	Effect of whole body Vibration on pelvic floor muscles in women with Stress Urinary Incontinence: a randomized double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-65pmwy	<NULL>	women with stress urinary incontinence and who are not undergoing any other physiotherapeutic treatment for urinary loss at the time of the research.	Patients with pacemakers or cardiac implants; metallic grafts; acute urinary tract infection; epilepsy, decompensated hypertension, BMI above 40 kg / m2; with a physical disability that unable to receive the intervention or the assessment tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-34fjqk	"Effect of Transcutaneous Nerve Electrical Stimulation in the System
Autonomic cardiovascular autonomic of patients with fibromyalgia: a study
randomized"	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4179	"Analysis of the Effect of Transcutaneous Nerve Electrical Stimulation in the System
Autonomic cardiovascular autonomic of patients with fibromyalgia: a study
randomized"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	Universidade Federal de Sergipe	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-34fjqk	<NULL>	Patients with fibromyalgia evaluated according to the classification criteria of the American College of Rheumatology; female; aged between 18 and 60 years; sedentary;  no cardiovascular diseases.	"Neurological and rheumatic diseases associated with FM; any other characteristic that
maintenance of electro-stimulation; current intolerance; electrode allergy; any skin contact material; presence of
pacemaker; pregnancy; other absolute indication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-7ddbn3	Oral rehabilitation of elderly people with reduced alveolar bone height: conventional complete denture retained by prosthetic adhesive versus single-implant overdenture	Recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4180	Oral rehabilitation of elderly people with low bone height: conventional complete denture retained by prosthetic adhesive versus single-implant overdenture	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-06-30	Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7ddbn3	<NULL>	The study will include elderly people aged 60 years or older; totally edentulous in both dental arches, having (or not) upper and / or lower PTs considered unsatisfactory, according to Vigild&apos;s criteria (Vigild et al., 1987); must have lower residual edges classified as types III and IV, according to the American College of Prosthodontics (McGarry et al. 1999); they must present a minimum anterior bone height of 11 mm (assessed by means of panoramic radiographic examination), which is considered compatible with the 9 mm long implant installation.	Volunteers with cognitive impairment (assessed using the Addenbrooke Cognitive Exam, ACE-R), salivary flow below 0.6 mL/min, parafunctional habits and / or temporomandibular disorders (assessed according to RDC/TMD) will be excluded from the study, uncontrolled systemic diseases (confirmed through prior medical evaluation), and who have experience with the use of prosthetic adhesives. Volunteers with a history of neurological diseases, such as ischemic or hemorrhagic stroke, traumatic brain injury, Parkinson&apos;s disease, Alzheimer&apos;s disease, smokers or alcoholics, or those who have undergone radiotherapy in the head and neck region will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9wf5v4	Clinical performance of two different resins in dental cavity restoration	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4181	Evaluation of the clinical effectiveness of two resin compounds for the restoration of non-carious cervical lesions	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2019-01-13	Centro Universitário Católica de Quixadá	Centro Universitário Católica de Quixadá	https://ensaiosclinicos.gov.br/rg/RBR-9wf5v4	<NULL>	Voluntary patients of both sexes, aged between 18 and 60 years, who had at least two non-carious cervical lesions distributed in different hemiarchies. patients without periodontal disease and without veneers or veneers in the teeth affected by non-carious cervical lesions.	Patients with active caries lesion on the remaining teeth of the arch. Unsatisfactory restorations. Recent restorations involving the vestibular surface. Inadequate oral hygiene. Teeth with mobility. Use of orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2vt6tx	Effects of video games on functional capacity, quality of life and molecular data of elderly people living in long-term care facilities	Recruitment completed	Intervention	2020-08-26	<NULL>	<NULL>	4182	The impact of gametherapy on clinical-functional outcomes, quality of life and biomarkers in peripheral blood of institutionalized elderly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-2vt6tx	<NULL>	To be 60 years or older; be residing at the research site.	Use lower limb prostheses; neuropaths with motor deficit; be undergoing chemotherapy or hemodialysis; bedridden elderly; cognitive deficit; use drugs containing HDAC inhibitor; inability to communicate; not having medical clearance to perform physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-6bp3hk	Effect of Oat supplementation and Physical Activity on glucose and cholesterol control and weight loss in the elderly	Recruitment completed	Intervention	2020-08-27	<NULL>	<NULL>	4183	Effect of oat consumption and physical activity in the elderly in Mossoró / RN	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Paloma Katlheen Moura Melo	Paloma Katlheen Moura Melo	https://ensaiosclinicos.gov.br/rg/RBR-6bp3hk	<NULL>	The study included: 60 elderly people, aged 60 to 90 years, of both sexes; with a higher / equal score of 17 points in the Mini-Mental State Examination (MMSE); with a level of physical fitness classified as active; participants in a Pro-life program: physical activity and quality of life, attended at NAFEL / UERN	The elderly who had other physical and / or intellectual conditions were excluded from the research process; having celiac disease; elderly people who did not eat orally	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-72bg24	SARS-CoV-2 quick analysis in breath device	Not yet recruiting	Intervention	2020-08-27	<NULL>	<NULL>	4184	Technical feasibility studies for the diagnosis of Covid-19 by rapid non-invasive test	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-31	Instituto de Tecnologia do Paraná	Tera Brasil	https://ensaiosclinicos.gov.br/rg/RBR-72bg24	<NULL>	"Male and Female; Above 18 years old; 
The patient must accept and sign a form of willing and informed consent; The SARS CoV-2 carrier’s status shall be determined in a sample collected during the breath analyzed test (BAT); Outpatient cases; Symptomatic and asymptomatic."	Hospitalized patients; Subjects under general anesthesia; The incapacity of personally sign the consent form; The incapacity of blowing 5x in the test; BAT samples analyzed after 6h; Impossibility of obtaining a second sample; Symptomatic patients with over 5 days of symptoms for the first PCR sample or over 7 days for the repetition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9s3fbm	Evaluation of Pilates Method exercises in Individuals with Chronic Low Back Pain	Recruitment completed	Intervention	2020-08-27	<NULL>	<NULL>	4185	Evaluation of the Pilates method on functional capacity and quality of life in individuals with Nonspecific Chronic Low Back Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-12	Universidade de Pernambuco - UPE	Universidade de Pernambuco - Campus Petrolina	https://ensaiosclinicos.gov.br/rg/RBR-9s3fbm	<NULL>	"The study included individuals aged between 18 and 59 years, of both sexes, presenting symptoms of pain or stiffness in the pelvic loin region with or without symptoms of irradiation to the lower limbs, on most days of the week, for more than three months, in addition to a good understanding of written and spoken Portuguese. Regarding the level of physical activity, irregularly active A and B and sedentary individuals will be included according to the International Classification of Physical Activity Level Assessment.
Individuals classified irregularly active perform physical activity, but insufficient to be classified as active, as they do not comply with the recommendations regarding the frequency or duration of physical activity. In order to carry out this classification, the frequency and duration of different types of activities are added, such as moderate and vigorous walking, being divided into two subgroups according to the fulfillment or not of some of the recommendation criteria: Irregularly active A is one that reaches at least least one of the recommendation criteria regarding frequency or duration of activity: Frequency: 5 days a week or
lasting 150 min per week. Irregularly active B: one who did not meet any of the recommendation&apos;s criteria for frequency or duration. Sedentary: Individuals classified as sedentary include those who have not performed any physical activity for at least 10 continuous minutes during the week. In addition to the criteria described above, individuals with chronic low back pain classified according to the STarT Back Screening Tool Brazil with low and medium risk of poor prognosis for physical therapy treatment due to the influence of psychosocial factors (HILL et al., 2011) were included in the study.
Low risk of poor prognosis (between 0-3 points on the total score): presence of minimal physical and psychosocial factors.
Medium risk (values ??greater than 3 in the total score and a subscale of 3 points); presence of physical and psychosocial factors, but at lower levels than individuals classified as high risk."	Exclusion criteria consisted of participation in a Pilates exercise program or other therapeutic exercises in the last six months, schedule or history of spinal surgery, unexplained loss of weight or appetite, history of cancer or malignancy, cauda equina injury, loss of bladder or bowel control, saddle paresthesia, pregnancy, spine fractures, rheumatological diseases, inflammatory diseases and; or infectious of the spine, comorbidities that could prevent the practice of exercises, in addition to being classified as high risk for disability prognosis, according to SBST Brasil, and not consenting or signing the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2mt78b	Interference of Methotrexate Tuberculosis Latent Screening Tests and its relation with the clinical, immunological and inflammatory activity of Psoriasis	Data analysis completed	Intervention	2018-06-05	<NULL>	<NULL>	4186	"Interference of Methotrexate on QuantiFERON TB-Gold in Tuberculosis Screening
Latent and its relation to the clinical, immunological and inflammatory activity of Psoriasis"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2mt78b	<NULL>	Moderate to severe psoriasis; referred by dermatologists with indication of methotrexato use; aged over 18 years; living in the northeast region.	Abscence of BCG vaccination scar; pregnant women; women breastfeeding; previous use of immunosuppressant treatment; Topical use of medication for less than 6 months; lithium use; personal history; signs or symptoms of tuberculosis; chest X-ray compatible with lung disease; previous malignancy; positive serology for HIV, hepatitis B or C; liver enzyme elevation 3-fold above baseline; renal clearance less than 60 ml / min; lymphopenia below 1500 lymphocytes; platelet count below 100,000; or leukopenia below 3500 leukocytes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2sh88b	Comparison between Himalayan salt and common salt in urinary sodium values and blood pressure of hypertensive individuals	Recruitment completed	Intervention	2020-08-29	<NULL>	<NULL>	4187	Comparison between Himalayan salt and common salt in urinary sodium values and blood pressure of hypertensive individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Medicina da Universidade Federal de Goiás	Faculdade de Medicina da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2sh88b	<NULL>	Women; Age between 40 and 60 years; Diagnosis of essential hypertension, stable blood pressure and no change of medications in the last 60 days.	Decompensated heart failure; Stroke in the last 6 months; Acute myocardial infarction less than 3 months old; Decompensated diabetes (glycated hemoglobin above 8) liver disease characterized by transaminase values 3 times higher than reference value; Hypothyroidism; Renal disease, with a glomerular filtration rate lower than 60mL / min / 1.73m2SC; Illicit drug users; Alcoholics (more than 1 dose / day for women and 2 doses / day for men) 1; Patients with uncontrolled psychiatric disorders; Patients with medication change in the last 60 days and / or during the intervention; Patients who eat their meals in places where they can not prepare them with the salt of this study more than once a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8rm3xh	Program P: a gender transformative intervention targeting parents to reduce violence against women and children in Bolivia	Recruitment completed	Intervention	2020-08-29	<NULL>	<NULL>	4188	Program P: A Gender Transformative Intervention Targeting Parents to Reduce Violence Against Women and Children in Bolivia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Banco Interamericano de Desenvolvimento- IADB	Banco Interamericano de Desenvolvimento- IADB	https://ensaiosclinicos.gov.br/rg/RBR-8rm3xh	<NULL>	Househols with both parents; children under 3 years old; living in District 8 in El Alto	Relocate to another city before randomization;  parents do not share the same household	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-53s3rk	Functional and strength training in parkinsonians	Data analysis completed	Intervention	2013-09-05	<NULL>	<NULL>	4189	Influence of functional and strength training on neuromuscular adaptations, functionality quality of life, and intracellular mechanisms associated with the muscle weakness in elderly with parkinson&apos;s disease	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2013-03-01	Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53s3rk	<NULL>	"All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional.
All patients must present the clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist, to present between 50 and 80 years of age, to present Parkinson&apos;s disease between stages 2 and 3, do not perform regular exercise weights six months before starting the training intervention."	Patients who present symptoms of dementia, depression, joint problems, hypertension and stroke will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9bwxcx	Effect of red and infrared light for localized fat reduction in the abdomen	Not yet recruiting	Intervention	2019-04-15	<NULL>	<NULL>	4190	Effect of Photobiomodulation on reduction of abdominal measurements: Clinical, randomized, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Associação educacional Nove de Julho	Associação educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9bwxcx	<NULL>	Men and women, 25-45 years old, with BMI between 18.5 kg / m2 to 29.9 kg / m2 will be included; with abdominal fat equal to or greater than 20mm and who agree with the participation in the research by signing the consent form.	The following people will be excluded from this survey: those participants who are undergoing aesthetic treatments to reduce waist circumference; those who have been previously submitted to abdominoplasty or liposuction surgeries; those who are on a diet, in order to reduce their measurements; those people who engage in a physical activity more than two times a week; those who are using or have taken drugs or food supplements in last 90 days, in order to reduce their measurements and their weight, which may affect their lipid metabolism, appetite or nutrients absorption; those who have been submitted previously to oophorectomy; those with signs and/or symptoms of climacteric at the menopause; pregnant or lactating women; those participants who are not regular in attending the sessions; those participants who present metabolic dysfunctions (diabetes and thyroid disorders), cardiovascular problems (hypertension, cardiac insufficiency, arrhythmia, thrombosis, pacemaker use), respiratory issues (asthma, chronic obstructive pulmonary disease), haematological disturbances (anaemia), renal, non-alcoholic fatty liver disease, dermatological or digestive disorders (gastritis, ulcers); those with a history of oncological pathology; those with cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8yqbfr	Clinical performance of flowable resin composites with bioactive technology and resin-modified glass ionomer cement in noncarious cervical lesions of abfraction: a randomized control clinical trial	Not yet recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4191	Clinical performance of flowable resin composites with Giomer technology and resin-modified glass ionomer cement in abfraction lesions: a randomized control clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8yqbfr	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-6ft5yb	Risk factors in orthopedic prosthesis surgeries	Data analysis completed	Observational	2020-08-31	<NULL>	<NULL>	4192	Multiresistant gram-negative bacteria infections&apos; risk factors in orthopedic prosthesis surgeries	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Fundação Hospitalar São Francisco de Assis	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ft5yb	<NULL>	Have more than 18 years old; Have prosthesis of hip or knee joint replacements with primary arthroplasty surgery performed from January 2014 to December 2017 at the Hospital; Evolve from January 2014 to December 2017 with prosthesis infection defined by the following Muscolosketal Infection Society (MIS) criteria; In order to be considered a representative sample, the sample sent for culture should meet the following criteria: Collection of bone fragment or Deep tissue such as muscle tissue and fascia or Periprosthetic tissue or capsule or Aseptically collected synovial fluid; Identification of Gram-negative bacteria: Negative agents are identified by conventional biochemical and metabolic tests carried out in the agreed laboratory and in accordance with international norms.	Be under 18 years; Possessing prosthesis of hip or knee joint replacements with primary arthroplasty surgery performed in another institution; Evolution of infection outside the period from 2014 to 2017.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-5pckyr	Capsaicin supplementation combined with aerobic exercise on food intake in young adults	Data analysis completed	Intervention	2020-07-24	<NULL>	<NULL>	4193	"Influence of acute capsaicin supplementation combined with aerobic exercise
dietary intake of physically active young people"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-19	Fábio Santos Lira	Priscila Almeida Queiroz	https://ensaiosclinicos.gov.br/rg/RBR-5pckyr	<NULL>	Healthy volunteers; male gender; age between 18 to 35 years; eutrophic; physically active; non smokers; stable weight in the last six months; without any types of cardiorespiratory impairments and orthopedic limitations that could compromise the participation of this intervention.	Presence of planned surgeries during the study period; any use of medication or psychoactive substances; use of any type of dietary supplement or use of nutritional strategies such as the use of ergogenics; reluctance to sign the informed consent form; participation in another study; alcohol or drug abuse; frequency below 75% in interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-43dhh6	Behavior of parents/caregivers to control and manage childhood asthma: clinical trial with different technologies	Recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4194	The use of educational technologies to promote the self-efficacy of parents/caregivers for the management and control of childhood asthma	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-43dhh6	<NULL>	Parents/caregivers of at least one child from two to 12 years of age, with an established medical diagnosis of asthma and prescribed inhalation treatment, with or without the use of a spacer, who must be accompanied at the basic health unit, and have telephone contact. These must be at least 18 years of age.	Parents/caregivers with cognitive limitations that prevent them from participating in educational interventions or responding to research instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2xjprs	Pulmonary and movement description of patients who are treated by physiotherapy in a popular hospital	Not yet recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4195	Functional kinetic pneumatic profile of patients seen at a physiotherapy clinic in a public hospital	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Hospital Universitário Regional dos Campos Gerais	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2xjprs	<NULL>	Men and women in the age group above and / or equal to 18 years of age with a diagnosis of COPD and who accept to participate in the present study by signing the Informed Consent Form (ICF).	Major physical changes that impact the execution of the tests; people who do not have medical authorization to perform physical activities; pneumonia or flu patients; coughing up blood; unstable angina; recent acute myocardial infarction or after coronary graft surgery; acute congestive heart failure; severe aortic stenosis; recent eye surgery; severe and uncontrolled hypertensive crisis (BP = 170/100 mmHG at rest) and tachycardia&gt; 120 bpm at rest; thoracic aortic aneurysm; acute pulmonary edema; uncontrolled arrhythmias such as atrial fibrillation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-5vpyh4	Use of Anti-IL-17 in patients with Covid-19 associated pneumonia	Recruiting	Intervention	2020-07-06	<NULL>	<NULL>	4196	Use of Anti-IL-17 in patients with the severe acute respiratory syndrome (SARS) associated with Covid-19	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-08-28	Pesquisador	Novartis Biociência S.A.	https://ensaiosclinicos.gov.br/rg/RBR-5vpyh4	<NULL>	Adult patients (age &gt; 18 years); admitted to the Hospital Risoleta Tolentino Neves (HRTN) with SARS-CoV-2 infection confirmed by RT-PCR of oropharyngeal swab or tracheal aspirate; and evolve with fever (at least one measure &gt; 38º C in the last 24h) and severe acute respiratory syndrome (SARS) according to the Brazilian Ministry of Health definition (dyspnea / respiratory discomfort OR persistent chest pressure OR O2 saturation less than 95% in room air OR bluish coloration of the lips or face).	Functional classes III and IV of congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD); stages 4 and 5 of chronic kidney disease (GFR &lt;30 mL/min); diabetic ketoacidosis; known history of HIV/AIDS infection or chronic or acute HBV or HCV infection; uncontrolled bacterial or fungal co-infections (defined by hemodynamic instability, prior 48h of antimicrobial covering, or at the discretion of the study&apos;s medical coordinator); active tuberculosis (TB) infection; history of malignancy in the last year; current users (or in the last 15 days) of immunosuppressants (synthetic or biologic) or corticosteroids (in doses equivalent to or greater than 10mg of prednisone per day); neutrophils count &lt;1000/mm3; pregnancy or breastfeeding (pregnancy test will be performed during the screening period, before the inclusion, in all women of childbearing potential).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4nghh7	Longitudinal and retrospective study for dysmenorrhea therapy	Recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4197	Effect of kinesio taping, massage of connective tissue and tension on the symptoms of primary dysmenorrhea in young people	<NULL>	1-2, non-randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-01-10	Universidade Presbiteriana Mackenzie	Universidade Presbiteriana Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-4nghh7	<NULL>	Women with primary dysmenorrhea; presenting EVA at least 5; aged between 18 and 26 years; Normal BMI (18.5 - 24.9); without previous pelvic pathologies	Women with previous gynecological pathologies or previous surgeries; having undergone some type of treatment for primary dysmenorrhea; BMI out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-9nt4gj	Effect of chest compression techniques on the diaphragm of healthy children from zero to two years	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4198	Effect of different chest compression techniques on the diaphragm in healthy infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-18	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9nt4gj	<NULL>	The study included 22 healthy infants born at term (37 to 41 weeks) of both sexes, with at least 72 hours of life, this time was used respecting the safety criteria recommended by the I Brazilian Recommendation of Respiratory Therapy in Unit Pediatric and Neonatal Intensive Care	Infants born preterm, with congenital syndromes, upper or pulmonary airway malformations and central nervous system malformations, grade III or IV perintraventricular hemorrhage, peripheral nervous system injuries that interfere with the movement of the chest and the maintenance of the chest were excluded. airway opening, progressive neuromuscular disease, severe heart disease, congenital infectious disease, gastroesophageal reflux disease, chest or recent face trauma, respiratory disease with or without secretion up to two weeks prior to evaluation and incessant crying.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4jvybh	Effect of electric and magnetic brain stimulation on physical performance	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4199	Effect of transcranial direct current stimulation and transcranial magnetic stimulation on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4jvybh	<NULL>	Aged from 18 to 50 years; take part in physical training with competitive purposes during the last six months; participate in endurance competitions; free from any cardiovascular, musculoskeletal, neurological or psychiatric disease; not taking any medication that could affect the central nervous system (citalopram, amphetamines, L-dopa, sulpiride, pergolide, lorazepam, rivastigmine, flunarizine and carbamazepine); not having contraindications for tDCS (not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head)	Impossibility to analyze the data due to data loss; injury; voluntary abandonment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2nywjd	Comparison between two Hyaluronic Acid protocols for the treatment of TMJ Arthrosis.	Recruitment completed	Intervention	2020-09-01	<NULL>	<NULL>	4200	Therapeutical efficacy of two clinical protocols for Viscosuplementation of Temporomandibular joint in patients with Osteoarthritis	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia Universidade Federal do Rio de Janeiro	Faculdade de Odontologia Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2nywjd	<NULL>	It will be included individuals of both genders, literacy, over 18 years, presenting at least one of the following symptoms: unilateral or bilateral TMJ pain, occurring spontaneously and/or during mandibular function; presenting joint noises: crepitation or click, unilateral or bilateral; mouth opening limitation and articular pain during palpation of the TMJ, either unilateral or bilateral. All study subjects must meet the criteria of group III of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC-TMD). Each individual should have a CT scan showing one or more of the following changes: joint erosion, proven by loss of normal cortical bone design; sclerosis of parts or all of the condyle and/or joint eminence; flattening of joint surfaces; presence of osteophyte; presence of subchondral cysts.	Individuals who do not meet the inclusion criteria; history of TMJ surgery; volunteers with impaired verbal communication due to neurological disorder, previous disease sequelae or psychiatric condition; pregnant women; individuals taking osteoarthritis modifying medications such as condoitine, glucosamine or diacerin; illiterate individuals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-7yspdx	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue	Data analysis completed	Intervention	2020-08-13	<NULL>	<NULL>	4201	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue: A randomized crossover trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-08	Centro Universitário Euro-Americano	Centro Universitário Euro-Americano	https://ensaiosclinicos.gov.br/rg/RBR-7yspdx	<NULL>	Healthy young individuals aged 20 - 30 years selected from an existing database in our Extension Program.	History of recent infection (in the past 3 months), use of systemic cortiesteroids (in the last 3 months).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-3vc4d3	Effect of temperature and storage time off  bleaching agents.	Recruitment completed	Intervention	2020-09-01	<NULL>	<NULL>	4202	Effect of temperature and storage time on dental bleaching effectiveness and sensitivity: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3vc4d3	<NULL>	To be included in this study, males and females participants must be age 18 years or older and be in good general and oral health, healthy maxillary and mandibular anterior teeth, no cervical lesions, no white spot lesions or caries, and no periodontal disease.  The maxillary central incisors of each patient will be evaluated, specifically the médium third of the facial surface. These teeth must present color A2 or higher, according to the Vita scale (VITA Classic, Vita Zahnfabrik, Bad Sackingen, Germany) and Vita Easyshade (Vident,Brea, CA, USA).	The exclusion criteria were participants needing endodontic treatment or those with nonvital teeth,pregnant or breast-feeding women, participants with known allergies to bleaching materials or any other material used in this study, those taking antiinflammatory, analgesic or psychotropic drugs, the presence of restorations in the anterior teeth, parafunctional habits, those with severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth), those who smoked, and those who had undergone tooth-whitening procedures. During the first appointment, tooth sensitivity was measured using an air stream in the cervical region of the anterior teeth and vertical/horizontal percussion. Patients who demonstrated pain (on a verbal scale from 0 to 4) were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4dmnrr	Comparison of Bio Adhesive and Sutures in the Healing of the Palate after Graft Removal: randomized clinical trial	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4203	Comparison of Bio-Adhesive based on Cyanoacrylate and Conventional Sutures in Healing the Palate after Removing the Soft Tissue Graft: Randomized Clinical Trial	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2020-10-15	Centro de Ciências da Saúde (CCS)	Centro de Estudo e Pesquisa em implantes dentários (CEPID)	https://ensaiosclinicos.gov.br/rg/RBR-4dmnrr	<NULL>	"At least 18 years old- 70 years old;
Able to read and understand informed consent document;
Patients needing soft tissue graft with teeth that have miller class I or II recession, more equal 2mm, on the facial aspects;
Presence of periodontally healthy teeth at the recipient site equal or less than 25 percent plaque index;
Ability of the participants to maintain good oral hygiene;
Patient not pregnant or breastfeeding;
Not taking medications known to cause gingival enlargement;"	"Smokers/tobacco users;
Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing;
Patients that have severe gingival recession (Miller class III and IV) or less than 2 mm;
Presence of periodontal disease at the recipient site;
Poor oral hygiene;
Patient pregnant or breastfeeding;
Taking medications known to cause gingival enlargement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-54d3t3	Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Adjunctive Therapies	Data analysis completed	Intervention	2019-10-20	<NULL>	<NULL>	4204	Effects of Photobiomodulation and Antimicrobial Photodynamic Therapy Associated With Subepithelial Connective Tissue Graft on the Root Coverage of Multiple Gingival Recessions: A Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Odontologia de Bauru-Universidade de São Paulo	Faculdade de Odontologia de Bauru-Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-54d3t3	<NULL>	gingival recession in two or more adjacent teeth (multiple recession type defects); teeth witout root canal treatment; Patients without signals of periodontal disease and with plaque and gingival index in all mouth lesser than 20%; And patients that agree to the free and informed consent terms	Patients with systemic diseases that contraindicate surgical procedures or affect the course of healing; Patients who use medication that interferes with the healing process or who use anticonvulsant, antihypertensive or cyclosporine medications, or who have systemic diseases that pose a risk when performing surgical procedures; Smokers, pregnant women; Patients who have previously undergone periodontal surgery in the area of interest. And patients with orthodontic therapy in progression;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-8hr69v	Desprescribing benzodiazepine protocol.	Recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4205	Effect and feasibility of implementing a desprescribing benzodiazepine protocol.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de São João del-Rei	Universidade Federal de São João del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-8hr69v	<NULL>	"First stage: medical professionals, nurses and pharmacists with clinical and/or academic experience in the care of the elderly will be included. For analysis of the understanding of the content of the messages will be included seniors who are 60 years or older, who can read and who do not use benzodizepines;
Second and third stages: Elderly will be included from all units in the urban area of the municipality in chronic use of benzodiazepines for anxiety and insomnia, administered daily for at least three months, which were attended in one of the ESF."	Patients who use benzodiazepines for the treatment of epilepsy, psychiatric illness with a history of psychosis and alcohol and illegal drug addicts will be excluded; patients who are not cognitively competent, according to the mini-mental state examination - MEEM-23.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2x2czx	Influence of Smoking on Genetic Mutation, Color Change and Sensitivity after home tooth whitening: a clinical study	Not yet recruiting	Observational	2020-09-01	<NULL>	<NULL>	4206	Influence of Smoking on Genotoxicity, Color Change and Sensitivity after home tooth whitening: controlled clinical trial	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-30	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2x2czx	<NULL>	Volunteers aged between 18 and 54 years; nonsmokers or smokers; volunteers with teeth of color A2 or darker; presence of the 6 upper anterior teeth	Presence of erosion, abrasion or friction in the anterior teeth; volunteers who have undergone previous whitening treatment; presence of periodontitis; presence of dental caries; any systemic diseases; restorations in the upper anterior teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-72wx7w	Transcranial electrostimulation protocol in cases of interstitial cystitis	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4207	Transcranial direct current electrical stimulation in the treatment of interstitial cystitis: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-72wx7w	<NULL>	Women with interstitial cystitis diagnosed by a doctor according to the ESSIC criteria (diagnosis of neuropathic pain confirmed using the DN4 scale); age between 18 and 65 years; preserved intellectual and physical capacity to carry out the research tests; pain above 4 on the numerical pain scale.	History of seizures or epileptic illness, metallic implants in the head or neck, pregnancy, conditions associated with other pelvic diseases previously diagnosed as primary dysmenorrhea, endometriosis, diagnosis of urinary tract infection and patients with indication for hospitalization, age over 65 and age below 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4hsbjz	Behavior of parents and caregivers for the management and control of childhood Asthma: Clinical Trial with flipchart and Motivational Interview	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4208	Flipchart for Promoting the Self-Efficacy of parents and/or caregivers in the management and control of childhood Asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4hsbjz	<NULL>	Parents and/or caregivers of at least one child between 2 to 12 years old with an established medical diagnosis of asthma; prescribed inhalation treatment; with or without the use of a spacer; accompanied at the Primary Care Unit Health; have a cell phone or landline.	Parents and/or caregivers with apparent cognitive limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-9h4tp3	The impact on the quality of the ECG exam when performed outside the recommended standards	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	4209	Impact on ECG quality when electrodes are applied to incorrect intercostal spaces	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-26	Instituto Nacional de Cardiologia	Lorena Xavier Rocha Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-9h4tp3	<NULL>	"literate who can read and write; is that
hospitalized at the time of carrying out the research in the specific ward for treatment of coronary diseases of that institution; in pre and post-myocardial revascularization surgery operatives; with medical diagnosis of unstable angina; or acute myocardial infarction."	All patients with abnormalities of cardiac cavities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-3s7g4t	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4210	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3s7g4t	<NULL>	Age between 18 and 59 years old, Present persistent nonspecific low back pain	Pregnant women; Women in the postpartum period; Patients who use anticoagulant; Patients who have donated blood in the last 3 months; Anemia; Red flag patients (vertebral fracture; vertebral tumor; vertebral infection; equine tail syndrome; progressive neurological impairment); Systemic diseases (autoimmune; infectious; vascular insufficiency; renal insufficiency; hepatic insufficiency; neoplasia); Fibromyalgia; Lumbar disc herniation; Symptomatic irradiated pain (positive Laségue test); Anterior spine surgery; People with open and poorly healed wounds; Inflamed skin; Alteration of skin integrity; Open fractures; Previous experience of physical therapy treatment in the last 3 months; People who have had previous wind therapy treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-46rgjc	The learning curve in silicone ring around uterine cervix	Recruitment completed	Intervention	2020-09-02	<NULL>	<NULL>	4211	Comparative analysis between Cervical Pessary versus standard treatment in pregnancy with higher risk of Preterm Birth - evaluation of the learning curve	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-46rgjc	<NULL>	Pregnant women between 18th to 24th week of gestation with cervical length lower or equal 25 mm	Cervical cerclage in current pregnancy; Greater than 1 cm cervical dilatation; Painful uterine activity; Labor; Rupture of membranes; Protrusion of membranes in the gynecological examination; Active vaginal bleeding; Placenta previa; Severe hepatic disease; Cholestasis during pregnancy; Thromboembolic event during pregnancy; multiple pregnancies; Major fetal abnormalities; Fetal death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2s94rb	Messages sent via WhatsApp to analyze adherence to protection measures in the pandemic	Not yet recruiting	Intervention	2020-09-02	<NULL>	<NULL>	4212	Effectiveness of messages via WhatsApp® in adhering to the use of masks and social distance	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2s94rb	<NULL>	Have a cell phone and have internet access to use the Whatsapp® application; literate and ability to understand the Portuguese language and without visual and / or cognitive impairment	Individuals who express a desire to no longer participate in the study will be excluded; those who have lost or changed their phone number; those who are hospitalized or dying and / or those who refuse to participate in the interview to assess outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-33v2cd	Evaluation of the success of aesthetic treatment of teeth with a new ceramic	Recruiting	Intervention	2020-09-02	<NULL>	<NULL>	4213	Clinical performance evolution of ultra-thin translucent zirconia Veneers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Pós-Graduação em Saúde Coletiva da Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-33v2cd	<NULL>	"Patient with satisfactory oral hygiene, health periodontal and occlusal stability;
Patients with discoloration and poor tooth formation, or diastemas that generate dissatisfaction with the aesthetic condition."	Pregnant women and smokers; Patients with physical or mental weaknesses; Patients with uncontrolled parafunctional habits, orofacial pain, dental erosion or loss of vertical dimension of occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-6qvmjs	Research of scleral fixation technique of four-haptic intraocular lens using suture	Recruitment completed	Intervention	2020-09-02	<NULL>	<NULL>	4214	Scleral Fixation Using a Hydrophilic Four-haptic Lens and Polytetrafluoroethylene Suture: A Phase I Clinical Trial	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2019-02-11	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6qvmjs	<NULL>	Patients over 18 years old; aphakic or subluxated or dislocated IOL; absence of safe capsular support; corrected visual acuity better or equal to 5 letters for uncorrected acuity.	Patients with capsular support that made possible IOL implantation without scleral fixation; ocular comorbidities that could be aggravated by surgery; endothelial cell count less than 1000 cells and/or qualitative changes on specular microscopy as polymegatism and pleomorphism that, in the opinion of the investigator, were high risk for postoperative bulls keratopathy; systemic comorbidity that contraindicated the surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-68q84r	Acute effect of  electrical stimulation on Parkinsonian tremor inhibition	Not yet recruiting	Intervention	2020-09-03	<NULL>	<NULL>	4215	Acute effect of transcutaneous electrical stimulation on Parkinsonian tremor inhibition: A crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-68q84r	<NULL>	Volunteers with a proven diagnosis of Parkinson&apos;s Disease (PD); having hand tremors; having no associated diseases and accepting to participate in the research.	Volunteers with pacemakers; cardiac arrhythmias; pregnant women; metallic prosthesis in the area to be stimulated; uncontrolled hypertension; neoplasms; or any other contraindication for applying electric current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-65jtbm	Relationship of vagina muscle preparation during pregnancy and birth route on postpartum perineal muscle function: controlled clinical trial.	Recruitment completed	Intervention	2019-10-25	<NULL>	<NULL>	4216	Relationship of perineal massage and birth route on postpartum pelvic floor muscle function: controlled clinical trial.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-65jtbm	<NULL>	Primiparous women; over 18 years old; single-fetus pregnancy, a pregnant woman with usual risk pregnancy and who has not performed any preparation intervention for the pelvic floor muscles.	Pregnant women who have clinical and / or obstetric complications; with previous pelvic or vaginal surgery; presence of pelvic organ prolapses that extend beyond the vaginal introite; those with intolerance to vaginal palpation, inability to perform contraction of the pelvic floor muscles; acute or chronic vaginal infections; women with difficulty in understanding the proposed procedures; with motor / neurological deficit of the lower limbs and those who have already used prenatal methods of pelvic floor preparation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-6pq44p	Medical care by video calls in Parkinson&apos;s disease patients at Hospital Universitário Walter Cantidio- UFC	Recruiting	Intervention	2020-08-05	<NULL>	<NULL>	4217	Telehealth in Parkinson&apos;s Disease patients at Hospital Universitário Walter Cantidio- UFC	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-12	Faculdade de Medicina da  Universidade Federal do Ceará	Hospital Universitário Walter Cantidio	https://ensaiosclinicos.gov.br/rg/RBR-6pq44p	<NULL>	Diagnosis of Parkinson&apos;s disease according to the London Brain Bank diagnostic criteria; Being patient registered at the neurology outpatient clinic of the Hospital Universitário Walter Cantídio; Patient must have at least one face-to-face consultation record in the 12 months prior to the telehealth; Acceptance to participate in the telehealth appointment and in the study.	First consultation; Do not accept video call consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-6j3rqy	Modified stomach reduction surgery as a treatment option for patients with indication	Recruiting	Intervention	2020-09-03	<NULL>	<NULL>	4218	Roux-en-Y Gastric Bypass as a therapeutic option in patients with indication for Bariatric and / or Metabolic Surgery: clinical trial	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Geral de Goiânia - HGG	Hospital Geral de Goiânia - HGG	https://ensaiosclinicos.gov.br/rg/RBR-6j3rqy	<NULL>	Individuals of both sexes; Minimum age of 18 and maximum of 70 years for a BMI greater than or equal to 35 kg / m2; Age from 30 to 70 years for BMI greater than or equal to 30 and less than or equal to 34.9 kg / m2, associated with diabetes; Absence of contraindications for the surgical procedure.	Abandonment of pre-operative multiprofessional follow-up before 12 months; Members of vulnerable groups; Uncompensated psychiatric disorders or cognitive impairment confirmed by a psychiatrist and / or psychologist; Abuse of alcohol or illicit drugs confirmed after evaluation by the psychiatrist and / or psychologist; Chronic diseases not related to obesity such as cancer, pneumopathy, nephropathy, heart disease, Parkinson&apos;s and Alzheimer&apos;s. Patients already undergoing other bariatric surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-77nnpx	The importance of using good bacteria to improve the damage caused by excess abdominal fat	Recruitment completed	Intervention	2020-09-03	<NULL>	<NULL>	4219	Evaluation of the influence of Probiotic with multiple strains on inflammatory and metabolic markers in women with Central Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-77nnpx	<NULL>	Women; age over 18 years; waist larger than 80cm	Use of antibiotics; pregnant women; using anabolic steroids; diagnosis of chronic kidney disease, liver disease or neoplasia; with reduced cognitive ability; absence of signature of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-68xbth	Pulse oximeter evaluation in  the reading of tooth oxygenation	Data analysis completed	Intervention	2020-09-04	<NULL>	<NULL>	4220	Pulse oximeter evaluation in oxygen saturation reading of the dental pulp	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-18	Universidade Federal de Santa Catarina	Programa de Pós-Graduação em Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-68xbth	<NULL>	Healthy volunteers; non smokers; both genders; intact permanent teeth without cavities or restorations; teeth with pulp vitality without internal resorption or calcification; teeth with complete root apex without signs of periodontal or periapical lesions	Smoking patients; patients who suffered external tooth whitening; patients with parafunctional habits; patients with a history of dental trauma; pregnant women; lactating women; patients using orthodontic appliances; patients with previous dental pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2fvjjm	Hyperbaric Oxygen Therapy for hospitalized patients with Covid-19	Recruiting	Intervention	2020-08-11	<NULL>	<NULL>	4221	Multicenter, prospective, randomized, double-blind clinical trial for the use of Hyperbaric Oxygen Therapy in patients hospitalized with Covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-18	Universidade Federal de Minas Gerais	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2fvjjm	<NULL>	Both sexes; age above 18 years; presenting with one or more of the following symptoms of acute respiratory infection, such as anosmia and / or dysgeusia, cough, fever above 37.8ºC, dyspnoea, sore throat, coryza; confirmed diagnosis of the disease (SARS-Cov-2) in the last 5 days by one of the current tests (with approval from a state or national regulatory agency); pending laboratory test result (SARS-Cov-2), but patient with a high clinical suspicion for COVID-19 indicated by the mandatory observation of all the following items, cough lasting less than or equal to 10 days, pulmonary infiltrates in the chest image (simple chest X-ray or computed tomography), hypoxemia defined as SaO2 less than or equal to 94%, no alternative explanation for symptoms of acute respiratory infection, recent contact with persons with suspected COVID-19 or recent return from travel from a place with a high number of cases, computed tomography scan of the chest with suggestive changes, performed no more than 24 hours before admission.	Present an usual contraindication to hyperbaric therapy, including untreated pneumothorax, spherocytosis, recent middle ear surgery, sinusitis, doxorubicin use, bleomycin, disulfiram, cisplatin, mafenide, as well as topical use of iodine and petrolatum.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-3shhxs	"Effects of dietary intervention on toxicity and quality of life in patients with
Breast Cancer during chemotherapy treatment Neoadjuvant: randomized clinical trial"	Recruitment completed	Intervention	2018-11-12	<NULL>	<NULL>	4222	"Effects of dietary intervention on toxicity and quality of life in patients with
Breast Cancer during chemotherapy treatment Neoadjuvant: randomized clinical trial"	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal do Rio Grande do Norte - UFRN	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3shhxs	<NULL>	Adult volunteers; age between 20 and 59 years; with diagnosis of breast cancer; with clinical and cognitive conditions to participate in the study stages; have not started any specific type of oncological treatment; have indication for neoadjuvant chemotherapy treatment; nutritional risk; not being in nutritional outpatient follow-up and have recent computed tomography of total abdomen.	Volunteers who are already undergoing some kind of cancer treatment; with AIDS diagnosis; non-cancerous liver diseases; tuberculosis; neurological disorders; at nutritional risk and with computed tomography prior to 60 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-7jfm87	Inspiratory Muscle Training in Postoperative Period of Cardiac Surgery: Comparison between Manual and Automatic Loads	Recruiting	Intervention	2020-09-07	<NULL>	<NULL>	4223	Inspiratory Muscle Training in Postoperative Period of Cardiac Surgery: Comparison between Manual and Automatic Loads	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Fundação Universidade Federal de Mato Grosso do Sul	Fundação Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7jfm87	<NULL>	"Patients on the first postoperative day of cardiac surgery;
Age from 18 years;
Both sexes;
Hemodynamic stability."	"Refusal of the participant due to pain during training;
Paralysis or facial trauma that prevents the adaptation of the buccal;
Deficit in understanding the commands needed to perform the tests;
Intubated or tracheostomized patients;
Altered or lowered level of consciousness (with oscillations according to the Glasgow Coma Scale (ECG), between 8 and 12);
Under 18 years old."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-35vwq9	Telephone orientation on the health of elderly during COVID-19 pandemic	Recruiting	Observational	2020-09-07	<NULL>	<NULL>	4224	Impact of strutured telephone teleorientation on the health of elderly during the COVID-19 pandemic	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Centro de Referência do Idoso - CRI Norte	Centro de Referência do Idoso - CRI Norte	https://ensaiosclinicos.gov.br/rg/RBR-35vwq9	<NULL>	Both genders; aged 60-80 years; who received calls to call centers; accompanied by the following specialties: Endocrinology, Urology, Psychiatry, Geriatrics and Rheumatology. Ability to follow study procedures, including filling out necessary questionnaires or with help from family members, according to the researchers&apos; assessment. Provide informed consent, in accordance with the regulations of the Research Ethics Committee, in person or electronically.	Inability to complete the questionnaire even with the help of a companion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-3y32sh	The effect of laser treatment on reducing eye pressure and reducing eye drops in patients with Glaucoma	Recruitment completed	Intervention	2020-09-08	<NULL>	<NULL>	4225	Selective laser trabeculoplasty as initial therapy in patients with open-angle glaucoma and ocular hypertension. Assessment of effectiveness, safety and economic impact	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-08	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3y32sh	<NULL>	People with open-angle glaucoma or high-risk ocular hypertension; Mild to moderate glaucoma; 40 to 80 years of age; Patient being treated with topical hypotensive eye drops.	Advanced open-angle glaucoma; Glaucoma secondary to trauma and medication; In treatment for other ophthalmic diseases that require laser applications or treatment with intraocular injections; Previous incisional glaucoma surgery; Previous laser treatment for glaucoma; Presence of corneal opacity that prevents adequate vision of the trabecular meshwork; Intraocular inflammation in the last 3 months or previous surgery in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-6nv76g	Influence of bleaching agent application times on the effectiveness and safety of in-office tooth whitening	Recruitment completed	Intervention	2020-09-09	<NULL>	<NULL>	4226	Influence of 37.5% hydrogen peroxide application times on the effectiveness and safety of in-office tooth bleaching: a double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6nv76g	<NULL>	The six maxillary anterior teeth had to be present, with a shade mean C2 or darker; to be at least 18 years of age; the anterior maxillary and mandibular teeth should not have more than 1/6 of the buccal surface covered with a restorative material; to be with good dental and general health.	Individuals with or to be treated for active caries or periodontal diseases; with visible cracks in maxillary or mandibular anterior teeth; evident malocclusion or under orthodontic treatment; parafunctional habits; severe internal tooth discoloration (tetracycline, fluorosis or pulpless teeth); tooth sensitivity; previous bleaching treatment; smokers; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4scq8h	Periodontal problems in covid-positive but asymptomatic patients	Recruiting	Observational	2020-09-09	<NULL>	<NULL>	4227	Asymptomatic covid-positive patients and periodontal disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-09-07	Federico Henriquez y Carvajal University	Federico Henriquez y Carvajal University	https://ensaiosclinicos.gov.br/rg/RBR-4scq8h	<NULL>	Patients with PCR positive for Covid-19; Patients with no symptoms for Covid-19; Patients over 18; Patients without associated systemic pathology (patient ASA I).	Pregnant women; Smoking patients; Patients who do not want to be part of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5rb2ps	Effects of intensities of exercise combined on type 2 diabetic women in menopause	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4228	Effects of exercise intensity on metabolic, respiratory and cardiovascular parameters in type 2 diabetic women - a clinical randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Lavras	Financiamento Próprio	https://ensaiosclinicos.gov.br/rg/RBR-5rb2ps	<NULL>	Being a carrier of DM2; being in amenorrhea for at least 12 consecutive months; be able to exercise by Par-Q; being sedentary or not engaging in regular physical activity (not practicing a minimum of 150 minutes of physical exercise per week according to WHO criteria).	Use of hormone replacement therapy; smoking; presence of coronary artery disease or debilitating diseases; hysterectomized women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5r2rtb	Different types of strengthening in women with patellofemoral pain syndrome	Recruiting	Intervention	2019-02-28	<NULL>	<NULL>	4229	Influence of core muscles in women with Patellofemoral Pain Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-12	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5r2rtb	<NULL>	Pain at least for a month. No relation with accident. Insidious onset. Positive tests for patellofemoral pain. Female. Between 18 and 30 years old.	Specific diseases of the knee. Knee surgery. Knee treatments or physiotherapy during the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-6wghcx	Comparison of Pilates and Bodybuilding in Physical Fitness and Quality of Life in the Elderly of Brasília-DF	Data analysis completed	Intervention	2020-09-09	<NULL>	<NULL>	4230	Comparative Analysis of the Pilates Method and Resistance Training in Physical Fitness and Quality of Life of Elderly in Brasília-DF	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Centro Universitário Euro Americano	Centro Universitário Euro Americano	https://ensaiosclinicos.gov.br/rg/RBR-6wghcx	<NULL>	Elderly women aged 60 years or more, who had not been exercising regularly for at least 3 months.	Elderly women who practiced physical exercise regularly, who had some orthopedic condition that would disable the practice of the activities and elderly women with uncontrolled chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-6g87mn	Association between knee ligament injury and restricted hip movement	Recruitment completed	Observational	2020-09-09	<NULL>	<NULL>	4231	The association between ACL injury and restricted hip range of motion among athletes	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Santa Casa de Misericórdia de São Paulo	Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6g87mn	<NULL>	Athletes; volunteers; outpatients at sport trauma at Santa Casa de São Paulo	patients previously diagnosed with lower limb fracture; inflammatory disease; femoroacetabular impingement syndrome; hip dysplasia; lower limb dysmetria; histories of previous knee surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-77bg2m	Effect of consumption of native fruits on diabetic individuals	Recruitment completed	Intervention	2020-09-09	<NULL>	<NULL>	4232	Effect of consumption of red araçá pulps (Psidium cattleyanum Sabine) and Butiá (Butia capitata) on glycemic and lipid profiles and on oxidative stress markers in diabetic individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Universidade do Planalto Catarinense	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-77bg2m	<NULL>	This research will include patients over 18 years of age with DM2 who spontaneously want to participate in the study, signing the consent and clarification term (ICF). It is worth mentioning that at any time the selected individuals may abandon the research without prejudice to their treatments.	Patients using insulin; Patients unable to complete the questions as a result of linguistic difficulties, education or unable to attend the previously scheduled assessments; Patients who do not consume fruits of Araça or Butia Patients who have a BMI greater than 35 kg / m2 and have other concomitant health problems. Patients who do not feel comfortable with the research criteria and do not want to participate in the study or do not sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-7qt9sp	The effect of Dance Therapy on the psychological aspects of patients with breast cancer	Not yet recruiting	Intervention	2020-09-09	<NULL>	<NULL>	4233	The effectiveness of a Dance Therapy protocol on the psychological aspects of patients undergoing adjuvant treatment for Breast Cancer: the body beyond the disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7qt9sp	<NULL>	Women; age group older than 18 years; clinical stage I to III of breast cancer; be in adjuvant treatment with hormone therapy; be resident in the cities of Florianópolis or São José; present a release from the oncologist responsible for the practice of physical exercise.	Present some orthopedic or neurological limitation that prevents the practice of systematic physical activity; perform combined practice of any physical exercises in order to avoid confusion bias in the face of the intervention; having practiced dance therapy or free dance in the last three months; not be present in at least 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4pyjkq	Patient and ventilator mismatch in Noninvasive Ventilation during sleep in patients with Chronic Obstructive Pulmonary Disease	Data analysis completed	Observational	2020-09-10	<NULL>	<NULL>	4234	Patient ventilator asynchrony in sleep stages during Noninvasive Ventilation in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pyjkq	<NULL>	Adult patients; over 40 years old; diagnosed with COPD by spirometric criteria, classified as moderate or severe; with stable disease characterized by the absence of exacerbation for more than 2 months; with absence of other pulmonary, cardiovascular, renal and neurological morbidities; and who signed the informed consent form.	Patients who did not complete the study protocol; and who did not sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-7wvj2y	Effect of a new light and contrast mechanism on the detection of lesions in Endoscopic examination of the colon in Cancer screening procedures	Recruiting	Intervention	2020-09-10	<NULL>	<NULL>	4235	Effect of Linked Color Imaging on the detection of Adenomas in screening Colonoscopy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	carlos eduardo oliveira dos santos	Santa Casa de Caridade de Bagé	https://ensaiosclinicos.gov.br/rg/RBR-7wvj2y	<NULL>	both genders; age between 45 and 100 years; indication for colorectal cancer screening taking into account the guidelines of the American Cancer Society; adequate intestinal preparation; complete colonoscopy	symptomatic patients; age under 45 years; advanced colorectal cancer; use of antithrombotic medication; inflammatory bowel disease; previous colorectal surgery; presence of adenomas in previous colonoscopy that were not removed; acute lower gastrointestinal bleeding; inadequate bowel preparation; incomplete colonoscopy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5sfmz7	The effect of Respiratory Training in thoracoabdominal mobility and respiratory muscle in Heart Failure	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	4236	Analysis of the influence of Respiratory Training in thoracoabdominal efficiency and activation of respiratory muscles in Heart Failure a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-20	Fundação Universidade de Brasilia	Fundação Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5sfmz7	<NULL>	Subjects with heart failure NYHA II and III; with the same drug therapy in the last three months; able to participate in the intervention protocol	Subjects with decompensated heart failure; with previous lung disease; with neurological diseases or neurodegenerative diseases; presence of bronchial hypersecretion; and subjects which present difficulties of understanding and execution of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-3cbjq9	Effectiveness of Photobiomodulation in Sensitivity to tooth Whitening in adults: randomized clinical trial.	Data analysis completed	Intervention	2020-09-10	<NULL>	<NULL>	4237	Laser therapy applied for Sensitivity after tooth Whitening	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Universidade Federal do Amazonas - UFAM	Universidade Federal do Amazonas - UFAM	https://ensaiosclinicos.gov.br/rg/RBR-3cbjq9	<NULL>	At least canines with A2 or darker color and six superior anterior teeth free of restorations on the palatine and vestibular faces, healthy enamel and without pathological, physiological and drug alterations.	Volunteers with systemic diseases (metabolic, heart disease and immunological), oral condition with periodontal diseases. with orthodontic appliance, severe crowding, presence of intrinsic stains, using anti-inflammatory drugs, smokers, alcoholics, pregnant women or lactating women. Patients who reported strong or very strong sensitivity (scores from 3 to 4) of the 5-point Numerical Scale (NRS: 0 - no sensitivity, 1 - mild, 2 - moderate, 3 - strong and 4 - very strong) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4smhk6	Treatment for dry mouth sensation in patients after radiotherapy of head and neck	Recruiting	Intervention	2020-09-11	<NULL>	<NULL>	4238	Treatment for xerostomia in patients after head and neck radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-03	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP/USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-4smhk6	<NULL>	Men; Women; over 18 years old; history of oral cavity neoplasm treated with radiotherapy for more than 3 months and less than 2 years after termination	Sjogren&apos;s Syndrome; Graft versus Host Disease (GVHD); Hepatitis B and C; HIV; Sarcoidosis;  other diseases of the connecting tissues; physical or mental illness at the time of the examination;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5yjyr7	Effects of a dual-task aquatic and terrestrial physical exercise program on motor and cognitive functions of individuals with Parkinson&apos;s Disease - AquaDualPark study	Data analysis completed	Intervention	2020-09-11	<NULL>	<NULL>	4239	Parkinson&apos;s Disease and Physiotherapy: Analysis of the impact of intervention programs with terrestrial and aquatic physical activities - FisioPark	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Paraná	Prefeitura Municipal de Curitiba - Secretaria da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5yjyr7	<NULL>	Diagnosis of idiopathic Parkinson&apos;s disease; Be between stages 2 to 4 of the Hoehn &amp; Yahr scale; Agree to the Free and Informed Consent Form; Present medical certificate clearing to practice physical activity; Present medical certificate clearing to practice aquatic physical activity; Present independent march; Present visual, auditory and cognitive skills to follow verbal instructions during evaluations and interventions	Present changes in the dosage of Levodopa or other Parkinson-related medication during the research; Do not agree with the Informed Consent Form; Do not present a medical certificate clearing to participate in physical activity or for aquatic activity; Present physical or cognitive changes that prevent participation in evaluations and interventions; Do not carry out initial, intermediate and / or final evaluations; Present more than 75% of absences in the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-93wgtg	Electrical brain stimulation in children with Autism: Academicals skills and Social Cognition before and after intervention.	Other	Intervention	2020-09-11	<NULL>	<NULL>	4240	Transcranial direct current stimulation in children and adolescents with Autistic Spectrum Disorder: assessment of basic academic skills and social cognition before and after intervention	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de São Paulo	Centro Paulista de Neuropsicologia	https://ensaiosclinicos.gov.br/rg/RBR-93wgtg	<NULL>	Children and adolescent who have a diagnostic of Autism Spectrum Disorder according to DMS-5; age between 6 and 12 year; inserted on regular school environment; have degrees of understanding and collaboration compatible with carrying out the proposed activities; score more than 30 on the CARS scale.	Children with epilepsy; metallic implant in the brain or hearing aids; sensory or motor deficiencies that limit the performance of the procedures proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5xg4pk	"Influence of Motivational Interviewing on body measurements and consumption
diet of women with obesity"	Data analysis completed	Intervention	2020-09-11	<NULL>	<NULL>	4241	"Influence of Motivational Interviewing on anthropometric parameters and consumption
diet of women with obesity"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5xg4pk	<NULL>	Adult women aged between 18 and 61 years, all races, with a BMI between 30 and 40 kg/m²	Pregnancy, breastfeeding, inability  to read and interpret dietary prescription or fill food record,  use  of medications for weight reduction, antidepressants, antipsychotics, corticosteroids, lithium, previous diagnosed diabetes, uncontrolled psychiatric diseases, major psychiatric disorders, generalized anxiety, major depression, uncontrolled thyroid diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-7pmvs5	Consumption of nuts on metabolism and food intake in Overweight Subjects	Recruitment completed	Intervention	2018-04-30	<NULL>	<NULL>	4242	Acute effect of nuts beverage consumption on metabolism and food Ingestion in Overweight Subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-7pmvs5	<NULL>	The following inclusion criteria will be considered: men and women aged 19-59 years; body mass index (BMI) between 26 and 34.9 kg / m2; fat percentage&gt; 25% for men and&gt; 33% for women, absence of other chronic and acute diseases as well as eating disorders and allergies; do not make regular use of anti-inflammatory drugs, corticosteroids, antibiotics or that affect appetite and / or energy, lipid and glucose metabolism; have not had any infectious or allergic episodes in the last month; not being on diets for weight loss; stable weight in the last 3 months (fluctuation up to 5 kg); do not present aversion or allergy to cashew nuts and brazil nuts; no alcohol intake greater than 21 units (168g) per week; do not be a smoker.	Volunteers who do not follow the study protocol will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5ntdwg	Clinical Performance of regular resin composite with bioactive technology and resin-modified glass-ionomer in restorations of cervical lesions of Abfraction: a randomized controlled clinical trial	Not yet recruiting	Intervention	2020-09-11	<NULL>	<NULL>	4243	Clinical Perfomance of regular resin composite with S-PRG technology and resin-modified glass-ionomer in restorations of Cervical Lesions with predominance of Abfraction: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ntdwg	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4dr59v	Risk factors for caries lesion development and progressionin adolescents	Data analysis completed	Intervention	2020-09-14	<NULL>	<NULL>	4244	Incidence and Progression of Occlusal Caries in Adolescents - Risk Factors	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-07	Faculdade de Ciências da Saúde	Faculdade de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4dr59v	<NULL>	Students (10 to 16 years-old) with at least one permanent second molar partially erupted; students with permanent second molars erupted and in occlusion	Students with the permanent second molars partially erupted with sealants, fillings or cavities; students with the permanent second molars in occlusion with sealants, fillings or cavities;students with cronical diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-858zn7	Application of an educational action in pregnant adolescents on humanized delivery	Not yet recruiting	Intervention	2020-09-14	<NULL>	<NULL>	4245	Effects of an educational intervention for pregnant adolescents in the preparation for normal and humanized delivery	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-10-13	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858zn7	<NULL>	"Age between 14 and 19 years
Gestational age from 16 weeks;
Attend prenatal care regularly;
Have a smartphone for intervention with a mobile app"	"hearing and visual impairment;
Do not attend prenatal consultations on the scheduled days;
Gestational age above 28 weeks;
Pregnant women with indication for cesarean section known since prenatal care;
Premature birth"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4w8v93	Effect of blood flow restriction exercise on osteopenic women	Recruitment completed	Intervention	2020-09-14	<NULL>	<NULL>	4246	Chronic effects of strength exercise with blood flow restriction on bone metabolism biomarkers, strength and quality of life in osteopenic women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Comunitária da Região de Chapecó	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-4w8v93	<NULL>	Osteopenic Women	"Women under the age of 35 and over 99;
Men;
Recruits who have clinical restrictions for physical exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-25f7sc	Reduced tooth sensitivity using toothpastes with 8% arginine and low-power laser	Not yet recruiting	Intervention	2020-09-14	<NULL>	<NULL>	4247	Clinical evaluation on the effectiveness of reducing dental hypersensitivity in patients using 8% arginine-based dentifrices and a 320-360 nm laser. Parallel Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-20	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-25f7sc	<NULL>	"Individuals 18 to 75 years of age.
Both genders
Clinically healthy individuals
Availability to participate in the entire study
Sign the terms of free consent
Present hypersensitivity in non-adjacent teeth
Clear clinical presence of changes such as aberration, distress and erosion in anterior and / or molar teeth.
Response to the air jet stimulus for one second in the cervical region, as defined by the score 2 or 3 on the Schiff scale for sensitivity to the air stimulus.
Have good oral hygiene"	"Individuals with joys at the product being tested.
Individuals with clinical presence of pathologies recorded in the soft tissues.
Individuals undergoing chemotherapy and radiation therapy.
Individuals with gingivitis and / or periodontitis.
Individuals who will start taking anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory or analgesic drugs up to one month before the start of the study or who will start taking it during the study.
Individuals took antibiotics three months before the study.
Individuals participating in another study
Pregnant or breastfeeding women."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-3t5ts4	Development of Retinoic Acid Formulation for Acne	Recruitment completed	Intervention	2020-09-16	<NULL>	<NULL>	4248	Development of Retinoic Acid Formulation for Acne	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-09-03	Faculdade de Farmácia da Universidade Federal de Minas Gerais	Faculdade de Farmácia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3t5ts4	<NULL>	Healthy volunteers; both genders; age between 18 and 35 years	Present hypersensitivity to any of the components of the formulation; pregnant women; lactating; have skin burns, eczema or any other chronic skin disease; atopic individuals; present any metabolic disease; have any autoimmune disease; having had a vaccine up to two weeks before the start of the study or having the intention to have a vaccine while the study was being conducted; having already undergone chemotherapy treatment or being undergoing this type of treatment; making use of corticosteroid medications; make use of potentially photosensitizing drugs, such as thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides during the conduct of the experiment; individuals who are exposed to the intense sun frequently or who have been exposed to the intense sun in the last four months; individuals whose forearm skin has undergone procedures such as hair removal, chemical peels, dermabrasion or laser resurfacing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-5d4dj5	Group of patients admitted to the emergency department with COVID-19	Recruitment completed	Observational	2020-09-17	<NULL>	<NULL>	4249	Cohort study of patients at the emergency department with COVID-19 diagnosis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-14	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5d4dj5	<NULL>	Patients who arrive at the emergency department who are at least 18 years old; have suspected or confirmed SARS-CoV-2 infection; informed consent by the patient or the legal guardian.	No exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-2g9cf4	Evaluation of the photodymanic effect of methylene blue dilluted in detergent for the ancillary treatment of periodontal disease	Recruiting	Intervention	2020-07-02	<NULL>	<NULL>	4250	Evaluation of the photodymamic effect mediated by methylene blue in surfactant vehicle for the adjuvant treatment of periodontal disease: randomized, controlled and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Associação Educacional Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2g9cf4	<NULL>	Have stage III periodontitis, grade B; have at least 10 teeth present with probing depth greater than or equal to  5 mm; clinical attachment level greater than or equal to  5 mm; bleeding index to probing  less than  30%; minimum age of 18 years; both genders	Smokers; diabetics; patients with anemia; cancer; pregnant; antibiotic use in the last 6 months; anti-inflammatory use in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-5h432f	Effect of vitamin D3 supplementation on viral load and recovery of TCD4 + cells in HIV patients on antiretroviral therapy assisted by SUS	Recruitment completed	Intervention	2020-09-17	<NULL>	<NULL>	4251	Effect of vitamin D3 supplementation on viral load and recovery of TCD4 + cells in HIV patients on antiretroviral therapy assisted by SUS	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Piaui	FUNDAÇÃO DE AMPARO A PESQUISA DO PIAUÍ- FAPEPI	https://ensaiosclinicos.gov.br/rg/RBR-5h432f	<NULL>	being under treatment in Teresina; being aged 20 years; never having used ART; who are not using vitamin or mineral supplementation; who do not have a diagnosis of metabolic diseases,  diabetes, metabolic syndrome, thyroid disorders, bone diseases being treated, chronic renal failure, liver disease, gastric diseases or disabsorptive syndromes, neoplasms; pregnant and lactating women.	not complying with the proposed antiretroviral regimen or the placebo, supplement intake regimen during the six-month follow-up; pregnancy during follow-up; diagnosis of metabolic diseases, bone diseases being treated, chronic renal failure, liver disease, gastric diseases or disabsorptive syndromes, neoplasms during follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-52y5tq	Evaluation of the effectiveness of Adhesive Tissue in the skin and mucosa of Perineal Tears	Not yet recruiting	Intervention	2020-09-17	<NULL>	<NULL>	4252	Clinical trial on the use of surgical adhesive glue to repair first-degree perineal tears	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Thaís Trevisan Teixeira	Hospital Municipal Dr. Moysés Deutsch (M’Boi Mirim)	https://ensaiosclinicos.gov.br/rg/RBR-52y5tq	<NULL>	to have up to 6 centimetres of cervical dilation at the time the woman is invited to participate in the research; Do not use steroid substances; Do not present leucorrhoea or any signs of infection at the repair site; No diagnosis of diabetes mellitus; without history of allergy to surgical glue or formaldehyde; No difficulty in understanding the Portuguese language or in communication; Accept being submitted to perineal repair methods with skin adhesive or suture thread.	to have up to 6 centimetres of cervical dilation at the time the woman is invited to participate in the research; Do not use steroid substances; Do not present leucorrhoea or any signs of infection at the repair site; No diagnosis of diabetes mellitus; without history of allergy to surgical glue or formaldehyde; No difficulty in understanding the Portuguese language or in communication; Accept being submitted to perineal repair methods with skin adhesive or suture thread.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-7p4dtq	Influence of Argon Plasma Coagulation on weight loss in patients with weight regain after Stomach Reduction Surgery	Recruiting	Intervention	2020-09-17	<NULL>	<NULL>	4253	Influence of Argon Plasma Coagulation on weight loss in patients with weight regain after Bariatric Y Roux Surgery: Randomized clinical trial	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2020-02-07	Faculdade de Medicina de Botucatu	Mariana Bordinhon de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-7p4dtq	<NULL>	Individuals over 18 years of age with a history of regain weight of at least 10% of their weight after bariatric Y-Roux surgery performed for at least 18 months	Individuals with impossibility of endoscopic handling in the gastrointestinal tract; verification of anastomosis diameter less than 2.0 cm; severe organic pathologies, such as neoplasms, chronic obstructive pulmonary disease, renal failure, heart failure and cirrhosis; pregnancy or intention to become pregnant in the 12 months after the CPA procedure; inability to return to clinical care after the CPA procedure; and non-adherence to medical treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-973w9d	Effects of cranial sacral therapy associated with mobilization of the uterus to relieve menstrual cramps	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4254	Skull sacral and uterine mobilization to relieve primary dysmenorrhea	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-11	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-973w9d	<NULL>	Women enrolled in the higher education institution - FIS; Age between 20 and 28 years; Clinical diagnosis of dysmenorrhea in her pre-menstrual and menstrual period.	Amenorrhea; Alcoholism; Smoking; Pregnancy; Hysterectomy; Endometriosis; Polycystic ovary syndrome; Myoma; Ovarian cysts; Congenital malformations of the urinary tract; Cervical stenosis; Gynecological consultation for over a year; Make use of Intrauterine Device - IUD; Women using analgesic drugs or muscle relaxants; Women using any other therapy to treat primary dysmenorrhea and associated symptoms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-4ng2m8	Lumbar massage for pain reduction during labor in women from Serra Talhada / PE	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4255	Efficacy of lumbar massage for pain reduction during the first period of labor in parturients in Serra Talhada / PE	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-4ng2m8	<NULL>	Primiparae and multiparae in active dilation phase; with a single, full-term fetus; aged 15 to 30 years; without usual risk pregnancy: abnormal presentation, diabetes, hypertension, twin pregnancy.	Parturients with indication for cesarean section; all parturients who do not fit the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-6d73tn	Effects of two adhesive tapes for fixing the urinary catheter	Recruiting	Intervention	2020-09-18	<NULL>	<NULL>	4256	MARSI Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-08	Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6d73tn	<NULL>	Patients 18 years of age or older; using IUC; and absence of Medical Adhesive Related Skin Injury (MARSI)	Patients with absence of bilateral femoral pulse; cutaneous abnormalities in the regions of fixation of the indwelling urinary catheter (spots, scars, warts, lesions, irritations or abrasions); acute systemic dermatological diseases (such as Stevens-Johnson syndrome and toxical epidermal necrolysis); congenital dermatological diseases and those who express an express wish to discontinue participation or non-application of the tape for more than 24 hours uninterrupted	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-287dkz	Phase III clinical trial of superiority, randomized, multicentre, blind, parallel, to evaluate the efficacy and safety of Lisador® (Cosmed) compared to Novalgina® 500mg (Sanofi-Medley) in the treatment of postoperative pain in abdominal-pelvic videolaparoscopy	Not yet recruiting	Intervention	2019-02-04	<NULL>	<NULL>	4257	Phase III clinical trial of superiority, randomized, multicentre, blind, parallel, to evaluate the efficacy and safety of Lisador® (Cosmed) compared to Novalgina® 500mg (Sanofi-Medley) in the treatment of postoperative pain in abdominal-pelvic videolaparoscopy	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-01-20	Brainfarma Indústria Química e Farmacêutica S.A.	Brainfarma Indústria Química e Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-287dkz	<NULL>	"-Sign the TCLE; 
-Men and women, aged 18 or over;
-To present pain evaluation by the pain intensity scale: from 3,0 to 7,9 cm;
- Having undergone elective surgery by abdominal-pelvic videolaparoscopy, not due to malignancy;
- Schedule to be discharged within 24 hours of the end of the surgical procedure;"	"• Presence of infection associated with the condition, except for appendectomy;
• Surgery with indication for treatment of confirmed or suspected malignancy;
• Laparoscopic surgery that required conversion to open surgery;
• Use of opioids in the last 8 hours of signing the informed consent form;
• Chronic use of painkillers regularly for other reasons;
• Use of corticosteroids;
• Chronic use of any non-steroidal anti-inflammatory;
• Use of immunosuppressive therapy;
• Participants with a vomiting condition present at the time of signing the informed consent form;
• Presence of decompensated diabetes mellitus;
• History of decompensated obstructive or restrictive respiratory disease;
• History of blood dyscrasia or chronic disease of any nature that contraindicates the participation of the participant at the discretion of the investigator;
• Inability to understand and perform pain assessments in the study;
• Hypersensitivity or contraindication for use of the studied medication components;
•	Morbid obesity;
• Pregnant women;
• Present one or more flu-like symptoms such as: fever, cough, dyspnoea, myalgia and fatigue, respiratory symptoms, gastrointestinal symptoms (such as diarrhea) within 14 days prior to the screening visit;
• Participation in another clinical study in less than 1 year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-73gfct	Clinical trial to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of wisdom teeth extraction.	Not yet recruiting	Intervention	2019-02-12	<NULL>	<NULL>	4258	No inferiority Phase III clinical trial, randomized, multicentre, parallel and blind to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of third molar extraction.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-06-30	Brainfarma Indústria Química e Farmacêutica S.A.	Brainfarma Indústria Química e Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-73gfct	<NULL>	Sign the Informed Consent approved by the Ethics Committee,age greater than or equal 18 years old, participants of both sexes, have a third molar removal dental surgery in the last few hours and have a pain assessment on the VAS scale at least 50 mm.	Have used anti-inflammatories or analgesics of any nature in the last 48 hours; Have a history of peptic ulcer or gastrointestinal bleeding; Illness of any nature that contraindicates participation in the study; Is not able to understand and perform the pain assessments present in the study; Hypersensitivity or contraindication known to the medications or components of the medications studied; Pregnant or lactating women; Professionals and their relatives who are directly involved in the process during this study; Participation in another study in less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-4gdzh2	Home-based exercises for older adults in social isolation -STAGE 1	Recruiting	Intervention	2020-09-18	<NULL>	<NULL>	4259	Home-based exercises for oder adults: an alternative for social isolation period	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-24	Departamento de Educação Física da Universidade Federal do Paraná	Programa de Pós-Graduação em Educação Física- PPGEDF/UFPR	https://ensaiosclinicos.gov.br/rg/RBR-4gdzh2	<NULL>	Men and women; aged 60 years or over; who are independent in carrying out basic daily activities; who do not have absolute restrictions on the practice of physical activities.	Older adults with physical or motor limitations that make it impossible to perform functional tests; with a recent history of stroke; heart failure; those who use a pacemaker; who do not control unstable medical conditions (eg diabetes mellitus and hypertension); with neurological disease; with severe osteoporosis (with a history of two or more fractures); those who do not walk independently and need to use orthosis for locomotion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-523s66	Study of efficacy and safety of a new reusable device used in adrenal gland videosurgery	Recruiting	Intervention	2020-09-18	<NULL>	<NULL>	4260	Clinical validation of a new reusable balloon trocar for dissection in Retroperitoneoscopic Adrenalectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-04	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-523s66	<NULL>	Patients with adrenal tumors with indication for surgical removal after functional and image analysis, seen at the Clinical and Surgical Endocrinology outpatient clinic of Hospital Nossa Senhora da Conceição in Porto Alegre and discussed in a monthly multidisciplinary meeting Tumor Board.	Patients with BMI more than 35; patients with a history of pyelonephritis ipsilateral to the adrenal tumor; tumors greater than 6 cm; tumors with invasion of adjacent structures (vena cava, kidney, duodenum) suggestive of Adrenal carcinoma on Image examination (Tomography or Magnetic Resonance); patients with previous retroperitoneal surgery ipsilateral to the adrenal tumor or history of trauma; patients with contraindication or high risk for general anesthesia; Sonicision Ultrasonic Dissecting device (Covidien) malfunctioning in which it cannot be replaced or is not available.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-2xw4y3	Late complications after root coverage with two type of subepithelial connective tissue grafts	Recruitment completed	Intervention	2020-09-18	<NULL>	<NULL>	4261	Analysis of the treatment of multiple gingival recessions with subepithelial connective tissue graft harvested from the palatal area with predominance of the lamina propria or with predominance of submucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Bauru School of dentistry-University of São Paulo	Bauru School of dentistry-University of São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xw4y3	<NULL>	gingival recession in two or more adjacent teeth (multiple recession type defects); teeth witout root canal treatment; Patients without signals of periodontal disease and with plaque and gingival index in all mouth lesser than 20%; And patients that agree to the free and informed consent terms	atients with systemic diseases that contraindicate surgical procedures or affect the course of healing; Patients who use medication that interferes with the healing process or who use anticonvulsant, antihypertensive or cyclosporine medications, or who have systemic diseases that pose a risk when performing surgical procedures; Smokers, pregnant women; Patients who have previously undergone periodontal surgery in the area of interest. And patients with orthodontic therapy in progression;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-72fpz2	General anesthesia compared to spinal anesthesia in patients undergoing vascular surgery on the legs: effects on the frequency of respiratory complications after surgery	Recruiting	Intervention	2020-09-18	<NULL>	<NULL>	4262	General versus regional anesthesia in peripheral arterial surgery: effects on the incidence of postoperative pulmonary complications	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-28	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-72fpz2	<NULL>	Adult patients ASA II to IV; age greater than 18 years; scheduled for arterial revascularization surgery on lower limbs.	Patients with body mass index above 40 kg/m2; patients undergoing emergency surgery; history of pulmonary surgery; persistent hemodynamic instability in the preoperative period; history of asthma or chronic use of corticotherapy; history of neuromuscular disorder; history of use of anticoagulants or antiplatelet agents in the preoperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-554pws	Use of the Healthy Lifestyle Deck of cards in Therapy for Adults with Obesity	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4263	Healthy lifestyle deck of cards as a tool of Cognitive-behavioral group therapy of Obese adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	UNIFESP	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-554pws	<NULL>	volunteers between 30 and 60 years old; both genders; BMI between 30 and 39.99	bariatric surgery; participation in previous research by the Obesity Study Group (UNIFESP)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-95yjmq	Placebo-controlled clinical trial to evaluate the efficacy and safety of hydroxychloroquine and azithromycin in relation to placebo in the negative viral load of participants with SARS-CoV2 flu syndrome and who do not have an indication for hospitalization	Recruitment completed	Intervention	2020-04-29	<NULL>	<NULL>	4264	Randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of hydroxychloroquine and azithromycin versus placebo in the negative viral load of participants with flu syndrome caused by SARS-CoV2 and who have no indication for hospitalization	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-04-11	Hospital Santa Paula	Hospital Santa Paula	https://ensaiosclinicos.gov.br/rg/RBR-95yjmq	<NULL>	"Inclusion criteria
Age 18 and 65 years;
Flu syndrome for 48-120 hours characterized by the presence of at least two of the following: fever (may be absent), fatigue, cough (dry or productive), anorexia, malaise, muscle pain, sore throat, dyspnea, congestion nasal, anosmia, headache, diarrhea, nausea and vomiting. If the patient has pneumonia without signs of severity and without the need for supplemental oxygen, he will be eligible;
Infection with the SARS-CoV2 virus (COVID19), confirmed by a qualitative molecular test on nasopharyngeal and oropharyngeal swab samples;
Patients with no clinical indication for hospitalization;
Consent, voluntarily, to participate in the study by signing the Informed Consent Form (ICF)."	"Exclusion criteria
History of allergy or hypersensitivity to hydroxychloroquine, azithromycin, or any other component of the study drugs;
Any other condition that contraindicates the use of hydroxychloroquine, including ocular retinopathy, G6PD deficiency, prolonged QTc;
History of any lung disease including, but not limited to: chronic obstructive pulmonary disease (COPD), asthma, structural lung diseases; pulmonary fibrosis;
Immunosuppressed patients, whether due to pre-existing diseases or through the use of immunosuppressive treatment;
Patients with any malignancy;
History of any neurological event, including seizure, stroke, TIA and others;
History of cardiopathies or cardiovascular diseases, including severe arterial hypertension (defined by systolic pressure 160mmHg and / or diastolic pressure 100mgHg), atrial fibrillation, AMI, VTE, cardiac arrhythmias and others;
Prolonged Qt interval (Qtc greater than 480ms), evidenced by the ECG at the time of inclusion in the study;
Altered values ??of creatine phosphokinase (CPK): 5x above LSN
Altered values ??for lactic dehydrogenase (LDH): greater than 1000U / L
Insulin dependent diabetic patients;
Patients with renal failure defined by creatinine clearance less than 50mL / min calculated by the Cockcroft-Gault formula
Patients with significant hematological changes, defined by: anemia (hemoglobin less than 10g / dL), thrombocytopenia (platelets less than 100,000 / mm3), or leukopenia (leukocytes less than 2,000 / mm3)
Patients with TGO or TGP values ??2.5x above ULN or altered prothrombin time (INR above 1.5);
Patients with lower D-dimer3g / L at the time of inclusion in the study;
Patients already using hydroxychloroquine and its derivatives and / or azithromycin at the time of inclusion in the study;
Patients using antiretrovirals;
Patients participating in any clinical study, in the last 6 months until the moment of inclusion in the study;
Pregnant or breastfeeding women. For all women of childbearing potential who are able to become pregnant, a quantitative test will be performed at the screening visit to evaluate hCG in a blood sample to rule out pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-3gzsnn	Acute effect of Whole-body electrostimulation on cardiovascular and oxygen responses during exercise in obese individuals	Data analysis completed	Intervention	2020-09-20	<NULL>	<NULL>	4265	Acute effect oh Whole-body electromyostimulation on autonomic heart modulation and capacity cardiopulmonary in individuals with obesity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3gzsnn	<NULL>	Male volunteers; aged between 18 and 40 years; body mass index (BMI) higher than 30 kg/m² were considered obese; BMI between 18.5 to 24.9 kg/m² were considered eutrophic	Smoking volunteers; users of illicit drugs that influence the autonomic nervous system; hypertensive; diabetics; or other cardiorespiratory diseases; history of alcoholism; medication users who could alter the autonomic nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-27xb3b	Effect of restriction pressure on perceptual, metabolic and neuromuscular responses	Not yet recruiting	Intervention	2020-09-20	<NULL>	<NULL>	4266	Analysis of perceptual, metabolic and neuromuscular responses in resistance exercises with different levels of blood flow restriction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-27xb3b	<NULL>	Resistance training practitioners; healthy; male gender; age between 18 and 30 years; osteomioarticular lesions free in lower limbs.	Use of anabolic steroids; use of food supplements with ergogenic potential; inability to perform the knee extension and jump exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-39jnyj	Effect of bleaching with activated carbon on enamel	Recruiting	Intervention	2020-09-21	<NULL>	<NULL>	4267	Effectiveness, sensitivity and action on the enamel surface of activated carbon as bleaching agent: clinical and in situ study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39jnyj	<NULL>	Volunteers between 18 and 25 years old; both sexes; good oral and general health; vital teeth with color starting at A2; superior first molar with clinical crown greater than 5 mm, third molars extracted for orthodontic indication; vital	Have previous bleaching; smoker; tetracycline stains; fluorosis; hypoplasia; cracks; caries lesions; non carious lesions; periodontal disease; parafunctional habits; sensitivity; resin restorations in the anterior region; fixed or removable orthodontic appliance; third molars with morphological defects; cracks, fractures, caries lesions, non carious lesions and restorations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-8c7267	Benefits of functional training in women with knee pain.	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	4268	Effect of neuromuscular training and strengthening of the lower limbs musculature in women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-28	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8c7267	<NULL>	"Subjects must sign the Free and Informed Consent Form before starting the study activities; Aged between 18 and 30 years; 
Active womens, who perform any physical activity up to twice a week; Presence of anterior or retropatellar pain in the knee for at least the last 3 months in two or more of the following activities: running, walking, jumping, climbing and/or descending stairs while remaining seated or kneeling for an extended period of time, Squatting position during the isometric extension of the knee with 60º of flexion, and/or during palpation of the medial or lateral facet of the patella; Presence of dynamic valgus during the unipodal squatting."	Will be excluded, individuals submitted to recent physiotherapeutic treatment; With history of knee surgery; Patellar instability; Ankle or hip injuries; Meniscal or ligament injury; Joint swelling of the knee, or any other specific knee change; Tendinitis in the lower extremity; Low back pain; Pain in the sacroiliac joints; pregnancy; Presence of any neurological disorders / disorders that compromise the understanding of the procedure, or that affect motor control; Any cardiovascular changes and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-8d3qqn	Immersive virtual reality as an auxiliary resource in fitness training in young adults	Recruitment completed	Intervention	2020-09-21	<NULL>	<NULL>	4269	Implementation of immersive virtual reality as an auxiliary resource in the physical conditioning training of sedentary university students: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Financiamento próprio	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-8d3qqn	<NULL>	Young sedentary university students for at least six months, of both sexes, aged between 18 and 29 years.	Youth with inability to understand and respond to simple verbal commands; with heart disease; that make use of auxiliary devices for walking; with severe visual impairment or not compensated for the use of corrective lenses; with orthopedic disorders that result in movement limitation and use of prostheses in lower limbs; and who have performed physical activity regularly in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-3xmkyy	Neurostimulation and memory training in depression	Terminated	Intervention	2020-09-22	<NULL>	<NULL>	4270	Investigations on the recall of autobiographical memories and emotional regulation strategies in a clinical sample	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3xmkyy	<NULL>	Volunteers aged 18 to 50 years old, regardless of gender; presenting symptoms of moderate to severe depression by BDI; not being pregnant; not having metallic or electronic devices implanted in the head; not having a history of alcohol or drug abuse in the last 6 months; not using carbamazepine in the last 6 months; not having a history of epilepsy, stroke, moderate severe traumatic brain injury, or migraine; not having undergone neurosurgery; not having schizophrenia or bipolar disorder.	A fault during the treatment sessions, during the research;meet any of the aforementioned inclusion criteria, as in the case of women, becoming pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-9rnkbs	Effectiveness of an equipment to reduce the dispersion of particles in emergency dental care during the Covid-19 pandemic	Recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4271	Effectiveness of three prototypes of a device to reduce aerolization dispersion in emergency dental care in times of SARS-CoV-2 pandemic: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Pontifícia Universidade Católica do Rio Grande do Sul	Brigada Militar do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9rnkbs	<NULL>	Age over 18, of any sex; Need for emergency dental consultation with indication of procedures that require the use of high-speed turbines and / or ultrasound tips; Written consent to participate voluntarily in the study, upon signing the Informed Consent Form (ICF).	Age below 18 years; Need for emergency dental consultation without indicating procedures that require the use of high-speed turbines and / or ultrasound tips; Use of antibiotic medication in the last six months; Any systemic condition that requires the use of prophylactic antibiotic medication prior to dental consultation (eg, mitral valve prolapse with regurgitation); Presence of signs and symptoms compatible with acute respiratory syndrome, such as difficulty in breathing and fever (temperature&gt; 38oC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-4yr9mt	Evaluation of the effects of oxytocin in patients with schizophrenia	Not yet recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4272	Evaluation of the effects of oxytocin in patients with schizophrenia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-01	Faculdade de Medicina de Ribeirão Preto	Flávia de Lima Osório	https://ensaiosclinicos.gov.br/rg/RBR-4yr9mt	<NULL>	"General: Men aged 18 to 50 years, literate, signing the Informed Consent Form.
For the clinical group, the participants must have a diagnosis of Refractory Schizophrenia, with a disease duration between 10 and 15 years, be on an outpatient treatment, using Clozapine exclusively and without psychiatric comorbidities.
For the control group, participants must have no current or previous psychiatric disorder and use any psychotropic drugs. For Phase 3 of the study, participants in the control group must be overweight (BMI  greater than 25kg / m2)."	"For clinical and control group: presence of clinical diseases of great impact on the functioning of the organism, such as degenerative, neurological diseases, cancers, hematological, pulmonary, renal, liver, cardiovascular diseases and / or use of psychoactive substances.
For Phase 3: participants using oral antidiabetics, lipid-lowering drugs, sibutramine, amphetamines, orlistat or other medications for the treatment of excess weight will also be excluded. Participants with schizophrenia who experience any change in their medication or therapeutic prescriptions during the period of participation in the study will be automatically excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-373nm7	Assessment of pain and side effects between industrialized ointment with Lidocaine and manipulated Lidocaine ointment with Tetracaine for Hair Removal with Laser LightSheer®	Recruitment completed	Intervention	2020-09-22	<NULL>	<NULL>	4273	Antalgic and adverse effects of the industrialized topical formulation of Lidocaine 4 compared to the manipulated formulation of Lidocaine 23 associated with Tetracaine 7 in patients referred for Laser Hair Removal Lightsheer®	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-05-11	Clínica Dermatológica Dra Luciena Ortigosa	Clínica Dermatológica Dra Luciena Ortigosa	https://ensaiosclinicos.gov.br/rg/RBR-373nm7	<NULL>	Patients with a desire for epilation; Patients with pigmented hair in axilla, face, legs or groin; Both sexes; Age between 12 and 90 years	Patients with a history of allergic reaction to lidocaine or tetracaine; Patients with keloid; Sun exposure in the four weeks prior to the laser procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-23r5mc	"The use of gabapentin in the treatment of
keratoconus"	Data analysis completed	Intervention	2020-09-22	<NULL>	<NULL>	4274	The use of gabapentin in the management of postoperative pain in Crosslinking	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade do Oeste de Santa Catarina	Universidade do Oeste de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-23r5mc	<NULL>	Twelve participants with progressive keratoconus who underwent Crosslinking were selected, of both sexes, aged 10 to 40 years.	"Intellectual inability to answer the questionnaire applied in the postoperative period.
Allergy to the drug Gabapentin."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-3yn9nz	Effects of functional electrical stimulation of the thigh in patients undergoing cardiac surgery	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	4275	Effects of Functional Electrical Stimulation of quadriceps in patients undergoing coronary artery bypass grafting and valve replacement	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3yn9nz	<NULL>	Patients in the postoperative period of valve replacement surgery or myocardial revascularization; Age range between 30 and 80 years; Patients of both sexes; Patients stable from the hemodynamic and neurological points of view; No elevated pulmonary vascular resistance; Signature of the Term of Free and Informed Consent (TCLE) by the legal guardian.	Present peripheral nervous injury; Present heart pacemaker; Present quadriceps area with altered sensitivity; Refractoriness to electrical stimulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-9nrxdf	Effect of coffee with milk on cycling post training recovery	Recruitment completed	Intervention	2020-03-02	<NULL>	<NULL>	4276	Effect of coffee with milk on pathways of glycemic utilization and muscle glycogen recovery after cycling training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9nrxdf	<NULL>	Male adults; cyclists or triathletes. Stable body weight; healthy; regular coffee and milk drinkers. At least recreational trained according to the adapted classification of De Pauw et al. (2013).	Daily caffeine intake greater than 500 mg; athletes with any specific medical condition or recent injury; smokers; illicit drug users; drug treatment. Allergy; intolerance or discomfort with the consumption of milk and dairy products. Athletes who did not agree with the explicit informed consent form (ICF) during the interview could not be selected either.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-563h29	Effect of Massage Associated with Lavender Essential Oil on the Behavioral Context of Obese Women	Recruitment completed	Intervention	2020-09-23	<NULL>	<NULL>	4277	Effect of hot stone massage associated with lavender essential oil in the behavioral context of obese women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Franciscana	Universidade Franciscana	https://ensaiosclinicos.gov.br/rg/RBR-563h29	<NULL>	Be woman; between 20 and 60 years of age; sedentary; presenting obesity with a BMI between 30 and 45 kg / m²; not using psychotropic drugs	Women who are using psychiatric drugs; psychological monitoring at the time of the evaluation; those who have an aversion to lavender essential oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-7cz4sf	Effect of motor and cognitive training of the elderly in relation to the ability to perform daily tasks	Data analysis completed	Intervention	2020-09-23	<NULL>	<NULL>	4278	Effect of Motor-cognitive training (dual task) on the functionality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7cz4sf	<NULL>	Independent participants in the execution of the march; classified in stages 2 and 3 on the Hoehn and Yahr&apos;s Disability Scale; have preserved capacity for recognizing shapes and numbers; be able to sequence shapes and numbers proposed by the intervention	Participants who needed any kind of assistance to carry out the march; carriers of diseases that would prevent testing; those who were undergoing physiotherapeutic treatment or who were in a long-term institution	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-5ynppq	Study of the effect of serial casting on children with disabilities	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4279	"The use of serial casting in the treatment of children with
Cerebral Palsy"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ynppq	<NULL>	Children aged 3 to 10 with a diagnosis of Cerebral Palsy levels GMFCS I, II and III who are able to understand simple commands and who are able to understand the virtual game previously presented; individuals who are in attendance at Therapies and other clinics and / or institutions, disregarding the physiotherapy sessions performed by each child; Children who have not undergone bone surgery and / or arthrodesis; have not applied botulinum toxin or serial plaster in the past six months; who have not undergone muscle-tendon surgeries in the past year and have not undergone intensive treatment during the application of serial plaster; All participants must have a free and informed consent form signed by the legal guardian. In addition to the informed consent form signed by the child.	Children who present pain with the use of plaster cast, allergy to the material, medical complications or abandonment of the protocol are excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-44cs34	Sterile versus procedure glove in reducing blood culture contamination rates	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4280	Blood culture collection: sterile versus procedure glove	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-44cs34	<NULL>	Patients aged 18 years or older; admitted to the ICUs of the studied hospitals and with a medical request for blood culture collection will be included	Patients who present any contraindications to the collection of biological material and those whose collectors are unable to access the vascular system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-4qdjk6	Quantification of neuropathic pain in people with diabetes and physiotherapy treatment in the city of São João da Boa Vista-SP	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4281	Prevalence of neuropathic pain in individuals with type II Diabetes Mellitus and physical therapy intervention in the city of São João da Boa Vista-SP	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-08-03	Daniella Silva Oggiam	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qdjk6	<NULL>	"Residents, domiciled and registered in the municipal public network (UBSs and
PSFs) of São João da Boa Vista / SP;  Cognitive conditions to participate in the study (alert individuals,
mental ability to fulfill the study requirements voluntarily); Age over 30 years old, Both sexes;  Diagnosis of DM2 for 5 years or more;  Diabetic Neuropathy screening performed through the MNSI Instrument;  Presence of neuropathic pain diagnosed by LANNS scales and DN4"	"Alcoholism;  Decompensated hypothyroidism;  Signs of spinal compression, stenosis or radiculopathy;  Chronic pains of another nature such as: pain vascular and nociceptive pain;  Severe peripheral arterial disease;  Association of stroke ischemic or hemorrhagic with DM2;  uncontrolled arterial hypertension; pregnancy and lactation;  disease malignant disease in the lower limbs;  active systemic cancer;  posterior knee and / or spine surgery; Score greater than 12 on the Hamilton Depression scale (ANNEX IV);  Lack of blood glucose monitoring; Lack of dosage of glycated hemoglobin in the last 6 months; - Decline in free and informed consent
enlightened."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-7z5c63	Effect of electrical stimulation on muscle and its result on inflammation, muscle mass and function in cancer patients	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4282	Effect of neuromuscular electric stimulation on inflammation, mass and muscular function in patients with cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Tatyanne Letícia	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7z5c63	<NULL>	Cancer patients; both sexes; age over 18 years; admitted to a hospital during the study period.	Serious heart disease; exclusive palliative care; the presence of metallic implants in the region where the electrical stimulus is applied; practice of physical activity in the last six months; amputees; presence of epidermal lesion in the lower limbs; cognitive impairment and expected discharge from hospital less than 14 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-3dky3p	Effect of Bach flower remedies in stress relief  in nursing students	Recruiting	Intervention	2020-09-23	<NULL>	<NULL>	4283	Effect of flower remedies in reduction of stress in nursing students	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-08-13	Escola de Enfermagem da Universidade de São paulo	Escola de Enfermagem da Universidade de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dky3p	<NULL>	Undergraduate nursing students; Baccaro Test score above 20 points.	Students using complementary practice (acupuncture, auriculotherapy, reiki, among others), herbal medicine, antidepressive or anxiolytic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-8h7dmq	Study of the analgesic effect of the medication Allopurinol compared to placebo in patients with Fibromyalgia	Data analysis completed	Intervention	2020-09-23	<NULL>	<NULL>	4284	Study of the analgesic effect of Allopurinol versus Placebo in patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-14	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8h7dmq	<NULL>	Female gender; age between 18 and 65 years; functional status class I or II according to the American Society of Anesthesiologists (ASA); patients with fibromyalgia	Previous diagnosis of schizophrenia and other psychotic disorders; history of bipolar disorder; diagnosis of delirium; history of stroke; previous diagnosis of CNS neoplasia; deficit in cognitive or motor development; patients with dialysis renal failure; patients with gout or lithiasic kidney disease; patients who do not understand the Portuguese language or who are illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-6nvz9j	Hydrotherapy in blind people	Recruitment completed	Intervention	2020-06-23	<NULL>	<NULL>	4285	The aquatic physiotherapy on visual impairment	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-09	Universidade Federal do Triângulo Mineiro	Comitê de ética e pesquisa da Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6nvz9j	<NULL>	Volunteers with visual impairment either in whole or in part; age between 18 and 59 years; having link with ICBC; other than hypertension; don&apos;t have neuromusculoskeletal diseases that impair physical function; not have cutaneous lesions, severe kidney disease or allergy to pool cleaning products.	The no-show by more than 2 activities as evaluations and interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-97nt6j	Multicenter Study of the Integrative and Complementary Practice of the Use of Ozone Gas in Outpatients with Covid-19	Not yet recruiting	Intervention	2020-09-24	<NULL>	<NULL>	4286	Estudo Multicentrico da prática Integrativa e complementar de Ozonioterapia em pacientes ambulatoriais com Covid- 19	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-09-25	Associação Brasileira de Ozonioterapia	Associação Brasileira de Ozonioterapia	https://ensaiosclinicos.gov.br/rg/RBR-97nt6j	<NULL>	"Man and women 
Age between 18 and 90 years;
Signature of the informed consent form (ICF).
COVID-19 positive PCR (Swab) exam"	"Pregnancy, especially in the beginning;
Individuals who continuously use immunosuppressants or have been transplanted for less than 6 months;
Individuals participating in other clinical studies.
Symptoms of severe acute respiratory syndrome (SARS) and / or comorbidities according to the regulations of the Ministry of Health (Guidelines for Diagnosis and Treatment for COVID-19, version 1 of April 6, 2020), with suspicion of COVID-19, with Covid RT-PCR -19"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-6mk8r3	A Program of Health Promotion and Prevention of Damage on Pelvic Floor in Public Workers	Data analysis completed	Observational	2020-09-24	<NULL>	<NULL>	4287	A Program of Health Promotion and Prevention of damage on pelvic floor  in public workers of a brazilian public University	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-20	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6mk8r3	<NULL>	The inclusion criteria (IC) will be women between 20 and 60 years old; public workers of university and who aim to participate.	The exclusion criteria (EC) will be women who have some deslocation issue that interfere from going and / or carrying out the activities of the interventions; women who are already doing medical treatment, physical therapy or any other treatment directed to the pelvic floor dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-8rvrb5	Chlorella supplementation produces anti-inflammatory activity and improves quality of life in pre-diabetic and diabetic patients	Data analysis completed	Intervention	2020-09-24	<NULL>	<NULL>	4288	Modulating activity of the alga Chlorella in glucose intolerant and type-2 diabetic patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Hemocentro Universidade Estadual de Campinas	Hemocentro Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8rvrb5	<NULL>	Healthy, pre-diabetic or diabetic volunteers, attended at CECOM of UNICAMP; both genders; age between 18 and 75 years; continue with their therapeutic treatment; signed informed consent form.	History of drug or alcohol abuse; diagnosis of type 1 diabetes; decompensated blood pressure; diagnoses of severe psychiatric, renal, cardiac, pulmonary, autoimmune diseases, cancer and immunodeficiencies; pregnancy and lactation; hypersensitivity to iodine; use of immunosuppressants and warfarin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-2dxshp	The Safety and Efficacy of Target-Controlled Infusion versus Intermittent Bolus of propofol for Sedation on Colonoscopy: A Controlled Randomized Study	Recruiting	Intervention	2017-10-05	<NULL>	<NULL>	4289	The Safety and Efficacy of Target-Controlled Infusion versus Intermittent Bolus of propofol for Sedation on Colonoscopy: A Controlled Randomized Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-16	Associação Matogrossense de Combate ao Câncer	Hospital de Cãncer de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-2dxshp	<NULL>	Patients with Physical Status I and II according American Society of Anesthesiologists ( ASA ); undergoing colonoscopy; aged 18 to 65 years; both gender and Body Mass Index ( BMI ) less than 30; accept to sign the Informed Consent	Patients with a history of allergy to any of the medicines; Body Mass Index greater than 30; refusal to sign the informed conset	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-358597	Spirituality, personality, mood, and their influence over clinical outcomes of hospitalized patients	Recruiting	Observational	2019-03-15	<NULL>	<NULL>	4290	Spirituality, personality and mood as markers of clinical outcomes: a longitudinal study of the subjective dynamics of inpatients and healthcare professionals in the hospital setting	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-358597	<NULL>	Patients admitted at Hospital Sao Paulo, Universidade Federal de Sao Paulo with their respective physicians	Altered level of awareness; severe psychiatric or neurological disorders; hemodinamic instability; or other conditions which preclude the interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-7h7f93	Evaluation of electromyographic activity and cutaneous temperature of the rectus abdominis muscle on exercises on the vibrating platform	Data analysis completed	Intervention	2020-09-24	<NULL>	<NULL>	4291	Evaluation of electromyography and thermography of the rectus abdominis muscle on exercises on the vibrating platform	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7h7f93	<NULL>	Healthy volunteers; both genders; age between 18 and 30 years; Normal BMI; sedentary; able to perform training on a vibrating platform.	Be performing aesthetic treatment in the abdominal region; practice physical activity regularly; presenting musculoskeletal injuries; have cardiovascular problems; pregnancy; acute low back pain; epilepsy; labyrinthitis; having had abdominal surgery recently; presenting umbilical hernia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-993xf7	Effect of educational booklet on sleep quality of the elderly	Data analysis completed	Intervention	2020-09-25	<NULL>	<NULL>	4292	Effect of printed Educational Technology on the sleep quality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-993xf7	<NULL>	Being 60 years old or older, living in the urban area, being assisted by the FHS, having good cognitive status, according to the Mini Mental State Examination, according to schooling criteria and sleep quality index greater than or equal to five points on the Pittsburgh Sleep Quality Index PSQI (which corresponds to poor sleep quality or presence of sleep disorder).	present auditory, visual or speech problems, which prevented the application of the instruments; plan to move to another city, have a surgical procedure scheduled, have a medical diagnosis regarding some type of mental illness and anxiety disorder (to obtain information about this criterion, there was questioning the CHWs and triangulation of data, by checking the medical records of the elderly, in the health unit); identification of risk for depression (obtained from the application of the geriatric depression scale); use antidepressant, sedative and psychotropic medications in general, in addition to chronic use of alcohol, cocaine, crack and amphetamines, for directly interfering in the outcome variable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-4vxy85	Periurethral Cleansing in Indwelling Urinary Catheterization: randomized controlled trial.	Recruitment completed	Intervention	2020-09-25	<NULL>	<NULL>	4293	Periurethral Cleansing in Indwelling Urinary Catheterization: randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4vxy85	<NULL>	Have 18 years or more and have indication of use of indwelling urinary catheterization.	Positive urine culture at the first sample, patients using antibiotics, patients with chronical kidney failure, patients with neurogenic bladder and patients which the second urine sample could not be collected.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-6nrnk9	Two techniques for osseous preservation after tooth extracton: a clinical study	Not yet recruiting	Intervention	2020-09-25	<NULL>	<NULL>	4294	Assessment of two different techniques for alveolar preservation and patient reports	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-31	Universidade Federal do Rio Grande do Sul	Universidad Científica del Sur	https://ensaiosclinicos.gov.br/rg/RBR-6nrnk9	<NULL>	Individuals with 18 years-old or older and periodontally healthy; less than 10 percent bleeding on probing without obvious periodontal pockets; present a non-molar tooth with extraction indicated; Type II or I sockets; Present a cone beam computed tomography (up to 1 month) of the region; No history of systemic diseases that contraindicate the surgical procedure, including the need for antibiotic prophylaxis; Do not use continuous use drugs including anti-inflammatory steroids and non-steroids; Present at least two tooth adjacent to the element that will be extracted; Not be pregnant or breastfeeding.	Not able to attend postoperative evaluations; Presenting symptoms of infection or hypersensitivity in the operated area; Smokers or ex-smokers (less than one year); Patients with fractures of the vestibular bone at the time of extraction with more than 50% loss of vestibular wal; Extractions with complications/accidents lasting more than 45 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-4tbgv6	DASH diet (Dietary Approaches to Stop Hypertension) for pregnant women with diabetes and the effects of diet on the health of mother and son	Recruiting	Intervention	2016-05-27	<NULL>	<NULL>	4295	"DASH diet (Dietary Approaches to Stop Hypertension) Effect on Perinatal Outcome
Pregnant Women with Diabetes Mellitus"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Universidade Federal do Rio de Janeiro - UFRJ	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4tbgv6	<NULL>	Pregnant adults, diagnosis of diabetes mellitus ( types 1 and 2 ) of singleton pregnancy; non-smokers and non-users of alcohol; gestational age up to 28 weeks.	Pregnant women with chronic comorbidities such as kidney or liver disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-5snp6g	The effect of the Application of Potassium Nitrate with the addition of Ozone on the Reduction of Sensitivity after Dental Whitening in the Office.	Not yet recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4296	Evaluation of the Application of 5% Ozonized Potassium Nitrate in the Reduction of Sensitivity after Office Bleaching - Clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5snp6g	<NULL>	The study will include: patients of both sexes, aged between 18 and 35 years; with the presence of all vital anterior teeth, never bleached or restored; with periodontal health; no history of spontaneous dental pain; who do not use toothpaste with desensitizing properties and are willing to return to future evaluations during the research period.	The study will exclude: patients with missing anterior teeth, affected by caries lesions, with the presence of recession, with some type of restorative or prosthetic treatment or who use a fixed orthodontic appliance; with bruxism or visible enamel cracks; with a history of periodontal disease or active periodontal disease; with a history of dental hypersensitivity; with color change in the teeth due to fluorosis or tetracycline; who make use of many medications and pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-9jwgkv	Effect and safety of Microneedling in the treatment of Frontal Fibrosing Alopecia	Recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4297	Efficacy and safety of Percutaneous Collagen Induction by Needles in the treatment of Frontal Fibrosing Alopecia	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Hospital Universitário Walter Cantídeo Universidade Federal do Ceará	Hospital Universitário Walter Cantídeo Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9jwgkv	<NULL>	Patients with clinical diagnosis of Frontal fibrosing alopecia will be selected, including those with increased frontotemporal recess, associated or not with follicular papules and rarefaction of eyebrows; or histopathological diagnosis compatible with frontal fibrosing alopecia with follow up appointments at the Dermatology Department of  Walter Cantideo University Hospital.  Patients must be aged between 18 and 70 years old and must sign who the Informed Consent Form (ICF), with availability to attend periodic appointment evaluations.	Patients with the following conditions will be excluded: Pregnancy; Vitiligo, psoriasis or other skin diseases that present Koebner&apos;s phenomenon (development of chronic dermatosis in trauma areas); Active infections in the areas to be treated with microneedling; Presence of keloids in previous scars; History of allergy to topical or injectable anesthetic; Patients with psychiatric disorders or other clinical diseases that contraindicate the procedure; Patients who refuse to sign the Informed Consent Form (ICF) or who are unable to attend to periodic appointment evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-5pdp82	Clinical study of different dental ceramics for partial restorations	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4298	Milled Feldspathic and Lithium Disilicate Onlays with a 2-Year Follow-Up: Split-Mouth Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-02	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	Universidade Estadual Paulista - Instituto de Ciência e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-5pdp82	<NULL>	Presence of caries injury; defective amalgam or composite resin restorations in the posterior dentition; suitable for restoration with ceramic onlays; presence of antagonistic tooth; over 18 years; good general and oral health; absence of orthodontic appliances; absence of malocclusion and dental malformation; absence of non-carious cervical lesions; vital posterior teeth and proven periodontal health.	Absence of caries lesion; suitable old restorations; little coronary destruction; absence of antagonistic tooth; less than 18 years; uncontrolled systemic impairment; orthodontic appliance users; presence of malocclusion and dental malformation; presence of non-carious cervical lesions; posterior teeth treated endodontically and periodontal health compromised.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-3v4cj9	Educational technologies to promote the mother&apos;s confidence in breastfeeding: Clinical Trial with flipchart and Motivational Interview	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4299	Effects of intervention with educational technologies to promote maternal effectiveness when breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-22	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3v4cj9	<NULL>	Immediate puerperium; minimum 6 hours postpartum; 14 years of age or older; single term pregnancy; with newborn in rooming-in; newborn with capacity for effective suction and thermal control; have a telephone contact.	Adolescent without permission from parents or guardians; maternal or neonatal contraindication for breastfeeding; supposed cognitive limitation; hearing impaired.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-8j8wyz	Phase III of the research, unicentric, national, prospective, double-blinded, randomized study, intended to evaluate the superiority of the kenkobio device efficiency compared to the placebo device, as well as evaluate the safety on various treatment groups, on research participants diagnosed with low back pain or with mild or moderate cervical pain, as well as demonstrating improved blood circulation	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4300	Phase III of the research, unicentric, national, prospective, double-blinded, randomized study, intended to evaluate the superiority of the kenkobio device efficiency compared to the placebo device, as well as evaluate the safety on various treatment groups, on research participants diagnosed with low back pain or with mild or moderate cervical pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	kenko patto photon industria e comercio ltda	Allergisa Pesquisa Dermato-Cosmética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8j8wyz	<NULL>	The research participants included on this research must satisfied the inclusion criteria: present capability of provide in written, in person, signed and dated the free and enlightened consent to participate on the research, in accordance with the Document of the Americas and to follow the guidelines and regulations applicable to the study procedures; present the ability to read, understand and complete the questionnaires applied to the study; be mentally empowered to provide your consent and meet all the study requirements; men and women aged between 18 and 65 years; presence of pain of mild to moderate intensity related to pain, in at least one type of pain according to a visual analog scale (VAS) of and considering the following intensity criterion: score 1 to 3 = mild pain; score 4 to 6 = moderate pain.	The research participants, that will be included on this research, may not have the following exclusion criteria: research participants which participated previously on any clinical research involving products under investigation within 30 days before randomization; history of non-adherence to previous studies; people who are directly involved in the study; use of opioids 07 days before the randomization visit; use of intra-articular steroids or hyaluronic acid injection or other immunosuppressive medication 3 (three) months before the randomization visit; current pregnancy or lactation during 3 months before the study begins; imminent need for primary surgical treatment; known history of gastrointestinal diseases, urological or current pelvic inflammatory disease, that may cause symptoms of pelvic pain, such as endometriosis; cervical and lumbar pain caused by neurological symptoms; history or suspicion of cancer, such as: Primary tumors (vertebra or spine), Metastatic vertebral tumors (mostly on  breast, lungs or prostate); significant systemic mental or chronic illness, that may interfere with the pain evaluation or the ability to complete the study; grade 3 obesity (BMI greater than or equal to 40 kg/m2); infectious diseases such as (eg, discitis, epidural abscess, osteomyelitis); patients with diseases such as herniated disc, osteoid osteoma; spondyloarthropathies, fibromyalgia, compression fracture, osteoarthritis, among other diseases of specific structural injuries; use of pacemaker, possibility of using defibrillator; undergoing hemodialysis sessions; use of magnetic mattresses and / or equipment that have the same or similar operating principle as the investigational product; presence of neoplastic disease with indication for systemic chemotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-9v7gj4	The impact of adapted functional training and pilates on the symptoms of individuals with parkinson&apos;s disease	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4301	The impact of adapted functional training and the solo pilates method on motor and non-motor symptoms of individuals with parkinson&apos;s disease	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2021-02-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9v7gj4	<NULL>	Inclusion criteria are defined as, participants with a clinical diagnosis of PD following the UK brain bank criteria (HUGHES et al., 1992); both sexes; aged 50 years or over; with stable doses at; at least two weeks; no change in medication; without any functional training for at least three months.	Exclusion criteria were, participants who did not reach the MMSE cut-off point (considering educational level) (BERTOLUCCI et al., 1994); classified in stage 5 PD (HOEHN; YAHR, 1967); who performed practice of any physical exercises to avoid confusion bias in the intervention; who did not complete all stages of the study; were not present in 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-2h2hjy	Physical intervention program in patients with schizophrenia	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4302	"Inflammation and Muscle Injury in Schizophrenia: through physiological and
biochemicals"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-22	Universidade Federal do Rio Grande do Sul	Hospital de clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2h2hjy	<NULL>	"Inclusion criteria for patients
Diagnosis of schizophrenia according to DSM-5; Age between 18 and 65 years; Be under drug treatment; Not be involved in another physical activity program.

Inclusion criteria for controls
For the pairing of the controls, they were recruited by the same sex of the case, by age, 3 years upwards or downwards of the case, the same social class, and not to present a serious mental illness (dementia, depression, mania, generalized anxiety disorder or disorder obsessive-compulsive)."	"Exclusion criteria for patients
Use alcohol or drugs in the last month; Systemic or neurological disease; Motor disability; Presence of suicide risk at the time of the intervention; Be pregnant; Don&apos;t accept to participate in the study.

Exclusion criteria for controls
They followed the same criteria as the cases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-7hxwxy	The Effect of Meditation on Stress and Anxiety Level in Women with Breast Cancer	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4303	the effect of meditation on the level of distress and anxiety in women with breast cancer: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-10	Universidade Federal do Piauí -UFPI	Universidade Federal do Piauí -UFPI	https://ensaiosclinicos.gov.br/rg/RBR-7hxwxy	<NULL>	Recent diagnosis of breast cancer, starting chemotherapy, ECOG 0 to 1 or Karnofsky Index greater than 70, stage I to IV, age 20 to 65 years, availability to participate in interventions	Women on hormone therapy, severe mental disability, use of controlled medications, abuse of illicit substances, cognitive impairment and previous experience of meditation or yoga	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-4qgpg5	Educational intervention for food consciouness in women	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4304	"Sensoriality as a marker of the relationship with food: education program
with sensory and cognitive exercises"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4qgpg5	<NULL>	The study population will consist of adult women (aged 20 to 59 years) with Body Mass Index between 18,5 and 34,9 kg/m², weight gain greater than 5% in the previous year and that refer desire to improve their relationship with food.	It will not be included pregnant or lactating women, smokers, diabetics, women using psychiatric drugs, nutritionists and women with a BMI of 35 kg/m² or greater (grade 2 obesity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-5wq5s9	Impact of tonsil and adenoid removal surgery and maxillary expansion on respiratory capacity in children with Obstructive Sleep Apnea Syndrome (OSA) - randomized clinical study	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4305	Impact of Rapid Maxillary Expansion in the treatment of children with Obstructive Sleep Apnea Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-09	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5wq5s9	<NULL>	The inclusion criteria included: (1) clinical symptoms of breathing disorder, such as snoring, and mouth breathing; (2) palatine tonsil hypertrophy classified by means of mouth examination according to the grading criteria of Brodsky; (3) adenoid hypertrophy assessed by means of flexible nasoendoscopy; (4) diagnosis of OSA with the aid of PSG examination revealing an obstructive AHI bigger then 1 event/hour, according to the criteria of the American Academy of Sleep Medicine (AASM);(5) constricted maxillary arch, high palate, unilateral or bilateral posterior crossbite, and/or some degree of mandibular retrusion; (6) children between 5 and 12 years old incomplete.	Exclusion criteria included: (1) obese children (BMI bigger then 95 kg/m2); (2) genetic syndrome; (3) craniofacial anomalies; (4) systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-7xzhkn	Effects of a physical exercise program and health advice on the sedentary behavior of adolescents	Data analysis completed	Intervention	2020-09-29	<NULL>	<NULL>	4306	Stand up: for a healthier life	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7xzhkn	<NULL>	Belong to the seventh, eighth or ninth grade of elementary school; belong to the first year of high school; healthy volunteers; both genders; age between 13 and 16 years.	Age under 13 years; age 17 years or older; physical or mental condition that made it impossible to participate in the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-9z82kj	Comparative evaluation of the Protection from the Protective Films through instrumental measures and images	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4307	Comparative evaluation of the Protection Potential of Protective Films through instrumental measures and images analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-07	3M do Brasil Ltda	3M do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-9z82kj	<NULL>	Healthy study subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day (s) and at the time (s) scheduled for the assessments; ability to give consent for participation in the study; aged from 18 to 75 years old; male / female / both genders; phototype (Fitzpatrick): I to III; signature of the informed consent form by the subject; subjects who respect the conditioning period not applying topical medications, creams or other skin cleansing products in the assessment sites 3 days before visit 02 (D1)	pregnancy or breastfeeding; skin pathology on the area of product application; type 1 diabetes mellitus: insulin-dependent diabetes, presence of complications resulting from diabetes (retinopathy, nephropathy, neuropathy), presence of dermatosis related to diabetes (lipoidic necrobiosis, plantar ulcer, ring granuloma, opportunistic infections); antecedents of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma; immunological insufficiency; use of systemic corticosteroids or immunosuppressant drugs; skin diseases: vitiligo, psoriasis, lupus, atopic dermatitis; any other condition that, in the investigator opinion, might directly interfere with the study or put the subject health under risk; smokers; subjects in menopause or who state being suffering from heat waves; excessive hairiness in the experimental site; current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs; history of reaction to the category of the tested product, creams, skin cleansers, cosmetics, personal care products and/or topical medicines; Participating in another study, having participated in another study in the two weeks prior to the start of the study or intending to participate in another study during the study period; history of sun hypersensitivity (skin defect or damage to sensitive or light-reactive skin);  tattoos, scars, spots or other blesmihes on the assessment areas that might interfere with the study assessments; skin marks on the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, sunburn, vascular malformations, scars, increased hairiness, freckles, warts, tattoos and scars); subjects who have applied any topical medications, creams, or other skin cleansers in the assessment sites during the washout period;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-66j5yf	Assessment of the potential for primary irritation and skin sensitization without the use of four etectrodes	Recruitment completed	Intervention	2020-09-29	<NULL>	<NULL>	4308	Assessment of the Skin Primary and Cumulative Irritation Potential and Skin Sensitization Potential of Four Electrodes (071075-01/04), Under Controlled and Maximized Conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-30	3M do Brasil Ltda	Allergisa Pesquisa Dermato-Cosmética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-66j5yf	<NULL>	healthy subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; ability of giving consent for participation in the study; aged from 18 to 70 years old; phototype (Fitzpatrick): I to IV; any gender.	"pregnancy or breastfeeding; any skin marks on the test site that might interfere with the assessment of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased pilosity, and great amounts of ephelides and nevus, sunburns); active dermatosis (local or disseminated) that might interfere with the results of the study; antecedents of allergic reactions, irritation or sensation of intense discomfort to topical products: cosmetics, health products or medications; atopy antecedents, (atopic dermatitis, allergic rhinitis, allergic bronchitis, allergic conjunctivitis, etc.); discomfort sensation with temperature changes (too hot/too cold) and/or when you are in the air conditioner; subjects with history of allergy to the materials used in the study; history of pathologies aggravated or triggered by ultraviolet radiation; subjects suffering from immunodeficiencies; intense exposure to sunlight or to sun tanning sessions up to 15 days before the initial assessment; intention of being intensely exposed to sunlight or to sun tanning sessions during the study period; forecast to sea bath, to go to the pool or bathtub during the study; subjects who practice water sports; dermographism;aesthetic and/or dermatological treatment performed on the body within 03 weeks before selection; use of the following topical or systemic medications: immunosuppressant drugs, antihistamines, non-hormonal antiinflammatory drugs, and corticosteroids up to 2 weeks before selection; in case of deposit corticosteroids, up to 1 month before selection; oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month before the study started; forecast  of vaccination during the study or up to 03 weeks before the study; be currently taking part or have already participated in another clinical study which was concluded less than 07 days before selection, if the previous study is an in-use study; be currently taking part or have already participated in another clinical study which was concluded less than 21 days if the previous study was a Compatibility study or an Adverse Reaction Investigation; any conditions not mentioned above which the investigator finds compromising to the evaluation of the study; history of lack of adherence or unwillingness to adhere to the study protocol;
professionals who are directly involved in the performance of the current protocol as well as their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-9n7kfw	"The effect of Lactobacillus acidophilus e
Bifidobacterium lactis on hepatic steatosis and difficulty in insulin action in obese adolescents: A randomized clinical trial"	Recruitment completed	Intervention	2020-09-30	<NULL>	<NULL>	4309	"Efficacy of Lactobacillus acidophilus e
Bifidobacterium lactis on Nonalcoholic Fatty Liver Disease and insulin resistance in obese adolescents: A randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-17	Escola Bahiana de Medicina e Saúde Pública	Delphin Medicina DIagnóstica	https://ensaiosclinicos.gov.br/rg/RBR-9n7kfw	<NULL>	Adolescents between 10 to 19 years old; Diagnosis of obesity, based on the BMI/age indicator above +2 z scores of the WHO reference curve; Previous ultrasound diagnosis of Non-Alcoholic Fatty Liver Disease; Signature of the Review Board Authorization Form; Previous history of attendance to the service (absence of absences in the previous year); Absence of diabetes mellitus (fasting blood glucose below 100 mg/dl); Living in Salvador or metropolitan urban area;	Presence of endogenous obesity; Presence of psychiatric comorbidity or disease that interferes with weight evolution; Use of medications such as metformin, statins, laxatives, antibiotics, antidepressants, corticosteroids, anxiolytics and / or any other medication that may interfere with the gut microbiota; Be classified as SGA (Small for Gestational Age) at birth;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-6cmf4j	Effects of two exercise protocols on pain, functional mobility and quality of life in individuals with hip osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4310	Effects of combined versus aerobic exercise on pain, functional mobility and quality of life in individuals with hip osteoarthritis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cmf4j	<NULL>	"individuals aged at least 30 years; both sexes; with clinical diagnosis of osteoarthritis of
hip uni or bilateral; sedentary in the last 6 months"	"individuals with hip and / or knee arthroplasty, whether total or partial;
rheumatoid arthritis, neurological, cardiovascular and / or pulmonary diseases that can compromise
execution of the exercise protocol. Discontinuation criteria: discontinuation of
individuals who did not attend two or more sessions and / or those who gave up
participate in the study during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-93rx9q	Blood flow occlusion in patients with knee osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4311	Blood flow restriction with different load levels in patients with knee osteoarthritis: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-93rx9q	<NULL>	Individuals of both sexes will be included; 50 years old and over; diagnosed with bilateral or unilateral knee osteoarthritis (OA) according to American College of Rheumatology criteria; moderate tosevere (scores between 5 and 13 on the Lequesne Questionnaire); with a minimum score of 24 points in the Mini Mental State Examination and who sign the Informed Consent Form (ICF)	Individuals with a history of surgery or any invasive procedure of the affected knee(s) will be excluded; who have undergone a physical therapy or strengthening program for knee injuries in the past three months; planned events, such as knee replacement or travel, which may interfere with individuals&apos; participation during the study period; history of acute myocardial infarction and / or stroke; history of peripheral arterial disease and / or deep vein thrombosis; history of cancer that has generated limitations or restrictions to physical exercise; decompensated systemic blood pressure without medical supervision and changes in dose or type of anti-inflammatory or analgesic drugs in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-85vqk6	Strength and flexibility training for pain reduction and work performance improvement	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	4312	Effects of an exercise protocol for work related musculoskeletal disorders in grape collectors  from the São Francisco Valley	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-85vqk6	<NULL>	Subjects of both sexes aged 18 to 50 years; physically independent; has not participated in structured exercise programs for at least 3 months; absence of clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise during pre-participation screening; chronic shoulder pain with score higher or equal trhee points in the numeric pain scale (0-10); have a positive result in at least three shoulder pain-specific orthopedic tests, namely: Neer, Hawkins-Kennedy, Jobe, painful arch and external rotation resistance test; no history of shoulder trauma or surgery; not present musculoskeletal disorders that make it impossible to perform exercises; not having high blood pressure, cardiovascular disease, heart failure, myocardial infarction, cerebrovascular accident and / or diabetes; not being in gestational period; and being workers who perform activities with their hands over heads.	Performing any type of exercise for the upper limbs during the intervention period or engaging in another physical activity program; continuous use of drugs and / or ergogenic resources that positively or negatively interfere with performance; participants affected by limiting health conditions; and pregnancy during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-43pk59	To Evaluate the Brain and Movement of people with Down syndrome after Noninvasive Electrical Stimulation associated with Virtual Reality games	Recruiting	Intervention	2019-10-31	<NULL>	<NULL>	4313	Brain Activity and Upper Limb Movement Analysis in individuals with Down Syndrome undergoing Transcranial Direct Current Stimulation associated with Virtual Reality	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Centro universitário Evangélico	https://ensaiosclinicos.gov.br/rg/RBR-43pk59	<NULL>	"Phase 1:
Individuals with no diagnosis of cognitive and / or neuromotor disorders; 6 to 12 years old; appropriate cooperation for the performance of the procedures; consent to participate in the research by signing the consent form.

Phase 1, 2 and 3:
diagnosis of DS; ability to understand and collaborate to perform the procedures involved in the study; ; cognitive age between 6 and 12 years defined by the WASI (abbreviated Wechsler Intelligence Scale) scale; consent to participate in the research by signing the consent form."	All stages: children who have undergone surgical procedures in the last 12 months prior to the start of training sessions; children who have structured orthopedic deformities in the upper limbs or spine with surgical indications; carriers of uncontrolled epilepsy; presence of metal implants in the brain; hearing aids; associated neurological pathology; make use of a cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-73g83h	The use of beetroot, watermelon and ginger juice during assisted reproduction treatment	Recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4314	Supplementation with beetroot, watermelon and ginger juice in assisted reproduction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-03	Fertility - Centro de Fertilização Assistida	Fertility - Centro de Fertilização Assistida	https://ensaiosclinicos.gov.br/rg/RBR-73g83h	<NULL>	Healthy women between 18 and 40 years of age, without previous intracytoplasmic sperm injection treatment.	Vitrified, thawed or donated oocytes, surgical sperm retrieval, vitrified, thawed embryo transfer, or pre-implantation genetic testing. Patients with metabolic diseases, endometriosis, neoplasia, or any other patology that preclude the use of gonadotropin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-4ypn69	PA GEL 0415: Open, randomized clinical trial of efficacy and safety of sequential use of a single dose of antimoniate intralesional meglumine and topical paromomycin gel compared to three intralesional applications of meglumine antimoniate in the treatment of cutaneous leishmaniasis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4315	"Open, randomized clinical trial of efficacy and safety of sequential use of
single dose of intralesional meglumine antimoniate and topical paromomycin gel
compared to three intralesional applications of meglumine antimoniate in the
treatment of cutaneous leishmaniasis"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-02-01	Banco Nacional de Desenvolvimento Nacional	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4ypn69	<NULL>	"Age group bigger then 12 years.
Both sexes.
Presence of skin lesions exclusively of ulcerated type with parasitological confirmation by at least one of the positive tests: anatomo-pathological, imprint, culture, PCR.
Presence of a maximum of three lesions up to 3 cm in their largest diameter, in any location, except the face and ear.
Agreement to participate voluntarily and signing the informed consent form. In the case of participants aged between 12 and 17 years, in addition to the parent&apos;s or legal guardian&apos;s consent, the minor&apos;s consent form will also be required."	"Presence of mucosal involvement or presence of non-ulcerated lesion (papule, nodule, plaque, vegetative).
Pregnancy or lactation.
Systemic or topical use (in the lesion) of corticosteroids that cannot be suspended during the follow-up period in the study (between D1 and D180).
Use of any treatment indicated for leishmaniasis within 90 days prior to inclusion in this study.
5. HIV infection or other immunodebilitating disease, defined as follows
The. History of bone marrow transplantation less than 24 months ago or transplantation of solid organs at any interval, if using immunosuppressive therapy.
B.Carriers of autoimmune disease in specific treatment or in activity (eg lupus, rheumatoid arthritis).
c. Use of immunosuppressive or immunobiological drugs (with the exception of vaccines) in the 60 days prior to screening prior to screening. Drugs used in the treatment of autoimmune diseases (such as monoclonal antibodies, TNF alpha inhibitors, intracellular signaling blockers) are considered.
d. Patients who received antineoplastic therapy in the 3 months prior to screening.
and. Primary immunodeficiency patients.
QTc interval on electrocardiogram greater than 450 ms for men and 460 ms for women31.
Users of intravenous drugs or other chemical dependencies (including alcohol abuse.
History of hypersensitivity to any study drug.
Any condition that prevents follow-up with the frequency recommended by the study.
10. Secondary wound infection (in this case, wait for resolution with usual clinical treatment recommended in the service to reassess inclusion).
If any previous topical medication is used, the patient must stop the application and may be included when there is no residue present."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-5w9tx9	Effect of a board game on the knowledge of the elderly about HIV / AIDS prevention	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4316	Effectiveness of a board game on the knowledge of elderly people in a school context about HIV /Aids prevention	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-04-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5w9tx9	<NULL>	Be sixty years old or over; be regularly enrolled in schools that have the EJA modality in Health District IV and have at least six months of study at EJA.	Elderly people who are enrolled but are not attending classes during the data collection period provided for by this study; elderly people who have had cognitive impairment assessed using the 6-item cognitive decline test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-3wz9b2	Safety and efficacy of a Injectable Triamcinolone Acetonide commercial preparation for the treatment of facial fat deposits	Recruitment completed	Intervention	2019-08-29	<NULL>	<NULL>	4317	Randomized, blind, controlled study to assess safety and efficacy of a Injectable Triamcinolone Acetonide commercial preparation for the treatment of facial fat deposits	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-25	Centro Brasileiro de Estudos em Dermatologia	Centro Brasileiro de Estudos em Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-3wz9b2	<NULL>	Signed ICF; Subjects aged 18 years or older with clinical indication for study treatments; Medical history and physical examination that, in the opinion of the investigator, does not interfere with the progress of the study; Women of childbearing potential should have a negative urinary pregnancy test at visit 1. These subjects should use a highly effective contraception method during the study (combined oral contraceptives [estrogen and progesterone] or implanted contraceptives (with a stable dose for at least 1 month prior to study entry), bilateral tubal ligation, hormonal intrauterine device (inserted at least 1 month prior to study entry), strict abstinence (at least 1 month prior to entry into the study and agree to continue for the duration of the study), or vasectomized partner (at least 3 months prior to study entry) or use of condom; Women presenting for childbearing potential (eg, before menstruation, post menopause (absence of menstrual bleeding for 1 year before entry into the study), hysterectomy, or bilateral ovariectomy, less than one year postmenopausal); Accumulation of fat in the submental area and perimandibular area posterior to the melomental sulcus; Body Mass Index (BMI = weight/height2) from 18.5 to 29.9 kg/m2; Availability to maintain stable weight throughout the study period (maximum variation of 5% of total body weight throughout the study); Understand and sign the Informed Consent Term (ICF) before any study procedure is performed; Availability and ability to comply with protocol requirements and study duration.	"Pregnant and/or breastfeeding women, or women who wish to become pregnant during the study period; Participation in another clinical study less than 30 days before the start of the present study; Presence of scars or other marks on the face that may interfere with the evaluation of results; Treatments and/or procedures based on lasers, lights and waves to improve the facial contour less than 6 months before the beginning of the study; History (less than 36 months) or planning treatment with poly-L-lactic acid on the face; History (less than 12 months) or plan treatment with hyaluronic acid or other non-permanent fillers on the face; History or planning treatment with permanent fillers on the face; Any previous surgical intervention or during the study to improve facial contour; Contraindications to perform MRI, as specified by the radiology service where the examination will be performed, such as claustrophobia, presence of metallic implants, recent tattoos; Smoking;
Neoplastic diseases, osteoporosis, diabetes mellitus, cutis laxa and / or collagen diseases, Cushing&apos;s syndrome, glaucoma; Under use or having used the following treatments within the time period specified prior to visit 1:
Anticholinesterases, cholestyramine, ketoconazole (7 days)
Aminoglutethimide, amphotericin B, potassium-depleting diuretics, oral anticoagulants, antidiabetics, tuberculostatic drugs, cyclosporine, digitalis glycosides, barbiturates, phenytoin, carbamazepine (30 days); Untreated cardiovascular or endocrine diseases; Coagulation disorders; Inflammations or infections in the study area; History of sensitivity to components of the formula; 
Intense cutaneous flaccidity, which in the opinion of the investigator, may interfere with the results of the study; Any disease or condition that, in the opinion of the investigator, may interfere with the assessments or participation in the study; Subjects with history of non-adherence to medications or showing difficulties to adhere to the study protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-2h29zc	Development and evaluation of a cell phone game on healthy eating for adolescents in the city of Diamantina, Minas Gerais	Recruiting	Intervention	2020-10-02	<NULL>	<NULL>	4318	Development and evaluation of the use of a mobile phone / tablet application as a communication strategy of the Food Guide for the Brazilian Population for adolescents in the municipality of Diamantina, Minas Gerais	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-15	Laboratório de biologia do exercício e imunometabolismo	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2h29zc	<NULL>	Adolescents aged 14 to 16 who have a smartphone that can receive the application.	Adolescents who do not have a smartphone that can receive the application.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-5v3k5d	Study of the use of ozone therapy adjunct to the treatment of Covid-19 infections	Recruiting	Intervention	2020-10-02	<NULL>	<NULL>	4319	Clinical, Open label, Phase III, Multicenter, Prospective, Comparative, Controlled, Randomized Study to Assess the Effectiveness of Systemic Oxygen Therapy with Medicinal Ozone in Early Control of Disease Progression in Patients with COVID-19 who have Acute Infectious Respiratory Symptoms	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-07-05	Sociedade Brasileira de ozonioterapia médica	Sociedade Brasileira de ozonioterapia médica	https://ensaiosclinicos.gov.br/rg/RBR-5v3k5d	<NULL>	The inclusion criteria for this study are; Patients with acute infectious respiratory symptoms evaluated in hospital or outpatient settings, based on the flow chart suggested by Hospital Israelita Albert Einstein (19.03.2020); Laboratory diagnosis confirmed for Covid-19 (RT-PCR of nasal and / or oropharyngeal secretion) ; Both sexes; Age greater than or equal to 18 years; Signed free and informed consent form; Availability to follow the research protocol	G6PD enzyme deficiency (activity below 60% according to Yoshida classification 242; Pregnancy; Women in lactation Clinically decompensated hyperthyroidism; Severe decompensated arterial hypertension; Severe active or recent bleeding from severe Anemia (Hemoglobin less than 6 g / dL); severe unstable cardiovascular disease ; Participation in another clinical study for less than 30 days; Impossibility of adhering to the research protocol; Any important clinical condition that, in the Investigator&apos;s opinion, may bring risks to the patient and prevent him from proceeding safely; Suspected or recent pregnancy as a precaution due to ethical issues, since there are studies of genotoxicity in experimental animals proving the safety of Ozone Therapy in the sense of the absence of genetic changes induced by Medicinal Ozone; any important clinical condition that in the Researcher&apos;s opinion may bring risks to the patient and prevent that the research protocol proceeds with safety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-8h7q82	The effect of chloroquine, hydroxychloroquine OR ivermectin in patients with severe manifestations of coronavirus	Recruitment completed	Intervention	2020-10-02	<NULL>	<NULL>	4320	"Phase II study on chloroquine and hydroxychloroquine in patients with manifestations
serious cases of COVID-19 infection"	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Federal de Roraima	Universidade Federal de Roraima	https://ensaiosclinicos.gov.br/rg/RBR-8h7q82	<NULL>	laboratory test confirming infection by SARS-CoV-2 (positive serologic test IgM or rt-PCR); hospitalized with a clinical, epidemiological and radiological picture compatible with COVID-19; over 18 years old; present a severe form of the disease characterized by one of the following clinical signs: dyspnea, tachypnea (more than 30 irpm), peripheral oxygen saturation less than 93% (pulse oximeter evaluation), PaO2 / FiO2 ratio less than 300, or infiltrate pulmonary more than 50% of the parenchyma seen on chest tomography or chest radiography	under 18 years old; indigenous people; patients not fluent in Portuguese;